Tanaka Naoki 田中直樹

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TANAKA Naoki 田中直樹

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Researcher Number	80419374
Other IDs	https://orcid.org/0000-0002-3212-3836
Affiliation (Current)	2022: 信州大学, 学術研究院医学系, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 信州大学, 学術研究院医学系, 教授 2015 – 2019: 信州大学, 学術研究院医学系, 准教授 2017: 信州大学, 医学(系)研究科(研究院), 准教授 2010: Shinshu University, 医学(系)研究科(研究院), 助教 2007 – 2009: Shinshu University, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Experimental pathology / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Pathological medical chemistry / General medical chemistry / Basic Section 59040:Nutrition science and health science-related / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 栄養学 / 病理学 / 肝臓病学 / ストレス / 内科 / アルコール / C型肝炎ウイルス / 脂肪肝 / 肝細胞癌 / 非アルコール性脂肪肝炎 … More / 核内受容体 / メタボロミクス / コレステロール毒性 / CD44 / マイクロアレイ解析 / 腸管・肝臓連関 / 疾患モデル動物 / 脂質 / β-catenin / 小胞体ストレス / トランス脂肪酸 / 肝癌 / 腸内細菌 / メタボローム解析 / 機能性食品 … More Except Principal Investigator スルファチド / 酸化ストレス / PPARα / アルコール / レシチン / 肝障害 / 炎症 / NF-kB / NF-κB / エタノール / 肝炎 / PPAR / リアルタイムPCR / 胃粘膜 / 野生型マウス / ケモカイン / 生体分子 / HCV / トランス脂肪酸 / 肝がん / C型肝炎ウイルスコア蛋白 / PPARalpha / デオキシコール酸 / トランス脂肪酸食 / 肝臓非癌部・癌部 / 脂質 / 発癌 / C型肝炎 / 硫酸化糖脂質 / 老化促進モデルマウス / 腎臓病 / 脂肪酸代謝 / autophagy / 不飽和脂肪酸 Less

Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction
- Principal Investigator
  
  上條祐司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shinshu University
The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods
- Principal Investigator
  
  中嶌岳郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shinshu University
食事中トランス脂肪酸による肝発癌促進機構の解明と予防法の開発Principal Investigator
- Principal Investigator
  
  田中直樹
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Shinshu University
Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolismPrincipal Investigator
- Principal Investigator
  
  TANAKA Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids
- Principal Investigator
  
  Nakajima Takero
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Shinshu University
PPARα活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発Principal Investigator
- Principal Investigator
  
  田中直樹
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shinshu University
Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods
- Principal Investigator
  
  AOYAMA Toshifumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Shinshu University
Analysis of pathogenesis of alcoholic liver disease and development of novel therapies using PPARalpha-null micePrincipal Investigator
- Principal Investigator
  
  TANAKA Naoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Shinshu University

All 2019 2017 2016 2009 Other

All Journal Article Presentation

[Journal Article] A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.2019
- Author(s)
  Wang X, Tanaka N, Hu X, Kimura T, Lu Y, Jia F, Sato Y, Nakayama J, Moriya K, Koike K, Aoyama T
- Journal Title
  
  Arch Toxicol.
  
  Volume: in press
- DOI
  10.1007/s00204-019-02440-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08616
[Journal Article] Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene2017
- Author(s)
  Tian Y, Yang Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Lu Y, Moriya K, Koike K, Gonzalez FJ, Aoyama T.
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 33 Pages: 927-936
- DOI
  10.1007/s10719-016-9703-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08264, KAKENHI-PROJECT-16K08616
[Journal Article] Decreased Fatty Acid <i>β</i>-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice2017
- Author(s)
  Nakajima T, Yang Y, Lu Y, Kamijo Y, Yamada Y, Nakamura K, Koyama M, Yamaguchi S, Sugiyama E, Tanaka N, Aoyama T
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 242(3) Issue: 3 Pages: 229-239
- DOI
  10.1620/tjem.242.229
- NAID
  130005808367
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.2016
- Author(s)
  Yang Y, Feng Y, Zhang X, Nakajima T, Tanaka N, Sugiyama E, Kamijo Y, Aoyama T.
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 240 Pages: 113-22
- DOI
  10.1620/tjem.240.113
- NAID
  130005245903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08264
[Journal Article] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARa-null mice through attenuation of increases in oxidative stress
- Author(s)
  Okiyama W, Tanaka N, Nakajima T, Tanaka E, Kiyosawa K, Gonzalez F J, Aoyama T
- Journal Title
  
  J Hepatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590301
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress2009
- Author(s)
  Tanaka N, Okiyama Y, Aoyama T
- Organizer
  19^<th> Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Hong Kong
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19790476
[Presentation] アルコール性肝炎に対するポリエンフォスファチジルコリンの有用性2009
- Author(s)
  田中直樹, 小松通治, 青山俊文
- Organizer
  第12回日本病態栄養学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-01-11
- Data Source
  KAKENHI-PROJECT-19790476
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxida tive stress2009
- Author(s)
  Tanaka N, Okiyama W, Aoyama T
- Organizer
  19^<th> conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Hong Kong
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19590301
[Presentation] Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress2009
- Author(s)
  Tanaka N, Okiyama W, Aoyama T
- Organizer
  19^<th> conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  The People's Republic of China
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-19790476

1. AOYAMA Toshifumi (50231105)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. Nakajima Takero (30581011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. KAMIJO Yuji (50377636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. NAKAMURA Kozo (20345763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 長屋匡信 (00718033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菅野祐幸 (40252663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Gonzalez Frank j

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAHASHI Shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tanaka Naoki 田中 直樹

TANAKA Naoki 田中 直樹

Research Projects

Research Products

Co-Researchers

Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

食事中トランス脂肪酸による肝発癌促進機構の解明と予防法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluating the pathogenesis of non-alcoholic steatohepatitis from the viewpoint of xenobiotic metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PPARα活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogenesis of alcoholic liver disease and development of novel therapies using PPARalpha-null micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-dependent PPARalpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased Fatty Acid <i>β</i>-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.2016

Author(s)

Journal Title

Tanaka Naoki 田中直樹

TANAKA Naoki 田中直樹