Fang Zhenzhou 方震宙

Researcher Number	40963806
Other IDs
Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator DNA損傷応答 / タンパク質分解 / BRCA1 / ユビキチン化 / 中心体 Except Principal Investigator がん治療 / ゲノム不安定性 / DNA損傷 / がん / 中心体

Aurora Aのユビキチン化リガーゼ活性を介したBRCA1関連分子の中心体制御機構の解明Principal Investigator
- Principal Investigator
  
  方震宙
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of cancer therapy targeting genome instability by centrosome dysregulation and DNA damage
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University

All 2024 2023 2022

All Journal Article Presentation Book

[Book] New functions of BRCA1/2 in regulating carcinogenesis and drug sensitivity. Practical Guide to Hereditary Breast and Ovarian cancer - Annual meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer2023
- Author(s)
  Fang Zhenzhou、Yoshino Yuki、Chiba Natsuko
- Total Pages
  17
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K24157
[Journal Article] Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification2024
- Author(s)
  Yoshino Yuki、Ogoh Honami、Iichi Yudai、Sasaki Tomohiro、Yoshida Takahiro、Ichimura Shiori、Nakayama Masahiro、Xi Wu、Fujita Hiroki、Kikuchi Megumi、Fang Zhenzhou、Li Xingming、Abe Takaya、Futakuchi Mitsuru、Nakamura Yasuhiro、Watanabe Toshio、Chiba Natsuko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1870 Issue: 5 Pages: 167138-167138
- DOI
  10.1016/j.bbadis.2024.167138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24157
[Journal Article] Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro2024
- Author(s)
  Fang Zhenzhou、Li Xingming、Yoshino Yuki、Chiba Natsuko
- Journal Title
  
  STAR Protocols
  
  Volume: 5 Issue: 2 Pages: 103008-103008
- DOI
  10.1016/j.xpro.2024.103008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14584, KAKENHI-PROJECT-23K24157
[Journal Article] The centrosome: a critical hub for cell cycle regulation2024
- Author(s)
  Yoshino Yuki、Fang Zhenzhou、Chiba Natsuko
- Journal Title
  
  Trends in Cell Biology
  
  Volume: - Issue: 6 Pages: 437-439
- DOI
  10.1016/j.tcb.2024.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24157
[Journal Article] Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation2023
- Author(s)
  Fang Zhenzhou、Li Xingming、Yoshino Yuki、Suzuki Moe、Qi Huicheng、Murooka Hinari、Katakai Riko、Shirota Matsuyuki、Mai Pham Thi Anh、Matsuzawa Ayako、Otsuka Kei、Ishioka Chikashi、Mori Takahiro、Chiba Natsuko
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 8 Pages: 112850-112850
- DOI
  10.1016/j.celrep.2023.112850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14584, KAKENHI-PROJECT-22K12241, KAKENHI-PROJECT-23K24157
[Journal Article] <scp>BRCA1</scp> transports the <scp>DNA</scp> damage signal for <scp>CDDP</scp> ‐induced centrosome amplification through the centrosomal Aurora A2022
- Author(s)
  Qi Huicheng、Kikuchi Megumi、Yoshino Yuki、Fang Zhenzhou、Ohashi Kazune、Gotoh Takato、Ideta Ryo、Ui Ayako、Endo Shino、Otsuka Kei、Shindo Norihisa、Gonda Kohsuke、Ishioka Chikashi、Miki Yoshio、Iwabuchi Tokuro、Chiba Natsuko
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4230-4243
- DOI
  10.1111/cas.15573
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07143, KAKENHI-PROJECT-23K24157
[Presentation] BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK12023
- Author(s)
  Zhenzhou Fang, Risa Kobayashi, Tse-chin Hsiao, Yuki Yoshino, Huicheng Qi, Natsuko Chiba
- Organizer
  The 82nd Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-23K14584
[Presentation] BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK1.2023
- Author(s)
  Fang Z, Kobayashi R, Hsiao T, Yoshino Y, Qi, H and Chiba N.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1-interacting protein BARD1 suppresses the OLA1 polyubiquitination by Aurora A for centrosome maturation2023
- Author(s)
  Zhenzhou Fang, Xingming Li, Hinari Murooka, Minori Watanabe, Mai Morooka, Rin Oya, Yuki Yoshino, Natsuko Chiba
- Organizer
  The 18th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14584
[Presentation] BARD1 suppresses the OLA1 polyubiquitination by Aurora A to regulate centrosome maturation.2023
- Author(s)
  Li X, Fang Z, Murooka H, Watanabe M, Yoshino Y, Mori T, and Chiba N
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] Aurora A ubiquitinates the BRCA1-interacting protein OLA1 to regulate centrosome maturation2023
- Author(s)
  千葉奈津子, 方震宙, 李星明, 吉野優樹, 森隆弘.
- Organizer
  第46回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1-associated protein RACK1 regulates centrosome duplication in breast cancer cells.2023
- Author(s)
  Yoshino Y, Fang Z, and Chiba N
- Organizer
  第8回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1 is involved in the ubiquitination of OLA1 by Aurora A to promote centrosome maturation.2022
- Author(s)
  Li X, Fang Z, Yoshino Y, Ishioka C, Mori T, and Chiba N.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] NEK2 regulates centrosome number through promoting OLA1 ubiquitination by Aurora A.2022
- Author(s)
  Fang Z, Li X, Yoshino Y, Ishioka C, Mori T, and Chiba N.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157

1. 千葉奈津子 (50361192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. 城田松之 (00549462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉野優樹 (60755700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. 渡部剛 (70451573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Fang Zhenzhou 方 震宙

Research Projects

Research Products

Co-Researchers

Aurora Aのユビキチン化リガーゼ活性を介したBRCA1関連分子の中心体制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cancer therapy targeting genome instability by centrosome dysregulation and DNA damage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] New functions of BRCA1/2 in regulating carcinogenesis and drug sensitivity. Practical Guide to Hereditary Breast and Ovarian cancer - Annual meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The centrosome: a critical hub for cell cycle regulation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>BRCA1</scp> transports the <scp>DNA</scp> damage signal for <scp>CDDP</scp> ‐induced centrosome amplification through the centrosomal Aurora A2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK12023

Author(s)

Organizer

Data Source

[Presentation] BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK1.2023

Author(s)

Organizer

Data Source

[Presentation] BRCA1-interacting protein BARD1 suppresses the OLA1 polyubiquitination by Aurora A for centrosome maturation2023

Author(s)

Organizer

Data Source

[Presentation] BARD1 suppresses the OLA1 polyubiquitination by Aurora A to regulate centrosome maturation.2023

Author(s)

Organizer

Data Source

[Presentation] Aurora A ubiquitinates the BRCA1-interacting protein OLA1 to regulate centrosome maturation2023

Author(s)

Organizer

Data Source

[Presentation] BRCA1-associated protein RACK1 regulates centrosome duplication in breast cancer cells.2023

Author(s)

Organizer

Data Source

[Presentation] BRCA1 is involved in the ubiquitination of OLA1 by Aurora A to promote centrosome maturation.2022

Author(s)

Organizer

Data Source

[Presentation] NEK2 regulates centrosome number through promoting OLA1 ubiquitination by Aurora A.2022

Author(s)

Organizer

Data Source

Fang Zhenzhou 方震宙