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Nakae Taiji  中江 太治

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NAKAE Taiji  中江 太治

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Researcher Number 50102851
Other IDs
External Links
Affiliation (Current) 2025: 北里大学, 大村智記念研究所, 研究員
Affiliation (based on the past Project Information) *help 2005: Tokai University, Institute of Medical Science, Professor, 総合医学研究所, 教授
1993 – 2004: 東海大学, 医学部, 教授
1986 – 1991: 東海大学, 医学部, 教授
1986: 東海大, 医学部, 教授
Review Section/Research Field
Principal Investigator
Bacteriology (including Mycology) / 細菌学 / Biological Sciences / Structural biochemistry
Except Principal Investigator
細菌学
Keywords
Principal Investigator
薬剤耐性 / 緑膿菌 / 抗生物質 / 排出 / 膜蛋白 / 外膜 / 排出ポンプ / Pseudomonas / 耐性 / 細胞膜 … More / 細菌 / Membrane protein / 透過性 / 異物 / ポンプ / 膜蛋白質 / bacteria / 多剤耐性 / 人工膜 / 透過孔 / 院内感染 / antibiotic / transporter / RND / MexB / 膜貫通領域 / トランスポーター / 薬物 / Efflux / Pump / 異物排出 / 輸送 / トポロジー / membrane protein / cell membrane / efflux / Antibiotic resistance / ポーリン / extrusion pump / permeability / drug resistance / Reconstitution / Drug resistance / Outer membrane / ポ-リン / 日和見感染 / 排除限界 / X線解析 / 結晶 / pore / barrier / opportunistic infection / gram-negative pathogen / outer membrane / 孔 / 細菌膜 / Psudomonas / xenobiotic antibiotic / efflux pump / 変異体 / エネルギー / 結晶構造 / 抗生物質・異物 / membrane proteins / drug / resistance / pump / RND-ファミリー / MexAB-OprM / 基質認識 / Infection / X-ray diffraction / Crystal / Antibiotics / X線回析 / X-線結晶回析 / X-線結晶解析 / Transport / Membrane / Membrane topology / 生体防御 / MDR / druq resistance / antibiotics / 薬剤排出 / Channel / Porin / Lipid bilayr / Pseudomonas aeruginosa / 脂質平面膜 / イミペネム / OprD2 / チャンネル / beta-lactamase / antibiotic target / active afflux / membrane / クローニング / beta-ラクタマーゼ / 膜 / MRSA / 病院内感染 / 細菌感染 / 楽剤耐性 / 消毒薬 / 薬剤 / 薬剤標的 / 修飾酵素 / 能動排出 / 膜透過 / Cloning / Planar membrane / Liposome / Permeability / リポソ-ム / 再構成 / クロ-ニング / 平面膜 / 構造解析 / 外膜蛋白 / 膜輸送 … More
Except Principal Investigator
Listerial infection / Enterotoxigenic E. coli / Lipoteichoic acids / Lipopolysaccharides / Cord factor / Mycoloyl glycolipids / Opportunistic pathogen / Outer membrane permeability / 感染防御抗原 / 薬剤透過障害因子 / 病原細菌定着因子 / リポ多糖 / 両親媒性物質 / テイコ酸 / 細胞膜脂質 / 細菌表層タン白質 / 細菌細胞構成的病原因子 / 細胞壁脂質 / 細胞壁両親媒性物質 / 細菌表層蛋白質(外膜蛋白質) / 生体防禦調節物質 / 感染要員 / 細菌細胞壁表層物質 / リステリア感染 / 毒素源性大腸菌 / リポテイコ酸 / グラム陰性菌リポ多糖体 / コ-ドファクタ- / ミコ-ル酸含有糖脂質 / 日和見病原菌 / 外膜透過性 / muramyl dipeptide / invasion / colonization / fimbriae / Virulence / Cell surface / 生理活性物質 / ミコール酸 / リポタイコ酸 / α毒素 / 線毛 / 侵入因子 / 表層構造 / 付着因子 / 侵入性 / MDP / Lps / モノクローナル抗体 / 細胞壁タンパク / 紋毛 / 定着因子 Less
  • Research Projects

    (13 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (25 People)
  •  異物、薬物排出ポンプ蛋白の結晶解析と機能Principal Investigator

    • Principal Investigator
      中江 太治
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Structure and function of the xenobiotic-antibiotic extrusion transportersPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Structure and function of the xenobiotic-multidrug efflux pumpPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokai University
  •  Structure and Function of the Antibiotic-Specific ChannelPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Structural biochemistry
    • Research Institution
      Tokai University
  •  The xenobiotic efflux pumps and multiantibiotic resistance in Pseudomonas aeruginosaPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokai University
  •  Gene expression and protein analysis of the antibiotic extrusion pump in Pseudomonas aeruqinosPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokai University School of Medicine
  •  Involvement of bacterial membranes in drug resistancePrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokai University
  •  The permeability specificity of the imipenem-specific channel of OprD2 in Pseudomonas aeruginosaPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Tokai University School of Medicine
  •  Role of the outer membrane permeability in the antibiotic resistance in Pseudomonas aerugionsaPrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      細菌学
    • Research Institution
      Tokai University
  •  Co-operative Research Study on Bacterial Surface Molecules and Bioresponse Modifying Activities in Host Animals.

    • Principal Investigator
      YANO Ikuya
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      細菌学
    • Research Institution
      Osaka City University
  •  Role of the outer membrane of gram-negativebacteria in the intrinsic drug resistancePrincipal Investigator

    • Principal Investigator
      NAKAE Taiji
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokai University School of Medicine
  •  緑膿菌外膜の透過孔と抗生物質透過性の関連Principal Investigator

    • Principal Investigator
      中江 太治
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      細菌学
    • Research Institution
      Tokai University
  •  The group studies on the structural and functional roles of the bacterial surfaces in the infections.

    • Principal Investigator
      AMAKO Kazunobu
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      細菌学
    • Research Institution
      Kyushu University

All 2006 2005 2004 2003 2002 2001

All Journal Article

  • [Journal Article] Assignment of the outer-membrane-subunit-selective domain of the membrane fusion protein in the tripartite xenobiotic efflux pump of Pseudomonas aeruginosa2006

    • Author(s)
      Eda, S., Maseda, H., Yoshihara, E., Nakae T.
    • Journal Title

      FEMS Microbiol. Letts. 254

      Pages: 101-107

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Organic solvent-selective domain of the resistance-nodulation-division-type xenobiotic-antibiotic transporters of Pseudomonas aeruginosa2006

    • Author(s)
      Li, X., Eda, S., Nakae, T.
    • Journal Title

      Microbiol. Immunol. 50

      Pages: 53-56

    • NAID

      10016919733

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Multidrug transporter MexB of Pseudomonas aeruginosa : overexpression, purification, and initial structural characterization 20062005

    • Author(s)
      Mokhonov, v., Mokhonova, E., Yoshihara,....Akama, H., Nakae, T.
    • Journal Title

      Protein Expression and Purification 40

      Pages: 91-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Forceful large-scale expression of "problematicmembrane proteins2005

    • Author(s)
      Mokhonova, E., Mokhonov, V.Akama, H., Nakae, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 327

      Pages: 650-665

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Preliminary crystallographic analysis of the antibiotic discharge outer membrane lipoprotein OprM of Pseudomonas aeruginosa with an exceptionally long unit cell and comlex lattice structure2005

    • Author(s)
      Akama, H., Kanemaki, M., Tsukihara, T., Nakagawa, A., Nakae, T.
    • Journal Title

      Acta Cryst. F61

      Pages: 131-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Crystal structure of the drug-discharge outer membrane protein, OprM, of Pseudomonas aeruginosa : Dual modes of membrane anchoring and occluded cavity end2004

    • Author(s)
      Akama, H., Kanemaki, M., Yoshimura, M., Tsukihara, Nakae, T.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 52816-52819

    • NAID

      120006770859

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] A quorum-sensing autoinducer enhances the mexAB-OprM efflux-pump expression without the MexR-mediated rgulation in Pseudomonas aeruginosa2004

    • Author(s)
      Sawada, I., Maseda, H., Nakae, T., Uchiyama, H., Nomura, N.
    • Journal Title

      Microbiol. Immunol. 48

      Pages: 435-439

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Role of the membrane fusion protien in the assembly of resistance-nodulation-cell divison multidrug efflux pump in Pseudomonas aeruginosa2004

    • Author(s)
      Mokhonov, V.V., Mokhonova, E.I., Akama, H., Nakaee, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 322

      Pages: 483-489

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Crystal structure of membrane fusion protein, MexA of the multidrug transporter in Pseudomonas aeruginosa2004

    • Author(s)
      Akama, H., Matsuura, T., Kashiwagi, S., Tsukihara, T., Nakae, T.
    • Journal Title

      J. biol. Chem. 279

      Pages: 25939-25942

    • NAID

      120006770857

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Crystal structure and function of MexAB-OprM antibiotic efflux pump subunits of Pseudomonas aeruginosa2004

    • Author(s)
      Nakae, T.
    • Journal Title

      Spring-8 Research Frontiers, Structural Biology

      Pages: 12-13

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] MexZ-mediated regulation of mexXY multidrug efflux pumpexpression in Pseudomonas aeruginosa by binding on the mexZ-MexX intergenic DNA2004

    • Author(s)
      Matsuo, Y., Eda, S., Gotoh, N., Yoshihara, E., Nakae, T.
    • Journal Title

      FEMS Microbiol. Lett. 238

      Pages: 23-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Salt-inducible multidrug efflux pump protein in the moderately halophilic bacterium Chromohalobacter sp.2004

    • Author(s)
      Tokunaga, H., Mitsuo, K., Ichinose, S., Nakae, T., Tokunaga, M.
    • Journal Title

      Appl. Env. Microbiol. 70

      Pages: 4424-4431

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Crystal structure of the membrane fusion protein, MexA, of bacterial antibiotic-xenobiotic exporter2004

    • Author(s)
      Nakae, T.
    • Journal Title

      Photon Factory Activity Report 22

      Pages: 42-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Enhancement of the mexAB-oprM efflux-pump expression by a quorum-sensing autoinducer and its cancellation by a regulator, MexT, of the mexEF-oprN efflux-pump operon in Pseudomonas aeruginosa 20052004

    • Author(s)
      Maseda, H., Nakae, T., Nomura, N
    • Journal Title

      Antimicrob. Agents Chemother. 48

      Pages: 1320-1328

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Crystal structure of the membrane fusion protein, MexA, of bacterial antibiotic-xenobiotic exporter2004

    • Author(s)
      Nakae, T., Akama, H., Matsuura, T., Tsukihara, T., Nakagawa, A.
    • Journal Title

      Photon Factory Activity Report. 22

      Pages: 42-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Linkage of the efflux-pump expression level with substrate extrusion rate in the MexAB-OprM efflux pump of Pseudomonas aeruginosa2003

    • Author(s)
      Narita, S., Eda, S., Yoshihara, E., Nakae, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 308

      Pages: 922-926

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space2003

    • Author(s)
      Eda, S., Maseda, H., Nakae, T.
    • Journal Title

      J. Biol. Chem. 278

      Pages: 2085-2088

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Mutations affecting DNA-binding activity of the MexR repressor of mexR-mexA-mexB-oprM operon expression 20042003

    • Author(s)
      Saito, K., Akama, H., Yoshihara, E., Nakae, T.
    • Journal Title

      J. Bacterio1. 183

      Pages: 6195-6198

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Function of the MexB efflux-transporter divided into two halves2003

    • Author(s)
      Eda, S., Yoneyama, H., Nakae, T.
    • Journal Title

      Biochemistry 42

      Pages: 7238-7244

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Topological localization of the subunit protiens of the three component RND-efflux pump MexAB-OprM in Pseudomonas aeruginosa2002

    • Author(s)
      Nakae, T., Guan, L., Yoneyama, H., Germ, M., Nakajima, A.
    • Journal Title

      Progress in Biomedical Optics and Imaging 3

      Pages: 106-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] high-level fluoroquinolone resistance in Pseudomonas aeruginosa due to interplay of the MexAB-OprM efflux pump and the DNA gyrase mutation2002

    • Author(s)
      Nakajima, A., Sugimoto, Y., Yoneyama, H., Nakae, T.
    • Journal Title

      Microbiol. Immuno1. 46

      Pages: 391-395

    • NAID

      50000571050

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Topological localization of the subunit protiens of the three component RND-efflux pump MexAB-OprM in Pseudomonas aeruginosa Progress in Biomedical Optics and Imaging2002

    • Author(s)
      Nakae, T.
    • Journal Title

      Progress in Biomedical Optics and Imaging 3

      Pages: 106-117

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Secondary-site mutation restores the transport defect caused by the transmembrane domain mutation of the xenobiotic transporter MexB in Pseudomonas aeruginosa Biochem. Biophys.2002

    • Author(s)
      Yoneyama, H., Maseda, H., Yamabayashi, T., Izumi, S., Nakae, T.
    • Journal Title

      Res. Commun. 292

      Pages: 513-518

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa2002

    • Author(s)
      Maseda, H., Kitao, M., Eda, S., Yoshihara, E, Nakae, T.
    • Journal Title

      Molec. Microbiol. 46

      Pages: 677-686

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Molecular mechanism of MexR-mediated regulation of MexAB-OprM efflux expression in Pseudomonas aeruginosa 20022001

    • Author(s)
      Saito, K., Eda, S., Maseda, H., Nakae, T.
    • Journal Title

      FEMS Microbiology Letters 195

      Pages: 23-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Evidence for coupling of membrane targeting and fuction of thesignal recognition particle (SRP) receptor FtsY2001

    • Author(s)
      Herskovits, A.A., Seluanov, A., Rajsbaum, R., tenHagen-Jongman, C.M., Henrichs, T., Bochkareva, E.S., Philips, G.J., Probst, F.J., Nakae, T., Ehrmann, M., Luirink, J., Bibi, E.
    • Journal Title

      EMBO reports 2

      Pages: 1040-1046

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • [Journal Article] Identification of essential charged residues in Transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa2001

    • Author(s)
      Guan, L., Nakae, T.
    • Journal Title

      J. Bacterio1. 183

      Pages: 1734-1739

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13142209
  • 1.  YOSHIHARA Eisaku (70167063)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 6 results
  • 2.  YONEYAMA Hiroshi (10220774)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  ISHII Junko (20212813)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  NARITA Shin-ichiro (30338751)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  AMAKO Kazunobu (20078752)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KAWATA Tomio (60035368)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KATO Keijiro (50028718)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KOBAYASHI Yoriko
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  HIRAMATSU Keiichi (10173262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  GOTOH Naomasa (30121560)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAMAGUCHI Akihito (60114336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  INOUE Matsuhisa (10008336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  IYOBE Shizuko (90008318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TANI Ayako (70284867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TAKADA Haruhiko (30135743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KANEMASA Yasuhiro (80330059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YANO Ikuya (60047008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KANEMASA Yasuhiro (80033059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  河野 恵 (10057292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  三輪谷 俊夫 (60029759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  横田 健 (10052953)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SATAKE Sachiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  GABRIEL Rumm
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TILMAN Schir
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  JURG P Rosen
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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