YOKONO Koichi 横野浩一

Researcher Number	50144580
Other IDs
Affiliation (based on the past Project Information) *help	2012 – 2013: 神戸大学, その他部局等, その他 2011: 神戸大学, 理事 2011: 神戸大学, その他部局等, 理事 2008: 神戸大学, 大学院医学研究科, 教授 2007 – 2008: Kobe University, Graduate School of Medicine, Professor … More 2007: Kobe UniversityGraduate School of, Graduate School of Medical, Professor 2003 – 2007: 神戸大学, 大学院・医学系研究科, 教授 2006: 神戸大学, 大学院医学系研究科, 教授 2002: 神戸大学, 大学院・医学研究科, 教授 1995: 神戸大学, 医学部, 助教授 1994: Kobe University School of Medicine, Reader in Biochemistry, 医学部・府属病院, 講師 1992 – 1994: 神戸大学, 医学部・附属病院, 講師 1992 – 1993: 神戸大学, 医学部附属病院, 講師 1986 – 1991: 神戸大学, 医学部附属病院, 助手 1990: 神戸大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 Except Principal Investigator 内分泌・代謝学 / Metabolomics / Pathological medical chemistry / Applied health science / Digestive surgery / 内科学一般 / Integrated Nutrition Science / General internal medicine (including Psychosomatic medicine) / Cerebral neurosurgery
Keywords	Principal Investigator インスリン依存型糖尿病 / 自己免疫疾患 / NODマウス / RT-PCR / サイトカイン / CD4陽性T細胞 / 膵ラ島炎 / 免疫不全マウス / T細胞 / 自己免疫 … More / Th_1とTh_2細胞 / チロシンフォスファターゼ / CD45アイソフォーム / ELISA / モノクロ-ナル抗体 / インスリン抵抗性 / インスリン受容体 / 糖尿液 / サプレッサ-Tリンパ球 / 活性化Tリンパ球 / モノクロナル抗体 / インタ-ロイキン2受容体 / インタ-ロイキン2 / I型糖尿病 … More Except Principal Investigator 1型糖尿病 / mTOR / NODマウス / NOD mouse / 免疫寛容 / CD11c / 自己免疫 / Type 1 diabetes / ADL / I型糖尿病 / インスリン / 樹状細胞 / 栄養センサー / 接着分子 / インスリン依存型糖尿病 / PI3-キナーゼ / 糖尿病 / インスリン受容体 / Interleukin 2 / Activated macrophages / Anti-islet cell surface antibodies / Type I diabetes / マクロファージ / Tリンパ球 / 免疫抑制療法 / 単クローン性抗体 / 細胞傷害性Tリンパ球 / サプレッサーTリンパ球 / ヘルパーTリンパ球 / 膵ラ島炎 / 自己免疫疾患 / サプレッサーT細胞 / インターロイキン2 / 活性化マクロファージ / 膵ラ島細胞膜抗体 / immune tolerance / regulatory T cell / cytokine / regulatory dendritic cell / bone marrow cell / autoimmunity / type 1 diabetes / 調節性T細胞 / サイトカイン / 制御性樹状細胞 / 骨髄細胞 / autoreactive T cell / insulin / 自己反応性T細胞 / Dendritic cells / Pioglitazone / Thiazolidine derivative / 液体食事負荷試験 / チアゾリン誘導体 / NKT細胞 / 緩徐進行型1型糖尿病 / ピオグリタゾン / ピオグルタゾン / チアゾリジン誘導体 / Nutrition Sensor / Energy Metabolism / Signal Transduction / 癌 / エネルギー代謝 / シグナル伝達 / cognitive function / cardioyascular disease / excerise / metebolic syndrome / elderly / 万歩計 / 近赤外分光法 / 脳機能 / 動機付け / 運動療法 / メタボリック症候群 / 認知機能 / 生活機能障害 / 心血管病変 / 運動 / メタボリックシンドローム / 高齢者 / islet culture / two-layer method / warm ischemic time / non-heart beating donor / islet translation / 膵島培養 / 二層法 / 温阻血障害 / 心停止ドナー / 膵島移植 / Immunological tolerane / Adhesion Molecules / IDDM / active suppression / Scidマウス / NOD / 免疫寛容誘導 / 発症予防 / 細胞間接着分子 / NOD-scid / 受身移入 / VLA-4 / VCAM-1 / LFA-1 / ICAM-1 / 免疫学的寛容誘導 / PI 3-kinase / GLUT / Insulin / 膜ラッフル形成 / 糖輸送担体 / glucose transporter gene / IRS-1 gene / mitochondrial gene / glucokinase gene / insulin receptor gene / インスリン受容体異常症 / NIDDM / 糖輸送担体遺伝子 / IRS-1遺伝子 / ミトコンドリア遺伝子 / グルコキナーゼ遺伝子 / インスリン夛容体遺伝子 / モノクロナル抗体 / 燐酸化チロシン / phosphotyramine / I型Pエキナ-ゼ活性 / Vーabl / 代謝 / 分子栄養 / 分子栄養学 / 糖・エネルギー代謝 / 病原体感知センサー / １型糖尿病 / 細胞内シグナル / 分子病態栄養学 / 中大脳動脈閉塞 / 脳血管撮影 / ラット / 脳動脈瘤 / 高輝度放射光 / T細胞ハイブリドーマ / 膵ラ島反応性CD4陽性T細胞 / SHC / SH-2ドメイン / IRS-1 / EGF受容体 / MAPキナ-ゼ / IRSーI / GAP / PIー3キナ-ゼ / ラットインスリン遺伝子 / アンチセンスDNA / インスリン遺伝子 / トランスジェニックマウス / cーRafー1 / PDGF受容体 Less

The role of dsRNA sensor in dendritic cells in a tolerized model of Type 1 diabetes
- Principal Investigator
  
  YASUDA HISAFUMI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kobe University
栄養感知システムmTORシグナルの分子基盤の解明と分子栄養学への展開
- Principal Investigator
  
  原賢太
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Kobe University
Regulation of mTOR-mediated nutrition sensing system
- Principal Investigator
  
  HARA Kenta
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Prediction of human type 1 diabetes and preventive immune cell therapy using dendritic cells
- Principal Investigator
  
  YASUDA Hisafumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Preventative effects of exercise on the cardiovascular disease, ADL and cognitive function of the elderly with metabolic syndrome
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kobe University
Physiological role and molecular mechanism of mTOR signaling as a sensor of nutrition
- Principal Investigator
  
  HARA Kenta
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Research of prevention of type 1 diabetes by thiazolidine derivative.
- Principal Investigator
  
  NAGATA Masao
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Research of autoreactive Tcells to insulin as a major autoantigen in type 1 diabetes
- Principal Investigator
  
  MORIYAMA Hiroaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kobe University
Reserch of Clinical islet transplantation from non-heart beating donor using 2-step two-layer method
- Principal Investigator
  
  KURODA Yoshikazu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University
高輝度放射光(SPring-8)を用いた実験的脳動脈瘤及び脳新生血管の動態解析
- Principal Investigator
  
  近藤威, 山下晴央
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kobe University
インスリン依存型糖尿液におけるTh_1細胞とTh_2細胞の相互作用Principal Investigator
- Principal Investigator
  
  横野浩一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
免疫不全マウス(Scidマウス)におけるインスリン依存型糖尿病の発現と病因回析Principal Investigator
- Principal Investigator
  
  横野浩一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
インスリン依存型糖尿病における病因関連T細胞上のCD45分子の機能的解析Principal Investigator
- Principal Investigator
  
  横野浩一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
Studies on the molecular basis of insulin actions
- Principal Investigator
  
  KASUGA Masato
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kobe University
Induction of Tolerance in Murine Autoimmune Diabetes by Transient Blockade of LFA-1/ICAM-1 Pathway
- Principal Investigator
  
  AMANO Kazuhiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
受容体型チロシンキナーゼを介する情報伝達機構
- Principal Investigator
  
  春日雅人
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
膵ラ島由来、CD4陽性T細胞を用いた膵β細胞特異反応性T細胞ハイブリドーマの作製
- Principal Investigator
  
  AMANO Kazuhiko
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
Role of gene mutations in development of diabetes mellitus
- Principal Investigator
  
  KASUGA Masato
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
受容体型チロシンキナ-ゼを介する情報伝達機構
- Principal Investigator
  
  春日雅人
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
モノクロ-ナル抗体を用いたインスリン受容体チロシンキナ-ゼ測定系の開発Principal Investigator
- Principal Investigator
  
  横野浩一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
増殖因子受容体形チロシンキナ-ゼを介する情報伝達機構の解明
- Principal Investigator
  
  KASUGA Masato
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
トランジェニックマウスを用いた糖尿病の成因の解析
- Principal Investigator
  
  春日雅人
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
I型糖尿病発症機構における細胞性免疫異常,とくにインタ-ロイキン2受容体の解析Principal Investigator
- Principal Investigator
  
  横野浩一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University
燐酸化チロシンに対する特異的モノクロ-ナル抗体の開発と量変化ー腫瘍の診断ならびに情報伝達機構の解明のためにー
- Principal Investigator
  
  春日雅人
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  Kobe University
  The University of Tokyo
Studies on Pathogenesis and Prevention of Type I Diabetes Mellitus using Monoclonal Anti-Islet Cell Surface Antibodies.
- Principal Investigator
  
  BABA Shigeaki
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kobe University

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All Journal Article Presentation Book

[Book] 【最新臨床糖尿病学　下-糖尿病学の最新動向-】ライフステージ・タイプ別糖尿病の病態と治療　高齢者糖尿病　認知機能障害を有する高齢者糖尿病の管理のあり方2012
- Author(s)
  横野浩一, 安田尚史
- Total Pages
  4
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-23590880
[Book] 【浮腫の鑑別・対処法・メカニズム】薬剤性浮腫2012
- Author(s)
  安田尚史, 横野浩一
- Total Pages
  8
- Publisher
  Fluid Management Renaissance
- Data Source
  KAKENHI-PROJECT-23590880
[Book] 【高齢者糖尿病と認知症-糖尿病ケアにおける問題点-】糖尿病患者における認知症の対応　現状と将来への展望2012
- Author(s)
  横野浩一、安田尚史
- Total Pages
  7
- Publisher
  プラクティス
- Data Source
  KAKENHI-PROJECT-23590880
[Book] ブリットル糖尿病の病態と治療・管理のコツ　－進化する治療・広がる未来ー2012
- Author(s)
  安田尚史、横野浩一
- Total Pages
  7
- Publisher
  別冊プラクティス
- Data Source
  KAKENHI-PROJECT-23590880
[Book] 注意を要するインスリン依存状態の治療, 高齢1型糖尿病の管理, 別冊プラクティスブリットル糖尿病の病態と治療・管理のコツ-進化する治療・広がる未来-2012
- Author(s)
  安田尚史、横野浩一
- Data Source
  KAKENHI-PROJECT-23590880
[Book] 【高齢者の糖尿病管理】高齢者糖尿病の臨床的特徴2011
- Author(s)
  安田尚史、横野浩一
- Total Pages
  8
- Publisher
  月刊糖尿病
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination: a case report.2012
- Author(s)
  Yasuda H, Nagata M, Moriyama H, Kobayashi H, Akisaki T, Ueda H, Hara K, Yokono K.
- Journal Title
  
  Diabet Med.
  
  Volume: 29 Issue: 1 Pages: 88-89
- DOI
  10.1111/j.1464-5491.2011.03391.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acid.2012
- Author(s)
  Nakamura A, Hara K, Yamamoto K, Yasuda H, Moriyama H, Hirai M, Nagata M, Yokono K
- Journal Title
  
  Geriatr Gerontol Int.
  
  Volume: 12 Issue: 1 Pages: 131-139
- DOI
  10.1111/j.1447-0594.2011.00729.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events2012
- Author(s)
  Hara K, Yasuda H, Arai T, Miyoshi S, Kubokawa O, Mori H, Akisaki T, Kido Y, Yokono K, Akita H
- Journal Title
  
  Intern Med
  
  Volume: 51(9) Pages: 1065-8
- NAID
  130002061802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Development of fulminant Type 1 diabetes with thrombocytopenia after influenza vaccination : a case report2012
- Author(s)
  Yasuda H, Nagata M, Moriyama H, Kobayashi H, Akisaki T, Ueda H, Hara K, Yokono K
- Journal Title
  
  Diabet Med
  
  Volume: 29(1) Pages: 88-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Role of the mTOR complex 1 pathway in the in vivo maintenance of the intestinal mucosa by oral intake of amino acids.2011
- Author(s)
  Nakamaura. A., Hara K., Yamamoto K., Yasuda H., Moriyama H., Hirai M., Nagata M., Yokono K.
- Journal Title
  
  Geriatr. Geriatol. Int.
  
  Volume: 12: Pages: 131-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.2011
- Author(s)
  Sasaki H, Yasuda H, Moriyama H, Nakamura A, Shimizu M, Arai T, Nagata M, Hara K, Yokono K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 408 Pages: 306-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23617012
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation2011
- Author(s)
  Sasaki, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 408 Issue: 2 Pages: 306-311
- DOI
  10.1016/j.bbrc.2011.04.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890112, KAKENHI-PROJECT-23590880, KAKENHI-PROJECT-23890114
[Journal Article] IL-10-Conditioned Dendritic Cells Prevent Autoimmune Diabetes in NOD and HumanizedHLA-DQ8/RIP-B7.1 Mice.2011
- Author(s)
  Tai N, Yasuda H, Xiang Y, Zhang L, Rodriguez-Pinto D, Yokono K, Sherwin R, Wong FS, Nagata M, Wen L.
- Journal Title
  
  Clin Immunol.
  
  Volume: 139 Issue: 3 Pages: 336-349
- DOI
  10.1016/j.clim.2011.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Acceleration of autoimmune diabetes in Rheb-congenic NOD mice withβ-cell-specific mTORC1 activation2011
- Author(s)
  Sasaki H, Yasuda H, Moriyama H, Nakamura A, Shimizu M, Arai T, Nagata M, Hara K, Yokono K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 408(2) Pages: 306-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice2011
- Author(s)
  Tai N, Yasuda H, Zhang L, Rodriguez-Pinto D, Yokono K, Wong FS, Sherwin R, Nagata M, Wen L
- Journal Title
  
  Clin Immunol
  
  Volume: 139(3) Pages: 336-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590880
[Journal Article] Upregulation of the mTOR Complex 1 Pathway by Rheb in Pancreatic β Cells Leads to Increased β Cell Mass and Prevention of Hyperglycemia.2009
- Author(s)
  Hamada S., Hara K., Hamada T., Yasuda H., Moriyama H., Nakayama R., Nagata M., Yokono K.
- Journal Title
  
  Diabetes. 58
  
  Pages: 1321-1332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Autoreactive T cell response in CD25 negative fraction of peripheral blood mononuclear cells from establishedtype 1 diabetes2008
- Author(s)
  Morivama, H, Kotani, R, Katsuta, A, Kameno, M, Arai, T, Okumachi, Y, Kishi, M, Yamada, K, Yasuda, H, Hara, K, Yokono, K, Nagata M
- Journal Title
  
  Ann N Y Acad Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules2008
- Author(s)
  Sakata, M, Yasuda, H, Moriyama, H, Yamada, K, Kotani, R, Kurohara, M, Okumachi, Y, Kishi, M, Arai, T, Hara, K, Hamada, H, Yokono, K, Nagata, M
- Journal Title
  
  Diabetes Res Clin Pract 80(3)
  
  Pages: 352-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590931
[Journal Article] Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulationg molecules.2008
- Author(s)
  Sakata M., Yasuda H., Moriyama K., Yamada K., Kotani R., Kurohara M., Okumachi Y., Kishi M., Arai T., Hara K., Hamada H., Yokono K., Nagata M.
- Journal Title
  
  Diabetes Res.Clin.Pract. 80
  
  Pages: 352-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] One amino acid difference is critical for suppression for the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulin:9-23 peptide.2008
- Author(s)
  Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi M., Kurohara M., Yamada K., Yasuda H., Hara K., Yokono K. Nagata M.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 374
  
  Pages: 581-586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Intravenous Aministration of Murine Proinsulin I or 2 Expressing Fiber-mutant Recombinant Adenovirous Vector Protects Diabetes in NOD mice2008
- Author(s)
  Yamada, K, Morivama, H, Okumachi, Y, Arai, T, Kameno, M, Kishi, M, Yasuda, H, Hara, K, Yokono, K, Naeata, M
- Journal Title
  
  A nn N Y Acad Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Modification of the Rb-binding Domain of Replication-Competent Adenovirus Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-kB Activity2007
- Author(s)
  Yamada, K, Moriyama, H, Yasuda, H, Hara, K, Maniwa, Y, Hamada, H, Koichi, Yokono, Nagata, M
- Journal Title
  
  Hum Gene Ther 18(5)
  
  Pages: 389-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590931
[Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice2007
- Author(s)
  Moriyama, H., Nagata, M., T., Arai, Y., Okumachi, K., Yamada, R., Kotani, H., Yasuda, K., Hata, K, Yokono
- Journal Title
  
  Diabetes Res Clin Pract S155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590931
[Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knouckout NOD mice.2007
- Author(s)
  Moriyama H., Nagata M., Arai T., Okumachi Y., Yamada K., Kotani R., Yasuda H., Hara K., Yokono K.
- Journal Title
  
  Diabetes Res.Clin.Pract. 77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Immunological aspects of'fulminant type 1 diabetes2007
- Author(s)
  Nagata, M, Morivama, H, Kotani, R, Yasuda, H, Kishi, M, Kurohara, M., Hara, K, Yokono, K
- Journal Title
  
  Diabetes Res Clin Pract
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Immunological aspects of `fulminant type 1 diabetes'2007
- Author(s)
  Nagata, M, H. Moriyama, R. Kotani, H. Yasuda, M. Kishi, M. Kurohara, K. Hara, K. Yokono
- Journal Title
  
  Diabetes Res Clin Pract S99-S103
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590931
[Journal Article] Modification of the Rb-binding domain of replication-competent adenoviral vector enhances cytotoxicity against human esophageal cancers via NF-kappaB activity2007
- Author(s)
  Yamada, K, Moriyama, H, Yasuda, H, Hara, IC, Maniwa, Y, Hamada, H, Yokono, K, Napata, M
- Journal Title
  
  Hum Gene Ther 18(5)
  
  Pages: 389-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.2007
- Author(s)
  Zhou J., Hara K., Inoue M., Hamada S., Yasuda H., Moriyama H., Endo H., Hirota K., Yonezawa K., Nagata M., Yokono K.
- Journal Title
  
  Kobe J. Med. Sci 53
  
  Pages: 283-296
- NAID
  110006646896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Modification of the Rb-binding Domain of Replication- Competent Adenovirus Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-kB Activity.2007
- Author(s)
  Yamada K., Moriyama H., Yasuda H., Hara K., Maniwa Y., Hamada H., Yokono K., Nagata M.
- Journal Title
  
  Human Gene Therapy 2007 18
  
  Pages: 389-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice2007
- Author(s)
  Morivama, H, Nagata, M., Arai, T, Okumachi, Y, Yamada, K, Kotani, R, Yasuda, H, Hara, K, Yokono, K
- Journal Title
  
  Diabetes Res Clin Pract 23:77S
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] A possible association of ProI2Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia2005
- Author(s)
  Danawati, C. W., Nagata, M., Moriyama, H., Hara, K., Yasuda, H., Nakayama, M., Kotani, R., Yamada, K., Sakata, M., Kurohara, M., Wiyono, P., Asdie, H., Sakaue, M., Taniguchi, H., Yokono. K
- Journal Title
  
  Diabetes Metab Res 21
  
  Pages: 465-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes.
- Author(s)
  Nagata M., Moriyama H., Kotani R., Yasuda H., Kishi M., Kurohara M., Hara K., Yokono K.
- Journal Title
  
  Diabetes Res. Clin. Pract.
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590308
[Journal Article] Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes
- Author(s)
  Kurohara, M, Yasuda, H, Moriyama, H, Sakata, M, Yamada, K, Kotani, R, Nakayama, M, Hara, K, Yokono, K, Nagata, M
- Journal Title
  
  Kobe J. Med. Sci (in press)
- NAID
  110006648210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590931
[Presentation] １型糖尿病関連マウスにおけるpoly(I:C)投与による１型糖尿病発症の検討2013
- Author(s)
  清水まみ、安田尚史、勝田敦美、高橋和真、原賢太、永田正男、横野浩一
- Organizer
  第11回１型糖尿病研究会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] FasL-Fasシグナルの1型糖尿病発症における役割の検討2013
- Author(s)
  安田尚史、勝田敦美、清水まみ、佐々木弘智、原賢太、秋田穂束、横野浩一
- Organizer
  第8回加齢医学研究会
- Place of Presentation
  名古屋
- Year and Date
  2013-01-19
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 1型糖尿病関連マウスにおけるpoly(I : C)投与による1型糖尿病発症の検討2013
- Author(s)
  清水まみ、安田尚史、勝田敦美、高橋和真、原賢太、永田正男、横野浩一
- Organizer
  第11回1型糖尿病研究会
- Place of Presentation
  軽井沢
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] Modified LDLがリガンドであるSR-Aの1型糖尿病発症への影響2012
- Author(s)
  清水まみ、安田尚史、中村晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第7回加齢医学研究会
- Place of Presentation
  名古屋
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] NODマウスにおける1型糖尿病発症に関連するSR-Aの役割の検討2012
- Author(s)
  清水まみ、安田尚史、勝田敦美、中村晃、佐々木弘智、永田正男、原賢太、高橋和真、横野浩一
- Organizer
  第10回1型糖尿病研究会
- Place of Presentation
  唐津
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] poly(I : C)投与SR-A KO NODマウスでの1型糖尿病発症の検討2012
- Author(s)
  清水まみ、安田尚史、中村晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原賢太、高橋和眞、横野浩一
- Organizer
  第55回日本糖尿病学会総会
- Place of Presentation
  横浜
- Year and Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] poly(I:C)投与SR-A KO NODマウスでの1型糖尿病発症の検討2012
- Author(s)
  清水まみ、安田尚史、中村　晃、勝田敦美、佐々木弘智、荒井隆志、永田正男、原　賢太、高橋和真、横野浩一
- Organizer
  第55回日本糖尿病学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 膵β細胞特異的Rheb過剰発現NODマウスにおける1型糖尿病発症の検討2011
- Author(s)
  佐々木弘智、安田尚史、森山啓明、清水まみ、中村晃、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23617012
[Presentation] 膵β細胞特異的Rheb過剰発現NODマウスにおける1型糖尿病発症の検討2011
- Author(s)
  佐々木弘智、安田尚史、森山啓明、清水まみ、中村晃、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第54回日本糖尿病学会総会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] 1型糖尿病発症におけるMSR-Aの役割の検討2011
- Author(s)
  清水まみ、安田尚史、森山啓明、中村晃、勝田敦美、花野智苗、佐々木弘智、荒井隆志、永田正男、原賢太、横野浩一
- Organizer
  第9回1型糖尿病研究会
- Place of Presentation
  大磯
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23590880
[Presentation] Upregulation of mTORC1 pathway by Rheb in pancreatic βcells leads to increased β cell mass and prevention of hyperglycemia. 68th Scientific Sessions2008
- Author(s)
  Kenta Hara, Suirin Hamada, Akira Nakamura, Hisafumi Yasuda, Hiroaki Moriyama, Masao Nagata, Koichi Yokono
- Organizer
  The American Diabetes Association
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] 膵β細胞におけるmTORシグナルの活性化と糖尿病発症の抑制2008
- Author(s)
  濱田水鈴、原賢太、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第50回日本老年医学会学術集会・総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] mTORシグナルのRhebによる活性化は膵β細胞の成長を促し高血糖を抑制する2008
- Author(s)
  濱田水鈴、原賢太、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] RhebによるmTORC1経路の活性化は膵β細胞の成長を促し高血糖を抑制する2007
- Author(s)
  原賢太、濱田水鈴、濱田猛、中村晃、安田尚史、森山啓明、永田正男、横野浩一
- Organizer
  第19回分子糖尿病学シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19590308
[Presentation] Autoreactive T cell responses in CD25 negative fraction of peripheral blood mononuclear cells from established type 1 diabetes2007
- Author(s)
  Morivama, H., Kotani, R., Kameno, M., Arai, T, Okumachi, Y., Kishi, M., Kurohara, M, Yasuda, H., Yamada, K., Yokono, K, Nagata M
- Organizer
  the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Intervenous administration of murine proinsulinl or 2 expressing recombinant adenovirus vector protects from diabetes in NOD mice. Acta Diabetologia Vol. 44, S56 Poster presentation at the 9'" International Congress of the immunology of Diabetes Society and American Diabetes Association Research Symposium at Miami, November 20072007
- Author(s)
  Yamada, K., Morivama, H., Arai, T, Kameno, M., Okumachi, Y, Kishi, M., Kurohara, M, Yasuda, H., Yokono, K, Napata, M
- Organizer
  the 9°th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] One amino acid difference of insulin:9-23 peptides critically influence on the effect of deletional therapy for experimental autoimmune diabetes (EAD). Acta Diabetologia Vol. 44, S36 Poster presentation at the 9°i International Congress of the immunology of Diabetes Society and American Diabetes Association Research Symposium at Miami, November 20072007
- Author(s)
  Okumachi, Y., Moriyama, H., Kameno, M., Arai, T, Kishi, M., Kurohara, M, Yamada, K., Yasuda, H., Yokono, K., Nagata, M
- Organizer
  the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
- Place of Presentation
  Miami, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Intravenous Administration of Insulinl B9-23 Peptide Reduces T Cell Reactivity to Insulin and Protects Autoimmune Diabetes in Experimental Autoimmune Diabetes2006
- Author(s)
  Okumachi, Y, Morivama, H., Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Kotani, R., Yasuda, H., Hara, K., Yokono, K., Nagata, M
- Organizer
  the 66th American Diabetes Association (ADA) meeting
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Subcutaneous transplantation with Proinsulin2 expressing fibroblasts protects diabetes in NOD mice2006
- Author(s)
  Yamada, K., Moriyama, H., Okumachi, Y, Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Hara, K, Yokono, K., Nagata, M
- Organizer
  the 66th American Diabetes Association (ADA) meeting
- Place of Presentation
  Washington DC, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932
[Presentation] Insulin reactive T cells in EAD(Exprimental Autoimmune Diabetes) Model2005
- Author(s)
  Moriyama, H, Nagata, M, Kotani, R, Okumachi, Y, Arai, T, Yamada, K, Yasuda, H, Eisenbarth, GS, Yokono, K
- Organizer
  the 8th Meeting of the Immunology of Diabetes Society (IDS-8)
- Place of Presentation
  Awaji Island
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590932

1. KASUGA Masato (50161047)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. HARA Kenta (70397826)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
3. AMANO Kazuhiko (20231988)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. NAGATA Masao (70294220)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
5. MORIYAMA Hiroaki (70372646)

# of Collaborated Projects: 5 results

# of Collaborated Products: 21 results
6. YASUDA Hisafumi (50403233)

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# of Collaborated Products: 36 results
7. SAKURAI Takashi (50335444)

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8. 門脇孝 (30185889)

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9. 近藤威 (50273769)

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10. 明嵜太一 (80467662)

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11. 志伊光瑞

# of Collaborated Projects: 2 results

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12. AOYAMA Nobuo (30243299)

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13. KURODA Yoshikazu (70178143)

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19. TAKAHASHI Kazuma (60292215)

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20. KAWAMURA Tomoyuki (60271186)

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21. BABA Shigeaki (10030818)

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23. 山下晴央 (10183683)

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24. 江原一雅 (20151996)

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25. 甲村英二 (30225388)

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26. 森茂郎 (30010424)

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27. 高久史磨 (40048955)

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28. 泉哲郎 (00212952)

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30. HOLMAN Geoffrey d.

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31. 吉村昌治

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32. 杉正人

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33. 浜冲勝

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34. 浜沖勝

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35. 岸本美也子

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36. WATERFIELD M

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37. WATERFIELD Michel d.

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YOKONO Koichi 横野 浩一

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インスリン依存型糖尿液におけるTh_1細胞とTh_2細胞の相互作用Principal Investigator

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免疫不全マウス(Scidマウス)におけるインスリン依存型糖尿病の発現と病因回析Principal Investigator

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インスリン依存型糖尿病における病因関連T細胞上のCD45分子の機能的解析Principal Investigator

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YOKONO Koichi 横野浩一