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HIGUTI Tomihiko
樋口 富彦
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Alternative Names
HIGUCHI Tomihiko 樋口 富彦
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Researcher Number
50035557
Other IDs
External Links
Affiliation (based on the past Project Information)
*help
2007 – 2008: The University of Tokushima, Institute of Health Biosciences, Graduate School, professor
2007: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授
2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2004 – 2005: The University of Tokushima, Graduate School Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授
1999 – 2003: 徳島大学, 薬学部, 教授
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1994 – 1997: 徳島大学, 薬学部, 教授
1987 – 1993: 徳島大学, 薬学部, 助教授
1988: 徳島大学, 楽学部, 助教授
1986: Pharmaceutical Sciences, Tokushima Univ. Associate Professor, 薬学部, 助教授
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Review Section/Research Field
Principal Investigator
Functional biochemistry
/
代謝生物化学
/
Science and Engineering
/
Functional biochemistry
/
物質生物化学
/
広領域
Except Principal Investigator
Biological Sciences
/
General internal medicine (including Psychosomatic medicine)
/
Metabolomics
/
Morphological basic dentistry
Keywords
Principal Investigator
ミトコンドリア / ATP合成酵素 / エネルギー変換 / subunit b / バイオジェネシス / MRSA / JVS / チャージリン / 形態形成 / 蛍光蛋白質
…
More
/ HeLa / 細胞 / ディファレンシャル / ディスプレイ / 生体エネルギー / URFA6L / ミトコンドリアDNA / ATP synthase / flavone / フラボン / 制癌剤 / 細胞内情報伝達系 / 遺伝子 / シス-要素 / トランス作働性因子 / 転写調節 / 遺伝子発現制御 / JVSマウス / Differential Display / 選択毒性 / 異方性阻害剤 / Mitochondria / biogenesis / mitochondria / 生薬 / β-ラクタム剤-感受性誘導薬 / gallic acid / xanthatin / vraR ＆ vraS / 構造活性相関 / Chargerin / Mitochondrial DNA / 抗がん剤 / エネルギー代謝 / 転写制御 / カルシウム / 分子シンクロナイゼイション / cDNAマイクロアレイ / HeLa細胞 / ディファレンシャルディスプレイ / 細胞周期 / ミトコンドリア遺伝子 / 一次構造 / シスプラチン / ヒト乳癌(MXー1) / 癌診断薬 / Sarcoma180 / 白血病由来細胞(P388) / Anticancer drug / Selective toxicity / Anisotropic inhibitor / Cisplatin / Human brease cancer (MX-1) / 老化 / シス要素 / エンハンサー / ヒト遺伝子 / subunit b遺伝子 / Sp1 / BTEB / エンハンサー45K / エンハンサー70K / transcriptional regulation / Aging / enhancer / コンデンサー仮説 / 化学浸透圧説 / リピド平面二重膜 / 膜電位 / サブユニットe / 電気生理 / テトラゾリウム / 活性制御 / parallel condenser model / bioenergetics / chemosmotic model / anisotropic inhibitor / planner bilayr membrane / H^+-pump / surface potential / tetrazlium / 高度耐性MRSA / 抗菌活性物質 / β-ラクタム剤 / 半枝蓮 / Apigenin / Gallic acid / ガロイル基 / 菌体外分泌物質 / 訶子 / 蒼耳 / Ethyl gallate / Xanthatin / highly resistant MRSA / crude drugs / antimicrobial agents / beta-lactam antibiotics / beta-lactam-sensitizers / falvone / 薬剤耐性 / Differential Hybridization / two-comonentsignal transduction / MRSA感染マウス / b-ラクタム剤-感受性誘導薬 / vraR / vraS / two-component signal transduction system / mecA mRNA / PBP2' / 転写制禦系 / 耐性遺伝子 / β-ラクタム剤耐性遺伝子 / mecA / drug resistance / differential hybridization / two component signal transduction / systemic infection in mice / inducers of β-lactam-susceptibility in MRSA (ILSMR) / カルニチン / 網状ミトコンドリア / フュソジェン / シトクロム / H^+-ATP合成酵素 / JVS mouse / carnitin / mitochondrial reticulum / fusogen / time-laps deconvolution / cytochrome / 薬用植物 / β-ラクタム剤-感受性増強効果 / ハイスループット・スクリーニング / アルキルガレート / 二成分系シグナルトランスダクション / 岩白菜 / 最適炭素鎖長 / 親水性基と疎水性基 / 生薬植物 / β-ラクタム剤-感受性増強薬 / ハイ・スループット・スクリーニング / SAR解析 / 好気的エネルギー産生 / ストレスに対する抵抗性 / medicinal plants / intensifier of β-lactam-susceptibility / high throughput screening / alkyl gallate / structure-activity relationship / two-components signal transduction system / chargerin / 進化 / Bioenergetics / Energy Transduction / エネルギ-変換 / チャ-ジリン / プロトンポンプ / サブユニットb / 遺伝子操作 / Energy transduction / Proton pump / Molecular cloning
…
More
Except Principal Investigator
H^+-ATP合成酵素 / ミトコンドリア / gene chip / rpoS / rpoN / pvdS / vqsR / 導電性酵素膜 / カルモジュリンハイブリッド / 比蛍光面像法 / 細胞内カルシウム / 非天然アミノ酸ポリペプチド / 光制御抗原抗体反応 / H_+ーATP合成酵素 / インポ-トプレカ-サ / 活性可変酵素 / 細胞知覚 / 抗ピレニルアラニル抗体 / H^+ーATP合成酵素 / ニオイセンサ- / 分子間情報伝達材料 / 粘菌内リン脂質組成変動 / 光・電子機能タンパク質 / ラット肝H^+-ATP合成酵素 / ハロロドプシン光電変換デバイス / 自己組織化 / 脂質修飾抗体 / ナノ会合体 / リゾチーム / アパタイト / タリン / リポソーム / カルモジュリン / 融合タンパク質 / 自己組織化能 / 高分子ヘテロ構造体 / 光駆動リン酸化システム / 分子系超構造 / バイオ素子 / バイオセンサ / 分子組織 / 血管内皮細胞 / 血管新生 / 血管新生阻害剤 / 癌転移 / 伝承医薬 / 民間医療 / 少数民族薬物 / 天然物化学 / 伝統薬物調査 / 雲南省 / 伝承薬物 / 民間薬 / 生薬学 / 伝承医薬品 / 中国雲南省 / JVSマウス / 低血糖症 / インフルエンザ / カルニチン / OCTN2 / 長鎖脂肪酸 / JVS マウス / OCTN 2 / Gene Chip / インフルエンザウイルス / インフルエンザ脳症 / JVS mouse / hypoglycemia / influenza / carnitine / OCTN-2 / mitochondria / fatty acid / 抗菌薬抵抗性 / ストレス応答 / 付着細菌 / ppGpp / 付着 / 緑膿菌 / quorum sensing / 遺伝子発現 / pyoverdine / tolerance / 抗菌薬 / tcp gene / Pseudomonas aeruginosa / antibiotic tolerance / stress response / adherent bacteria / ppGppc
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Research Projects
(
28
results)
Co-Researchers
(
40
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Second survey on the folk medicine of minority groups in Yunnan Province of China, and a study about its utilization
Principal Investigator
TAKAISHI Yoshihisa
Project Period (FY)
2006 – 2008
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General internal medicine (including Psychosomatic medicine)
Research Institution
The University of Tokushima
Molecular analysis of anteliotic-tolerance and stress response in adherent bacteria
Principal Investigator
ONO Tsuneko
Project Period (FY)
2005 – 2007
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Morphological basic dentistry
Research Institution
The University of Tokushima
JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
2003
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver
Principal Investigator
KUWAJIMA Masamichi
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Metabolomics
Research Institution
The University of Tokushima
ミトコンドリア増生の分子シンクロナイゼイションと新規蛋白質因子の解析
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Science and Engineering
Research Institution
The University of Tokushima
JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
2002
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
TITLE OF PROJECT : Invention of intensifiers of antibiotics-susceptibility against multi-drugs resistant pathogenic bacteria and invesrigation for novel control system of multi-drugs resistance
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
広領域
Research Institution
The University of Tokushima
血管新生をターゲットにした癌悪性化阻止戦略―血管内皮細胞膜に存在するH^+-ATP合成酵素阻害剤のスクリーニングと癌治療への応用―
Principal Investigator
新垣 尚捷
Project Period (FY)
2001
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section
Biological Sciences
Research Institution
The University of Tokushima
Novel factors in the biogenesis of mitochondrial reticulum found from heart of juvenile visceral steatosis mouse
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
ATP合成酵素の分子構築における遺伝子制御の分子シンクロナイゼイション機構
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Review Section
Science and Engineering
Research Institution
The University of Tokushima
Development of "induces of β-lactam-susceptibility in MRSA (ILSMR)" and elucidaton of the novel regulatory mechanism
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
生体分子素構造の人工的組織構造化による新機能発現
Principal Investigator
相澤 益男
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo Institute of Technology
Mitochondrial H^+-ATP synthase as a Paralled Condenser
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Faculty of Pharmaceutical Sciences, The University of Tokushima
Studies on new antimicrobial agents from crude drugs against nosocomial methicillin-resistant Staphylococcus aureus
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
Transcriptional regulation proteins of human ATP synthae subunit b gene
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Functional biochemistry
Research Institution
Faculty of Pharmaceutical Sciences, The University of Tokushima
ミトコンドリアATP合成酵素-分子構築,エネルギー変換とCa制御の分子機作の解明
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokushima
ヒトH^+-ATP合成酵素subunit b遺伝子の発現制御に係る蛋白質因子の解析
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional biochemistry
Research Institution
The University of Tokushima
生体情報・エネルギー変換分子材料の設計および機能制御
Principal Investigator
相澤 益男
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo Institute of Technology
抗がん剤の効果増強の新システムの開発
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokushima
ミトコンドリアH^+-ATP合成酵素の分子構築とエネルギー変換機作
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokushima
ヒトH±ATP合成酵素のsubunitb遺伝子の発現制御機作
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
代謝生物化学
Research Institution
The University of Tokushima
生体情報・エネルギ-変換分子材料の設計および機能制御
Principal Investigator
相澤 益男
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo Institute of Technology
生体情報・エネルギ-変換分子材料の設計および機能制御
Principal Investigator
相澤 益男
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Tokyo Institute of Technology
Developmental research of selective toxic anticancer drug and cancer-diagnose drug targeting cancer mitochondria
Principal Investigator
Principal Investigator
HIGUCHI Tomihiko
Project Period (FY)
1989 – 1991
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
代謝生物化学
Research Institution
Tokushima University
チャージリンーその三次構造の解明とエネルギー変換機作の研究
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokushima
CHARGERIN---ITS TERTIARY STRUCTURE AND THE MECHANISM OF ENERGY TRANSDUCTION
Principal Investigator
Principal Investigator
HIGUTI Tomihiko
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
代謝生物化学
Research Institution
TOKUSHIMA UNIVERSITY
チャージリンーその分子構造とエネルギー変換機作の研究
Principal Investigator
Principal Investigator
樋口 富彦
Project Period (FY)
1987
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
物質生物化学
Research Institution
The University of Tokushima
Chargerins which generate Negative Charges on the Outer Surface of Mitochondrial Inner Membrane
Principal Investigator
Principal Investigator
HIGUTI T.
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
代謝生物化学
Research Institution
Tokushima University
# of Projects (Dsc)
# of Projects (Asc)
1.
SHIBATA Hirofumi
(00093865)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
2.
ARAKAKI Naokatu
(60151148)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
3.
KUWAJIMA Masamichi
(00205262)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
相澤 益男
(00016742)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
宍戸 昌彦
(60026268)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
上田 哲男
(20113524)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
SATO Yoichi
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
TAKAISHI Yoshihisa
(60035558)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
KAWAZOE Kazuyoshi
(00248296)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
MURAKAMI Kotarou
(10035553)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
KASHIWADA Yoshiki
(30169429)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
TERADA Hiroshi
(00035544)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
KUDO Kioshi
(50144978)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
ISHIMURA Kazunori
(90112185)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
SHINOHARA Yasuo
(60226157)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
TSUKAGUCHI Hiroyasu
(60335792)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
ONO Tsuneko
(40035514)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
MIYAKE Yoichiro
(80136093)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
ABIKO Yoshimitsu
(70050086)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
KUWAHARA Tomomi
(60263810)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
KAYAMA Shizuo
(50432761)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
栗原 堅三
(00016114)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
久保 いづみ
(40214986)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
北川 幸己
(60093853)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
宝谷 紘一
(80025444)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
小久保 正
(30027049)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
片岡 一則
(00130245)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
上野 明道
(80136267)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
村上 圭史
(10335804)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
HAO Xiaojiang
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
LI Shunlin
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
XIE Lishan
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
YANAGI Yoshikazu
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
KRAAYENHOF Ruud
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
DEVENSH R.J
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
NAGLEY Phillip
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
SHINGYOUCHI Ken-ichi
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
SHIKISHIMA Yasuhiro
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
PONNAPPA B.C
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
PONNAPPA Biddanda C
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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