ITO Yoshihisa 伊藤芳久

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ITO Yosehisa 伊藤芳久

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Researcher Number	50151551
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2017: 日本大学, 薬学部, 教授 2010 – 2013: 日本大学, 薬学部, 教授 2005 – 2006: 日本大学, 薬学部, 教授 2000 – 2001: 日本大学, 薬学部, 助教授 1997 – 1998: 日本大学, 薬学部, 講師 1991 – 1994: Nihon Univ. Coll. of Pharmacy, Assistant Professor, 薬学部, 専任講師 1990: 日本大学, 理工学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Pharmacology in pharmacy / 応用薬理学・医療系薬学 / Applied pharmacology Except Principal Investigator Biological pharmacy / Surgical dentistry / Applied pharmacology
Keywords	Principal Investigator 4-hydroxynonenal / s-allyl-L-cysteine / amyloid β-protein / PGE2 / 運動ニューロン / 細胞毒性 / ナノ粒子 / PGE2受容体 / パッチクランプ法 / ナノグラフェン … More / 突起進展 / 細胞分化 / ALS / 神経突起 / グラフェン / spinal cord / hippocampus / cultured neurons / neuronal death / s-allylcysteine / アミロイドβタンパク質 / PC12細胞 / caspase / 細胞死 / HNE / 切片培養 / 脊髄 / 海馬 / 培養ニューロン / 神経細胞死 / DNA-binding activity / spikeamd wave discharges / Stargazer mice / Lethargic Mice / GABA_B receptor / Absence seizures / activator protein 1 DNA / cyclic AMP responsive element / lethargicマウス / stargazerマウス / GABA_B拮抗薬 / エトクスシミド / 棘徐波複合 / 視床 / CGP 46381 / Activator protein 1 / Cyclic AMP responsive element / 欠神発作 / DNA結合活性 / 棘徐波複合放電 / Stargazerマウス / Lethargicマウス / GABA_B受容体 / てんかん欠神発作 / pentylenetetrazole / ethanol / imidazobenzodiazepines / Ro 15-4513 / benzodiazepine receptors / 小脳顆粒細胞初代培養系 / ラット小脳 / 受容体結合実験 / [^3H]Ro15-4513 / ジアゼパム非感受性 / 抗けいれん作用 / フェノバルビタール / Ro19-4603 / ペンチレンテトラゾール / エタノール / イミダゾベンゾジアデピン / Ro15-4513 / ベンゾジアゼピン受容体 / prostaglandin E2 / Cu2+ / 酸化ストレス / 4-Hydroxynonenal / N-acetyl-L-cysteine / 筋萎縮性側索硬化症 … More Except Principal Investigator ^<36>Cl^- uptake / Phospholipase A_2 / GABA_A受容体 / dental anesthesiology / brain infarction / ethopharmacology / hypertension / aging / interaction of medicine / analgesic / sedative / 心拍 / 血圧 / 脳疾患 / 心柏 / 運動機能回復 / 歯科麻酔 / 脳梗塞 / 行動薬理学 / 高血圧 / 高齢 / 薬物相互作用 / 鎮痛剤 / 鎮静剤 / Up-regulation / Cerebellum / Bicuculline / Muscimol / GABA_A receptor / クラライドイオンチャネル / シナプトニューロソーム / [^<35>S]TBPS結合 / クロライドイオンチャネル / 亜急性投与 / アップレギュレーション / ^<36>Cl^-取込み / 小脳 / ビククリン / ムシモール / synaptoneurosome / Cultured cerebellar neuronal cells / ^<35>S-TBPS binding / SR 95531 / GABA antagonist / GABA_Areceptor / アンタゴニスト / アゴニスト / 培養神経細胞 / ^<36>Clイオンの取込み / 受容体結合実験 / アゴニスト作用 / IC_<50>値 / ビククリンメチオダイド / ピクロトキシン結合部位 / シナプトニュ-ロソ-ム / 小脳神経細胞初代培養系 / ^<35>SーTBPS結合 / ^<36>Cl^ーuptake / SR95531 / GABAアンタゴニスト / カルモデュリン / eNOS / ジストロフィン / 心肥大 / バナジウム有機錯体 / CaMKII / 神経再生 / 血管再生 / 神経変性疾患 / 神経血管ユニット / アミロイド前駆タンパク質 / アルツハイマー病治療薬 / T型カルシウムチャネル / ST101 / 薬物治療学 Less

Elucidation of the Intracellular PGE2 receptor Function with Appliance of Optical Functional NanoparticlePrincipal Investigator
- Principal Investigator
  
  ITO Yoshihisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Nihon University
Elucidation of mechanism underlying accelerated production of endogenous aldehyde in amyotrophic lateral sclerosis and development of new drug therapyPrincipal Investigator
- Principal Investigator
  
  ITO Yoshihisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nihon University
Drug development targeting for regeneration of neurovascular units in neurodegenerative disorders
- Principal Investigator
  
  FUKUNAGA Kohji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Suppression of function in automatic nerve and elder rat brain synaptoneurosomes for aged cerebral infarction rats with administration of sedatives and analgesics
- Principal Investigator
  
  KUDO Masaru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Studies on mechanism of neuronal death induced by an amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  ITO Yoshihisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Nihon University
Regulation of intracellar Ca^<2+> concentration and transcription factors in absence seizuresPrincipal Investigator
- Principal Investigator
  
  ITO Yoshihisa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nihon University
Studies on diazepam-insensitive benzodiazepine receptorsPrincipal Investigator
- Principal Investigator
  
  ITO Yoshihisa
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nihon University
Studies on binding sites of GABA_A receptor complexes in brain and cultured neuronal cells
- Principal Investigator
  
  FUKUDA Hideomi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nihon University
Studies on GABA_A receptor complexes in cultured cerebellar neuronal cells and synaptoneurosomes
- Principal Investigator
  
  FUKUDA Hideomi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nihon University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2007 2006 Other

All Journal Article Presentation Book Patent Other

[Book] わかりやすい薬理学－薬の効くプロセス－（第11版）2017
- Author(s)
  伊藤芳久、石毛久美子
- Total Pages
  487
- Publisher
  創風社
- ISBN
  9784883522385
- Data Source
  KAKENHI-PROJECT-15K14966
[Journal Article] Pathophysiological role of prostaglandin E2-induced up-regulation of the EP2 receptor in motor neuron-like NSC-34 cells and lumbar motor neurons in ALS model mice.2018
- Author(s)
  Kosuge Y, Miyagishi H, Yoneoka Y, Yoneda K, Nango H, Ishige K, Ito Y.
- Journal Title
  
  Neurochem Int.
  
  Volume: 印刷中 Pages: 132-139
- DOI
  10.1016/j.neuint.2017.06.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14966, KAKENHI-PROJECT-17K08965
[Journal Article] Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-342017
- Author(s)
  Nango, Hiroshi; Kosuge, Yasuhiro; Miyagishi, Hiroko; Sugawa, Kosuke; Ito, Yoshihisa; Ishige, Kumiko
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 135 Issue: 2 Pages: 64-71
- DOI
  10.1016/j.jphs.2017.09.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K04993, KAKENHI-PROJECT-17K08965, KAKENHI-PROJECT-15K14966
[Journal Article] Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis2015
- Author(s)
  Kosuge Y, Miyagishi H, Shinomiya T, Nishiyama K, Suzuki S, Osada N, Ishige K, Okubo M, Kawaguchi M, Ito Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 12 Pages: 1964-1968
- DOI
  10.1248/bpb.b15-00418
- NAID
  130005112645
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14966
[Journal Article] New insights into the mechanism of neurolathyrism : L-β-ODAP triggers [Ca^2+]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors2014
- Author(s)
  Kusama-Eguchi K, Miyano T, Yamamoto M, Suda A, Ito Y, Ishige K, Ishii M, Ogawa Y, Watanabe K, Ikegami F, Kusama T
- Journal Title
  
  Food Chem Toxicol
  
  Volume: 67 Pages: 113-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca(2+)]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors.2014
- Author(s)
  Kusama-Eguchi K, Miyano T, Yamamoto M, Suda A, Ito Y, Ishige K, Ishii M, Ogawa Y, Watanabe K, Ikegami F, Kusama T.
- Journal Title
  
  Food Chem Toxicol.
  
  Volume: 67 Pages: 113-122
- DOI
  10.1016/j.fct.2014.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Mithramycin, an Agent for Developing New Therapeutic Drugs for Neurodegenerative Diseases2013
- Author(s)
  Osada N, Kosuge Y, Ishige K, Ito Y
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 122 Pages: 251-256
- NAID
  10031196198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Prostaglandin E2-induced cell death is mediated by activation of EP2 receptors in motor neuron-like NSC-34 cells.2013
- Author(s)
  Miyagishi H, Kosuge Y, Yoneoka Y, Ozone M, Endo M, Osada N, Ishige K, Kusama-Eguchi K, Ito Y.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 121（4） Pages: 347-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Prostaglandin E2-induced cell death is mediated by activation of EP2 receptors in motor neuron-like NSC-34 cells2013
- Author(s)
  Miyagishi H, Kosuge Y, Yoneoka Y, Ozone M, Endo M, Osada N, Ishige K, Kusama-Eguchi K, Ito Y
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 121 Pages: 347-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Mithramycin, an agent for developing new therapeutic drugs for neurodegenerative diseases.2013
- Author(s)
  Osada N, Kosuge Y, Ishige K, Ito Y
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 122（4） Pages: 251-256
- NAID
  10031196198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis.2012
- Author(s)
  Miyagishi H, Kosuge Y, Ishige K, Ito Y.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 118 Pages: 225-236
- NAID
  10030454962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites.2012
- Author(s)
  Shinoda Y, Fujita K, Saito S, Matsui H, Kanto Y, Nagaura Y, Fukunaga K, Tamura S, Kobayashi T.
- Journal Title
  
  FEBS Lett.
  
  Volume: 586(19) Pages: 3024-3029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Expression of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis2012
- Author(s)
  Miyagishi H, Kosuge Y, Ishige K, Ito Y
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 225-236
- NAID
  10030454962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein phosphatase PPM1L to ER-Golgi membrane contact sites2012
- Author(s)
  Shinoda Y, Fujita K, Saito S, Matsui H, Kanto Y, Nagaura Y, Fukunaga K, Tamura S, Kobayashi T
- Journal Title
  
  FEBS Lett
  
  Volume: 586(19) Pages: 3024-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis2012
- Author(s)
  Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige and Yoshihisa Ito
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Issue: 2 Pages: 225-236
- DOI
  10.1254/jphs.11221FP
- NAID
  10030454962
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.2011
- Author(s)
  Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y, Maeda S.
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis2011
- Author(s)
  Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y, Maeda S
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590650
[Journal Article] Quantitative measurement of In Vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE2010
- Author(s)
  Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga SI
- Journal Title
  
  Mol. Cell Proteomics
  
  Volume: 9 Pages: 1133-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function2010
- Author(s)
  Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H
- Journal Title
  
  PLoS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKb eta in neurite spine formation, contributing to cognitive function.2010
- Author(s)
  Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H
- Journal Title
  
  PLoS One.
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Quantitative measurement of In Vivo phosphorylation states of CdkS activator p35 by Phos-tag SDS-PAGE.2010
- Author(s)
  Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga SI
- Journal Title
  
  Mol.Cell Proteomics.
  
  Volume: 9 Pages: 1133-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390109
[Journal Article] Study for Construction of BLS Training Course System in Dental Office2007
- Author(s)
  Osamu Nakanishi, Masato Sumitomo, Yasushi Sakuma, Kazu-ichi Yoshida, Masaru Kudo, Haruhisa Fukayama, Genji Someya, Yuzuru Kaneko
- Journal Title
  
  Journal of the Japanese Association for Dental Science 26
  
  Pages: 31-35
- NAID
  10018827074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17592101
[Journal Article] Natural drug extracts for a nutritive-tonic drink, promotes the induction of long-term potentiation in rat hippocampal dentate gyrus in vivo.2006
- Author(s)
  阪田泰子, 石毛久美子, 大財朋博, 伊藤芳久
- Journal Title
  
  Neurosci. Res. 55(3)
  
  Pages: 327-333
- NAID
  10020615482
- Data Source
  KAKENHI-PROJECT-17592101
[Journal Article] Natural drug extracts for a nutritive-tonic drink, promotes the induction of long-term potentiation in rat hippocampal dentate gyrus in vivo2006
- Author(s)
  Yasuko Sakata, Kumiko Ishige, Tomohiro Ohzai, Yoshihisa Ito
- Journal Title
  
  Neuroscience Research 25(3)
  
  Pages: 327-333
- NAID
  10020615482
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17592101
[Patent] 神経変性疾患治療薬2016
- Inventor(s)
  小菅康弘、石毛久美子、伊藤芳久
- Industrial Property Rights Holder
  小菅康弘、石毛久美子、伊藤芳久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-016245
- Filing Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 運動ニューロン様株化細胞NSC-34におけるPGE2前処置はEP2の発現増加を介してPGE2誘発細胞死を増強する2018
- Author(s)
  南郷拓嗣, 小菅康弘, 石毛久美子, 伊藤芳久
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 運動神経様株化細胞NSC-34におけるProstaglandin E2による神経突起伸長の促進2017
- Author(s)
  南郷拓嗣、小菅康弘、須川晃資、Seikwan Oh、伊藤芳久、石毛久美子
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎、長崎）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] NSC-34におけるPGE2による細胞分化に関する研究2017
- Author(s)
  南郷拓嗣、小菅康弘、伊藤芳久、石毛久美子
- Organizer
  第１回下総薬理学研究会 2017年6月24日
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] NSC-34におけるPGE2による突起伸長機構に関する研究2017
- Author(s)
  南郷拓嗣, 小菅康弘, 伊藤芳久, 石毛久美子
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] PEG修飾ナノグラフェンを基軸とするpH応答性ドラックデリバリーキャリアーの機能性解析2016
- Author(s)
  徳田亨, 須川晃資, 小菅康弘, 伊藤芳久, 大月穣
- Organizer
  第67回コロイドおよび界面化学討論会
- Place of Presentation
  北海道教育大学旭川校（北海道、旭川）
- Year and Date
  2016-09-22
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] ナノ酸化グラフェン修飾金ナノスターの作製と光学特性解析2016
- Author(s)
  徳田亨, 須川晃資, 小菅康弘, 伊藤芳久, 大月穣
- Organizer
  第6回CSJ化学フェスタ2016
- Place of Presentation
  タワーホール船堀（東京、江戸川）
- Year and Date
  2016-11-14
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 沖縄産植物由来エキスを用いた筋萎縮性側索硬化症（ALS）治療薬の開発2016
- Author(s)
  小菅康弘、石毛久美子、伊藤芳久
- Organizer
  第18回応用薬理シンポジウム
- Place of Presentation
  名古屋大学医学部（愛知、名古屋）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] Synthesis and Characterization of Nanographene Oxide-Modified Gold Nanostars2016
- Author(s)
  Kyo Tokuda, Kosuke Sugawa, Yasuhiro Kosuge, Yoshihisa Ito, Joe Otsuki
- Organizer
  KJF-ICOMEP2016
- Place of Presentation
  ACROS Fukuoka (FUKUOKA, FUKUOKA)
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 抗腫瘍性抗生物質Mithramycinの筋萎縮性側索硬化症治療薬としての可能性2016
- Author(s)
  兼古絵里菜、小菅康弘、鈴木里実、南郷拓嗣、石毛久美子、伊藤芳久
- Organizer
  第134回日本薬理学会関東部会
- Place of Presentation
  国際医療福祉大学薬学部（栃木、大田原）
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] Prostaglandin E2 promotes neurite outgrowth via EP2-cAMP signaling pathway in NSC-34 cells, a motor neuron-like cell line.2016
- Author(s)
  Hiroshi Nango, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito
- Organizer
  The Society for Neuroscience's 46th annual meeting, Neuroscience 2016
- Place of Presentation
  San Diego Convention Center, CA (USA)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] Functional evaluation of PEG-modified nanographene as a drug delivery career2016
- Author(s)
  TOKUDA, Kyo; SUGAWA, Kosuke; KOSUGE, Yasuhiro; OTSUKI, Joe; ITO, Yoshihisa
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学（京都・京田辺）
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] PGE2はPGE2-cAMPシグナル伝達系を介して運動ニューロン様株化細胞NSC-34の神経突起伸長を促進する2016
- Author(s)
  南郷拓嗣　小菅康弘　石毛久美子　伊藤芳久
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 低分子化合物を用いた新規筋萎縮性側索硬化症治療薬の開発2015
- Author(s)
  伊藤芳久, 小菅康弘, 石毛久美子
- Organizer
  第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
- Place of Presentation
  タワーホール船堀（東京・船堀）
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 筋萎縮性側索硬化症（ALS）モデルマウスにおけるprostaglandin E2代謝・輸送系の変動とその分布2015
- Author(s)
  高野あゆみ, 小菅康弘, 宮岸寛子, 遠藤愛美, 石毛久美子, 伊藤芳久
- Organizer
  第132回日本薬理学会関東部会
- Place of Presentation
  明海大学（千葉・浦安）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-15K14966
[Presentation] 運動ニューロン様株化細胞NSC-34におけるProstaglandin E2誘発細胞死にはEP2受容体の活性化が関与する2013
- Author(s)
  小菅康弘、宮岸寛子、長田暢宏石毛久美子、伊藤芳久
- Organizer
  第８６回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] PGE2受容体の発現上昇は筋萎縮性側索硬化症モデルマウスにおける運動ニューロン死に関与する2013
- Author(s)
  米田景子, 小菅康弘, 米岡祐貴, 宮岸寛子, 石毛久美子, 伊藤芳久
- Organizer
  第128回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2013-07-14
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 運動ニューロン様株化細胞NSC-34におけるProstaglandin E2誘発細胞死にはEP2受容体の活性化が関与する2013
- Author(s)
  小菅康弘, 宮岸寛子, 長田暢宏, 石毛久美子, 伊藤芳久
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症モデルマウス運動ニューロンにおけるPGE2受容体の発現変化2013
- Author(s)
  小菅康弘, 米岡祐貴, 米田景子, 西山賢太, 宮岸寛子, 石毛久美子, 伊藤芳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2013
- Place of Presentation
  熊本
- Year and Date
  2013-08-31
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] N-acetyl-L-cysteineを基点とした新規筋萎縮性側索硬化症(ALS)治療薬の開発2013
- Author(s)
  小菅康弘, 宮岸寛子, 齋藤弘明, 石毛久美子, 宮入伸一, 伊藤芳久
- Organizer
  第15回応用薬理シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-09-28
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 脳梗塞および筋萎縮性側索硬化症における小胞体ストレス誘導性転写因子CHOPを標的とした新規治療薬の可能性2012
- Author(s)
  伊藤芳久、小菅康弘、石毛久美子
- Organizer
  生体機能と創薬シンポジウム 2012
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症(ALS)モデルマウスにおけるprostaglandin E2増大機構2012
- Author(s)
  遠藤愛美, 宮岸寛子, 小菅康弘, 石毛久美子, 伊藤芳久
- Organizer
  第126回日本薬理学会関東部会
- Place of Presentation
  東京
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症モデルマウスにおけるmicrosomal prostaglandin E synthase-1の発現とその分布2012
- Author(s)
  宮岸寛子, 小菅康弘, 長田暢弘, 石毛久美子, 伊藤芳久
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 膜脂質由来毒性アルデヒド4-hydroxynonenalを標的としたALSの病態解明と新規治療薬探索2012
- Author(s)
  伊藤芳久, 小菅康弘, 宮岸寛子, 小野真一, 鈴木孝, 石毛久美子
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 運動ニューロン様株化細胞NSC-34におけるプロスタグランジンE2受容体の同定2012
- Author(s)
  小菅康弘, 宮岸寛子, 小曽根麻衣子, 米岡祐貴, 石毛久美子, 伊藤芳久
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 脳梗塞および筋萎縮性側索硬化症における小胞体ストレス誘導性転写因子CHOPを標的とした新規治療薬の可能性2012
- Author(s)
  伊藤芳久, 小菅康弘, 石毛久美子
- Organizer
  生体機能と創薬シンポジウム2012
- Place of Presentation
  神戸
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症（ALS）モデルマウスにおけるprostaglandin E2増大機構2012
- Author(s)
  遠藤愛美、宮岸寛子、小菅康弘、石毛久美子、伊藤芳久
- Organizer
  第126回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症モデルマウスにおけるPGE2受容体の発現変化2011
- Author(s)
  米岡祐貴, 宮岸寛子, 小菅康弘, 石毛久美子, 伊藤芳久
- Organizer
  第13回応用薬理シンポジウム
- Place of Presentation
  船橋
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症(ALS)モデルマウスの運動ニューロンにおけるPGE2受容体の発現解析2011
- Author(s)
  米岡祐貴, 宮岸寛子, 長田暢弘, 小菅康弘, 石毛久美子, 伊藤芳久
- Organizer
  第125回日本薬理学会関東部会
- Place of Presentation
  船橋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症（ALS）モデルマウスの運動ニューロンにおけるPGE2受容体の発現解析2011
- Author(s)
  米岡祐貴、宮岸寛子、長田暢弘、小菅康弘、石毛久美子、伊藤芳久
- Organizer
  第125回日本薬理学会関東部会
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 内因性アルデヒド4-hydroxynonenalを標的とした筋萎縮性側索硬化症(ALS)治療薬開発の可能性2011
- Author(s)
  宮岸寛子, 小菅康弘, 齋藤弘明, 石毛久美子, 宮入伸一, 伊藤芳久
- Organizer
  第125回日本薬理学会関東部会
- Place of Presentation
  船橋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 内因性アルデヒド4-hydroxynonenalを標的とした筋萎縮性側索硬化症（ALS）治療薬開発の可能性2011
- Author(s)
  宮岸寛子、小菅康弘、齋藤弘明、石毛久美子、宮入伸一、伊藤芳久
- Organizer
  第125回日本薬理学会関東部会
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] 筋萎縮性側索硬化症モデルマウス運動ニューロンにおけるPGE2受容体の発現変化
- Author(s)
  小菅康弘、米岡祐貴、米田景子、西山賢太、宮岸寛子、石毛久美子、伊藤芳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2013
- Place of Presentation
  熊本大学薬学部
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] PGE2受容体の発現上昇は筋萎縮性側索硬化症モデルマウスにおける運動ニューロン死に関与する
- Author(s)
  米田景子、小菅康弘、米岡祐貴、宮岸寛子、石毛久美子、伊藤芳久
- Organizer
  第128回日本薬理学会関東部会
- Place of Presentation
  早稲田大学国際会議場
- Data Source
  KAKENHI-PROJECT-23590650
[Presentation] N-acetyl-L-cysteineを基点とした新規筋萎縮性側索硬化症（ALS）
- Author(s)
  小菅康弘、宮岸寛子、齋藤弘明、石毛久美子、宮入伸一、伊藤芳久
- Organizer
  第15回応用薬理シンポジウム
- Place of Presentation
  コクヨホール
- Data Source
  KAKENHI-PROJECT-23590650
[]

1. FUKUDA Hideomi (50080172)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ISHIGE Kumiko (40212873)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. FUKUNAGA Kohji (90136721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. IWABUCHI Yoshiharu (20211766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MORIGUCHI Shigaki (70374949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. KUDO Masaru (90244863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 須川晃資 (40580204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 小菅康弘 (70383726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results

ITO Yoshihisa 伊藤 芳久

ITO Yosehisa 伊藤 芳久

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Elucidation of the Intracellular PGE2 receptor Function with Appliance of Optical Functional NanoparticlePrincipal Investigator

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Elucidation of mechanism underlying accelerated production of endogenous aldehyde in amyotrophic lateral sclerosis and development of new drug therapyPrincipal Investigator

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Drug development targeting for regeneration of neurovascular units in neurodegenerative disorders

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Suppression of function in automatic nerve and elder rat brain synaptoneurosomes for aged cerebral infarction rats with administration of sedatives and analgesics

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Studies on mechanism of neuronal death induced by an amyotrophic lateral sclerosisPrincipal Investigator

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Regulation of intracellar Ca^<2+> concentration and transcription factors in absence seizuresPrincipal Investigator

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Studies on diazepam-insensitive benzodiazepine receptorsPrincipal Investigator

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Studies on binding sites of GABA_A receptor complexes in brain and cultured neuronal cells

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Studies on GABA_A receptor complexes in cultured cerebellar neuronal cells and synaptoneurosomes

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[Book] わかりやすい薬理学－薬の効くプロセス－（第11版）2017

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[Journal Article] Pathophysiological role of prostaglandin E2-induced up-regulation of the EP2 receptor in motor neuron-like NSC-34 cells and lumbar motor neurons in ALS model mice.2018

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[Journal Article] Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-342017

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[Journal Article] Characterization of Motor Neuron Prostaglandin E2 EP3 Receptor Isoform in a Mouse Model of Amyotrophic Lateral Sclerosis2015

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NAID

ITO Yoshihisa 伊藤芳久

ITO Yosehisa 伊藤芳久