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NAKAKIMURA Kazuhiko
中木村 和彦
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Researcher Number
50180261
External Links
Affiliation (based on the past Project Information)
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2003: 山口大, 医学部, 助教授
1996 – 2002: Yamaguchi Univ.Sch.of Med., Associate Professor, 医学部, 助教授
1994 – 1995: Yamaguchi University, Hospital Assistant Professor, 医学部・附属病院, 講師
1994 – 1995: 山口大学, 医学部附属病院, 講師
1990 – 1993: 山口大学, 医学部, 助手
1986 – 1988: Yamaguchi University Hospital・ Assistant, 医学部附属病院, 助手
1987: 山口大学, 医学部付属病院, 助手
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies
Except Principal Investigator
麻酔学
/
Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
ラット / 脳虚血耐性 / 局所脳虚血 / アデノシン / 脳梗塞 / 中大脳動脈閉塞 / アデノシンA_1受容体 / DPCPX / 急性硬膜下血腫 / NMDA受容体拮抗薬
…
More
/ 脳障害 / 硬膜下血腫 / 頭蓋内圧 / 脳代謝 / 脳循環 / 脳浮腫 / 血液脳関門 / acute subdural hematoma / NMDA antagonist / brain injuries / rat / イソフルラン / モルヒネ / 中枢神経 / 脊髄 / ミダゾラム / 電気刺激 / 鎮通 / 局所脳脊髄代謝 / 鎮痛 / 吸入麻酔薬 / 静脈麻酔薬 / 麻酔作用機序 / Isoflurane / Morphine / central nervous system / spinal cord / midazolam / electric stimulation / analgesia / local cerebral and spinal metabolic rate
…
More
Except Principal Investigator
Spinal glutamate / Analgesia / 脳虚血 / hypothermia / GFAP / 局所脳代謝 / 体外循環 / 細胞内情報伝達系 / 記憶障害 / Tolerance / Spinal cord / G Protein / Adenylate cyclase / Protein kinase C / Ca channel / Nitric oxide / NMDA antagonist / spinal cord ischemia / Pain / Spinal sensitization / PKC / NGF / 細胞骨格蛋白 / calpain / calpastatin / fodrin / calpain inhibitor-1 / アポトーシス / Apoptosis / MAP2 / Local Cerebral Glucose Utilization / 受容体結合 / 心停止後脳障害 / 脳蘇生 / 心肺蘇生 / 心室細動 / 高カリウム血症 / ニコチン性 アセチルコリン受容体 / ベクロニウム / mRNA / 卵母細胞 / 膜電位固定法 / アセチルコリン / Nitrous oxide / Acute tolerance / Substance P-receptor / Monoamine / 低酸素性脳症 / 代謝性脳症 / 遅発性神経細胞壊死 / 興奮性神経伝達物質 / マイクロダイアリス / 薬物療法 / 海馬CA_1 / 神経伝達物質 / セカンドメッセンジャ- / brain ischemia / delayed neuronal death / neurotransmitter derangements / intracellular signal transduction / microdialysis / neurobehavioral disturbance / drug theraphy / N-type Ca channel / α2-receptor / Intracellular spinal transduction / 鎮痛 / 耐性発現 / オピオイド / モノアミン / α_2受容体 / 情報伝達系 / G蛋白質 / アデニル酸シクラーゼ / 一過性脊髄虚血 / 脊髄血流量 / 対麻痺 / 一酸化窒素 / 興奮性アミノ酸 / 低体温 / spinal cord blood flow / paraplegia / nitric oxide / excitatory amino acid / Ilyperalgesia / 疼痛 / 脊髄過敏 / 痛覚過敏 / 触覚過敏 / 脊髄マイクロダイアリス / グルタメート放出 / プロテインキナーゼC / 神経成長因子 / Cキナーゼ / 神経栄養因子 / シナプス可塑性 / 脱抑制機構 / Hyperalgesia / 虚血性神経細胞死 / 細胞骨格タンパク質 / 脳低温 / 細胞内情報伝達 / カルパイン / カルパスタチン / フォドリン / cerebral ischemia / ischemic neuronal death / cytoskeleton / 神経因性疼痛, / 神経可塑性, / 脊髄グルタメート, / c-fos表現, / アポトーシス, / 介在ニューロン死, / 栄養因子治療 / 神経因性疼痛 / 神経可塑性 / 脊髄グルタメート / c-fos発現 / 介在ニューロン死 / Neuropathic pain / Central sensitization / Neurotrophic factor / Cytokines / Neuropathic Pain / Neuronal Prasticity / C-fos Expression / Necrosis of Interneurons / Treatment of Nerve Growth Factor / 脊髄虚血 / 家兎 / ネクローシス / マイクログリア / アストロサイト / マイクロファージ / グリア細胞TUNEL染色 / アガロース電気泳動法 / Nauta染色 / RAM-11 / ストレス蛋白 / rabbit / necrosis / apoptosis / microglia / astrocyte / macrophage / 心臓大血管手術 / 脳障害 / 血液脳関門 / S100b蛋白 / NSE / Neuron specific enolase / 脳浮腫 / 血液脳関門破綻 / 開胸返血 / エバンスブルー / cardiovascular surgery / neurological complication / blood-brain barrier / S1OOb protein / 中枢神経 / 虚血耐性 / 高気圧酸素 / 耐性関連遺伝子 / 中枢神絳 / 虚血 / 耐性誘導 / 高圧酸素 / 耐性関連因子 / Central nervous system / Ischemic tolerance / Hyperbaric oxygen / Genomic response / 鎮痛薬 / 痛覚 / Cerebral Metabolism / Analgesic / 局所脳血流量 / カルシウム蓄積 / Brain Ischemia / Local Cerebral Blood Flow / Ca Accumulation / Receptor Binding / エンフルレン麻酔 / 痙攣 / 血流 / エンフルレン / Enflurane anesthesia / Seizures / Brain metabolism / 敗血症性脳症 / 脳内モノアミン / セロトニン代謝回転 / サブスタンスP. / サブスタンスP / Septic encephalopathy / Brain monoamine / Serotonin turnover / Receptor binding
Less
Research Projects
(
19
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
脳虚血耐性発現におけるアデノシンの関与と効果的薬物投与法に関する研究
Principal Investigator
Principal Investigator
中木村 和彦
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
Investigation on therapeutic potentials of inducing ischemic tolerance against ischemic neuronal damage in the spinal cord
Principal Investigator
SAKABE Takefumi
Project Period (FY)
2002 – 2004
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
The mechanism of Blood-brain barrier disturbance after cardiopulmonary bypass in cardiovascular surgery
Principal Investigator
ISHIDA Kazuyoshi
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
The machanism of delayed motor neuron death after transient spinal cord ischemia
Principal Investigator
SAKABE Takefumi
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
Elucidation of Molecular and Neurobiological Mechanism in Pathophysiological Pain following Peripheral Injury
Principal Investigator
ISHIKAWA Toshizo
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
Effects of intrathecal or intra-cerebral ventricular midazolam on the tail flick and local cerebral and spinal metabolic responses to preripheral stimulation during isoflurane anesthesia and morphine-induced analgesia in the rat
Principal Investigator
Principal Investigator
NAKAKIMURA Kazuhiko
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
The pathogenesis and treatment of cerebral ischemia based on the mechanism of cytoskeletal changes
Principal Investigator
SAKABE Takefumi
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
Elucidation of Molecular Mechanisms of Pain : Role of PKC and NGF on spinal sensitization in the pathological state following peripheral tissue injury
Principal Investigator
ISHIKAWA Toshizo
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
A study on the mechanism and treatment during lucid interval in a rat model of acute subdural hematoma
Principal Investigator
Principal Investigator
NAKAKIMURA Kazuhiko
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
Experimental studies of pathophysiology and treatment of spinal cord ischemia
Principal Investigator
SAKABE Takefumi
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Yamaguchi University
胎児型および成体型ニコチン性アセチルコリン受容体に対する筋弛緩薬、麻酔薬の効果
Principal Investigator
大下 修造
Project Period (FY)
1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
麻酔学
Research Institution
Yamaguchi University
Involvement of receptor-mediated regulation of Ca channel and second messengers in pain transmission and modulation
Principal Investigator
ISHIKAWA Toshizoh
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
麻酔学
Research Institution
Yamaguchi University
The role of intracellular signal transducing system in hypoxia/ischemiainduced brain damage : Therapeutic values of mild hypothermia and drugs
Principal Investigator
SAKABE Takefumi
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
麻酔学
Research Institution
Yamaguchi University
各種心停止モデルにおける体外循環を用いた蘇生法の有効性に関する研究
Principal Investigator
DAIKAI Sadamitsu
Project Period (FY)
1990
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
麻酔学
Research Institution
Yamaguchi University
Pathophysiology and Treatment of Brain Ischemia
Principal Investigator
TAKESHITA Hiroshi
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
麻酔学
Research Institution
Yamaguchi University
Central nervous system effect of enflurane.
Principal Investigator
SAKABE Takefumi
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
麻酔学
Research Institution
Yamaguchi University
Effects of drugs modulating receptor function in the rat with septic encephalopathy.
Principal Investigator
ISHIKAWA Toshizoh
Project Period (FY)
1987 – 1988
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
麻酔学
Research Institution
Yamaguchi University
笑気の鎭痛作用及び耐性発生機序に関する研究
Principal Investigator
坂部 武史
Project Period (FY)
1986
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
麻酔学
Research Institution
Yamaguchi University
Studies on Effects of Analgesics in the Central Nervous System Using the Technique of Metabolic Mapping.
Principal Investigator
TAKESHITA Hiroshi
Project Period (FY)
1985 – 1986
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
麻酔学
Research Institution
Yamaguchi University
# of Projects (Dsc)
# of Projects (Asc)
1.
SAKABE Takefumi
(40035225)
# of Collaborated Projects:
15 results
# of Collaborated Products:
0 results
2.
ISHIKAWA Toshizoh
(90034991)
# of Collaborated Projects:
13 results
# of Collaborated Products:
0 results
3.
MATSUMOTO Mishiya
(60243664)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
4.
MAEKAWA Tsuyoshi
(60034972)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
5.
DAIKAI Sadamitsu
(10187164)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
FUKUDA Shirou
(70322245)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
SANO Takanobu
(40243670)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
TAKESHITA Hiroshi
(50034898)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
大下 修造
(60144945)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
筒井 俊徳
(00155417)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
KURODA Yasuhiro
(80234615)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
TSUKAHARA Masato
(20136188)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
FURUKAWA Syoei
(90159129)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
KAWATA Ryuuichi
(20263783)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
ISHIDA Kazuyoshi
(80314813)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
IIDA Yasuhiko
(90304485)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
NAKAI Akira
(60252516)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
MORIMOTO Yasuhiro
(60325230)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
NAGAI Ikuo
(30145536)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
MURAKAWA Toshisuke
(30201809)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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