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AOYAMA Nobuo  青山 伸郎

ORCIDConnect your ORCID iD *help
… Alternative Names

青山 伸朗  アオヤマ ノブオ

青山 信郎  アオヤマ ノブオ

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Researcher Number 30243299
Affiliation (based on the past Project Information) *help 2002 – 2004: Kobe Univ.University Hospital Associate Professor, 医学部附属病院, 助教授
2003: Kobe University School of Medicine, Kobe University Hospital, Associate Professor, 医学部付属病院, 助教授
1998 – 2001: Kobe University School of Medicine, Assocaite Professor, 医学部・附属病院, 助教授
1998: 神戸大学, 医学部附属病院, 助教授
1992 – 1997: 神戸大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology
Except Principal Investigator
Gastroenterology / 応用薬理学・医療系薬学 / Bacteriology (including Mycology) / 内分泌・代謝学 / Medical pharmacy
Keywords
Principal Investigator
apoptosis / p53 / p53遺伝子 / アポトーシス / RER / 大腸癌 / MDR / replication error / colorectal carcinoma / multidrug resistance … More
Except Principal Investigator
… More 消化器癌 / チロシンホスファターゼ / SAP-1 / MDR1 / CEA / Gastrointestinal cancer / HDC / PTPH1 / CYP2C19 / ヘリコバクター / 空胞化毒素 / VacA毒素 / 毒性発現 / 細菌毒素 / ヘリコバクター・ピロリ / VacA / vacuolating cytotoxin / VacA toxin / bacterial toxin / Caco-2 / mRNA / CYP3A / Ras / 増殖因子 / SHP-2 / SHPS-1 / キロシンホスファターゼ / インスリン夛容体遺伝子 / グルコキナーゼ遺伝子 / ミトコンドリア遺伝子 / IRS-1遺伝子 / 糖輸送担体遺伝子 / NIDDM / インスリン受容体異常症 / insulin receptor gene / glucokinase gene / mitochondrial gene / IRS-1 gene / glucose transporter gene / テロシンホスファターゼ / 抗体 / 阻害剤 / チロシンガスファターゼ / モノクローナル抗体 / 腫瘍マーカー / Protein tyrosine phosphatse / Antibody / Inhibitor / ガストリン / ヒスタミン / 胃粘膜 / 分化 / 増殖 / 被蓋上皮細胞 / 分化-増殖 / トランスジェニックマウス / 胃粘膜上皮細胞 / gastrin / histamine / DTPHI / 細胞接着 / Ezrin / Protein tyrosine phosphatase / Cell adhesion / 遺伝子型 / オメプラゾール / ランソプラゾール / ピロリ / 除菌治療 / 薬物血中濃度 / 胃内pHモニタリング / 胃内pHモンタリング / オメプラゾ-ル / ランソプラゾ-ル / 胃内PHモニタリング / genotype / omeprazole / lansoprazole / Helicobacter pylori / anti-H.pylori therapy / plasma concentration / gastric pH monitoring / ワクチン / 成分ワクチン / CagPAI / ワクチン開発 / 病原遺伝子群 / Helicobacier pylori / toxicity / vaccine / 十二指腸上皮細胞 / リアルタイムPCR / MRP / ヒト十二指腸上皮細胞 / Human duodenal enterocytes / Real time PCR / MRP1 / 多様な疾患 / 多形比較 / ヘリコバクター・ピロリ感染症 / Helicobocter pylori / diseases / Toxin comparison / 薬物輸送担体 / トランスポーター / 遺伝子 / 遺伝子診断 / ファーマコゲノミクス / ファーマコジェネティクス / シクロスポリン / MDRI / ファーマコジュネティクス / ジゴキシン / Drug transporters / Gene / Genotyping / Pharmacogenomics / Pharmacogenetics / Digixin / Cyclosporine Less
  • Research Projects

    (13 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (21 People)
  •  Order-made pharmacotherapy based on MDR1 genotyping

    • Principal Investigator
      SAKAEDA Toshiyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kobe University
  •  Research for comparison of VacA in H. pylori infectious diseases

    • Principal Investigator
      HIRAYAMA Toshiya
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Nagasaki University
  •  Basic research for H. pylori component vaccine

    • Principal Investigator
      HITAYAMA Toshiya
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Nagasaki University
  •  Real time PCR analysis of transporter and metabolism enzyme expression level in human alimentary canal epidermic cell

    • Principal Investigator
      SAKAEDA Toshiyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KOBE UNIVERSITY
  •  Role of Cytochrome P450 2C19 Genotypes in Anti-Helicobacter Pylori Therapy with Proton Pump Inhibitors

    • Principal Investigator
      SAKAEDA Toshiyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kobe University
  •  Gastrin controls growth and differentiation of mouse gastric pit cells.

    • Principal Investigator
      KONDA Yoshitaka
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      KYOTO UNIVERSITY
      Gunma University
  •  Research for a protein tyrosine phosphatase for cell adhesion and its mutations in gastrointestinal cancers.

    • Principal Investigator
      MATOZAKI Takashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University
  •  Ras活性化機構におけるチロシンホスファターゼの機能に関する研究

    • Principal Investigator
      的崎 尚
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  大腸癌に高発現するチロシンホスファターゼSAP-1の生理機能に関する研究

    • Principal Investigator
      的崎 尚
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University
  •  Basic research and clinical application of SAP-1, a protein tyrosine phosphatase expressed in gastrointestinal cancers.

    • Principal Investigator
      MATOZAKI Takashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University
  •  Mechanism of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells (WiDr)Principal Investigator

    • Principal Investigator
      AOYAMA Nobuo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University
  •  消化器癌におけるチロシンホスファターゼの癌性変異に関する研究

    • Principal Investigator
      MATOZAKI Takashi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kobe University
  •  Role of gene mutations in development of diabetes mellitus

    • Principal Investigator
      KASUGA Masato
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kobe University

All 2003 2002 2001

All Journal Article

  • [Journal Article] MDR1 genotype-related duodenal absorption rate of digoxin in healthy Japanese subjects2003

    • Author(s)
      Y.Morita, T.Sakaeda, M.Horinouchi, T.Nakamura, K.Kuroda, I.Miki, K.Yoshimura, T.Sakai, D.Shirasaka, N.Aoyama, M.Kasuga, K.Okumura
    • Journal Title

      Pharm.Res.(PMID: 12739761) 20(4)

      Pages: 552-556

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590130
  • [Journal Article] Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677 : functional relevance to pharmacokinetics of digoxin2002

    • Author(s)
      M.Horinouchi, T.Sakaeda, T.Nakamura, Y.Morita, T.Tamura, N.Aoyama, M.Kasuga, K.Okumura
    • Journal Title

      Pharm.Res.(PMID: 12425480) 19(10)

      Pages: 1581-1585

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590130
  • [Journal Article] Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects2002

    • Author(s)
      T.Nakamura, T.Sakaeda, M.Horinouchi, T.Tamura, N.Aoyama, T.Shirakawa, M.Matsuo, M.Kasuga, K.Okumura
    • Journal Title

      Clin.Pharmacol.Ther. (PMID: 11956513) 71(4)

      Pages: 297-303

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590130
  • [Journal Article] Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects2002

    • Author(s)
      Y.Moriya, T.Nakamura, M.Horinouchi, T.Sakaeda, T.Tamura, N.Aoyama, T.Shirakawa, A.Gotoh, S.Fujimoto, M.Matsuo, M.Kasuga, K.Okumura
    • Journal Title

      Biol.Pharm.Bull(PMID: 12392094) 25(10)

      Pages: 1356-1359

    • NAID

      110003638910

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590130
  • [Journal Article] MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects2001

    • Author(s)
      T.Sakaeda, T.Nakamura, M.Horinouchi, M.Kakumoto, N.Ohmoto, T.Sakai, Y.Morita, T.Tamura, N.Aoyama, M.Hirai, M.Kasuga, K.Okumura
    • Journal Title

      Pharm.Res.(PMID: 11697464) 18(10)

      Pages: 1400-1404

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590130
  • 1.  MATOZAKI Takashi (80252782)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  SAKAEDA Toshiyuki (00304098)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  OKUMURA Katsuhiko (60025707)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 4.  HITAYAMA Toshiya (50050696)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  HAYASHI Yoshitaka (50189669)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  WADA Akihiro (70253698)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KASUGA Masato (50161047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YOKONO Koichi (50144580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TAKAHASHI Rei (60144565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  MAEDA Sakan (50030911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KITAGAWA Motoji (80262898)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAKEYAMA Yoshifumi (70263374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KONDA Yoshitaka (90261867)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TAKEUCHI Toshiyuki (00109977)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  CHIBA Tsutomu (30188487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MAKINO Souichi (30181621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YAHIRO Kinnosuke (80345024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KURAZONO Hisao (90186487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NAKAJIMA Motoo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SHIRASAKA Daisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  岸本 美也子
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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