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MIYATA Naoki  宮田 直樹

ORCIDConnect your ORCID iD *help
Researcher Number 50114674
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015: 名古屋市立大学, 大学院薬学研究科, 特任教授
2015: 名古屋市立大学, 大学院薬学研究科薬化学分野, 教授
2012 – 2014: 名古屋市立大学, 薬学研究科(研究院), 教授
2007 – 2012: 名古屋市立大学, 大学院・薬学研究科, 教授
2006: 名古屋市立大学, 大学院薬学研究科, 教授 … More
2002 – 2005: 名古屋市立大学, 大学院・薬学研究科, 教授
1997 – 2001: 国立医薬品食品衛生研究所, 有機化学部, 部長
1992 – 1996: 国立衛生試験所, 有機化学部, 部長 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / 医薬分子機能学 / 化学系薬学 / 環境影響評価(含放射線生物学) / Chemical pharmacy
Except Principal Investigator
医薬分子機能学 / Drug development chemistry / Tumor therapeutics
Keywords
Principal Investigator
フラーレン / エピジェネティクス / ヒストン脱アセチル化酵素阻害薬 / 制がん剤 / クロノクーロメトリー / 活性酸素 / セミキノンアニオンラジカル / ニトロアレーンアニオンラジカル / スーパーオキシド / 電気化学 … More / 一電子還元 / 電子移動 / 化学計算 / 環境化学物質 / ニトロアレーン / 薬物代謝酵素 / 分子間相互作用 / 毒性評価 / 分子軌道計算 / DPV法 / リガンド / レセプター / 相互作用 / 酸化還元電位 / CV法 / DNA / 酵素 / 遺伝子発現制御 / 創薬分子設計 / ヒストン脱メチル化酵素阻害剤 / ヒストン脱アセチル化酵素阻害剤 / チューブリン / ヒストン脱アセチル化酵素 / ケミカルバイオロジー / 細胞内局在性 / 光解除性保護基 / 分子標的治療薬 / 蛍光検出 / エピジェネティクス / ケージド化合物 / 一酸化窒素 / N-ニトロソ化合物 / ニトロソ尿素 / ニトロソアミド / Greiss法 / 殺細胞効果 / ニトロソ化合物 / ニトロソウレア / グリース反応 / ニトロシル錯体 / 細胞毒性 / NO / Nitric Oxide / N-nitroso compound / NO-donor / N-nitroso urea / Cytotoxicity / Griess-Salzman method / オキシルラジカル / ラジカル消去剤 / 活性酸素種 / ファーマコフォア / カテキン / エダラボン / トコフェロール / オキシラジカル / ESR / スピントラップ剤 / 神経毒性 / oxyl radical / radical scavenger / active oxygen species / pharmacophore / fullerene / catechin / edaravone / tocopherol … More
Except Principal Investigator
一酸化窒素 / 有機化学 / DNA切断活性 / 活性酸素 / ニトロソアミン / 薬学 / アミドオキシム / Nitric Oxide / Amidoxime / エンジイン / バーグマン環化反応 / トリガー / enediyne / Bergman reaction / trigger / DNA cleavage / ヒドロキシルラジカル / フラーレン / 一重項酸素 / 血管弛緩作用 / 分化促進 / 白色腐朽菌 / シトクロムP450 / エポキシド / 変異原性 / 胎仔細胞分化促進 / グルタチオン-S-トランスフェラーゼ / モルモット回腸 / 炭素クラスター / 生体内毒性 / C_<60> / P450化学モデル / C_<60>-epoxide / ポリビニルピロリドン / スーパーオキシド / 3-モルホリノシドノニミン / 酸化ストレス / パーオキシナイトライト / ドナー化合物 / 化学プローブ / 酵素反応 / 脳神経疾患 / タンパク質 / 生物活性物質 / 活性酸素種 / ストレス / 分析科学 / 細胞・組織 / 酸化還元 / ヒドロキシアルギニン / 平滑筋弛緩作用 / シアノトリアゼン / Hydroxy-L-arginine / Smooth muscular relaxation action / N-オキシド構造 / 抗腫瘍化合物 / phenazine / N-oxide / hydroxyl radical / cancer / DNA damage / ヒドロキシラジ / ニトロサミン / グルコースオキシダーゼ / Hydroxyl / Nitosamine / 光照射 / 分子標的治療 / 抗がん剤耐性 / ケミカルバイオロジー / ケージド化合物 / 光スイッチ Less
  • Research Projects

    (18 results)
  • Research Products

    (79 results)
  • Co-Researchers

    (35 People)
  •  Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A

    • Principal Investigator
      Tamio Mizukami
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      Nagahama Institute of Bio-Science and Technology
  •  Photocontrol of NO and H2S treatment as signaling molecules and biological applications

    • Principal Investigator
      Nakagawa Hidehiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Synthesis of HDAC inhibitors that locally develop their inhibition activity in cellsPrincipal Investigator

    • Principal Investigator
      MIYATA Naoki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Oxidative stress imaging in organelle by novel TEMPO derivatives

    • Principal Investigator
      NAKAGAWA Hidehiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Development of drug candidates that epigenetically regulate gene expressionPrincipal Investigator

    • Principal Investigator
      MIYATA Naoki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Oxidative degeneration of neurodegenerative disease-related protein and reactive nitrogen oxide stress

    • Principal Investigator
      NAKAGAWA Hidehiko
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagoya City University
  •  Development of novel oxyl-radical quenching pharmacophores as drug candidatesPrincipal Investigator

    • Principal Investigator
      MIYATA Naoki
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Nagoya City University
  •  MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE

    • Principal Investigator
      KURIHARA Masaaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      NATIONAL INSTITUTE OF HEALTH SCIENCES
  •  Studies of Phenazine di N-Oxides as a New Type of Hydroxy Radical Donor

    • Principal Investigator
      FUKUHARA Kiyoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      National Institute of Health Sciences
  •  Synthesis of NO generating compounds with hydroxyl releasing ability

    • Principal Investigator
      TANNO Masayuki, 末吉 祥子
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      National Institute of Health Sciences (NIHS)
  •  MOLECULAR DESIGN AND SYNTHESIS OF A NEW CLASS OF TRIGGERED ENEDIYNE

    • Principal Investigator
      KURIHARA Masaaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      NATIONAL INSTITUTE OF HEALTH SCIENCES
  •  DPV法を利用した簡便なリガンドーレセプター相互作用解析手法の開発Principal Investigator

    • Principal Investigator
      宮田 直樹
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Synthesis of NO-donors as Biotransformation Model Compounds

    • Principal Investigator
      SUEYOSHI Shoko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      National Institute of Health Sciences (NIHS)
  •  一酸化窒素とスーパーオキシドを同時に発生する化合物の合成と機能解析

    • Principal Investigator
      TANNO Masayuki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      国立衛生試験所
  •  化学計算による環境化学物質の毒性評価の新手法の開発Principal Investigator

    • Principal Investigator
      宮田 直樹
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      国立衛生試験所
  •  Synthesis and Characterization of Biologically Active NO-donorsPrincipal Investigator

    • Principal Investigator
      MIYATA Naoki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      National Institute of Health Sciences(NIHS)
  •  フラーレンの生体におよぼす影響

    • Principal Investigator
      広部 雅和 (広部 雅昭)
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  クロノクーロメトリー法を用いた活性酸素ラジカルの発生と消去反応の解析Principal Investigator

    • Principal Investigator
      宮田 直樹
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      化学系薬学
    • Research Institution
      国立衛生試験所

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 酸化ストレスの医学(吉川敏一監修, 内藤裕二, 豊国伸哉編, 診断と治療社, 東京)2008

    • Author(s)
      中川秀彦, 宮田直樹
    • Publisher
      フリーラジカルの測定法
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] Identification of novel SIRT2-selective inhibitors using a click chemistry approach2014

    • Author(s)
      109. Prima R. Tatum, Hideyuki Sawada, Yosuke Ota, Yukihiro Itoh, Peng Zhan, Naoya Ieda, Hidehiko Nakagawa, Naoki Miyata, Takayoshi Suzuki.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 1871-1874

    • DOI

      10.1016/j.bmcl.2014.03.026

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
  • [Journal Article] Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors2014

    • Author(s)
      Suzuki T, Muto N, Bando M, Itoh Y, Masaki A, Ri M, Ota Y, Nakagawa H, Iida S, Shirahige K, Miyata N.
    • Journal Title

      ChemMedChem

      Volume: 9 Pages: 657-664

    • DOI

      10.1002/cmdc.201300414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22221009, KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007, KAKENHI-PROJECT-25290065
  • [Journal Article] Small-molecular modulators of cancer-associated epigenetic mechanisms2013

    • Author(s)
      Yukihiro Itoh , Takayoshi Suzuki and Naoki Miyata
    • Journal Title

      Molecular Biosystems

      Volume: 9 Pages: 873-896

    • DOI

      10.1039/c3mb25410k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
  • [Journal Article] Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly2013

    • Author(s)
      98. Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto and Naoki Miyata.
    • Journal Title

      PloS ONE

      Volume: 8

    • DOI

      10.1371/journal.pone.0068669

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007
  • [Journal Article] Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.2012

    • Author(s)
      Takayoshi Suzuki, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, and Naoki Miyata.
    • Journal Title

      J Med Chem

      Volume: 55 Pages: 9562-75

    • DOI

      10.1021/jm300837y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10F00812, KAKENHI-PROJECT-22221009, KAKENHI-PROJECT-24659050, KAKENHI-PROJECT-24689007, KAKENHI-PROJECT-221S0001
  • [Journal Article] Novel bisbenzimide-nitroxides for nuclear redox imaging in living cells、Bioorg.2012

    • Author(s)
      池田麻美子、中川秀彦, 他2名
    • Journal Title

      Med. Chem. Lett.

      Volume: 22 Pages: 1949-1952

    • DOI

      10.1016/j.bmcl.2012.01.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J08121, KAKENHI-PROJECT-22590103
  • [Journal Article] Loss of deacetylase activity of Hdac6 affects emotional behavior in mice2012

    • Author(s)
      Masahide Fukada
    • Journal Title

      PLoS ONE

      Volume: 7

    • DOI

      10.1371/journal.pone.0030924

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034, KAKENHI-PROJECT-21500364, KAKENHI-PROJECT-22700408, KAKENHI-PROJECT-24591693, KAKENHI-PROJECT-24659050
  • [Journal Article] Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors2012

    • Author(s)
      Takayoshi Suzuki, Mohammed Naseer Ahmed Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, and Naoki Miyata
    • Journal Title

      J. Med. Chem.

      Volume: 55 Pages: 5760-5773

    • DOI

      10.1021/jm3002108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Journal Article] Lysine demethylases inhibitors2011

    • Author(s)
      Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      J. Med. Chem.

      Volume: 54 Pages: 8236-8250

    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry2010

    • Author(s)
      Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn, Naoki Miyata
    • Journal Title

      Angew. Chem. Int. Ed. Engl.

      Volume: 49 Pages: 6817-6820

    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors2010

    • Author(s)
      Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Katoh, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
    • Journal Title

      J.Med.Chem. 53

      Pages: 5629-5638

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells2010

    • Author(s)
      Mamiko Ikeda, Hidehiko Nakagawa, Shizuka Ban, Hiroki Tsumoto, Takayoshi Suzuki, and Naoki Miyata
    • Journal Title

      Free Radic. Biol. Med

      Volume: 49 Pages: 1792-1797

    • DOI

      10.1016/j.freeradbiomed.2010.09.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590103
  • [Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry2010

    • Author(s)
      Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M.G.Finn, Naoki Miyata
    • Journal Title

      Angew.Chem.Int.Ed.Engl. 49

      Pages: 6817-6820

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors2009

    • Author(s)
      Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 131 Pages: 17536-17537

    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors2009

    • Author(s)
      Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      J. Med. Chem.

      Volume: 52 Pages: 2909-2922

    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate2009

    • Author(s)
      Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 31 Pages: 6989-6996

    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate2009

    • Author(s)
      Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 6989-6996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors2009

    • Author(s)
      Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 17536-17537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors2009

    • Author(s)
      Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      J.Med.Chem. 52

      Pages: 2909-2922

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Journal Article] Photoactivatable HNO-releasing compounds using the retro-Diels-Alder reaction2008

    • Author(s)
      Yusuke Adachi, Hidehiko Nakagawa, Kazuya Matsuo, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Chem. Commun

      Pages: 5149-5151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane2007

    • Author(s)
      Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Bioorg. Med. Chem. Lett 17

      Pages: 1451-1454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] New Series of Antiprion Compounds : Pyrazolone Derivatives Have the Potent Activity of Inhibiting Protease-Resistant Prion Protein Accumulation2007

    • Author(s)
      Ayako Kimata, Hidehiko Nakagawa, Ryo Ohyama, Tomoko Fukuuchi, Shigeru Ohta, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      J. Med. Chem 50

      Pages: 5053-5056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] Novel mitochondria-localizing TEMPO derivative for measurement of cellular oxidative stress in mitochondria, Bioorg2007

    • Author(s)
      Shizuka Ban, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata
    • Journal Title

      Med. Chem. Lett 17

      Pages: 2055-2058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] Photoinduced Nitric Oxide Release from Nitrobenzene Derivatives2005

    • Author(s)
      Takayoshi Suzuki, Osamu Nagae, Yuka Kato, Hidehiko Nakagawa, Kiyoshi Fukuhara, Naoki Miyata
    • Journal Title

      J. Am. Chem. Soc 127

      Pages: 11720-11726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Journal Article] 2, 2, 6, 6-Tetramethylpiperidin-1-oxyl probes for evaluating oxidative stress on the cell membrane and mitochondria, Methods in Molecular Biology

    • Author(s)
      Hidehiko Nakagawa, Naoki Miyata
    • Journal Title

      477 : Advanced Protocols in Oxidative Stress I,(Edited by : D. Armstrong, Humana Press, New York, NY)(依頼)

      Pages: 99-112

    • Data Source
      KAKENHI-PROJECT-17590089
  • [Patent] 新規アミド化合物及びその用途2012

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学
    • Filing Date
      2012-02-23
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 新規アミド化合物及びその用途2012

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      公立大学法人名古屋市立大学
    • Industrial Property Number
      2012-037082
    • Filing Date
      2012-02-23
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 新規ヒドロキサム酸誘導体及びその用途2012

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 新規ヒドロキサム酸誘導体及びその用途2012

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      公立大学法人名古屋市立大学, 他
    • Industrial Property Number
      2012-038977
    • Filing Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2010-01-20
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Industrial Property Number
      2010-009834
    • Filing Date
      2010-01-20
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] HIV複製阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-08-06
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びJHDM阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-01-20
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 抗うつ薬及びその用途2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] HIV複製阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-08-06
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Industrial Property Number
      2010-011431
    • Filing Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤2010

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2010-01-21
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 抗うつ薬及びその用途2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] HIV複製阻害剤2010

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2010-08-06
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] LSD阻害剤2010

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Filing Date
      2010-06-11
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] 抗うつ薬及びその用途2010

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] LSD阻害剤2009

    • Inventor(s)
      宮田直樹、他
    • Industrial Property Rights Holder
      名古屋市立大学、他
    • Filing Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] LSD阻害剤2009

    • Inventor(s)
      宮田直樹, 他
    • Industrial Property Rights Holder
      名古屋市立大学, 他
    • Industrial Property Number
      2009-140553
    • Filing Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Patent] アシルニトロソ誘導体環化付加アントラセン誘導体及び光作動性HNO供与体2008

    • Inventor(s)
      宮田直樹、中川秀彦、松尾和哉、鈴木孝禎
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Number
      2008-284899
    • Filing Date
      2008-11-05
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Patent] アシルニトロソ誘導体環化付加アントラセン誘導体及び光作動性HNO供与体2008

    • Inventor(s)
      宮田直樹中川秀彦ほか
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Number
      2008-284899
    • Filing Date
      2008-11-05
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Presentation] HDAC8選択的阻害薬の創製研究2014

    • Author(s)
      太田庸介、伊藤幸裕、武藤伸輔、中川秀彦、宮田直樹、鈴木孝禎
    • Organizer
      第31回 メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] クリックケミストリーを用いたHDAC阻害薬の探索研究2013

    • Author(s)
      後藤仰、鈴木孝禎、伊藤幸裕、粕谷佑輝、太田庸介、中川秀彦、宮田直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] クリックケミストリーを用いたHDAC8選択的阻害薬の創製研究:リード化合物探索から構造最適化研究まで2013

    • Author(s)
      太田庸介、武藤伸輔、伊藤幸裕、中川秀彦、宮田直樹、鈴木孝禎
    • Organizer
      第63回日本薬学会近畿支部大会
    • Place of Presentation
      京田辺
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] HDAC3選択的阻害薬の創製と化学遺伝学的応用研究2013

    • Author(s)
      伊藤幸裕、粕谷侑輝、中川秀彦、水上民夫、宮田直樹、鈴木孝禎
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] 新規SIRT2選択的阻害薬の創製 ~Structure-based Drug DesignによるSIR2013

    • Author(s)
      澤田英之、鈴木孝禎、今井英里佳、Mohammed Naseer Ahmed KHAN、中川秀彦、宮田直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] Click chemistryによるHDAC阻害薬ライブラリーの構築とアイソザイム選択的阻害薬の同定2013

    • Author(s)
      伊藤幸裕、太田庸介、粕谷侑輝、中川秀彦、宮田直樹、鈴木孝禎
    • Organizer
      第11回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] クリックケミストリーを用いたHDAC3 選択的阻害薬の迅速探索2012

    • Author(s)
      後藤仰,鈴木孝禎,粕谷侑輝,中川秀彦2,宮田直樹
    • Organizer
      第30回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] クリックケミストリーを用いたHDAC阻害薬用トリアゾール化合物ライブラリーの構築2012

    • Author(s)
      後藤仰, 鈴木孝禎, 粕谷 侑輝, 中川秀彦, 宮田直樹
    • Organizer
      第42回複素環化学討論会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] 新規SIRT2選択的阻害薬の創製2012

    • Author(s)
      澤田英之, 鈴木孝禎, 今井英里佳, Mohammed Naseer Ahmed Khan, 中川秀彦, 宮田直樹
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] Discovery of isozyme-selective histone deacetylase inhibitors by click chemistry2012

    • Author(s)
      Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
    • Organizer
      ACS National Meetng, Sprong 2012
    • Place of Presentation
      San Diego
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾酵素を阻害する化合物の創製を例にして2011

    • Author(s)
      宮田直樹
    • Organizer
      創薬懇話会2011 in岡山
    • Place of Presentation
      岡山(招待講演)
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] Design, Synthesis, and Biological Activity of cyclopropylamine-based LSD1 inhibitor2011

    • Author(s)
      Daisuke Ogasawara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾を阻害する化合物の創生を例にして2011

    • Author(s)
      宮田直樹
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010

    • Author(s)
      宮田直樹
    • Organizer
      第38回構造活性相関シンポジウム
    • Place of Presentation
      徳島大学(徳島)招待講演
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry2010

    • Author(s)
      Y. Kasuya, N. Miyata, et. al.
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, USA
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry2010

    • Author(s)
      Y. Kasuya, 宮田直樹, et.al.
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, USA.
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010

    • Author(s)
      宮田直樹
    • Organizer
      第38回構造活性相関シンポジウム
    • Place of Presentation
      徳島大学(徳島)(招待講演)
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] Discovery of selective inhibitors of lysine specific demethylase-12010

    • Author(s)
      T.Suzuki, 宮田直樹, et.al.
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, USA.
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成2010

    • Author(s)
      宮田直樹
    • Organizer
      第38回構造活性相関シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] Discovery of selective inhibitors of lysine specific demethylase-12010

    • Author(s)
      T. Suzuki, H. Nakagawa, N. Miyata, et. al.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, USA
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009

    • Author(s)
      宮田直樹, 他
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸(兵庫)
    • Year and Date
      2009-05-19
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009

    • Author(s)
      宮田直樹、他
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-05-19
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009

    • Author(s)
      宮田直樹
    • Organizer
      第2回Cancer Research Seminar
    • Place of Presentation
      名古屋市立大学(愛知)
    • Year and Date
      2009-11-18
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] HDAC6非感受性障害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明2009

    • Author(s)
      宮田直樹
    • Organizer
      日本ケミカルバイオロジー学会 第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-19
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009

    • Author(s)
      宮田直樹
    • Organizer
      第2回Cancer Research Seminar
    • Place of Presentation
      愛知
    • Year and Date
      2009-11-18
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] エピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして2009

    • Author(s)
      宮田直樹
    • Organizer
      第2回 Cancer Research Seminar
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-18
    • Data Source
      KAKENHI-PROJECT-20390034
  • [Presentation] ニトロベンゼン構造に基づく新規光誘起型NOドナーの開発2006

    • Author(s)
      中川秀彦, 鈴木孝禎, 加藤友香, 長江修, 福原潔, 宮田直樹
    • Organizer
      日本ケミカルバイオロジー研究会第1回年会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-08
    • Data Source
      KAKENHI-PROJECT-17590089
  • [Presentation] 7-Diethylaminocoumarin型光解除性保護基を導入したケージドHDAC阻害剤の合成と機能評価

    • Author(s)
      山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] 新規HDAC8選択的阻害薬の開発と生物活性評価

    • Author(s)
      3. 太田庸介、伊藤幸裕、武藤伸輔、中川秀彦、宮田直樹、鈴木孝禎
    • Organizer
      日本薬学会 第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] Development of a caged HDAC inhibitor with 7-diethylaminocoumarin-type photolabile protecting group

    • Author(s)
      Sota Yamada, Naoya Ieda, Mitsuyasu Kawaguchi, Naoki Miyata, Hidehiko Nakagawa
    • Organizer
      ICBS2014
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-11-17 – 2014-11-19
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] クマリン構造を有する光で活性制御可能な HDAC 阻害剤の開発

    • Author(s)
      山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24659050
  • [Presentation] 7-Diethylaminocoumarin型光解除性保護基を用いたケージドHDAC阻害剤の開発

    • Author(s)
      山田創太、家田直弥、川口充康、宮田直樹、中川秀彦
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-04 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-24659050
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    # of Collaborated Projects: 6 results
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  • 2.  NAKAGAWA Hidehiko (80281674)
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    # of Collaborated Products: 41 results
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  • 21.  YAMADA Souta
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  • 22.  ITOH Takehiko
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    # of Collaborated Products: 2 results
  • 23.  ITO Hidemi
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    # of Collaborated Products: 1 results
  • 24.  SUZUKI Hiromu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  KAWAGUCHI Yoshiharu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  FUKADA Masahide
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  TATUM Prima
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  TATUM PrimaRoechelle
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  白髭 克彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  鈴木 登
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  鈴木 貞夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  鈴木 操
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  池田 麻美子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  中山 敦雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  坂東 優篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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