Haseba Takeshi 長谷場健

… Alternative Names

HASEBA Takeshi 長谷場健

長谷場健ハセバタケシ

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Researcher Number	50156329
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013 – 2015: 日本医科大学, 医学部, 准教授 2009 – 2010: Nippon Medical School, 医学部, 准教授 2008: Nippon Medical School, 医学部, 講師 1999 – 2001: 日本医科大学, 医学部, 講師 1992 – 1993: 日本医科大学, 医学部, 講師 1987: 日本医科大学, 医学部・法医学, 助手 1986: 日本医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Legal medicine / Legal medicine / 応用微生物学・発酵学 Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator アルコール代謝 / ノックアウトマウス / Class III ADH / Class I ADH / 活性調節 / マウス / アルコール脱水素酵素 / ADH1 / ADH3 / アルコール嗜好性 … More / CLASS I ALCOHOL DEHYDROGENASE / GENOMIC DNA ANALYSIS / ENZYME REGULATION / MICROSPECTROMETRY / TISSUE DAMAGES / ALCOHOL METABOLISM / KNOCKOUT MOUSE / CLASS III ALCOHOL DFHYDROGENASE / ADH大量発現系 / 肝ADH酵素量 / Class III ADH遺伝子クローニング / ADH強発現株細胞 / Class III ADH遺伝子 / 顕微分光酵素活性測定 / 活性・構造相関 / リコンビナントADH / 遺伝子解析 / 顕微分光計測 / 組織障害 / Intracellular hydrophobicity / Alcohol metabolism / Activity regulation / Solution hydrophobicity / Alcohol dehydrogenase / Mouse / マイクロダイアリシス法 / 疎水物質 / ClassIおよびIIIADH / 細胞内疎水性 / 溶液疎水性 / Class III / Class I / immuneenzyme assay / time Change / dose effect / acute alcohol administration / mouse liver / isozyme / LowKm / HighKm / ADH / 急性アルコール投与 / アルコール性脂肪肝 / アルコール代謝亢進 / アルコール医学 / 社会医学 / ピラゾール感受性 / アルコール依存症 / アルコール性肝障害 / 慢性アルコール摂取 / アルコール依存 / アルコール肝障害 / 用量効果 / アルコール感受性 / 血中アルコール動態 / グルタチオン依存性ホルムアルデヒド脱水素酵素 / 酵素量 / 臓器分布 / アセトアルデヒド / エタノール / 急性アルコール中毒 / 性差 / 組織酵素量 / ADH 3 / ADH 1 / アルコール代謝動態 … More Except Principal Investigator Liposome / Listeria / Legionella / Intracellular Multiplied / 治療 / 呼吸器感染粧 / リポソーム / Immunoenzyme assay / Acute ethanol administration / Chronic ethanol feeding / Mouse liner / Isozyme / Low Km / High Km / Alcohol dehydrogenase / 呼吸器感染症 / リステリア / レジオネラ / 細胞内増殖菌 / ターゲティング療法 Less

The roles of high Km ADH3 on alcohol metabolism and alcoholc disorders under chronic alcohol comsumpsionPrincipal Investigator
- Principal Investigator
  
  Haseba Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nippon Medical School
Roles of Class III ADH (ADH3), a new alcohol metabolizing enzyme, on biosensitivities for alcoholPrincipal Investigator
- Principal Investigator
  
  HASEBA Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Nippon Medical School
ROLE OF CLASS III ALCOHOL DEHYDROGENASE (ADH3), A HOUSEKEEPING ENZYME FOR CYTOTOXICITY, IN ALCOHOL METABOLISM -IN VIVO STUDY USING KNOCKOUT MICE AND INVITRO STUDY ON ENZYME REGULATION-Principal Investigator
- Principal Investigator
  
  HASEBA Takeshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  NIPPON MEDICAL SCHOOL
CONTRIBUTION OF ACIDIC ADH(CLASS III) TO ALCHOL METABOLISMPrincipal Investigator
- Principal Investigator
  
  HASEBA Takeshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  NIPPON MEDICAL SCHOOL
Study on Development of New Methods in the Treatment of Infection Caused by Intracellular Multiplied Bacteria
- Principal Investigator
  
  SAITO Atsushi, 黒須三恵
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Ryukyu University
  Nippon Medical School
  Nagasaki University
各種アルコール投与条件下におけるアルコール代謝速度へのADHの寄与についてPrincipal Investigator
- Principal Investigator
  
  黒須三恵, 長谷場健
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Nippon Medical School

All 2016 2015 2014 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] 生活指導事典-生活指導・対人援助に関わる人のために6-10.アルコール依存者とその家族への支援「アルコール感受性と依存」2010
- Author(s)
  日本生活指導学会(著), 竹内常一(編集), 長谷場健(分担)
- Total Pages
  319
- Publisher
  エイデル研究所
- Data Source
  KAKENHI-PROJECT-20590689
[Book] 生活指導辞典(日本生活指導学会編)(第6章児童福祉・家族福祉と生活指導・対人援助・6-10アルコール依存症者とその家族への支援「アルコール感受性と依存」総頁数329)2010
- Author(s)
  長谷場健
- Total Pages
  240
- Publisher
  エイデル研究所出版
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] ALDH2遺伝子多型は飲酒後の脱水傾向に影響するー飲酒後のヘマトクリット値の変動よりー2016
- Author(s)
  大島俊二、椎谷幸恵、神田智正、長谷場健、大野曜吉
- Journal Title
  
  アルコールと医学生物学
  
  Volume: 34
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] Effects of ALDH2 genetic polymorphism on the adaptive change in alcohol metabolism due to continuous moderate alcohol consumption in humans2015
- Author(s)
  Ohshima S., Haseba T., Nemoto A., Siiya S., Kanda T., Ohno Y.
- Journal Title
  
  Food & Nutri. Sci.
  
  Volume: 6 Pages: 195-204
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] Alcohol dehydrogenase 3 ccontributes to the protection of liver from nonalcoholic steatohepatitis2015
- Author(s)
  Goto M., Kitamura H., Alam M-M., Ota N., Haseba T., Akimoto T., Shimizu A., T-Yamamoto T., Yamamoto M., Motohashi H.
- Journal Title
  
  Genes to Cells
  
  Volume: 20
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] アルコール代謝におけるNon-ADH pathwayの正体とClass III alcohol dehydrogenase (ADH3)2014
- Author(s)
  長谷場　健
- Journal Title
  
  日本アルコール・薬物医学雑誌
  
  Volume: 49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] 飲酒後のアルコール代謝動態と生理的変動に関するデータベース（第2報）－ALDH2*1/*1型の男性がビールあるいは焼酎を食事の有無で適量飲酒した場合ー2014
- Author(s)
  大島俊二、福田和郎、阿部裕子、長谷場　健、大野曜吉
- Journal Title
  
  アルコールと医学生物学
  
  Volume: ３３ Pages: 1-11
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice2014
- Author(s)
  Yi H-S., Lee Y-S., Byun J-S., Seo W., Jeong J-M., Park O., Duester G., Haseba T., Kin S.C., Park K-G., Gao B., Jeong W-I.
- Journal Title
  
  Hepatology
  
  Volume: 60 Issue: 3 Pages: 1044-1053
- DOI
  10.1002/hep.27137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460879
[Journal Article] Dose-dependent change in elimination kinetics of ethanol due to shift of dominant metabolizing enzyme from ADH 1 (Class I) to ADH 3 (Class III) in mouse.2011
- Author(s)
  Haseba T., Kameyama K., Mashimo K., Ohno Y.
- Journal Title
  
  Int.J.Hepatology(特集"Advances in alcoholic liver disease") (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] A new view of alcohol metabohsm and alcohohsm-Role of the high-Kmclass III alcohol dehydrogenase (ADH3)2010
- Author(s)
  Haseba T., Ohno Y.
- Journal Title
  
  Int.J.Environ.Res.Public Health
  
  Volume: 7 Pages: 1076-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] A new view of alcohol metabolism and alcoholism-role of the high-Km Class III alcohol dehydrogenase (ADH 3)-.2010
- Author(s)
  Haseba T., Ohno Y.
- Journal Title
  
  Int.J.Environ.Res.Public Health
  
  Pages: 1076-1092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] 飲酒条件が細胞内酸化還元度およびアルコール代謝速度に及ぼす影響2010
- Author(s)
  阿部裕子、大島俊二、神田智正、長谷場健、大野曜吉
- Journal Title
  
  アルコールと医学生物学
  
  Volume: 29 Pages: 1-5
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] アルコール代謝の新しい視点-High Km ADH 3(CLass III)のアルコール代謝およびその生体作用における意義-」2009
- Author(s)
  長谷場健
- Journal Title
  
  日本アルコール・薬物医学会雑誌 44(2)
  
  Pages: 78-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] アルコール代謝の新しい視点-High Km ADH3 (Class III)のアルコール代謝およびその生体作用における意義-2009
- Author(s)
  長谷場建
- Journal Title
  
  日本アルコール・薬物医学会誌 44
  
  Pages: 78-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Journal Article] Ph ytophenols in whisky lower blood acetaldehyde levelsby depressing alcohol metabolism through inhibition of alcohol dehydrogenase ADH1 (Class I)in mice.2008
- Author(s)
  Haseba T., Sugimoto J., Sato S., Ohno Y.
- Journal Title
  
  Metabolism 57
  
  Pages: 1753-1759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] 慢性アルコール摂取によるアルコール代謝亢進に寄与するNon-ADH1 pathwayの正体2016
- Author(s)
  長谷場健、丸山基世、秋元敏夫
- Organizer
  35回アルコール医学生物学研究会学術集会（JASBRA)
- Place of Presentation
  東京
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] Class I alcohol dehydrogenase (ADH 1) is indispensable for continuos alcohol drinking (CAD) to develop alcoholism2015
- Author(s)
  Haseba T. Maruyama M. Akimoto T. Ohno Y.
- Organizer
  15th ESBRA (European Society for Biomedical Research on Alcoholism)
- Place of Presentation
  Valencia, Spain
- Year and Date
  2015-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] 急性アルコール中毒下での臓器障害とアルコール脱水素酵素の役割2014
- Author(s)
  佐久間隆弘、長谷場　健、丸山基世、秋元敏雄、大野曜吉
- Organizer
  日本法医学会学術関東地方集会
- Place of Presentation
  東京
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] アルコール代謝におけるNon-ADH pathwayの正体とClass III alcohol dehydrogenase (ADH3)2014
- Author(s)
  長谷場　健
- Organizer
  アルコール・薬物依存関連学会合同学術総会
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-25460879
[Presentation] Roles of ADH3 in ethanol metabolism in major organs and in ethanol body distribution-A comparison with ADH1.2010
- Author(s)
  Haseba T., 他7名
- Organizer
  ISBRA World Congress(国際アルコール生物医学会)
- Place of Presentation
  パリ
- Year and Date
  2010-09-15
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] Roles of ADH 3 in ethanol metabolism in major organs and in ethanol distribution-A comparison with ADH 1.2010
- Author(s)
  Haseba T., Ohkusa M., Tanabe T., Yagi Y., Nakao S., Ye Y., Dyester G., Ohno Y.
- Organizer
  2010 ISBRA World Congress
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] Alcohol dehydrogenases -their biological and medical roles-.2009
- Author(s)
  Haseba T.
- Organizer
  In Vietnam Academy Science and Technology, Institute of Tropical Biology
- Place of Presentation
  Ho Chi Minh City, Vietnam(Invited lecture)
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] Alcohol dehydrogenases-their biological and medical roles-.2009
- Author(s)
  Haseba T.
- Organizer
  Vietnam Academy Science and Technology
- Place of Presentation
  Ho Chi Minh City, Vietnum
- Year and Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] Roles of two major alcohol dehydrogenase isozymes, ADH1(Class I)and ADH3 (Class III), in pharmacokinetics of blood ethanol.2008
- Author(s)
  Haseba T., Duester G., Ohno Y.
- Organizer
  The 2^<nd>United States-Japan Joint Workshop on Alcohol-Related Problems.
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-20590689
[Presentation] Roles two major alcohol dehydrogenase isozymes, ADH 1 and ADH 3, in pharmacokinetics of blood ethanol.2008
- Author(s)
  Haseba T., Duester G., Ohno Y
- Organizer
  The 2nd USA-Japan Joint Workshop on Alcohol-related Problems
- Place of Presentation
  Yokohama, JPN(Workshop)
- Data Source
  KAKENHI-PROJECT-20590689

1. KUROSU Mitsuyasu (70103984)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 富田ゆかり (20159049)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. AKIMOTO Toshio (30184112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. MARUYAMA Motoyo (60709757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HIRAI Yukihiko (10089617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMAMOTO Isao (30277917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAMEYAMA Kouji (60150736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASHIMO Keiko (90113000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUROSAWA Norio (30234602)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMIZU Akio (20235641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAITO Atsushi (90039842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIGENO Yoshiteru (50162590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山口恵三 (30136676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 河野茂 (80136647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMAGUCHI Keiso

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Haseba Takeshi 長谷場 健

HASEBA Takeshi 長谷場 健

長谷場 健 ハセバ タケシ

Research Projects

Research Products

Co-Researchers

The roles of high Km ADH3 on alcohol metabolism and alcoholc disorders under chronic alcohol comsumpsionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Class III ADH (ADH3), a new alcohol metabolizing enzyme, on biosensitivities for alcoholPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ROLE OF CLASS III ALCOHOL DEHYDROGENASE (ADH3), A HOUSEKEEPING ENZYME FOR CYTOTOXICITY, IN ALCOHOL METABOLISM -IN VIVO STUDY USING KNOCKOUT MICE AND INVITRO STUDY ON ENZYME REGULATION-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CONTRIBUTION OF ACIDIC ADH(CLASS III) TO ALCHOL METABOLISMPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Development of New Methods in the Treatment of Infection Caused by Intracellular Multiplied Bacteria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

各種アルコール投与条件下におけるアルコール代謝速度へのADHの寄与についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生活指導事典-生活指導・対人援助に関わる人のために6-10.アルコール依存者とその家族への支援「アルコール感受性と依存」2010

Author(s)

Total Pages

Publisher

Data Source

[Book] 生活指導辞典(日本生活指導学会編)(第6章児童福祉・家族福祉と生活指導・対人援助・6-10アルコール依存症者とその家族への支援「アルコール感受性と依存」 総頁数329)2010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] ALDH2遺伝子多型は飲酒後の脱水傾向に影響するー飲酒後のヘマトクリット値の変動よりー2016

Author(s)

Journal Title

Data Source

[Journal Article] Effects of ALDH2 genetic polymorphism on the adaptive change in alcohol metabolism due to continuous moderate alcohol consumption in humans2015

Author(s)

Journal Title

Data Source

[Journal Article] Alcohol dehydrogenase 3 ccontributes to the protection of liver from nonalcoholic steatohepatitis2015

Author(s)

Journal Title

Data Source

[Journal Article] アルコール代謝におけるNon-ADH pathwayの正体とClass III alcohol dehydrogenase (ADH3)2014

Author(s)

Journal Title

Data Source

[Journal Article] 飲酒後のアルコール代謝動態と生理的変動に関するデータベース（第2報）－ALDH2*1/*1型の男性がビールあるいは焼酎を食事の有無で適量飲酒した場合ー2014

Author(s)

Journal Title

Data Source

[Journal Article] Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dose-dependent change in elimination kinetics of ethanol due to shift of dominant metabolizing enzyme from ADH 1 (Class I) to ADH 3 (Class III) in mouse.2011

Author(s)

Journal Title

Haseba Takeshi 長谷場健

HASEBA Takeshi 長谷場健

長谷場健ハセバタケシ

[Book] 生活指導辞典(日本生活指導学会編)(第6章児童福祉・家族福祉と生活指導・対人援助・6-10アルコール依存症者とその家族への支援「アルコール感受性と依存」総頁数329)2010

[Journal Article] 飲酒後のアルコール代謝動態と生理的変動に関するデータベース（第2報）－ALDH21/1型の男性がビールあるいは焼酎を食事の有無で適量飲酒した場合ー2014