Watanabe Kazuhide 渡邉和秀

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WATANABE KAZUHIDE 渡邉和秀

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Researcher Number	40749397
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員主管研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員主管研究員 2018 – 2021: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 2016: 国立研究開発法人理化学研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43010:Molecular biology-related Except Principal Investigator Basic Section 61010:Perceptual information processing-related
Keywords	Principal Investigator 上皮間葉移行 / 細胞多様性 / 間葉上皮移行 / OVOL2 / 転写因子 / ZEB1 / プロテアソーム分解 / 腫瘍組織内多様性 / 転移性乳癌 / ユビキチンプロテアソーム … More / 転移性乳がん / 組織多様性 / 乳腺上皮細胞 / Perturb-seq / 乳腺 / 上皮幹細胞 / バイオテクノロジー / 再生医学 / in vivo reprogramming / 間葉上皮転換 / 上皮間葉転換 / エピゲノム / 表皮細胞 / 生体内リプログラミング / systems biology / RNA-seq / Systems biology / Epigenomics / Transcriptomics / MET / 遺伝子発現 / クロマチン / epithelial cell / transcription factor / chromatin states / ATAC-seq / CAGE / TGFbeta / EMT … More Except Principal Investigator 画像情報学 / バイオ医療画像解 / バイオイメージインフォマティクス / バイオ医療画像解析 / 教師なし学習 / 半教師あり学習 / 弱教師学習 / 機械学習 Less

転写因子ZEB1のプロテアソーム制御によるEMT多様性創出の分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  渡邉和秀
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Institute of Physical and Chemical Research
Weakly supervised learning using domain knowledge and meta-data in life science
- Principal Investigator
  
  Bise Ryoma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 61010:Perceptual information processing-related
- Research Institution
  Kyushu University
Systematic analysis for cellular diversity formation in epithelial tissues by regulators of EMT/METPrincipal Investigator
- Principal Investigator
  
  渡邉和秀
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Institute of Physical and Chemical Research
Establishing a rapid and highly efficient method for in vivo direct reprogramming of fibroblasts into epithelial lineages using mesenchymal-to-epithelial transition program(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  Watanabe Kazuhide
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
Analyzing transcription factor network and chromatin regulation during epithelial-to-mesenchymal transitionPrincipal Investigator
- Principal Investigator
  
  WATANABE KAZUHIDE
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2019 2017 2016 2015

All Journal Article Presentation

[Journal Article] Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb12022
- Author(s)
  Han Yingying、Villarreal-Ponce Alvaro、Gutierrez Guadalupe、Nguyen Quy、Sun Peng、Wu Ting、Sui Benjamin、Berx Geert、Brabletz Thomas、Kessenbrock Kai、Zeng Yi Arial、Watanabe Kazuhide、Dai Xing
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 2 Pages: 110240-110240
- DOI
  10.1016/j.celrep.2021.110240
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0165
[Journal Article] Comparative single-cell transcriptomes of dose and time dependent epithelial?mesenchymal spectrums2022
- Author(s)
  Panchy Nicholas、Watanabe Kazuhide、Takahashi Masataka、Willems Andrew、Hong Tian
- Journal Title
  
  NAR Genomics and Bioinformatics
  
  Volume: 4 Issue: 3
- DOI
  10.1093/nargab/lqac072
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KK0165
[Journal Article] Effective Pseudo-Labeling based on Heatmap for Unsupervised Domain Adaptation in Cell Detection2022
- Author(s)
  H. Cho, K. Nishimura, K. Watanabe, and R. Bise
- Journal Title
  
  Medical Image Analysis
  
  Volume: 79 Pages: 102436-102449
- DOI
  10.1016/j.media.2022.102436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04211, KAKENHI-PROJECT-21K19829, KAKENHI-PROJECT-22KJ2396, KAKENHI-PROJECT-16KK0165
[Journal Article] Weakly supervised cell instance segmentation under various conditions2021
- Author(s)
  Nishimura Kazuya、Wang Chenyang、Watanabe Kazuhide、Fei Elmer Ker Dai、Bise Ryoma
- Journal Title
  
  Medical Image Analysis
  
  Volume: 73 Pages: 102182-102182
- DOI
  10.1016/j.media.2021.102182
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04211, KAKENHI-PROJECT-22KJ2396
[Journal Article] Cell Detection in Domain Shift Problem Using Pseudo-Cell-Position Heatmap2021
- Author(s)
  Cho Hyeonwoo、Nishimura Kazuya、Watanabe Kazuhide、Bise Ryoma
- Journal Title
  
  International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI2021)
  
  Volume: 1 Pages: 384-394
- DOI
  10.1007/978-3-030-87237-3_37
- ISBN
  9783030872366, 9783030872373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04211, KAKENHI-PROJECT-21K19829, KAKENHI-PROJECT-22KJ2396
[Journal Article] Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity2019
- Author(s)
  Pervolarakis Nicholas、Nguyen Quy H.、Gutierrez Guadalupe、Sun Peng、Jhutty Darisha、Zheng Grace XY、Nemec Corey M、Dai Xing、Watanabe Kazuhide、Kessenbrock Kai
- Journal Title
  
  BioRxiv
  
  Volume: np
- DOI
  10.1101/740746
- Open Access
- Data Source
  KAKENHI-PUBLICLY-18H05106
[Journal Article] Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition2019
- Author(s)
  Watanabe Kazuhide、Panchy Nicholas、Noguchi Shuhei、Suzuki Harukazu、Hong Tian
- Journal Title
  
  BioRxiv
  
  Volume: NA
- DOI
  10.1101/627372
- Data Source
  KAKENHI-PUBLICLY-18H05106
[Journal Article] OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages2019
- Author(s)
  Watanabe Kazuhide、Liu Ye、Noguchi Shuhei、Murray Madeleine、Chang Jen-Chien、Kishima Mami、Nishimura Hajime、Hashimoto Kosuke、Minoda Aki、Suzuki Harukazu
- Journal Title
  
  BioRxiv
  
  Volume: NA
- DOI
  10.1101/577692
- Data Source
  KAKENHI-PUBLICLY-18H05106
[Journal Article] Overexpression of Transcription Factor Ovol2 in Epidermal Progenitor Cells Results in Skin Blistering2017
- Author(s)
  Lee Briana、Watanabe Kazuhide、Haensel Daniel、Sui Jennifer Y.、Dai Xing
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 137 Issue: 8 Pages: 1805-1808
- DOI
  10.1016/j.jid.2017.02.985
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06952
[Journal Article] An Ovol2-Zeb1 mutual inhibitory circuit governs bidirectional an multi-step transition between epithelial and mesenchymal states2015
- Author(s)
  1.Hong T.*, Watanabe K.*, Ha Ta C., Villarreal-Ponce A., Nie Q., and Dai X
- Journal Title
  
  PLoS Computational Biology
  
  Volume: 11 Issue: 11 Pages: e1004569-e1004569
- DOI
  10.1371/journal.pcbi.1004569
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06952
[Presentation] 転写因子ZEB1の制御によるEMTの空間多様性創出のメカニズム2023
- Author(s)
  坂本優太、高橋昌剛、渡邉和秀、鈴木治和
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K06025
[Presentation] Domain Extension in Cell Detection by Pseudo-Cell-Position Heatmap2021
- Author(s)
  Hyeonwoo Cho, Kazuya Nishimura (Kyushu Univ.), Kazuhide Watanabe (RIKKEN IMS), Ryoma Bise (Kyushu Univ.)
- Organizer
  画像の認識・理解シンポジウム(MIRU2021, オンライン開催)
- Data Source
  KAKENHI-PROJECT-20H04211
[Presentation] OVOL2 and tissue-specific reprogramming factors cooperatively induce epithelial phenotype in fibroblasts2019
- Author(s)
  Kazuhide Watanabe
- Organizer
  Keystone Symposia
- Data Source
  KAKENHI-PUBLICLY-18H05106
[Presentation] Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity2019
- Author(s)
  Kazuhide Watanabe
- Organizer
  Gordon Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05106
[Presentation] Differential regulation between velocity and directionality of cellular movement during epithelial-to-mesenchymal transition2017
- Author(s)
  渡邉和秀
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06952
[Presentation] Identification of ZEB1-dependent and -independent modes of chromatin accessibility regulation by TGF-beta in mammary epithelial cells2017
- Author(s)
  Kazuhide Watanabe
- Organizer
  Keystone symposia
- Data Source
  KAKENHI-PROJECT-15K06952
[Presentation] Differential regulation of epithelial and mesenchymal phenotypes during EMT by master transcriptional regulators2016
- Author(s)
  Kazuhide Watanabe
- Organizer
  2016 ASCB annual meeting
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-15K06952
[Presentation] Differential regulation of epithelial and mesenchymal phenotypes during EMT by master transcriptional regulators2016
- Author(s)
  Kazuhide Watanabe
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06952

1. Bise Ryoma (00644270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 須田年生 (60118453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 末廣大貴 (20786967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉澤明彦 (80378645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Dai Xing

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Watanabe Kazuhide 渡邉 和秀

WATANABE KAZUHIDE 渡邉 和秀

Research Projects

Research Products

Co-Researchers

転写因子ZEB1のプロテアソーム制御によるEMT多様性創出の分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Weakly supervised learning using domain knowledge and meta-data in life science

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Systematic analysis for cellular diversity formation in epithelial tissues by regulators of EMT/METPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Establishing a rapid and highly efficient method for in vivo direct reprogramming of fibroblasts into epithelial lineages using mesenchymal-to-epithelial transition program(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyzing transcription factor network and chromatin regulation during epithelial-to-mesenchymal transitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative single-cell transcriptomes of dose and time dependent epithelial?mesenchymal spectrums2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effective Pseudo-Labeling based on Heatmap for Unsupervised Domain Adaptation in Cell Detection2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Weakly supervised cell instance segmentation under various conditions2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell Detection in Domain Shift Problem Using Pseudo-Cell-Position Heatmap2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances reprogramming to epithelial lineages2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of Transcription Factor Ovol2 in Epidermal Progenitor Cells Results in Skin Blistering2017

Author(s)

Journal Title

DOI

Data Source

Watanabe Kazuhide 渡邉和秀

WATANABE KAZUHIDE 渡邉和秀