KOMIYAMA Makoto 小宮山眞

… Alternative Names

小宮山真コミヤママコト

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Researcher Number	50133096
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Affiliation (based on the past Project Information) *help	2015 – 2017: 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMS招聘研究員 2013 – 2015: 筑波大学, 生命領域学際研究センター, 教授 2012: 筑波大学, 学内共同利用施設等, 教授 2011: 筑波大学, 生命領域学際研究センター, 教授 2007 – 2010: The University of Tokyo, 先端科学技術研究センター, 教授 … More 2006: 東大, 先端科学技術研究センター, 教授 2000 – 2005: Research Center for Advanced Science and Technology, the University of Tokyo, Professor, 先端科学技術研究センター, 教授 1995 – 2000: 東京大学, 大学院・工学系研究科, 教授 1997: 東京大学, 大学院・工学研究科, 教授 1991 – 1997: 東京大学, 工学部, 教授 1987 – 1990: 筑波大学, 物質工学系, 助教授 1986: 東京大学, 工学部, 助手 1986: 東大, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Science and Engineering / 有機工業化学 / Chemistry / Bio-related chemistry / Bioorganic chemistry / 広領域 / 有機工業化学 / 工業物理化学・複合材料 / 工業物理化学 / Chemistry related to living body … More Except Principal Investigator … More Science and Engineering / Synthetic chemistry / 高分子合成 / Bioorganic chemistry / 無機工業化学 Less
Keywords	Principal Investigator RNA / DNA / シクロデキストリン / 加水分解 / 核酸 / 遺伝子操作 / バイオテクノロジー / セリウム / ペプチド核酸 / 制限酵素 … More / リン酸ジエステル / リボザイム / 人工酵素 / 人工制限酵素 / Hydrolysis / ゲノム / オリゴアミン / 協同触媒作用 / 分子認識 / PNA / Peptide Nucleic Acid / Artificial Restriction Enzyme / アクリジン / 機能性核酸 / Cerium / アミン / Nucleic Acid / PDT / Phenol / Cyclodextrin / フェノール / 選択的合成 / 遺伝子 / 遺伝子組換え / 人工リボヌクレアーゼ / ランタニド / インターカレーター / 亜鉛錯体 / 第2メッセンジャ- / 環状リン酸 / リボ核酸 / 位置選択的開裂 / 分離剤 / オレフィン / 修飾シクロデキストリン / DNA損傷 / テロメア / DNAメチル化 / DNA結合タンパク質 / エピゲノム / ゲノム断片分離 / インベージョン / Acridine / Phosphodiester / リン酸エステル / Ribozvme / Proteins / Biopolvmer / Functional Nucleic Acid / 刺激応答性核酸 / DNA分子組織体 / DNA分組織体 / リボザイ / タンパク質 / 生体高分子 / Intercalator / Lanthanide / Artificial nuclease / Therapy / AIDS / Cancer / Artificial ribonuclease / Oligoamine / 治療 / エイズ / がん / Chloroform / Ethylene glycol / Intramolecular interaction / Scanning tunneling microscopy / 触媒 / 芳香族置換反応 / 走査型トンネル顕微鏡 / エチレングレコール / クロロホルム / エチレングリコール / 分子間相互作用 / トンネル顕微鏡 / Porphyrin / Chlorophll / Photosensitizer / PDT for Concer / レーザー / ヘマトポルフィリン / クロロフィル誘導体 / ポルフィリン誘導体 / 光増感剤 / 活性酸素 / 一重項酸素 / DNAの光切断 / 蛍光顕微鏡 / フェオフォーバイド / 光治療 / ポルフィリン / クロロフィル / 増感色素 / ガンの光治療 / Selective synthesis / Modified cyclodextrin / Formaldehyde / パラ選択性 / 分子複合体 / ホルムアルデヒド / バイテクノロジー / 相同組換え / ペプチド / 相同組替え / ゲノム編集 / 配位子 / 銅(I)イオン / 選択性 / 分子設計 / ヒドロキシメチルフェノール / 化学修飾 / シクロデキストリンポリマー / 修飾電極 / センサ / 分子識別 / 塩化銅(【I】) / 塩化銅(【II】) / 活性炭 / 吸脱着剤 / 一酸化炭素 / センサ材料 / 単分子膜 / 包接化合物形成 / 薄膜 / ランタノイド / ヌクレアーゼ / ランタニド金属 / コレステロール / インプリント / 水溶液 / 高分子 / ポリビニルジアミノトリアジン / 核酸塩基 / 水素結合 / 抗原抗体反応 / セリウムイオン / イムノアッセイ / アミノ酸 / 不斉認識 / 蛍光 / 希土類錯体 / 希土類イオン / RNA切断 / DNA切断 / オリゴヌクレオチド / セリウム(III)イオン / 第2メッセンジャー / アデノシン環状リン酸 / アルカリ金属塩 / 位置選択的加水分解 / 人工ホスホエステラ-ゼ / 細胞応答制御 / アデノシン3',5'ー環状リン酸 / コバルト(III)錯体 / 多元分子認識 / カラム分離 / ヒドロキシメチルフェノ-ル / イエホスホエステラ-ゼ / コバルト錯体 / 選択的分離 / アルカリ金属イオン / 銅(I)・アミン錯体 / エチレン分離 / 分子内触媒作用 / アミン・亜鉛(II)錯体 / リボ核酸開裂 … More Except Principal Investigator リポソーム / 光制御 / アゾベンゼン / バイオエレクトロニクス / エレクトロニクス素子 / 蛋白質の化学修飾 / 蛋白質工学 / 生体模倣技術 / モレキュラーインプリンティング / 生体機能分子 / エンドサイトーシス / RNAポリメラーゼ / 三重鎖 / 二重鎖 / 融解温度 / DNA / 核酸 / バーチャルエボルーション / 光応答型オリゴヌクレオチド / リソソーム / 高機能材料 / 材料化プロセス / イムノアッセイ / 人工制限酵素 / 触媒反応 / 有機合成 / 錯体合成 / 希土類錯体 / multinuclear complex / artificial hydras / artificial peptidase / amino acid / peptide / 多核金属錯体 / 人工加水分解酵素 / 人工ペプチダーゼ / アミノ酸 / ペプチド / immunoliposome / molecular recognizing protein / surfactant-enzyme complex / bio-targeting / artificial receptor / molecular imprinting / bacterial magnetic particle / molecular architecture / Synthesized sugar lipid / Surfactant / β-Cyclodextrin / lipospme / Lipid-tagged antibody / Protein A / Bacterial magnetic particles / Molecular archtecture / マイクロエマルション / モレキュラーインプリント / バイオセンシング / ドラッグデリバリー / ディスプレイ / 分子認識 / ターゲティング / バイオターゲティング分子 / 生体分子アーキテクチャー / 界面活性剤-酵素複合 / イムノリポソーム / 脂質修飾抗体結合タンパク質 / バイオターゲティング / 界面活性剤-酵素複合体 / 人工レセプター / モレキュラーインプリント法 / 分子アーキテクチャー / 合成糖脂質 / 界面活性剤 / シクロデキストリン / リン脂質修飾抗体 / プロテインA / 磁性細菌粒子 / 分子設計 / 水和 / アクリルアミド / アクリロニトリル / 金属銅超微粒子 / 金属銅コロイド / プロモーター / 転写反応 / RNAポロメラーゼ / スピロピラン / マンネンタケのα-1,3-グルカン / Ce(IV)イオン・糖錯体のDNA切断 / シスプラチン-デキストラン錯体 / 水溶性キトサンハイブリッド / 生理活性 / カルボキシル化キチン / 硫酸化糖 / α-1,3-グルカンの抗腫瘍活性 / DNAオリゴマーの切断 / グルカミン複合体 / Ce(IV) / アセチルガラクトサミン / PEG-キトサンハイブリッド / 燐酸化キチン / カードラン硫酸 / リン酸キチン / サクシノグリカン / NMR / 活性酸素 / DNAの切断 / 高分子医薬 / キチン・キトサン / 抗エイズウイルス活性 / 細胞内親和部位 / DNAオリゴマー / ホスホロチオエ-ト型DNA / フルオレセイン / 蛍光色素修飾 / インターフェイス / オリゴヌクレオチド / 蛍光修飾 / フロロジェニック / フルオレセインサ / 高可能材料 / イノムアッセイ / αーターチエニル / 光駆動型薬剤 / 修飾ヌクレオチド / マグネシウムイオン / 人工酵素 / 高次構造特異的切断 / 錯体成定数 / 高次構造 / 大環状シッフ塩基配位子 / ランタニド錯体 / tRNA Less

Creation of new genome science using chemical tools to precisely detect modification and damage of human genomePrincipal Investigator
- Principal Investigator
  
  Komiyama Makoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bio-related chemistry
- Research Institution
  National Institute for Materials Science
Creation of genome manipulation technology using super restriction enzymePrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  University of Tsukuba
  The University of Tokyo
Gene Manipulation of Huge DNA by Super Artificial Restriction EnzymePrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto, 小宮山真
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  The University of Tokyo
AFMによる1分子DNA/金電極系デバイスの電気伝導度測定Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
人工DNAカッターを用いた巨大DNAのマニピュレーションPrincipal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The University of Tokyo
化学修飾DNAを用いた遺伝子発現の光制御
- Principal Investigator
  
  浅沼浩之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
光応答性DNAによる酵素反応の光制御
- Principal Investigator
  
  浅沼浩之
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
New Chemical Approaches for Functional of DNA/RNAPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Artificial Restriction Enzymes for Future Nucleic Acids ChemistryPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
化学修飾DNAを用いた遺伝子発現の光制御
- Principal Investigator
  
  浅沼浩之
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
複数金属イオンを用いたRNA加水分解触媒の構築とリボザイムの作用機構の解明Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
複数金属イオンを用いたRNA加水分解触媒構築とリボザイムの作用機構の解明Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Preparation of Artificial nuclease and creation of new-biotechnologyPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Bioorganic chemistry
- Research Institution
  the University of Tokyo
複数金属イオンを用いたRNA加水分解触媒の構築とリボザイムの作用機構の解明Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Study on molecular architecture and its application
- Principal Investigator
  
  MATSUNAGA Tadashi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Agriculture and Technology
Selective Chemical Manipulation of Peptides by Metal Complex Catalysts
- Principal Investigator
  
  YASHIRO Morio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  The University of Tokyo
水溶液中で水素結合を形成し、基質を分子認識するハイブリッドポリマーの構築Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
糖鎖による生命分子制御
- Principal Investigator
  
  瓜生敏之
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Teikyo University of Science & Technology
  The University of Tokyo
複数金属イオンを用いたRNA加水分解触媒の構築とリボザイムの作用機構の解明Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
生体物質と希土類錯体のかかわりPrincipal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
修飾ヌクレオチドによる生体環境場における情報伝達系の光制御
- Principal Investigator
  
  佐々木政子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
Scanning Tunneling Microscopy on Complex Formation of Cyclodextrins and on Their Catalytic Mechanism for Selective Organic SynthesisPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  Graduate School of Engineering, The University of Tokyo
Preparation of Artificial Ribonucleases and Their Applications to the Therapy for Cancer and AIDSPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  Graduate School of Engineering, The University of Tokyo
修飾ヌクレオチドによる生体環境場における情報伝達系の光制御
- Principal Investigator
  
  佐々木政子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
修飾ヌクレオチドによる生体環境場における情報伝達系の光制御
- Principal Investigator
  
  佐々木政子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
希土類錯体の新展開
- Principal Investigator
  
  足立吟也
- Project Period (FY)
  1994 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
オリゴアミン・オリゴヌクレオチド系ハイブリッドによる核酸の塩基配列特異的加水分解Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
RNAを高次構造特異的に切断する人工酵素の分子設計
- Principal Investigator
  
  YASHIRO Morio
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
希土類錯体の新展開
- Principal Investigator
  
  足立吟也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  無機工業化学
- Research Institution
  Osaka University
生体機能分子の設計・合成
- Principal Investigator
  
  軽部征夫
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  The University of Tokyo
生体機能分子の設計・合成
- Principal Investigator
  
  輕部征夫
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  The University of Tokyo
生体機能分子の設計・合成
- Principal Investigator
  
  輕部征夫
- Project Period (FY)
  1993 – 1997
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  The University of Tokyo
第2メッセンジャー(アデノシン環状リン酸)の生成と開裂を制御する人工材料の開発Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
オリゴアミン・オリゴヌクレオチド系ハイブリッドによる核酸の塩基配列特異的加水分解Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
DEVELOPMENT OF MODIFIED CYCLODEXTRINS FOR SELECTIVE ORGANIC SYNTHESISPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tokyo
Study of Photosensitizers for Effective Photodynamic Theraphy of CancerPrincipal Investigator
- Principal Investigator
  
  KOMIYAMA Makoto
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  工業物理化学・複合材料
- Research Institution
  The University of Tokyo
人工酵素を用いる高選択的分離Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
第2メッセンジャ-(アデノシン環状リン酸)の生成と開裂を制御する人工材料の開発Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
シクロデキストリン複合体の構造制御による高選択的分子認識材料の構築Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
人工酵素を用いる高選択的分離Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
第2メッセンジャ-(アデノシン環状リン酸)の生成と開裂を制御する人工材料の開発Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
シクロデキストリン複合体の構造制御による高選択的分子認識材料の構築Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
修飾シクロデキストリンを用いる人工制限酵素の構築Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  有機工業化学
- Research Institution
  University of Tsukuba
省エネルギ-型高選択的オレフィン分離剤の開発Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
シクロデキストリン複合体の構造制御による高選択的分子認識材料の構築Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
高選択的合成触媒能を有する修飾シクロデキストリンの分子設計Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  工業物理化学
- Research Institution
  University of Tsukuba
省エネルギー型高選択的オレフィン分離剤の開発Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
高選択的な分子識別能を有する固定化シクロデキストリン単分子膜の合成Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  University of Tsukuba
高選択的な分子識別能を有する固定化シクロデキストリン単分子膜の合成Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
活性炭・銅塩系一酸化炭素吸着剤における吸着活性種Principal Investigator
- Principal Investigator
  
  小宮山真
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  有機工業化学
- Research Institution
  The University of Tokyo
高分子支持銅コロイドによるニトリル類の選択的水和反応
- Principal Investigator
  
  平井英史
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  高分子合成
- Research Institution
  The University of Tokyo

[Book] "Covalent and non-covalent conjugates of oligonucleotide as artificial restriction DNA cutters" In Keith R Fox (Eds.) "DNA Conjugates and Sensors"2012
- Author(s)
  Makoto Komiyama
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-22000007
[Book] 「人工酵素の歴史と将来」「酵素利用技術体系(小宮山眞監修)」2010
- Author(s)
  小宮山眞
- Publisher
  NTS
- Data Source
  KAKENHI-PROJECT-22000007
[Book] 酵素利用技術体系(「スーバー人工制限酵素」第4編第5章第5節)(小宮山眞編)2010
- Author(s)
  小宮山眞、須磨岡淳
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-18001001
[Book] 超分子サインエス&テクノロジー(「人工ヌクレアーゼ」第4章第2節)(国武豊喜編)2009
- Author(s)
  小宮山眞、堅田仁、宮島佳孝
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-18001001
[Book] 超分子サイエンス&テクノロジー(国武豊喜編, 人工ヌクレアーゼ)2009
- Author(s)
  小宮山眞, 他
- Total Pages
  9
- Data Source
  KAKENHI-PROJECT-18001001
[Book] 希土類の材料技術、5部第38章第1 節、「希土類イオンによるRNA、DNAの切断」2008
- Author(s)
  葛谷明紀、小宮山眞
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-18001001
[Book] 生物有機化学2004
- Author(s)
  小宮山真
- Total Pages
  146
- Publisher
  裳華房
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Book] 超分子サイエンス、4章2節、「人工ヌクレアーゼ」
- Author(s)
  堅田仁、宮島佳孝、小宮山眞
- Publisher
  エヌ・ティー・エス(印刷中)
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Inhibition of nonenzymatic depurination of nucleic acids by polycations2017
- Author(s)
  Ran An, Ping Dong, Makoto Komiyama, Pan, Xiaoming, Xingguo Liang
- Journal Title
  
  FEBS OPEN BIO
  
  Volume: 7 Issue: 11 Pages: 1707-1714
- DOI
  10.1002/2211-5463.12308
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Applications of PNA-Based Artificial Restriction DNA Cutters2017
- Author(s)
  Narumi Shigi, Jun Sumaoka, Makoto Komiyama
- Journal Title
  
  MOLECULES
  
  Volume: 22 Issue: 10 Pages: 1586-1586
- DOI
  10.3390/molecules22101586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Allosteric control of nanomechanical DNA origami pinching devices for enhanced target binding2017
- Author(s)
  Akinori Kuzuya, Yusuke Sakai, Takahiro Yamazaki, Yan Xu, Yusei Yamanaka, Yuichi Ohya and Makoto Komiyama
- Journal Title
  
  Chemical Communications
  
  Volume: 53 Issue: 59 Pages: 8276-8279
- DOI
  10.1039/c7cc03991c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26288083, KAKENHI-PROJECT-15H02189, KAKENHI-PROJECT-17H03091
[Journal Article] Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics2017
- Author(s)
  Makoto Komiyama, Keitaro Yoshimoto, Masahiko Sisido, Katsuhiko Ariga
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 90 Issue: 9 Pages: 967-1004
- DOI
  10.1246/bcsj.20170156
- NAID
  130006077919
- ISSN
  0009-2673, 1348-0634
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Suppression of Myogenic Differentiation of Mammalian Cells Caused by Fluidity of a Liquid-Liquid Interface2017
- Author(s)
  Kosuke Minami, Taizo Mori, Waka Nakanishi, Narumi Shigi, Jun Nakanishi, Jonathan P. Hill, Makoto Komiyama, Katsuhiko Ariga
- Journal Title
  
  ACS APPLIED MATERIALS & INTERFACES
  
  Volume: 9 Issue: 36 Pages: 30553-30560
- DOI
  10.1021/acsami.7b11445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189, KAKENHI-PROJECT-15H03831
[Journal Article] Highly efficient preparation of single-stranded DNA rings by T4 ligase at abnormally low Mg(II) concentration2017
- Author(s)
  Ran An, Qi Li, Yiqiao Fan, Jing Li, Xiaoming Pan, Makoto Komiyama, Xingguo Liang
- Journal Title
  
  NUCLEIC ACIDS RESEARCH
  
  Volume: 45 Issue: 15 Pages: e139-e139
- DOI
  10.1093/nar/gkx553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Site-Selective RNA Activation by Acridine-Modified Oligodeoxynucleotides in Metal-Ion Catalyzed Hydrolysis: A Comprehensive Study2017
- Author(s)
  Akinori Kuzuya, Kenzo Machida, Yun Shi, Keita Tanaka, Makoto Komiyama
- Journal Title
  
  ACS OMEGA
  
  Volume: 2 Issue: 9 Pages: 5370-5377
- DOI
  10.1021/acsomega.7b00966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes2016
- Author(s)
  Jun Sumaoka, Hiroki Akiba, Makoto Komiyama
- Journal Title
  
  INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
  
  Volume: 2016 Pages: 1-14
- DOI
  10.1155/2016/3216523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Ribonuclease A as Effective Promoter for Unimolecular Invasion of Peptide Nucleic Acid to Double-stranded DNA2016
- Author(s)
  Makiko Tanaka, Narumi Shigi, Makoto Komiyama
- Journal Title
  
  Chem. Lett.
  
  Volume: 45 Issue: 7 Pages: 767-769
- DOI
  10.1246/cl.160340
- NAID
  130005253013
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Fabrication of DNA/RNA hybrids through sequence-specific scission of both strands by pcPNA-SI nuclease combination2016
- Author(s)
  K. Futai, J. Sumaoka, M. Komiyama
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids
  
  Volume: 35 Issue: 5 Pages: 233-244
- DOI
  10.1080/15257770.2015.1131294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-15H02189
[Journal Article] Design of Highly Active Ce(IV) Catalysts for DNA Hydrolysis and Their Applications2016
- Author(s)
  Makoto Komiyama
- Journal Title
  
  Chem. Lett.
  
  Volume: 45 Issue: 12 Pages: 1347-1355
- DOI
  10.1246/cl.160786
- NAID
  130005475734
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Promotion of double-duplex invasion of peptide nucleic acid through conjugation with nuclear localization signal peptide2015
- Author(s)
  Y. Aiba, Y. Honda, M. Komiyama
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 21 Issue: 10 Pages: 4021-4026
- DOI
  10.1002/chem.201406085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Transfection of PNA–NLS Conjugates into Human Cells Using Partially Complementary Oligonucleotides2015
- Author(s)
  Yuichiro Aiba, Junpei Ohyama, Makoto Komiyama,
- Journal Title
  
  Chem. Lett.
  
  Volume: 44 Issue: 11 Pages: 1547-1549
- DOI
  10.1246/cl.150733
- NAID
  130005108123
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02189
[Journal Article] Affinity Isolation of Desired Restriction Fragment from Human Genome Using Double-duplex Invasion of Biotin-bound Pseudo-complementary PNA2015
- Author(s)
  N. Shigi, A. Rajendran, X. Wang, H. Kunifuda, J. Sumaoka, M. Komiyama
- Journal Title
  
  Chem. Lett.
  
  Volume: 44 Issue: 11 Pages: 1569-1571
- DOI
  10.1246/cl.150682
- NAID
  130005108088
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-15H02189
[Journal Article] Clipping of Telomere from Human Chromosomes using Chemistry-based Artificial Restriction DNA Cutter2015
- Author(s)
  T. Ishizuka, Y. Xu, and M. Komiyama
- Journal Title
  
  Curr. Protoc. Nucleic Acid Chem
  
  Volume: 61
- Description
  in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Chemical modifications of artificial restriction DNA cutter (ARCUT) to promote its in vivo and in vitro applications2015
- Author(s)
  M. Komiyama
- Journal Title
  
  Artificial DNA : PNA & XNA
  
  Volume: 5 Issue: 3 Pages: 1-13
- DOI
  10.1080/1949095x.2015.1112457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Clipping of Telomere from Human Chromosomes using Chemistry-based Artificial Restriction DNA Cutter2015
- Author(s)
  Takumi Ishizuka, Yan Xu, Makoto Komiyama
- Journal Title
  
  Curr. Protoc. Nucleic Acid Chem.
  
  Volume: in press Issue: 1
- DOI
  10.1002/0471142700.nc0613s61
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25888019, KAKENHI-PROJECT-22000007
[Journal Article] Clipping of predetermined fragments from human genome by Slnuclease-PNA combinations2014
- Author(s)
  X. Li, S. Muneoka, N. Shigi, J. Sumaoka, and M. Komiyama
- Journal Title
  
  Chem. Commun.
  
  Volume: 50 Issue: 63 Pages: 8674-8676
- DOI
  10.1039/c4cc01420k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Thiazole orange-conjugated peptide nucleic acid for fluorescent detection of specific DNA sequences and site-selective photodamage2014
- Author(s)
  Tanaka, M, et al.
- Journal Title
  
  RSC advances
  
  Volume: 4 Issue: 108 Pages: 63533-63538
- DOI
  10.1039/c4ra13780a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40062, KAKENHI-PROJECT-22000007
[Journal Article] Orthogonal enzyme arrays on a DNA origami scaffold bearing size-tunable wells2014
- Author(s)
  T. Yamazaki, J.G. Heddle, A. Kuzuya, and M. Komiyama
- Journal Title
  
  Nanoscale
  
  Volume: 6 Issue: 15 Pages: 9122-9126
- DOI
  10.1039/c4nr01598c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-22220001, KAKENHI-PLANNED-24104004, KAKENHI-PROJECT-24350088
[Journal Article] Finding of a human telomere DNA-RNA hybrid G-quadruplex formed by human telomeric 6-mer RNA and 16-mer DNA using click chemistry : Aprotective structure for telomere end2014
- Author(s)
  Y. Xu, Y. Suzuki, T. Ishizuka, C.-D. Xiao, X. Liu, T. Hayashi, and M. Komiyama
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 16 Pages: 4419-4421
- DOI
  10.1016/j.bmc.2014.05.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-25888019, KAKENHI-PROJECT-26288083
[Journal Article] Site-Selective Scission of Human Genome Using PNA-Based Artificial Restriction DNA Cutter2014
- Author(s)
  K. Ito and M. Komiyama
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1050 Pages: 111-120
- DOI
  10.1007/978-1-62703-553-8_9
- ISBN
  9781627035521, 9781627035538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Molecular Crowding Facilitates Double-duplex Invasion of Pseudo-complementary Peptide Nucleic Acid in High-salt Medium2014
- Author(s)
  J. Sumaoka and M. Komiyama
- Journal Title
  
  Chem. Lett.
  
  Volume: 43 Issue: 10 Pages: 1581-1583
- DOI
  10.1246/cl.140620
- NAID
  130004693816
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] PNA-NLS conjugates as single-molecular activators of target sites in double-stranded DNA for site-selective scission2013
- Author(s)
  Y. Aiba, Y. Hamano, W. Kameshima, Y. Araki, T. Wada, A. Accetta, S. Sforza, R. Corradini, R. Marchelli, and M. Komiyama
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 11 Issue: 32 Pages: 5233-5238
- DOI
  10.1039/c3ob40947c
- NAID
  120007130454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PLANNED-24120005, KAKENHI-PROJECT-24245044
[Journal Article] Site-selective Scission of Double-stranded DNA by Combining a Triplex-forming bis-PNA and Ce(IV)/EDTA2013
- Author(s)
  Y. Aiba, K. Yasuda. and M. Komiyama
- Journal Title
  
  Chem. Lett.
  
  Volume: 42 Issue: 10 Pages: 1300-1302
- DOI
  10.1246/cl.130650
- NAID
  10031201345
- ISSN
  0366-7022, 1348-0715
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Cut-and-paste of DNA using artificial restriction DNA cutter2013
- Author(s)
  M. Komiyama
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 14 Pages: 3343-3357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] A Chemistry-Based Method to Detect Individual Telomere Lengths at a Single Chromosome Terminus2013
- Author(s)
  T. Ishizuka, Y. Xu, and M. Komiyama
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 135 Issue: 1 Pages: 14-17
- DOI
  10.1021/ja308481c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-22350071, KAKENHI-PROJECT-24651264
[Journal Article] DNAを切る唯一の触媒―セリウムとの幸運な出会い―2013
- Author(s)
  小宮山眞
- Journal Title
  
  別冊化学"ケミストを魅了した元素と周期律表"
  
  Volume: 5月号 Pages: 12-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Direct light-up of cAMP derivatives in living cells by click reactions2013
- Author(s)
  K. Ito, H. Liu, M. Komiyama, T. Hayashi, and Y. Xu
- Journal Title
  
  Molecules
  
  Volume: 18 Issue: 10 Pages: 12909-12915
- DOI
  10.3390/molecules181012909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-24651264
[Journal Article] An artificial restriction DNA cutter for site-selective gene insertion in human cells.2013
- Author(s)
  Kenichiro Ito, Narumi Shigi, Makoto Komiyama
- Journal Title
  
  Chemical Communications
  
  Volume: 49 Issue: 60 Pages: 6764-6766
- DOI
  10.1039/c3cc43261k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07727, KAKENHI-PROJECT-22000007
[Journal Article] Conjugation of peptide nucleic acid with pyrrole-imidazole polyamide to specifically recognize and cleave DNA2013
- Author(s)
  W. Kameshima, T. Ishizuka, M. Minoshima, H. Sugiyama, Y. Xu, and M. Komiyama
- Journal Title
  
  Angew. Chem. Int. Ed. Engl.
  
  Volume: 52 Issue: 51 Pages: 13681-13684
- DOI
  10.1002/anie.201305489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-24651264
[Journal Article] Evidence for G-quadruplex DNA in human cells2013
- Author(s)
  Y. Xu and M. Komiyama
- Journal Title
  
  Chembiochem.
  
  Volume: 14 Issue: 8 Pages: 927-928
- DOI
  10.1002/cbic.201300157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-22350071, KAKENHI-PROJECT-24651264
[Journal Article] Design and Applications of Artificial Restriction DNA Cutters for Site-Selective Scission of Genomes2012
- Author(s)
  M. Komiyama
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 85 Issue: 5 Pages: 533-544
- DOI
  10.1246/bcsj.20110318
- NAID
  130004153074
- ISSN
  0009-2673, 1348-0634
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres2012
- Author(s)
  Yan Xu, Takumi Ishizuka, Jie Yang, Kenichiro Ito, Hitoshi Katada, Makoto Komiyama, Tetsuya Hayashi
- Journal Title
  
  J. Bio. Chem.
  
  Volume: Vol. 287 Issue: 50 Pages: 41787-41796
- DOI
  10.1074/jbc.m112.342030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07372, KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-22350071, KAKENHI-PROJECT-24651264
[Journal Article] Structure, function and targeting of human telomere RNA2012
- Author(s)
  Y. Xu and M. Komiyama
- Journal Title
  
  Methods
  
  Volume: 57 Issue: 1 Pages: 100-105
- DOI
  10.1016/j.ymeth.2012.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007, KAKENHI-PROJECT-22350071, KAKENHI-PROJECT-24651264
[Journal Article] 高等生物を対象とした新しいバイオテクノロジー　　－スーパー制限酵素（化学合成ツール）の活用―2012
- Author(s)
  小宮山　眞
- Journal Title
  
  未来材料
  
  Volume: 12 Pages: 64-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Artificial restriction DNA cutters to promote homologous recombination in human cells2011
- Author(s)
  H.Katada, M.Komiyama
- Journal Title
  
  Current Gene Therapy
  
  Volume: 11 Pages: 38-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Nanomechanical DNA Origami 'Single-Molecule Beacons' Directly Imaged by Atomic Force Microscopy2011
- Author(s)
  A.Kuzuya, M.Komiyama
- Journal Title
  
  Nature Commun.
  
  Volume: 2 Pages: 449-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Photo-Switching of Site-Selective RNA Scission by Sequential Icorporation of Azobenzene and Acridine Residues in a DNA Oligomer2011
- Author(s)
  A.Kuzuya, M.Komiyama
- Journal Title
  
  J.Nucl.Acids
  
  Volume: 2011 Pages: 162452-162452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Manipulation of single-stranded DNA using artificial site-selective DNA cutter composed of Ce(IV)/EDTA and phosphonate-oligonucleotide conjugates2010
- Author(s)
  Y.Aiba, M.Komiyama
- Journal Title
  
  Chem.Asian J.
  
  Volume: 6 Pages: 2407-2411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000007
[Journal Article] Oxidation of Oligonucleotide-bound CeIII/Multiphosphonate Complex for Site-Selective DNA Scission2010
- Author(s)
  T.Lonnberg, Y.Aiba, Y.Hamano, Y.Miyajima, J.Sumaoka, M.Komiyama
- Journal Title
  
  Chem.Eur.J. 16
  
  Pages: 855-859
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Human Telomeric DNA Sequence-Specific Cleaving by G-Quadruplex Formation2009
- Author(s)
  Y. Xu, Y. Suzuki, T. Lonnberg, M. Komiyama
- Journal Title
  
  J. Am. Chem. Soc 131
  
  Pages: 2871-2874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Strand Invasion of Conventional PNA to Arbitrary Sequence in DNA Assisted by Single-Stranded DNA Binding Protein2009
- Author(s)
  T. Ishizuka, K. Otani, J. Sumaoka, M. Komiyama
- Journal Title
  
  Chem. Commun
  
  Pages: 1225-1227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Strand Invasion of Conventional PNA to Arbitrary Sequence in DNA Assisted by Single-Stranded DNA Binding Protein2009
- Author(s)
  T.Ishizuka, K.Otani, J.Sumaoka, M.Komiyama
- Journal Title
  
  Chem.Commun.
  
  Pages: 1225-1227
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Origin of High Fidelity in Target-Sequence Recognition by PNA Ce(IV)/EDTA Combinations as Site-Selective DNA Cutters2009
- Author(s)
  Y.Miyajima, T.Ishizuka, Y.Yamamoto, J.Sumaoka, M.Komiyama
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 2657-2662
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Human Telomeric DNA Sequence-Specific Cleaving by G-Quadruplex Formation2009
- Author(s)
  Y.Xu, Y.Suzuki, T.Lonnberg, M.Komiyama
- Journal Title
  
  J.Am.Chem.Soc. 131
  
  Pages: 2871-2874
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Site-Selective Scission of Human Genome by Artificial Restriction DNA Cutter2009
- Author(s)
  K.Ito, H.Katada, N.Shigi, M.Komiyama
- Journal Title
  
  Chem.Commun.
  
  Pages: 6542-6544
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Origin of High Fidelity in Target-Sequence Recognition by PNA Ce(IV)/EDTA Combinations as Site-Selective DNA Cutters2009
- Author(s)
  Y. Miyajima, T. Ishizuka, Y. Yamamoto, J. Sumaoka, M. Komiyama
- Journal Title
  
  J. Am. Chem. Soc 131
  
  Pages: 2657-2662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Precise Site-Selective Termination of DNA Replication by Caging The 3-Position of Thymidine and Its Application to Polymerase Chain Reaction2009
- Author(s)
  A.Kuzuya, F.Okada, M.Komiyama
- Journal Title
  
  Bioconjugate Chem. 30
  
  Pages: 1924-1929
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] SSB-Assisted Duplex Invasion of Preorganized PNA into Double-Stranded DNA2009
- Author(s)
  T.Ishizuka, T.Tedeschi, R.Corradini, M Komiyama, S.Sforza, R.Marchelli
- Journal Title
  
  Chem Bio Chem 10
  
  Pages: 2607-2612
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Introduction of Disulfide Bond to the Main Chain of PNA to Switch Its Hybridization and Invasion Activity2009
- Author(s)
  Y.Aiba, M.Komiyama
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 5078-5083
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Artificial Restriction DNA Cutters as New Tools for Gene Manipulation2009
- Author(s)
  H.Katada, M.Komiyama
- Journal Title
  
  Chem Bio Chem 10(DOI)
  
  Pages: 1279-1288
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Homologous Recombination in Human Cells using Artificial Restriction DNA Cutter2009
- Author(s)
  H.Katada, H.J.Chen, N.Shigi, M.Komiyama
- Journal Title
  
  Chem.Commun.
  
  Pages: 6545-6547
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Artificial Restriction DNA Cutter for Site-Selective Scission of Double-Stranded DNA with Tunable Scission Site and Specificity2008
- Author(s)
  M.Komiyama
- Journal Title
  
  Nat.Protoc. 3
  
  Pages: 655-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Solid-Phase Synthesis of Pseudo-Complementary Peptide Nucleic Acids2008
- Author(s)
  M.Komiyama, Y.Aiba, T.Ishizuka
- Journal Title
  
  J.Sumaoka, Nat.Protoc. 3
  
  Pages: 646-654
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Artificial Restriction DNA Cutter for Site-Selective Scission of Double-Stranded GDNA with Tunable Scission Site and Specificity2008
- Author(s)
  M.Komiyama, Y.Aiba, Y.Yamamoto, J.Sumaoka
- Journal Title
  
  Nat.Protoc. 3
  
  Pages: 655-662
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Artificial Restriction DNA Cutter for Site-Selective Scission of Double-Stranded DNA with Tunable Scission Site and Specificity2008
- Author(s)
  M. Komiyama, Y. Aiba, Y. Yamamoto, J. Sumaoka
- Journal Title
  
  Nat. Protoc. 3
  
  Pages: 655-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Site-Selective Blocking of PCR by a Caged Nucleotide Leading to Direct Creation of Desired Sticky Ends in the Products2008
- Author(s)
  K. Tanaka, H. Katada, N. Shigi, A. Kuzuya, M. Komiyama
- Journal Title
  
  Chem Bio Chem 9
  
  Pages: 2120-2126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Solid-Phase Synthesis of Pseudo-Complementary Peptide Nucleic Acids2008
- Author(s)
  M. Komiyama, Y. Aiba, T. Ishizuka, J. Sumaoka
- Journal Title
  
  Nat. Protoc. 3
  
  Pages: 646-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Chiral Introduction of Positive Charges to PNA for Double-Duplex Invasion to Versatile Sequences2008
- Author(s)
  T.Ishizuka, J.Yoshida, Y.Yamamoto, J.Sumaoka, T.Tedeschi, R.Corradini, S.Sforza, M.Komiyama
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1464-1471
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Solid-Phase Synthesis of Pseudo-Complementary Peptide Nucleic Acids2008
- Author(s)
  M.Komiyama
- Journal Title
  
  Nat.Protoc. 3
  
  Pages: 646-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Prompt Site-Selective DNA Hydrolysis by Ce(IV)-EDTA Using Oligonucleotide Multiphosphonate Conjugates2008
- Author(s)
  T. Lonnberg, Y. Suzuki, M. Komiyama
- Journal Title
  
  Org. Biomol. Chem 6
  
  Pages: 3580-3587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Accommodation of a Single Protein Guest in Nanometer-Scale Wells Embedded in a "DNA Nanotape"2008
- Author(s)
  A. Kuzuya, K. Numajiri, M. Komiyama
- Journal Title
  
  Angew. Chem., Int. Ed. 47
  
  Pages: 3400-3402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Site-Selective Blocking of PCR by a Caged Nucleotide Leading to Direct Creation of Desired Sticky Ends in The Products2008
- Author(s)
  K.Tanaka, H.Katada, N.Shigi, A.Kuzuya, M.Komiyama
- Journal Title
  
  Chem Bio Chem 9
  
  Pages: 2120-2126
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Prompt Site-Selective DNA Hydrolysis by Ce(IV)-EDTA Using Oligonucleotide Multiphosphonate Conjugates2008
- Author(s)
  T.Lonnberg, Y.Suzuki, M.Komiyama
- Journal Title
  
  Org.Biomol.Chem. 6
  
  Pages: 3580-3587
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Chiral Introduction of Positive Charges to PNA for Double-Duplex Invasion to Versatile Sequences2008
- Author(s)
  T. Ishizuka, J. Yoshida, Y. Yamamoto, J. Sumaoka, T. Tedeschi, R. Corradini, S. Sforza, M. Komiyama
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 1464-1471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18001001
[Journal Article] Oligonucleotide bearing ethylenediamine-N, N, N'-triacetates for gap-selective DNA hydrolysis by Ce^<4+>/EDTA.2005
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  ChemBioChem. 6
  
  Pages: 192-196
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Oligonucleotide bearing ethylenediamine-N,N,N'-triacetates for gap-selective DNA hydrolysis by Ce^<4+>/EDTA.2005
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  ChemBioChem. 6
  
  Pages: 192-196
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 制限酵素2005
- Author(s)
  小宮山真
- Journal Title
  
  日経バイオビジネス
  
  Pages: 48-51
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 制限酵素2005
- Author(s)
  小宮山真
- Journal Title
  
  日経バイオビジネス 2005
  
  Pages: 48-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 人工制限酵素による巨大DNAの選択的切断と遺伝子操作2005
- Author(s)
  小宮山真
- Journal Title
  
  Bioベンチャー 5
  
  Pages: 79-81
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 人工制限酵素を用いた遺伝子操作2005
- Author(s)
  小宮山真
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 81-86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Cutting DNA and RNA2004
- Author(s)
  M.Komiyama
- Journal Title
  
  Handbook on the Physics and Chemistry of Rare Earths 34
  
  Pages: 405-453
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Cutting DNA and RNA.2004
- Author(s)
  M.Komiyama
- Journal Title
  
  Handbook on the Physics and Chemistry of Rare Earths 34
  
  Pages: 405-453
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Oligonucleotide bearing ethylenediamine-N,N,N'-triacetates for gap-selective DNA hydrolysis by Ce^<4+>/EDTA.2004
- Author(s)
  Komiyama, M.et al.
- Journal Title
  
  ChemBioChem. 6
  
  Pages: 192-196
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 次世代バイオテクノロジーと化学-人工制限酵素とその応用を中心として-2003
- Author(s)
  小宮山真
- Journal Title
  
  ファルマシア 39
  
  Pages: 137-141
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] PNA for one-base differentiating protection of DNA from nuclease and its use for SNPs detection.2003
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  J.Am.Chem.Soc 125
  
  Pages: 3758-3762
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] PNA for one-base differentiating protection of DNA from nuclease and its use for SNPs detection.2003
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  J.Am.Chem.Soc. 125
  
  Pages: 3758-3762
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Sequence-selective scission of DNA and RNA by lanthanide ions and their complexes2003
- Author(s)
  M.Komiyama.
- Journal Title
  
  Metal Ions in Biological Systems 40
  
  Pages: 463-476
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Lanthanide-promoted Peptide Hydrolysis2003
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  Metal Ions in Biological Systems 40
  
  Pages: 355-368
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Sequence-selective scission of DNA and RNA by lanthanide ions and their complexes2003
- Author(s)
  M.Komiyama
- Journal Title
  
  Metal Ions in Biological Systems 40
  
  Pages: 463-476
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Site-selective activation of RNA leading to sequence-selective RNA cutters.2002
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  Bull.Chem.Soc.Jpn.(Account) 75
  
  Pages: 2547-2554
- NAID
  10010679515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 化学の力でRNAを望みの位置で切断する2002
- Author(s)
  小宮山真ほか
- Journal Title
  
  化学と教育 50
  
  Pages: 576-577
- NAID
  110008592683
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Site-selective activation of RNA leading to sequence-selective RNA cutters.2002
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  Bull.Chem.Soc.Jpn. 75
  
  Pages: 2547-2554
- NAID
  10010679515
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] Trinuclear copper(II) complex showing high selectivity for the hydrolysis of 2'-5' over 3'-5' for UpU and 3'-5' over 2'-5' for ApA ribonucleotides.2002
- Author(s)
  M.Komiyama et al.
- Journal Title
  
  J.Am.Chem.Soc. 124
  
  Pages: 13731-13736
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 核酸の材料素材としての活用2002
- Author(s)
  小宮山真ほか
- Journal Title
  
  化学 57
  
  Pages: 23-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Journal Article] 化学が作る次世代のバイオテクノロジー2002
- Author(s)
  小宮山真ほか
- Journal Title
  
  未来材料 2
  
  Pages: 10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132204
[Patent] 粘着末端を有するDNA断片の調製法2008
- Inventor(s)
  小宮山眞・葛谷明紀・田中啓太
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2008-061678
- Filing Date
  2008-03-11
- Data Source
  KAKENHI-PROJECT-18001001
[Patent] 標的核酸を位置選択的に切断する方法2007
- Inventor(s)
  小宮山眞、レンベルク・トーマス、鈴木啓太
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2007-11-19
- Data Source
  KAKENHI-PROJECT-18001001
[Patent] 粘着末端を有するDNA断片の調製方法2007
- Inventor(s)
  小宮山眞、葛谷明紀、田中啓太
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2008-061678
- Filing Date
  2007-03-11
- Data Source
  KAKENHI-PROJECT-18001001
[Patent] 標的核酸を位置選択的に切断する方法2007
- Inventor(s)
  小宮山眞・レンベルクトーマス・鈴木裕太
- Industrial Property Rights Holder
  国立大学法人東京大学
- Filing Date
  2007-11-19
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] リボヌクレアーゼAによる単一鎖ペプチド核酸の二本鎖DNAへのインベージョン促進2016
- Author(s)
  田仲真紀子、鴫成実、小宮山眞
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学　京田辺キャンパス(京都府京田辺市)
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] リボヌクレアーゼAによる単一鎖ペプチド核酸の二本鎖DNAへのインベージョン促進2016
- Author(s)
  田仲真紀子・鴫成実・小宮山眞
- Organizer
  日本化学会96春季年会
- Place of Presentation
  同志社大学京田辺キャンパス(京都府・京田辺市)
- Year and Date
  2016-03-25
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] リボヌクレアーゼAによる単一鎖ペプチド核酸の二本鎖DNAへのインベージョン促進2015
- Author(s)
  田仲　真紀子、鴫　成実、小宮山　眞
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市)
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] シクロデキストリン科学の変遷2015
- Author(s)
  小宮山眞
- Organizer
  第8回アジアンシクロデキストリンカンファレンス/第32回シクロデキストリンシンポジウム合同会議
- Place of Presentation
  くまもと県民交流館パレア(熊本県熊本市)
- Year and Date
  2015-05-15
- Invited
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] ビオチン化pcPNAプローブによるヒトゲノムの特定領域断片の濃縮法の開発2015
- Author(s)
  鴫(日野)　成実、アリワラガン　ラジェンドラン、王　曉輝、国府田　寛子、須磨岡　淳、小宮山　眞
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市)
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] Covalent and Noncovalent Approaches to Promote PNA Invasion for In Vivo Applications2015
- Author(s)
  Makoto Komiyama
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii (USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] ビオチン化pcPNAプローブによるヒトゲノムの特定領域断片の濃縮法の開発2015
- Author(s)
  鴫(日野) 成実, アリワラガンラジェンドラン, 王曉輝, 国府田寛子, 須磨岡淳, 小宮山眞
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県・神戸市)
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Chemical Tools to Isolate a Desired Fragment from Human Genome2015
- Author(s)
  Makoto Komiyama
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii (USA)
- Year and Date
  2015-12-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Covalent and Noncovalent Approaches to Promote PNA Invasion for In Vivo Applications2015
- Author(s)
  Makoto Komiyama
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii (USA)
- Year and Date
  2015-12-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Chemical Tools to Isolate a Desired Fragment from Human Genome.2015
- Author(s)
  Makoto Komiyama
- Organizer
  The 2015 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii (USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] RNase A添加によるDNAへのペプチド核酸のインベージョン促進2015
- Author(s)
  田仲真紀子・鴫成実・小宮山眞
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド(兵庫県・神戸市)
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] シクロデキストリン化学の変遷2015
- Author(s)
  小宮山眞
- Organizer
  8th Asian Cyclodextrin Conference/第32回シクロデキストリンシンポジウム合同会議
- Place of Presentation
  くまもと県民交流館パレア(熊本県熊本市)
- Year and Date
  2015-05-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02189
[Presentation] チアゾールオレンジ修飾ペプチド核酸による二本鎖DNA中での特定配列の蛍光検出と位置選択的光損傷2015
- Author(s)
  田仲真紀子、鴫成美、須磨岡淳、小宮山眞
- Organizer
  第95回日本化学会春季年会
- Place of Presentation
  日本大学船橋キャンパス(千葉県船橋市)
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Site-specific scission of human genome for efficient isolation of its specific region2014
- Author(s)
  A. Rajendran, N. Shigi, X. Li, J. Sumaoka, M. Komiyama
- Organizer
  The 41st International symposium on nucleic acids chemistry
- Place of Presentation
  Kitakyushu international conference center(福岡県北九州市)
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Sequence specific cleavage of DNA/RNA hybrids2013
- Author(s)
  Kazuki Futai, Makoto Komiyama
- Organizer
  ISNAC2013第40回国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学(神奈川)
- Year and Date
  2013-11-13
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素ARCUTを用いたヒト細胞内における相同組換え2013
- Author(s)
  池戸　彰之 , 鴫　成実 , 須磨岡　淳 , 小宮山　眞
- Organizer
  日本化学会第93春季年会
- Place of Presentation
  立命館大学びわこ・くさつキャンパス（滋賀県）
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 分子クラウディング効果によるPNAインベージョンの促進2013
- Author(s)
  須磨岡淳, 小宮山眞
- Organizer
  第7回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋大学東山キャンバス(愛知県)
- Year and Date
  2013-09-29
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工DNAカッター（ARCUT)による細胞内DNA切断2012
- Author(s)
  愛場　雄一郎 , 本田　祐太 , 韓　悦 , 亀島　渡 , 濱野　悠也 , 須磨岡　淳 , 鴫　成実 , 小宮山　眞
- Organizer
  第6回バイオ関連化学シンポジウム
- Place of Presentation
  北海道大学高等教育推進機構（北海道）
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] PNAへのNLS修飾によるインベージョンの高効率化とDNA切断への応用2012
- Author(s)
  愛場　雄一郎 , 本田　祐太 , 亀島　渡 , 濱野　悠 , Accetta Alessandro , Sforza Stefano , Marchelli Rosangela , Corradini Roberto , 小宮山　眞
- Organizer
  第22回バイオ・高分子シンポジウム
- Place of Presentation
  東京大学先端科学技術研究センター（東京）
- Year and Date
  2012-06-25
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Manipulation of Huge DNA by Artificial Restriction DNA Cutter (ARCUT).2011
- Author(s)
  M. Komiyama
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Cambridge (UK)
- Invited
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 骨格中へのリンカー導入によるPNAのミスマッチ識別能向上2011
- Author(s)
  西山友加里、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] PNA Peptide eonjugateを利用したDNA位置選択的切断2011
- Author(s)
  愛場雄一郎、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Pinpoint Manipulation of Human Genome Using Artificial DNA Cutter2011
- Author(s)
  M.Komiyama
- Organizer
  G-COE symposium in Nagoya on Biochemistry and Bionanotechnology
- Place of Presentation
  名古屋
- Year and Date
  2011-01-12
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 単分子検出デバイスとしての可動式DNAオリガミ2011
- Author(s)
  葛谷明紀、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] ARCUTによる単一染色体のテロメア長測定2011
- Author(s)
  石塚匠、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] ナノメカニカルDNAオリガミデバイスは"単分子"ビーコンとして機能する2011
- Author(s)
  葛谷明紀、小宮山眞
- Organizer
  第13回生命化学研究会シンポジウム(冬季)
- Place of Presentation
  東北大学
- Year and Date
  2011-01-07
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Genome Manipulation Using Chemistry-based Artificial Restriction DNA Cutters2011
- Author(s)
  M.Komiyama
- Organizer
  6th Cambridge Symposium on Nucleic Acids Chemistry and Biology
- Place of Presentation
  Queens College, Cambridge, UK
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 化学ツールを活用したゲノム工学の創成2011
- Author(s)
  小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial DNA cutter to manipulate huge genome.2011
- Author(s)
  M. Komiyama
- Organizer
  15th Symposium on Chemistry of Nucleic Acid Compounds
- Place of Presentation
  Cesky Krumlov (Czech Republic)
- Invited
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] ヒトテロメアRNAの構造と生化学機能について2011
- Author(s)
  徐岩、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素を用いた遺伝子ノックアウト法の開発2011
- Author(s)
  伊藤健一郎, 小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] アロステリック酵素を模倣した可動式DNAオリガミによる高感度単分子検出2011
- Author(s)
  葛谷明紀、小宮山眞
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(東日本大震災の影響で)(紙面・Web上での開催のみ)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Incorporation of a flexible linker into pseudo-complementary PNA for the strict recognition of DNA2010
- Author(s)
  Yuichiro Aiba, Makoto Komiyama
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  Yokohama
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] DNA Origamiの構造変化に基づく非共有結合形成の単分子検出2010
- Author(s)
  酒井雄介、小宮山眞
- Organizer
  第4回バイオ関連化学シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial restriction DNA cutter (ARCUT) for homologous recombination in human cells2010
- Author(s)
  M.Komiyama
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial Restriction DNA Cutter for Manipulation of Huge DNA2010
- Author(s)
  Makoto Komiyama
- Organizer
  BIOCHEMISTRY and MEDICAL CHEMISTRY : BIOMEDCH'10
- Place of Presentation
  University of Cambridge
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] Artificial restriction DNA cutter for targeted gene knockout2010
- Author(s)
  Kenichiro Ito, Makoto Komiyama
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  Yokohama
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] DNA hydrolysis by Ce(IV) complex prepared from Ce(III) precursor2010
- Author(s)
  M.Komiyama
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial Restriction DNA Cutter for Manipulation of Huge DNA2010
- Author(s)
  Makoto Komiyama
- Organizer
  BIOCHEMISTRY and MEDICAL CHEMISTRY : BIOMEDCH'10, University of Cambridge, Cambridge, UK
- Place of Presentation
  Plenary Lecture
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] 機能性リンカー導入による新規PNA修飾法の開発2010
- Author(s)
  愛場雄一郎、小宮山眞
- Organizer
  第22回生体機能関連化学部会若手の会サマースクール
- Place of Presentation
  三重県
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 単一のPNA-peptideコンジュゲートを利用した位置選択的DNA切断2010
- Author(s)
  愛場雄一郎、小宮山眞
- Organizer
  第4回バイオ関連化学合同シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Site-selective scission of double-stranded DNA by Ce(IV)/EDTA and only one mixed-base PNA2010
- Author(s)
  Yuichiro Aiba, Makoto Komiyama
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素ARCUTによるヒトゲノムの遺伝子ターゲティング法の開発2010
- Author(s)
  鴫(日野)成実, 小宮山眞
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 単一のPNA-peptideコンジュゲートを利用した位置選択的DNA切断2010
- Author(s)
  愛場雄一郎、小宮山眞
- Organizer
  第25回生体機能関連化学シンポジウム若手フォーラム
- Place of Presentation
  大阪大学
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Strict recognition of double-stranded DNA by chemically modified PNA (Peptide Nucleic Acid)2010
- Author(s)
  Yuichiro Aiba, Makoto Komiyama
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial conversion of a gene in human genome2010
- Author(s)
  M.Komiyama
- Organizer
  Workshop on Nucleic Acid Chemistry
- Place of Presentation
  Telluride, USA
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素による相同組換えの促進とゲノム工学への応用2010
- Author(s)
  堅田仁、小宮山眞
- Organizer
  第20回バイオ・高分子シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2010-07-29
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素を用いたヒト細胞おけるジーンターゲティング法の開発2010
- Author(s)
  鴫成実, 小宮山眞, 須磨岡淳
- Organizer
  第4回バイオ関連化学合同シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Artificial restriction DNA cutter as homologous recombination stimulator for genome engineering2010
- Author(s)
  Hitoshi Katada, Makoto Komiyama
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素を用いたヒト生細胞内でのゲノムの位置特異的切断法の開発2010
- Author(s)
  野口恵理, 小宮山眞
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] G-Rich Sequence-Specific Cleaving by PNA/DNA Hybrid G-Quadruplex Formation2010
- Author(s)
  Takumi Ishizuka, Makoto Komiyama
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] 人工制限酵素を用いたヒトゲノムの位置特異的切断2009
- Author(s)
  伊藤健一郎、堅田仁、鴫成実、小宮山眞
- Organizer
  第24回生体機能関連化学シンポジウム、1P-117
- Place of Presentation
  福岡
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] リン酸系配位子による人工DNAカッターARCUTの高効率化2009
- Author(s)
  愛場雄一郎、濱野悠也、河邉明博、鈴木裕太、Tuomas Lonnberg、徐岩、須磨岡淳、小宮山眞
- Organizer
  第19回バイオ・高分子シンポジウム、23
- Place of Presentation
  東京
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] ポリメラーゼ反応を局所的に停止させる新規ケージドヌクレオチドの合成とPCRへの応用2009
- Author(s)
  岡田文徳、葛谷明紀、小宮山眞
- Organizer
  第24回生体機能関連化学シンポジウム、1P-123
- Place of Presentation
  福岡
- Year and Date
  2009-09-14
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] 人工制限酵素を用いたヒトゲノムの位置特異的切断2009
- Author(s)
  伊藤健一郎、堅田仁、鴫成実、小宮山眞
- Organizer
  日本化学会第89春季年会、2H6-16
- Place of Presentation
  千葉
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] Molecular design and application of artificial restriction nuclease2009
- Author(s)
  Makoto Komiyama
- Organizer
  14^<th> International Conference on Biological Inorganic Chemistry (ICBIC 14)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] Artificial Restriction DNA CUTter (ARCUT) : a powerful tool for gene targeting in human cell mediated by homologous recombination2009
- Author(s)
  鴫成実、堅田仁、陳萱容、伊藤健一郎、野口恵理、小宮山眞
- Organizer
  第32回分子生物学会年会、3P-0848
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] Genome manipulation using artificial restriction DNA cutter (ARCUT)2009
- Author(s)
  Makoto Komiyama
- Organizer
  International Symposium on "Multifunctional Organic Materials and Devices"
- Place of Presentation
  Chiba
- Data Source
  KAKENHI-PROJECT-18001001
[Presentation] Site-specific Scission and Recombination　of Human Mitochondrial DNA by Using Artificial Restriction DNA Cutter
- Author(s)
  鴫（日野）　成実 , 春元　俊正 , 小宮山　眞
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡）
- Year and Date
  2012-12-11 – 2012-12-14
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] PNA/DNA Hybrid G-Quadruplex Formation as a Novel Approach
- Author(s)
  Takumi Ishizuka , Yan Xu , Makoto Komiyama
- Organizer
  ISNAC2012　第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学豊田講堂（愛知県）
- Year and Date
  2012-11-15 – 2012-11-17
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Manipulation of Human Genome Using Completely Chemistry-Based DNA Cutter
- Author(s)
  小宮山眞
- Organizer
  BIO'12 8th WSEAS International Conference on CELLULAR and MOLECULAR BIOLOGY,BIOPHYSICS and BIOENGINEERING
- Place of Presentation
  モントルー（スイス）
- Year and Date
  2012-12-29 – 2012-12-31
- Invited
- Data Source
  KAKENHI-PROJECT-22000007
[Presentation] Chemistry-based restriction DNA cutter for genome manipulation
- Author(s)
  M. Komiyama
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Invited
- Data Source
  KAKENHI-PROJECT-22000007

1. SUMAOKA Jun (10280934)

# of Collaborated Projects: 10 results

# of Collaborated Products: 24 results
2. ASANUMA Hiroyuki (20282577)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YASHIRO Morio (30192785)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KOBAYASHI Masami (70234846)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 3 results

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7. 佐々木政子 (00090514)

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9. 藤田斉 (10096258)

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10. 鈴木正康 (70226554)

# of Collaborated Projects: 3 results

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11. 竹内俊文 (70179612)

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12. 民谷栄一 (60179893)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. INOUE Shohei (20010762)

# of Collaborated Projects: 2 results

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14. XU Yan (40506763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
15. SHIGI Narumi (00396780)

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23. HIGUCHI Maiko (30420235)

# of Collaborated Projects: 1 results

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24. AIBA Yuichiro (10581085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
25. SHIGEKAWA Hidemi (20134489)

# of Collaborated Projects: 1 results

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26. GOTO Masahiro (10211921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KOBATAKE Eiry (00225484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. AIZAWA Masuo (00016742)

# of Collaborated Projects: 1 results

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29. KUNITAKE Toyoki (40037734)

# of Collaborated Projects: 1 results

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30. Tanaka Makiko (90397703)

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37. 重政好弘 (00032029)

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38. 戸倉清一 (40000806)

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# of Collaborated Projects: 1 results

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41. 大内辰郎 (34416404)

# of Collaborated Projects: 1 results

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42. 小宮山真 (18001001)

# of Collaborated Projects: 1 results

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43. 後藤八重子 (00092388)

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46. NAKAZATO Masataka

# of Collaborated Projects: 1 results

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47. DAIKUZONO Norio

# of Collaborated Projects: 1 results

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48. 池上正

# of Collaborated Projects: 1 results

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49. 大工園則男

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 庄司真紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
51. A. RAJENDRAN

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 石塚匠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOMIYAMA Makoto 小宮山 眞

小宮山 真 コミヤマ マコト

Research Projects

Research Products

Co-Researchers

Creation of new genome science using chemical tools to precisely detect modification and damage of human genomePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Creation of genome manipulation technology using super restriction enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Gene Manipulation of Huge DNA by Super Artificial Restriction EnzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AFMによる1分子DNA/金電極系デバイスの電気伝導度測定Principal Investigator

Principal Investigator

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人工DNAカッターを用いた巨大DNAのマニピュレーションPrincipal Investigator

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New Chemical Approaches for Functional of DNA/RNAPrincipal Investigator

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Artificial Restriction Enzymes for Future Nucleic Acids ChemistryPrincipal Investigator

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複数金属イオンを用いたRNA加水分解触媒の構築とリボザイムの作用機構の解明Principal Investigator

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複数金属イオンを用いたRNA加水分解触媒構築とリボザイムの作用機構の解明Principal Investigator

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Preparation of Artificial nuclease and creation of new-biotechnologyPrincipal Investigator

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複数金属イオンを用いたRNA加水分解触媒の構築とリボザイムの作用機構の解明Principal Investigator

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KOMIYAMA Makoto 小宮山眞

小宮山真コミヤママコト