mizokami atsushi 溝上敦

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MIZOKAMI Atsushi 溝上敦

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Researcher Number	50248580
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 医学系, 教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 金沢大学, 医学系, 教授 2013 – 2016: 金沢大学, 医学系, 准教授 2008 – 2012: 金沢大学, 附属病院, 講師 2011: 金沢大学, 大学病院, 講師 2004 – 2007: Kanazawa University, Hospital, Lecturer, 医学部附属病院, 講師 2001 – 2004: 金沢大学, 医学部附属病院, 助手 1996 – 1997: 産業医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Urology / Urology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields Except Principal Investigator Urology / Basic Section 56030:Urology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Urology
Keywords	Principal Investigator 前立腺癌 / prostate cancer / COX-2 / VEGF / cDNA microarray / 去勢抵抗性前立腺癌 / lipoxygenase / ホルモン非依存性 / promoter / TPA … More / 去勢抵抗性 / 間葉上皮移行 / 肝間質細胞 / 肝転移 / Taxane系耐性前立腺癌 / taxane系耐性前立腺癌 / クロストーク / タキサン耐性 / 薬剤耐性 / フラボノイド / 抗癌剤耐性 / フラボノイド誘導体 / 癌細胞間作用 / 微小環境 / androgen-dependent / ホルモン依存性 / 抗癌剤抵抗性 / リポキシゲナーゼ / サイクロオキシナーゼ2 / 前立腺 / relapse / androgen dependency / 遺伝子治療 / 再燃 / renal cell carcinoma / プロモーター / 腎癌 / DHEA / アンドロゲン受容体 / 2'-hydroxyflavanone / AR-V7 / 誘導体 / 2’-hydroxyflavanone / デキサメサゾン / CAMKK2 / アンドロゲン感受性 / アンドロゲン … More Except Principal Investigator 前立腺癌 / ケモカイン / 去勢抵抗性前立腺癌 / 間質細胞 / prostate cancer / 微小環境 / NF-κB / 再燃前立腺癌 / アンドロゲン / パクリタキセル耐性 / 免疫チェックポイント阻害薬 / 腎細胞癌 / ジテルペン / 去勢抵抗性 / 腫瘍免疫 / アンドロゲン受容体 / LNCaP / real-time PCR / STS / AZF / Her-2 / 骨転移 / ドセタキセル耐性 / ｱﾝﾄﾞﾛｹﾞﾝ / 共培養 / SOD3 / エストロゲン / 遺伝子治療 / 再燃 / 腫瘍随伴マクロファージ / 抗炎症作用 / FGF / KRAS / ダブルネガティブ去勢抵抗性 / コホート研究 / 枯葉剤 / ベトナム / ステロイドホルモン / 低体重出生児 / 二次性徴 / ダイオキシン / バイオマーカー / TCRレパトア / 免疫チェックポイント / リンパ節転移 / 内臓転移 / micro RNA / 遊走能 / マイクロRNA / コーヒー / タキサン抵抗性 / カバジタキセル耐性 / 耐性 / カバジタキセル / ドセタキセル / CRPC / 制御性T細胞 / 腫瘍随伴性マクロファージ / dominant negative / p65 / IκBa / androgen-dependent / androgen-independent / 分子標的創薬 / 転写制御因子 / アンドロゲン非依存性前立腺癌 / 分子標的薬 / ドミナントネガティブ / デコイ / 再燃メカニズム / ホルモン不応性前立腺癌 / Spermatogenesis / genome / palindrome / male infertility / Y chromosome / 精子形成遺伝子 / 無精子症 / 特発性男性不妊症 / 精子形成障害 / ゲノム / パリンドローム / 男性不妊症 / Y染色体 / tyrosine kinase inhibitor / bisphosphonate / bone metastasis / relapse / 胃転移 / 分子標的治療 / 分子様的治療 / HER-2 / Bisphosphonate / hTERT / チロシンキナーゼ阻害剤 / ビスフォスフォネート / 癌微小環境 / アンドロゲン生合成 / アンドロゲン非依存性前立腺癌細胞 / アンドロゲン感受性前立腺癌細胞 / ｱﾝﾄﾞﾛｹﾞﾝ受容体 / フラボノイド誘導体 / クロストーク / カバジタキセル耐性株 / 腎癌 / 植物フラボノイド / ノスカピン / docetaxel / flavonoids / renal cell cancer / Noscapine / cDNA microarray / フラボノイド / SPARC / テストステロン / 酸性ホスファターゼ / トランスポゾン / アロマターゼ / 内因性レトロウイルス / 前立腺がん / シグナル伝達系 / ERE / AR / 転写活性 / リガンド / ER / SCIDマウス / シグナル伝達 / エストロゲン受容体 / TGFβ / CTEN / トラニラスト / DHEA / ワクチン療法 / 分子シャペロン / 免疫治療 / ORP150 / 膀胱癌 Less

腎癌における腫瘍随伴マクロファージを標的としたコーヒージテルペンの抗腫瘍効果
- Principal Investigator
  
  角野佳史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanazawa University
KRAS活性を介したダブルネガティブ去勢抵抗性前立腺癌進展機構の解明
- Principal Investigator
  
  泉浩二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanazawa University
The mechanism of AR signaling-independent prostate cancerPrincipal Investigator
- Principal Investigator
  
  Mizokami Atsushi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Investigation of predictive factors for efficacy of immune heckpoint inhibitor in renal cell carcinoma
- Principal Investigator
  
  Kadono Yoshifumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanazawa University
Cohort study on herbicide/dioxins and secondary sexual characteristic or low weight infants in Vietnam
- Principal Investigator
  
  城戸照彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kanazawa University
Coffee diterpens inhibit prostate cancer progression
- Principal Investigator
  
  IZUMI Kouji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanazawa University
Androgen receptor signaling-controlled microRNA inhibits prostate cancer metastasis
- Principal Investigator
  
  NOHARA Takahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kanazawa University
Progression of prostate cancer bone metastasis by exosomal micro RNA regulated-chemokine
- Principal Investigator
  
  NARIMOTO Kazutaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  St. Luke's International University
The development of the innovative therapeutic drugs which targete crosstalk in the prostate cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Induction of immune tolerance via CCL20 during inhibition of androgen/AR signaling
- Principal Investigator
  
  IZUMI Kouji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Mechanism of docetaxel and cabazitaxel-resistance in castration-resistant prostate cancer
- Principal Investigator
  
  KADONO Yoshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Elucidation of mechanisms of the prostate cancer progress in consideration of AR Axis / microenvironment and the construction of the innovative treatment strategy
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
The mechanisms of prostate cancer progression in bone metastasis microenvironment through CCL2 signaling
- Principal Investigator
  
  NARIMOTO Kazutaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Prevention of CRPC and application for docetaxel treatment using flavonoidsPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Effect of microenvironment on progression of CRPC and on docetaxel-resistance
- Principal Investigator
  
  KADONO Yoshifumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Solution of the molecular mechanism about proliferation / recurrence of the prostate cancer and the architecture of the comprehensive treatment strategy for he prostate cancer
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Effect of Noscapine and its derivative, EM101, on renal cell cancer and their mechanisms
- Principal Investigator
  
  MIYAGI Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Identification of androgen-response genes related with the proliferation and development of proliferation-related marker in prostate cancerPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Comprehensive elucidation of estrogen receptor mediated signal pathways in hormone refractory prostate cancer
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
ゲノム病としての前立腺がん-内因性レトロウイルスとアンドロゲン調節領域-
- Principal Investigator
  
  KOH Eitetsu (高榮哲)
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Significance of NE-κB activation and therapeutic strategies for targeting its pathway in androgen-independent prostate cancer
- Principal Investigator
  
  KONAKA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Identification of progression-related genes in prostate cancer and application to treatmentPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Basic research of gene targeting and molecular targeting therapy for relapse of prostate cancer
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Effect of cyclooxygenase-2 and lipoxygenase on progression of prostate cancerPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Analysis and detecction of polymorphism of palindrome complex on Y chmmosome in idiopathic male infertility
- Principal Investigator
  
  KOH Eitetsu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
小胞体分子シャペロンORP150を用いた膀胱癌に対する癌免疫治療の実験的検討
- Principal Investigator
  
  NAMIKI Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Kanazawa University
Identification of genes associated with relapse of prostate cancer and gene therapyPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kanazawa university
Analysis of mechanism for VEGF expression in renal cell carcinomaPrincipal Investigator
- Principal Investigator
  
  MIZOKAMI Atsushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Unuversity of Occupational and Environmental Health

[Journal Article] Sarcopenia and Visceral Metastasis at Cabazitaxel Initiation Predict Prognosis in Patients With Castration-resistant Prostate Cancer Receiving Cabazitaxel Chemotherapy.2021
- Author(s)
  Iwamoto H, Kano H, Shimada T, Naito R, Makino T, Kadomoto S, Yaegashi H, Shigehara K, Izumi K, Kadono Y, Mizokami A.
- Journal Title
  
  In Vivo
  
  Volume: 35 Issue: 3 Pages: 1703-1709
- DOI
  10.21873/invivo.12430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09685, KAKENHI-PROJECT-21K16728
[Journal Article] Undesirable Status of Prostate Cancer Cells after Intensive Inhibition of AR Signaling: Post-AR Era of CRPC Treatment.2021
- Author(s)
  Makino T, Izumi K, Mizokami A.
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 4 Pages: 414-414
- DOI
  10.3390/biomedicines9040414
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09685
[Journal Article] Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells2021
- Author(s)
  Makino T, Izumi K, Hiratsuka K, Kano H, Shimada T, Nakano T, Kadomoto S, Naito R, Iwamoto H, Yaegashi H, Shigehara K, Kadono Y, Nakata H, Saito Y, Nakagawa-Goto K, Sakai N, Iwata Y, Wada T, Mizokami A.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 675-675
- DOI
  10.1038/s41598-020-80302-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08426, KAKENHI-PROJECT-19K09685, KAKENHI-PROJECT-20K09574
[Journal Article] Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells.2019
- Author(s)
  Iwamoto H, Izumi K*, Natsagdorj A, Naito R, Makino T, Kadomoto S, Hiratsuka K, Shigehara K, Kadono Y, Narimoto K, Saito Y, Nakagawa-Goto K, Mizokami A.
- Journal Title
  
  Prostate
  
  Volume: 79 Issue: 5 Pages: 468-479
- DOI
  10.1002/pros.23753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11126
[Journal Article] C-C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment.2018
- Author(s)
  Urata S, Izumi K, Hiratsuka K, Maolake A, Natsagdorj A, Shigehara K, Iwamoto H, Kadomoto S, Makino T, Naito R, Kadono Y, Lin WJ, Wufuer G, Narimoto K, Mizokami A
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 724-731
- DOI
  10.1111/cas.13494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11126
[Journal Article] Crosstalk Between Androgen-Sensitive and Androgen-Insensitive Prostate Cancer Cells2018
- Author(s)
  YUTA TAKEZAWA, KOUJI IZUMI, KAZUAKI MACHIOKA, HIROAKI IWAMOTO, RENATO NAITO, TOMOYUKI MAKINO, SUGURU KADOMOTO, ARIUNBOLD NATSAGDORJ, YOSHIFUMI KADONO, EVAN T. KELLER, JIAN ZHANG and ATSUSHI MIZOKAMI
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Pages: 2045-2055
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04325
[Journal Article] Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines2018
- Author(s)
  Kazuaki Machioka, 1Kouji Izumi, 1Yoshifumi Kadono, 1Hiroaki Iwamoto, 1Renato Naito, 1Tomoyuki Makino, 1Suguru Kadomoto, 1Ariunbold Natsagdorj, 2Evan T. Keller, 3Jian Zhang, and 1Atsushi Mizokami
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 16185-16196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04325
[Journal Article] Tumor necrosis factor-α induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation.2018
- Author(s)
  Maolake A, Izumi K, Natsagdorj A, Iwamoto H, Kadomoto S, Makino T, Naito R, Shigehara K, Kadono Y, Hiratsuka K, Wufuer G, Nastiuk KL, Mizokami A.
- Journal Title
  
  Cancer science
  
  Volume: 109 Issue: 5 Pages: 1524-1531
- DOI
  10.1111/cas.13586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11128, KAKENHI-PROJECT-16K10998
[Journal Article] Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.2018
- Author(s)
  Machioka K, Izumi K, Kadono Y, Iwamoto H, Naito R, Makino T, Kadomoto S, Natsagdorj A, Keller ET, Zhang J, Mizokami A
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 22 Pages: 16185-16196
- DOI
  10.18632/oncotarget.24609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04325, KAKENHI-PROJECT-16K10999
[Journal Article] Crosstalk Between Androgen-sensitive and Androgen-insensitive Prostate Cancer Cells.2018
- Author(s)
  Takezawa Y, Izumi K, Machioka K, Iwamoto H, Naito R, Makino T, Kadomoto S, Natsagdorj A, Kadono Y, Keller ET, Zhang J, Mizokami A.
- Journal Title
  
  Anticancer research
  
  Volume: 38 Pages: 2045-2055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04325
[Journal Article] Active Estrogen Synthesis and its Function in Prostate Cancer-derived Stromal Cells2015
- Author(s)
  K. Machioka, A. Mizokami, Y. Yamaguchi, K. Izumi, S. Hayashi and M. Namiki
- Journal Title
  
  Anticancer Res
  
  Volume: 35 Pages: 221-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293350
[Journal Article] SOD3 acts as a tumor suppressor in PC-3 prostate cancer cells via hydrogen peroxide accumulation.2014
- Author(s)
  J. Kim, A. Mizokami, M. Shin, K. Izumi, H. Konaka, Y. Kadono, Y. Kitagawa, E. T. Keller, J. Zhang and M. Namiki
- Journal Title
  
  Anticancer Res
  
  Volume: 34 Pages: 2821-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293350
[Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone2013
- Author(s)
  M. Ofude, A. Mizokami, M. Kumaki, K. Izumi, H. Konaka, Y. Kadono, Y. Kitagawa, M. Shin, J. Zhang, E. T. Keller and M. Namiki
- Journal Title
  
  Anticancer Research
  
  Volume: 10 Pages: 4453-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462472
[Journal Article] Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin beta12013
- Author(s)
  Shin M, Mizokami A, Kim J, Ofude M, Konaka H, Kadono Y, Kitagawa Y, Miwa S, Kumaki M, Keller ET, Namiki M
- Journal Title
  
  Prostate
  
  Volume: 73(11) Issue: 11 Pages: 1159-1170
- DOI
  10.1002/pros.22664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390379, KAKENHI-PROJECT-23791747
[Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone2013
- Author(s)
  Ofude M, Mizokami A, Kumaki M, Izumi K, Konaka H, Kadono Y, Kitagawa Y, Shin M, Zhang J, Keller ET, Namiki M
- Journal Title
  
  Anticancer Res
  
  Volume: 33(10) Pages: 4453-4461
- URL
  http://ar.iiarjournals.org/content/33/10/4453.full.pdf+html
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390379
[Journal Article] Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer2012
- Author(s)
  Takashi Shima, Atsushi Mizokami, Toru Miyagi, Keiichi Kawai, Kouji Izumi, Misako Kumaki, Mitsuo Ofude, Jian Zhang, Evan T. Keller, and Mikio Namiki
- Journal Title
  
  The Prostate
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592037
[Journal Article] Ethinylestradiol improves prostate-specific antigen levels in pretreated castration-resistant prostate cancer patients.2010
- Author(s)
  Izumi K, Kadono Y, Shima T, Konaka H, Mizokami A, Koh E, Namiki M.
- Journal Title
  
  Anticancer Res. 30
  
  Pages: 5201-5205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591852
[Journal Article] CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer.2010
- Author(s)
  Li, Y., Mizokami, A., izumi, K., Narimoto, K., Namiki , M.(他4名)
- Journal Title
  
  Prostate 70
  
  Pages: 48-60
- NAID
  120001828357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390421
[Journal Article] Preliminary results of tranilast treatment for patients with advanced castration-resistant prostate cancer.2010
- Author(s)
  Izumi, K, Mizokami, A.Namiki, M, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 30 Pages: 3077-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390421
[Journal Article] Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA.2009
- Author(s)
  Mizokami, A.Kohl E.Izumi, K.Narimoto, K.Takeda, M.Honma, S.Dai, J.Keller, E.Namiki, M.
- Journal Title
  
  Endocr Relat Cancer 16
  
  Pages: 1139-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390421
[Journal Article] Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA2009
- Author(s)
  溝上敦, 並木幹夫, ら
- Journal Title
  
  Endocrine-Related Cancer 16
  
  Pages: 1139-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390421
[Journal Article] Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor betal-associated osteoblastic changes.2009
- Author(s)
  Izumi, K.Mizokami, A.Li, Y.Q.Narimoto, K.Namiki, M.(他6名)
- Journal Title
  
  Prostate 69
  
  Pages: 1222-1234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390421
[Journal Article] Primary combined androgenbrockade in localized disease and its mechanism.2008
- Author(s)
  Namiki M, Kitagawa Y, Mizokami A, Koh E.
- Journal Title
  
  Best Pract Res Clin Endocrinol Metab. 22
  
  Pages: 303-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659248
[Journal Article] Establishment and characterization of androgen-independent human prostate cancer cell lines, LN-REC4 and LNCaP-SF, from LNCaP2007
- Author(s)
  Yoichi Iwasa, Atsushi Mizokami et al.
- Journal Title
  
  International Journal of Urology 14
  
  Pages: 233-239
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591669
[Journal Article] Establishment and characterization of androgen-independent human prostate cancer cell lines. LN-REC4 and LNCaP-SF, from LNCaP2007
- Author(s)
  Yoichi Iwasa, Atsushi Mizokami et al.
- Journal Title
  
  International journal of Urology (In press)
- Data Source
  KAKENHI-PROJECT-17591669
[Journal Article] Hormonal therapy2007
- Author(s)
  Namiki, M., Ueno, S., Kitagawa, Y., Konaka, H., Mizokami, A., Koh, E., Fukagai, T
- Journal Title
  
  Int J Olin Oncol 12(6)
  
  Pages: 427-32
- NAID
  10020114982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] Hormonal therapy.2007
- Author(s)
  Namiki M, Ueno S, Kitagawa Y, Konaka H, Mizokami A, Koh E, Fukagai T.
- Journal Title
  
  Int J Clin Oncol. 12
  
  Pages: 427-432
- NAID
  10020114982
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591742
[Journal Article] The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor2004
- Author(s)
  Mizokami A, Namiki M, et al.
- Journal Title
  
  Cancer Research 64・1
  
  Pages: 765-771
- Data Source
  KAKENHI-PROJECT-15390488
[Journal Article] Cyclooxygenase-2 promotes prostate cancer progression2002
- Author(s)
  Fujita, H., Koshida, K., Keller, E.T., Takahashi, Y., Yoshimito, T., Namiki, M., Mizokami, A.
- Journal Title
  
  The prostate 53
  
  Pages: 232-240
- Data Source
  KAKENHI-PROJECT-13671640
[Patent] 前立腺癌治療組成物及び前立腺癌治療2011
- Inventor(s)
  溝上敦、並木幹夫
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2011-183183
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-21592037
[Patent] 前立腺癌治療組成物及び前立腺癌治療組成物の有効成分のスクリーニング方法2011
- Inventor(s)
  溝上敦, 並木幹夫
- Industrial Property Rights Holder
  金沢大学
- Industrial Property Number
  2011-183183
- Filing Date
  2011-08-25
- Data Source
  KAKENHI-PROJECT-21592037
[Patent] 様々な細胞でのDHEAからDHTに変換する酵素の活性測定法2008
- Inventor(s)
  溝上敦, 並木幹夫
- Industrial Property Rights Holder
  溝上敦, 並木幹夫
- Filing Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-20390421
[Patent] 様々な細胞でのDHEAからDHTに変換する酵素の活性測定法2008
- Inventor(s)
  溝上敦,並木幹夫
- Industrial Property Rights Holder
  金沢大学
- Filing Date
  2008-07-16
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] ARシグナル抑制によるCCL20-CCR6経路の活性化を介した前立腺癌転移促進機構2022
- Author(s)
  加納洋, 泉浩二, 神島泰樹, 島田貴史, 門本卓, 岩本大旭, 八重樫洋, 溝上敦
- Organizer
  第31回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-21K19558
[Presentation] KRAS活性を介した去勢抵抗性前立腺癌進展機構2022
- Author(s)
  神島泰樹, 泉浩二, 鳥海蓮, 中川竜之介, 青山周平, 加納洋, 島田貴史, 門本卓, 内藤伶奈人, 岩本大旭, 角野佳史, 溝上敦
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K09495
[Presentation] コーヒージテルペンkahweol acetateとcafestolのヒト腎細胞癌細胞に対する増殖・遊走抑制効果2021
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] CCL2-CCR2はアンドロゲン非依存性前立腺癌細胞のカバジタキセル体制に関与する2021
- Author(s)
  加納洋、泉浩二、Natsagdorj Ariunbold、福田理恵、神島泰樹、島田貴史、内藤伶奈人、牧野友幸、門本卓、岩本大旭、八重樫洋、角野佳史、溝上敦
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K19558
[Presentation] コーヒージテルペンkahweol acetateとcafestolのヒト腎細胞癌細胞に対する増殖・遊走抑制効果2021
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-20K09574
[Presentation] コーヒージテルペン酢酸カーウェオールとカフェストールのヒト腎癌細胞における抗腫瘍効果についての検討2021
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第71回日本泌尿器科学会中部総会
- Data Source
  KAKENHI-PROJECT-20K09574
[Presentation] コーヒージテルペンKahweol acetateとcafestolは腎細胞癌の増殖・遊走を抑制する2021
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第30回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-20K09574
[Presentation] 新規アンドロゲン受容体シグナル伝達阻害薬とタキサン系抗癌剤は去勢抵抗性前立腺癌の内臓転移を誘発する2021
- Author(s)
  岩本大旭、泉浩二、内藤伶奈人、牧野友幸、門本卓、八重樫洋、角野佳史、溝上敦
- Organizer
  第30回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19558
[Presentation] 新規アンドロゲン受容体シグナル伝達阻害薬とタキサン系抗癌剤は去勢抵抗性前立腺癌の内臓転移を誘発する2021
- Author(s)
  岩本大旭、泉浩二、内藤伶奈人、牧野友幸、門本卓、八重樫洋、角野佳史、溝上敦
- Organizer
  第30回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] CCL2-CCR2はアンドロゲン非依存性前立腺癌細胞のカバジタキセル体制に関与する2021
- Author(s)
  加納洋、泉浩二、Natsagdorj Ariunbold、福田理恵、神島泰樹、島田貴史、内藤伶奈人、牧野友幸、門本卓、岩本大旭、八重樫洋、角野佳史、溝上敦
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] Anticancer effects of coffee diterpenes kahweol acetate and cafectol on prostate cancer2021
- Author(s)
  Hiroaki Iwamoto, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K19558
[Presentation] コーヒージテルペン酢酸カーウェオールとカフェストールのヒト腎癌細胞における抗腫瘍効果についての検討2021
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第71回日本泌尿器科学会中部総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] コーヒージテルペンであるカーウェオールアセテートtpカフェストールは前立腺癌細胞の増殖と遊走を相乗的に阻害する2020
- Author(s)
  岩本大旭、泉浩二、門本卓、内藤伶奈人、牧野友幸、八重樫洋、飯島将司、川口昌平、野原隆弘、重原一慶、角野佳史、溝上敦
- Organizer
  第108回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] 新規アンドロゲン受容体シグナル伝達阻害薬とタキサン系抗癌剤は去勢抵抗性前立腺癌の内臓転移を誘発する2020
- Author(s)
  岩本大旭、泉浩二、門本卓、八重樫洋、飯島将司、川口昌平、野原隆弘、重原一慶、角野佳史、溝上敦
- Organizer
  第70回日本泌尿器科学会中部総会
- Data Source
  KAKENHI-PROJECT-19K09707
[Presentation] コーヒージテルペンKahweol acetateとcafestolは腎細胞癌の増殖・遊走を抑制する2020
- Author(s)
  牧野友幸、泉浩二、岩本大旭、加納洋、島田貴史、門本卓、内藤伶奈人、八重樫洋、角野佳史、溝上敦
- Organizer
  第108回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] コーヒージテルペンであるkahweol acetateとcafestolは相乗作用で前立腺癌細胞の増殖と遊走を阻害する2019
- Author(s)
  岩本大旭、泉浩二、ナッサグドルジアリウンボルト、門本卓、内藤伶奈人、牧野友幸、角野佳史、溝上敦
- Organizer
  第107回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09685
[Presentation] アンドロゲン感受性前立腺癌細胞と非感受性前立腺癌細胞のクロストーク2016
- Author(s)
  武澤　雄太、溝上　敦、泉　浩二、並木　幹夫
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26293350
[Presentation] Crosstalk of androgen sensitive prostate cancer cells and insensitive prostate cancer cells2016
- Author(s)
  Takezawa Yuta, Mizokami Atsushi, Machioka Kazuaki, Izumi Kouji, Iwamoto Hiroaki, Aerken Maolake, Ariunbold Natsagdorj, and Namiki Mikio
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293350
[Presentation] アンドロゲン感受性前立腺癌細胞と非感受性前立腺癌細胞の協調作用2015
- Author(s)
  溝上　敦
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26293350
[Presentation] Down-regulation of CAMKK2 by androgen deprivation induces castration-resistant prostate cancer2012
- Author(s)
  Takashi Shima, Atsushi Mizokami, Toru Miyagi, Keiichi Kawai, Kouji Izumi, Misako Kumaki, Zhang Jian, Evan T. Keller, and Mikio Namiki.
- Organizer
  AACR Annual Meeting
- Place of Presentation
  McCormick Place in Chicago(USA)
- Year and Date
  2012-04-01
- Data Source
  KAKENHI-PROJECT-21592037
[Presentation] Gene-Sの発現抑制は前立腺癌細胞の増殖を促進し、アンドロゲン高感受性を誘導する2011
- Author(s)
  溝上敦、島崇、熊木美紗子、並木幹夫
- Organizer
  第19回日本ステロイドホルモン学会学術集会
- Place of Presentation
  福岡大学病院,福岡県
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-21592037
[Presentation] Gene-Sの発現抑制は前立腺癌細胞の増殖を促進し、アンドロゲン高感受性を誘導する2011
- Author(s)
  溝上敦
- Organizer
  第19回日本ステロイドホルモン学会学術集会
- Place of Presentation
  福岡大学病院(福岡県)
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-21592037
[Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンと前立腺癌間質細胞の役割2010
- Author(s)
  溝上敦, 熊木美紗子, 島崇, 成本一隆, 小中弘之, 角野佳史, 北川育秀, 高栄哲, 並木幹夫
- Organizer
  第18回日本ステロイドホルモン学会
- Place of Presentation
  愛知県産業労働センター(愛知県)
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-20591852
[Presentation] 再燃前立腺癌に対するトラニラストによる抗腫瘍効果の臨床的検討2010
- Author(s)
  溝上敦、泉浩二、並木幹夫
- Organizer
  第60回日本泌尿器科学会中部総会
- Place of Presentation
  愛知県産業労働センター(名古屋) 招待講演
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 去勢抵抗性前立腺癌患者に対するエチニルエストラジオールの有効性2010
- Author(s)
  角野佳史, 泉浩二, 藤田博, 北川育秀, 小中弘之, 溝上敦, 高栄哲, 並木幹夫
- Organizer
  第26回前立腺シンポジウム
- Place of Presentation
  東京コンファレンスセンター(東京都)
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-20591852
[Presentation] CTEN, A Gene Related with Paclitaxel-resistance and Tumor Progression in Prostate Cancer.2009
- Author(s)
  李友強, 溝上敦, 泉浩二, 成本一隆, 並木幹夫
- Organizer
  Advances in Prostate Cancer Research
- Place of Presentation
  The Westin San Diego Hotel (USA)
- Year and Date
  2009-01-22
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 前立腺癌間質細胞は副腎性アンドロゲンDHEAを変換し、アンドロゲン受容体を活性化する2009
- Author(s)
  溝上敦
- Organizer
  第18回泌尿器科分子・細胞研究会
- Place of Presentation
  鹿児島
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 前立腺癌間質細胞は副腎性アンドロゲンDHEAを変換し、アンドロゲン受容体を活性化する2009
- Author(s)
  溝上敦、高栄哲、小中弘之、角野佳史、成本一隆、泉浩二、島崇、並木幹夫
- Organizer
  第18回泌尿器分子細胞研究会
- Place of Presentation
  鹿児島大学鶴陵会館(鹿児島県)
- Year and Date
  2009-02-14
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンDHEAと前立腺癌間質細胞の役割2009
- Author(s)
  溝上敦、高栄哲、泉浩二、成本一隆、小中弘之、角野佳史、北川育秀、並木幹夫
- Organizer
  第97回日本泌尿器科学会総会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンDHEAと前立腺癌間質細胞の役割2009
- Author(s)
  溝上敦, 並木幹夫, ら
- Organizer
  第97回日本泌尿器科学会総会
- Place of Presentation
  岡山コンベンションセンター (岡山県)
- Year and Date
  2009-04-17
- Data Source
  KAKENHI-PROJECT-20390421
[Presentation] 前立腺癌に対するトラニラストの抗腫瘍効果の検討2008
- Author(s)
  泉浩二、溝上敦、李友強、成本一隆、杉本和宏、北川育秀、角野佳史、小中弘之、高栄哲、並木幹夫
- Organizer
  第24回前立腺シンポジウム
- Place of Presentation
  東京コンファレンスセンター(東京都)
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-20390421

1. IZUMI Kouji (80646787)

# of Collaborated Projects: 13 results

# of Collaborated Products: 30 results
2. NAMIKI Mikio (70155985)

# of Collaborated Projects: 9 results

# of Collaborated Products: 19 results
3. KADONO Yoshifumi (10397218)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
4. KONAKA Hiroyuki (40334768)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
5. KYO Satoru (50272969)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. KASHIDA Kiyoshi (70186667)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. NARIMOTO Kazutaka (50645207)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. 後藤享子 (50180245)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HIGASHI Tatuya (90272963)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KOH Eitetsu (90283134)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. MIWA Sotarou (80507070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. MIYAGI Toru (60467107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. SHIGEHARA Kazuyoshi (20595459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KITAGAWA Yasuhide (00452102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANEKO Shuichi (60185923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NOHARA Takahiro (20733372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 小川智 (90283746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 城戸照彦 (20167373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中川秀昭 (00097437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 八重樫洋 (00835275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 岡本理恵 (50303285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 岩本大旭 (90847245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. IWATA Yasunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

mizokami atsushi 溝上 敦

MIZOKAMI Atsushi 溝上 敦

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The mechanism of AR signaling-independent prostate cancerPrincipal Investigator

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The development of the innovative therapeutic drugs which targete crosstalk in the prostate cancer microenvironmentPrincipal Investigator

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Prevention of CRPC and application for docetaxel treatment using flavonoidsPrincipal Investigator

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mizokami atsushi 溝上敦

MIZOKAMI Atsushi 溝上敦