Ishii Yoshitaka 石井佳誉

… Alternative Names

石井佳誉イシイヨシタカ

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Researcher Number	40799045
Other IDs
Affiliation (Current)	2025: 東京科学大学, 生命理工学院, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京工業大学, 生命理工学院, 教授 2017: 東京工業大学, 生命理工学院, 教授 2015: 東京工業大学, 生命理工学院, 教授
Review Section/Research Field	Principal Investigator Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields / Structural biochemistry Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 自動解析 / 超高分解能 / 固体ＮＭＲ / 高速MAS / 超高磁場 / 蛋白質 / 感度増加 / 高次元NMR / 微量測定 / amyloid … More / 超高速MAS / アミロイド / タンパク質 / 高分解能化 / 構造生物学 / 固体NMR … More Except Principal Investigator 治療法 / アルツハイマー病 / 異常凝集体 / 神経細胞死 / 神経変性疾患 Less

超高分解能固体NMRと自動解析による非結晶性生体高分子と先端材料構造解析の新機軸Principal Investigator
- Principal Investigator
  
  石井佳誉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 32:Physical chemistry, functional solid state chemistry, and related fields
- Research Institution
  Tokyo Institute of Technology
多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Development of next geranaration solid-state NMR methods and applications to amyloid-ligand interactionsPrincipal Investigator
- Principal Investigator
  
  Ishii Yoshitaka
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Decoherenece Optimized Tilted-Angle Cross Polarization : A Novel Concept for Sensitivity-enhanced Solid-state NMR using Ultra-fast Magic Angle Spinning.2021
- Author(s)
  Matsunaga, T. ; Matsuda, I. ; Yamazaki, T. ; Ishii, Y.,
- Journal Title
  
  J. Magn. Reson.
  
  Volume: 322 Pages: 106857-106857
- DOI
  10.1016/j.jmr.2020.106857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21772
[Journal Article] Efficient solvent suppression with adiabatic inversion for 1H-detected solid-state NMR2021
- Author(s)
  Matsunaga Tatsuya、Okabe Ryotaro、Ishii Yoshitaka
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 75 Issue: 10-12 Pages: 365-370
- DOI
  10.1007/s10858-021-00384-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21772
[Journal Article] Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils2021
- Author(s)
  Wickramasinghe Ayesha、Xiao Yiling、Kobayashi Naohiro、Wang Songlin、Scherpelz Kathryn P.、Yamazaki Toshio、Meredith Stephen C.、Ishii Yoshitaka
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 30 Pages: 11462-11472
- DOI
  10.1021/jacs.1c03346
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Journal Article] NMR-based site-resolved profiling of ホイ-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.2020
- Author(s)
  Yiling Xiao, Isamu Matsuda, Masafumi Inoue, Tomoya Sasahara, Minako Hoshi, Yoshitaka Ishii
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 295 Issue: 2 Pages: 458-467
- DOI
  10.1074/jbc.ra119.008522
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04055, KAKENHI-PROJECT-15K21772, KAKENHI-PROJECT-20H03457
[Journal Article] Progress in proton-detected solid-state NMR (SSNMR) : Super-fast 2D SSNMR collection for nano-mole-scale proteins2018
- Author(s)
  Yoshitaka Ishii*, Ayesha Wickramasinghe, Isamu Matsuda, Yuki Endo, Yuji Ishii, Yusuke Nishiyama, Takahiro Nemoto, Takayuki Kamihara
- Journal Title
  
  J. Magn. Reson.
  
  Volume: 286 Pages: 99-109
- DOI
  10.1016/j.jmr.2017.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Progress in Sensitivity-Enhanced Protein Solid-state NMR using Ultra-fast MAS and Revealing Novel Polymorphs for 42-residue Amyloid--β and other systems2021
- Author(s)
  Ishii, Yoshitaka
- Organizer
  ISMAR-APNMR
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Theoretical explanation of new solvent suppression scheme with adiabatic pulse and application for solid-state NMR experiments2021
- Author(s)
  Matsunaga, Tatsuya Okabe, Ryotaro Ishii, Yoshitaka
- Organizer
  ISMAR-APNMR
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Progress in protein solid-state NMR: applications to amyloid beta fibrils and other systems2021
- Author(s)
  Ishii, Yoshitaka
- Organizer
  分子化学討論会
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Sensitivity-enhanced protein solid-state NMR using ultra-fast MAS and structural studies of misfolded Alzheimer’s amyloid-β2021
- Author(s)
  Ishii, Yoshitaka
- Organizer
  Pacifichem 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Side-chain selective deuteration of proteins for solid-state NMR analysis2021
- Author(s)
  Terami, Hibiki Shigemitsu, Yoshiki Miyazaki, Yuki Yamazaki, Toshio Matsunaga, Tatsuya Ishii, Yoshitaka
- Organizer
  ISMAR-APNMR
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Development and Application of a High-Sensitivity Cross Polarization Scheme on Ultra-fast Magic Angle Spinning, Decoherence Optimized Tilted-Angle Cross Polarization2021
- Author(s)
  Matsunaga, Tatsuya Nakata, Kenta Matsuda, Isamu Yamazaki, Toshio Ishii, Yoshitaka
- Organizer
  ISMAR-APNMR
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Development of high efficient 13C-13C and 13C-1H magnetization transfer with band-selective CP on Ultrafast MAS.2020
- Author(s)
  Matsunaga, T., Takahashi, R. ; Ishii, Y.
- Organizer
  The 59th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan,
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Detection of structural changes by adding EGCG to Aβ(1-42) fibrils using solid-state NMR2020
- Author(s)
  Fujita, K. ; Matsuda, I. ; Ishii, Y.
- Organizer
  In The 59th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Innovation in Protein SSNMR using Ultra-fast MAS and New Polymorphs of Alzheimer's Amyloid-beta.2020
- Author(s)
  Ishii, Y.
- Organizer
  ICMRBS Web Seminar (Web conference)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Structural Differences and Novel Polymorphs of Synthetic and Brain-derived Aβ42 Fibrils by 1H-detected SSNMR2020
- Author(s)
  Wickramasinghe, A. ; Xiao, Y. ; Kobayashi, N. ; Yamazaki, T. ; Ishii, Y.
- Organizer
  In The 59th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Recent Progress in High-field Biomolecular Solid-state NMR and Beyond.2020
- Author(s)
  Ishii, Y.
- Organizer
  Yokohama NMR Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Breaking Sensitivity Boundary for High-Dimensional Protein SSNMR using Ultra-fast MAS and Structural Studies of Alzheimer's Amyloid-beta,2019
- Author(s)
  Ishii, Y. ; Kamihara, T. ; Matsuda, I. ; & Xiao, Y.
- Organizer
  EUROISMAR 2019 (Berlin, Germarny)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] In “Innovations” by High-speed-MAS SSNMR2019
- Author(s)
  Ishii, Y.
- Organizer
  ISMAR Conversation on “High-Speed Magic-Angle Spinning : What are the Advantages and Limitations?”(On-line international meeting)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Unexpected Prion-like Cross Talk between Abeta42 and Abeta40 studied by solid-state NMR2019
- Author(s)
  Ishii, Y. ; Xiao, Y. ; Yoo, B. ; Matsuda, I. ; McElheny, D.
- Organizer
  The 58-th Annual Meeting of the Nuclear Magnetic Resnance Society of Japan (Kanagawa, Japan)
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Innovations by High-Speed MAS SSNMR and SSNMR Studies of Misfolded Amyloid-β, Telluride Conference2019
- Author(s)
  Ishii, Y.
- Organizer
  Emerging Methodologies for Paramagnetic NMR and Dynamic Nuclear Polarization in Biological and Inorganic Materials (Telluride, CO, USA)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Sensitivity-Enhanced Protein Solid-state NMR using Ultra-fast MAS and Structural Studies of Alzheimer's Amyloid-β.2019
- Author(s)
  Ishii, Y.
- Organizer
  2nd India-Japan Workshop on Magnetic Resonance (Hyderabad, India)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Protein Solid-state NMR using Ultra-fast MAS and Structural Studies of Alzheimer's Amyloid2019
- Author(s)
  Ishii, Y.
- Organizer
  3rd Chinese Biomolecular NMR Meeting (Wuhan, China)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Solid-state NMR Studies of Amyloid Fibrils and Oligomers2019
- Author(s)
  Ishii, Y.
- Organizer
  5th Polish-Korean Conference on Protein Folding - Theoretical and Experimental Approaches (Soeul, Korea)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Biomolecular solid-state NMR : recent advances & applications to amyloid protein2018
- Author(s)
  石井佳誉
- Organizer
  日本分光学会NMR分光部会
- Invited
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Recent progress of high-resolution solid-state NMR : Applications to misfolded amyloid-beta proteins and graphene-based systems2018
- Author(s)
  石井佳誉
- Organizer
  理研シンポジウム「第19回分析・解析技術と化学の最先端」
- Invited
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Prion-like propagation and structural conversion of Alzheimer's amyloid-β : solid-state NMR studies2018
- Author(s)
  石井佳誉
- Organizer
  The 6th International Symposium on Drug Discovery and Design by NMR
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Solid-state NMR Studies of Graphene-based Systems and Nano-mole-scale Protein Solid-state NMR using Ultra-fast MAS2018
- Author(s)
  石井佳誉
- Organizer
  Experimental NMR conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Solid-state NMR (SSNMR) Studies of Graphene-based Systems and Nano-mole-scale Protein SSNMR using Ultra-fast MAS2018
- Author(s)
  石井佳誉
- Organizer
  ACS National Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Solid-state NMR (SSNMR) Studies of Carbon Nanomaterials and Protein SSNMR using Paramagnetic Agents2017
- Author(s)
  石井佳誉
- Organizer
  Telluride Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] Solid-state NMR (SSNMR) Studies of Misfolded β-Amyloid Assemblies and Graphen-based Nanomaterials2017
- Author(s)
  石井佳誉
- Organizer
  University of Wisconsin at Madison Chemistry Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21772
[Presentation] High-field Protein Solid-state NMR : Its Past, Present, and Prospects2017
- Author(s)
  石井佳誉
- Organizer
  理研 NMRプラットフォーム Workshop
- Invited
- Data Source
  KAKENHI-PROJECT-15K21772

1. 小林直宏 (80272160)

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2. 星美奈子 (30374010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 村松慎一 (10239543)

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4. 笹原智也 (30735345)

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5. 豊島近 (70172210)

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6. 喜井勲 (80401561)

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Ishii Yoshitaka 石井 佳誉

石井 佳誉 イシイ ヨシタカ

Research Projects

Research Products

Co-Researchers

超高分解能固体NMRと自動解析による非結晶性生体高分子と先端材料構造解析の新機軸Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next geranaration solid-state NMR methods and applications to amyloid-ligand interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Decoherenece Optimized Tilted-Angle Cross Polarization : A Novel Concept for Sensitivity-enhanced Solid-state NMR using Ultra-fast Magic Angle Spinning.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient solvent suppression with adiabatic inversion for 1H-detected solid-state NMR2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NMR-based site-resolved profiling of ホイ-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progress in proton-detected solid-state NMR (SSNMR) : Super-fast 2D SSNMR collection for nano-mole-scale proteins2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Progress in Sensitivity-Enhanced Protein Solid-state NMR using Ultra-fast MAS and Revealing Novel Polymorphs for 42-residue Amyloid--β and other systems2021

Author(s)

Organizer

Data Source

[Presentation] Theoretical explanation of new solvent suppression scheme with adiabatic pulse and application for solid-state NMR experiments2021

Author(s)

Organizer

Data Source

[Presentation] Progress in protein solid-state NMR: applications to amyloid beta fibrils and other systems2021

Author(s)

Organizer

Data Source

[Presentation] Sensitivity-enhanced protein solid-state NMR using ultra-fast MAS and structural studies of misfolded Alzheimer’s amyloid-β2021

Author(s)

Organizer

Data Source

[Presentation] Side-chain selective deuteration of proteins for solid-state NMR analysis2021

Author(s)

Organizer

Data Source

[Presentation] Development and Application of a High-Sensitivity Cross Polarization Scheme on Ultra-fast Magic Angle Spinning, Decoherence Optimized Tilted-Angle Cross Polarization2021

Author(s)

Organizer

Data Source

[Presentation] Development of high efficient 13C-13C and 13C-1H magnetization transfer with band-selective CP on Ultrafast MAS.2020

Author(s)

Organizer

Data Source

[Presentation] Detection of structural changes by adding EGCG to Aβ(1-42) fibrils using solid-state NMR2020

Author(s)

Organizer

Data Source

Ishii Yoshitaka 石井佳誉

石井佳誉イシイヨシタカ