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KAWAKAMI Junichi  川上 純一

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… Alternative Names

川上 純一  カワカミ ジユンイチ

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Researcher Number 50272539
Other IDs
Affiliation (Current) 2025: 浜松医科大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help 2009 – 2024: Hamamatsu University School of Medicine, 医学部附属病院, 教授
2015: 浜松医科大学, 医学部附属病院, 教授・薬剤部長
2011: 浜松医科大学, 医学部・附属病院, 教授
2006 – 2007: 浜松医科大学, 医学部附属病院, 教授
2005: 富山大学, 附属病院, 助教授
2001 – 2004: 富山医科薬科大学, 附属病院, 助教授
1997 – 1998: 東京大学, 医学部・附属病院, 助手
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学
Except Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
薬物動態 / 炎症性サイトカイン / オピオイド / がん悪液質 / がん性疼痛 / 有害作用 / 血液脳関門 / プレガバリン / トラマドール / 神経障害性疼痛 … More / 遺伝子多型 / 代謝物 / 緩和医療 / IL-1β / TNFα / 薬物間相互作用 / 脳移行 / 脳血管障害 / 抗てんかん薬 / AMPA受容体拮抗薬 / がん病態生理 / オピオイド系鎮痛薬 / 薬物輸送担体 / 薬物代謝酵素 / がん性疼痛緩和 / オピオイド誘発性便秘 / 個別化薬物療法 / 神経障害性疼痛治療薬 / デュロキセチン / バイオマーカー / 鎮痛補助薬 / フェンタニル / 忍容性 / 薬物代謝 / 病期 / 鎮痛効果 / がん病期 / 制酸剤 / 遺伝子変異 / ガバペンチン / CYP2D6 / α1酸性糖タンパク / アルブミン / 有害反応 / 遊離形分率 / 耐性形成 / 悪液質 / 遺伝子多 / オーダーメイド医療 / オキシコドン / オピオイド鎮痛薬 / 薬剤性痙彎 / 脳虚血 / 中枢移行性 / 薬剤性痙攣 / 脳血管 / インフルエンザウイルス / 非ステロイド性抗炎症薬 / 中枢神経系 / PGE_2 / インフルエンザ脳症 / インフルエンザ脳炎 / 解熱鎮痛剤 / in vitro / 酸化ストレス / 実験的自己免疫性脳脊髄炎ラット / 多発性硬化症 / 共培養 / アストロサイト / 脳毛細血管内皮細胞 / 痙攣 / GABAA受容体 / mRNA / アフリカツメガエル卵母細胞 / けいれん / GABA_A受容体 / 副作用 / 非ステロイド性抗炎症剤 / ニューキノロン系抗菌剤 … More
Except Principal Investigator
炎症性サイトカイン / 薬物動態 / バイオマーカー / 薬物代謝 / がん性疼痛 / オピオイド / SDF-1/CXCR4システム / 口腔マイクロバイオーム / 薬剤性顎骨壊死 / トランスポーター / 有機アニオン輸送ポリペプチド / 周産期 / OATP1B / 肝取り込みトランスポーター / サイロキシン / 妊娠 / 甲状腺ホルモン / 投与設計 / ヤヌスキナーゼ阻害薬 / JAK-STAT / 体内動態 / ヤヌスキナーゼ阻害 / 低分子分子標的薬 / 個別化薬物療法 / CYP3A / エピジェネティック因子 / CYP3A4/5 / マイクロRNA / 4β水酸化コレステロール / 血清バイオマーカー / CYP2D6 / CYP3A4 / 炎症 / 遺伝子多型 / 薬物代謝酵素 / 糖尿病薬 / 副作用 / 尿路感染症 / DPP4阻害薬 / 糖尿病治療薬 / 薬剤疫学 / がん悪液質 / 有害作用 / 中枢症状 / サイトカイン / オキシコドン / 悪液質 / 免疫関連バイオ医薬品 / スタチン / 免疫バイオ医薬品 / 薬物間相互作用 / 医療情報データベース Less
  • Research Projects

    (17 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (11 People)
  •  Strategies to prevent Medication-Related Osteonecrosis of the Jaw focusing on the CXCR4 system and oral microbiome

    • Principal Investigator
      八木 達也
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  脳血管障害時におけるAMPA受容体拮抗薬の中枢移行および薬効・有害作用の個人差の解明Principal Investigator

    • Principal Investigator
      川上 純一
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  Investigation of interindividual factors determining the clinical effects of peripherally-acting mu-opioid receptor antagonist under cancer conditionsPrincipal Investigator

    • Principal Investigator
      Kawakami Junichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  PK-PD解析に基づく自己免疫疾患に対する低分子分子標的薬の投与設計法の確立

    • Principal Investigator
      見野 靖晃
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  Kinetic analyses of thyroid hormone based on hepatic uptake transporter activity during the perinatal period

    • Principal Investigator
      Naito Takafumi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Shinshu University
      Hamamatsu University School of Medicine
  •  Investigation of interindividual variability in pharmacokinetics of and clinical responses to neuropathic pain medications in cancer patientsPrincipal Investigator

    • Principal Investigator
      Kawakami Junichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Hamamatsu University School of Medicine
  •  Prediction of opioid analgesics pharmacokinetics using the biomarkers of drug metabolizing enzyme activity in cancer patients

    • Principal Investigator
      NAITO TAKAFUMI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
  •  Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stagePrincipal Investigator

    • Principal Investigator
      Kawakami Junichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
  •  The pharmacoepidemiological study on the adverse reaction of novel therapeutic agent for type 2 diabetes mellitus and the application

    • Principal Investigator
      Imatoh Takuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Investigation of interindividual factors determining the pain relief and adverse effects of opioid analgesics in cancer cachexia

    • Principal Investigator
      NAITO TAKAFUMI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
  •  Evaluation of interaction between biotechnology-based drug and chemical drug using medical information databases

    • Principal Investigator
      SAI KIMIE
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Investigation of interindividual variability in pharmacokinetics of and clinical responses to analgesics for cancer pain reliefPrincipal Investigator

    • Principal Investigator
      KAWAKAMI Junichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
  •  Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patientsPrincipal Investigator

    • Principal Investigator
      KAWAKAMI Junichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
  •  病態時における血液脳関門の破綻と医薬品による中枢神経系副作用の発現との関係解明Principal Investigator

    • Principal Investigator
      川上 純一
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Hamamatsu University School of Medicine
      University of Toyama
  •  解熱鎮痛剤によるインフルエンザ脳炎・脳症の重症化に関する機構解明Principal Investigator

    • Principal Investigator
      川上 純一
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  中枢神経系疾患による血液脳関門の機能変化と制御機構の解明Principal Investigator

    • Principal Investigator
      川上 純一
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  ニューキノロン剤と非ステロイド性抗炎症剤との相互作用の機構解明Principal Investigator

    • Principal Investigator
      川上 純一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      The University of Tokyo

All 2023 2021 2020 2019 2017 2016 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] A reversed-phase mode LC-MS/MS method using a polysaccharide chiral selector for simultaneous quantitation of each enantiomer of tramadol and its metabolites in human plasma and evaluation of CYP-mediated stereoselective demethylation.2020

    • Author(s)
      Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
    • Journal Title

      Ther Drug Monit

      Volume: - Issue: 3 Pages: 503-511

    • DOI

      10.1097/ftd.0000000000000707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08410
  • [Journal Article] Impact of cachexia and opioid analgesic co-treatment on pregabalin pharmacokinetics and central nervous system symptoms in cancer patients.2019

    • Author(s)
      Nozomi Yoshikawa, Takafumi Naito, Tatsuya Yagi, and Junichi Kawakami
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 41 Issue: 5 Pages: 591-597

    • DOI

      10.1097/ftd.0000000000000634

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H00378, KAKENHI-PROJECT-18K06746
  • [Journal Article] Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients2016

    • Author(s)
      Sato H, Naito T, Ishida T, Kawakami J.
    • Journal Title

      Eur J Clin Pharmacol

      Volume: 72(12) Issue: 12 Pages: 1463-1470

    • DOI

      10.1007/s00228-016-2116-z

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460194
  • [Journal Article] Impact of Concomitant Antacid Administration on Gabapentin Plasma Exposure and Oral Bioavailability in Healthy Adult Subjects2012

    • Author(s)
      Yagi T, Naito T, Mino Y, Umemura K, Kawakami J.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 27 Issue: 2 Pages: 248-254

    • DOI

      10.2133/dmpk.DMPK-11-RG-108

    • NAID

      130004463244

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590186
  • [Journal Article] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2012

    • Author(s)
      Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
    • Journal Title

      Eur J Clin Pharmacol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Journal Article] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2011

    • Author(s)
      Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, Kawakami J
    • Journal Title

      J Clin Pharmacol

      Volume: 51 Pages: 1529-1538

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん病態時における血中ナルデメジン濃度に及ぼすCYP3A5およびABCB1の遺伝子多型と悪液質進行の影響2023

    • Author(s)
      中津川瑛美、内藤隆文、柴田海斗、前川真人、川上純一
    • Organizer
      第143回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-21K06664
  • [Presentation] がん病態時における血中ナルデメジン濃度と排便効果に及ぼす遺伝子多型と悪液質進行の影響2023

    • Author(s)
      中津川瑛美, 内藤隆文, 柴田海斗, 前川真人, 川上純一
    • Organizer
      第33回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-21K06664
  • [Presentation] メタルフリーPEEKカラムを用いたOATP1B基質胆汁酸硫酸抱合体のLC-MS/MS同時定量法の開発2021

    • Author(s)
      黒澤優子, 内藤隆文, 前川真人, 伊東宏晃, 川上純一
    • Organizer
      第42回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07175
  • [Presentation] 頭頸部がん患者におけるトラマドール及び代謝物の光学異性体の血中動態とCYP2D6のactivity scoreとの関係解析.2020

    • Author(s)
      鈴木光路, 内藤隆文, 田中達也, 山田康秀, 伊藤邦彦, 川上純一.
    • Organizer
      第140回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-17K08410
  • [Presentation] デュロキセチン服用妊婦における臍帯血・母体血中薬物濃度と新生児薬物離脱症候群との関係2020

    • Author(s)
      田口怜奈, 内藤隆文, 鈴木光路, 伊東宏晃, 川上純一
    • Organizer
      第30回日本医療薬学会年会
    • Data Source
      KAKENHI-PROJECT-18K06746
  • [Presentation] An enantiomeric quantitation of tramadol and its metabolites in human plasma and evaluation of cytochrome P450-mediated stereoselective demethylation.2019

    • Author(s)
      Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
    • Organizer
      The 120th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08410
  • [Presentation] がん患者におけるトラマドールとその脱メチル代謝物の血中動態に及ぼすCYP2D6およびCYP2B6の遺伝子変異の影響2017

    • Author(s)
      田中達也, 内藤隆文, 佐藤聖, 川上純一
    • Organizer
      第38回日本臨床薬理学会年会
    • Data Source
      KAKENHI-PROJECT-15K08070
  • [Presentation] Impact of CYP2D6 phenotype on tramadol pharmacokinetics and metabolic pathways in cancer patients2017

    • Author(s)
      Tanaka H, Naito T, Sato H, Kawakami J
    • Organizer
      13th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08070
  • [Presentation] がん悪液質の病態時における血清IL-6 の濃度上昇とオキシコドンの血中動態および中枢症状発現との関係2016

    • Author(s)
      佐藤聖, 内藤隆文, 石田卓矢, 川上純一.
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-26460194
  • [Presentation] Impact of serum albumin level on free oxycodone pharmacokinetics, dose escalation, and central adverse reaction in cancer patients2011

    • Author(s)
      Naito T, Tashiro M, Yamamoto K, Kagawa Y, Kawakami J
    • Organizer
      10th Congress of the European Association for Clinical Pharmacology and Therapeutics
    • Place of Presentation
      Budapest, Hungary
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2011

    • Author(s)
      Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
    • Organizer
      第5回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011

    • Author(s)
      内藤隆文, 田代将貴, 山本圭祐, 賀川義之, 川上純一
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松市
    • Year and Date
      2011-12-02
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011

    • Author(s)
      内藤隆文,田代将貴,山本圭祐,賀川義之,川上純一
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] Impact of CYP2D6and CYP3A5gene polymorphisms on pharmacokinetics of oxycodone and its demethylates and dose escalation rate in cancer patients2010

    • Author(s)
      Naito T, Yamamoto K, Takashina Y, Tashiro M, Kagawa Y, Ohnishi K, Kawakami J
    • Organizer
      16th World Congress of Basic and Clinical Pharmacology(WorldPharma2010)
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6, CYP3A5, ABCB1およびOPRM1の遺伝子変異の影響-2010

    • Author(s)
      田代将貴,内藤隆文,山本圭祐,高科嘉章,賀川義之,川上純一
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2010

    • Author(s)
      Takashina Y, Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6、CYP3A5、ABCB1およびOPRM1の遺伝子変異の影響-2010

    • Author(s)
      内藤隆文, 川上純一, ら
    • Organizer
      日本薬学会年会
    • Place of Presentation
      岡山コンベンションセンター (岡山)
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21590155
  • [Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5, CYP2D6およびOPRM1の遺伝子変異の影響2009

    • Author(s)
      山本圭祐,内藤隆文,高科嘉章,丸山修治,賀川義之,川上純一
    • Organizer
      第30回日本臨床薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21590155
  • 1.  NAITO Takafumi (80422749)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 22 results
  • 2.  YAGI Tatsuya (70719575)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  HORI KATSUHITO (20436786)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TANAKA Hironari
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  ISHIDA Takuya
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  SAI KIMIE (20195960)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Imatoh Takuya (20368989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  見野 靖晃 (40586715)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  玉原 亨 (40756235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  小原 拓 (80612019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SATO Hikaru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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