Miyazawa Keisuke 宮澤啓介

… Alternative Names

MIYAZAWA Keisuke 宮澤啓介

宮沢啓介ミヤザワケイスケ

宮澤啓介ミヤザワケイスケ

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Researcher Number	50209897
Other IDs
External Links
Affiliation (Current)	2025: 東京医科大学, 医学部, 主任教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 東京医科大学, 医学部, 主任教授 2017: 東京医科大学, 医学部, 准教授 2017: 東京医科大学, 医学部, 教授 2014 – 2015: 東京医科大学, 医学部, 教授 2010 – 2012: 東京医科大学, 医学部, 教授 … More 2007: Tokyo Medical University, School of Medicine, Associate Professor 2006: 東京医科大学, 医学部, 助教授 1997 – 2003: 東京医科大学, 医学部, 講師 1996: 東京医科大学, 医学部, 助手 1994: 東京医科大学, 内科第1講座, 助手 1993 – 1994: 東京医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Experimental pathology / Hematology Except Principal Investigator Hematology / Applied pharmacology / Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / General surgery / Neurology / Gastroenterology
Keywords	Principal Investigator アポトーシス / 白血病 / オートファジー / apoptosis / leukemia / vitamin K2 / ビタミンK2 / プロテアソーム / 小胞体ストレス / c-kit … More / 造血 / vitamin D3 / differentiation / 分化 / 骨髄異形成症候群 / ボルテゾミブ / アグリソーム / 多発性骨髄腫 / 腫瘍 / マクロライド系抗生剤 / cell death / bcl-2 / autophagy / 細胞死 / 急性骨髄性白血病 / p21CIP1 / cell cycle / myelodysplastic syndrome / 急性白血病 / ビタミンD3 / 細胞周期 / myelodysplastic syndromes / Hematopoietic growth factor / Differentiation-inducing therapy / Leukemia / Cytokine / Differentiation / Cell Growth / Hematopoiesis / 分化誘導療法 / 細胞分化 / 細胞増殖 / サイトカイン / 造血因子 / ヒストン脱アセチル化酵素６ / マクロライド化合物 / プロテアソーム阻害剤 / マクロライド抗生剤 / ユビキチン / 細胞保護効果 / 慢性骨髄性白血病 / メシル酸イマチニブ / チロシンキナーゼ / SCF / Steel Factor / トロンボポイエチン / 巨核球 / stromal cell / phoshporylation / tyrosine kinase / receptor / Steel factor / polybiquitination / ubiquitin / steel factor / 受容体 … More Except Principal Investigator オートファジー / アポトーシス / マクロライド / 小胞体ストレス / ルキソリチニブ / 原発性骨髄線維症 / myelofibrosis / calreticulin / macrolide / ruxolitinib / primary myelofibrosis / Apoptosis / Vitamin K2 / ERストレス / ネクロプトーシス / 分子標的治療 / 薬物治療学 / ＥＧＦＲ　ＴＫＩ / アミノ酸トランスポーター / マクロライド系抗菌薬 / 分子標的薬 / マクロライド抗生剤 / がん / 頭頸部腫瘍 / EGFR-TKI / アミノ酸 / マクロライド抗菌薬 / 頭頸部癌 / JAK阻害薬 / UT7/TPO / proteasome inhibitor / ER stress / bortezomib / UT-7 / プロテアソーム阻害薬 / 骨髄増殖性腫瘍 / autophagy / thrombopietin / thrombopoietin / Myelodysplastic Syndrome / Leukemia / MDS / 骨髄異形成症候群 / 白血病 / ビタミンK2 / アグリゾーム / 微小管 / リソソーム / プロテアソーム / アグリソーム / 乳癌 / 頸動脈プラ－ク / Beclin-1 / オ－トファジ－ / ＴＤＰ-43 / アルツハイマ－病 / Beclin 1 / 筋萎縮性側索硬化症 / オートファジ－ / リン酸化TDP43 / 頸動脈 / 血栓 / レビ－小体型認知症 / 脳梗塞 / Ｂｅｃｌｉｎ1 / ＨＭＧＢ1 / １４－３－３蛋白 / 神経細胞死 / Beclin1 / HMGB1 / 14-3-3蛋白 / Drug Delivery System / ナノ粒子 / 膵癌 / チロシンキナーゼ阻害剤 / 膵臓癌 / マクロライド化合物 / 上皮成長因子受容体 / BCRIABL / Ph陽性白血病 Less

Novel ER stress-mediated therapy for tumor clones in myelofibrosis
- Principal Investigator
  
  Gotoh Akihiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
  Juntendo University
A novel therapeutic method for multiple myeloma by comprehensive control of intracellular protein degradation mechanismPrincipal Investigator
- Principal Investigator
  
  Miyazawa Keisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Establishment of novel "amino acid starvation induction therapy" using macrolide antibiotics for head and neck cancer
- Principal Investigator
  
  Hirasawa Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University
Selective elimination of tumor clones of primary myelofibrosis based on drug repositioning
- Principal Investigator
  
  Gotoh Akihiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Juntendo University
ER-stress loading therapy in refractory multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Miyazawa Keisuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Medical University
Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1
- Principal Investigator
  
  Umahara Takahiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University
ER stress intoroduce an innovative therapy for metastatic breast cancer.
- Principal Investigator
  
  Komatsu Seiichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Tokyo Medical University
Establishment of the biomarker with nanoparticles for the diagnosis and the treatment of pancreatic cancer
- Principal Investigator
  
  ITOI Takao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
Targeting tyrosine kinases for autophagy induction along with cytoprotective effect in hematopoietic progenitor cellsPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Regulatory mechanism between autophagy and apoptosis in leukemia cellsPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Establishment of Vitamin K2 Therapy in Myelodysplastic SyndromesPrincipal Investigator
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Effects of Vitamin K2 in Patients with Myelodysplastic Syndromes-From The Standing Point of Apoptosis Inducing Effects of Vitamin K2 on Leukemia Cells-Principal Investigator
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Examination of apoptosis-inducing activity in leukemia cells by vitamin K2 and the clinical application of vitamin K2
- Principal Investigator
  
  YAGUCHI Makoto
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Hematopoietic Cell Maturation Is Regulated by Maintaining a Balance against Cytokine Induced-Cell Proliferation - Clinical Application for Differentiation-inducing Therapy of Leukemia-Principal Investigator
- Principal Investigator
  
  MIYAZAWA Keisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
巨核球形成における膜結合型及び分泌型Steel Factorの生物学的比較検討Principal Investigator
- Principal Investigator
  
  宮澤啓介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Ph'陽性急性白血病の生物学的意義とその集学的治療に関する研究
- Principal Investigator
  
  外山圭助
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
膜結合型及び分泌型Steel FactorによるC-KIT活性化の生物学的検討Principal Investigator
- Principal Investigator
  
  宮沢啓介
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
c-kit遺伝子産物におけるpolyubiquitinationの生物学的意義-Steel factor刺激後のc-kit蛋白のturnoverに及ぼす影響-Principal Investigator
- Principal Investigator
  
  宮澤啓介
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University

[Book] 造血器腫瘍の発生機構:好酸球増加症候群(HES), 慢性好酸球性白血病(CEL)で見出された新規FIPIL1-PDGFRA融合遺伝子, 造血器腫瘍アトラス2008
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  日本医事新報社(in press)
- Data Source
  KAKENHI-PROJECT-18591089
[Book] DNAメチル化阻害剤みんなに役立つ骨髄異形成症候群の基礎と臨床2008
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  医薬ジャーナル
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] DNAメチル化阻害剤みんなに役立つ骨髄異形成症候群の基礎と臨床2008
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  医薬ジャーナル(in press)
- Data Source
  KAKENHI-PROJECT-18591089
[Book] 造血器腫瘍の発生機構:好酸球増加症候群(HES), 慢性好酸球性白血病(CEL)で見出された新規FIPIL1-PDGFRA融合遺伝子, 造血器腫瘍アトラス2008
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  日本医事新報社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] 疾患別移植の適応のガイドライン:骨髄異形成症候群, 造血幹細胞移植のすべて2007
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  科学評論社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] 骨髄不全症における輸血依存性鉄過剰症の病態-iron overloadと鉄キレート療法-2007
- Author(s)
  宮澤啓介(分担執筆)
- Total Pages
  216
- Publisher
  メディカルレビュー
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] 骨髄異形成症候群-治療効果判定基準-:造血器腫瘍取り扱い規約2007
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  金原出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] 骨髄異形成症候群-予後予測因子-:造血器腫瘍取り扱い規約2007
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  金原出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] AMLの化学療法中に白血球が低下し感染症が起きた。G-CSFは使用してよいのか。さてどうしよう?造血器腫瘍治療-これは困ったぞ, どうしよう!2006
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Book] Myeloid antigen陽性ALLでG-CSFは使用してよいのか。さてどうしよう?造血器腫瘍治療-これは困ったぞ, どうしよう!2006
- Author(s)
  宮澤啓介(分担執筆)
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin2020
- Author(s)
  Tanaka Hideki、Hino Hirotsugu、Moriya Shota、Kazama Hiromi、Miyazaki Masaya、Takano Naoharu、Hiramoto Masaki、Tsukahara Kiyoaki、Miyazawa Keisuke
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 22 Pages: 100750-100750
- DOI
  10.1016/j.bbrep.2020.100750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-17K15031
[Journal Article] Abemaciclib induces atypical cell death in cancer cell characterized by formation of cytoplasmic vacuoles derived from lysosomes2020
- Author(s)
  Hino Hirotsugu, Iriyama Noriyoshi, Kokuba Hiroko, Kazama Hiromi, Moriya Shota, Takano Naoharu, Hiramoto Masaki, Aizawa Shin, Miyazawa Keisuke
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 6 Pages: 2132-2145
- DOI
  10.1111/cas.14419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-20K08970, KAKENHI-PROJECT-18K06846, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-17K15031
[Journal Article] Association of BRCA Mutantations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines2020
- Author(s)
  Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T.
- Journal Title
  
  J Surg Res.
  
  Volume: 250 Pages: 200-208
- DOI
  10.1016/j.jss.2019.12.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-17K15031
[Journal Article] Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines2019
- Author(s)
  Miyazawa Shinsuke、Moriya Shota、Kokuba Hiroko、Hino Hirotsugu、Takano Naoharu、Miyazawa Keisuke
- Journal Title
  
  Breast Cancer
  
  Volume: 27 Issue: 2 Pages: 225-235
- DOI
  10.1007/s12282-019-01012-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-17K15031
[Journal Article] Fingolimod/FTY720 sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest.2019
- Author(s)
  Ohta　K, Ohkuma T, Lorenzo AD, Yokota A, Hino H, Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K.
- Journal Title
  
  Oncol Rep.
  
  Volume: - Pages: 231-242
- DOI
  10.3892/or.2019.7140
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-18K15031, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-19K07107, KAKENHI-PROJECT-17K15031
[Journal Article] Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis.2018
- Author(s)
  Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi　H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume: 52 Pages: 1165-1177
- DOI
  10.3892/ijo.2018.4282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-17K15031
[Journal Article] Designing an effective drug combination for ER stress loading in cancer therapy　using a real-time monitoring system2018
- Author(s)
  Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: - Issue: 1 Pages: 286-292
- DOI
  10.1016/j.bbrc.2018.05.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K06901, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K21388, KAKENHI-PROJECT-17K15031
[Journal Article] A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.2018
- Author(s)
  Hiramoto M, Udagawa H, Ishibashi N, Takahashi E, Kaburagi Y, Miyazawa K, Funahashi N, Nammo T, Yasuda K.
- Journal Title
  
  International Journal of Molecular Medicine
  
  Volume: 41(2) Pages: 717-728
- DOI
  10.3892/ijmm.2017.3273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13237, KAKENHI-PROJECT-17K08771
[Journal Article] The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells.2017
- Author(s)
  Iriyama N, Hino H, Moriya S, Hiramoto M, Hatta Y, Takei M, Miyazawa K.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: 18 Issue: 6 Pages: 1-12
- DOI
  10.1080/10428194.2017.1376741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08771, KAKENHI-PROJECT-16K19187
[Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.2016
- Author(s)
  Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 1 Pages: 45-54
- DOI
  10.3892/ijo.2015.3237
- NAID
  120005845877
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-26460478, KAKENHI-PLANNED-23102002, KAKENHI-PUBLICLY-26102737, KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21388
[Journal Article] Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.2016
- Author(s)
  Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M.
- Journal Title
  
  Sci Rep.
  
  Volume: 18 Issue: 1 Pages: 35599-35599
- DOI
  10.1038/srep35599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K08937, KAKENHI-PROJECT-16K09219, KAKENHI-PROJECT-26460809, KAKENHI-PROJECT-16K19187
[Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016
- Author(s)
  Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K,Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K.
- Journal Title
  
  Int J Oncol.
  
  Volume: 49 Issue: 5 Pages: 1848-1858
- DOI
  10.3892/ijo.2016.3673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387
[Journal Article] Macrolide antibiotics exhibit cytotoxiceffect under amino acid-depleted culture condition by blocking autophagy flux in head and neck squamous cell carcinoma cell lines.2016
- Author(s)
  Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu　M, Hiramoto M, Tsukahara K, Miyazawa K.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 12 Pages: 1848-1858
- DOI
  10.1371/journal.pone.0164529
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K19187, KAKENHI-PROJECT-16K21387, KAKENHI-PROJECT-16K21388
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).2016
- Author(s)
  Klionsky DJ, Abdelmohsen K, Abe A, Miyazawa K et al.
- Journal Title
  
  Autophagy
  
  Volume: 12 Pages: 1-222
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460478
[Journal Article] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.2015
- Author(s)
  Sugita S, Ito K, Yamashiro Y, Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: Apr 7 Issue: 1 Pages: 28-34
- DOI
  10.1016/j.bbrc.2015.03.162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-15K07972
[Journal Article] Comparative analysis of type 2 diabetes-associated SNP alleles identifies allele-specific DNA-binding proteins for the KCNQ1 locus.2015
- Author(s)
  Hiramoto M, Udagawa H, Watanabe A, Miyazawa K, Ishibashi N, Kawaguchi M, Uebanso T, Nishimura W, Nammo T, Yasuda K.
- Journal Title
  
  Int J Mol Med.
  
  Volume: 36 Issue: 1 Pages: 222-2230
- DOI
  10.3892/ijmm.2015.2203
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26461352
[Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells.2015
- Author(s)
  Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
- Journal Title
  
  Int J Oncol.
  
  Volume: Feb;46(2) Issue: 2 Pages: 474-86
- DOI
  10.3892/ijo.2014.2773
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860398, KAKENHI-PROJECT-26430170, KAKENHI-PROJECT-26460478, KAKENHI-PROJECT-26670589, KAKENHI-PROJECT-15K07972
[Journal Article] Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells2013
- Author(s)
  Moriya S, Che XF, Komatsu S, Abe A,Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K
- Journal Title
  
  Int J Oncol
  
  Volume: 42 Issue: 5 Pages: 1541-1550
- DOI
  10.3892/ijo.2013.1870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590248, KAKENHI-PROJECT-22591050, KAKENHI-PROJECT-25860398
[Journal Article]2013
- Author(s)
  Klionsky DJ, Abdalla FC, Abeliovich H, Miyazawa K, et al
- Journal Title
  
  Autophagy.
  
  Volume: 8 Pages: 445-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.2013
- Author(s)
  Karasawa S, Azuma M, Kasama T, Sakamoto S, Kabe Y, Imai T, Yamaguchi Y, Miyazawa K, Handa H
- Journal Title
  
  Mol Pharmacol
  
  Volume: 83 Issue: 3 Pages: 613-620
- DOI
  10.1124/mol.112.082602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050, KAKENHI-PROJECT-23570172, KAKENHI-PLANNED-23102002, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002
[Journal Article] Enhancement of cytotoxic and pro-apoptotic effects of 2-aminophenoxazine-3-one on the rathepatocellular carcinoma cell line dRLh-84, the human hepatocellular carcinoma cell line HepG2, and the rat normal hepatocellular cell line RLN-102012
- Author(s)
  Takemura A, Che XF, Tabuchi T, Moriya S, Miyazawa K, Tomoda A
- Journal Title
  
  Oncol Rep
  
  Volume: 27 Pages: 347-355
- DOI
  10.3892/or.2011.1531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells2012
- Author(s)
  Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, ItohM, Tomoda A
- Journal Title
  
  Int J Oncol.
  
  Volume: 40 Issue: 4 Pages: 1029-1039
- DOI
  10.3892/ijo.2011.1317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590248, KAKENHI-PROJECT-22591050
[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy.2012
- Author(s)
  Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT,　Miyazawa K, et al.
- Journal Title
  
  Autophagy.
  
  Volume: 8 Pages: 445-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmicreticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells.2012
- Author(s)
  Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A.
- Journal Title
  
  Int J Oncol.
  
  Volume: 40 Pages: 1029-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells.2012
- Author(s)
  Komatsu S, Miyazawa K(co-first author), Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A
- Journal Title
  
  Int J Oncol
  
  Volume: 40 Pages: 1029-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] オートファジーを考える　その基礎研究から臨床応用への展望2012
- Author(s)
  宮澤啓介
- Journal Title
  
  東京医科大学雑誌
  
  Volume: 70 Pages: 389-396
- NAID
  10031143018
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress2011
- Author(s)
  Kawaguchi T, Miyazawa K (co-first author), Moriya S, Ohtomo T, Che XF, Naito M, Itoh M, Tomoda A
- Journal Title
  
  Int J Oncol.
  
  Volume: 38 Issue: 3 Pages: 643-654
- DOI
  10.3892/ijo.2010.882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] D,L-Threo-1-phenyl-2-decanoyl- amino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.2011
- Author(s)
  Yamane M, Miyazawa K, Moriya S, Abe A, Yamane S
- Journal Title
  
  Biochimie
  
  Volume: 93 Pages: 1446-1459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Selectively induced apoptosis in human neutrophils in thepresence of oxidative phenoxazines, 2-amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one and 2-aminophenoxazine-3-one, preceded by decrease of intracellular pH, depolarization of the mitochond2011
- Author(s)
  Tabuchi T, Che XF, Hiraishi K, Adachi M, Miyano K, Sumimoto H, Tabuchi T, Miyazawa K, Tomoda A
- Journal Title
  
  JPharmacol Sci
  
  Volume: 117 Pages: 139-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K22011
- Author(s)
  Tsuchida A, Itoi T, Kasuya K, Nagakawa Y, Suzuki M, Ikeda T, Suzuki Y, Aoki T, Miyazawa K
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 58 Pages: 290-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Rapid decrease of intracellular pH associated with inhibition of Na^+/H^+ exchangerprecedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one.2011
- Author(s)
  Nagata H, Che XF, Miyazawa K, Tomoda A, Konishi M, Ubukata H, Tabuchi T
- Journal Title
  
  Oncol Rep
  
  Volume: 25 Pages: 341-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells.2011
- Author(s)
  Abe A, Yamada H, Moriya S, Miyazawa K
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 1264-1272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells2011
- Author(s)
  Moriya S, Miyazawa K (co-first author), Kawaguchi T, Che XF, Tomoda A
- Journal Title
  
  Int J Oncol.
  
  Volume: 39 Pages: 981-988
- DOI
  10.3892/ijo.2011.1072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K2 plus1alpha-hydroxyvitamin D3 combination therapy for low-risk myelodysplasticsyndromes.2010
- Author(s)
  Akiyama N, Miyazawa K, Kanda Y, Tohyama K, Omine M, Mitani K, Ohyashiki K
- Journal Title
  
  Leuk Res.
  
  Volume: 34 Pages: 1151-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Cytoprotective effect of imatinib mesylate in non-BCR-ABL-expressing cells along with autophagosome formation.2010
- Author(s)
  Ohtomo T, Miyazawa K, et al.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 391 Pages: 310-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Cytoprotective effect of imatinib mesylate in non-BCR-ABL-expressing cells along with autophagosome formation2010
- Author(s)
  Ohtomo T, Miyazawa K (co-first author), Naito M, Moriya S, Kuroda M, Itoh M, Tomoda A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 391 Pages: 310-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Multicenter phase II trial of vitamin K2 monotherapy and vitamin K2 plus 1 alpha-hydroxyvitamin D3 combination therapy for low-risk myelodysplastic syndromes.2010
- Author(s)
  Akiyama N, Miyazawa K, et al.
- Journal Title
  
  Leuk Res.
  
  Volume: 34 Pages: 1151-1157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] 2-Aminophenoxazine-3-oneinduces cellular apoptosis by causing rapid intracellular acidification andgenerating reactive oxygen species in human lung adenocarcinoma cells2010
- Author(s)
  Zheng CL, Che XF, Akiyama S, Miyazawa K, Tomoda A
- Journal Title
  
  Int JOncol.
  
  Volume: 36 Pages: 641-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Anticanceractivity of phenoxazines produced by bovine erythrocytes on colon cancer cells2010
- Author(s)
  Nakachi T, Tabuchi T, Takasaki A, Arai S, Miyazawa K, Tomoda A
- Journal Title
  
  Oncol Rep
  
  Volume: 23 Pages: 1517-1522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Phenoxazine derivatives suppress the infections caused by herpes simplex virus type-1 and herpes simplex virus type-2 intravaginally inoculated into mice2010
- Author(s)
  Hayashi K, Hayashi T, Miyazawa K, Tomoda A
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 85-91
- NAID
  10029889902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells.2010
- Author(s)
  Zheng CL, Che XF, Akiyama S, Miyazawa K, et al.
- Journal Title
  
  Int J Oncol.
  
  Volume: 36 Pages: 641-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Journal Article] Isolated erythrocythemia:a distinct entity ore a sub-type of polycythemia vera?2008
- Author(s)
  Ohyashiki K, Kiguchi T, Ito Y, Gotoh A, Tauchi T, Miyazawa K, et. al.
- Journal Title
  
  Jpn J Clin Oncol 38
  
  Pages: 230-232
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells2008
- Author(s)
  Yokoyama, T., Miyazawa, K., Naito, M., et. al.
- Journal Title
  
  Autophagy 4(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Isolated erythrocythemia:a distinct entity ore a sub-type of polycythemia vera?2008
- Author(s)
  Ohyashiki K, Kiguchi T, Ito Y, Gotoh A, Tauchi T, Miyazawa K, et. al.
- Journal Title
  
  Jpn J CIin Oncol 38
  
  Pages: 230-232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells2008
- Author(s)
  Yokoyama T, Miyazawa K, Naito M, et. al.
- Journal Title
  
  Autophagy 4
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features of adult acute leukemia with 11q23 abnormalities in Japan:a cooperative multicenter study2008
- Author(s)
  Tamai H, Yamaguchi H, Miyazawa K, et. al.
- Journal Title
  
  Int J Hematol. 87
  
  Pages: 195-202
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features of adult acute Ieukemia with 11q23 abnormalities in Japan:a cooperative multicenter study2008
- Author(s)
  Tamai H, Yamaguchi H, Miyazawa K, et. al.
- Journal Title
  
  Int J Heinatol. 87
  
  Pages: 195-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells2008
- Author(s)
  Yokoyama T, Miyazawa K, Naito M, et. al.
- Journal Title
  
  Autophagy 4(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Diagnostic contribution of sputum cytology in a case of non-Hodgkin lymphoma2007
- Author(s)
  Toyotake J, Miyazawa K, Katagiri T, Yamaguchi N, Serizawa H, Ohyashiki K
- Journal Title
  
  Intern Med 46
  
  Pages: 63-64
- NAID
  130000076762
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features of hypereosinophilic syndrome : FIPILI-PDGFRA fusion gene-positive disease is a distinct clinical entity with myeloproliferative features and a poor response to corticosteroid.2007
- Author(s)
  Miyazawa K, Kakazu N, Ohyashiki K
- Journal Title
  
  Int J Hematol. 85・1
  
  Pages: 5-10
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Uncontrolled thrombocytosis in polycythemia vera is a risk for thrombosis,regardless of JAK2(V617F)mutation status2007
- Author(s)
  Ohyashiki K, Akahane D, Gotoh A, Ito Y, Tauchi T, Miyazawa K, et. al.
- Journal Title
  
  Leukemia 21
  
  Pages: 2544-2555
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Translocation(10;21)(q21;q22)in myelodysplastic syndrome.2007
- Author(s)
  Rashaan Z, Ito Y, Takaku T, Toyotake J, Miyazawa K, et al.
- Journal Title
  
  Cancer Genet Cytogenet. 173・1
  
  Pages: 81-82
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features of adult leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study2007
- Author(s)
  Tamai, H., Yamaguchi, H., Hamaguchi, H., Miyazawa, K., et. al.
- Journal Title
  
  Int J Hematol 87
  
  Pages: 195-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features if hypereosinophilic syndrome:FIP1L1-PGFA fusion gene-positive disease is a distinct clinical entity with myeloproliferative features and a poor response to corticosteroid2007
- Author(s)
  Miyazawa K, Kakazu N, Ohyashiki K
- Journal Title
  
  Int J Hematol 85
  
  Pages: 5-10
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Diagnostic contribution of sputum cytology in a case of non-Hodekin lymphoma. I2007
- Author(s)
  Toyotake J, Miyazawa K, et al.
- Journal Title
  
  Intern Med. 46・1
  
  Pages: 63-64
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines2007
- Author(s)
  Enomoto M, Tsuchiba A, Miyazawa K, et. al.
- Journal Title
  
  Int J Mol Med. 20
  
  Pages: 801-809
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Translocation (10;21)(q21;q22)in myelodysplastic syndrome2007
- Author(s)
  Rashaan Z, Ito Y, Takaku T, Toyatame J, Miyazawa K, Kodama A, Ohyashiki K
- Journal Title
  
  Cancer Genet Cytogenet 173
  
  Pages: 81-82
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Clinical features of hypereosinophilic syndrome : FIP1L1-PDGFRA fusion gene-positive disease is a distinct clinical entity with myeloproliferative features and a poor response to corticosteroid2007
- Author(s)
  Miyazawa, K., Kakazu, N., Ohyashiki, K
- Journal Title
  
  Int J Hematol 85
  
  Pages: 5-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Deletion (20q) as the sole abnormality in Waldenstrom macroglobulinemia suggests distinct pathogenesis of 20q11 anomaly.2006
- Author(s)
  Liu YC, Miyazawa K, et al.
- Journal Title
  
  Cancer Genet Cytogenet. 169・1
  
  Pages: 69-72
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cell lines2006
- Author(s)
  Tokita H, Tsuchida A, Miyazawa K, Ohyashiki K, Katayanagi S, Sudo H, Enomoto M, Takagi Y, Aoki T
- Journal Title
  
  Int J Mol Med 17
  
  Pages: 235-243
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Derivative (1;7)(q10;p10)in multiple myeloma.A sign of therapy-related hidden myelodysplastic syndrome2006
- Author(s)
  Ishii Y, Hsia HH, Sashida G, Ito Y, Miyazawa K, Kodama A, Ohyashiki JH, Ohyashiki K
- Journal Title
  
  Cancer Genet Cytogenet 167
  
  Pages: 131-137
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cel lines.2006
- Author(s)
  Tokita H, Tsuchida A, Miyazawa K,. et al.
- Journal Title
  
  Int J Mol Med. 17・2
  
  Pages: 235-243
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Deletion(20q)as the sole abnormality in Waldenstrom macroglobulinemia suggests distinct pathogenesis of 20q11anomaly2006
- Author(s)
  Liu YC, Miyazawa K, Sashida G, Komada A, Ohyashiki K
- Journal Title
  
  Cancer Genet Cytogenet 169
  
  Pages: 69-72
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591089
[Journal Article] Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells
- Author(s)
  Komatsu S, Moriya S, Che X-F, Yokoyama T, Kohno N, Miyazawa K
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] ERストレスはruxolitinibの変異CALR導入細胞増殖抑制効果を増強する2020
- Author(s)
  森山充, 赤羽大悟, 森谷昇太, 山田ありさ, 今井美沙, 荒木真理人, 小松則夫, 宮澤啓介, 後藤明彦:
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06690
[Presentation] CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化による空胞形成を伴った新規細胞死を誘導する2020
- Author(s)
  日野　浩嗣, 入山　規良，國場　寛子，風間　宏美，森谷昇太，高野　直治，平本　正樹，相澤　　信，宮澤　啓介
- Organizer
  第125回日本解剖学会総会全国学術集会・2020年3月25日・山口
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 乳がん細胞におけるミトコンドリアダメージにより誘導されるBRCA1の新規分解機構の解析2019
- Author(s)
  高野　直治，宮原　か奈，山田　裕美子，風間　宏美，徳久　真弓，日野　浩嗣，藤田　浩司，Barroga Edward，平本　正樹，半田　宏，黒田　雅彦，石川　孝，宮澤　啓介
- Organizer
  第184回　東京医科大学医学会総会・2019年11月16日・東京
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] CDK4/6阻害薬abemaciclibによるリソソーム由来の空胞形成を伴った新規細胞死誘導2019
- Author(s)
  日野浩嗣, 入山　規良，國場　寛子，風間　宏美，森谷　昇太，高野　直治，平本　正樹，宮澤　啓介
- Organizer
  第92回　日本生化学会大会・2019年9月18日・横浜
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Comparison of autophagy inducing effect in various tyrosine kinase inhibitors in cancer cells by quantitative autophagy flux monitoring system2019
- Author(s)
  田中　英基, 日野　浩嗣，森谷　昇太，風間　宏美，高野　直治，阿部　晃久，平本　正樹，宮澤　啓介，塚原　清彰
- Organizer
  第183回　東京医科大学医学会総会・2019年6月1日・東京
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 乳がん細胞におけるミトコンドリアダメージによって誘導されるBRCA1の新規分解機構2019
- Author(s)
  高野　直治, 宮原　か奈，山田裕美子，風間　宏美，徳久　真弓，日野　浩嗣，藤田　浩司，Barroga E, 平本　正樹，半田　宏，黒田　雅彦，石川　　孝，宮澤　啓介
- Organizer
  第92回　日本生化学会大会・2019年9月18日・横浜
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Actin cytoskeleton reorganization mediated by a cellular target of gefitinib2019
- Author(s)
  Hiramoto M, Takano N, Kazama H, Hino H, Miyazawa K
- Organizer
  第78回　日本癌学会・2019年9月26日・京都
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Lysosome-targeted atypical cell-death with vacuolar formation by CD4/6 inhibitor abemaciclib2019
- Author(s)
  Hino H., Kazama H, Moriya S, Takano N, Hiramoto M, Miyazawa K
- Organizer
  第78回　日本癌学会・2019年9月26日・京都
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Mitochondrial damage induces BRCA1 degradation in breast cancer cells2019
- Author(s)
  Takano N, Miyahara K, Kazama H, Hino H, Hiramoto M, Kuroda M, Ishikawa T, Miyazawa K
- Organizer
  第78回　日本癌学会・2019年9月26日・京都
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Combined treatment with bortezomib plus clarithrowycin overcomes stromal cell-mediated drug resistance in myeloma cells via ER-stress and NOXA induction2019
- Author(s)
  森谷　昇太、風間　宏美，高野　直治，平本　正樹，宮澤　啓介
- Organizer
  第184回　東京医科大学医学会総会・2019年11月16日・東京
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 抗寄生虫薬の抗がん剤としてのリポジショニングの可能性について2019
- Author(s)
  小川雅人，鈴木菫，宮﨑　誠也，風間　宏美，平本　正樹，宮澤　啓介
- Organizer
  第184回　東京医科大学医学会総会・2019年11月16日・東京
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Lysosome-targeted cytocidal effect of CDK4/6 inhibitor abemaciclib2018
- Author(s)
  Hirotsugu Hino, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa
- Organizer
  第77回　日本癌学会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Identification of intracellular target of azithromycin as an autophagy inhibitor2018
- Author(s)
  Takano N, Hiramoto M, Miyazawa K.
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] チロシンキナーゼ阻害薬ゲフィチニブによるオートファジー調節作用に関わる分子標的探索2018
- Author(s)
  平本正樹、日野浩嗣、徳久真弓、風間宏美、高野直治、宮澤啓介
- Organizer
  第91回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] HER2陽性乳癌細胞株における多機能アダプタータンパク質p62/SQSTM1の解析2018
- Author(s)
  横田歩香、平本正樹、日野浩嗣、徳久真弓、風間宏美、高野直治、宮澤啓介
- Organizer
  第182回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] CDK4/6阻害薬アベマシクリブはリソソーム機能阻害に起因する空胞形成を伴った細胞死を誘導する2018
- Author(s)
  日野浩嗣、國場寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第182回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] チロシンキナーゼ阻害薬の分子標的によるオートファジー調節作用2018
- Author(s)
  平本正樹、日野浩嗣、徳久真弓、風間宏美、高野直治、宮澤啓介
- Organizer
  第182回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 再発乳癌に対する「小胞体ストレス負荷療法」の確立を目的としたMDA-MB-231-ERAI-venusシステムの応用2018
- Author(s)
  宮原か奈、風間宏美、宮澤啓介、石川孝
- Organizer
  第26回　日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] プロトンポンプ阻害薬とマクロライド系抗生剤との併用による殺細胞効果の増強2018
- Author(s)
  武田淳雄、高野直治、森谷昇太、風間宏美、日野浩嗣、山田裕美子、阿部晃久、平本正樹、宮澤啓介、塚原清彰
- Organizer
  第182回　東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] CDK4/6阻害薬abemaciclibはリソソーム由来の空胞形成を伴った細胞死を誘導する2018
- Author(s)
  日野浩嗣、入山規良、國場　寛子、風間宏美、森谷昇太、高野直治、平本正樹、宮澤啓介
- Organizer
  第91回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] アミノ酸飢餓条件下におけるEGFR発現癌細胞に対するゲフィチニブのネクロプトーシス様細胞死を介した殺細胞増強効果.2017
- Author(s)
  齊藤雄, 森谷昇太, 風間宏美, 平澤一浩, 宮原か奈, 高野直治, 平本正樹, 塚原清彰, 宮澤啓介
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Macrolides enhance bortezomib induced cytotoxicity and overcome stromal cell mediated drug resistance in myeloma cells.2017
- Author(s)
  森谷昇太，風間宏美，平本正樹，宮澤啓介，半田　宏
- Organizer
  東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 多発性硬化症治療薬FTY720の抗腫瘍効果の検討2017
- Author(s)
  太田　行紀、大熊　尭、平本正樹、日野浩嗣、風間宏美、森谷昇太、高野直治、宮澤啓介
- Organizer
  東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] CDK4/6阻害薬abemaciclibはmethuosis様の細胞死を誘導する.2017
- Author(s)
  日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 宮澤啓介.
- Organizer
  2017年度生命科学系学会合同年次大会第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] マクロライド抗生剤は骨髄細胞株のストローマ細胞接着依存性プロテアソーム阻害剤耐性を克服し、殺細胞作用を増強する.2017
- Author(s)
  森谷昇太, 風間宏美, 平本正樹, 宮澤啓介
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] 乳癌細胞における小胞体ストレス負荷誘導療法の確立に向けたERAI-venusシステムを用いた効率的な薬剤併用投与法の検討2017
- Author(s)
  風間宏美, 平本正樹, 宮原か奈, 高野直治, 宮澤啓介
- Organizer
  第76回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08771
[Presentation] Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition2016
- Author(s)
  Kazuhiro Hirasawa、Shota Moriya、Kana Miyahara、Hiromi Kazama、Ayako Hirota、Jun Yoshida、Akihisa Abe、Masato Inazu、Masaki Hiramoto、Kiyoaki Tsukahara、Keisuke Miyazawa
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K21387
[Presentation] ビノレルビンは乳癌細胞株においてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016
- Author(s)
  宮原か奈, 森谷昇太, 小松誠一郎, 平澤一浩, 阿部晃久, 平本正樹, 石川孝, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer.2016
- Author(s)
  森谷昇太、風間宏美、　平本正樹、　相澤信、砂塚敏明、半田　宏、宮澤啓介
- Organizer
  第78回　日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016
- Author(s)
  Morishita S, Kzazma H, Hiramoto M, Aizawa S, Sunazuka T, Handa H, Miyazawa K
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] アミノ酸飢餓状態下で、マクロライド系抗菌薬はオートファジー阻害により頭頸部癌細胞株の細胞死を誘導する2016
- Author(s)
  平澤一浩、宮原か奈、塚原清彰、森谷昇太、平本正樹、宮澤啓介
- Organizer
  第75回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] Vinorelbine enhances bortezomib-induced cytotoxic effect via blocking aggresome formation in breast cancer cell lines.2016
- Author(s)
  Miyahara K, Moriya S, Komatsu S, Hirasawa K, Abe A, Hiramoto M, Ishikawa T, Miyazawa K
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26670589
[Presentation] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER-stress loading in breast cancer cell lines2016
- Author(s)
  宮原か奈、小松誠一郎、風間宏美、森谷昇太、廣田綾子、武村淳、阿部晃久、平本正樹、平澤一浩、國場寛子、石川孝、宮澤啓介
- Organizer
  第177回東京医科大学医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26670589
[Presentation] マクロライドとオートファジー2016
- Author(s)
  宮澤啓介
- Organizer
  第23回マクロライド新作用研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] アミノ酸飢餓状態下で、マクロライド系抗菌薬はオートファジー阻害により頭頸部癌細胞株の細胞死を誘導する2016
- Author(s)
  平澤一浩, 森谷昇太, 宮原か奈, 平本正樹, 塚原清彰, 宮澤啓介
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016
- Author(s)
  Moriya S, Miyazawa K et al.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] ビノレルビンは乳癌細胞株に於いてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016
- Author(s)
  宮原か奈、森谷昇太、平澤一浩、平本正樹、小松誠一郎、石川　孝、阿部晃久、宮澤啓介
- Organizer
  第75回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] ビタミンＫ２の抗腫瘍効果とその臨床応用の可能性2015
- Author(s)
  宮澤啓介
- Organizer
  第25回日本産婦人科学会・新生児血液学会学術集会・第18回ビタミンＫフォーラム
- Place of Presentation
  東京ＪＡ共済ビル
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] Trangeting autophagy with clarithromycin enhances gefitinib-induced cell death in non-small cell lung cancer cells2015
- Author(s)
  森谷昇太、車暁芳、横山智央、平本正樹、宮澤啓介
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K07972
[Presentation] 造血器腫瘍に対する細胞内タンパク質分解ネットワーク機構を標的とする新規治療法2014
- Author(s)
  宮澤啓介
- Organizer
  高齢者造血器疾患研究会
- Place of Presentation
  東京都　新宿
- Year and Date
  2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] Simultaneously targeting autophagy with macrolide and proteasome with bortezomib in myeloma cells.2012
- Author(s)
  Moriya S, Che XF, Komatsu S, Tomoda A, Miyazawa K.
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] 2-aminophenoxazine-3-one (Phx-3) induces apoptosis via a ROS/JNK-dependent pathway in human glioblastoma cell line LN2292012
- Author(s)
  Che XF, Miyazawa K, Moriya S, Zheng C, Abe A, Tomoda A
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] オートファジーを考えるその基礎研究から臨床応用への展望2012
- Author(s)
  宮澤啓介
- Organizer
  第169回東京医科大学医学会総会
- Place of Presentation
  東京
- Year and Date
  2012-06-02
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Combined treatment with clarithromycin and bortezomib enhances cytotoxicity via endplasmic reticulum stress-meidated CHOP induction and autophagy in breast cancer cells2012
- Author(s)
  Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Combined treatment with bortezomib plus macrolide antibiotics enhances ER-stress mediated cytotoxicity in myeloma cells.2012
- Author(s)
  Moriya S, Che XF, Komatsu S, Tomoda A, Miyazawa K.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Combined treatment with bortezomib plus macrolide antibiotics enhances ER-stress mediated cytotoxicity in myeloma cells2012
- Author(s)
  Moriya S, Che XF, Komatsu S, Tomoda A, Miyazawa K
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Combined treatment with clarithromycin and bortezomib enhances cytotoxicity via endplasmic reticulum stress-meidated CHOP induction and autophagy in breast cancer cells.2012
- Author(s)
  Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A.
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Targeting autophagy with clarithromycin and proteasome with bortezomib enhances ER-stress in breast cancer cells.2012
- Author(s)
  Komatsu S, Moriya S, Kohno N, Tomoda A, Miyazawa K
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Simultaneously targeting autophagy with macrolide and proteasome with bortezomib in myeloma cells2012
- Author(s)
  Che XF, Komatsu S, Tomoda A, Miyazawa K
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Anti-EGFR antibody conjugated gold liposome for molecular imaging and therapy on NSCLC cells2011
- Author(s)
  横山智央, 宮澤啓介, 野村将春, 後藤典子 , 大屋敷一馬
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] ER stress-mediated cell death by bortezomib and autophagy inhibition in myeloma cells2011
- Author(s)
  Miyazawa K, Kawaguchi T, Moriya S, Che X-F, Tomoda A
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Endoplasmic reticulum stress-mediated CHOP (GADD153) induction is involved in the cytotoxicity of 2-amino-phenoxazine-3-one in cancer cells.2011
- Author(s)
  森谷昇太, 宮澤啓介,川口寛裕,車暁芳,友田〓夫
- Organizer
  第34回日本分子生物学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Cytoprotective autophagy induction by imatinib mesylate in non-BCR-ABL expressing cells2010
- Author(s)
  Miyazawa K, et al.
- Organizer
  第52回アメリカ血液学会総会
- Place of Presentation
  米国,フロリダ州,オーランド
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] Combined treatment with bortezomib plus bafilomycin A1 enhances cytocidal effect along with induction of ER-stress in myeloma cells2010
- Author(s)
  Miyazawa K, Moriya S, Kawaguchi T, Ohtomo T, Che XF, Maito M, Itoh M, Tomoda A
- Organizer
  第52回アメリカ血液学会総会
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation]2010
- Author(s)
  森谷昇太,宮澤啓介,川口寛裕,大友理,車暁芳,内藤宗和,伊藤正裕,友田〓夫
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22591050
[Presentation] ビタミンK2による白血病細胞のオートファジー/アポトーシス誘導2007
- Author(s)
  宮澤啓介、横山智央、豊武寿理、井口具隆、後藤明彦、湯尾明、大屋敷一馬
- Organizer
  第69回日本血液学会総会/第49回日本臨床血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells and Bcl-2 expression level determines the phenotype of their cell death2007
- Author(s)
  Miyazawa K, et. al.
- Organizer
  アメリカ血液学会総会
- Place of Presentation
  米国アトランタ
- Year and Date
  2007-12-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] Simultaneous induction of autophagy and apoptosis in leukemic cells by vitamin K22007
- Author(s)
  Miyazawa K, et. al.
- Organizer
  Keystone Symposium:Apoptosis and non-apoptotic pathway.
- Place of Presentation
  米国カリフォルニア
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] VitaminK2は胆管癌細胞株TFK-1に対してautophagyを伴った抗腫瘍効果を有する2007
- Author(s)
  榎本正統, 土田明彦, 宮澤啓介, 横山智央, 鴇田博美, 内藤宗和, 伊藤正裕, 大屋敷一馬, 青木達哉
- Organizer
  日本癌治療学会
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] Simultaneous induction of autophagy and apoptosis in leukemic cells by vitamin K22007
- Author(s)
  Keisuke, Miyazawa, Tomohisa, Yokoyama, Juri, Toyotake, Akihiko, Gotoh, Munekazu, Naito, Masahiro, Ito, Akira, Yuo, Seiji, Kondo, Kazuma, Oyhashiki
- Organizer
  Keystone Symposium : Apopotis and non-apoptotic pathway
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells and Bc1-2 expression level determines the phenotype of their cell death2007
- Author(s)
  Keisuke, Miyazawa, Tomohisa, Yokoyama, Munekazu, Naito, Jun, Toyotake, Testuzo, Tauchi, Masahiro, Itoh, Akira, Yuo, Yasuko, Kondo, Seiji, Kondo, Kazuma, Ohyashiki
- Organizer
  The 48th Annual Meeting of American Society of Hematology
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] VitaminK2は胆管癌細胞株TFK-1に対してautophagyを伴った抗腫瘍効果を有する。2007
- Author(s)
  榎本正統、土田明彦、宮澤啓介、横山智央、鴇田博美、内藤宗和、伊藤正裕、大屋敷一馬、青木達哉
- Organizer
  日本癌治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] ビタミンK2による白血病細胞のオートファジー/アポトーシス誘導2007
- Author(s)
  宮澤啓介, 横山智央, 豊武寿理, 井口具隆, 後藤明彦, 湯尾明, 大屋敷一馬
- Organizer
  第69回日本血液学会総会/第49回日本臨床血液学会総会(合同総会)
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] Vitamin K2 induces autophagy and apoptosis simultaneously in leukemi a cells and Bcl-2 expression level determines the phenotype of their cell death2007
- Author(s)
  Miyazawa K, et. al.
- Organizer
  アメリカ血液学会総会
- Place of Presentation
  米国アトランタ
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] 白血病細胞における低用量シタラビン(Ara-C)によるオートファジー誘導とAra-C+G-CSF併用による殺細胞増強効果2007
- Author(s)
  豊武寿理, 宮澤啓介, 大屋敷一馬, 内藤宗和, 伊藤正裕
- Organizer
  東京医科大総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] 骨髄異形成症候群の分子病態と新しい治療法不応性貧血に対するビタミンK2(VK2)単一療法とVK2+D3併用療法(Vitamin K2(VK2) Monotherapy and VK2 plus D3 Combination Therapy in Refractory Anemia)2006
- Author(s)
  宮澤啓介
- Organizer
  第68回日本血液学会総会/第48回日本臨床血液学会総会(合同総会)
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] 慢性骨髄増殖性疾患におけるJAK2-V617F変異の臨床血液所見の特徴2006
- Author(s)
  木口亨, 大屋敷一馬, 後藤明彦, 赤羽大悟, 田内哲三, 伊藤良和, 荘司奈穂子, 岡部聖一, 井口具隆, 高久智生, 山田聖子, 布田晃介, 豊武寿理, 藤本博昭, 宮澤啓介, 木村之彦, 大屋敷純子
- Organizer
  第68回日本血液学会総会/第48回日本臨床血液学会総会(合同総会)
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] BCL-2発現量依存性のビタミンK2(VK2)による白血病細胞のオートファジー/アポトーシス誘導の制御2006
- Author(s)
  横山智央, 宮澤啓介, 豊武寿理, 後藤明彦, 大屋敷一馬, 内藤宗和, 小茂田文子, 伊藤正裕, 湯尾明, 近藤精二
- Organizer
  第65回日本癌学会総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591089
[Presentation] タンパク質分解系およびアグリソームを標的とした骨髄腫細胞株の殺細胞効果の増強
- Author(s)
  森谷昇太，平本正樹，宮澤啓介，他
- Organizer
  日本血液学会第76回学術集会
- Place of Presentation
  大阪府　大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26460478
[Presentation] Simultaneous targeting aggresome, proteasome, and autophagy potentiates ER-stress mediated cell death in myeloma cells
- Author(s)
  森谷昇太，平本正樹，宮澤啓介，他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県　横浜市　パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26460478

1. YAGUCHI Makoto (50246310)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. GOTOH Akihiko (00297293)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. YOKOYAMA Tomohisa (40408240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 平本正樹 (70297828)

# of Collaborated Projects: 2 results

# of Collaborated Products: 38 results
5. 小松則夫 (50186798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ITOI Takao (60338796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HANDA Hiroshi (80107432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. Umahara Takahiko (70266477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Komatsu Seiichiro (40408208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. HISASUE Masaharu (80333144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. IKEBUCHI Keinji (20175194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IGUCHI Tomotaka (60408078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. Hirasawa Kazuhiro (90772161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. MORIYA Shota (30634935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 外山圭助 (00051293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大屋敷純子 (20191950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 大屋敷一馬 (20201387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 秋元治朗 (10212440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 羽生春夫 (10228520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 清水聰一郎 (10385031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 橋本孝朗 (60266517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 赫寛雄 (70307338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 織田順 (60459500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 矢口誠 (90276949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAKAMURA Takuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ARAKI Marito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 稲津正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 舟橋伸昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 日野浩嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyazawa Keisuke 宮澤 啓介

MIYAZAWA Keisuke 宮澤 啓介

宮沢 啓介 ミヤザワ ケイスケ

宮澤 啓介 ミヤザワ ケイスケ

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A novel therapeutic method for multiple myeloma by comprehensive control of intracellular protein degradation mechanismPrincipal Investigator

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ER-stress loading therapy in refractory multiple myelomaPrincipal Investigator

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Targeting tyrosine kinases for autophagy induction along with cytoprotective effect in hematopoietic progenitor cellsPrincipal Investigator

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Regulatory mechanism between autophagy and apoptosis in leukemia cellsPrincipal Investigator

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Establishment of Vitamin K2 Therapy in Myelodysplastic SyndromesPrincipal Investigator

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Effects of Vitamin K2 in Patients with Myelodysplastic Syndromes-From The Standing Point of Apoptosis Inducing Effects of Vitamin K2 on Leukemia Cells-Principal Investigator

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Hematopoietic Cell Maturation Is Regulated by Maintaining a Balance against Cytokine Induced-Cell Proliferation - Clinical Application for Differentiation-inducing Therapy of Leukemia-Principal Investigator

Principal Investigator

Miyazawa Keisuke 宮澤啓介

MIYAZAWA Keisuke 宮澤啓介

宮沢啓介ミヤザワケイスケ

宮澤啓介ミヤザワケイスケ

[Book] DNAメチル化阻害剤みんなに役立つ骨髄異形成症候群の基礎と臨床2008