Shibata Hiroyuki 柴田浩行

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SHIBATA Hiroyuki 柴田浩行

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Researcher Number	50260071
Other IDs
External Links
Affiliation (Current)	2025: 秋田大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 秋田大学, 医学系研究科, 教授 2012 – 2015: 秋田大学, 医学(系)研究科(研究院), 教授 2010 – 2012: 秋田大学, 大学院・医学系研究科, 教授 2009: 秋田大学, 医学部, 教授 2007 – 2008: 東北大学, 加齢医学研究所, 准教授 … More 2003 – 2006: Tohoku University, Hospital, Lecturer, 病院・講師 2005: TOHOKU UNIVERSITY, HOSPITAL, LECTURER, 病院, 講師 2004: 東北大学, 大学病院, 講師 2003: 東北大学, 医学部附属病院, 講師 1996 – 2002: 東北大学, 加齢医学研究所, 助手 1996: 財団法人癌研究會, 癌研究所細胞生物部, 研究員 1995 – 1996: 財団法人癌研究會, 癌研究所・細胞生物部, 研究員 1994: (財)癌研究所, 細胞生物部, 研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 59040:Nutrition science and health science-related / Gastroenterology / Tumor therapeutics / Clinical oncology Except Principal Investigator Gastroenterology / Biological Sciences / Human genetics / Molecular biology / Neuroscience in general
Keywords	Principal Investigator クルクミン / erbb2 / c-Myc / Ki-Ras / 大腸癌 / β-Catenin / APC遺伝子 / 発がん予防 / がん免疫 / 食品 … More / ATP産生 / ミトコンドリア / クルクミンアナログ / 乳酸 / 2-deoxy-d-glucose / GO-Y022 / 機能性食品 / 腫瘍免疫 / 制御性T細胞 / phytochemical / chemoprevention / Cyclin-D1 / beta-catenin / 化学発癌予防 / 家族性大腸腺腫症 / cyclin D1 / Ki-ras / β-catenin / ErbB2 / Cyclin D1 / beta-Catenin / APC gene / APC / Wntシグナル / 腫瘍血管新生 / 血管内皮細胞 / 悪性リンパ腫 / 大腸がん / マイクロRNA（miRNA） / メッセンジャーRNA（mRNA） / microRNA / KSRP / miRNA / mRNA / 放射線防護作用 / 抗がん剤 / 浸潤抑制 / 血管新生阻害 / ミエローマ / がん治療 / マルチターゲット / 発がん予防活性 / 転移抑制活性 / 腫瘍血管阻害活性 / 誘導体 / がん幹細胞 / NF-κBシグナル伝達阻害 / 抗腫瘍活性 / 制御遺伝子 … More Except Principal Investigator hMLH1 / p53 / ジーンターゲティング / MLH1 / Cre組換え酵素 / second-site suppressor / super p53 / APC / ミスマッチ修復 / 機能診断 / missense mutation / MYH / BRCA1 / ミスセンス変異 / 機能解析 / がん抑制遺伝子 / アデノウイルスベクター / コンディショナル・ノックアウト / 大腸癌 / ケラチン14遺伝子 / APC遺伝子 / LoxP配列 / gastrointestinal cancer / 消化器癌 / comprehensive mutation library / 診断 / 機能 / DNAミスマッチ修復 / 網羅的変異ライブラリー / stop codon assay / colorectal tumor / mismatch repair system / carcinogen / tumor suppressor gene / SC assay / Yeast / ストップコドンアッセイ法 / MSH2 / ミスマッチ修復遺伝子 / functional analysis / Saccharomyces cerevisiae / misnatch repair / 遺伝子機能 / 遺伝子診断 / 遺伝性大腸癌 / 出芽酵母 / olfactory marker protein / Purkinje cell specific protein 2 / keratin 14 / transgenic mouse / recombinant adenovirus / loxP sequences / Cre recombinase / gene targeting / PCP2遺伝子 / コンディショナルジーンターゲティング / L7プロモーター / L7遺伝子 / PO蛋白遺伝子 / Cre遺伝子 / OMPプロモーター / PCP2プロモーター / K14プロモーター / 組換えアデノウイルス / loxP配列 / トランスジェニック・マウス / ジーンターゲッティング / 変異 / TP53 / 腫瘍関連遺伝子 / がん関連遺伝子 / BRCA2 / PTEN / 遺伝子変異 / p53遺伝子 / MLH1遺伝子 / VHL遺伝子 / モデルマウス / 膵癌 / βカテニン遺伝子 / ノックアウト・マウス / WNTシグナル / βカテニン / コンディショナル・ジーンターゲティング / 胎仔性肝造血 / PEBP2β遺伝子 / AML1遺伝子 / PEBP2αB遺伝子 / ヒト白血病 / オキシトシン / バゾプレッシン / 大細胞性ニューロン / ジーンターゲティング法 / POU転写因子 / デスモプレッシン / 視床下部ニューロン / Brn6欠損マウス / Brn5欠損マウス / POU転写調節因子群 Less

Cancer chemoprevention by using diarylpentanoid analog of curcumin as a functional foodPrincipal Investigator
- Principal Investigator
  
  Shibata Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Akita University
Pharmacological potential of curcumin analog targeting KSRP, a regulator of miRNAPrincipal Investigator
- Principal Investigator
  
  Shibata Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Akita University
Development of a new cancer chemotherapy by using curcumin analogsPrincipal Investigator
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Akita University
Development of functional assays for tumor-related genes
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Development of a nobel strategy for chemoprevention of colorectal carcinogenesis by using newly synthesized organic compounds derived from natural dietary constituentsPrincipal Investigator
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  TOHOKU UNIVERSITY
Development of p53-associated molecular devices for diagnosis and treatment of gastrointestinal cancer
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
大腸癌発がんをコントロールする新しい標的分子の同定と発がん予防・治療薬開発Principal Investigator
- Principal Investigator
  
  柴田浩行
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
がん関連遺伝子変異の検出および機能評価法の開発
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Establishment of a new strategy for colorectal cancer gene therapy by controlling Wnt-signal moleculesPrincipal Investigator
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Functional mapping of missens mutations in hMLH1 gene
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
Inactivation model of human Adenomatous Polyposis Coli gene by using budding yeast in vivo.
- Principal Investigator
  
  KANAMARU Ryonosuke
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
ジーンターゲティングによるPEBP遺伝子ファミリーの機能の解析
- Principal Investigator
  
  美野輪治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
ジーンターゲティングによるヒト発癌機構の解析
- Principal Investigator
  
  野田哲生
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
  Japanese Foundation For Cancer Research
Joint study on the DNA mismatch repair system : Functional analysis of the DNA mismatch repair genes using Saccharomyces cerevisiae.
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
マウス神経系初期発生におけるPOU転写調節因子の役割の解析
- Principal Investigator
  
  野田哲生
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
Establishment of novel conditional gene targeting methods using Cre-loxP system
- Principal Investigator
  
  NODA Tetsuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tohoku University
  Japanese Foundation For Cancer Research
マウス神経系初期発生におけるPOU転写調節因子の役割の解析
- Principal Investigator
  
  NODA Tetsuo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research

[Book] Curcumin: Biosynthesis, Medicinal Uses and Health Benefits, Nova Science Publishers (NY, U.S.A.)2012
- Author(s)
  Shibata H, Iwabuchi Y
- Publisher
  Challenges in Establishing Potent Cancer Chemotherapy using Newly Synthesized 1,5-Diaryl-3-Oxo-1,4-Pentadiene Analogs of Curcumin
- Data Source
  KAKENHI-PROJECT-22501041
[Book] Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
- Author(s)
  Shibata H
- Total Pages
  266
- Publisher
  Nova Science Publishers (NY, U.S.A.)
- Data Source
  KAKENHI-PROJECT-22501041
[Book] Challenges in Establishing Potent Cancer Chemotherapy using Newly Synthesized 1,5-Diaryl-3-Oxo-1,4-Pentadiene Analogs of Curcumin2012
- Author(s)
  H.Shibata, Y Iwabuchi
- Total Pages
  20
- Publisher
  Nova Science Publishers(in press)
- Data Source
  KAKENHI-PROJECT-22501041
[Book] EBMがん化学療法・分子標的治療法2011-20122010
- Author(s)
  柴田浩行(分担執筆)
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22501041
[Book] 消化器がん治療最前線一秋田大学医学部の挑戦「秋田県消化器がんフォーラム」2010
- Author(s)
  大西洋英、柴田浩行、山本雄造
- Publisher
  秋田魁新報社
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Pyrolyzed deketene curcumin controls regulatory T cell generation and gastric cancer metabolism cooperate with 2-deoxy-d-glucose2023
- Author(s)
  MaruYama Takashi、Miyazaki Hirofumi、Lim Yun-Ji、Gu Jian、Ishikawa Masaki、Yoshida Taichi、Chen WanJun、Owada Yuji、Shibata Hiroyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1049713-1049713
- DOI
  10.3389/fimmu.2023.1049713
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11609, KAKENHI-PROJECT-20KK0225, KAKENHI-PROJECT-20K11643, KAKENHI-PROJECT-23K24783, KAKENHI-PROJECT-22K19724
[Journal Article] TGF-β and Cancer Immunotherapy2022
- Author(s)
  MaruYama Takashi、Chen WanJun、Shibata Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 2 Pages: 155-161
- DOI
  10.1248/bpb.b21-00966
- NAID
  130008150256
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-02-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11643
[Journal Article] The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells2021
- Author(s)
  Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
- Journal Title
  
  Frontiers in immunology
  
  Volume: 12 Pages: 687669-687669
- DOI
  10.3389/fimmu.2021.687669
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07541, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K11643
[Journal Article] Curcumin analog GO‐Y030 boosts the efficacy of anti‐PD‐1 cancer immunotherapy2021
- Author(s)
  MaruYama Takashi、Kobayashi Shuhei、Shibata Hiroyuki、Chen WanJun、Owada Yuji
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4844-4852
- DOI
  10.1111/cas.15136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11643
[Journal Article] クルクミン誘導体による胃がん予防研究2015
- Author(s)
  柴田浩行
- Journal Title
  
  Functional food: 機能性食品の基礎から臨床へ
  
  Volume: 9 Pages: 18-22
- Data Source
  KAKENHI-PROJECT-25430147
[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis2011
- Author(s)
  Sato, A., Kudo, C., Yamakoshi, H., Uehara, Y., Ohor,i H., Ishioka, C., Iwabuchi, Y. Shibata H.
- Journal Title
  
  Cancer Science
  
  Volume: 102(5) Pages: 1045-1051
- NAID
  10029293736
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents for multiple myeloma with enhanced abilities2011
- Author(s)
  Kudo C, Yamakoshi H, Sato A, Ohori H, Ishioka C, Iwabuchi Y, Shibata H.
- Journal Title
  
  Anticancer Research
  
  Volume: 31(11) Pages: 3719-3726
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Curcumin analog G0-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis2011
- Author(s)
  H.Shibata, Y Iwabuchi, et al.
- Journal Title
  
  Cancer science
  
  Volume: 102 Pages: 1045-1051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Targeting colon cancer stem cells using a new curcumin analogue2011
- Author(s)
  Lin L, Liu Y, Li H, Li P-K, Shibata H, Iwabuchi Y, Lin J.
- Journal Title
  
  GO-Y030. Br J Cancer
  
  Volume: 105 Pages: 212-220
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKB that suppresses NF-KB signaling and induces apoptosis.2011
- Author(s)
  Shibata H, Iwabuchi Y, Uehara Y, Ohori H, et al
- Journal Title
  
  Cancer Science
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo2011
- Author(s)
  H.Shibata, Y Iwabuchi, et al.
- Journal Title
  
  BMC Pharmacology
  
  Volume: 11 Issue: 1
- DOI
  10.1186/1471-2210-11-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Targeting colon cancer stem cells using a new curcumin analogue, G0-Y0302011
- Author(s)
  H.Shibata, Y Iwabuchi, et al.
- Journal Title
  
  Br J Cancer
  
  Volume: 105 Pages: 212-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo2011
- Author(s)
  Kudo C, Yamakoshi H, Sato A, Nanjo H, Ohori H, Ishioka C, Iwabuchi Y, Shibata H.
- Journal Title
  
  BMC Pharmacology
  
  Volume: 28
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Novel curcumin analogs, G0-Y030 and G0-Y078, are multi-targeted agents for multiple myeloma with enhanced abilities2011
- Author(s)
  H.Shibata, Y Iwabuchi, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 31 Pages: 3719-3726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Phase II study of FOLFOX4 with "wait and go" strategy as first-line treatment for metastatic colorectal cancer2011
- Author(s)
  Shibata h, et al
- Journal Title
  
  Cancer Chemother Pharmacol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue.2010
- Author(s)
  Shibata H, Iwabuchi Y, Ohori H, et al
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 1 Pages: 273-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue2010
- Author(s)
  Yamakoshi, H, Kanoh, N, Kudo, C, Sato, A, Ueda, K, Muroi, M, Kon, S, Satake, M, Ohori, O, Ishioka, C, Oshima, Y, Osada, H, Chiba, N, Shibata H, Iwabuchi, Y.
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 1(6) Pages: 273-276
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009
- Author(s)
  Shibata, H., Yamakoshi, H., Sato, A., Ohori, H., Kakudo, Y., Kudo, C., Takahashi, Y., Watanabe, M., Takano, H., Ishioka, C., Noda, T., Iwabuchi, Y
- Journal Title
  
  Cancer Sci 100
  
  Pages: 956-60
- NAID
  10025146044
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009
- Author(s)
  Shibata H, et al.
- Journal Title
  
  Cancer Sci 100
  
  Pages: 956-960
- NAID
  10025146044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Prediction of breast cancer prognosis by gene expression profile of TP53 status2008
- Author(s)
  Takahashi, S., Moriya, T., Ishida, T., Shibata, H., Sasano, H., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci 99
  
  Pages: 324-32
- NAID
  10024002457
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Alpha-catenin is essential in intestinal adenoma formation2007
- Author(s)
  Shibata, H., Takano, H., Ito, M., Shioya, H., Hirota, M., Matsumoto, H., Kakudo, Y., Ishioka, C., Akiyama, T., Kanegae, Y., Saito, I., Noda, T
- Journal Title
  
  Proc Natl Acad Sci U S A 104
  
  Pages: 18199-204
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Alpha-catenin is essential in intestinal adenoma formation.2007
- Author(s)
  Shibata, H., et. al.
- Journal Title
  
  Proc Natl Acad Sci U S A 104
  
  Pages: 18199-18204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] The screening of the second-site suppressor mutations of the common p53 mutants2007
- Author(s)
  Otsuka, K., Kato, S., Kakudo, Y., Mashiko, S., Shibata, H., Ishioka, C
- Journal Title
  
  Int J Cancer 121
  
  Pages: 559-66
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer2006
- Author(s)
  Ohori, H., Yamakoshi, H., Tomizawa, M., Shibuya, M., Kakudo, Y., Takahashi, A., Takahashi, S., Kato, S., Suzuki, T., Ishioka, C., Iwabuchi, Y., Shibata, H
- Journal Title
  
  Mol Cancer Ther 2006 5
  
  Pages: 2563-2571
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s2005
- Author(s)
  Kakudo, Y., Shibata, H., Otsuka, K., Kato, S., Ishioka, C
- Journal Title
  
  Cancer Res 65
  
  Pages: 2108-14
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] A Phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients
- Author(s)
  Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: (in press)
- NAID
  120005477228
- Data Source
  KAKENHI-PROJECT-22501041
[Patent] BIS(ARYLMETHYLIDENE9ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF KI-RAS, ERBB2, C-MYC AND CYCLINE D1,β-CATENIN-DEGRADATING AGENT, P53 EXPRESSION ENHANCER2012
- Inventor(s)
  Hiroyuki Shibata, Yoshiharu Iwabuchi, Hisatsugu Ohori, Hiroyuki Yamakoshi, Yuichi Kakudo
- Industrial Property Rights Holder
  National University Corporation Tohoku University
- Filing Date
  2012-05-15
- Overseas
- Data Source
  KAKENHI-PROJECT-22501041
[Patent] ビス(アリールメチリデン)アセトン化合物、抗癌剤、発癌予防剤、Ki-Ras、ErbB2、c-Myc及びCyclinD1の発現抑制剤、β-カテニン分解剤並びにp53の発現増強剤2012
- Inventor(s)
  柴田浩行,岩渕好治,大堀久詔,山越博幸,角道祐一
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2012-08-03
- Overseas
- Data Source
  KAKENHI-PROJECT-22501041
[Patent] ビス(アリールメチリデン)アセトン化合物、抗癌剤、発癌予防剤、Ki-Ras、ErbB2、c-Myc及びCyclinD1の発現抑制剤、β-カテニン分解剤並びにp53の発現増強剤2007
- Inventor(s)
  岩淵好治、柴田浩行
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2007-01-04
- Data Source
  KAKENHI-PROJECT-17015002
[Patent] 化合物、抗癌剤、発癌予防財、β-Catenin分解剤2005
- Inventor(s)
  柴田浩行, 岩渕好治, 大堀久詔, 山越博幸, 角道祐一
- Industrial Property Rights Holder
  柴田浩行, 岩渕好治, 大堀久詔, 山越博幸, 角道祐一
- Industrial Property Number
  2005-187394
- Filing Date
  2005-06-27
- Data Source
  KAKENHI-PROJECT-16590571
[Patent] 特許権2005
- Inventor(s)
  柴田浩行, 岩渕好治, 大堀久詔, 山越博幸, 角道祐一
- Industrial Property Rights Holder
  柴田浩行, 岩渕好治, 大堀久詔, 山越博幸, 角道祐一
- Industrial Property Number
  2005-187394
- Filing Date
  2005-06-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590571
[Presentation] 血管新生阻害剤スニチニブやソラフェニブ耐性の打破を目指した新規化合物の開発2016
- Author(s)
  島津和弘、福田耕二、吉田泰一、井上正広、柴田浩行
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府国際コンベンションセンター
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-25430147
[Presentation] 新たな血管新生阻害薬としてのクルクミンアナログの開発2014
- Author(s)
  柴田浩行
- Organizer
  ＢＩＯ　ＴＥＣＨ２０１４　アカデミックフォーラム
- Place of Presentation
  東京ビックサイト
- Year and Date
  2014-05-14
- Data Source
  KAKENHI-PROJECT-25430147
[Presentation] Development of a treatment for cutaneous T cell lymphoma by newly synthesized curcumin analog.2013
- Author(s)
  小峰啓吾, 大塚和令, 柴田浩行
- Organizer
  日本臨床腫瘍学会
- Place of Presentation
  仙台国際センター，　宮城県仙台市
- Data Source
  KAKENHI-PROJECT-25430147
[Presentation] Phase I study of nanoparticle curcumin, a potential anti-cancer agents with improved bioavailability, for patients with cancer who failed standard chemotherapy2012
- Author(s)
  Kanai, M., Imaizumi, A., Otsuka, Y., Matsumoto, S., Chiba, T., Nishihira, J., Shibata, H.
- Organizer
  GAP Annual Conference
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体による大腸がん幹細胞増殖抑制効果2012
- Author(s)
  柴田浩行, 岩渕好治, 大塚和令, 今井源
- Organizer
  第71回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン類縁体の血管新生阻害効果の可能性2012
- Author(s)
  杉山俊輔, 角道祐一, 岩渕好治, 石岡千加史, 柴田浩行
- Organizer
  第16回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] クルクミンアナログ(第2弾)抗がん幹細胞活性と抗トリオパノソーマ活性2012
- Author(s)
  柴田浩行
- Organizer
  第11回国際バイオEXPO バイオアカデミックフォーラム～大学・国公立研究所による研究成果発表フォーラム～
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体による大腸がん幹細胞増殖抑制効果2012
- Author(s)
  柴田浩行
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] クルクミンアナログ（第２弾）抗がん幹細胞活性と抗トリオパノソーマ活性2012
- Author(s)
  柴田浩行
- Organizer
  BIOtech2012 第11回国際バイオテクノロジー展
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] ゲムシタビンに抵抗性となった膵癌・胆道癌患者に対するナノ化クルクミン療法の第I相臨床試験2012
- Author(s)
  金井雅史, 森由希子, 西村貴文, 松本繁巳, 柳原一弘, 千葉勉, 波多野悦朗, 川口義弥, 児玉裕三, 西平順, 大塚和令, 柴田浩行
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン類縁体による抗腫瘍効果の増強とそのメカニズムの検討2011
- Author(s)
  工藤千枝子, 山越博幸, 大堀久詔, 佐藤温子, 石岡千加史, 岩渕好治, 柴田浩行
- Organizer
  第135回東北大学加齢医学研究所集談会
- Place of Presentation
  仙台市
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体によるがん薬物療法の開発2011
- Author(s)
  柴田浩行
- Organizer
  第10回国際バイオEXPO バイオアカデミックフォーラム
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体によるがん薬物療法の開発2011
- Author(s)
  柴田浩行
- Organizer
  第10回国際バイオEXPO バイオアカデミックフォーラム～大学・国公立研究所による研究成果発表フォーラム～
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体の血管新生阻害活性2011
- Author(s)
  柴田浩行,栗山正, 大塚和令, 岩渕好治, 田中正光
- Organizer
  第70回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン誘導体の血管新生阻害活性2011
- Author(s)
  柴田浩行
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MUM1 function2010
- Author(s)
  Kudo, C., Yamakoshi, H., Sato, A., Ohori, H., Ishioka, C., Iwabuchi, Y., Shibata, H.
- Organizer
  第69回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 医学生に対する悪い知らせのコミュニケーション・スキルの教育とその効果に関する検証2010
- Author(s)
  廣川誠, 丸山起誉幸, 片寄喜久, 佐藤圭子, 豊島至, 柴田浩行
- Organizer
  第15回日本緩和医療学会学術大会
- Place of Presentation
  東京都
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 2D-DIGEを用いたプロテオーム解析によるクルクミンの標的分子同定2010
- Author(s)
  近藤久恵, 室井誠, 山越博幸, 叶直樹, 柴田浩行, 岩渕好治, 長田裕之
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 秋田大学病院食道癌Cancer Boardの現状と課題2010
- Author(s)
  本山悟, 丸山起誉幸, 宇佐美修悦, 大西洋英, 神万里夫, 眞嶋浩聡, 松橋保, 安倍明, 石山公一, 古賀誠, 柴田浩行, 大塚和令, 比内雄大, 小川純一
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 秋田大学医学部における臨床腫瘍学教育への取り組み2010
- Author(s)
  柴田浩行, 大塚和令
- Organizer
  第107回日本内科学会総会・講演会
- Place of Presentation
  東京都
- Year and Date
  2010-04-10
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 個別症例における大腸癌原発巣/転移巣別のEGFRシグナル伝達系遺伝子変異の解析2010
- Author(s)
  大塚和令, 南條博, 宮澤秀彰, 打波宇, 吉岡政人, 渡辺剛, 阿部ゆき, 山本雄造, 柴田浩行
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 2D-DIGEを用いたプロテオーム解析によるクルクミンの標的分子同定2010
- Author(s)
  近藤久恵, 室井誠, 山越博幸, 叶直樹, 柴田浩行, 岩渕好治, 長田裕之
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MLTM l function2010
- Author(s)
  Ohori H, Iwabuchi Y, Shibata h, et al
- Organizer
  69^(th) annual meeting of the Japanese Cancer Association
- Place of Presentation
  Osaka, Japan
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] Two cases of breast cancer responding to trastuzumab monotherapy.. Asia Pacific Medical Education Initiative2007
- Author(s)
  Chiba, N., Yoshioka, T., Takahashi, S., Shibata, H., Kato, S., Shimodaira, H., Otsuka, K., Kakudo, Y., Takahashi, M., Yasuda, K., Sakamoto, Y., Ishioka, C
- Organizer
  3rd Asia Pacific Workshop, Molecular targeted Therapy of Cancer
- Place of Presentation
  Shanghai China
- Year and Date
  2007-03-10
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Evaluation of prognostic significance of TP53 expression signature in breast cancer2006
- Author(s)
  Ishioka, C., Shibata, H., Takahashi, S
- Organizer
  The 11th International Congress of Metastasis Research Society Jointed with the 15th Annual Meetng of Japanese Association for Metastasis Research (Plenary Sessions)
- Place of Presentation
  Tokushima Japan
- Year and Date
  2006-09-06
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Analysis of relationship between p53-dependent transcriptional activity and its ability to induce apoptosis2005
- Author(s)
  Kakudo, Y., Shibata, H., Otsuka, K., Kato, S., Ishioka, C
- Organizer
  The 96th American Association for Cancer Research Annual Meeting
- Place of Presentation
  Anaheim U.S. A(Poster Session)
- Year and Date
  2005-04-19
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 新規クルクミンアナログによる皮膚Ｔ細胞性リンパ腫の薬物療法の開発
- Author(s)
  小峰啓吾，　岩渕好治，　大塚和令，　柴田浩行
- Organizer
  日本がん分子標的治療学会
- Place of Presentation
  国立京都国際会館，　京都府京都市
- Data Source
  KAKENHI-PROJECT-25430147

1. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
2. NODA Tetsuo (10183550)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KATO Shunsuke (40312657)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. IWABUCHI Yoshiharu (20211766)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
5. KANAMARU Ryunosuke (70152783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. CHIBA Natuko (50361192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SAKAYORI Masato (20344666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUZUKI Takao (90292276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KATO Shunsuke (60333887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 高野洋志 (00241555)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 芝清隆 (40196415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SHIMODAIRA Hideki (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. UEHARA Yoshihiko (30223499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. OHORI Hisatsugu (30431555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. 美野輪治 (00181967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FRIEND Stephen H

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KOLODNER Richard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中司寛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shibata Hiroyuki 柴田 浩行

SHIBATA Hiroyuki 柴田 浩行

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Cancer chemoprevention by using diarylpentanoid analog of curcumin as a functional foodPrincipal Investigator

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Pharmacological potential of curcumin analog targeting KSRP, a regulator of miRNAPrincipal Investigator

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Development of a new cancer chemotherapy by using curcumin analogsPrincipal Investigator

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Development of a nobel strategy for chemoprevention of colorectal carcinogenesis by using newly synthesized organic compounds derived from natural dietary constituentsPrincipal Investigator

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大腸癌発がんをコントロールする新しい標的分子の同定と発がん予防・治療薬開発Principal Investigator

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Establishment of a new strategy for colorectal cancer gene therapy by controlling Wnt-signal moleculesPrincipal Investigator

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Shibata Hiroyuki 柴田浩行

SHIBATA Hiroyuki 柴田浩行