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AOYAMA Toshifumi  青山 俊文

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Researcher Number 50231105
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2014 – 2019: 信州大学, 学術研究院医学系, 教授
2010 – 2013: 信州大学, 医学系研究科, 教授
2007 – 2008: Shinshu University, 医学系研究科, 教授
2004: Shinshu University Graduate School of Medicine, Department of Metabolic Regulation, Institute on Aging and Adaptation, Professor, 医学研究科, 教授
2004: 信州大学, 大学院・医学研究科・加齢適応医科学専攻, 教授 … More
2003 – 2004: 信州大学, 大学院・医学研究科, 教授
1998 – 2003: 信州大学, 医学部, 教授
1991 – 1997: 信州大学, 医学部, 助教授
1992: 信州大学医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Pathological medical chemistry / Biological Sciences / 物質生物化学
Except Principal Investigator
Hygiene / General pharmacology / Public health/Health science / Ophthalmology / General medical chemistry / Obstetrics and gynecology … More / Pathological medical chemistry / General anatomy (including Histology/Embryology) / Gastroenterology / Experimental pathology / General medical chemistry / Basic Section 53040:Nephrology-related Less
Keywords
Principal Investigator
PPAR / ワクシニアウイルス / cDNA発現 / C型肝炎 / 酸化ストレス / 極長鎖脂肪酸アシルCoA脱水素酵素 / コア蛋白 / 肝発癌 / ミトコンドリア膨満 / 脂肪肝 … More / PMP70 / PPARα / ヒトP450 / ニトロソ化合物 / 変異原性活性化 / エ-ムステスト / 6チオグアニン / ユ-カリオ-トミュ-タジェネシス / TCDD / チトクロームP450 / DNAアダクト / 代謝活性化 / 脂肪酸代謝異常 / 脂肪酸アシルCoA脱水素酵素 / in frame deletion / RT-PCR / double deletion / exon skipping / PCR / 脂肪酸β酸化 / ミトコンドリア / スプライシング異常 / マッピング / エンハンサー / イントロン / エクソンスキッピング / 癌 / ウィルス / シグナル伝達 / 核内受容体 / アポトーシス / 長鎖脂肪酸 / C型肝炎ウイルス / 多中心性 / トランスジェニックマウス / レトロウイルス / アルコール / レシチン / 肝障害 / 炎症 / NF-kB / NF-κB / エタノール / 肝炎 / リアルタイムPCR / 胃粘膜 / 野生型マウス / ケモカイン / 分子腫瘍学 / C 型肝炎 / アンタゴニスト / 中性脂肪 / HCVコア蛋白 / HCC / フィブレート / EPA / PPAR活性化 / ミトコンドリア障害 / フィブラート / アシルCoA脱水素酵素 / アシルCoAオキシダーゼ / 過剰発現 / オルガネラ内での安定性 / ペルオキシソーム / ワクシニアウイルスベクター / ペルオキシソームへの移行 / Zellweger細胞 / mRNAの安定性 / acyl-CoA dehydrogenase / acyl-CoA oxidase / vaccinia virus / overexpression / stability in organelle / cDNA-expression / peroxisome / C型肝炎ウイルス・コア蛋白 / CuZnSOD / β酸化酵素 / 繊維化 / Mitochondria swelling / Hepatitis C virus core protein / Fatty liver / Cu Zu SOD / Oxidative stress / βOxidation enzymes / Fibrosis / HCV / トランス脂肪酸 / 肝がん / C型肝炎ウイルスコア蛋白 / PPARalpha / デオキシコール酸 / トランス脂肪酸食 / 肝臓非癌部・癌部 / スルファチド / 脂質 / 発癌 … More
Except Principal Investigator
PPARα / 酸化ストレス / 2,4-dichlorophenoxyacetic acid / 代謝 / ラット / アポトーシス / ノックアウトマウス / 慢性腎臓病 / シトクロムP450 / 喫煙 / 飲酒 / 骨髄 / トリクロロエチレン / TUNEL法 / ミトコンドリア / ペルオキシソーム増殖剤活性化受容体 / 脂肪酸代謝 / マウス / テストステロン / reproductive toxicity / testosterone / PPARalpha / AhR / スルファチド / グルタチオンS-トランスフェラーゼ / 食道癌 / ポリモルフィズム / ベンツピレン / アルデヒド脱水素酵素 / ホルムアルデヒド / 抱水クロラール / 精巣障害 / 肝障害 / 鼻腔癌 / 視神経 / アルデヒド脱水素酵素2 / アルデヒド類 / 遺伝子 / ヒト / 2-ブロモプロパン / 卵巣 / 汎血球減少症 / 末梢血液像 / HE染色 / 骨髄障害 / 生殖障害 / 早期影響指標 / PPARα遺伝子 / 免疫組織化学 / エタノール / PPARα遺伝子ノックアウトマウス / 高インスリン血症 / 糖尿病 / LDL受容体 / 肥満 / 膵臓 / 白色脂肪組織 / 肝臓 / 糖尿症 / 腎臓 / 糸球体腎炎 / 尿細管間質障害 / 炎症反応 / 尿細管障害 / 腎保護 / 脂肪酸 / 炎症 / アンギオテンシンⅡレセプター拮抗薬 / PPARα / ARB / イルベサルタン / 尿細管 / 蛋白尿 / 有機溶剤 / ヒト肝 / ヒト肺 / 毒性 / 有機溶剤の代謝 / トルエン / スチレン / キシレン / ヒトチトクロームP450 / マウスチトクロームP450 / ラットチトクロームP450 / ベンゼン / フェノール / 代謝活性化 / 種差 / ワクシニアウイルス / ヒトP450 / cytochrome P450 / organic solvents / human liver / human lungs / metabolism / toxicity / smoking / drinking / チトクローム P450 / 子宮内膜 / 子宮体癌 / RT-PCR / チトクロームP450 / チトクロ-ムP450 / PCR / Gynecologic Carcinoma / Carcinogenesis / Cytochrome P450 / 脂肪酸酸化系新酵素 / 酵素欠損 / mitochondria / fatty acid oxidation enzymes / inborn errors of mettabolism / ペルオキシゾーム / 転写調節 / 形態形成 / 細胞小器官 / Peroxisomes / transcripton factor / morphogenesis / cell organnelles / フタル酸ジューエチルヘキシン / 生殖毒性 / 陰膳 / 内分泌撹乱作用 / 1日の摂取量 / フタル酸ジ2-エチルヘキシル / Peroxisome proliferator activated receptor α / フタル酸ジn-ブチル / フタル酸ブチルベンジル / 食事 / ジエチルフタル酸 / ジブチルフタル酸 / ブチルベンジルフタル酸 / ジシクロヘキシルフタル酸 / ジエチルヘキシルフタル酸 / ジエチルヘキシルアジピン酸 / 2世代生殖毒性実験 / ペルオキシゾーム酵素 / 繁殖率 / di(2-ethylhexyl)phthalate / Meals / endocrine-disrupting chemicals / Intake per day / 2,4-ジクロロフェキノキシ酢酸 / ペンタクロロフェノル / 甲状腺 / 生殖器障害 / ペンタクロロフェノール / 芳香族炭化水素受容体 / ノックアウト / グルクロン酸抱合酵素 / constitutive androstane receptor / トランスサイレチン / 2,4-ジクロロフェノキシ酢酸 / ライディッヒ細胞 / コレステロール合成 / プロゲステロン / 培養細胞 / コレステロール / テストステロン合成系 / コレステロールde novo合成 / セルトリ細胞 / pentachlorophenol / thyroid hormone / knockout mice / 肝細胞癌 / C型肝炎ウイルス / コア蛋白 / 脂肪沈着 / PPAR-α / hepatitis C virus (HCV) / HCV core protein / steatosis / hepatocellular carcinoma (HCC) / 非アルコール性脂肪肝炎 / 核内受容体 / メタボロミクス / コレステロール毒性 / CD44 / マイクロアレイ解析 / 腸管・肝臓連関 / 疾患モデル動物 / 肝臓病学 / 脂質 / 病理学 / 栄養学 / 生体分子 / 心臓血管病 / バイオマーカー / 尿毒素 / 高血圧 / 高脂血症 / 不飽和脂肪酸 / 複合糖脂質 Less
  • Research Projects

    (28 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (29 People)
  •  Clinical significance and mechanism of serum sulfatide abnormalities in chronic kidney diseaseOngoing

    • Principal Investigator
      上條 祐司
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Shinshu University
  •  Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive methodPrincipal Investigator

    • Principal Investigator
      AOYAMA Toshifumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolism

    • Principal Investigator
      TANAKA Naoki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Shinshu University
  •  Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids

    • Principal Investigator
      Nakajima Takero
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Shinshu University
  •  Development of a new CKD therapy aimed for renoprotection by renal PPARalpha activation

    • Principal Investigator
      KAMIJO Yuji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Shinshu University
  •  Development of prevention methods for hepatitis C - related liver tumor focusing function of nuclear receptor PPARPrincipal Investigator

    • Principal Investigator
      AOYAMA Toshifumi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  Development of the novel therapy against chronic kidney disease that utilizes PPAR α agonist

    • Principal Investigator
      KAMIJO Yuji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Shinshu University
  •  Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methodsPrincipal Investigator

    • Principal Investigator
      AOYAMA Toshifumi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  The role of hepatitis C infection and proliferators-activated receptor alpha protects (PPA α) in occurrence of hepatocellular carcinoma

    • Principal Investigator
      KIYOSAWA Kendo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Shinshu University School of Medicine
  •  C型肝炎ウイルス感染による多中心的肝発癌に対する新たな予防法の開発Principal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Shinshu University
  •  Adverse effects of endocrine-disrupting chemicals and the mechanism via nuclear receptor in relation to the risk assessment

    • Principal Investigator
      NASU Tamie
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Nagoya University
  •  C型肝炎ウイルス・コア蛋白による多中心的肝癌発生機構の解明Principal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Shinshu University
  •  核内受容体を介したインスリン分泌および肥満調節機構の解明

    • Principal Investigator
      原 厚
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Shinshu University
  •  新しい緑内障動物モデルの確立と網膜神経節細胞の慢性細胞死の分子機構解析

    • Principal Investigator
      吉村 長久
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Shinshu University
  •  Elucidation of mechanisms of steatosis and inflammation by alcohol ingestion or HCV core proteinPrincipal Investigator

    • Principal Investigator
      AOYAMA Toshifumi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  Reproductive toxicity of endocrine-disrupting chemicals and the mechanism via peroxisome proliferators-activated receptor in relation to the risk assessment

    • Principal Investigator
      NASU Tamie
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Nagoya University
      Shinshu University
  •  2-ブロモプロパンによる骨髄のアポトーシスと毒性評価における意義

    • Principal Investigator
      那須 民江
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Public health/Health science
    • Research Institution
      Shinshu University
  •  The study on the morphogenesis of peroxisomes by the inhibition of the expression of transcription factors, PPARs.

    • Principal Investigator
      USUDA Nobuteru
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Shinshu University
  •  アルデヒド脱水素酸素2の遺伝子多型性と有機溶剤の代謝・毒性との関連性

    • Principal Investigator
      那須 民江 (中島 民江)
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hygiene
    • Research Institution
      Shinshu University
  •  ヒトおよびマウスの極長鎖脂肪酸アシルCoA脱水素酵素ゲノムDNAのクローニングPrincipal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  極長鎖脂肪酸アシルCoA脱水素酵素欠損症患者の遺伝子解析Principal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinshu University
  •  食道粘膜における化学発癌物質の直接的の発癌作用の証明

    • Principal Investigator
      那須 民江
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Shinshu University
  •  ヒトP450によるダイオキシン,ダイベンゾフランの変異原性活性化Principal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Shinshu University
  •  Physiological and pathological roles of new mitochondrial fatty acid oxidation enzymes

    • Principal Investigator
      HASHIMOTO Takashi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Shinsyuu University
  •  Transfer of overexpressed protein into organelle and its regulation mechanismPrincipal Investigator

    • Principal Investigator
      AOYAMA Toshifumi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      物質生物化学
    • Research Institution
      Shinshu University
  •  ワクシニアウイルス法により合成されたヒトP450によるニトロソ化合物の活性化Principal Investigator

    • Principal Investigator
      青山 俊文
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Shinshu University
  •  HUMAN CYTOCHROME P450 ISOZYMES RESPONSIBLE FOR THE METABOLISM OF ORGANIC SOLVENTS AND THEIR ROLES IN THE TOXICITY

    • Principal Investigator
      MURAYAMA Ninzo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      SHINSHU UNIVERSITY
  •  Role of Oncogene and Cytochrome P450 in Carcinogenesis of Gynecologic carcinoma

    • Principal Investigator
      KIKKAWA Fumitaka
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nagoya University

All 2019 2018 2017 2016 2015 2012 2010 2009 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] 疾患モデルの作成と利用 脂質代謝異常と関連疾患(上巻)2015

    • Author(s)
      中嶌岳郎、上條祐司、田中直樹、青山俊文 ほか
    • Total Pages
      477
    • Publisher
      株式会社 エル・アイ・シー
    • Data Source
      KAKENHI-PROJECT-25460329
  • [Book] 目で見る解剖と生理・11巻消化系II2010

    • Author(s)
      青山俊文
    • Total Pages
      35
    • Publisher
      医学映像教育センター
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice.2019

    • Author(s)
      Lu Y, Harada M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Kyogashima M, Gonzalez FJ, Aoyama T.
    • Journal Title

      Arch Toxicol.

      Volume: 93 Pages: 149-161

    • DOI

      10.1007/s00204-018-2335-4

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08204
  • [Journal Article] Effects of Hypertension and Antihypertensive Treatments on Sulfatide Levels in Serum and Its Metabolism2019

    • Author(s)
      Guo Ran、Hu Xiao、Yamada Yosuke、Harada Makoto、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
    • Journal Title

      Hypertens Res.

      Volume: 42 Pages: 598-609

    • DOI

      10.1038/s41440-018-0160-z

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
  • [Journal Article] Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.2019

    • Author(s)
      Yamada Yosuke、Harada Makoto、Hashimoto Koji、Guo Ran、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
    • Journal Title

      Glycoconj J.

      Volume: 36 Pages: 1-11

    • DOI

      10.1007/s10719-018-9850-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
  • [Journal Article] A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.2019

    • Author(s)
      Wang X, Tanaka N, Hu X, Kimura T, Lu Y, Jia F, Sato Y, Nakayama J, Moriya K, Koike K, Aoyama T
    • Journal Title

      Arch Toxicol.

      Volume: in press

    • DOI

      10.1007/s00204-019-02440-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08616
  • [Journal Article] Decreased Fatty Acid <i>β</i>-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice2017

    • Author(s)
      Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 242(3) Issue: 3 Pages: 229-239

    • DOI

      10.1620/tjem.242.229

    • NAID

      130005808367

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08264
  • [Journal Article] Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene2017

    • Author(s)
      Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.
    • Journal Title

      Glycoconjugate Journal

      Volume: 33 Pages: 927-936

    • DOI

      10.1007/s10719-016-9703-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08264, KAKENHI-PROJECT-16K08616
  • [Journal Article] Activation of PPAR<i>α</i> by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis2016

    • Author(s)
      Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 240 Issue: 2 Pages: 113-122

    • DOI

      10.1620/tjem.240.113

    • NAID

      130005245903

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08264
  • [Journal Article] Fatty acid accumulation and resulting PPARα activation in fibroblasts due to trifunctional protein deficiency2012

    • Author(s)
      Wakabayashi M, Kamijo Y, Nakajima T, Tanaka N, Sugiyama E, Tian YY, Kimura T, Aoyama T
    • Journal Title

      PPAR Res

      Volume: 2012 Pages: 371691-371691

    • DOI

      10.1155/2012/371691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Attenuation of Kidney Injuries Maintains Serum Sulfatide Levels Dependent on Hepatic Synthetic Ability: A Possible Involvement of Oxidative Stress2012

    • Author(s)
      Sheng XN, Nakajima T, Wang LX, Zhang XW, Kamijo Y, Takahashi K, Tanaka N, Sugiyama E, Kyogashima M, Aoyama T, Hara A
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 227 Issue: 1 Pages: 1-12

    • DOI

      10.1620/tjem.227.1

    • NAID

      10030613055

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Hepatic cerebroside sulfotransferase is induced by PPARα activation in mice2012

    • Author(s)
      Kimura T, Nakajima T, Kamijo Y, Tanaka N, Wang L, Hara A, Sugiyama E, Tanaka E, Gonzalez FJ, Aoyama T
    • Journal Title

      PPAR Res

      Volume: 2012 Pages: 174932-174932

    • DOI

      10.1155/2012/174932

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] PPAR α activation protects against anti-Thy1 nephritis by suppressing glomerular NF-κB signaling.2012

    • Author(s)
      Hashimoto K, Kamijo Y, Nakajima T, Harada M, Higuchi M, Ehara T, Shigematsu H, Aoyama T
    • Journal Title

      PPAR Res.

      Volume: 2012 Pages: 1-11

    • DOI

      10.1155/2012/976089

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060, KAKENHI-PROJECT-22590238
  • [Journal Article] Long-term improvement of oxidative stress via kidney transplantation ameliorates serum sulfatide levels.2012

    • Author(s)
      Kamijo Y, Wang LX, Matsumoto A,Nakajima T, Hashimoto K, Higuchi M, Kyogashima M, Aoyama T, Hara A
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 959-967

    • DOI

      10.1007/s10157-012-0634-2

    • NAID

      10031145928

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPAR&#61537; in mice2012

    • Author(s)
      Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li YF, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T
    • Journal Title

      Archives of Toxicology

      Volume: 86 Pages: 63-74

    • DOI

      10.1007/s00204-011-0704-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060, KAKENHI-PROJECT-22790543, KAKENHI-PROJECT-23390183
  • [Journal Article] PPARalpha is down-regulated following liver transplantation in mice2012

    • Author(s)
      Nakagawa K, Tanaka N, Morita M, Sugioka A, Miyagawa S, Gonzalez FJ, Aoyama T
    • Journal Title

      Journal of Hepatology

      Volume: 56 Pages: 586-594

    • DOI

      10.1016/j.jhep.2011.08.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Down-regulation of SREBP-lc is associated with the development of bur ned-out NASH2010

    • Author(s)
      青山俊文
    • Journal Title

      J Hepatology

      Volume: 53 Pages: 724-731

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] Effect of bezafibrate on hepatic oxidative stress2010

    • Author(s)
      青山俊文
    • Journal Title

      Redox Report

      Volume: 15 Pages: 123-130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390060
  • [Journal Article] C型肝炎ウイルスによる肝細胞癌発症のメカニズム-PPARαの役割2004

    • Author(s)
      田中 直樹, 青山 俊文
    • Journal Title

      Cancer 101

      Pages: 1616-1622

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590633
  • [Journal Article] peroxisome proliferators-activated receptor alpha Protects against alcohol-induced liver damage.2004

    • Author(s)
      Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T.
    • Journal Title

      Hepatology 40

      Pages: 972-980

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590633
  • [Journal Article] Peroxisome proliferators-activated receptor a protects against alcohol-induced liver damage.2004

    • Author(s)
      Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T.
    • Journal Title

      Hepatology 40(4)

      Pages: 972-980

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370121
  • [Journal Article] PPARαと脂肪代謝異常2004

    • Author(s)
      田中 直樹, 青山 俊文
    • Journal Title

      Medical Science Disease 30

      Pages: 62-65

    • Data Source
      KAKENHI-PROJECT-15590633
  • [Journal Article] C聖肝炎ウイルスによる肝癌発症のメカニズム-PPARαの役割2004

    • Author(s)
      田中 直樹, 青山 俊文
    • Journal Title

      日本臨牀 62

      Pages: 20-25

    • Data Source
      KAKENHI-PROJECT-15590633
  • [Journal Article] In vitro stabilization of nuclear retinoide X receptor alpha in the presence of peroxisome proliferators-activated receptor alpha.2003

    • Author(s)
      Tanaka N, Hora K, Makishima H, Kamijo Y, Kiyosawa K, Gonzalez FJ, Aoyama T.
    • Journal Title

      FEBS Lett 543

      Pages: 120-124

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590633
  • [Journal Article] Functional activation of peroxisome proliferators-activated receptor α(PPAR α) by environmental chemicals in relation to their toxicities.2002

    • Author(s)
      Nakajima T, Ichihara G, Kamijima M, Aoyama T.
    • Journal Title

      Nagoya J 65

      Pages: 85-94

    • NAID

      110000023230

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370121
  • [Journal Article] Identification of functions of peroxisome proliferators-activated receptor a in proximal tubules.2002

    • Author(s)
      Kamijo Y, Hora K, Tanaka N, Usuda N, Kiyosawa K, Nakajima T, Gonzalez FJ, Aoyama T.
    • Journal Title

      J Am Soc Nephrol 13

      Pages: 1692-1702

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370121
  • [Journal Article] Functional activation of peroxisome proliferator-activated recept or a (PPARa) by environmental chemicals in relation to their toxicities2002

    • Author(s)
      Nakajima T, Ichihara G, Kamijima M, Aoyama T
    • Journal Title

      Nagoya J 65

      Pages: 85-94

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370121
  • [Journal Article] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARa-null mice through attenuation of increases in oxidative stress

    • Author(s)
      Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez F J, Aoyama T
    • Journal Title

      J Hepatol

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590301
  • [Presentation] EFFECTS OF HYPERTENSION AND ANTIHYPERTENSIVE TREATMENTS ON SULFATIDE LEVELS IN SERUM AND ITS METABOLISM2019

    • Author(s)
      Y. Kamijo, R. Guo, Y. Yamada, M. Harada, T. Nakajima, K. Hashimoto, T. Kashihara, Y. Mitsuhiko, T. Aoyama
    • Organizer
      国際腎臓学会(WCN 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08204
  • [Presentation] 5/6腎摘慢性腎臓病モデルマウスにおける血清スルファチド低下メカニズムの解明2018

    • Author(s)
      山田洋輔、橋本幸始、上條祐司、中嶌岳郎、青山俊文
    • Organizer
      第61回日本腎臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K08204
  • [Presentation] PPARαがコレステロール過剰摂取による血管内凝固作用を軽減する2018

    • Author(s)
      上條祐司、山田洋輔、山口晃典、園田光佑、山田愛子、藤井一聡、原悠太、増田知恵、藤田識志、小川洋平、橋本幸始、中嶌岳郎、青山俊文
    • Organizer
      第61回日本腎臓学会総会
    • Data Source
      KAKENHI-PROJECT-18K08204
  • [Presentation] イルベサルタンはマウス腎においてペルオキシソーム増殖剤活性化受容体alphaを介した腎保護作用を有する2016

    • Author(s)
      原田真、橋本幸始、山田洋輔、中嶌岳郎、青山俊文、上條祐司
    • Organizer
      第59回日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-06-19
    • Data Source
      KAKENHI-PROJECT-25460329
  • [Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxida tive stress2009

    • Author(s)
      Tanaka N, Okiyama W, Aoyama T
    • Organizer
      19^<th> conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Hong Kong
    • Year and Date
      2009-02-14
    • Data Source
      KAKENHI-PROJECT-19590301
  • 1.  NASU Tamie (10020794)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 4 results
  • 2.  HARA Atsushi (70126697)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 3.  TANAKA Naoki (80419374)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 4.  KAMIJO Yuji (50377636)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 5.  ICHIHARA Gaku (90252238)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  Nakajima Takero (30581011)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  MURAYAMA Ninzo (90020718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KIKKAWA Fumitaka (40224985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAWAI Michiyasu (10234014)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HASHIMOTO Takashi (80009935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FURUTA Shuichi (80126705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MIYAZAWA Shoko (20020745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  USUDA Nobuteru (30135123)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  UEMUBA Keiichi (80012756)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  NAKAYAMA Jun (10221459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FUKUSHIMA Yoshimitsu (70273084)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  OMURA Minoru (50243936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KIYOSAWA Kendo (30020829)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  TANAKA Eiji (50163506)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 20.  YOSHIZAWA Kaname (90220615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NAKAMURA Kozo (20345763)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  吉村 長久 (70211662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  黒岩 さち子 (60313863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  太田 浩一 (70262730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  加納 武夫 (50169596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SASAKI Kazutoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  Gonzalez Frank j
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  TAKAHASHI Shogo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  山田 充彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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