Motoyama Noboru 本山昇

… Alternative Names

Noboru Motoyama 本山昇

MOTOYAMA NOBORU 本山昇

MOTOYAMA Noboru 本山昇

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Researcher Number	50277282
Other IDs
Affiliation (Current)	2025: 椙山女学園大学, 生活科学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 椙山女学園大学, 生活科学部, 教授 2016 – 2018: 椙山女学園大学, 生活科学部, 教授 2012 – 2014: 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 室長 2003 – 2006: 国立長寿医療センター, 研究所・老年病研究部, 室長 2004: National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Department of Geriatric Research, Section Chief, (研究所)・老年病研究部, 室長 … More 2001: 国立療養所中部病院(長寿医療研究センター), 老年病研究部, 室長 2000 – 2001: 国立長寿医療研究センター, 老年病研究部, 室長 1999: 九大, 生体防御医学研究所, 助教授 1997 – 1998: 九州大学, 生体防御医学研究所, 助教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 59040:Nutrition science and health science-related / Eating habits / Molecular biology / Immunology / General medical chemistry / Nerve anatomy/Neuropathology Except Principal Investigator Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Experimental pathology
Keywords	Principal Investigator p53 / Chk2 / アポトーシス / 老化 / SASP / SIRT1 / 細胞老化 / 細胞死 / 老年病 / 炎症性サイトカイン … More / 食品 / 炎症 / FOXO / apoptosis / アセチル化 / ミトコンドリア / DNA損傷 / リン酸化 / 転写 / 細胞周期チェックポイント / ノックアウトマウス / 胚性がん細胞 / X-linked IAP / IAPファミリー / TNFレセプター / シグナル伝達 / 健康寿命 / oxidative stress / DNA damage / Aging / DNA傷害 / 酸化ストレス / DNA傷 / antigen receptor / antibody / mitochondria / caspase / lymphocyte / knockout mouse / B cell / 抗原受容体 / 抗体 / カスパーゼ / リンパ球 / B細胞 / p21 / クロマチン / 細胞周期制御因子 / エピジェネティクス / HistoneH1.2 / がん抑制 / がん化 / ゲノム / Mdm2 / ATM / Chk1 / がん抑制遺伝子 / 放射線 … More Except Principal Investigator JC virus / siRNA / Agnoprotein / Apaf1 / 感染抑制 / agnoprotein / Agnoprotein(Agno) / JC Virus / mitochondria / apoptosis / neuron / Bcl-xL / Apafl / ミトコンドリア / アポトーシス / ニューロン / 転写調節因子 / 脳内接種 / 感染モデルマウス / ヌードマウス / Jc virus Less

Identificaiton of nutritional factors which suppresses SASPPrincipal Investigator
- Principal Investigator
  
  Noboru Motoyama
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Sugiyama Jogakuen University
Identificaiton of nutritional factors which suppress SASPPrincipal Investigator
- Principal Investigator
  
  MOTOYAMA NOBORU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Sugiyama Jogakuen University
Role of SIRT1 on regulation of senescence-associated secretory phenotype during senescencePrincipal Investigator
- Principal Investigator
  
  MOTOYAMA NOBORU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Chk2によるp53活性制御とがん抑制メカニズムに関する研究Principal Investigator
- Principal Investigator
  
  本山昇
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences,NCGG
Chk2によるがん抑制遺伝子産物p53の活性制御メカニズムの解析Principal Investigator
- Principal Investigator
  
  本山昇
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences,NCGG
進行性多巣性白質脳症のモデル動物の作製
- Principal Investigator
  
  SAWA Hirofumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
Development of therapeutic approach for progressive multifocal leukoencephalopathy using siRNA against JCV Agnogene.
- Principal Investigator
  
  SAWA Hirofumi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hokkaido University
DNA damage checkpoint mechanism and its relation to agingPrincipal Investigator
- Principal Investigator
  
  MOTOYAMA Noboru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology
発がんにおけるDNA傷害と細胞周期チェックポイントの分子機構に関する研究Principal Investigator
- Principal Investigator
  
  本山昇
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Longevity Sciences,NCGG
Analyses of regulatory mechanisms of apoptosis during the development of nervous system
- Principal Investigator
  
  YOSHIDA Hiroki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  KYUSHU UNIVERSITY
神経細胞の分化過程におけるアポトーシスの制御メカニズムの解析Principal Investigator
- Principal Investigator
  
  本山昇
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyushu University
TNF受容体ファミリーの情報伝達分子LAPファミリーによるアポトーシス制御機構Principal Investigator
- Principal Investigator
  
  本山昇
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Regulation of activation and apoptosis during B cell differentiationPrincipal Investigator
- Principal Investigator
  
  MOTOYAMA Noboru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY

All 2021 2020 2018 2017 2015 2014 2013 2012 2005 2004 Other

All Journal Article Presentation Book

[Book] 老化の分子生物学、その分子メカニズムから寿命延長まで2014
- Author(s)
  本山　昇
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-24590369
[Book] 「DNA複製およびダメージチェックポイント」キーワードで理解する細胞周期イラストマップ2005
- Author(s)
  仲一仁, 本山昇
- Total Pages
  189
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16022267
[Book] 「DNA複製およびダメージチェックポイント」キーワードで理解する細胞周期イラストマップ2005
- Author(s)
  仲一仁, 本山昇
- Total Pages
  189
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370080
[Journal Article] Differential roles of Rad18 and Chk2 in genome maintenance and skin carcinogenesis following UV exposure.2018
- Author(s)
  Tanoue, Y., Toyoda, T., Sun, J, Mustofa, M.K., Tateishi, C., Endo, S., Motoyama, N., Araki, K., Wu, D., Okuno, Y., Tsukamoto, T., Takeya, M., Ihn, H., Vaziri, C., Tateishi, S.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 12 Pages: 2550-2557
- DOI
  10.1016/j.jid.2018.05.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11646, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-16K00878, KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-16K10165, KAKENHI-PROJECT-18K08363, KAKENHI-PROJECT-16K15248
[Journal Article] 細胞の老化を標的とした健康寿命延長ー栄養学との接点ー2017
- Author(s)
  本山　昇
- Journal Title
  
  生活の科学
  
  Volume: 39 Pages: 17-20
- NAID
  120007117118
- Data Source
  KAKENHI-PROJECT-16K00878
[Journal Article] CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid2017
- Author(s)
  65.Choo DW, Goh SH, Cho YW, Baek HJ, Park EJ, Motoyama N, Kim TH, Kim JY, Kim SS.
- Journal Title
  
  Oncology Letter
  
  Volume: 13 Issue: 4 Pages: 2591-2598
- DOI
  10.3892/ol.2017.5792
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00878
[Journal Article] SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.2015
- Author(s)
  Hayakawa T, Iwai M, Aoki S, Takimoto K, Maruyama M, Maruyama W, Motoyama N.
- Journal Title
  
  PLoS One.
  
  Volume: 10(1) Issue: 1 Pages: e0116480-e0116480
- DOI
  10.1371/journal.pone.0116480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248024, KAKENHI-PROJECT-24590369
[Journal Article] Necessary and sufficient role for a mitosis skip in senescence induction.2014
- Author(s)
  Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M.
- Journal Title
  
  Mol.Cell
  
  Volume: 55 Issue: 1 Pages: 73-84
- DOI
  10.1016/j.molcel.2014.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24590369, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26860195
[Journal Article] Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress2012
- Author(s)
  Lee, I.H., Kawai, Y., Fergusson, M.M., Rovira, I.I., Bishop, A.J., Motoyama, N., Cao, L., and Finkel, T
- Journal Title
  
  Science
  
  Volume: 336 Issue: 6078 Pages: 225-228
- DOI
  10.1126/science.1218395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658118, KAKENHI-PROJECT-24590369
[Journal Article] Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.2012
- Author(s)
  Demidov ON, Zhu Y, Kek C, Goloudina AR, Motoyama N, Bulavin DV
- Journal Title
  
  Cell Death Differ
  
  Volume: 19 Issue: 11 Pages: 1761-1768
- DOI
  10.1038/cdd.2012.57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590369
[Journal Article] DNA damage tumor suppressor genes and genomic instability.2004
- Author(s)
  Motoyama N, Naka K
- Journal Title
  
  Curr.Opin.Genet.Dev. 14
  
  Pages: 11-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370080
[Journal Article] DNA damage tumor suppressor genes and genomic instability.2004
- Author(s)
  Motoyama N, Naka K.
- Journal Title
  
  Curr.Opin.Genet.Dev. 14
  
  Pages: 11-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370080
[Journal Article] DNA damage tumor suppressor genes and genomic instability2004
- Author(s)
  Motoyama N, Naka K
- Journal Title
  
  Cur.Opin.Genet.Dev. 14
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-16022267
[Presentation] 細胞老化と個体老化を結ぶ鍵となるSASP2021
- Author(s)
  本山昇
- Organizer
  日本基礎老化学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K11634
[Presentation] 細胞老化から個体老化へ ―歴史と展望―2020
- Author(s)
  本山昇
- Organizer
  日本基礎老化学会市民フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K11634
[Presentation] SIRT1 regulates the expression of p21 during cellular senescence2018
- Author(s)
  33.Hayakawa T. Morimoto R, Kimura Y, Nagasaki M, Nagata M, Maruyama M, Motoyama N
- Organizer
  Aging and Metabolism, Cell Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00878
[Presentation] p21 negatively regulates DNA damage-induced pro-inflammatory response during senescence2018
- Author(s)
  32.Hayakawa T, Kimura Y, Nagasaki M, Nagata M, Morimoto R, Maruyama M, Motoyama N
- Organizer
  “Aging, Inflammation and Immunity”, Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00878
[Presentation] がん化と老化を制御する細胞老化とＳＡＳＰ2017
- Author(s)
  本山　昇
- Organizer
  第40回日本基礎老化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K00878
[Presentation] SIRT1 epigenetically regulates DNA damagae-initiated pro-inflammatory response.2014
- Author(s)
  Motoyama N, Hayakawa T, Iwai M, Aoki S, Maruyama W
- Organizer
  Molecular Biology of Aging, Cold Spring Harbor Laboratory Meeting
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-24590369
[Presentation] SIRT1によるヒストン脱アセチル化を介したSASPのエピジェネティックな制御機構．2013
- Author(s)
  早川智久、岩井美佳、青木哲、丸山和佳子、本山　昇．
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590369
[Presentation] SIRT1 regulates DNA damage-mediated pro-inflammatory response.2013
- Author(s)
  Hayakawa T, Iwai M, Aoki S, Maruyama W, Motoyama N.
- Organizer
  The 7th Symposium Mechanisms and Models of Cancer
- Place of Presentation
  La Jolla, USA
- Data Source
  KAKENHI-PROJECT-24590369
[Presentation] DNA損傷応答機構（DDR）による老化・がん化の制御
- Author(s)
  本山　昇
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  福岡市
- Invited
- Data Source
  KAKENHI-PROJECT-24590369
[Presentation] SIRT1 epigenetically regulates senescence-associated secretory phenotype during cellular senescence.
- Author(s)
  Hayakawa T, Iwai M, Aoki S, Maruyama W, Motoyama N
- Organizer
  第37回日本基礎老化学会大会
- Place of Presentation
  大府市、愛知県
- Year and Date
  2014-06-26 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24590369

1. SAWA Hirofumi (30292006)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. YOSHIDA Hiroki (40260715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAHASHI Hidehiro (70260271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 渡邊武 (40028684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 池田恭治 (00222878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 河合慶親

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 丸山和佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 立石智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中西真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Motoyama Noboru 本山 昇

Noboru Motoyama 本山 昇

MOTOYAMA NOBORU 本山 昇

MOTOYAMA Noboru 本山 昇

Research Projects

Research Products

Co-Researchers

Identificaiton of nutritional factors which suppresses SASPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identificaiton of nutritional factors which suppress SASPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of SIRT1 on regulation of senescence-associated secretory phenotype during senescencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chk2によるp53活性制御とがん抑制メカニズムに関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chk2によるがん抑制遺伝子産物p53の活性制御メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

進行性多巣性白質脳症のモデル動物の作製

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of therapeutic approach for progressive multifocal leukoencephalopathy using siRNA against JCV Agnogene.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA damage checkpoint mechanism and its relation to agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発がんにおけるDNA傷害と細胞周期チェックポイントの分子機構に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of regulatory mechanisms of apoptosis during the development of nervous system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経細胞の分化過程におけるアポトーシスの制御メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TNF受容体ファミリーの情報伝達分子LAPファミリーによるアポトーシス制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Regulation of activation and apoptosis during B cell differentiationPrincipal Investigator

Principal Investigator

Motoyama Noboru 本山昇

Noboru Motoyama 本山昇

MOTOYAMA NOBORU 本山昇

MOTOYAMA Noboru 本山昇