SASAKI Takahisa 佐々木崇寿

Researcher Number	50129839
External Links
Affiliation (based on the past Project Information) *help	2001 – 2005: Showa University, School of Dentistry, Professor, 歯学部, 教授 2001: Department of Oral Histology, School of Dentistry, Showa University, 医学部, 教授 1998 – 1999: 昭和大学, 歯学部, 教授 1989 – 1997: 昭和大学, 歯学部, 助教授
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Morphological basic dentistry Except Principal Investigator Functional basic dentistry / 補綴理工系歯学 / Morphological basic dentistry
Keywords	Principal Investigator in vivo / in vitro / 破骨細胞 / 電子顕微鏡 / 骨吸収 / 骨粗鬆症 / H-ATPase / OPG / RANKL / Bafilomycin A1 … More / Electron microscopy / 免疫組織化学 / oc / Osteoclast / 細胞培養 / E-64 / bone metabolomics / pathology / oral histology / cell・tissue / gene / 歯周病 / OPG遺伝子欠損マウス / オステオプロテゲリン / 骨代謝学 / 病理学 / 歯学 / 細胞・組織 / 遺伝子 / osteoporosis / osteoclast / cathepsin K / カテプシンK / Bone remodelling / Bone resorption / Bisphosphonate / HィイD1+ィエD1-ATPase inhibitor / Ruffled border / 歯科矯正 / H^+-ATPase / ビスホスフォネート / バフィロマイシンA1 / H^+-ATPase阻害剤 / 波上縁 / 骨改造 / bisphosphonate / 液胞型H^+-ATPase阻害剤 / 波状縁 / Immunohistochemistry / X-ray Microanalysis / Dentine / Tooth Enamel / Bone Tissues / oc mice / Osteosclerosis / 組織学 / 骨発生 / 大理石病 / エナメル質 / 微小部x線分析 / 象牙質 / エネメル質 / 骨組織 / ocマウス / 大理石骨病 / Ultrastructure / Cathepsin / RGD peptide / Integrin / 微細構造 / カテプシン / RGDペプチド / インテグリン … More Except Principal Investigator 破骨細胞 / 骨芽細胞 / Smad / osteoclast / 骨吸収 / M-CSF / Osteoblast / カルシトニン / 波状縁 / p60^<c-src> / BMP / osteoblast / Osteoclast / MーCSF / RANKL / リポ多糖 / マクロファージ / bisphosphonates / ビスフォスフォネート / calcitonin / 吸収窩 / ポドソーム形成 / ポドソーム / 明帯 / c-src / ocマウス / oc / opマウス / op / 活性型ビタミンD / 骨誘導因子 / 骨髄由来ストロ-マ細胞 / 骨吸収調節因子 / 大理石骨病 / マクロファ-ジコロニ-刺激因子 / ectonic bone formation / soluble RANKL / Coupling / Bisphosphonate / Receptor activator of NF-κB (RANKL) / Osteoprotegerin (OPG) / サイトカイン / 骨代謝共役因子 / アルカリフォスファターゼ / オステオプロテゲリン / 骨髄間質細胞 / 異所性骨形成 / 可溶性RANKL / 骨代謝共役 / ビスフォスホネート / OPG / surface treatment / electric discharged machining / titanium / 表面改質 / 放電加工 / チタン / ERK / Lipopolysaccharide / p38 MAP kinase / Inflammatory cytokine / Macrophage / Osteoclasts / p38MAPキナーゼ / 炎症性サイトカイン / NF-kB / signal transduction / bone resorbing factors / bone morphogenetic protein / myoblast / ビスホスフォネート / 骨形成 / BMPレセプター / p130^<Cas> / NF-κB / シグナル伝達 / 筋芽細胞 / pit formation / osteoclast function / osteoclast formation / screening system / bone resorption / 破骨細胞前駆細胞 / 骨吸収評価系 / 骨吸収試験 / アクチンリング形成 / チロシンフォスファーゼ / ビイフォスフォネート / cAMP / アクチンリング / 破骨細胞機能評価系 / 破骨細胞形成評価系 / スクリーニング系 / small GTP binding protein rho / PI-3 kinase / podosme / clear zone / ruffled border / Focal adhesion kinase / Pl-3キナーゼ / 低分子量G蛋白rho / PI-3キナーゼ / 1alpha,25(OH)_2D_3 / macrophage colony stimulating (M-CSF) / osteopetrosis / マクロファ-ジコロニ-剌激因子 / Bone resorption / 1alpha, 25(OH)_2D_3 / Macrophage colony stimulating factor / Bone resorbing factors / マウス骨髄細胞培養 / 骨吸収因子 / retinoic acid / cell line / differentiation / 骨肉腫 / レチノイン酸 / 培養細胞 / 分化 / cell-cell interaction / osteopetosis / 1alpha, 25 (OH) _2D_3 / macrophage / monocyte / 1α,25(OH)_2D_3 / マクロファ-ジ / Early Calcification / Bone Morphogenetic Protein / Periosteum / Osteoblasts / Dental Implant / Synthetic Hydroxyapatite / Biomaterials / Bone Regeneration / 初期石灰化 / 骨誘導物質 / 骨膜 / 歯科インプラント / 合成水酸化アパタイト / 生体材料 / 骨再生 Less

Effects of osteoprotegerin administration on osteoclast differentiation and trabecular bone structure in osteoprotegerin-deficient mice.Principal Investigator
- Principal Investigator
  
  MAYAHARA Mitsuori, 佐々木崇寿
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Establishment of Bone Metabolism Research through Regulation of Osteoclast Differentiation and FunctionsPrincipal Investigator
- Principal Investigator
  
  SASAKI Takahisa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Study on mechanism of the coupling between bone resorption and bone formation
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Analysis of signal transduction of inflammatory cytokines in bone destruction
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  MATSUMOTO DENTAL UNIVERSITY
  Showa University
An assessment of biocompatibility on the surface treatment by wire type EDM method.
- Principal Investigator
  
  MIYAZAKI Takashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Showa University
Regulation of Osteoclast function by H-ATPase InhibitorPrincipal Investigator
- Principal Investigator
  
  SASAKI Takahisa
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
A Study of formation and Resorption of Bone and Teeth : An Investigation Using Osteosclerotic MicePrincipal Investigator
- Principal Investigator
  
  SASAKI Takahisa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Establishment of assay systems for examining bone metabolism : Studies on differentiation and function of osteoblasts and osteoclasts
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Localization and Functions of Integrins and Proteinase in OsteoclastsPrincipal Investigator
- Principal Investigator
  
  SASAKI Takahisa
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Analysis of signaling pathways involved in polarization of osteoclasts.
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Development of reliable screening systems for drugs which regulate bone resorption : In vitro assay systems for osteoclast formation and function.
- Principal Investigator
  
  SUDA Tatsuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Study on Interaction between Osteoclast Progenitors and Osteoblastic Cells in Osteoclast Development.
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Analysis of Jaw Bone Regeneration Processes in Young, Adult and Old Animals, in Vivo and in Vitro.
- Principal Investigator
  
  TAKESHITA Nobuyoshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Okayama University
Rolo of Osteoblastic Cells in Osteoclast Development.
- Principal Investigator
  
  TAKAHASHI Naoyuki
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Establishment of Assay System for Studying Osteoblastic Function and Differentiation Using Newly Isolated Osteoblast-Like Cell Lines
- Principal Investigator
  
  YOSHIKI Shusaku
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Establishment of the screening methods for bone-resorbing factors using in vitro osteoclast formation system.
- Principal Investigator
  
  SUDA Tatsuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University

All 2006 2005 2004 2003

All Journal Article Book

[Book] 組織学・口腔組織学2005
- Author(s)
  佐々木崇寿
- Total Pages
  369
- Publisher
  わかば出版
- Data Source
  KAKENHI-PROJECT-17591924
[Book] Biological Mechanisms of Tooth Movement and Craniofacial Adaptation.2004
- Author(s)
  Mayahara M, Kenmotsu S, Sasaki T
- Total Pages
  387
- Publisher
  Amarin Printing and Publishing Public Co.Ltd.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Book] Biological Mechanisms of Tooth Movement and Craniofacial Adaptation2004
- Author(s)
  Mayahara M, Kenmotsu S, Sasaki T
- Publisher
  Amarin Printing and Publishing Public Co.Ltd.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Effects of a specific cathepsin K inhibitor on the structure and resorptive function of osteoclasts.2006
- Author(s)
  Kenmotsu, S., Ochi, Y., Tanaka, M., Kishikawa, K., Sasaki, T.
- Journal Title
  
  O. S. Printing House Co., Ltd.
  
  Pages: 151-158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591924
[Journal Article] Differentiation of osteoclast and dendritic cells from common precursors : relationships between bone metabolism and immune system.2006
- Author(s)
  Takami, M., Mochizuki, A., Suzumoto, R., Sasaki, T.
- Journal Title
  
  O. S. Printing House Co., Ltd.
  
  Pages: 143-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591924
[Journal Article] Osteoprotegerin administration reduces trabecular bone loss and maintains internal bone structure in osteoprotegerin-deficient mice.2006
- Author(s)
  Yamazaki, H., Sasaki, T.
- Journal Title
  
  0. S. Printing House Co., Ltd.
  
  Pages: 207-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591924
[Journal Article] Effects of osteoprotegerin administration on osteoclast differentiation and trabecular bone structure in osteoprotegerin-deficient mice.2005
- Author(s)
  Yamazaki H, Sasaki T
- Journal Title
  
  J Electron Microsc. 54(5)
  
  Pages: 467-477
- NAID
  10017254343
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591924
[Journal Article] Differentiation and function of osteoclasts cultured on bone and cartilage.2005
- Author(s)
  Suzumoto R, Takami M, Sasaki T
- Journal Title
  
  J Electron Microsc. 54(6)
  
  Pages: 529-540
- NAID
  10017677198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591924
[Journal Article] Cellular mechanisms of inhibition of osteoclastic resorption of bone and calcified cartilage by long-term pamidronate administration in OVX mature rats.2003
- Author(s)
  Mayahara M, Sasaki T
- Journal Title
  
  Anatomical Record 274A
  
  Pages: 817-826
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Specific biological functions of vacuolar-typeH-ATPase and lysosomal cysteine proteinease cathepsin K in osteoclasts.2003
- Author(s)
  Sahara T, Itoh k, Debari k, Sasaki T
- Journal Title
  
  Anatomical Record 270A
  
  Pages: 152-161
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Involvement of H-ATPase in incroporation of rsedronate into osteoclasts.2003
- Author(s)
  Takami M, Sahara T, Sasaki T et al.
- Journal Title
  
  Bone 32
  
  Pages: 341-349
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Specific biological functions of vacuolar-typeH-ATPase and lysosomal cysteine proteinease, cathepsin K, in osteoclasts.2003
- Author(s)
  Sahara T, Itoh k, Debari k, Sasaki T
- Journal Title
  
  Anatomical Record 270A
  
  Pages: 152-161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Destruxins, cyclodepsipeptides, block the formation of actin rings and prominent clear zones and ruffled borders in osteoclasts.2003
- Author(s)
  Nakagawa H, Takami M, Udagawa N, Sawae Y, Suda K, Sasaki T et al.
- Journal Title
  
  Bone 33
  
  Pages: 443-455
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Osteoclast differentiation at growth plate cartilage -tabecular bone junction in newbone rat femur.2003
- Author(s)
  Sawae Y, Sahara T, Sasaki T
- Journal Title
  
  Journal of Electron Microscopy 52(6)
  
  Pages: 493-502
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Osteoclast differentiation and characteristic trabecular bone formation during growth plate destruction in osteoprotegerin-deficient mice.2003
- Author(s)
  Kawana F, Sasaki T
- Journal Title
  
  Journal of Electron Microscopy 52(6)
  
  Pages: 515-525
- NAID
  10011950833
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Specific biological functions of vacuolar-typeH-ATPase and lysosomal cysteine proteinease, cathepsin K, in osteoclasts.2003
- Author(s)
  Sahara T, Itoh k, Debari K, Sasaki T
- Journal Title
  
  Anatomical Record 270A
  
  Pages: 152-161
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591947
[Journal Article] Differentiation and functions of osteoclasts and odontoclasts in mineralized tissue resorption.2003
- Author(s)
  Sasaki T
- Journal Title
  
  Microscopy Research and Technique 61
  
  Pages: 483-495
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591947

1. TAKAHASHI Naoyuki (90119222)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. SUDA Tatsuo (90014034)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. UDAGAWA Nobuyuki (70245801)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. YAMAGUCHI Akira (00142430)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KATAGIRI Takenobu (80245802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MIZOGUCHI Toshihide (90329475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HIRAOKA Yukihiro (20097512)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MAYAHARA Mitsuori (30384184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKESHITA Nobuyoshi (00118275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KUBOKI Yoshinori (00014001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWASAKI Kenzo (50064374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HIRAI Goro (80013845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUJI Takanori (50201637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONO Toshiro (50185641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAGAI Noriyuki (90085770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TANAKA Hirofumi (30146899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIKI Shusaku (30085740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IKEDA Tohru (00211029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KAKUTA Saburou (40112726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKITO Jiro (00197237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KUROIWA Mie (90153395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TACHIKAWA Tetsuhiko (10085772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MIYAURA Chisato (20138382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MIYAZAKI Takashi (40175617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. LEE WonSik (40276605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHIBATA Yo (30327936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. TAKAMI Masamichi (80307058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
28. 伊藤雅波 (10349045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. 石浦美帆 (40327937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. WILLIAMS D. M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. RUCH J. V.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. DONATH K.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. FRANK R. M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. DAVIES J. E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. FERANHEAD R. W.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SASAKI Takahisa 佐々木 崇寿

Research Projects

Research Products

Co-Researchers

Effects of osteoprotegerin administration on osteoclast differentiation and trabecular bone structure in osteoprotegerin-deficient mice.Principal Investigator

Principal Investigator

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Establishment of Bone Metabolism Research through Regulation of Osteoclast Differentiation and FunctionsPrincipal Investigator

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Regulation of Osteoclast function by H-ATPase InhibitorPrincipal Investigator

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A Study of formation and Resorption of Bone and Teeth : An Investigation Using Osteosclerotic MicePrincipal Investigator

Principal Investigator

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Principal Investigator

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Localization and Functions of Integrins and Proteinase in OsteoclastsPrincipal Investigator

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SASAKI Takahisa 佐々木崇寿