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NAKASHIMA Yutaka  中島 豊

ORCIDConnect your ORCID iD *help
Researcher Number 50135349
Other IDs
External Links
Affiliation (based on the past Project Information) *help 1999 – 2003: Graduate School of Med.Sci.KYUSHU UNIVERSITY Assoc.Prof., 大学院・医学研究院, 助教授
2000: KYUSHU UNIVERSITY, Graduate School of Medical Science, Associate Professor, 大学院・医学系研究院, 助教授
1999: 九州大学, 大学院・医学系研究科, 助教授
1991 – 1998: 九州大学, 医学部, 助教授
1989 – 1990: 九州大学, 医学部, 講師
1988: 九州大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Human pathology / Experimental pathology
Except Principal Investigator
Human pathology / Experimental pathology / Public health/Health science / Circulatory organs internal medicine / Experimental pathology
Keywords
Principal Investigator
atherosclerosis / shear stress / PECAM-1 / ICAM-1 / VCAM-1 / 動脈硬化 / 高血圧 / Hisayama study / coronary artery / hypertension … More / obesity / hyperlipidemia / risk factors / epidemiology / 肥 満 / 久山町 / 冠状動脈 / 肥満 / 高脂血症 / 危険因子 / 疫学調査 / monocyte / in situ immnocytochemistry / ApoE-deficient mouse / in situ免疫法 / 遺伝子欠損マウス / 接着因子 / in situ免疫染色 / P-selectin / E-selectin / apollipoproteinE欠損マウス / 単球 / in situ 免疫染色 / apolipoprotein E 欠損マウス / β-aminopropionitrile / 解離性大動脈瘤 / ラチリズム / 走査電顕 / 透過電顕 / 弾性線維 / βーaminopropionitrile / ラット / 解離性大動脈癌 … More
Except Principal Investigator
血管新生 / VEGF / 動脈硬化 / FGF-2 / 遺伝子導入 / 遺伝子治療 / 血管内皮細胞 / Angiogenesis / MCP-1 / 血管リモデリング / Gene Transfer / Endothelial Cell / angiogenesis / gene therapy / atherosclerosis / SeV / HGF / 血管新生病 / Sev / 血栓症 / PTCA / 内皮細胞 / p53 / 重症虚血肢 / センダイウイルスベクター / gene transfer / Vascular Remodeling / Gene Therapy / vascular remodeling / 転写因子 / NO / Gene transfer / Macrophages / Endothelial cells / IL-1 / マクロファージ / センダイウイルス / Sevベクター / デコイオリゴ / 接着蛋白 / サイトカイン / 血栓 / 血管平滑筋細胞 / 増殖因子 / 平滑筋細胞 / 組織因子 / cross-talk sianal / シグナル伝達 / センダイウイルスペクター / 抗血管新生療法 / 血管新生遺伝子治療 / PEDF / PDGFファミリー / VEGFファミリー / 血管・リンパ管新生 / 線維芽細胞増殖因子(FGF-2) / tissue stem cell / angiogenic hierarchy / ウイルスベクター / 組織幹細胞 / 血管新生因子の階層性 / critical limb ischemia / recombinant Seiidai virus vector / 嚢胞性線維症 / 慢性関節リウマチ / 網膜色素変性症 / 肺高血圧症 / レンチウイルスベクター / Vasculitis / Human cytomegalovirus / 前初期遺伝子 / 炎症性腹部大動脈瘤 / 血管炎 / ヒトサイトメガロウイルス / Decoy / Transcription Factor / Liposome / Antisense / デコイ / リポソーム / アンチセンス / therapeutic angiogenesis / safety / 移植 / SeVベクター / 血管新生療法 / 安全性 / 一酸化窒素 / renal function / coronary heart disease / alcohol / dyslipidemia / glucose intolerance / hypertension / insulin resistance / hyperinsulinemia / 飽和脂肪酸 / 疫学調査 / 食事性因子 / 予後 / 脳梗塞 / 血清脂質 / 疫学研究 / 危険因子 / 一般住民 / 前向き追跡研究 / アルコール摂取 / インスリン抵抗性症候群 / 腎機能 / 虚血性心疾患 / アルコール / 脂質代謝異常 / 耐糖能異常 / 高血圧 / インスリン抵抗性 / 高インスリン血症 / gene transfer vector / TGFβ^1 / 遺伝子導入ベクター / Atheroscrelosis / 血栓形成 / 血管内皮細胞増殖因子 / apoptosis / HVJ-lipsome method / アポトーシス / HVJ・liposome法 / Vascular endothelial growth facator / Angiogensis / Thrombosis / Athero-and arteriosclerpsis / Smooth muscle cells / ヒトCMV・IE遺伝子 / HVJ・リポゾーム / 動脈内膜障害・修復 / 血管内皮増殖因子 / IL-1ra / Tissue factor / Atherosclerosis / Thrombus / IL‐1レセプターアンタゴニスト / IL‐1 / IL-1レセプターアンタゴニスト / X-ray irradiation / serotonin / platelet / restenosis / coronary artery spasm / coronary artery stenosis / 冠動脈造影法 / ミニ豚 / 冠血行再建術 / 冠動脈硬化 / 心筋虚血 / 内皮細胞依存性血管弛緩反応 / PTcA / 内膜肥厚 / X線照射 / セロトニン / 血小板 / 再狭窄 / 冠動脈攣縮 / 冠動脈狭窄 / コラゲナーゼ / 腫瘍間質 / プラスミノゲン・アクチベーター / プラスミノゲン / 線溶 / 擬固 / 転移 / IL-17 / SIV / Sprouty-2 / 関節リウマチ / 下肢虚血 / ecNOS / TGFβ_1 / PTCA後再狭窄 / 炎症 / HVJ-リポゾーム / p53遺伝子 / Tie-2 / サイトメガロウイルス / 動脈リモデリング / 導入効率 / 肝 / 血管 / HVJ-liposome / HVJ-catinic liposome / 低酸素 / 接着斑 / 免疫組織化学 / プラスミノゲン・アクチベ-タ- Less
  • Research Projects

    (27 results)
  • Research Products

    (6 results)
  • Co-Researchers

    (25 People)
  •  新規遺伝子導入ベクターを用いた慢性関節リウマチの治療法の開発

    • Principal Investigator
      中川 和憲
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Kyushu University
  •  Hierarchical Regulation of Multiple Angiogenic Growth Factors During 'Functional' Angiogenesis In Vivo

    • Principal Investigator
      YONEMITSU Yoshikazu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Moleculo-Pathological studies on intracellular cross-talk signal in angiogenic process.

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Molecular Pathophysiological Study on Endothelial Function Occurring during Vascular Remodeling

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  動脈硬化発生・進展における血管内皮細胞機能に関する分子病理学的研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Role of human cytomegalovirus infection and the expression of immediate early gene products (CMV-IE) in the pathogenesis of vascular lesion formations

    • Principal Investigator
      YONEMITSU Yoshikazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Deveelopment of Novel Gene Theray Strategies Using Recombinant Sendai Virus.

    • Principal Investigator
      YONEMITSU Yoshikazu
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  動脈硬化発生・進展における血管内皮細胞機構に関する分子病理学的研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Patho-physiological studies on cellular interaction in vascular injury and vascular remodeling

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Regulation of Vascular Remodeling by Gene Transfer and Its Clinical Application : Exploration of Novel Gene Transfer Vector and Gene Therapy for Atherosclerosis, Angiogenic Diseases and Organ Infarction

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Trial research for practical use of the reagent for gene expression control by Decoy oligo nucleotide.

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  動脈硬化発生・進展における血管内皮細胞機能に関する分子病理学的研究

    • Principal Investigator
      据石 克夫
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Molecular pathobiological Study on Endothelial Function Ocurring during Vascular Remodeling

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Pathological and Epidemiological Study of Coronary Atherosclerosis in Autopsy Subjects of Hisayama TownPrincipal Investigator

    • Principal Investigator
      NAKASHIMA Yutaka
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  Actual state and prognosis of insulin resistanse syndrome in a general Japanese population : the Hisayama study

    • Principal Investigator
      KIYOHARA Yutaka
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Public health/Health science
    • Research Institution
      Kyushu University
  •  動脈硬化発生・進展における血管内皮細胞機能に関する分子病理学的研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Molecular pathological studies on physiological function of VEGF in atherosclerotic Vessels

    • Principal Investigator
      NAKAGAWA Kazunori
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      KYUSHU UNIVERSITY
  •  遺伝子導入ベクターの開発とin vivo応用

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Endothelial Modulation of Vascular Remodeling

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  in situ immunocytochemical study of adhesion molecules expressed on endothelium in atherosclerosis-prone mousePrincipal Investigator

    • Principal Investigator
      NAKASHIMA Yutaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Molecular Pathology of Endothelial Function in the Regulation of Vascular Response to Injuries

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  Molecular Pathological Study on Endothelial Regulation of Blood-Vascular Wall Interaction

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  血管内血管新生における内皮細胞・平滑筋細胞相互反応に関する分子病理学的研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Mechanisms of Restenosis Following Coronary Angioplasty and its Prevention

    • Principal Investigator
      TOMOIKE Hitonobu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Yamagata University School of Medicine
      Kyushu University
  •  血管壁凝固、線溶の活性化ならびに制御機構に関する分子病理学的研究

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kyushu University
  •  解離性大動脈瘤の発生機序に関する実験的研究Principal Investigator

    • Principal Investigator
      中島 豊
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyushu University
  •  癌細胞表面の擬固、線溶系活性化機構と転移形成における意義に関する研究

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University

All 2005 2004 2003 2002

All Journal Article

  • [Journal Article] Angiogenesis/lymphangiogenesis and expression of lymphangiogenic factors in atherosclerotic intima of human coronary arteries.2005

    • Author(s)
      Nakano T, Nakashima Y, Yonemitsu Y, Sumiyoshi S, Chen YX, Akishima Y, Ishii T, Iida M, Sueishi K
    • Journal Title

      Hum Pathol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Journal Article] Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.2004

    • Author(s)
      Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshit A
    • Journal Title

      Circ Res 94(3)

      Pages: 385-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Journal Article] Recombinant Sendai virus vectors for activated T lymphocytes.2003

    • Author(s)
      Okano S, Yonemitsu Y, Nagata S, Sata S, Onimaru M, Nakagawa K, Tomita Y, Kishihara K, Hashimoto S, Nakashima Y, Sugimachi K, Hasegawa M, Sueishi K
    • Journal Title

      Gene Ther 10(16)

      Pages: 1381-1391

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Journal Article] Airway-directed gene transfer of interleukin-10 using recombinant Sendai virus effectively prevents post-transplant fibrous airway obliteration in mice.2003

    • Author(s)
      Shoji F, Yonemitsu Y, Okano S, Yoshino I, Nakagawa K, Nakashima Y, Hasegawa M, Sugimachi K, Sueishi K
    • Journal Title

      Gene Ther 10(3)

      Pages: 213-218

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Journal Article] Distributions of diffuse intimal thickening in human arteries : preferential expression in atherosclerosis-prone arteries from an early age.2002

    • Author(s)
      Nakashima Y, et al.
    • Journal Title

      Virchows Arch 441(3)

      Pages: 279-288

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • [Journal Article] Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosis-prone arteries from an early age.2002

    • Author(s)
      Nakashima Y, Chen YX, Kinukawa N, Sueishi K
    • Journal Title

      Virchows Arch. 441(3)

      Pages: 279-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370078
  • 1.  SUEISHI Katsuo (70108710)
    # of Collaborated Projects: 25 results
    # of Collaborated Products: 5 results
  • 2.  NAKAGAWA Kazunori (50217668)
    # of Collaborated Projects: 21 results
    # of Collaborated Products: 2 results
  • 3.  YONEMITSU Yoshikazu (40315065)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 3 results
  • 4.  KONO Shinji (20225379)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  HASHIMOTO Shuichi (00243931)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 1 results
  • 6.  石井 寛 (10150400)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  TASHIRO Yoshihiko (10188237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KIYOHARA Yutaka (80161602)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  ISHIBASHI Hiroaki (90254630)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  TOMOIKE Hitonobu (90112333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YAMAKI Michiyasu (40191217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  IKEDA Kozue (30184419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TONOOKA Ichiro (70164001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KUBOTA Isao (30161673)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SHIROTA Tomoko (80069781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KANEDA Yasufumi (10177537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KOMORI Kimihiro (40225587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SAKAMOTO Taiji (10235179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TSUZUKI Teruhisa (40155429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  ISHIBASHI Tatsuro (30150428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  EGASHIRA Kensuke (60260379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  岡村 孝 (30136436)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  楢林 英樹 (90208083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  稲生 哲治 (10159965)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  岡部 靖彦
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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