Yamaguchi Yoshihide 山口宜秀

… Alternative Names

山口宜秀ヤマグチヨシヒデ

YAMAGUCHI Yoshihide 山口宜秀

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Researcher Number	50311832
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 東京薬科大学, 薬学部, 准教授 2014: 東京薬科大学, 薬学部, 准教授 2007: 東京薬科大学, 薬学部, 准教授 2001 – 2006: 東京薬科大学, 薬学部, 講師 2000: 高知医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neuroscience in general Except Principal Investigator Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 翻訳 / リードスルー / PKC / 細胞接着 / ミエリン / 脳・神経 / シャルコー・マリー・トゥース病 / タンパク質キナーゼＣ / リン酸化 / 髄鞘 … More / 翻訳リードスルー / in situ hybridization / エストロゲン受容体 / 2次元電気泳動 / プロテオミクス / 胎仔脳 / 性差 … More Except Principal Investigator ミエリン / 電位依存性カリウムチャネル / 有髄神経 / スルファチド / 電位依存性ナトリウムチャネル / ランビエ絞輪 / シュワン細胞 / オリゴデンドロサイト / shcwann cell / oligodendrocyte / sulfatide / myelinated nerve fiber / myelin / the nodes of Ranvier / voltage-gated potassium channel / voltage-gated sodium channel / サルファチド / 脳・神経 / 翻訳 / 神経科学 / PKC / リン酸化 / 細胞接着 / リードスルー / 2次元電気泳動法 / アストロサイト / FISH / PCR / 染色体 / ペインティングプローブ / 固形腫瘍 / CGH Less

Elucidation of the mechanism and physiological significance of translational readthrough in higher animals nervous systemPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Yoshihide
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Production mechanism and functional role of myelin protein produced by stop codon readthrough
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
グリアによる神経軸索上機能分子の発現および局在化調節機構の解明
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on molecular mechanisms of ion channel clustering at the nodes of Ranvier.
- Principal Investigator
  
  BABA Hiroko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
胎生期脳に発現する性特異的遺伝子の解析Principal Investigator
- Principal Investigator
  
  山口宜秀
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo University of Pharmacy and Life Science
CGH法で検出された高度増幅遺伝子部位からの特異的ペインティングプローブの開発
- Principal Investigator
  
  田口尚弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  高知医科大学

All 2022 2021 2020 2019 2012 2007 Other

All Journal Article Presentation

[Journal Article] Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system2022
- Author(s)
  Yoshinori Otani, Akihiro Taguchi , Keisuke Hamada, Yoshio Hayashi, Yoshihide Yamaguchi, Hiroko Baba
- Journal Title
  
  Neuropharmacology
  
  Volume: 211 Pages: 109059-109059
- DOI
  10.1016/j.neuropharm.2022.109059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19H03356
[Journal Article] Upregulation of large myelin protein zero leads to CharcotーMarieーTooth disease-like neuropathy in mice2020
- Author(s)
  Otani Yoshinori、Ohno Nobuhiko、Cui Jingjing、Yamaguchi Yoshihide、Baba Hiroko
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 121-121
- DOI
  10.1038/s42003-020-0854-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19K16267, KAKENHI-PROJECT-16H06280
[Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.2012
- Author(s)
  Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 287 Issue: 21 Pages: 17765-17776
- DOI
  10.1074/jbc.m111.314468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591239, KAKENHI-PROJECT-24500449, KAKENHI-PROJECT-24591256
[Journal Article] Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects.2007
- Author(s)
  Yoshihide Yamaguchi, et. al.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 766-775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15082208
[Journal Article] Two-dimensional electrophoresis with cationic detergents, a powerful tool for the proteomic analysis of myelin proteins. Part 1: technical aspects of electrophoresis.2007
- Author(s)
  Yoshihide Yamaguchi, et. al.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 755-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] 末梢神経ミエリンタンパク質L-MPZを欠損したマウスの解析2022
- Author(s)
  瀬戸口　潔、林　明子、崔　晶晶、林　萌々花、平井　大之、雨宮　千紗、大谷　嘉典、馬場　広子、山口　宜秀
- Organizer
  第6回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] L-MPZの機能とリン酸化による制御機構の解明2022
- Author(s)
  後藤　雅裕、渡邊　佑奈、中島　鉄博、大谷　嘉典、馬場　広子、山口　宜秀
- Organizer
  第6回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] L-MPZ PKCリン酸化サイト変異マウスの作製2022
- Author(s)
  小倉　新、後藤　雅裕、山口　宜秀
- Organizer
  第6回日本ミエリン研究会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] P0タンパク質翻訳リードスルーの異常増加で誘導されるCMT病態の解析2022
- Author(s)
  山口　宜秀
- Organizer
  第6回日本ミエリン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] ミエリンタンパク質L-MPZは末梢神経系の構造維持と機能に必要である2021
- Author(s)
  瀬戸口　潔、大谷　嘉典、林　明子、崔　晶晶、平井　大之、雨宮　千紗、山口　宜秀、澤井摂、馬場　広子
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] 末梢ミエリンタンパク質L-MPZのPKCリン酸化による細胞接着活性の解析2021
- Author(s)
  後藤　雅裕、渡邊　佑奈、中島　鉄博、大谷　嘉典、馬場　広子、山口　宜秀
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系におけるミエリン形成・維持に重要である2020
- Author(s)
  後藤雅裕，崔晶晶，瀬戸口潔，林萌々花，平井大之，大谷嘉典，山口宜秀，馬場広子
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] シャルコー・マリー・トゥース病モデルマウス:L-MPZマウスの病態進行の解析2020
- Author(s)
  大谷嘉典，崔晶晶，山口宜秀，藍郷加奈子，原綾香、坂剛太、藤谷昌司，馬場広子
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] シャルコー・マリー・トゥース病モデル L-MPZ マウスにおけるミエリン形成過程の解析2019
- Author(s)
  山口宜秀、大谷　嘉典、竹原　雅之、中島　鉄博、楢崎　琢朗、崔　晶晶、馬場　広子
- Organizer
  NEURO 2019 第42回日本神経科学大会　第62回日本神経化学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Abnormalities of Peripheral Mmyelin Development in CharcotーMarieーTooth (CMT) Disease model, L-MPZ mouse.2019
- Author(s)
  Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
- Organizer
  2019 ISN-ASN Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Excessive Production of L-MPZ, a Translational Readthrough Isoform of Myelin Protein Zero (P0, MPZ), Causes CharcotーMarieーTooth Disease (CMT)-like Phenotype.2019
- Author(s)
  Y. Yamaguchi, Y. Otani, M. Takehara, T. Nakajima, T. Narazaki, J. Cui, H. Baba
- Organizer
  The 14th Biennial ISN Satellite Meeting on Myelin Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Translational Readthrough Regulates Physiological Function in the Nervous System2019
- Author(s)
  Y. Yamaguchi, Y. Otani, N. Ohno, J. Cui, H. Baba
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06889
[Presentation] Analysis of stop codon readthrough mechanism for production of L-MPZ2012
- Author(s)
  Yoshihide Yamaguchi 他
- Organizer
  The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24500449
[Presentation] 難治性白質変性疾患治療を目的とした脱髄および髄鞘再生メカニズムの解明2007
- Author(s)
  山口宜秀, ら
- Organizer
  第1回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] Analysis of high molecular weight myelin proteins using 16-BAC/SDS-PAGE2007
- Author(s)
  山口宜秀, ら
- Organizer
  ISN and ANS, 21st Biennial meeting
- Place of Presentation
  Mexico
- Year and Date
  2007-08-19
- Data Source
  KAKENHI-PROJECT-15082208
[Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ
- Author(s)
  Yoshihide Yamaguchi et al
- Organizer
  25th Meeting of the International Society for Neurochemistry
- Place of Presentation
  ケアンズ、オーストラリア
- Year and Date
  2015-08-23 – 2015-08-27
- Data Source
  KAKENHI-PROJECT-24500449
[Presentation] Adhesion properties mediated by PKC-dependent phosphorylation are different between myelin P0 and its readthrough isoform L-MPZ
- Author(s)
  Yoshihide Yamaguchi et al
- Organizer
  12th Satellite Meeting on Myelin Biology 2015
- Place of Presentation
  フィッツロイ島、オーストラリア
- Year and Date
  2015-08-28 – 2015-08-31
- Data Source
  KAKENHI-PROJECT-24500449

1. BABA Hiroko (40271499)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. HAYASHI Akiko (90232090)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 田口尚弘 (80127943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 由利和成 (10220534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 石橋智子 (50453808)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKANISHI Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YANO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 木村暁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Yoshihide 山口 宜秀

山口 宜秀 ヤマグチ ヨシヒデ

YAMAGUCHI Yoshihide 山口 宜秀

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism and physiological significance of translational readthrough in higher animals nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Production mechanism and functional role of myelin protein produced by stop codon readthrough

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

グリアによる神経軸索上機能分子の発現および局在化調節機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular mechanisms of ion channel clustering at the nodes of Ranvier.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎生期脳に発現する性特異的遺伝子の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CGH法で検出された高度増幅遺伝子部位からの特異的ペインティングプローブの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of large myelin protein zero leads to CharcotーMarieーTooth disease-like neuropathy in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects.2007

Author(s)

Journal Title

Data Source

[Journal Article] Two-dimensional electrophoresis with cationic detergents, a powerful tool for the proteomic analysis of myelin proteins. Part 1: technical aspects of electrophoresis.2007

Author(s)

Journal Title

Data Source

[Presentation] 末梢神経ミエリンタンパク質L-MPZを欠損したマウスの解析2022

Author(s)

Organizer

Data Source

[Presentation] L-MPZの機能とリン酸化による制御機構の解明2022

Author(s)

Organizer

Data Source

[Presentation] L-MPZ PKCリン酸化サイト変異マウスの作製2022

Author(s)

Organizer

Data Source

[Presentation] P0タンパク質翻訳リードスルーの異常増加で誘導されるCMT病態の解析2022

Author(s)

Organizer

Yamaguchi Yoshihide 山口宜秀

山口宜秀ヤマグチヨシヒデ

YAMAGUCHI Yoshihide 山口宜秀

[Presentation] 翻訳リードスルー産物である L-MPZは末梢神経系におけるミエリン形成・維持に重要である2020