TAKAHASHI Hidehiro 高橋秀宗

… Alternative Names

高橋秀宗タカハシヒデヒロ

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Researcher Number	70260271
Other IDs
Affiliation (based on the past Project Information) *help	2003 – 2006: 国立感染症研究所, 感染病理部, 室長 2000: 国立感染症研究所, 感染病理部, 室長 1997 – 1999: 国立感染症研究所, 主任研究官 1997 – 1999: 国立感染症研究所, 感染病理部, 主任研究官 1996: 国立予防衛生研究所, 感染病病理部, 研究員 1994 – 1996: 国立予防衛生研究所, 感染病理部, 研究員
Review Section/Research Field	Principal Investigator Experimental pathology / Biological Sciences Except Principal Investigator Biological pharmacy / Biological Sciences / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 逆転写 / ウイルスと宿主の相互作用 / HIV-1の複製機構 / ウイルス複製の宿主因子 / トポイソメラーゼ I / トポイソメラーゼI / ATP結合因子 / RNAの安定性 / topoisomerase I / HIV-1 … More / Topoisomerase I活性化 / HIV-1初期複製 / ウイルス宿主相互作用 / レトロウイルスの複製 / トポイソメラーゼ 1 / レトロウイルス / トポイソメラーセI / C23 … More Except Principal Investigator HIV / Nef / HIV-1 / Agnoprotein / siRNA / JC virus / 麝香水抽出画分 / 抗-HIV作用 / 感染細胞死滅阻止 / Hck / Src / チロシンキナーゼ / エイズ / CD4陽性T細胞 / NF-κB / ケモカインレセプター / レトロウイルス / インテグレーション / 核外移行 / ゲノム / TAT / インテグレース / REV / 核内因子 / gp41 / 阻害剤 / RANTES / サル細胞 / SIV / SDFA / CD26 / 糖鎖 / 逆転写 / アクセサリー蛋白 / サブタイプEゲノム / AIDS / CD4(+) T cell / NF-kappaB / Chemokine receptor / Retrovirus / Integration / Nuclear export / JC Virus / Agnoprotein(Agno) / agnoprotein / 感染抑制 Less

Development of therapeutic approach for progressive multifocal leukoencephalopathy using siRNA against JCV Agnogene.
- Principal Investigator
  
  SAWA Hirofumi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hokkaido University
サル細胞によるHIV-1初期複製機構の解析Principal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
レトロウイルス逆転写におけるtopoisomerase Iの作用機序の解析Principal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  National Institute of Infectious Diseases
Basic Research for AIDS control A01 ; Host factors necessary for HIV-1 replication
- Principal Investigator
  
  KOYANAGI Yoshio, 永井美之
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  TOHOKU UNIVERSITY
  The University of Tokyo
HIV-1複製に関わる新たな宿主因子の解明Principal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
チロシンキナーゼおよびG蛋白によるHIV感染性の制御機構
- Principal Investigator
  
  松田道行
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute, International Medical Center of Japan
レトロウイルスの複製に関与する宿主因子の解析Principal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  National Institute of Infectious Diseases
HIV-1複製におけるトポイソメラーゼIのはたらきPrincipal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
HIV-1,gag蛋白依存性に活性化される宿主トポイソメラーゼIのはたらきPrincipal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  国立予防衛生研究所
HIV-1複製におけるトポイソメラーゼIのはたらきPrincipal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
HIV-1,gag蛋白依存性に活性化される宿主トポイソメラーゼIのはたらきPrincipal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  国立予防衛生研究所
麝香水抽出画分の抗-HIV作用の解析
- Principal Investigator
  
  小島朝人
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  国立予防衛生研究所
HIV-1の初期複製におけるトポイソメラーゼ活性の関与Principal Investigator
- Principal Investigator
  
  高橋秀宗
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  国立予防衛生研究所

All 2006 2005 2004 2003

All Journal Article Patent

[Journal Article] Dicer and positive charge of proteins decrease the stability of RNA containing the AU-rich element of GM-CSF.2006
- Author(s)
  Takahashi H, Maeda M, Sawa H, Hasegawa H, Moriyama M, Sata T, Hall WW, Kurata T
- Journal Title
  
  Biochem Biophys Res Commun 340
  
  Pages: 807-814
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Development of Thymus-Derived T-cell Leukemia/Lymphoma in Mice Transgenic for the Tax gene of Human T-Lymphotropic Virus Type-I (HTLV-I).2006
- Author(s)
  Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sherhy N, Yamamoto Y, Ichinohe T, Tsunetsugu-Yokota Y, Katano H, Takahashi H, Matsuda J, Sata T, Kurata T, Nagashima, K, Hall, WW
- Journal Title
  
  Nat Med 12
  
  Pages: 466-472
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant.2006
- Author(s)
  Ichinohe T, Watanabe I, Tao E, Ito S, Kawaguchi A, Tamura SI, Takahashi H, Sawa H, Moriyama M, Chiba J, Komase K, Suzuki Y, Kurata T, Sata T, Hasegawa H
- Journal Title
  
  J Med Virol 78
  
  Pages: 954-963
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Intranasal administration of adjuvant-combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection.2006
- Author(s)
  Asahi-Ozaki Y, Itamura S, Ichinohe T, Strong P, Tamura S, Takahashi H, Sawa H, Moriyama M, Tashiro M, Sata T, Kurata T, Hasegawa H
- Journal Title
  
  Microbes Infect 8
  
  Pages: 2706-2714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SM-P) as an adjuvant.2006
- Author(s)
  Ichinohe T, Watanabe I, Tao E, Ito S, Kawaguchi A, Tamura SI, Takahashi H, Sawa H, Moriyama M, Chiba J, Komase K, Suzuki Y, Kurata T, Sata T, Hasegawa H
- Journal Title
  
  J Med Virol 78
  
  Pages: 954-963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type-I.2006
- Author(s)
  Hasegawa H^*, Sawa H^*, Lewis MJ, Orba Y, Sherhy N, Yamamoto Y, Ichinohe T, Tsunetsugu-Yokota Y, Katano H, Takahashi H, Matsuda J, Sata T, Kurata T, Nagashima, K, Hall, WW
- Journal Title
  
  Nat Med 12
  
  Pages: 466-472
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Development of Thymus-Derived T-cell Leukemia/Lymphoma in Mice Transgenic for the Tax gene of Human T-Lymphotropic Virus Type-I (HTLV-I). (*These authors contributed equally to this work.)2006
- Author(s)
  Hasegawa H*, Sawa H*, Lewis MJ, Orba Y, Sherhy N, Yamamoto Y, Ichinohe T, Tsunetsugu-Yokota Y, Katano H, Takahashi H, Matsuda J, Sata T, Kurata T, Nagashima, K, Hall, WW.
- Journal Title
  
  Nat Med 12
  
  Pages: 466-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Tristetraprolin inhibits HIV-1 production by binding to genomic RNA.2006
- Author(s)
  Maeda M, Sawa H, Tobiume M, Tokunaga K, Hasegawa H, Ichinohe T, Sata T, Moriyama M, Hall WW, Kurata T, Takahashi T
- Journal Title
  
  Microbes Infect 8
  
  Pages: 2647-2656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal administration of HA vaccine with chitin microparticles as an adjuvant.2005
- Author(s)
  Hasegawa H, Ichinohe T, Strong P, Watanabe I, Ito S, Tamura S-i, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T
- Journal Title
  
  J Med Virol 75
  
  Pages: 130-136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein : role in nuclear egress of viral particles.2005
- Author(s)
  Okada Y, Suzuki T, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H^*
- Journal Title
  
  EMBO Rep 6
  
  Pages: 452-457
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal administration of HA vaccine with chitin microparticles as an adiuvant.2005
- Author(s)
  Hasegawa H, Ichinohe T, Strong P, Watanabe I, Ito S, Tamura S-i, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T
- Journal Title
  
  JMed Virol 75
  
  Pages: 130-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Synthetic double-stranded RNA [poly (I : C)] combined with mucosal vaccine protects against influenza virus infection.2005
- Author(s)
  Ichinohe T, Watanabe I, Ito S, Moriyama M, Tamura S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T, Hasegawa H
- Journal Title
  
  J Virol 79
  
  Pages: 2910-2919
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein : role in nuclear egress of viral particles.2005
- Author(s)
  Okada Y, Suzuki T, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H*
- Journal Title
  
  EMBO Rep 6
  
  Pages: 452-457
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Synthetic double-stranded RNA [poly (I:C)] combined with mucosal vaccine protects against influenza virus infection.2005
- Author(s)
  Ichinohe T, Watanabe I, Ito S, Moriyama M, Tamura S, Takahashi H, Sawa H, et al.
- Journal Title
  
  J Virol 79
  
  Pages: 2910-2919
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Synthetic double-stranded RNA [poly (I:C)] combined with mucosal vaccine protects against influenza virus infection.2005
- Author(s)
  Ichinohe T, Watanabe I, Ito S, Moriyama M, Tamura S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T, Hasegawa H
- Journal Title
  
  J Virol 79
  
  Pages: 2910-2919
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein : role in nuclear egress of viral particles. (* corresponding author)2005
- Author(s)
  Okada Y, Suzuki T, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H*
- Journal Title
  
  EMBO Rep 6
  
  Pages: 452-457
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Tbpoisomerase I dissociates human immunodeficiency virus type 1 reverse transcriptase from genomic RNAs.2004
- Author(s)
  Takahashi H, Sawa H, Hasegawa H, Nagashima K, Sata T, Kurata T
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 1073-1078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Topoisomerase I dissociates human immunodeficiency virus type 1 reverse transcriptase from genomic RNAs.2004
- Author(s)
  Takahashi H, Sawa H, Hasegawa H, Nagashima K, Sata T, Kurata T
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 1073-1078
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Nucleolin and the packaging signal, Ψ promote the budding of human immunodeficiency virus type-1 (HIV-1).2004
- Author(s)
  Ueno T, Tokunaga K, Sawa H, Maeda M, Chiba J, Kojima A, Hasegawa H, Shoya Y, Sata T, Kutrata T, Takahashi H
- Journal Title
  
  Microbiol Immunol 48
  
  Pages: 111-118
- NAID
  10012077192
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Nucleolin and the packaging signal, ψ promote the budding of human immunodeficiency virus type-1 (HIV-1).2004
- Author(s)
  Ueno T, Tokunaga K, Sawa H, Maeda M, Chiba J, Kojima A, Hasegawa H, Shoya Y, Sata T, Kutrata T, Takahashi H
- Journal Title
  
  Microbiol Immunol 48
  
  Pages: 111-118
- NAID
  10012077192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Topoisomerase I dissociates human immunodeficiency virus type I reverse transcriptase from genomic RNAs.2004
- Author(s)
  Takahashi H, Sawa H, et al.
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 1073-1078
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal administration of H A vaccine with chitin microparticles as an adjuvant.2004
- Author(s)
  Hasegawa H, Ichinohe T, Strong P, Watanabe I, Ito S, Tamura S-i, Takahashi H, Sawa H et al.
- Journal Title
  
  J Med Virol 75
  
  Pages: 130-136
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Human topoisomerase I promotes HIV-1 proviral DNA synthesis : implications for the species specificity and cellular tropism of HIV-1 infection.2003
- Author(s)
  Shoya Y, Tokunaga T, Sawa H, Maeda M, Ueno T, Yoshikawa T, Sata T, Kurata T, Hall WW, Cullen BR, Takahashi H
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 8442-8447
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Human topoisomerase I promotes HIV-1 proviral DNA synthesis : implications for the species specificity and cellular tropism of HIV-1 infection.q2003
- Author(s)
  Shoya Y, Tokunaga T, Sawa H, Maeda M, Ueno T, Yoshikawa T, Sata T, Kurata T, Hall WW, Cullen BR, Takahashi H
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 8442-8447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Journal Article] Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutinin.2003
- Author(s)
  Watanabe I, Ross TM, Tamura Si, Ichinohe T, Ito S, Takahashi H, Sawa H, Chiba J, Kurata T, Sata T, Hasegawa H
- Journal Title
  
  Vaccine 21
  
  Pages: 4532-4538
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112
[Patent] HIV-I複製抑制剤2004
- Inventor(s)
  長嶋和郎, 澤洋文, 高橋秀宗
- Industrial Property Rights Holder
  科学技術振興機構, 国立感染症研究所
- Industrial Property Number
  2004-061237
- Filing Date
  2004-03-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300112

1. 長嶋和郎 (50010377)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 倉田毅 (50012779)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KOYANAGI Yoshio (80215417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MASUDA Takao (80219336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. OKAMOTO Takashi (40146600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIODA Tatsuo (00187329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIDA Hisatoshi (00144395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAWA Hirofumi (30292006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
9. MOTOYAMA Noboru (50277282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小島朝人 (30100077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松田道行 (10199812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 永井美之 (20022874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 足立昭夫 (90127043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 生田和良 (60127181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 庄谷祐子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Hidehiro 高橋 秀宗

高橋 秀宗 タカハシ ヒデヒロ

Research Projects

Research Products

Co-Researchers

Development of therapeutic approach for progressive multifocal leukoencephalopathy using siRNA against JCV Agnogene.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サル細胞によるHIV-1初期複製機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

レトロウイルス逆転写におけるtopoisomerase Iの作用機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic Research for AIDS control A01 ; Host factors necessary for HIV-1 replication

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HIV-1複製に関わる新たな宿主因子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

チロシンキナーゼおよびG蛋白によるHIV感染性の制御機構

Principal Investigator

Project Period (FY)

Research Category

Research Institution

レトロウイルスの複製に関与する宿主因子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIV-1複製におけるトポイソメラーゼIのはたらきPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

HIV-1,gag蛋白依存性に活性化される宿主トポイソメラーゼIのはたらきPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIV-1複製におけるトポイソメラーゼIのはたらきPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

HIV-1,gag蛋白依存性に活性化される宿主トポイソメラーゼIのはたらきPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

麝香水抽出画分の抗-HIV作用の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIV-1の初期複製におけるトポイソメラーゼ活性の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dicer and positive charge of proteins decrease the stability of RNA containing the AU-rich element of GM-CSF.2006

TAKAHASHI Hidehiro 高橋秀宗

高橋秀宗タカハシヒデヒロ