AOYAMA Toshifumi 青山俊文

Researcher Number	50231105
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2014 – 2019: 信州大学, 学術研究院医学系, 教授 2010 – 2013: 信州大学, 医学系研究科, 教授 2007 – 2008: Shinshu University, 医学系研究科, 教授 2004: Shinshu University Graduate School of Medicine, Department of Metabolic Regulation, Institute on Aging and Adaptation, Professor, 医学研究科, 教授 2004: 信州大学, 大学院・医学研究科・加齢適応医科学専攻, 教授 … More
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Pathological medical chemistry / Biological Sciences / 物質生物化学 Except Principal Investigator Hygiene / General pharmacology / Public health/Health science / Ophthalmology / General medical chemistry / Obstetrics and gynecology … More
Keywords	Principal Investigator PPAR / ワクシニアウイルス / cDNA発現 / C型肝炎 / 酸化ストレス / 極長鎖脂肪酸アシルCoA脱水素酵素 / コア蛋白 / 肝発癌 / ミトコンドリア膨満 / 脂肪肝 … More Except Principal Investigator PPARα / 酸化ストレス / 2,4-dichlorophenoxyacetic acid / 代謝 / ラット / アポトーシス / ノックアウトマウス / 慢性腎臓病 / シトクロムP450 / 喫煙 / 飲酒 / 骨髄 / トリクロロエチレン / TUNEL法 / ミトコンドリア / ペルオキシソーム増殖剤活性化受容体 / 脂肪酸代謝 / マウス / テストステロン / reproductive toxicity / testosterone / PPARalpha / AhR / スルファチド / グルタチオンS-トランスフェラーゼ / 食道癌 / ポリモルフィズム / ベンツピレン / アルデヒド脱水素酵素 / ホルムアルデヒド / 抱水クロラール / 精巣障害 / 肝障害 / 鼻腔癌 / 視神経 / アルデヒド脱水素酵素2 / アルデヒド類 / 遺伝子 / ヒト / 2-ブロモプロパン / 卵巣 / 汎血球減少症 / 末梢血液像 / HE染色 / 骨髄障害 / 生殖障害 / 早期影響指標 / PPARα遺伝子 / 免疫組織化学 / エタノール / PPARα遺伝子ノックアウトマウス / 高インスリン血症 / 糖尿病 / LDL受容体 / 肥満 / 膵臓 / 白色脂肪組織 / 肝臓 / 糖尿症 / 腎臓 / 糸球体腎炎 / 尿細管間質障害 / 炎症反応 / 尿細管障害 / 腎保護 / 脂肪酸 / 炎症 / アンギオテンシンⅡレセプター拮抗薬 / ＰＰＡＲα / ＡＲＢ / イルベサルタン / 尿細管 / 蛋白尿 / 有機溶剤 / ヒト肝 / ヒト肺 / 毒性 / 有機溶剤の代謝 / トルエン / スチレン / キシレン / ヒトチトクロームP450 / マウスチトクロームP450 / ラットチトクロームP450 / ベンゼン / フェノール / 代謝活性化 / 種差 / ワクシニアウイルス / ヒトP450 / cytochrome P450 / organic solvents / human liver / human lungs / metabolism / toxicity / smoking / drinking / チトクローム P450 / 子宮内膜 / 子宮体癌 / RT-PCR / チトクロームP450 / チトクロ-ムP450 / PCR / Gynecologic Carcinoma / Carcinogenesis / Cytochrome P450 / 脂肪酸酸化系新酵素 / 酵素欠損 / mitochondria / fatty acid oxidation enzymes / inborn errors of mettabolism / ペルオキシゾーム / 転写調節 / 形態形成 / 細胞小器官 / Peroxisomes / transcripton factor / morphogenesis / cell organnelles / フタル酸ジューエチルヘキシン / 生殖毒性 / 陰膳 / 内分泌撹乱作用 / 1日の摂取量 / フタル酸ジ2-エチルヘキシル / Peroxisome proliferator activated receptor α / フタル酸ジn-ブチル / フタル酸ブチルベンジル / 食事 / ジエチルフタル酸 / ジブチルフタル酸 / ブチルベンジルフタル酸 / ジシクロヘキシルフタル酸 / ジエチルヘキシルフタル酸 / ジエチルヘキシルアジピン酸 / 2世代生殖毒性実験 / ペルオキシゾーム酵素 / 繁殖率 / di(2-ethylhexyl)phthalate / Meals / endocrine-disrupting chemicals / Intake per day / 2,4-ジクロロフェキノキシ酢酸 / ペンタクロロフェノル / 甲状腺 / 生殖器障害 / ペンタクロロフェノール / 芳香族炭化水素受容体 / ノックアウト / グルクロン酸抱合酵素 / constitutive androstane receptor / トランスサイレチン / 2,4-ジクロロフェノキシ酢酸 / ライディッヒ細胞 / コレステロール合成 / プロゲステロン / 培養細胞 / コレステロール / テストステロン合成系 / コレステロールde novo合成 / セルトリ細胞 / pentachlorophenol / thyroid hormone / knockout mice / 肝細胞癌 / C型肝炎ウイルス / コア蛋白 / 脂肪沈着 / PPAR-α / hepatitis C virus (HCV) / HCV core protein / steatosis / hepatocellular carcinoma (HCC) / 非アルコール性脂肪肝炎 / 核内受容体 / メタボロミクス / コレステロール毒性 / CD44 / マイクロアレイ解析 / 腸管・肝臓連関 / 疾患モデル動物 / 肝臓病学 / 脂質 / 病理学 / 栄養学 / 生体分子 / 心臓血管病 / バイオマーカー / 尿毒素 / 高血圧 / 高脂血症 / 不飽和脂肪酸 / 複合糖脂質 Less

Clinical significance and mechanism of serum sulfatide abnormalities in chronic kidney diseaseOngoing
- Principal Investigator
  
  上條祐司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shinshu University
Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive methodPrincipal Investigator
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolism
- Principal Investigator
  
  TANAKA Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids
- Principal Investigator
  
  Nakajima Takero
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shinshu University
Development of a new CKD therapy aimed for renoprotection by renal PPARalpha activation
- Principal Investigator
  
  KAMIJO Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Development of prevention methods for hepatitis C - related liver tumor focusing function of nuclear receptor PPARPrincipal Investigator
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Development of the novel therapy against chronic kidney disease that utilizes PPAR α agonist
- Principal Investigator
  
  KAMIJO Yuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methodsPrincipal Investigator
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
The role of hepatitis C infection and proliferators-activated receptor alpha protects (PPA α) in occurrence of hepatocellular carcinoma
- Principal Investigator
  
  KIYOSAWA Kendo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Shinshu University School of Medicine
C型肝炎ウイルス感染による多中心的肝発癌に対する新たな予防法の開発Principal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
Adverse effects of endocrine-disrupting chemicals and the mechanism via nuclear receptor in relation to the risk assessment
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Nagoya University
C型肝炎ウイルス・コア蛋白による多中心的肝癌発生機構の解明Principal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
核内受容体を介したインスリン分泌および肥満調節機構の解明
- Principal Investigator
  
  原厚
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Shinshu University
新しい緑内障動物モデルの確立と網膜神経節細胞の慢性細胞死の分子機構解析
- Principal Investigator
  
  吉村長久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Shinshu University
Elucidation of mechanisms of steatosis and inflammation by alcohol ingestion or HCV core proteinPrincipal Investigator
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Reproductive toxicity of endocrine-disrupting chemicals and the mechanism via peroxisome proliferators-activated receptor in relation to the risk assessment
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Nagoya University
  Shinshu University
2-ブロモプロパンによる骨髄のアポトーシスと毒性評価における意義
- Principal Investigator
  
  那須民江
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Public health/Health science
- Research Institution
  Shinshu University
The study on the morphogenesis of peroxisomes by the inhibition of the expression of transcription factors, PPARs.
- Principal Investigator
  
  USUDA Nobuteru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Shinshu University
アルデヒド脱水素酸素2の遺伝子多型性と有機溶剤の代謝・毒性との関連性
- Principal Investigator
  
  那須民江 (中島民江)
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Shinshu University
ヒトおよびマウスの極長鎖脂肪酸アシルCoA脱水素酵素ゲノムDNAのクローニングPrincipal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
極長鎖脂肪酸アシルCoA脱水素酵素欠損症患者の遺伝子解析Principal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
食道粘膜における化学発癌物質の直接的の発癌作用の証明
- Principal Investigator
  
  那須民江
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Shinshu University
ヒトP450によるダイオキシン,ダイベンゾフランの変異原性活性化Principal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Shinshu University
Physiological and pathological roles of new mitochondrial fatty acid oxidation enzymes
- Principal Investigator
  
  HASHIMOTO Takashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinsyuu University
Transfer of overexpressed protein into organelle and its regulation mechanismPrincipal Investigator
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Shinshu University
ワクシニアウイルス法により合成されたヒトP450によるニトロソ化合物の活性化Principal Investigator
- Principal Investigator
  
  青山俊文
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Shinshu University
HUMAN CYTOCHROME P450 ISOZYMES RESPONSIBLE FOR THE METABOLISM OF ORGANIC SOLVENTS AND THEIR ROLES IN THE TOXICITY
- Principal Investigator
  
  MURAYAMA Ninzo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  SHINSHU UNIVERSITY
Role of Oncogene and Cytochrome P450 in Carcinogenesis of Gynecologic carcinoma
- Principal Investigator
  
  KIKKAWA Fumitaka
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University

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All Journal Article Presentation Book

[Book] 疾患モデルの作成と利用　脂質代謝異常と関連疾患（上巻）2015
- Author(s)
  中嶌岳郎、上條祐司、田中直樹、青山俊文　ほか
- Total Pages
  477
- Publisher
  株式会社　エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-25460329
[Book] 目で見る解剖と生理・11巻消化系II2010
- Author(s)
  青山俊文
- Total Pages
  35
- Publisher
  医学映像教育センター
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.2019
- Author(s)
  Wang X, Tanaka N, Hu X, Kimura T, Lu Y, Jia F, Sato Y, Nakayama J, Moriya K, Koike K, Aoyama T
- Journal Title
  
  Arch Toxicol.
  
  Volume: in press
- DOI
  10.1007/s00204-019-02440-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08616
[Journal Article] Effects of Hypertension and Antihypertensive Treatments on Sulfatide Levels in Serum and Its Metabolism2019
- Author(s)
  Guo Ran、Hu Xiao、Yamada Yosuke、Harada Makoto、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
- Journal Title
  
  Hypertens Res.
  
  Volume: 42 Pages: 598-609
- DOI
  10.1038/s41440-018-0160-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
[Journal Article] Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice.2019
- Author(s)
  Lu Y, Harada M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Kyogashima M, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 93 Pages: 149-161
- DOI
  10.1007/s00204-018-2335-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08204
[Journal Article] Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.2019
- Author(s)
  Yamada Yosuke、Harada Makoto、Hashimoto Koji、Guo Ran、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
- Journal Title
  
  Glycoconj J.
  
  Volume: 36 Pages: 1-11
- DOI
  10.1007/s10719-018-9850-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
[Journal Article] Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene2017
- Author(s)
  Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 33 Pages: 927-936
- DOI
  10.1007/s10719-016-9703-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08264, KAKENHI-PROJECT-16K08616
[Journal Article] Decreased Fatty Acid <i>β</i>-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice2017
- Author(s)
  Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 242(3) Issue: 3 Pages: 229-239
- DOI
  10.1620/tjem.242.229
- NAID
  130005808367
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Activation of PPAR<i>α</i> by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis2016
- Author(s)
  Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 240 Issue: 2 Pages: 113-122
- DOI
  10.1620/tjem.240.113
- NAID
  130005245903
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Fatty acid accumulation and resulting PPARα activation in fibroblasts due to trifunctional protein deficiency2012
- Author(s)
  Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Tian YY, Kimura T, Aoyama T
- Journal Title
  
  PPAR Res
  
  Volume: 2012 Pages: 371691-371691
- DOI
  10.1155/2012/371691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] PPARalpha is down-regulated following liver transplantation in mice2012
- Author(s)
  Nakagawa K, Tanaka N, Morita M, Sugioka A, Miyagawa S, Gonzalez FJ, Aoyama T
- Journal Title
  
  Journal of Hepatology
  
  Volume: 56 Pages: 586-594
- DOI
  10.1016/j.jhep.2011.08.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] PPAR α activation protects against anti-Thy1 nephritis by suppressing glomerular NF-κB signaling.2012
- Author(s)
  Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T
- Journal Title
  
  PPAR Res.
  
  Volume: 2012 Pages: 1-11
- DOI
  10.1155/2012/976089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060, KAKENHI-PROJECT-22590238
[Journal Article] Hepatic cerebroside sulfotransferase is induced by PPARα activation in mice2012
- Author(s)
  Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T
- Journal Title
  
  PPAR Res
  
  Volume: 2012 Pages: 174932-174932
- DOI
  10.1155/2012/174932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress2012
- Author(s)
  Sheng XN, Nakajima T, Wang LX, Zhang XW, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 227 Issue: 1 Pages: 1-12
- DOI
  10.1620/tjem.227.1
- NAID
  10030613055
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPAR in mice2012
- Author(s)
  Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li YF, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T
- Journal Title
  
  Archives of Toxicology
  
  Volume: 86 Pages: 63-74
- DOI
  10.1007/s00204-011-0704-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060, KAKENHI-PROJECT-22790543, KAKENHI-PROJECT-23390183
[Journal Article] Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels.2012
- Author(s)
  Kamijo Y, Wang LX, Matsumoto A,Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A
- Journal Title
  
  Clin Exp Nephrol
  
  Volume: 16 Pages: 959-967
- DOI
  10.1007/s10157-012-0634-2
- NAID
  10031145928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] Effect of bezafibrate on hepatic oxidative stress2010
- Author(s)
  青山俊文
- Journal Title
  
  Redox Report
  
  Volume: 15 Pages: 123-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] Down-regulation of SREBP-lc is associated with the development of bur ned-out NASH2010
- Author(s)
  青山俊文
- Journal Title
  
  J Hepatology
  
  Volume: 53 Pages: 724-731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390060
[Journal Article] peroxisome proliferators-activated receptor alpha Protects against alcohol-induced liver damage.2004
- Author(s)
  Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Hepatology 40
  
  Pages: 972-980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590633
[Journal Article] Peroxisome proliferators-activated receptor a protects against alcohol-induced liver damage.2004
- Author(s)
  Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Hepatology 40(4)
  
  Pages: 972-980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370121
[Journal Article] C聖肝炎ウイルスによる肝癌発症のメカニズム-PPARαの役割2004
- Author(s)
  田中直樹, 青山俊文
- Journal Title
  
  日本臨牀 62
  
  Pages: 20-25
- Data Source
  KAKENHI-PROJECT-15590633
[Journal Article] PPARαと脂肪代謝異常2004
- Author(s)
  田中直樹, 青山俊文
- Journal Title
  
  Medical Science Disease 30
  
  Pages: 62-65
- Data Source
  KAKENHI-PROJECT-15590633
[Journal Article] C型肝炎ウイルスによる肝細胞癌発症のメカニズム-PPARαの役割2004
- Author(s)
  田中直樹, 青山俊文
- Journal Title
  
  Cancer 101
  
  Pages: 1616-1622
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590633
[Journal Article] In vitro stabilization of nuclear retinoide X receptor alpha in the presence of peroxisome proliferators-activated receptor alpha.2003
- Author(s)
  Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T.
- Journal Title
  
  FEBS Lett 543
  
  Pages: 120-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590633
[Journal Article] Functional activation of peroxisome proliferator-activated recept or a (PPARa) by environmental chemicals in relation to their toxicities2002
- Author(s)
  Nakajima T, Ichihara G, Kamijima M, Aoyama T
- Journal Title
  
  Nagoya J 65
  
  Pages: 85-94
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370121
[Journal Article] Functional activation of peroxisome proliferators-activated receptor α(PPAR α) by environmental chemicals in relation to their toxicities.2002
- Author(s)
  Nakajima T, Ichihara G, Kamijima M, Aoyama T.
- Journal Title
  
  Nagoya J 65
  
  Pages: 85-94
- NAID
  110000023230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370121
[Journal Article] Identification of functions of peroxisome proliferators-activated receptor a in proximal tubules.2002
- Author(s)
  Kamijo Y, Hora K, Tanaka N, Usuda N, Kiyosawa K, Nakajima T, Gonzalez FJ, Aoyama T.
- Journal Title
  
  J Am Soc Nephrol 13
  
  Pages: 1692-1702
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370121
[Journal Article] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARa-null mice through attenuation of increases in oxidative stress
- Author(s)
  Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez F J, Aoyama T
- Journal Title
  
  J Hepatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590301
[Presentation] EFFECTS OF HYPERTENSION AND ANTIHYPERTENSIVE TREATMENTS ON SULFATIDE LEVELS IN SERUM AND ITS METABOLISM2019
- Author(s)
  Y. Kamijo, R. Guo, Y. Yamada, M. Harada, T. Nakajima, K. Hashimoto, T. Kashihara, Y. Mitsuhiko, T. Aoyama
- Organizer
  国際腎臓学会（WCN 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08204
[Presentation] PPARαがコレステロール過剰摂取による血管内凝固作用を軽減する2018
- Author(s)
  上條祐司、山田洋輔、山口晃典、園田光佑、山田愛子、藤井一聡、原悠太、増田知恵、藤田識志、小川洋平、橋本幸始、中嶌岳郎、青山俊文
- Organizer
  第61回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-18K08204
[Presentation] 5/6腎摘慢性腎臓病モデルマウスにおける血清スルファチド低下メカニズムの解明2018
- Author(s)
  山田洋輔、橋本幸始、上條祐司、中嶌岳郎、青山俊文
- Organizer
  第61回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-18K08204
[Presentation] イルベサルタンはマウス腎においてペルオキシソーム増殖剤活性化受容体alphaを介した腎保護作用を有する2016
- Author(s)
  原田真、橋本幸始、山田洋輔、中嶌岳郎、青山俊文、上條祐司
- Organizer
  第59回日本腎臓学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-06-19
- Data Source
  KAKENHI-PROJECT-25460329
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxida tive stress2009
- Author(s)
  Tanaka N, Okiyama W, Aoyama T
- Organizer
  19^<th> conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Hong Kong
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19590301

1. NASU Tamie (10020794)

# of Collaborated Projects: 11 results

# of Collaborated Products: 4 results
2. HARA Atsushi (70126697)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. TANAKA Naoki (80419374)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. KAMIJO Yuji (50377636)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
5. ICHIHARA Gaku (90252238)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Nakajima Takero (30581011)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. MURAYAMA Ninzo (90020718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KIKKAWA Fumitaka (40224985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWAI Michiyasu (10234014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HASHIMOTO Takashi (80009935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FURUTA Shuichi (80126705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAZAWA Shoko (20020745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. USUDA Nobuteru (30135123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UEMUBA Keiichi (80012756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAYAMA Jun (10221459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUKUSHIMA Yoshimitsu (70273084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OMURA Minoru (50243936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KIYOSAWA Kendo (30020829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. TANAKA Eiji (50163506)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. YOSHIZAWA Kaname (90220615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAKAMURA Kozo (20345763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 吉村長久 (70211662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 黒岩さち子 (60313863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 太田浩一 (70262730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 加納武夫 (50169596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SASAKI Kazutoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Gonzalez Frank j

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TAKAHASHI Shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 山田充彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

AOYAMA Toshifumi 青山 俊文

Research Projects

Research Products

Co-Researchers

Clinical significance and mechanism of serum sulfatide abnormalities in chronic kidney diseaseOngoing

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Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive methodPrincipal Investigator

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Development of prevention methods for hepatitis C - related liver tumor focusing function of nuclear receptor PPARPrincipal Investigator

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Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methodsPrincipal Investigator

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C型肝炎ウイルス感染による多中心的肝発癌に対する新たな予防法の開発Principal Investigator

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C型肝炎ウイルス・コア蛋白による多中心的肝癌発生機構の解明Principal Investigator

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AOYAMA Toshifumi 青山俊文