USUKI Fusako 臼杵扶佐子

Researcher Number	50185013
Other IDs
Affiliation (Current)	2025: 鹿児島大学, ヒトレトロウイルス学共同研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 鹿児島大学, ヒトレトロウイルス学共同研究センター, 客員研究員 2015 – 2016: 国立水俣病総合研究センター, その他部局等, 部長 2012 – 2014: 国立水俣病総合研究センター, 臨床部, 部長 2006 – 2013: 国立水俣病総合研究センター, 臨床部, 室長 2008: 国立水俣病総合研究センター, 臨床部・理学診療科, 室長 1993 – 1995: 帝京大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Neurology / Neurology / Pathological medical chemistry Except Principal Investigator Environmental pharmacy / Basic Section 64010:Environmental load and risk assessment-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Neurology / Environmental and hygienic pharmacy / Neurology
Keywords	Principal Investigator NMD抑制 / siRNA / PTC / collagen VI / 細胞増殖 / Nonsense-mediated mRNA decay(NMD) / NMD構成分子 / 細胞移入 / 筋芽細胞 / acid α-glucosidase(GAA) … More / 糖原病II型 / Ullrich's disease / molesular therapy / nonsense mutation / frame-shift mutation / hSMG-1 / hUpf1 / molecular therapy / collagenVI / Ullrich病 / premature translation termination codon(PTC) / nonsense-mediated mRNA decay(NMD) / Therapy / Transfer / Myoblast / Acid alpha-glucosidase (GAA) / Glycogenosis type II / GAA前駆体 / acidalpha-glucosidase(GAA) / 治療 / ストレス蛋白質 / GAS5 / 早期終止コドン / Snhg1 / 蛋白質翻訳 / mTOR pathway / 小胞体ストレスプレコンディショニング / 早期終止コドン (PTC) / eIF2α リン酸化 / Snhg1 mRNA / 蛋白質翻訳抑制 / 早期終止コドン(PTC) / eIF2αリン酸化 / mRNA監視機構(NMD) / 環境ストレス / SMG-7 / SMG-1 / Upf1 / グルタチオンペルオキシダーゼ1 / セレノプロテイン / セレノシステイン / nonsense-mediated mRNA decay NMD / SMG-8 / HeLa細胞 / ノックダウン / 生体ストレス応答 / 細胞生理機能 / 腫瘍細胞 / Ullrich病繊維芽細胞 / siRNA, NMD抑制 / Nonsense-mediated mRNA decay (NMD) / 遺伝子治療 / cDNA … More Except Principal Investigator メチル水銀 / 神経機能障害 / Dp116 / DRP / 小脳 / 水俣病 / 中毒学 / miRNA / エクソソーム / ポリチオール化 / バイオマーカー / 振動刺激 / 筋線維 / 神経軸索 / 振動刺激処置 / ROCK阻害剤 / 神経障害性疼痛 / 筋機能障害 / SIALIC ACID / LAMININ / DYSTROGLYCAN COMPLEX / SCHWANN CELL / UTROPHIN / DYSTROPHIN EXPRESSION FACTOR / 治療法 / Duchenne型筋ジストロフィー / Dystrophin associated proteins / 非筋細胞 / DRP upregulation / DMD治療 / シアル酸 / laminin / dystroglycan complex / Schwann cell / utrophin / dystrophin expression factor / シナプス蛋白 / 神経突起 / 神経症状 / 胎児期曝露 / 低濃度メチル水銀 / ラット / VEGF / 血液脳関門 / 血管内皮細胞増殖因子 / メチル水銀中毒 / 薬学 / 環境系薬学 / 選択的神経細胞障害 / フランス / 国際情報交換 / 小脳顆粒細胞 / マイクロダイセクション / 薬理学 / 脳神経疾患 / 再生医学 / 環境 / ローキナーゼ阻害薬 / 環境毒 Less

Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoning
- Principal Investigator
  
  藤村成剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 64010:Environmental load and risk assessment-related
- Research Institution
  National Institute for Minamata Disease
Experimental research on regenerative treatment of axon and muscle fiber for nerve and muscle dysfunction by methylmercury
- Principal Investigator
  
  Fujimura Masatake
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute for Minamata Disease
Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal period
- Principal Investigator
  
  Fujimura Masatake
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute for Minamata Disease
Research on environmental stresses-induced change in nonsense-mediated mRNA decay (NMD) activity and its effect on pathological conditionsPrincipal Investigator
- Principal Investigator
  
  Usuki Fusako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Institute for Minamata Disease
Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoning
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Experimental research on selective neuronal damage by methylmercury using microdissection method
- Principal Investigator
  
  FUJIMURA Masatake
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute for Minamata Disease
Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxins
- Principal Investigator
  
  FUJIMURA Masatake
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Institute for Minamata Disease
Research on the pathophysiology and treatment of neurological disorders modified by nonsense-mediated mRNA decay (NMD)Principal Investigator
- Principal Investigator
  
  USUKI Fusako
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Institute for Minamata Disease
Research on the therapeutic approach targeting an mRNA quality-control in herediatry neurological disordersPrincipal Investigator
- Principal Investigator
  
  USUKI Fusako
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Institute for Minamata Disease
α-グルコシダーゼcDNA導入細胞を用いた糖原病II型の遺伝子治療Principal Investigator
- Principal Investigator
  
  臼杵扶佐子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Teikyo University
DEVELOPMENT OF A THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY BY DRPUPREGULATION
- Principal Investigator
  
  SHINIZU Teruo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  TEIKYO UNIVERSITY
Therapy of glycogenosis type II by myoblast transferPrincipal Investigator
- Principal Investigator
  
  USUKI Fusako
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Teikyo University

[Book] Handbook of Neurotoxicity2021
- Author(s)
  Fujimura M, Usuki F
- Total Pages
  16
- Publisher
  Springer, Cham
- ISBN
  9783030715199
- Data Source
  KAKENHI-PROJECT-19K07077
[Book] 実験医学増刊「拡大・進展を続けるRNA研究の最先端」(塩見春彦、塩見美喜子、稲田利文、廣瀬哲郎編集)2010
- Author(s)
  山下暁朗、臼杵扶佐子
- Total Pages
  205
- Publisher
  mRNA監視機構の生命現象、疾患への寄与とその分子機構
- Data Source
  KAKENHI-PROJECT-20591015
[Book] mRNA監視機構の生命現象、疾患への寄与とその分子機構.実験医学増刊「拡大・進展を続けるRNA研究の最先端」(塩見春彦、塩見美喜子、稲田利文、廣瀬哲郎編集)2010
- Author(s)
  山下暁朗、臼杵扶佐子
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20591015
[Book] NMDによるmRNA排除と疾患-----難治性遺伝性疾患治療への試み.蛋白質・核酸・酵素増刊mRNAプログラム多様性と非対称性の獲得戦略(稲田利文、大野睦人編集)2009
- Author(s)
  山下暁朗、臼杵扶佐子
- Publisher
  共立出版, 東京
- Data Source
  KAKENHI-PROJECT-20591015
[Book] Signal transduction systems involved in methylmercury-cytotoxicity. (In : Aschner M and Ceccatelli S (ed.))
- Author(s)
  Usuki F, Fujimura M
- Publisher
  Springer Science + Business Media, Berlin
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Cellular conditions responsible for methylmercury-mediated neurotoxicity.2022
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 13 Pages: 7218-7218
- DOI
  10.3390/ijms23137218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Methylmercury induces hyperalgesia/allodynia through spinal cord dorsal horn neuronal activation and subsequent somatosensory cortical circuit formation in rats2021
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Journal Title
  
  Archives of Toxicology
  
  Volume: 95 Issue: 6 Pages: 2151-2162
- DOI
  10.1007/s00204-021-03047-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Local Vibration Stimuli Induce Mechanical Stress-Induced Factors and Facilitate Recovery From Immobilization-Induced Oxidative Myofiber Atrophy in Rats2019
- Author(s)
  Usuki F, Fujimura M, Nakamura A, Nakano J, Okita M, Higuchi I
- Journal Title
  
  Front Physiol
  
  Volume: 10 Pages: 759-759
- DOI
  10.3389/fphys.2019.00759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Fasudil, a Rho-Associated Coiled Coil-Forming Protein Kinase Inhibitor, Recovers Methylmercury-Induced Axonal Degeneration by Changing Microglial Phenotype in Rats2019
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Journal Title
  
  Toxicol Sci
  
  Volume: 168 Issue: 1 Pages: 126-136
- DOI
  10.1093/toxsci/kfy281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07077
[Journal Article] Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity adn eEF1A1 expression in the rat cerebellum.2016
- Author(s)
  Fujimura M, Usuki F, Cheng J, Zhao W
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 298 Pages: 1-8
- DOI
  10.1016/j.taap.2016.03.002
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity2016
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Journal Title
  
  Archives of Toxicology
  
  Volume: unknown Issue: 4 Pages: 917-26
- DOI
  10.1007/s00204-015-1528-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460402
[Journal Article] Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3β and subsequent degradation of cyclin E in rats.2015
- Author(s)
  Fujimura M, Usuki F.
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 288 Issue: 1 Pages: 19-25
- DOI
  10.1016/j.taap.2015.07.006
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators.2015
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 282 Issue: 3 Pages: 259-266
- DOI
  10.1016/j.taap.2014.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460187
[Journal Article] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2014
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Arch. Toxicol
  
  Volume: 89 Pages: 109-113
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2014
- Author(s)
  Fujimura M, Usuki F
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 88 Issue: 1 Pages: 109-113
- DOI
  10.1007/s00204-013-1089-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590167
[Journal Article] Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses.2013
- Author(s)
  Usuki F, Fujimura M, Yamashita A
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 2346-2346
- DOI
  10.1038/srep02346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-25460402
[Journal Article] Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.2013
- Author(s)
  Usuki F, Yamashita A, Shiraishi T, Shiga A, Onodera O, Higuchi I, Ohno S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Issue: 37 Pages: 15037-42
- DOI
  10.1073/pnas.1300654110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23112003, KAKENHI-PROJECT-23687025, KAKENHI-PROJECT-25460402
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S
- Journal Title
  
  Toxicol Appl Pharm
  
  Volume: 250 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S
- Journal Title
  
  Toxicol. Appl.Pharmacol. 250
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S.
- Journal Title
  
  Toxicol.Appl.Pharmacol.
  
  Volume: 250 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.2011
- Author(s)
  Usuki F, Yamashita A, Fujimum M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 6641-6649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methyl-mercury exposure.2011
- Author(s)
  Fujimura M, Usuki F, Kawamura M, Izumo S
- Journal Title
  
  Toxicol Appl Pharm 250
  
  Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Posttranscriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.2011
- Author(s)
  Usuki F, Yamashita A, Fujimura M
- Journal Title
  
  J Biol Chem 286
  
  Pages: 6641-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Nonsense-mediated mRNA decay(NMD)による変異mRNA排除と疾患2010
- Author(s)
  臼杵扶佐子、山下暁朗
- Journal Title
  
  細胞工学 29
  
  Pages: 155-160
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] NMDによる変異mRNA排除と疾患2010
- Author(s)
  臼杵扶佐子、山下暁朗
- Journal Title
  
  細胞工学 19
  
  Pages: 155-160
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Methylmercury exposure down- regulates the expression of Rac l and leads to neuritic degeneration and ultimately apoptosis incerebrocortical neurons.2009
- Author(s)
  Fujimura M, Usuki F, Sawada M, Rostene W, Godefroy D, Takashima, A
- Journal Title
  
  NeuroToxicology 30
  
  Pages: 16-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons2009
- Author(s)
  Masatake Fujimura, Fusako Usuki, Masumi Sawada, William Rostene, David Godefroy, Akihiko Takashima
- Journal Title
  
  Neurotoxicology 30
  
  Pages: 16-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] Methylmercury exposure downregulates the expression of Racl, leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons.2009
- Author(s)
  Fujimura M, Usuki F, Sawada M, Rostene W, Godefroy D, Takashima A
- Journal Title
  
  Neurotoxicology 30
  
  Pages: 16-22
- Data Source
  KAKENHI-PROJECT-20590135
[Journal Article] NMDによるmRNA排除と疾患…難治性遺伝性疾患治療への試み.2009
- Author(s)
  山下暁朗、臼杵扶佐子
- Journal Title
  
  蛋白質・核酸・酵素増刊
  
  Pages: 2219-2225
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of c-jun-N-terminal kinase pathway in the cerebral cortex, but not inthe hippocampus of the mouse brain.2009
- Author(s)
  Fujimura M, Usuki F, Sawada M, Takashima A
- Journal Title
  
  NeuroToxicology 30
  
  Pages: 1000-1007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591015
[Journal Article] Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upfl, rescues the phenotype of Ullrich's disease fibroblasts2006
- Author(s)
  Usuki F, Yamashita A, Kashima I, Higuchi I, Osame M, Ohno S
- Journal Title
  
  Molecular Therapy 14
  
  Pages: 351-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Journal Article] A novel therapeutic approach for genetic diseases by introduction introduction of suppressor tRNA2006
- Author(s)
  Sako Y, Usuki F, Suga H
- Journal Title
  
  Nucleic Acids Symposium(Ser) 50
  
  Pages: 239-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Journal Article] Specific inhibition of nonsense-mediated mRNA decay has the potential to rescue the phenotype of muscular dystrophy2006
- Author(s)
  Usuki F
- Journal Title
  
  Clinical Neurology 46
  
  Pages: 939-41
- NAID
  10020347592
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590969
[Journal Article] A novel therapeutic approach for genetic diseases by introduction of suppressor tRNA2006
- Author(s)
  Sako Y, Usuki F, Suga H
- Journal Title
  
  Nucleic Acids Symposium (Ser) 50
  
  Pages: 239-40
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590969
[Journal Article] Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich's disease fibroblasts2006
- Author(s)
  Usuki F, Yamashita A, Kashima I, Higuchi I, Osame M, Ohno S
- Journal Title
  
  Molecular Therapy 14
  
  Pages: 351-60
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] メチル水銀曝露ラットに生じる疼痛閾値低下に対する各種薬剤の効果2023
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤
- Organizer
  令和5年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Methylmercury induces allodynia through activation of inflammatory microglia in spinal cord and subsequent stimulation in somatosensory cortex od rats2021
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Organizer
  60th Annual Meeting, Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] メチル水銀曝露はラット足底部に神経障害性疼痛の1種である疼痛閾値低下 (アロディニア) を引き起こす2020
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] 局所振動刺激はラットにおいてメカノストレス因子を誘導し不動化による筋萎縮からの回復を促進する2019
- Author(s)
  藤村成剛, 臼杵扶佐子, 中村篤, 中野治郎, 沖田実, 樋口逸郎
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Fasudil, a ROCK inhibitor, recovers methylmercury-induced axonal degeneration by changing microglial phenotype in rats2019
- Author(s)
  Fujimura M, Usuki F, Nakamura A
- Organizer
  14th International Conference on Mercury as a Global Pollutant
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07077
[Presentation] Mild endoplasmic reticulum stress preconditioning upregulates gene expression of membrane transporters.2016
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Organizer
  55th Annual Meeting of Society of Toxicology
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] メチル水銀中毒バイオマーカーとしての血漿チオール抗酸化バリアとセレノ蛋白質.2016
- Author(s)
  臼杵扶佐子、藤村成剛
- Organizer
  メチル水銀ミーテイング
- Place of Presentation
  東京
- Year and Date
  2016-01-07
- Invited
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure.2015
- Author(s)
  Fujimura M, Usuki F.
- Organizer
  ASIATOX 2015
- Place of Presentation
  韓国・済州
- Year and Date
  2015-06-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] Methylmercury-induced stress responses in astroglia cells2015
- Author(s)
  Fusako Usuki, Masatake Fujimura
- Organizer
  Society of Toxicology 54th Annual Meeting
- Place of Presentation
  SanDiego, USA
- Year and Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] 低用量メチル水銀のラット胎児期曝露はTrkA-eEF1A1経路の抑制を介して神経突起形成不全およびシナプス恒常性変化を引き起こす.2015
- Author(s)
  藤村成剛, 臼杵扶佐子.
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] 小胞体ストレスプレコンディショニングによるメチル水銀毒性防御2014
- Author(s)
  臼杵扶佐子
- Organizer
  平成26年度メチル水銀ミーティング
- Place of Presentation
  東京
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-25460402
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第25回日本脳循環代謝学会総会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第54 回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] Low in situ expression of antioxidative enzymes in rat cerebellar granular cells susceptible to methylmercury2013
- Author(s)
  Fujimura M, Usuki F
- Organizer
  第36回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23590167
[Presentation] Posttranscriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.2011
- Author(s)
  臼杵扶佐子
- Organizer
  NIMD FORUM 2011
- Place of Presentation
  Minamata, Jan
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Posttranscriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure.2011
- Author(s)
  Usuki F
- Organizer
  NIMD FORUM 2011
- Place of Presentation
  Minamata
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Methylmercury exposure downregulates the expression of Racl, leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons.2010
- Author(s)
  Fujimura M, Usuki F, Rostene W, Godefroy D, Takashima A
- Organizer
  48^<th> Society of Toxicology's annual meeting
- Place of Presentation
  Salt Lake City, USA
- Year and Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-20590135
[Presentation] メチル水銀による酸化ストレス発生2010
- Author(s)
  臼杵扶佐子
- Organizer
  北陸大学サテライトミーティング
- Place of Presentation
  水俣
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] メチル水銀による酸化ストレス発生2010
- Author(s)
  臼杵扶佐子
- Organizer
  北陸大学学術フロンティア・サテライトミーティング
- Place of Presentation
  水俣
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mousebrain.2010
- Author(s)
  Fujimura M, Usuki F, Takashima A
- Organizer
  XVII^<th> International Congress of Neuropathology
- Place of Presentation
  Austria, Salzburg
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Methylmercury causes oxidative stress through its posttranscriptional effect on antioxidant selenoenzymes.2010
- Author(s)
  Usuki F, Yamashita A, Fujimura M
- Organizer
  XVII^<th> International Congress of Neuropathology
- Place of Presentation
  Austria, Salzburg
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain.2010
- Author(s)
  Fujimura M, Usuki F, Takashima A
- Organizer
  XVIIt^<th> International Congress of Neuropathology
- Place of Presentation
  Austria, Salzburg
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Disease conditions associated with nonsense-mediated mRNA decay (NMD)シンポジウム「ナンセンス変異と疾患2009
- Author(s)
  臼杵扶佐子
- Organizer
  mRNAサーベイランス機構NMDを介した疾病発症のメカニズムと新規治療薬」第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Disease conditions associated with nonsense-mediated mRNA decay (NMD)2009
- Author(s)
  臼杵扶佐子
- Organizer
  第82回日本薬理学会年会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-20591015
[Presentation] Ullrich病細胞機能を回復させるNMD(nonsense-mediated-mediated mRNA decay)抑制分子的探索2007
- Author(s)
  臼杵扶佐子、山下暁朗、樋口逸郎、大野茂男
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Search for nonsense-mediated mRNA decay(NMD) components, specific inhibition of which rescues effectively the phenotype of genetic diseases exacerbated by NMD2007
- Author(s)
  Usuki F, Yamashita A, Higuchi J, Ohno S
- Organizer
  48th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Ullrich病細胞機能を回復させるNMD(nonsense-mediated mRNA decay)抑制分子の探索2007
- Author(s)
  臼杵扶佐子、山下暁朗、樋口逸郎、大野茂男
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] サプレッサーtRNAの導入による遺伝性疾患の新規治療法の開発2006
- Author(s)
  佐古祐介、臼杵扶佐子、菅裕明
- Organizer
  第33回核酸化学シンポジウム
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Symposium on New Strategy for the Therapy of Muscular Dystrophy Specific inhibition of nonsense-mediated mRNA decay has the potential to rescue the phenotype of muscular dystrophy2006
- Author(s)
  Usuki F
- Organizer
  47th Annual Meeting of the Japanese Society of Neurology
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] シンポジウム筋ジストロフィー治療の新戦略: Nonsense-mediated mRNA decay(NMD)を標的とした治療の可能性2006
- Author(s)
  臼杵扶佐子
- Organizer
  第47回日本神経学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] A novel therapeutic approach for genetic diseases by introduction of suppressor tRNA2006
- Author(s)
  SakoY,Usuki F, Suga H
- Organizer
  33rd Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Inhibition of nonsense-mediated mRNA decay rescues the phenotype of Ullrich's disease fibroblasts.2006
- Author(s)
  Yamashita A, Usuki F, Kashima I, Izumi N, Higuchi I, Osame M, Ohno S
- Organizer
  8th Annual Meeting of the RNA Society of Japan
- Place of Presentation
  Awaji
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Inhibition of nonsense-mediated mRNA decay rescues the phenotype of Ullrich's disease fibroblasts2006
- Author(s)
  Yamashita A, Usuki F, Kashima I, Izumi N, Higuchi I, Osame M, Ohno S
- Organizer
  第8回日本RNA学会
- Place of Presentation
  淡路
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590969
[Presentation] Vascular endothelial growth factor upregulation in blood brain barrier in rat models of subacute methylmercury intoxication
- Author(s)
  Tetsuya Takahashi, Masatake Fujimura, Fusako Usuki, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  65th American Academy of Neurology Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子（VEGF）発現の検討
- Author(s)
  高橋　哲哉、藤村成剛、臼杵扶佐子、西澤正豊、下畑享良
- Organizer
  第53回神経学会学術集会
- Place of Presentation
  東京・国際フォーラム
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] Activation of TrkA pathway by GM1 ganglioside and its analog prevents methylmercury-induced nerve damage in vitro and in vivo.
- Author(s)
  Fujimura M, Usuki F
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460187
[Presentation] Low level of methylmercury inhibits cell proliferation through the activation of glycogen synthase kinase 3and subsequent degradation of cyclin E in cortical progenitor cells of rats.
- Author(s)
  Fujimura M, Usuki F
- Organizer
  54th Society of Toxicology
- Place of Presentation
  米国・サンディエゴ
- Year and Date
  2015-03-22 – 2015-03-26
- Data Source
  KAKENHI-PROJECT-26460187

1. FUJIMURA Masatake (20416564)

# of Collaborated Projects: 7 results

# of Collaborated Products: 34 results
2. YAMASHITA Akio (20405020)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. SHINIZU Teruo (00107666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IZUMO Shuji (30143811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SHIMOHATA Takayoshi (60361911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. TAKAHASHI Tetsuya (20515663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. YAMADA Hiroki (90260926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUMURA Kiichiro (50260922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石浦章一 (10158743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 樋口逸郎 (80183573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中村篤 (40785713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. 鵜木隆光 (00742868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中村政明 (50399672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤田幸子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大野茂男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

USUKI Fusako 臼杵 扶佐子

Research Projects

Research Products

Co-Researchers

Development of a biomarker that can objectively determine differences in individual susceptibility to methylmercury poisoning

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Experimental research on regenerative treatment of axon and muscle fiber for nerve and muscle dysfunction by methylmercury

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Research on inciting factor of neurological symptoms following low dose methylmercury exposure in fetal period

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Research on environmental stresses-induced change in nonsense-mediated mRNA decay (NMD) activity and its effect on pathological conditionsPrincipal Investigator

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Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoning

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Experimental research on selective neuronal damage by methylmercury using microdissection method

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Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxins

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Research on the pathophysiology and treatment of neurological disorders modified by nonsense-mediated mRNA decay (NMD)Principal Investigator

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Research on the therapeutic approach targeting an mRNA quality-control in herediatry neurological disordersPrincipal Investigator

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α-グルコシダーゼcDNA導入細胞を用いた糖原病II型の遺伝子治療Principal Investigator

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DEVELOPMENT OF A THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY BY DRPUPREGULATION

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Therapy of glycogenosis type II by myoblast transferPrincipal Investigator

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[Book] Handbook of Neurotoxicity2021

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USUKI Fusako 臼杵扶佐子

[Book] NMDによるmRNA排除と疾患-----難治性遺伝性疾患治療への試み.蛋白質・核酸・酵素増刊mRNAプログラム多様性と非対称性の獲得戦略(稲田利文、大野睦人編集)2009