YAMATO Kenji 大和建嗣

… Alternative Names

大和健嗣ヤマトケンジ

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Researcher Number	50174751
External Links
Affiliation (based on the past Project Information) *help	2015 – 2016: 筑波大学, 医学医療系, 研究員 2012: 筑波大学, 医学医療系, 研究員 2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 講師 2008: Tokyo Medical and Dental University, 大学院医歯学総合研究科, 講師 … More 2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究料, 講師 2004 – 2005: 東京医科歯科大学, 歯学部, 講師 2000 – 2004: Tokyo Medical and Dental University, Graduate School, Division of Oral Health Science Lecturer, 大学院・医歯学総合研究科, 講師 1996 – 1999: 東京医科歯科大学, 歯学部, 講師 1995: 東京医科歯科大学, 医学部, 講師 1992 – 1993: Tokyo Med. & Dent. Univ., Fac. Dent. Lecturer, 歯学部, 講師 Less
Review Section/Research Field	Principal Investigator Morphological basic dentistry / 病態科学系歯学(含放射線系歯学) / Pathobiological dentistry/Dental radiology Except Principal Investigator Morphological basic dentistry / Applied pharmacology / Periodontal dentistry
Keywords	Principal Investigator siRNA / G1 arrest / p21 / E6 / BMP-2 / apoptosis / HPV / Rb / アポトーシス / アクチビン … More / p53 / TGF-β / BMP / WAF1> / activin / RNAi / G1期停止 / growth / Cdt / p21^<CIP1 / IL-1 / TGFβ / ODF / Smad / ルシフェラーゼ / RNA干渉 / WAF1 / CIP1 / 骨髄腫 / in vivo / siRN / HPV18 / HPV16 / P / BPV / E7 / myeloma / アポプトーシス / Bb / cell cycle / TAK1 / vitamin D3 / osteoclast / プロスタグランジンE2 / IL-1α / 骨吸収 / 骨芽細胞 / ビタミンD3 / 破骨細胞 / Smad 7 / Smad 2 / p21^<CID1 / MAPキナーゼ / 細胞周期停止 / Smad2 / GT arrest / Smad7 / Smad6 / Samd2 / 皮膚 / GFP / 子宮頸癌 / ラフトカルチャー / 実験腫瘍学 / CDK4 / サイクリンD / アポートシス / 細胞周期 / サイクリン / Tax / HTLV-I … More Except Principal Investigator CDT / SSCP / PCR / 癌抑制遺伝子 / p53 / MDM2 / TP53変異細胞 / iASPP / ΔNp73 / p73活性化 / がん / p73 / caspase / glycosphingolipids / apoptosis / monocyte-macrophage / exotoxin / A. ACTINOMYCETEMCOMITANS / periodontopathic bacteria / 単球・リンパ系細胞 / カスペース / 糖脂質 / アポトーシス / 単級・リンパ球 / 外毒素 / A.actinomycetemcomitans / 歯周病細菌 / Oral cancer / Squamous cell carcinoma / Tumor suppressor gene / P53 / Immunohistochemistry / 抗p53抗体 / 口腔癌 / 扁平上皮癌 / 免疫組織化学 / トランスホーメーション / トランスアクチベーション / 変異 / 口腔扁平上皮癌 Less

A basic research of p73 activation as a novel treatment for p53-mutant type cancer
- Principal Investigator
  
  HYODO Ichinosuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Tsukuba
Organotypic epithelial raft cultures as HPV-related cancer models for evaluating siRNA and its delivery systemPrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  University of Tsukuba
  Tokyo Medical and Dental University
siRNA-mediated highly potent and specific RNAi in human culturedcells and its signalsPrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Molecular biological analysis of the exotoxin derived from periodontopathic bacteria on peridontal medicine
- Principal Investigator
  
  NISHIHARA Tatsuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Kyushu Dental College
In vitro and in vivo growth suppression of HPV-related cancer cells by siRNA targeting E6 oncogenePrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Inductioin and activation of p53 tumor suppressor protein by Cdt in HPV-related cancer cellsPrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University
Anti-myeloma activity of members of the TGF-β family with induction of growth arrest and apoptosis^*Principal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University
Role of Smads and TAK1 in BMP-induced growth arrest and apoptosisPrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
The effect of activin A, an antagonist of IL-1 and IL-6, on osteoclast formation.Principal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Tokyo Medical and Dental University
Intracellular signals of activin-A mediating growtharrest and apoptosisPrincipal Investigator
- Principal Investigator
  
  YAMATO Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
アクチビンAによる骨髄腫細胞アポートシス機構の解析治療応用への可能性の検討Principal Investigator
- Principal Investigator
  
  大和建嗣
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
アクチビンによるB細胞アポトーシスの発現機序の解明Principal Investigator
- Principal Investigator
  
  大和建嗣
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
「口腔扁平上皮癌で見いだされた変異型p53癌抑制遺伝子の細胞癌化における役割」
- Principal Investigator
  
  TSUCHIDA Nobuo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
ヒトT細胞白血病ウイルスによる癌化機構の分子生物学的解析Principal Investigator
- Principal Investigator
  
  大和建嗣
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Molecular diagnosis of oral cancer based on aberrant expression and structural alterations of the p53 tumor suppressor gene
- Principal Investigator
  
  TSUCHIDA Nobuo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University

All 2012 2011 2010 2009 2008 2007 2006 2004 2003

All Journal Article Presentation Patent

[Journal Article] The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome2012
- Author(s)
  Egawa, N., et al
- Journal Title
  
  J.Virol.
  
  Volume: 86 Issue: 6 Pages: 3276-3281
- DOI
  10.1128/jvi.06450-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21370084, KAKENHI-PROJECT-22592084, KAKENHI-PUBLICLY-23114510, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23590375, KAKENHI-PROJECT-23790517, KAKENHI-PROJECT-23791303, KAKENHI-PROJECT-24650622
[Journal Article] Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification.2011
- Author(s)
  Yamato K. et al.
- Journal Title
  
  Cancer Gene Ther.
  
  Volume: 18 Issue: 8 Pages: 587-597
- DOI
  10.1038/cgt.2011.28
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115004, KAKENHI-PROJECT-21310123, KAKENHI-PROJECT-22592084, KAKENHI-PUBLICLY-23114510, KAKENHI-PROJECT-23651200, KAKENHI-PROJECT-23791303
[Journal Article] Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells2011
- Author(s)
  Endo, S., Yamato, K., Hirai, S., Moriwaki, M., Fukuda, K., Suzuki, H., Abei, M., Nakagawa, I. and Hyodo, I
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 605-613
- NAID
  10029291334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592084
[Journal Article] Functional dissection of siRNA sequence by systematic DNA substitution : short interfering DNA-RNA chimera with a DNA seed arm is a powerful tool for mammalian gene silencing with virtually no off-target effect.2009
- Author(s)
  Ui-Tei, K., Naito, Y., Zenno, S., Nishi, K., Yamato. K., Takahashi, F., Juni, A., Saigo, K.
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 2152-2162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592169
[Journal Article] New highly potent and specific E6 and E7 siRNAs for treatment of HPV16-positive cervical cancer2008
- Author(s)
  Yamato, K., Yamada, T., Kizaki, M., Ui-Tei, K., Natori, Y., Fujino, M., Nishihara, T., Ikeda, Y., Nasu, Y., Saigo, K., Yoshinouchi, M
- Journal Title
  
  Cancer Gene Ther 15
  
  Pages: 140-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592169
[Journal Article] Functional dissection of siRNA sequence by systematic DNA substitution : short interfering DNA-RNA chimera with a DNA seed arm is a powerful tool for mammalian gene silencing with virtually no off-target effect.2008
- Author(s)
  Ui-Tei, K., Naito, Y., Zenno, S., Nishi, K., Yamato, K., Takahashi, F., Juni, A., Saigo, K
- Journal Title
  
  Nucleic Acids Res. 36
  
  Pages: 2152-2162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592169
[Journal Article] New highly potent and specific E6 and E7 siRNAs for treatment of HPV16-positive cervical cancer.2008
- Author(s)
  Yamato, K., et. al.
- Journal Title
  
  Cancer Gene Ther. 15
  
  Pages: 140-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592169
[Journal Article] Myeloperoxidase (MPO) is a key regulator of oxidative stress-mediated apoptosis in myeloid leukemic cells2007
- Author(s)
  Nakazato, T., Sagawa, M., Yamato, K., Xian, M., Yamamoto, T., Suematsu, M, Ikeda, Y., Kizaki, M.
- Journal Title
  
  Clin.Cancer Res 13
  
  Pages: 5436-5445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592169
[Journal Article] Induction of cell death in human papillomavirus 18-positive cervical cancer cells by E6 siRNA.2006
- Author(s)
  Yamato, K. et al.
- Journal Title
  
  Cancer Gene Therapy 13
  
  Pages: 234-241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390615
[Journal Article] Eradication of HPV post-surgical treatments, its correlation with specific types, types of surgery and the physical status.2004
- Author(s)
  Fen, J., Yoshinouchi, M., Nakamura.K., Kodama, J., Nasu, Y., Yamato, K., Hiramatsu, Y.
- Journal Title
  
  Oncol.Rep. 12
  
  Pages: 375-379
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591991
[Journal Article] Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress : implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species.2004
- Author(s)
  Ito, K., Nakazato, T., Yamato, K., Miyakawa, Y., Yamada, T.,, Hozumi, N., Segawa, K., Ikeda, Y., Kizaki, M.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 1071-1078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591991
[Journal Article] Induction of apoptosis in human myeloid leukemia cells by 1'-acetoxychavicol acetate (ACA) through a mitochondrial-and Fas-mediated dual mechanism.2004
- Author(s)
  Ito, K., Nakazawa, T., Murakami, A., Yamato, K., Miyakawa, Y., Yamada, T., Hozumi, N., Ohigashi, H., Ikeda, Y., Kizaki, M.
- Journal Title
  
  Clinical Cancer Res. 10
  
  Pages: 2120-2130
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591991
[Journal Article] Caffeine induces G2/M arrest and apoptosis via novel p53-dependent pathway in NB4 promonocytic leukemia cells.2003
- Author(s)
  Ito, K., Nakazoto, T., Miyakawa, Y., Yamato, K., Ikeda, Y., Kizaki, M.
- Journal Title
  
  J.cell.Physiol. 196
  
  Pages: 276-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591991
[Journal Article] In vitro and in vivo growth suppression of human papillomavirus (HPV)16-positive cervical cancer cells by E6 siRNA.2003
- Author(s)
  Yoshinouchi, M., Yamada, T., Kizaki, M., Fen, J., Koseki, T., Ikeda, Y., Nishihara, T., Yamato, K.
- Journal Title
  
  Mol.Ther. 8
  
  Pages: 762-768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591991
[Patent] ヒトパピローマ16型遺伝子を標的とする二本鎖核酸分子およびそれを含む医薬2008
- Inventor(s)
  大和建嗣, 名取幸和, 山田健人, 吉野内光夫
- Industrial Property Rights Holder
  大和建嗣, 名取幸和, 山田健人, 吉野内光夫
- Filing Date
  2008-04-30
- Overseas
- Data Source
  KAKENHI-PROJECT-19592169
[Patent] ヒトパピローマ1 6型遺伝子を標的とする二本鎖核酸分子およびそれを含む医薬2008
- Inventor(s)
  大和建嗣, 名取幸和, 山田健人, 吉野内光夫
- Industrial Property Rights Holder
  東京医科左同
- Filing Date
  2008-04-30
- Overseas
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] ヒト胃癌細胞に対するclassIII HDAC阻害剤 tenovin-6の抗腫瘍効果に関する検討2012
- Author(s)
  廣瀬充明（代表）、遠藤慎治、齋藤梨絵、上野　卓教、鈴木英雄、大和　建嗣、兵頭一之介
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  ロイトイン札幌（札幌）
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] Identification of a short RNA segment in the siRNA seed region required for efficient RNAi2012
- Author(s)
  大和建嗣（代表）、遠藤慎治
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡市）
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] Identification of a short RNA segment in the siRNA seed region required for efficient RNAi2012
- Author(s)
  大和建嗣
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡 (福岡市)
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification2011
- Author(s)
  Yamato, K
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] AGO2-association, microRNA suppression and cytotoxicity ofRNA-DNA chimera modified siRNA2011
- Author(s)
  大和建嗣
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification.2010
- Author(s)
  Yamato, K.
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22592084
[Presentation] 部分的DNA置換によるsiRNA配列の機能解析 : シード領域をDNAに置換したsiRNAはoff-target効果がない2008
- Author(s)
  程久美子, 内藤雄樹, 善野修平, 西賢二, 大和建嗣, 従二綾, 田中愛, 西郷薫
- Organizer
  第3 1回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] 2本鎖RNA-DNAキメラによるHPV16 E6E7特異的RNAiの誘導Induction of HPV16 E6E7-specific RNAi in cervical cancer cells by double strand RNA-DNA chimeras2008
- Author(s)
  大和建嗣, 吉野内光夫, 山田健人
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] 2本鎖RNA-DNAキメラによるHPV16 E6E7特異的RNAiの誘導2008
- Author(s)
  大和建嗣, 吉野内光夫, 山田健人
- Organizer
  第6 7回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] 部分的DNA置換によるsiRNA配列の機能解析 : シード領域をDNA に置換したsiRNAはoff-target効果がないDNA-modified siRNA is responsible for significantly reduced off-target effet2008
- Author(s)
  程久美子, 内藤雄樹, 善野修平, 西賢二, 大和建嗣, 従二綾, 田中愛, 西郷薫
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] Potent and specific E6 and E7 siRNAs for treatment of HPV16-positive cervical cancer2007
- Author(s)
  大和建嗣, 吉野内光夫, 山田健人
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19592169
[Presentation] Potent and Specific E6 and E7 siRNAs for treatment of HPV16-positive cervical cancer2007
- Author(s)
  Yamato, K., et. al.
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19592169

1. NISHIHARA Tatsuji (80192251)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
2. TSUCHIDA Nobuo (60089951)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. ENOMOTO Shoji (40013940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KIZAKI Masahiro (20161432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 石井裕子 (00251546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ETO Yuzuru

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 西原達治

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TADOKORO Keiko (00236564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEDA Masaaki (20193211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAMOTO Hajime (60005014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMADA Taketo (60230463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. AKIFUSA Sumio (40295861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUJISAWA Toshiyuki (60265006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HYODO Ichinosuke (60416469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高橋信義 (90014258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 遠藤慎治 (40625919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本祥之 (00649288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMATO Kenji 大和 建嗣

大和 健嗣 ヤマト ケンジ

Research Projects

Research Products

Co-Researchers

A basic research of p73 activation as a novel treatment for p53-mutant type cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Organotypic epithelial raft cultures as HPV-related cancer models for evaluating siRNA and its delivery systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

siRNA-mediated highly potent and specific RNAi in human culturedcells and its signalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological analysis of the exotoxin derived from periodontopathic bacteria on peridontal medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vitro and in vivo growth suppression of HPV-related cancer cells by siRNA targeting E6 oncogenePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inductioin and activation of p53 tumor suppressor protein by Cdt in HPV-related cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-myeloma activity of members of the TGF-β family with induction of growth arrest and apoptosis^*Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Smads and TAK1 in BMP-induced growth arrest and apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of activin A, an antagonist of IL-1 and IL-6, on osteoclast formation.Principal Investigator

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Intracellular signals of activin-A mediating growtharrest and apoptosisPrincipal Investigator

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アクチビンAによる骨髄腫細胞アポートシス機構の解析治療応用への可能性の検討Principal Investigator

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アクチビンによるB細胞アポトーシスの発現機序の解明Principal Investigator

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「口腔扁平上皮癌で見いだされた変異型p53癌抑制遺伝子の細胞癌化における役割」

Principal Investigator

Project Period (FY)

YAMATO Kenji 大和建嗣

大和健嗣ヤマトケンジ