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Kodama Eiichi  児玉 栄一

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KODAMA Eiichi  児玉 栄一

児玉 栄一  コダマ エイイチ

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Researcher Number 50271151
Other IDs
Affiliation (Current) 2019: 東北大学, 災害科学国際研究所, 教授
Affiliation (based on the past Project Information) *help 2016 – 2019: 東北大学, 災害科学国際研究所, 教授
2012 – 2015: 東北大学, 医学(系)研究科(研究院), 講師
2013: 東北大学, 大学院医学系研究科, 講師
2012: 東北大学, 東北メディカル・メガバンク機構, 講師
2009 – 2011: Tohoku University, 病院, 助教
2003 – 2006: 京都大学, ウイルス研究所, 助手
2000 – 2001: 京都大学, ウイルス研究所, 助手
Review Section/Research Field
Principal Investigator
Biological Sciences / 膠原病・アレルギー・感染症内科学 / Applied pharmacology / Infectious disease medicine / 内科学一般 / Basic Section 54030:Infectious disease medicine-related
Except Principal Investigator
Hematology / Applied pharmacology / Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords
Principal Investigator
HIV / 薬剤耐性 / 逆転写酵素 / ヒト免疫不全症ウイルス / ウイルス / 核酸 / 治療 / ペプチド / 耐性 / HIV … More / 抗ウイルス剤 / Rev / 感染症 / 薬学 / 化学合成 / 天然物 / 抗HIV剤 / メカニズム / 複製ステップ / 融合 / 阻害剤 / gp41 / 細胞融合 / 多剤耐性 / 臨床分離株 / 免疫淘汰 / スクリーニング / アクセサリータンパク / 薬物相互作用 / 核酸誘導体 / human immunodeficiency virus / anti-viral agent / peptide / resistance … More
Except Principal Investigator
ヘルペスウイルス / リン酸化 / 抗ウイルス剤 / DNAメチル化 / デングウイルス / デング熱 / デング出血熱 / ガレクチンー9 / オステオポンチン / バイオマーカー / ガレクチン / プロモーター / ウイルス / HIV / 薬剤耐性 / 逆転写酵素 / 多剤耐性 / HIV / エクソソーム / 細胞分泌小胞 / 細胞治療 / 細胞内包ゲル Less
  • Research Projects

    (14 results)
  • Research Products

    (116 results)
  • Co-Researchers

    (33 People)
  •  ストレス応答生合成と化学修飾を融合した多様性天然物による難治性疾患治療薬の開発Principal InvestigatorOngoing

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Tohoku University
  •  細胞治療を指向した機能性エクソソーム分泌細胞内包ゲルの開発Ongoing

    • Principal Investigator
      中瀬 生彦
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka Prefecture University
  •  休眠遺伝子の覚醒で産生される活性天然物をシーズとする難治性疾患治療薬の網羅的開発Principal InvestigatorOngoing

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Tohoku University
  •  Development of antiviral agents targeting ATP-mediated excisionPrincipal Investigator

    • Principal Investigator
      Kodama Eiichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University
  •  Development of anti-HIV agents that exert synergism with host immune pressurePrincipal Investigator

    • Principal Investigator
      KODAMA Eiichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      Tohoku University
  •  Clinical Utilities of new biomarker for dengue virus infection

    • Principal Investigator
      HATTORI Toshio
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      Tohoku University
  •  Mechanism of resistance to translocation defective reverse transcriptase inhibitors

    • Principal Investigator
      ASHINO Yugo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University
  •  Effect of a novel resistance associated mutation, N348I, which has been identified in Japanese HIV-1 infected patients, on the reverse transcriptase activity.Principal Investigator

    • Principal Investigator
      KODAMA Eiichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University
  •  Establishment of Rev based anti-HIV therapy.Principal Investigator

    • Principal Investigator
      KODAMA Eiichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kyoto University
  •  ヘルペスウイルスを標的とした新規治療薬開発による難治性腫瘍克服

    • Principal Investigator
      松岡 雅雄
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Kyoto University
  •  ヒト免疫不全症ウイルス・細胞融合機構の解明と治療への応用Principal Investigator

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kyoto University
  •  新規HIV複製ステップの同定及びその阻害剤開発への応用Principal Investigator

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  新規HIV複製ステップの同定及びその阻害剤開発への応用Principal Investigator

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  薬剤耐性HIVに著効を示す新規核酸誘導体の開発Principal Investigator

    • Principal Investigator
      児玉 栄一
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      内科学一般
    • Research Institution
      Kyoto University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] A Cinnamon-Derived Procyanidin.Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation2016

    • Author(s)
      Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN, Clayette P, Lortat-Jacob H.
    • Journal Title

      PLoS One.

      Volume: 2

    • DOI
      10.1371/journal.pone.0165386
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05346
  • [Journal Article] A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo2016

    • Author(s)
      Watanabe M, Hashimoto K, Abe Y, Kodama EN, Nabika R, Oishi S, Ohara S, Sato M,Kawasaki Y, Fujii N, Hosoya M.
    • Journal Title

      PLOS ONE

      Volume: 11

    • DOI
      10.1371/journal.pone.0162823
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05346, KAKENHI-PROJECT-15H04654
  • [Journal Article] Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).2016

    • Author(s)
      Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 113 Pages: 9274-9

    • DOI
      10.1073/pnas.1605223113
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05346, KAKENHI-PROJECT-26293239, KAKENHI-PROJECT-16K15520
  • [Journal Article] Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components2015

    • Author(s)
      Tetsuro Hisayoshi, Mayu Shinomura, Kanta Yokokawa, Ikumi Kuze, Atsushi Konishi, Kumi Kawaji, Eiichi N. Kodama, Keishi Hata, Saori Takahashi, Satoru Nirasawa, Kiyoshi Yasukawa.
    • Journal Title

      Journal of Natural Medicines

      Volume: in press Pages: 432-440

    • DOI
      10.1007/s11418-015-0885-9
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-25670255
  • [Journal Article] Synthesis of a Vpr-Binding Derivative forUse as a Novel HIV-1 Inhibitor.2015

    • Author(s)
      Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M, Aida Y
    • Journal Title

      PLoS One

      Volume: 10

    • DOI
      10.1371/journal.pone.0145573
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-25670255
  • [Journal Article] Anti-HIV-1 activitydetermined byb-galactosidase activityin the multinuclear activation ofan indicator assay is comparable with that by a conventional focus counting method.2015

    • Author(s)
      Fusako Miyamoto, Kumi Kawaji, Shinya Oishi, Nobutaka Fujii, Mitsuo Kaku, and Eiichi N.Kodama.
    • Journal Title

      Antiviral Chemistry and Chemotherapy

      Volume: 24(2) Pages: 77-82

    • DOI
      10.1177/2040206615614164
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25670255
  • [Journal Article] Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides2015

    • Author(s)
      T. Asai*, K. Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K. Nakagawara, E. N. Kodama, Y, Oshima
    • Journal Title

      Nature Chemistry

      Volume: 7 Pages: 737-743

    • DOI
      10.1038/nchem.2308
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460117, KAKENHI-PROJECT-25670255, KAKENHI-PROJECT-25293022
  • [Journal Article] Histone chaperone CAF-1 mediatesrepressive histone modifications to protect preimplantation mouse embryos from endogenousretrotransposons.2015

    • Author(s)
      Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodam E, Ohkawa Y, Tsukada Y, Ogura A.
    • Journal Title

      Proceedings of the National Academy of Sciences U.S.A

      Volume: 112 Pages: 14641-14646

    • DOI
      10.1073/pnas.1512775112
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430100, KAKENHI-PROJECT-15K18545, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112008, KAKENHI-PLANNED-25116010, KAKENHI-PROJECT-25670255, KAKENHI-PROJECT-26290064
  • [Journal Article] Delayed emergence of HIV-1 variants resistant to 4′-ethynyl-2-fluoro-2′-deoxyadeno -sine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-9860012014

    • Author(s)
      Kenji Maeda, Darshan V Desai, Manabu Aoki, Hirotomo Nakata, Eiichi N Kodama, Hiroaki Mitsuya
    • Journal Title

      Antivir Ther

      Volume: 19 Pages: 179-189

    • DOI
      10.3851/imp2697
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791031, KAKENHI-PROJECT-25670255, KAKENHI-PROJECT-26461510
  • [Journal Article] 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-12014

    • Author(s)
      Eleftherios Michailidis, Andrew D. Huber, Emily M. Ryan, Yee T. Ong, Maxwell D. Leslie, Kayla B. Matzek, Kamalendra Singh, Bruno Marchand, Ariel N. Hagedorn, Karen A. Kirby, Lisa C. Rohan, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, and Stefan G. Sarafianos.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Pages: 24533-24548

    • DOI
      10.1074/jbc.m114.562694
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-25670255
  • [Journal Article] Current research on chronic active Epstein-Barr virus infection in Japan2014

    • Author(s)
      Fujiwara S, Kimura H, Imadome K, Arai A, Kodama, E, Morio T, Shimizu N, and Wakiguchi H.
    • Journal Title

      Pediatr Int

      Volume: 56 Pages: 159-166

    • DOI
      10.1111/ped.12314
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591375, KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24659493, KAKENHI-PROJECT-25293109, KAKENHI-PROJECT-25670255
  • [Journal Article] Evaluation of combinations of 4'-ethynyl-2-fluoro-2'-deoxyadenosine with clinically used antiretroviral drugs.2013

    • Author(s)
      Atsuko Hachiya, Aaron Reeve, Bruno Marchand, Eleftherios Michailidis, Yee Ong, Karen Kirby, Maxwell Leslie, Shinichi Oka, Eiichi Kodama, Lisa Rohan, Hiroaki Mitsuya, Michael Parniak, and Stefan Sarafianos
    • Journal Title

      Antimicrobal Agents and Chemotherapy

      Volume: 57 Pages: 4554-4558

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains2013

    • Author(s)
      Kazuki Shimane, KumiKawaji, Fusako Miyamoto, Shinya Oishi, Kentaro Watanabe, YasukoSakagami, Nobutaka Fujii, Kazuya Shimura, Masao Matsuoka, Mitsuo Kaku, Stefan Sarafianos, and Eiichi Kodama
    • Journal Title

      Antimicrobal Agents and Chemotherapy

      Volume: 57 Pages: 4035-4038

    • Data Source
      KAKENHI-PROJECT-25670255
  • [Journal Article] Mechanism of Resistance to S138A Substituted Enfuvirtide and its Application to Peptide Design2013

    • Author(s)
      Kazuki Izumi, Kumi Kawaji, Fusasko Miyamoto, Kazuki Shimane, Kazuya Shimura, Yasuko Sakagami, Toshio Hattori, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Mitsuo Kaku, Stefan G. Sarafianos, and Eiichi N. Kodama
    • Journal Title

      International Journal of Biochemistry and Cell Biology

      Volume: 45 Pages: 908-915

    • Data Source
      KAKENHI-PROJECT-25670255
  • [Journal Article] Development of small molecule HIV-1 fusion inhibitors: linking Biology to Chemistry. Current Pharmaceutical Design2013

    • Author(s)
      Fusako Miyamoto and Eiichi N Kodama
    • Journal Title

      Current Pharmaceutical Design

      Volume: 19 Pages: 1827-1834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Hypersusceptibility Mechanism of Tenofovir-Resistant HIV to EFdA2013

    • Author(s)
      Eleftherios Michailidis, Emily M Ryan, Atsuko Hachiya, Karen A Kirby, Bruno Marchand, Maxwell D Leslie, Andrew D Huber, Yee T Ong, Jacob C Jackson, Kamalendra Singh, Eiichi N Kodama, Hiroaki Mitsuya, Michael A Parniak and Stefan G Sarafianos
    • Journal Title

      Retrovirology

      Volume: 10 Pages: 65-65

    • DOI
      10.1186/1742-4690-10-65
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-25670255
  • [Journal Article] Evaluation of combinations of 4'-ethynyl-2-fluoro-2'-deoxyadenosine with clinically used antiretroviral drugs2013

    • Author(s)
      Atsuko Hachiya, Aaron Reeve, Bruno Marchand, Eleftherios Michailidis, Yee Ong, Karen Kirby, Maxwell Leslie, Shinichi Oka, Eiichi Kodama, Lisa Rohan, Hiroaki Mitsuya, Michael Parniak, and Stefan Sarafianos
    • Journal Title

      Antimicrobal Agents and Chemotherapy

      Volume: 57 Pages: 4554-4558

    • Data Source
      KAKENHI-PROJECT-25670255
  • [Journal Article] Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design2013

    • Author(s)
      Izumi K, Kawaji K, Miyamoto F, Shimane K, Shimura K, Sakagami Y, Hattori T, Watanabe K, Oishi S, Fujii N, Matsuoka M, Kaku M, Sarafianos SG, Kodama EN.
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 45 Pages: 908-15

    • DOI
      10.1016/j.biocel.2013.01.015
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791021
  • [Journal Article] Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.2013

    • Author(s)
      Kazuki Izumi, Kumi Kawaji, Fusasko Miyamoto, Kazuki Shimane, Kazuya Shimura, Yasuko Sakagami, Toshio Hattori, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Mitsuo Kaku, Stefan G. Sarafianos, and Eiichi N. Kodama
    • Journal Title

      Int. J. Biovjem. Cell Biol.

      Volume: 45 Pages: 908-915

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] 新しい抗ウイルス剤開発の考え方2013

    • Author(s)
      児玉栄一、宮本総子
    • Journal Title

      臨床と微生物

      Volume: 40 Pages: 51-55

    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Sarafianos SG.Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine2013

    • Author(s)
      Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA
    • Journal Title

      Antimicrobal Agents and Chemotherapy

      Volume: 57 Pages: 6254-6264

    • Data Source
      KAKENHI-PROJECT-25670255
  • [Journal Article] Development of Small Molecule HIV-1 Fusion Inhibitors: Linking Biology to Chemistry.2013

    • Author(s)
      Miyamoto F, Kodama EN
    • Journal Title

      Curr Pharm Des.

      Volume: 19 Pages: 1827-1834

    • DOI
      10.2174/1381612811319100007
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Journal Article] HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains2013

    • Author(s)
      Kazuki Shimane, KumiKawaji, Fusako Miyamoto, Shinya Oishi, Kentaro Watanabe, YasukoSakagami, Nobutaka Fujii, Kazuya Shimura, Masao Matsuoka, Mitsuo Kaku, Stefan Sarafianos, and Eiichi Kodama
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 57 Pages: 4035-4038

    • DOI
      10.1128/aac.00237-13
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254, KAKENHI-PROJECT-24791021
  • [Journal Article] Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine2013

    • Author(s)
      Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG.
    • Journal Title

      Antimicrobal Agents and Chemotherapy

      Volume: 57 Pages: 6254-6264

    • DOI
      10.1128/aac.01703-13
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Development of Small Molecule HIV-1 Fusion Inhibitors: Linking Biology to Chemistry.2012

    • Author(s)
      Miyamoto F, Kodama EN.
    • Journal Title

      Curr Pharm Des.

      Volume: 19 Pages: 1827-1834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] HIV-1 re- verse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors2012

    • Author(s)
      Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Pages: 29988-29999

    • DOI
      10.1074/jbc.m112.351551
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-24390254
  • [Journal Article] Biochemical,inhibition and inhibitor resistancestudies of xenotropic murine leukemiavirus-related virus reversetranscriptase.2012

    • Author(s)
      Tanyaradzwa P. Ei-Ichi Kodama, et al.
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Pages: 345-359

    • DOI
      10.1093/nar/gkr694
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-24659484
  • [Journal Article] Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.2012

    • Author(s)
      Michailidis E, Singh K, Ryan EM, Hachiya A, Ong YT, Kirby KA, Marchand B, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG
    • Journal Title

      Cell Mol Biol (Noisy-le-grand).

      Volume: 58 Pages: 187-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Development and application of fluorescent SDF-1 derivatives.2012

    • Author(s)
      Ryo Masuda, Shinya Oishi, Noriko Tanahara, Hiroaki Ohno, Akira Hirasawa, Gozoh Tsujimoto, Eiichi Kodama, Masao Matsuoka and Nobutaka Fujii
    • Journal Title

      Future Med Chem.

      Volume: 4 Pages: 837-844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 re- verse transcriptase mutant2012

    • Author(s)
      Michailidis E, Singh K, Ryan EM, Hachiya A, Ong YT, Kirby KA, Marchand B, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.
    • Journal Title

      Cell Mol Biol(Noisy-le-grand)

      Volume: 58 Pages: 187-195

    • DOI
      10.1155/2012/586401
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Journal Article] Development and application of fluorescent SDF-1 derivatives.2012

    • Author(s)
      Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Kodama E, Matsuoka M, Fujii N.
    • Journal Title

      Future Medicinal Chemistry

      Volume: 4 Pages: 837-844

    • DOI
      10.4155/fmc.12.31
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390025, KAKENHI-PROJECT-23590636, KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-23689007
  • [Journal Article] Biochemical, inhibition, and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.2012

    • Author(s)
      TP. Ndongwe, AO. Adedeji, E Michailidis, YT Ong, A Hachiya, B Marchand, EM. Ryan, DK. Rai, KA. Kirby, AS. Whatley, DH. Burke, M Johnson, S Ding, YM Zheng, SL Liu, E Kodama, KA. Delviks-Frankenberry, VK. Pathak, H Mitsuya, MA. Parniak, K Singh, SG. Sarafianos.
    • Journal Title

      Nucleic Acids Research

      Volume: 40 Pages: 345-359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Journal Article] Epigallocatechin gallate inhibits the HIV reverse transcription step2011

    • Author(s)
      Li S, Hattori T, Kodama EN
    • Journal Title

      Antivir Chem Chemother.

      Volume: 21 Pages: 239-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23256004
  • [Journal Article] The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase2011

    • Author(s)
      Karen A. Kirby, Kamalendra Singh, Eleftherios Michailidis, Bruno Marchand, Eiichi N. Kodama, Noriyuki Ashida, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos
    • Journal Title

      Cellular and Molecular Biology

      Volume: 57 Pages: 39-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Epigallocatechin gallate inhibits HIV reverse transcription step2011

    • Author(s)
      Shenwei Li, Toshio Hattori, Eiichi N Kodama
    • Journal Title

      Antiviral Chemistry and Chemotherapy

      Volume: 21 Pages: 239-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism2011

    • Author(s)
      Hachiya A, Kodama EN, Schuckmann MM, Kirby KA, Michailidis E, Sakagami Y, Oka S, Singh K, Sarafianos SG
    • Journal Title

      PLoS One

      Volume: 6(1)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Journal Article] K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.2011

    • Author(s)
      Atsuko Hachiya, Eiichi N.Kodama, Matthew M.Schuckmann, Karen A.Kirby, Eleftherios Michailidis, Yasuko Sakagami, Shinichi Oka, Kamalendra Singh, Stefan G.Sarafianos
    • Journal Title

      PLoS One

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism2011

    • Author(s)
      Atsuko Hachiya, Eiichi N.Kodama, Matthew M.Schuckmann, Karen A.Kirby, Eleftherios Michailidis, Yasuko Sakagami, Shinichi Oka, Kamalendra Singh, Stefan G.Sarafianos
    • Journal Title

      PLoS One

      Volume: 6

    • DOI
      10.1371/journal.pone.0016242
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effect on T-202011

    • Author(s)
      Kazuki Izumi, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Stefan G. Sarafianos and Eiichi N. Kodama
    • Journal Title

      Antiviral Chemistry and Chemotherapy

      Volume: 22 Pages: 51-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Potent anti-HIV-1 activity of N-HR-derived pep tides including a deep pocket-forming region without antagonistic effect on T-202011

    • Author(s)
      Kazuki Izumi, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Stefan G.Sarafianos, Eiichi N.Kodama
    • Journal Title

      Antiviral Chemistry and Chemotherapy

      Volume: 22 Pages: 51-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] K70Q adds high-level tenofovir resistance to"Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism2011

    • Author(s)
      Atsuko Hachiya, Eiichi N. Kodama, Matthew M. Schuckmann, Karen A. Kirby, Eleftherios Michailidis, Yasuko Sakagami, Shinichi Oka, Kamalendra Singh, Stefan G. Sarafianos
    • Journal Title

      PLoS One

      Volume: 6 Pages: 16242-16242

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] The Sugar Ring Conformation of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine and its Recognition by the Polymerase Active Site of HIV Reverse Transcriptase.2011

    • Author(s)
      Karen A.Kirby, Kamalendra Singh, Eleftherios Michailidis, Bruno Marchand, Eiichi N.Kodama, Noriyuki Ashida, Hiroaki Mitsuya, Michael A.Parniak, Stefan G.Sarafianos.
    • Journal Title

      Cellular and Molecular Biology

      Volume: 57 Pages: 39-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase2011

    • Author(s)
      Kirby KA, Singh K, Michailidis E, Marchand B, Kodama EN, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG
    • Journal Title

      Cell Mol Biol (Noisy-le-grand)

      Volume: 57(1) Pages: 40-6

    • URL
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119259/
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Journal Article] Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants.2010

    • Author(s)
      Shinya Oishi, Kentaro Watanabe, Saori Ito, Michinori Tanaka, Hiroki Nishikawa, Hiroaki Ohno, Kazuki Shimane, Kazuki Izumi, Yasuko Sakagami, Eiichi N.Kodama, Masao Matsuoka, Akira Asai, Nobutaka Fujii
    • Journal Title

      Medicinal Chemistry Communications

      Volume: 1 Pages: 276-281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.2010

    • Author(s)
      Matthew Michael Schuckmann, Bruno Marchand, Atsuko Hachiya, Eiichi N.Kodama, Karen A.Kirby, Kamalendra Singh, Stefan G.Sarafianos.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 38700-38709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors2010

    • Author(s)
      Kazuya Shimura, Daisuke Nameki, Keiko Kajiwara, Kentaro Watanabe, Yasuko Sakagami, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Stefan G. Sarafianos, Eiichi N. Kodama
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 39471-39480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Rev-derived peptides inhibit HIV 1 replication by antagonism of Rev and a co-receptor, CXCR4.2010

    • Author(s)
      Kazuki Shimane, Eiichi N.Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G.Sarafianos,Masao Matsuoka
    • Journal Title

      Internatianal Journal of Biochemistry and Cell Biology

      Volume: 42 Pages: 1482-1488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of HIV-1 gp120 and Their Antiviral Activity.2010

    • Author(s)
      Kenji Watanabe, Shigeru Negi, Yukio Sugiura, Akiko Kiriyama, Akino Honbo, Katsumi Iga, Eiichi N.Kodama, Takeshi Naitoh, Masao Matsuoka, Koji Kano.
    • Journal Title

      Chemistry-An Asian Journal 5

      Pages: 825-834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of HIV-1 gp120 and Their Antiviral Activity.2010

    • Author(s)
      Kenji Watanabe, Shigeru Negi, Yukio Sugiura, Akiko Kiriyama, Akino Honbo, Katsumi Iga, Eiichi N.Kodama, Takeshi Naitoh, Masao Matsuoka, Koji Kano
    • Journal Title

      Chemistry-An Asian Journal

      Volume: 5 Pages: 825-834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR42010

    • Author(s)
      Kazuki Shimane, Eiichi N. Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G. Sarafianos, Masao Matsuoka
    • Journal Title

      International Journal of Biochemistry and Cell Biology

      Volume: 42 Pages: 1482-1488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Synthesis and Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres2010

    • Author(s)
      Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, and Nobutaka Fujii
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 8 Pages: 616-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Synthesis and Biological Evaluatian of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres.2010

    • Author(s)
      Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 8 Pages: 616-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Binding of Multivalent Anionic Porphyrins to V3 Loop Fragments of HIV-1 gp120 and Their Antiviral Activity2010

    • Author(s)
      Kenji Watanabe, Shigeru Negi, Yukio Sugiura, Akiko Kiriyama, Akino Honbo, Katsumi Iga, Eiichi N. Kodama, Takeshi Naitoh, Masao Matsuoka, and Koji Kano
    • Journal Title

      Chemistry-An Asian Journal

      Volume: 5 Pages: 825-834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine2010

    • Author(s)
      Matthew Michael Schuckmann, Bruno Marchand, Atsuko Hachiya, Eiichi N. Kodama, Karen A. Kirby, Kamalendra Singh, Stefan G. Sarafianos
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 38700-38709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants2010

    • Author(s)
      Shinya Oishi, Kentaro Watanabe, Saori Ito, Michinori Tanaka, Hiroki Nishikawa, Hiroaki Ohno, Kazuki Shimane, Kazuki Izumi, Yasuko Sakagami, Eiichi N. Kodama, Masao Matsuoka, Akira Asai and Nobutaka Fujii
    • Journal Title

      Medicinal Chemistry Communications

      Volume: 1 Pages: 276-281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Synthesis and Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres.2010

    • Author(s)
      Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii.
    • Journal Title

      Organic & Biomolecular Chemistry 8

      Pages: 616-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Resistance profiles of novel electrostatically constrained HIV 1 fusion inhibitors.2010

    • Author(s)
      Kazuya Shimura, Daisuke Nameki, Keiko Kajiwara, Kentaro Watanabe, Yasuko Sakagami, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Stefan G.Sarafianos, Eiichi N.Kodama
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 39471-39480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat.2010

    • Author(s)
      Kazuki Izumi, Shota Nakamura, Hiroaki Nakano, Kazuya Shimura, Yasuko Sakagami, Shinya Oishi, Susumu Uchiyama, Tadayasu Ohkubo, Yuji Kobayashi, Nobutaka Fujii, Masao Matsuoka, Eiichi N.Kodama
    • Journal Title

      Antiviral Research

      Volume: 87 Pages: 179-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat2010

    • Author(s)
      Kazuki Izumi, Shota Nakamura, Hiroaki Nakano, Kazuya Shimura, Yasuko Sakagami, Shinya Oishi, Susumu Uchiyama, Tadayasu Ohkubo, Yuji Kobayashi, Nobutaka Fujii, Masao Matsuoka, Eiichi N. Kodama
    • Journal Title

      Antiviral Research

      Volume: 87 Pages: 179-186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Procyanidin B-1 purified from Cinnamomi Cortex suppresses HCV replication2010

    • Author(s)
      Shenwei Li, Eiichi N Kodama, Yuuki Inoue, Hideki Tani, Yoshiharu Matsuura, Jing Zhang, Takashi Tanaka, Toshio Hattori
    • Journal Title

      Antiviral Chemistry and Chemotherapy

      Volume: 20 Pages: 239-248

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article]2010

    • Author(s)
      児玉栄一, 他
    • Journal Title

      新規抗HIV薬の開発 特集・抗ウイルス薬物療法の現状と今後の展望(医薬ジャーナル)

      Pages: 99-102

    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-ethynyl-2-fluoro-2'-doxyadenosine triphosphate, a translocation defective reverse transcriptase inhibitor.2009

    • Author(s)
      Eleftherios Michailidis, Bruno Marchand, Eiichi N.Kodama, Kamlendra Singh, Masao Matsuoka, Karen A.Kirby, Emily M.Ryan, Ali M.Sawani, Eva Nagy, Noriyuki Ashida, Hiroaki Mitsuya, Michael A.Parniak, Stefan G.Sarafianos.
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 35681-35691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Electrostatically constrained α-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide.2009

    • Author(s)
      Hiroki Nishikawa, Shota Nakamura, Eiichi Kodama, Saori Ito, Keiko Kajiwara, Kazuki Izumi, Yasuko Sakagami, Shinya Oishi, Tadayasu Ohkubo, Yuji Kobayashi, Akira Otaka, Nobutaka Fujii, Masao Matsuoka
    • Journal Title

      International Journal of Biochemistry and Cell Biology 41

      Pages: 891-899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution.2009

    • Author(s)
      Tsuyoshi Watabe, Yukihiro Terakawa, Kentaro Watanabe, Hiroaki Ohno, Hiroaki Nakano, Toru Nakatsu, Hiroaki Kato, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Kazuo Kitaura, Shinya Oishi, Nobutaka Fujii.
    • Journal Title

      Journal of Molecular Biology 392

      Pages: 657-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Bioorganic Synthesis of a Recombinant HIV-1 Fusion Inhibitor, SC35EK, with an N-Terminal Pyroglutamate Capping Group2009

    • Author(s)
      Kazumi Kajiwara, Kentaro Watanabe, Rei Tokiwa, Tomoko Kurose, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, and Nobutaka Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-ethynyl-2-fluoro-2'-doxyadenosine triphosphate, a translocation defective reverse transcriptase inhibitor2009

    • Author(s)
      Eleftherios Michailidis, Bruno Marchand, Eiichi N. Kodama, Kamlendra Singh, Masao Matsuoka, Karen A. Kirby, Emily M. Ryan, Ali M. Sawani, Eva Nagy, Noriyuki Ashida, Hiroaki Mitsuya, Michael A. Parniak, and Stefan G. Sarafianos
    • Journal Title

      Journal of Biological Chemistry

      Volume: 284 Pages: 35681-35691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Clinical relevance of substitutions in the connection subdomain and R Nase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients.2009

    • Author(s)
      Atsuko Hachiya, Kazuki Shimane, Stefan G.Sarafianos, Eiichi N.Kodama, Yasuko Sakagami, Fujie Negishi, Hirokazu Koizumi, Hiroyuki Gatanaga, Masao Matsuoka, Masafumi Takiguchi, Shinichi Oka.
    • Journal Title

      Antiviral Research 82

      Pages: 115-121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Peptide bond mimicry by(E)-alkene and(Z)-fluoroalkene peptide isosteres : synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues2009

    • Author(s)
      Shinya Oishi, Hirotaka Kamitani, Yasuyo Kodera, KentaroWatanabe, Kazuya Kobayashi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka and Nobutaka Fujii
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 7 Pages: 2872-2877

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article]2009

    • Author(s)
      児玉栄一、服部俊夫, 他
    • Journal Title

      HIV感染症と増殖のメカニズム-抗ウイルス剤の作用点を中心に- 特集HIV感染症 流行の現状と最新の治療(日本内科学会雑誌)

      Pages: 2754-2761

    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Clinical relevance of substitutions in the connection subdomain and RNase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients2009

    • Author(s)
      Atsuko Hachiya, Kazuki Shimane, Stefan G. Sarafianos, Eiichi N. Kodama, Yasuko Sakagami, Fujie Negishi, Hirokazu Koizumi, Hiroyuki Gatanaga, Masao Matsuoka, Masafumi Takiguchi, Shinichi Oka
    • Journal Title

      Antiviral Research

      Volume: 82 Pages: 115-121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Bioorganic Synthesis of End-capped Anti-HIV Peptides by Simultaneous Cyanocysteine-mediated Cleavages of Recombinant Proteins2009

    • Author(s)
      Michinori Tanaka, Kazumi Kajiwara, Rei Tokiwa, Kentaro Watanabe, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 17 Pages: 7487-7492

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres : synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues.2009

    • Author(s)
      Shinya Oishi, Hirotaka Kamitani, Yasuyo Kodera, Kentaro Watanabe, Kazuya Kobayashi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Nobutaka Fujii
    • Journal Title

      Organic & Biomolecular Chemistry 7

      Pages: 2872-2877

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] SC29EK, a peptide fusion inhibitor with enhanced α-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.2009

    • Author(s)
      akeshi Naito, Kazuki Izumi, Eiichi Kodama, Yasuko Sakagami, Keiko Kajiwara, Hiroki Nishikawa, Kentaro Watanabe, Stefan G.Sarafianos, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka.
    • Journal Title

      Antimicrobal Agents and Chemotherapy 53

      Pages: 1013-1018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Bioorganic Synthesis of End-capped Anti-HIV Peptides by Simultaneous Cyanocysteine-mediated Cleavages of Recombinant Proteins.2009

    • Author(s)
      Michinori Tanaka, Kazumi Kajiwara, Rei Tokiwa, Kentaro Watanabe, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry 17

      Pages: 7487-7492

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide.2009

    • Author(s)
      Mariko Ueno, Eiichi N.Kodama, Kazuya Shimura, Yasuteru Sakurai, Keiko Kajiwara, Yasuko Sakagami, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka.
    • Journal Title

      Antiviral Research 82

      Pages: 67-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Design of peptide-based inhibitors for HIV-1 strains resistant to T-202009

    • Author(s)
      Kazuki Izumi, Eiichi Kodama, Kazuya Shimura, Yasuko Sakagami, Kentaro Watanabe, Saori Ito, Tsuyoshi Watabe, Yukihiro Terakawa, Hiroki Nishikawa, Stefan G.Sarafianos, Kazuo Kitaura, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 4914-4920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus2009

    • Author(s)
      Shinya Oishi, Yasuyo Kodera, Hiroki Nishikawa, Kamitani H, Tsuyoshi Watabe, Hiroaki Ohno, Tadafumi Tochikura, Kazuki Shimane, Eiichi Kodama, Masao Matsuoka, Fuminori Mizukoshi, Hajime Tsujimoto H, Nobutaka Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 17 Pages: 4916-4920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus.2009

    • Author(s)
      Shinya Oishi, Yasuyo Kodera, Hiroki Nishikawa, Kamitani H, Tsuyoshi Watabe, Hiroaki Ohno, Tadafumi Tochikura, Kazuki Shimane, Eiichi Kodama, Masao Matsuoka, Fuminori Mizukoshi, Hajime Tsujimoto H, Nobutaka Fujii
    • Journal Title

      Bioorganic & Medicinal Chemistry 17

      Pages: 4916-4920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Bioorganic Synthesis of a Recombinant HIV-1 Fusion Inhibitor, SC35EK, with an N-Terminal Pyroglutamate Capping Group.2009

    • Author(s)
      Kazumi Kajiwara, Kentaro Watanabe, Rei Tokiwa, Tomoko Kurose, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii.
    • Journal Title

      Bioorganic & Medicinal Chemistry 17

      Pages: 7964-7970

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution2009

    • Author(s)
      Tsuyoshi Watabe, Yukihiro Terakawa, Kentaro Watanabe, Hiroaki Ohno, Hiroaki Nakano, Toru Nakatsu, Hiroaki Kato, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Kazuo Kitaura, Shinya Oishi, Nobutaka Fujii
    • Journal Title

      Journal of Molecular Biology

      Volume: 392 Pages: 657-665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Journal Article] Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects

    • Author(s)
      Watanabe K, Oishi S, Fujii on T-20.Izumi K, N, Matsuoka M, Sarafianos SG, Kodama EN
    • Journal Title

      Antivir Chem

    • DOI
      10.3851/imp1836
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] ゲンボイヤ配合錠(GEN;EVG/COBI/FTC/TAF)投与時の耐性発現症例の検討2017

    • Author(s)
      田沼順子,潟永博之,岡慎一,児玉栄一,中本泰充,池田篤史,小倉直樹,Michael E. Abram,Nicolas A. Margot,Stephanie Cox,Christian Callebaut,Moupali Das
    • Organizer
      第31回日本エイズ学会
    • Data Source
      KAKENHI-PROJECT-16H05346
  • [Presentation] Characteristics of Hospital Damage and Challenges of Disaster Mitigation Related to the 2016Kumamoto Earthquakes in Japan.2017

    • Author(s)
      Hitomi Maeda, Satoko Iyama, Chiharu Matsumoto, Kimiyo Nanke and Eiichi Kodama
    • Organizer
      International Nursing Research Conference 2017
    • Data Source
      KAKENHI-PROJECT-16H05346
  • [Presentation] tructural Basis of Inhibitionand Resistance Mechanism to EFdA,a highly potent NRTI2016

    • Author(s)
      Zhe Li, Karen A. Kirby, Bruno Marchand, Eleftherios Michailidis, Eiichi N.Kodama, Lisa C.Rohan, Hiroaki Mitsuya, Michael A. Parniak, and Stefan G. Sarafianos.
    • Organizer
      Cold Spring Harbor Laboratory Meetings Retroviruses
    • Place of Presentation
      New York City(USA)
    • Year and Date
      2016-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05346
  • [Presentation] ジョロウグモ内生糸状菌のポストゲノム型天然物探索2016

    • Author(s)
      浅井禎吾,塚田健人,森下陽平,伊藤史織,網谷雄志,岡崎裕亮,児玉栄一,大島吉輝
    • Organizer
      第58回天然物有機化合物討論会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-14
    • Data Source
      KAKENHI-PROJECT-16H05346
  • [Presentation] Profile of a novel HIV reverse transcriptase inhibitor2013

    • Author(s)
      Fusako Miyamoto, Fumiko Tomiyama, Kumi Kawaji, Mitsuo Kaku, Eiichi Kodama
    • Organizer
      NIH Tohoku University JSPS Symposium
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24390254
  • [Presentation] The Combination of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Rilpivirine Shows Synergistic Anti-HIV-1 Activ- ity In Vitro2012

    • Author(s)
      Atsuko Hachiya, Bruno Marchand, Eleftherios Michailidis, Eiichi N Kodama, Michael A Parni- ak, Hiroaki Mitsuya, Shinichi Oka, Stefan G Sarafianos
    • Organizer
      25th In- ternational Conference on Antiviral Research
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] The Combination of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Rilpivirine Shows Synergistic Anti-HIV-1 Activity In Vitro.2012

    • Author(s)
      Atsuko Hachiya, Bruno Marchand, Eleftherios Michailidis, Eiichi N Kodama, Michael A Parniak, Hiroaki Mitsuya, Shinichi Oka, Stefan G Sarafianos.
    • Organizer
      25th International Conference on Antiviral Research.
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] Effect of 4'- and 2-NRTI Substitutions on the Inhibition Mechanism of HIV Reverse Transcriptase and Toxicity.2012

    • Author(s)
      Eleftherios Michailidis, Jordan Wilkins, Emily M. Ryan, Atsuko Hachiya, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos.
    • Organizer
      25th International Conference on Antiviral Research.
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] Effect of 4'- and 2-NRTI Substitu- tions on the Inhibition Mechanism of HIV Re- verse Transcriptase and Toxicity2012

    • Author(s)
      Eleftherios Michailidis, Jordan Wilkins, Emily M. Ryan, Atsuko Hachiya, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos
    • Organizer
      25th In- ternational Conference on Antiviral Research
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] A novel peptide derived from measles virus fusion protein inhibits the replication of subacute sclerosing panencephalitis (SSPE) virus in vitro and in vivo.2012

    • Author(s)
      Masahiro Watanabe, Koichi Hashimoto, Yusaku Abe, Eiichi Kodama, Ryota Nabika, Shinya Oishi, Nobutaka Fujii, Mitsuaki Hosoya
    • Organizer
      25th International Conference on Antiviral Research.
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] Sustained Activity of 4'-Ethynyl Nucleosides to Variants with M184V Mutation in HIV-1 Reverse Transcriptase.2012

    • Author(s)
      Fusako Miyamoto, Kumi Kawaji, Toshio Hattori, Hiroaki Mitsuya, Stefan G. Sarafianos, Eiichi N. Kodama.
    • Organizer
      25th International Conference on Antiviral Research.
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), a translocation defective reverse transcriptase inhibitor with highly potent activity against diverse multi-drug-resistant HIV-1 variants.2012

    • Author(s)
      Hiroaki Mitsuya, Eiichi Kodama, Hirotomo Nakata, Shinichro Hattori, Seiji Okada, Kenji Maeda, Michael A. Parniak, and Stefan G. Sarafianos.
    • Organizer
      13th Kmamoto AIDS Seminar-GCOE Joint International Symposium
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] Combinations of 4'-ethynyl-2-fluoro-2'-deoxyadenosine with rilpivirine show synergistic anti-HIV activity in vitro.2012

    • Author(s)
      Atsuko Hachiya, Eiichi N. Kodama et al.
    • Organizer
      13th Kmamoto AIDS Seminar-GCOE Joint International Symposium
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] Sustained Activity of 4'-Ethynyl Nucleosides to Variants with M184V Mutation in HIV-1 Reverse Transcriptase2012

    • Author(s)
      Fusako Miyamoto,Kumi Kawaji,Toshio Hattori, Hiroaki Mitsuya, Stefan G Sarafianos is, Eiichi N Kodama
    • Organizer
      25th In- ternational Conference on Antiviral Research
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-23590636
  • [Presentation] 4'-Ethynyl-核酸誘導体に対するHIV-1およびHIV-2の耐性機序2011

    • Author(s)
      宮本総子, 服部俊夫, 児玉栄一
    • Organizer
      第25回エイズ学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23256004
  • [Presentation] Effect of 4'- and 2-NRTI Substitutions on the Inhibition Mechanism of HIV Reverse Transcriptase2011

    • Author(s)
      Eleftherios Michailidis, Stephen H.Hughes, Emily M.Ryan, Atsuko Hachiya, Devendra Rai, Jordan Wilkins, Kamlendra Singh, Bruno Marchand, Mark Hannink, B.Christie Vu, Victor Marquez, Ei-Ichi Kodama, Hiroaki Mitsuya, Michael A.Parniak, Stefan G.Sarafianos
    • Organizer
      12th Annual Symposium on Antiviral Drug Resistanee
    • Place of Presentation
      ペンシルバニア アメリカ
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] HIV-1 Reverse Transcriptase(RT)Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Nonnucleoside RT Inhibitors2011

    • Author(s)
      Atsuko Hachiya, Bruno Marchand, Karen A. Kirby, Eleftherios Michailidis, Xiongying Tu, Yee Tsuey Ong, Daniel T. Griffin, Matthew M. Schuckmann, Junko Tanuma, Shinichi Oka, Kamalendra Singh, Eiichi N. Kodama and Stefan G. Sarafianos
    • Organizer
      12th Annual Symposium on Antiviral Drug Resistance, Hershey, Pennsylvania
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] HIV-1 Reverse Transcriptase Polymorphism 172K Suppresses the Effect of Clinical Resistance Mutations to both NRTI and NNRTI2011

    • Author(s)
      Atsuko Hachiya, Matthew M. Schuckmann, D Griffin, Karen A. Kirby, YT Ong Junko Tanuma, Shinichi Oka, Kamlendra Singh, Eiichi N. Kodama, Stefan G. Sarafianos
    • Organizer
      8th conference on retroviruses and opportunistic infections Boston, MA
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Development of HIV-1 fusion inhibitors active to enfuvirtide resistant variants2011

    • Author(s)
      Eiichi N. Kodama
    • Organizer
      US-Japan Joint AIDS Panel : Resistance Meeting, Singapore
    • Place of Presentation
      Invited
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effeet of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Nonnucleoside RT Inhibitors2011

    • Author(s)
      Atsuko Hachiya, Bruno Marchand, Karen A.Kirby, Eleftherios Michailidis, Xiongying Tu, Yee Tsuey One, Daniel T.Griffin, Matthew M.Schuckmann, Junko Tanuma, Shinichi Oka, Kamalendra Singh, Eiichi N.Kodama, Stefan G.Sarafianos
    • Organizer
      12th Annual Symposium on Antiviral Drug Resistanee
    • Place of Presentation
      ペンシルバニア アメリカ
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] HIV-1 Reverse Transcriptase Polymorphism 172K Suppresses the Effect of Clinical Resistance Mutations to both NRTI and NNRTI.2011

    • Author(s)
      Atsuko Hachiya, Matthew M.Schuckmann, D Griffin, Karen A.Kirby, YT Ong Junko Tanuma, Shinichi Oka, Kamlendra Singh, Eiichi N.Kodama, Stefan G.Sarafianos.
    • Organizer
      18th conference on retroviruses and opportunistic infections Boston, MA
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2011-02-27
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Effect of 4'-and2-NRTI Substitutions on the Inhibition Mechanism of HIV Reverse Transcriptase2011

    • Author(s)
      Eleftherios Michailidis, Stephen H. Hughes, Emily M. Ryan, Atsuko Hachiya, Devendra Rai, Jordan Wilkins, Kamlendra Singh, Bruno Marchand, Mark Hannink, B. Christie Vu, Victor Marquez, Ei-Ichi Kodama, Hiroaki Mitsuya, Michael A. Parniak, and Stefan G. Sara
    • Organizer
      12th Annual Symposium on Antiviral Drug Resistance, Hershey, Pennsylvania
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Development of HIV-1 fusion inhibitors active to enfuvirtide resistant variants.2010

    • Author(s)
      Eiichi N.Kodama
    • Organizer
      US-Japan Joint AIDS Panel : Resistance Meeting, Singapore
    • Place of Presentation
      シンガポール Grans Copthorne Waterfront Hotel(招待講演)
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Parniak 4'-Ethynyl-2-fluoro-2'-deoxyadenosine(EFDA), a translocation defective reverse transcriptase inhibitor with highly potent activity against diverse multi-drug-resistant HIV-1 variants2009

    • Author(s)
      Hiroaki Mitsuya, Stefan G. Sarafianos, Eiichi Kodama, Hirotomo Nakata, Seiji Okada, and Michael A
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Drug design for resistant HIV2009

    • Author(s)
      Kodama E.
    • Organizer
      10th Kumamoto AIDS seminar/AIDS GCOE International Symposium Satellite symposium
    • Place of Presentation
      熊本(招待講演)
    • Year and Date
      2009-09-30
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] The NNRTI-resistant Y181C HIV-1 reverse transcriptase is hyper-susceptible to 4'-ethynyl-2-fluoro deoxyadenosine(EFDA)2009

    • Author(s)
      Yee Tsuey Ong, Eleftherios Michailidis, Bruno Marchand, Matthew S. Schuckmann, Kamlendra Singh, Ei-Ichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Eva Nagy, Michael A. Parniak, and Stefan G. Sarafianos
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Parniak 4'-Ethynyl-2-fluoro-2'-deoxyadenosine(EFDA), a translocation defective reverse transcriptase inhibitor with highly potent activity against diverse multi-drug-resistant HIV-1 variants.2009

    • Author(s)
      Hiroaki Mitsuya, Stefan G.Sarafianos, Eiichi Kodama, Hirotomo Nakata, Seiji Okada, Michael A.
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance
    • Place of Presentation
      アメリカ、リッチモンド
    • Year and Date
      2009-11-15
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Drug design for resistant HIV2009

    • Author(s)
      Kodama E
    • Organizer
      10th Kumamoto AIDS seminar/AIDS GCOE International Symposium Satellite symposium, Kumamoto, Japan
    • Place of Presentation
      Invited
    • Year and Date
      2009-09-30
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] K70Q expands multi-drug resistance (MDR) of HIV-1 containing "Q151M complex" reverse transcriptase mutations.2009

    • Author(s)
      Atsuko Hachiya, Eiichi N.Kodama, Matthew M.Schuckmann, Karen A.Kirby, Eleftherios Michailidis, Yasuko Sakagami, Kamlendra Singh, Shinichi Oka, Stefan G.Sarafianos.
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance
    • Place of Presentation
      アメリカ、リッチモンド
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] K70Q expands multi-drug resistance(MDR)of HIV-1 containing"Q151M complex" reverse transcriptase mutations2009

    • Author(s)
      Atsuko Hachiya, Eiichi N. Kodama, Matthew M. Schuckmann, Karen A. Kirby, Eleftherios Michailidis, Yasuko Sakagami, Kamlendra Singh, Shinichi Oka, and Stefan G. Sarafianos
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] The NNRTI-resistant Y181C HIV-1 reverse transcriptase is hyper-susceptible to 4'-ethynyl-2-fluoro deoxyadenosine(EFDA)2009

    • Author(s)
      Yee Tsuey Ong, Eleftherios Michailidis, Bruno Marchand, Matthew S.Schuckmann, Kamlendra Singh, Ei-Ichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Eva Nagy, Michael A.Parniak, Stefan G.Sarafianos.
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance
    • Place of Presentation
      アメリカ、リッチモンド
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Biochemical characterization of the HIV reverse transcriptase connection domain multi-class drug resistance mutation N348I2009

    • Author(s)
      Matthew Schuckmann, Atsuko Hachiya, Ei-ichi N. Kodama, Bruno Marchand, Eleftherios Michailidis, Kamlendra Singh, Yasuko Sakagami, Shinichi Oka, and Stefan G. Sarafianos
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance, Richmond, VA
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Biochemical characterization of the HIV reverse transcriptase connection domain multi-class drug resistance mutation N348I.2009

    • Author(s)
      Matthew Schuckmann, Atsuko Hachiya, Ei-ichi N.Kodama, Bruno Marchand, Eleftherios Michailidis, Kamlendra Singh, Yasuko Sakagami, Shinichi Oka, Stefan G.Sarafianos.
    • Organizer
      10th Annual Symposium on Antiviral Drug Resistance
    • Place of Presentation
      アメリカ、リッチモンド
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21590591
  • [Presentation] Structural Basis of Inhibition and Resistance Mechanism to EFdA, a Highly Potent NRTI.

    • Author(s)
      Zhe Li, Karen Kirby, Bruno Marchand, Michailidis Eleftherios, Eiichi Kodama, Hiroaki Mitsuya, Michael Parniak, Stefan Sarafianos.
    • Organizer
      The annual Conference on Retroviruses and Opportunistic Infections
    • Place of Presentation
      シアトル・アメリカ
    • Year and Date
      2015-02-23 – 2015-02-26
    • Data Source
      KAKENHI-PROJECT-25670255
  • [Presentation] Structural Basis of Inhibition and Resistance Mechanism to EFdA, a Highly Potent NRTI.

    • Author(s)
      Zhe Li, Karen Kirby, Bruno Marchand, Michailidis Eleftherios, Eiichi Kodama, Hiroaki Mitsuya, Michael Parniak, Stefan Sarafianos.
    • Organizer
      The annual Conference on Retroviruses and Opportunistic Infections
    • Place of Presentation
      シアトル・アメリカ
    • Year and Date
      2015-02-23 – 2015-02-26
    • Data Source
      KAKENHI-PROJECT-24390254
  • 1.  浅井 禎吾 (60572310)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  HATTORI Toshio (30172935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  NIKI Toshiro (40558508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  HIRASHIMA Mitsuomi (70109700)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  HAORILE Chagan-Yasutan (50624821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KUBO Toru (50444873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ASHINO Yugo (20361082)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  UENO Takamasa (10322314)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  松岡 雅雄 (10244138)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  大島 吉輝 (00111302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  菊地 晴久 (90302166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  林 宏典 (00752916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  中瀬 生彦 (40432322)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  萩原 将也 (00705056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  上田 真史 (40381967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Maeda Kenji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  SHIMURA Kazuya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  OHKAWA Yasuyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  IMADOME Kenichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  HIROSHI Kimura
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  満屋 裕明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 22.  近藤 恭光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  青木 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  中田 浩智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  藤井 信孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 26.  大石 真也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  越後貫 成美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  畑中 勇輝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  伊川 正人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  束田 裕一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  小倉 淳郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  新井 文子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  大野 浩章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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