OHSHIMA Norio 大島宣雄

Researcher Number	50015971
External Links
Affiliation (Current)	2022: 筑波大学, 医学医療系(名誉教授), 名誉教授
Affiliation (based on the past Project Information) *help	2000 – 2003: 筑波大学, 基礎医学系, 教授 1992 – 1997: 筑波大学, 基礎医学系, 教授 1986 – 1990: 筑波大学, 基礎医学系, 教授 1986: Institute of Basic Medical Sciences, University of Tsukuba, 基礎医学系, 教授 1985: 筑波大学, 基医, 教授
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Circulatory organs internal medicine / 生物・生体工学 / Biomedical engineering/Biological material science / 医学一般 Except Principal Investigator Biomedical engineering/Biological material science / Circulatory organs internal medicine / Digestive surgery / 医学一般 / Obstetrics and gynecology
Keywords	Principal Investigator 微小循環 / 白血球 / バイオメカニクス / 血行力学 / レオロジー / 血小板血栓 / 肝細胞 / 人工肝臓 / fMLP / 血管新生 … More / 血流動態 / Microcirculation / 血小板 / 血管内皮細胞 / 血小板、 / 内皮細胞、 / 抗血栓性、 / ずり応力可変型培養器、 / 心筋 / エンドセリン / カルシトニン遺伝子関連ペプチド、 / ランゲンドルフ潅流心 / 心筋、 / 微小循環、 / エンドセリン、 / カルシトニン遺伝子関連ペプチド / 冠循環 / myocardium / microcirculatin / calcitonine gene related protein / endothelin-1 / Langendorf's perfusion / ハイブリッド型人工肝臓 / 高密度培養 / 充填層型バイオリアクター / ployvinyl formal樹脂 / polyvinyl formal樹脂 / 充てん層型バイオリアクター / ポリビニールホルマール樹脂多孔質体 / 充填層型リアクター / 人工臓器 / hybrid-type aftificial liver support system / high density culture / reticulated polyvinyl formal resin / packed-bed type bioreactor / hepatocyte / 腹膜播種性腫瘍モデル / 蛍光トレーサー法 / Fischer344系ラット / 腸間膜 / 共焦点レーザ走査型顕微鏡 / 蛍光トレーサ法 / 腫瘍 / 腹膜播種性腫瘍 / Hortonの法則 / peritoneal disseminated tumor model / fluorescent tracer / Fischer 344 rat / peritoneum / white blood cell / confocal laser scannity microscopy / 腫瘍微小循環 / 一酸化窒素 / 共焦点レーザー走査型顕微鏡 / 生体顕微鏡 / tumor microcirculation / hemodynamics / angiogenesis / nitric oxide / confocal laser-scanning microscope / intravital microscope / leukocyte / 造血幹細胞 / ストローマ細胞 / 胎仔肝臓細胞 / 人工骨髄 / 分化・増殖 / 三次元培養 / 多孔質樹脂 / ティッシュ・エンジニアリング / 造血細胞 / 胎子肝臓細胞 / 共培養 / シグナル分子 / hematopoietic stem cell / stromal cell / fetal liver cell / artificial bone marrow / growth / differentiation / three-dimensional culture / porous scaffold / tissue engineering / 回転円板型 / 細胞培養 / 肝不全 / 肝機能補助 / マイクロカプセル / アルギン酸カルシウム / Artificial Liver / Rotating Disc / Cell Culture / Hepatocyte / Hepatic Failure / Hepatic Support / Microencapsulation / 蛍光色素 / 光化学反応 / 活性酸素 / プロスタグランディン / Fluorescent Dye / Platelet Thrombus / Photochemical Reaction / Active Oxygen / Leucocytes / Hemodynamics / 深部微小血管 / 近赤外蛍光 / インドシアニングリ-ン / 半導体レ-ザ / 血漿タンパク質 / 赤外蛍光顕微鏡システム / ICG / ラット潅流心 / Deep Microvasculature / Near-infrared Fluorescence / Indocyanine Green / Semi-conductor Laser … More Except Principal Investigator tissue engineering / α-amanitine / lipopolisaccharide / 肝細胞 / 内皮細胞 / 灌流培養 / 血管内皮細胞 / バイオ人工肝臓 / ブタ / 劇症肝不全 / 充填層型バイオリアクタ / 生存時間 / アンモニア / 動物モデル / 糖尿病 / 赤血球変形能 / 血糖値 / 細小血管症 / 培養内皮細胞 / せん断応力 / 物質透過性 / 細胞骨格 / マイクロフィラメント / 力学的性質 / 血小板血栓 / 光-色素反応 / oncostatin M / hepatocyte / three-dimensional culture / 微小循環 / 物質代謝 / 局所血流 / 分子生物学 / 医工学 / 血管傷害 / 血行力学 / 酸素輸送 / 静脈血酸素分圧 / Asphyxia / Ligature strangulation / Pulmonary congestion / Adrenaline / Noradrenaline / 細胞外マトリックス / 動脈硬化 / Cultured endothelial cell / Cytoskeleton / Shear stress / Extracellular matrix / Atherosclerosis / Mechanical property / Platelet thrombus / 肝細胞高密度培養 / 充填層型リアクタ / ポリビニルホルコール樹脂多孔質体 / Bioartificial liver / Porcine / Fulminant hepatic failure / Packed-bed type reactor / High-density culture of hepatocytes / Ammonium / 人工肝臓 / 骨髄 / 胎児 / onocostatin M / 3次元培養 / 造血 / artificial liver / bone marrow / fetus / hematopoiesis / 胎仔肝臓細胞 / シグナル分子 / 三次元培養 / 多孔質樹脂 / 充填層型リアクター / ティッシュ・エンジニアリング / ブタ胎仔肝臓細胞 / fetal liver cell / signaling molecule / perfusion culture / porous scaffold / packed-bed reactor / 再生医工学 / 人工血管 / 血管平滑筋細胞 / 骨髄細胞 / ナノフィルム / 傷害修復 / コンプライアンス / 細胞増殖 / 細胞遊走 / vessel graft / vascular endothelial cell / vascular smooth muscle cell / bone marrow cell / nanofilm / injury repair / 水中哺育 / 膜型人工肺 / A-Vバイパス法 / V-Aバイパス法 / 自動制御システム / 胎仔血管造影検査 / 人工子宮 / 体外循環 / Artificial placenta / Extracorporeal circulation / A-V bypass / V-A bypass / Fetal angiography / Auto-regulation system / Membrane oxygenator / 非酵素的糖化 Less

Development of tissue-engineered artificial immune systemPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Hirotoshi, 大島宣雄
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
ブタ劇症肝炎モデルの確立と人工肝補助療法による治療効果の検討Principal Investigator
- Principal Investigator
  
  大島宣雄, 柳健一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
Development of a tissue-engineered bioartificial liver utilizing immature cells
- Principal Investigator
  
  MIYOSHI Hirotoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
Selective induction of undifferentiated cells to vascular cells by tissue engineering methods
- Principal Investigator
  
  OOKAWA Keiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
Effect of Tumor-Specific Leukocyte Behavior on Tumor GrowthPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
Development of the packed-bed type bioartificial liver
- Principal Investigator
  
  YANAGI Kennichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
Regeneration of immature tissue (fetal liver) functions utilizing a tissue-engineering approach
- Principal Investigator
  
  MIYOSHI Hirotoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
人工材料表面における血管内皮細胞の増殖動態と細胞機能の新しい評価法
- Principal Investigator
  
  鎮西敬子 (大川敬子)
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
Biomechanical study on the process of neovascularization in tumor tissuesPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
血管内皮細胞と血球成分の相互作用のメカニクス:ずり応力可変型培養器を用いた検討Principal Investigator
- Principal Investigator
  
  大島宣雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
血管内皮細胞と白血球の相互作用に関するバイオメカニクスPrincipal Investigator
- Principal Investigator
  
  大島宣雄
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
Hemodynamic effect of vasoactive peptides on miocardial microvasculaturePrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  University of Tsukuba
Development of a new hybrid-type aftificial liver support system using packed-bed type reactorPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  University of Tsukuba
微小循環系における白血球と血小板の挙動のバイオメカニクスPrincipal Investigator
- Principal Investigator
  
  大島宣雄
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
臓器微小循環と物質代謝及びその障害に関する分子生物学的・医工学的研究
- Principal Investigator
  
  神谷瞭
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医学一般
- Research Institution
  Hokkaido University
Roles of Cytoskeletal Components for the Orientation and the Permeability of Cultured Endothelial Cells Exposed to Shear Stress
- Principal Investigator
  
  SATO Masaaki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
窒息屍内臓うっ血の成因
- Principal Investigator
  
  古屋義人, 佐藤正明
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Occupational and Environmental Health, Japan
  University of Tsukuba
ANALYSIS OF MICROCIRCULATORY HEMODYNAMICS IN MYOCARDIUM USING A NEW INTRAVITAL NEAR-INFRARED FLUORESCENCE MICROSCOPE SYSTEMPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
糖尿病性細小血管症早期診断, 予防における赤血球変形能測定の意義
- Principal Investigator
  
  菊池佑二
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
糖尿病患者における赤血球変形能の計測とその病態生理学的意義
- Principal Investigator
  
  KIKUCHI Yuji
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Kinetic Studies of Intravascular Thrombus Formation Using Newly Developed Thrombus Model in MicrovesselsPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tsukuba
Establishment of intra-water Management of Gaat Fetus. (Extracorporeal Circulation using Membrane Oxygenator)
- Principal Investigator
  
  IWASAKI Hirokazu
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  University of Tsukuba
Development of A Hybrid-type Artificial Liver Utilizing Isolated HepatocytesPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Norio
- Project Period (FY)
  1984 – 1985
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  医学一般
- Research Institution
  University of Tsukuba

All 2005 2004 2003

All Journal Article

[Journal Article] Oncostatin M stimulates proliferation and functions of mouse fetal liver cells in three-dimensional cultures2005
- Author(s)
  Ehashi T, Miyoshi H, Ohshima N
- Journal Title
  
  Journal of Cellular Physiology 202(3)
  
  Pages: 698-706
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200033
[Journal Article] Perfusion of medium with supplemented growth factors changes metabolic activities and cell morphology of hepatocyte/nonparenchymal cell co-culture2004
- Author(s)
  Kan P, Miyoshi H, Ohshima N
- Journal Title
  
  Tissue Engineering 10(9/10)
  
  Pages: 1297-1307
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200033
[Journal Article] Tissue engineering application of 3-D cultured cells2003
- Author(s)
  Miyoshi H, Ohshima N
- Journal Title
  
  Bioscience and Industry (in Japanese) 61(7)
  
  Pages: 477-478
- NAID
  10011624129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200033
[Journal Article] 三次元培養細胞の再生医工学への応用2003
- Author(s)
  三好浩稔, 大島宣雄
- Journal Title
  
  バイオサイエンスとインダストリー 61(7)
  
  Pages: 477-478
- NAID
  10011624129
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200033
[Journal Article] バイオ人工臓器の開発と再生医工学2003
- Author(s)
  大島宣雄, 三好浩稔
- Journal Title
  
  化学工業 54(1)
  
  Pages: 42-46
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15200033
[Journal Article] Development of bioartificial liver and tissue engineering2003
- Author(s)
  Ohshima N, Miyoshi H
- Journal Title
  
  Chemical Industry (in Japanese) 54(1)
  
  Pages: 42-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15200033

1. OOKAWA Keiko (30251052)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. MIYOSHI Hirotoshi (70292547)

# of Collaborated Projects: 10 results

# of Collaborated Products: 6 results
3. YANAGI Kennichi (70239797)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. SATO Masaaki (30111371)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. KIKUCHI Yuji (20002107)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TANIGUCHI Hideki (70292555)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FUKUDA Hideki (30263396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKADA Yasutsugu (10272197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IWASAKI Hirokazu (40045951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKI Junichi (50187118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MESAKI Noboru (30010408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 神谷瞭 (50014072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大橋俊夫 (80020832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 古川俊之 (20101082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 真崎知生 (60009991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 林紘三郎 (90026196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 古屋義人 (40013841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 北敏郎 (00131912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KANAMORI Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 三好浩捻

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHSHIMA Norio 大島 宣雄

Research Projects

Research Products

Co-Researchers

Development of tissue-engineered artificial immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ブタ劇症肝炎モデルの確立と人工肝補助療法による治療効果の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of Tumor-Specific Leukocyte Behavior on Tumor GrowthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biomechanical study on the process of neovascularization in tumor tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管内皮細胞と血球成分の相互作用のメカニクス:ずり応力可変型培養器を用いた検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

血管内皮細胞と白血球の相互作用に関するバイオメカニクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Hemodynamic effect of vasoactive peptides on miocardial microvasculaturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new hybrid-type aftificial liver support system using packed-bed type reactorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

微小循環系における白血球と血小板の挙動のバイオメカニクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

OHSHIMA Norio 大島宣雄