ADACHI Takahiro 安達貴弘

Researcher Number	50222625
Other IDs
Affiliation (Current)	2019: 東京医科歯科大学, 難治疾患研究所, 准教授
Affiliation (based on the past Project Information) *help	2007 – 2019: Tokyo Medical and Dental University, 難治疾患研究所, 准教授 2000 – 2006: 東京医科歯科大学, 難治疾患研究所, 助教授 1997 – 1999: 東京医科歯科大学, 難治疾患研究所, 講師 1997: 名古屋大学, 農学研究科, 助手 1996: 名古屋大学, 農学部, 助手 1991 – 1993: 名古屋大学, 農学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / 食品科学・栄養科学 / Immunology / 細胞死(アポトーシス) Except Principal Investigator 製造化学・食品 / Immunology / Immunology / Food science / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator シグナル伝達 / B細胞 / カルシウムシグナル / 抗原受容体 / 生体イメージング / イネ / Bリンパ球 / 記憶B細胞 / CD22 / IgE … More Except Principal Investigator BCR / コメアレルゲン蛋白質 / トランスジェニックイネ / Rice Allergenic Protein / Bリンパ球 / p27 / 抗原受容体 / c-Myc / Lyn / B lymphocyte / BCR signaling / Syk / adaptor molecule / BLNK / PLC-γ2 / CD22 / CD72 / ITIM / IgG / IgE / アンチセンスRNA法 / イネゲノム遺伝子 / 米アレルゲン蛋白質 / 遺伝子 / シスエレメント / 転写調節領域 / ゲノムDNA / Anti-Sense RNA / Allergenic Protein Promoter / Transgenic Plant / Rice Seeds / Genetic Engineering Study / 食餌性アレルギー / アンチセンス遺伝子 / アレルゲン蛋白質 / 低アレルゲン米 / 転写調節因子 / アンチセンスRNA / Food Allergy / Antisense RNA / Transgenic Rice Plants / 細胞死 / CDKインヒビター / 細胞周期 / CDK / 誘導的発現 / 増殖 / p21 / Cdkインヒビター / cell death / CDK inhibitor / antigen receptor / cell cycle / Btk / JNK / BCRシグナル / PLC-_γ2活性化 / ERK活性化 / JNK活性化 / p38活性化 / Vav / チロシン燐酸化 / NF-AT活性化 / シグナル伝達 / IgA / レクチン / 免疫グロブリン / アイソタイプ / 抗体産生 / signal transduction / 短寿命活性種 / 自然免疫 / ポリスルフィド / タンパク質フォールディング / 食品機能性 / 渋味 / 脳腸相関 Less

Neurophysical approach in beneficial physiological changes induced by the specific taste through the axes of digestive tract, brain and peripheral tissuesOngoing
- Principal Investigator
  
  越阪部奈緒美
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shibaura Institute of Technology
Life science basis of short-lived reactive species originated from foodsOngoing
- Principal Investigator
  
  内田浩二
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Food science
- Research Institution
  The University of Tokyo
Visualizatiion of immune responses by 5D intravital imagingPrincipal Investigator
- Principal Investigator
  
  ADACHI Takahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
免疫担当細胞の活性化の可視化とそれを用いた免疫反応の解析Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
maintenance and activation mechanisms of memory B cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI Takahiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Analysis of the robust antibody-production of memory B cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI Takahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Analysis of activation, maintenance and antibody production of IgE positive B cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI Takahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
細胞周期停止によるアポトーシスにおける蛋白質分解系の機能Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
共受容体による免疫グロブリンクラス特異的なB細胞活性化制御Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
メモリーB細胞活性化制御の分子機構解明Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Roles of membrane-bound lectins in the regulation of immune cells.
- Principal Investigator
  
  TSUBATA Takeshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Molecular mechanism of cell cycle arrest-induced apoptosisPrincipal Investigator
- Principal Investigator
  
  ADACHI Takahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Tokyo Medical and Dental University
膜蛋白質CD72によるB細胞活性化制御機構の解析Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
イネ種子中での高効率な人為的遺伝子制御系の確立とコメ成分改良への応用Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Tokyo Medical and Dental University
Study of CDK inhibitors in B cell immune response
- Principal Investigator
  
  TSUBATA Takeshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Medical Research Intitute, Tokyo Medical and Dental University
Functional analysis of Syk substrates in B cell receptor signaling
- Principal Investigator
  
  KUROSAKI Tomohiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kansai Medical University
広範囲の患者に有効な低アレルゲン化米の開発Principal Investigator
- Principal Investigator
  
  安達貴弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Nagoya University
Production of Hypoallergenic Rice by Gene Engineering
- Principal Investigator
  
  NAKAMURA Ryo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  製造化学・食品
- Research Institution
  Nagoya University
Studies on the Suppression of Allergenic Proteins in Rice Seeds by Genetic Engineering
- Principal Investigator
  
  NAKAMURA Ryo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  製造化学・食品
- Research Institution
  Nagoya University

[Book] 炎症と免疫2016
- Author(s)
  安達貴弘
- Total Pages
  7
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K08526
[Book] 臨床免疫・アレルギー科2011
- Author(s)
  安達貴弘
- Total Pages
  213
- Publisher
  CD70と自己免疫疾患
- Data Source
  KAKENHI-PROJECT-21590529
[Book] 臨床免疫・アレルギー科2011
- Author(s)
  安達貴弘
- Total Pages
  452
- Publisher
  メモリーB細胞におけるBCRシグナル伝達
- Data Source
  KAKENHI-PROJECT-21590529
[Journal Article] B cell activation in the cecal patches during the development of an experimental colitis model2018
- Author(s)
  Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
- Journal Title
  
  Biochem Biophys res Commun.
  
  Volume: 496 Pages: 367-373
- DOI
  10.1016/j.bbrc.2018.01.053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-15H05786, KAKENHI-PROJECT-16H05286, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-15K08526, KAKENHI-PROJECT-26221307, KAKENHI-PROJECT-18K07997, KAKENHI-PROJECT-17K19513, KAKENHI-PROJECT-17K19674
[Journal Article] 生体イメージングによる食シグナルおよび超早期未病の可視化解析2018
- Author(s)
  安達貴弘
- Journal Title
  
  化学と生物
  
  Volume: 56 Pages: 345-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08526
[Journal Article] Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset2016
- Author(s)
  Yoshikawa S, Usami T, Kikuta J, Ishii M, Sasano T, Sugiyama K, Furukawa T, Nakasho E, Takayanagi H, Tedder TF, Karasuyama H, Miyawaki A, Adachi T.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 18738-18738
- DOI
  10.1038/srep18738
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08526, KAKENHI-PROJECT-15K15049, KAKENHI-PUBLICLY-15H01158, KAKENHI-PROJECT-15H05671, KAKENHI-PROJECT-24590575, KAKENHI-PROJECT-25461045, KAKENHI-PROJECT-26293052
[Journal Article] Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo.2016
- Author(s)
  *Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, Hazato N, Miyawaki A, Yoshikawa S, Usami T, Karasuyama H, Kimoto-Nira H, *Hirayama K, *Tsuji NM.
- Journal Title
  
  Front Immunol.
  
  Volume: 7 Pages: 601-601
- DOI
  10.3389/fimmu.2016.00601
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04504, KAKENHI-PROJECT-15K08526
[Journal Article] A system for reconstructing B cell antigen receptor signaling in the mouse myeloma J558L cell line.2013
- Author(s)
  Harumiya S, Yoshino A, Hayashizaki K, Mizuno K, Yakura H, Adachi T.
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 533 Pages: 18-24
- DOI
  10.1016/j.abb.2013.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590575
[Journal Article] CD22 serves as a receptor for soluble IgM.2012
- Author(s)
  Adachi T, Harumiya S, Takematsu H, Kozutsumi Y, Wabl M, Fujimoto M, Tedder TF
- Journal Title
  
  Eur J Immunol
  
  Volume: 42 Pages: 241-7
- Data Source
  KAKENHI-PROJECT-21590529
[Journal Article] CD22 serves as a receptor for soluble IgM2012
- Author(s)
  T.Adachi, et al.
- Journal Title
  
  Eur.J.Immunol.
  
  Volume: 42 Pages: 241-247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590529
[Journal Article] Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic resticulum.2012
- Author(s)
  Hitomi Y, et al.
- Journal Title
  
  BMC Immunol.
  
  Volume: 13 Pages: 72-72
- DOI
  10.1186/1471-2172-13-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390199, KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-23591459, KAKENHI-PROJECT-24590575
[Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells2009
- Author(s)
  Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T., Nakada, H.
- Journal Title
  
  Biochem J. 417
  
  Pages: 673-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice2009
- Author(s)
  Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
- Journal Title
  
  Biochem Biophys Res Commun. 380
  
  Pages: 193-197
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72b congenic mice2009
- Author(s)
  Hou, R., Ohtsuji, M., Ohtsuji, N., Zhang, L., Adachi, T., Hirose, S., Tsubata, T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 380 Pages: 193-7
- Data Source
  KAKENHI-PROJECT-21590529
[Journal Article] Ligation of tumor-produced mucins to CD22 dramatically impairs splenic marginal zone B cells2009
- Author(s)
  Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adachi, T., Tsubata, T. and Nakada, H.
- Journal Title
  
  Biochem J
  
  Volume: 417 Pages: 673-83
- Data Source
  KAKENHI-PROJECT-21590529
[Journal Article] Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen2008
- Author(s)
  Zhu, C., Sato, M., Yanagisawa, T., Fujimoto, M., Adachi, T., Tsubata, T.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 1653-1659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] ER stress is involved in B cell antigen receptor ligation-induced apoptosis2008
- Author(s)
  Yan, B-C., Adachi, T., Tsubata, T.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 143-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Design, synthesis, and structure-affinity relationships of novel series of Sialosides as CD22-Specific Inhibitors2008
- Author(s)
  Abdu-Allah, H. H., Tamanaka, T., Yu, J., Zhuoyuan, L., Sadagopan, M., Adachi, T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
- Journal Title
  
  J Med Chem. 51
  
  Pages: 6665-6668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] FRET-based Ca^<2+> measurement in B lymphocyte by flow cytometry and confocal microscopy2008
- Author(s)
  Adachi, T, Tsubata, T.
- Journal Title
  
  Biochem Biophys Res Commun 367
  
  Pages: 377-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] FRET-based Ca2+ measurement in B lymphocyte by flow cytometry and confocal microscopy2008
- Author(s)
  Adachi, T.
- Journal Title
  
  Biochem Biophys Res Commun 367
  
  Pages: 377-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts2007
- Author(s)
  Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Ya., Ishida, H., Kiso, M., Tsubata, T.
- Journal Title
  
  Biochem Biophys Res Commun 360
  
  Pages: 759-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Interdomain A is crucial for ITAM-dependent and-independent regulation of Syk2007
- Author(s)
  Adachi, T., Wienands, J.,Tsubata, T., Kurosaki, T.
- Journal Title
  
  Biochem Biophys Res Commun 364
  
  Pages: 111-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] Interdomain A is crucial for ITAM-dependent and -independent regulation of Syk2007
- Author(s)
  Adachi, T.
- Journal Title
  
  Biochem Biophys Res Commun 364
  
  Pages: 111-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590493
[Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2006
- Author(s)
  Devi, S.S., Hagiyama, H., Adachi, T., Miyasaka, N., Tsubata, T.
- Journal Title
  
  Signal Transduction 6・1
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17028012
[Journal Article] Bispecific antibodies against modified protein and DNA with oxidized lipids.2006
- Author(s)
  Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Kawai, Y., Ishino, K, Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA In print
- Data Source
  KAKENHI-PROJECT-17028012
[Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2006
- Author(s)
  Devi, S.S., Hagiyama, H., Adachi, T., Miyasaka, N., Tsubata, T.
- Journal Title
  
  Signal Transduction 6・1
  
  Pages: 54-61
- Data Source
  KAKENHI-PROJECT-16017235
[Journal Article] Bispecific antibodies against modified protein and DNA with oxidized lipids.2006
- Author(s)
  Akagawa, M., Ito, S., Toyoda, K., Ishii, Y., Tatsuda, E., Shibata, T., Kawai, Y., Ishino, K., Kishi, Y., Adachi, T., Tsubata, T., Takasaki, Y., Hattori, N., Matsuda, T., Uchida, K.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA In print
- Data Source
  KAKENHI-PROJECT-16017235
[Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2005
- Author(s)
  Devi, S.S., Hagiyama, H., Adachi, T., Muyasaka, N., Tsubata, T.
- Journal Title
  
  Signal Transduction 6
  
  Pages: 54-61
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes.2005
- Author(s)
  Devi, S.S., Hagiyama, H., Adachi T., Muyasaka, N., Tsubata, T.
- Journal Title
  
  Signal Transduction 6
  
  Pages: 54-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] The tumor suppressor p53 is not required for antigen receptor-mediate apoptosis of B lymphocytes.2005
- Author(s)
  Devi, S.S., Hagiyama, H., Adachi, T., Muyasaka, N., Tsubata, T.
- Journal Title
  
  Signal Transduction (in press)
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] Involvement of cell cycle progression in survival signaling through CD40 in B lymphocyte line WEHI-2312004
- Author(s)
  Hirai, H., Adachi, T., Tsubata, T.
- Journal Title
  
  Cell Death Differ. 11
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-16017235
[Journal Article] Involvement of cell cycle progression in survival signaling through CD40 in B lymphocyte line WEHI-2312004
- Author(s)
  Hirai, H., Adachi, T., Tsubata, T.
- Journal Title
  
  Cell Death Differ. 11
  
  Pages: 261-269
- Data Source
  KAKENHI-PROJECT-16043219
[Journal Article] Inhibitory co-receptors activated by antigens but not by anti immunoglobulin heavy chain antibodies install requirement of co-stimulation through CD40 for survival and proliferation of B cells.2003
- Author(s)
  Hokazono, Y.Adachi, T., Wabl, M., Tada, N., Amagasa, T., Tsubata, T.
- Journal Title
  
  J.Immunol 171
  
  Pages: 1835-1843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] Involvement of cell cycle progression in survival signaling through CD40 in B lymphocyte line WEHI-231.2003
- Author(s)
  Hirai, H., Adachi, T., Tsubata, T.
- Journal Title
  
  Cell.Death.Differ 11
  
  Pages: 261-269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] Inhibitory co-receptors activated by antigens but not by anti immunoglobulin heavy chain antibodies install requirement of co-stimulation through CD40 for survival and proliferation of B cells.2003
- Author(s)
  Hokazono, Y., Adachi, T., Wabl, M., Tada, N., Amagasa, T., Tsubata' T.
- Journal Title
  
  J.Immunol. 171
  
  Pages: 1835-1843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] Involvement of cell cycle progression in survaival signaling through CD40 inB lymphocyte line WEHI-231.2003
- Author(s)
  Hirai, H., Adachi, T., Tsubata, T.
- Journal Title
  
  Cell.Death.Differ 11
  
  Pages: 261-269
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390158
[Journal Article] Differential Phosphorylation of Functional Tyrosines in CD19 Modulates B Lymphocyte Activation
- Author(s)
  Ishiura, N., Nakashima, H., Watanabe, R., Kuwano, Y., Adachi, T., Takahashi, Y., Tsubata, T., Okochi, H., Tamaki, K., Tedder, T. F., Fujimoto, M.
- Journal Title
  
  Eur J Immunol
  
  Volume: 40 Pages: 1192-204
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] 消化管によるcinnamtannin A2の認識機構の探索2018
- Author(s)
  羽里直幹、黒木麻由、難波文男、戸田登志也、安達貴弘、越阪部奈緒美
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 食シグナルおよび未病の生体イメージング解析2018
- Author(s)
  安達貴弘
- Organizer
  第５回先進イメージング医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 味噌より分離したTetragenococcus halophilus の免疫調整機能2018
- Author(s)
  熊澤利彦、西村篤寿、浅井紀之、安達貴弘
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 生体イメージングによる食シグナルおよび超早期未病の可視化解析2018
- Author(s)
  安達貴弘
- Organizer
  日本農芸化学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 生体イメージングによる超早期未病および腸管センシングの解析2018
- Author(s)
  安達貴弘
- Organizer
  第１５回レドックス・ライフイノベーションシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Intravital imaging of cellular signaling in immune cells．The 3rd International Symposium on Stem Cell Traits and Developmental Systems2018
- Author(s)
  安達貴弘
- Organizer
  KEY Forum 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 生体イメージングによる超早期未病、および食シグナルの可視化解析2018
- Author(s)
  安達貴弘
- Organizer
  日本平滑筋学会若手の会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A2017
- Author(s)
  Takashi Nagaishi, Naoya Tsugawa, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe
- Organizer
  The 11th International Gastrointestinal Consensus Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] IgA Deficiency Induces Spontaneous Inflammation in the Ileum2017
- Author(s)
  Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe
- Organizer
  FOCIS 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice2017
- Author(s)
  Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama
- Organizer
  第４６回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Verification of immunoglobulin A regulation of mucosal microflora and homeostasis2017
- Author(s)
  Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
- Organizer
  第４６回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 腸管免疫細胞および食シグナルの可視化解析2017
- Author(s)
  安達貴弘
- Organizer
  第7回オルソオルガノジェネシス検討会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging2017
- Author(s)
  Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
- Organizer
  第４６回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 腸管免疫細胞および食シグナルの可視化解析2017
- Author(s)
  安達貴弘
- Organizer
  第26回内毒素・LPS研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] IgAの欠損は回腸粘膜特異的な炎症を誘発する2017
- Author(s)
  渡部太郎、永石宇司、Jose Nisha、東海有沙、細谷明徳、　安達貴弘、渡辺守
- Organizer
  日本消化管学会
- Place of Presentation
  名古屋国際会議場、名古屋、愛知
- Year and Date
  2017-02-17
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 生体イメージングによる腸管でのシグナル可視化解析2016
- Author(s)
  安達貴弘
- Organizer
  日本食品免疫学会
- Place of Presentation
  東京大学、文京区、東京
- Year and Date
  2016-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] IN VIVO VISUALIZATION OF Ca2+ DYNAMICS OF MYOEPITHELIAL CELLS IN LACRIMAL GLAND2016
- Author(s)
  Kai Jin, Toshihiro Imada, Yusuke Izuta, Shigeru Nakamura, Takahiro Adachi, Kazuo Tsubota
- Organizer
  8th International Conference on the Tear Film & Ocular Surface:Basic Science and Clinical Relevance
- Place of Presentation
  Conference Centre & Berlioz Opera House、Montpellier, France
- Year and Date
  2016-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Visualization of immune responses by intravital imaging of Ca2+ signals2016
- Author(s)
  ADACHI Takahiro, KARASUYAMA Hajime , YOSHIKAWA Soichiro
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター,宜野湾、沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] CRISPR/Cas9-mediated mutations in mouse IgA locus and its characterization2016
- Author(s)
  渡部太郎、永石宇司、Jose Nisha、東海有沙、細谷明徳、　小島裕大、安達貴弘、渡辺守
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター,宜野湾、沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Effects of fermented food on immune response and gut microbiota of human faecal flora-associated (HFA) mice2016
- Author(s)
  TSUJI Noriko M, KAMIYA Tomonori, WATANABE yohei,KAKUTA Shigeru, ADACHI Takahiro
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄コンベンションセンター,宜野湾、沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] ”管として生きる”個体の腸内環境と免疫機能2016
- Author(s)
  辻典子、平山和宏、渡邉要平、神谷知憲、藍原祥子、角田茂、安達　貴弘
- Organizer
  日本消化吸収学会
- Place of Presentation
  神戸ポートピアホテル、神戸、兵庫
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] プロポリスによる生体内での腸管免疫細胞活性化アルタイム評価2016
- Author(s)
  安達貴弘
- Organizer
  日本食品科学工学会
- Place of Presentation
  名城大学、名古屋、愛知
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice2015
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, KARASUYAMA Hajime, ONODERA Taishi, TAKAHASHI Yoshimasa, KIKUTA Junichi, ISHII Masaru, TEDDER F. Thomas
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター,札幌,北海道
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice2015
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, KARASUYAMA Hajime, ONODERA Taishi, TAKAHASHI Yoshimasa, KIKUTA Junichi, ISHII Masaru, TEDDER F. Thomas
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター,札幌,北海道
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K08526
[Presentation] 生体イメージングによる腸管免疫細胞の動態・活性化の解析2013
- Author(s)
  安達貴弘
- Organizer
  日本食品免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-25113708
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator2013
- Author(s)
  Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama
- Organizer
  国際免疫学会
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PUBLICLY-25113708
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded calcium indicator2013
- Author(s)
  Takahiro ADACHI, Soichiro YOSHIKAWA, Hajime KARASUYAMA, Taishi ONODERA
- Organizer
  日本免疫学会
- Place of Presentation
  幕張（千葉）
- Data Source
  KAKENHI-PUBLICLY-25113708
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded calcium indicator2013
- Author(s)
  Takahiro ADACHI, Soichiro YOSHIKAWA, Hajime KARASUYAMA, Taishi ONODERA
- Organizer
  日本免疫学会
- Place of Presentation
  幕張（千葉）
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator2013
- Author(s)
  Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama
- Organizer
  国際免疫学会
- Place of Presentation
  ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] 生体イメージングによる腸管免疫細胞の動態・活性化の解析2013
- Author(s)
  安達貴弘
- Organizer
  日本食品免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] In vivo imaging of B cell activity in a genetically encoded calcium indicator YC3.60 reporter mouse line2012
- Author(s)
  Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama
- Organizer
  日本免疫学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] 腸管免疫細胞の活性化モニターリングマウスの樹2012
- Author(s)
  安達貴弘
- Organizer
  日本農芸化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] 腸管免疫細胞の活性化モニターリングマウスの樹立2012
- Author(s)
  安達貴弘
- Organizer
  日本食品免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] 腸管免疫細胞の活性化モニターリングマウスの樹立2012
- Author(s)
  安達貴弘
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] Analysis of signaling through the B cell antigen receptor in memory B cells2011
- Author(s)
  Adachi, T.
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] Signaling through the B cell antigen receptor on memory B cells2011
- Author(s)
  Adachi, T.
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] 記憶B細胞における抗原受容体を介したシグナリング2011
- Author(s)
  安達貴弘
- Organizer
  日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-12-04
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] 記憶B細胞における抗原受容体を介したシグナリングの解析2009
- Author(s)
  安達貴弘
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21590529
[Presentation] CD22による糖鎖リガンド依存的およびひ依存的なB細胞抗原受容体シグナル伝達制御2008
- Author(s)
  安達貴弘
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19590493
[Presentation] CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白質抗原が必要である2007
- Author(s)
  安達貴弘
- Organizer
  日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-12-03
- Data Source
  KAKENHI-PROJECT-19590493
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, ONODERA Taishi,TAKAHASHI Yoshimasa, KARASUYAMA Hajime
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, ONODERA Taishi,TAKAHASHI Yoshimasa, KARASUYAMA Hajime
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PUBLICLY-25113708
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, ONODERA Taishi,TAKAHASHI Yoshimasa, KARASUYAMA Hajime
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590575
[Presentation] In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator
- Author(s)
  ADACHI Takahiro, YOSHIKAWA Soichiro, ONODERA Taishi,TAKAHASHI Yoshimasa, KARASUYAMA Hajime
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25113708

1. TSUBATA Takeshi (80197756)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
2. NAKAMURA Ryo (70023398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUDA Tsukasa (20144131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. AIBA Yuichi (00273516)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KITAMURA Daisuke (70204914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUROSAKI Tomohiro (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上阪等 (00251554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 内田浩二 (40203533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 赤池孝章 (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 上原孝 (00261321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 越阪部奈緒美 (30554852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平修 (30416672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUJIMURA Tatsuhito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. RETH Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. RAJEWSKY Klaus

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HOWARD Maure

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SASANO Tetsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. ITO Nobutoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 永石宇治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 烏山一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 中村哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 古川哲史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 菊田順一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 角田茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 辻典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 平山和宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ADACHI Takahiro 安達 貴弘

Research Projects

Research Products

Co-Researchers

Neurophysical approach in beneficial physiological changes induced by the specific taste through the axes of digestive tract, brain and peripheral tissuesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Life science basis of short-lived reactive species originated from foodsOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualizatiion of immune responses by 5D intravital imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

免疫担当細胞の活性化の可視化とそれを用いた免疫反応の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

maintenance and activation mechanisms of memory B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the robust antibody-production of memory B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of activation, maintenance and antibody production of IgE positive B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞周期停止によるアポトーシスにおける蛋白質分解系の機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

共受容体による免疫グロブリンクラス特異的なB細胞活性化制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

メモリーB細胞活性化制御の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of membrane-bound lectins in the regulation of immune cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of cell cycle arrest-induced apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膜蛋白質CD72によるB細胞活性化制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

ADACHI Takahiro 安達貴弘