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Sekine Shunichi  関根 俊一

… Alternative Names

SEKINE Shunichi  関根 俊一

関根 俊一  セキネ シユンイチ

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Researcher Number 50321774
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8174-8704
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター
2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help 2018 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー
2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー
2013 – 2014: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー
2012: 独立行政法人理化学研究所, システム研究チーム, 上級研究員
2011: 東京大学, 大学院・理学系研究科, 講師 … More
2010 – 2011: 東京大学, 大学院・理学系研究科, 特任准教授
2008 – 2009: The University of Tokyo, 大学院・理学系研究科, 講師
2006: 東京大学, 大学院理学系研究科, 講師
2005: 東京大学, 大学院・理学系研究科, 講師
2003: 独立行政法人理化学研究所, 細胞情報伝達研究室, 研究員
2002: 理化学研究所, 細胞情報伝達研究室, 研究員 Less
Review Section/Research Field
Principal Investigator
Structural biochemistry / Broad Section G / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biophysics / Structural biochemistry
Except Principal Investigator
Transformative Research Areas, Section (III) / Structural biochemistry
Keywords
Principal Investigator
RNAポリメラーゼ / 転写因子 / クライオ電子顕微鏡 / ヌクレオソーム / 転写 / X線結晶構造解析 / リボソーム / クライオ電顕 / 構造機能相関 / 酵素 … More / バクテリオファージ / X線結晶構造解析 / Rho / 転写終結 / tRNA / クロマチン / ncRNA / 転写終結因子 / ヒストンシャペロン / 転写伸長因子 / 電子顕微鏡 / 構造解析 / Pol II / 転写伸長 / X線結晶構造解 / クロスリンク / 校正 / 翻訳伸長因子 / オパール / セレノリン酸 / 翻訳延長因子 / サプレッサー / 翻訳 / セレン / セレノシステイン / 立体構造 / X-ray crystallography / crystallization / aminoacyl-tRNA synthetase / aminoacylation … More
Except Principal Investigator
不均一光環境 / 環境応答 / 植物 / 転写開始点制御 / X線結晶構造解析 / 翻訳開始因子 / リボソーム / 翻訳 / 転写因子 / RNAポリメラーゼ / 転写 Less
  • Research Projects

    (10 results)
  • Research Products

    (91 results)
  • Co-Researchers

    (16 People)
  •  Structural basis of transcription in chromatinPrincipal Investigator

    • Principal Investigator
      関根 俊一
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section G
    • Research Institution
      Institute of Physical and Chemical Research
  •  植物の不均一環境変動へのレジリエンスを支える転写開始点制御機構

    • Principal Investigator
      松下 智直
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Kyoto University
  •  Structural basis of higher-order complexes connecting transcription and its related functionsPrincipal Investigator

    • Principal Investigator
      関根 俊一
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section G
    • Research Institution
      Institute of Physical and Chemical Research
  •  RNAポリメラーゼを中心に形成される中核的複合体の構造基盤Principal Investigator

    • Principal Investigator
      関根 俊一
    • Project Period (FY)
      2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Structural basis of RNA polymerase regulation by transcription factorsPrincipal Investigator

    • Principal Investigator
      Sekine Shun-ichi
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Structural and functional studies of multiple complexes of RNA polymerasePrincipal Investigator

    • Principal Investigator
      SEKINE Shun-ichi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research
      The University of Tokyo
  •  Crystallographic studies of macromolecular complexes in transcription and translation : RNA polymerases and the ribosome

    • Principal Investigator
      YOKOYAMA Shigeyuki
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Structural biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research
      The University of Tokyo
      Tokyo Gakugei University
  •  Structural biology of the selenocysteine synthesis system.Principal Investigator

    • Principal Investigator
      SEKINE Shun-ichi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  転写終結複合体のX線結晶構造解析Principal Investigator

    • Principal Investigator
      関根 俊一
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokyo
  •  ヒト由来グルタミルプロリルtRNA合成酵素のX線結晶構造解析Principal Investigator

    • Principal Investigator
      関根 俊一
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

  • [Book] RNA Polymerases as Molecular Motors: On the Road2021

    • Author(s)
      Sekine, S., Uejima, T., Ehara, H. (ed. Robert Landick, Terence Strick, Jue Wang)
    • Total Pages
      252
    • Publisher
      Royal Society of Chemistry
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Journal Article] Structural perspectives on transcription in chromatin2024

    • Author(s)
      Sekine Shun-ichi、Ehara Haruhiko、Kujirai Tomoya、Kurumizaka Hitoshi
    • Journal Title

      Trends in Cell Biology

      Volume: 34 Issue: 3 Pages: 211-224

    • DOI

      10.1016/j.tcb.2023.07.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475
  • [Journal Article] Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from <i>Thermus thermophilus</i>2023

    • Author(s)
      Murayama Yuko、Ehara Haruhiko、Aoki Mari、Goto Mie、Yokoyama Takeshi、Sekine Shun-ichi
    • Journal Title

      Science Advances

      Volume: 9 Issue: 6

    • DOI

      10.1126/sciadv.ade7093

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-17K15082
  • [Journal Article] Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA2023

    • Author(s)
      Akatsu Munetaka、Ehara Haruhiko、Kujirai Tomoya、Fujita Risa、Ito Tomoko、Osumi Ken、Ogasawara Mitsuo、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 299 Issue: 12 Pages: 105477-105477

    • DOI

      10.1016/j.jbc.2023.105477

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
  • [Journal Article] Structural Transition of the Nucleosome during Transcription Elongation2023

    • Author(s)
      Kujirai Tomoya、Ehara Haruhiko、Sekine Shun-ichi、Kurumizaka Hitoshi
    • Journal Title

      Cells

      Volume: 12 Issue: 10 Pages: 1388-1388

    • DOI

      10.3390/cells12101388

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475
  • [Journal Article] Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II2023

    • Author(s)
      Oishi Takumi、Hatazawa Suguru、Kujirai Tomoya、Kato Junko、Kobayashi Yuki、Ogasawara Mitsuo、Akatsu Munetaka、Ehara Haruhiko、Sekine Shun-ichi、Hayashi Gosuke、Takizawa Yoshimasa、Kurumizaka Hitoshi
    • Journal Title

      Nucleic Acids Research

      Volume: 51 Issue: 19 Pages: 10364-10374

    • DOI

      10.1093/nar/gkad754

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
  • [Journal Article] Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.82023

    • Author(s)
      Hirai Seiya、Kujirai Tomoya、Akatsu Munetaka、Ogasawara Mitsuo、Ehara Haruhiko、Sekine Shun-ichi、Ohkawa Yasuyuki、Takizawa Yoshimasa、Kurumizaka Hitoshi
    • Journal Title

      The Journal of Biochemistry

      Volume: 174 Issue: 6 Pages: 549-559

    • DOI

      10.1093/jb/mvad069

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-22K19275, KAKENHI-PROJECT-22KJ0858, KAKENHI-PUBLICLY-22H04676, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23H00372, KAKENHI-PROJECT-23K20300
  • [Journal Article] Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome2023

    • Author(s)
      Osumi Ken、Kujirai Tomoya、Ehara Haruhiko、Ogasawara Mitsuo、Kinoshita Chiaki、Saotome Mika、Kagawa Wataru、Sekine Shun-ichi、Takizawa Yoshimasa、Kurumizaka Hitoshi
    • Journal Title

      Journal of Molecular Biology

      Volume: 435 Issue: 13 Pages: 168130-168130

    • DOI

      10.1016/j.jmb.2023.168130

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300, KAKENHI-PROJECT-23K24997
  • [Journal Article] Structures of dengue virus RNA replicase complexes2023

    • Author(s)
      Osawa Takuo、Aoki Mari、Ehara Haruhiko、Sekine Shun-ichi
    • Journal Title

      Molecular Cell

      Volume: 83 Issue: 15 Pages: 2781-2791.e4

    • DOI

      10.1016/j.molcel.2023.06.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K05662, KAKENHI-PROJECT-20H05690
  • [Journal Article] ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes2023

    • Author(s)
      Bunch Heeyoun、Kim Deukyeong、Naganuma Masahiro、Nakagawa Reiko、Cong Anh、Jeong Jaehyeon、Ehara Haruhiko、Vu Hongha、Chang Jeong Ho、Schellenberg Matthew J.、Sekine Shun-ichi
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41467-023-44089-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Journal Article] Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT2022

    • Author(s)
      Ehara Haruhiko、Kujirai Tomoya、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
    • Journal Title

      Science

      Volume: 377 Issue: 6611

    • DOI

      10.1126/science.abp9466

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
  • [Journal Article] Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H12022

    • Author(s)
      Hirano Rina、Ehara Haruhiko、Kujirai Tomoya、Uejima Tamami、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 7287-7287

    • DOI

      10.1038/s41467-022-35003-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
  • [Journal Article] Overview of the “1SBA: Integrative approaches towards understanding of gene expression” session at the 57th BSJ meeting2020

    • Author(s)
      Takaharu Mori and Shun-ichi Sekine
    • Journal Title

      Biophysical Reviews

      Volume: - Issue: 2 Pages: 253-254

    • DOI

      10.1007/s12551-020-00644-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K06532, KAKENHI-PROJECT-15H04344
  • [Journal Article] Structural insight into nucleosome transcription by RNA polymerase II with elongation factors2019

    • Author(s)
      Ehara Haruhiko、Kujirai Tomoya、Fujino Yuka、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
    • Journal Title

      Science

      Volume: 363 Issue: 6428 Pages: 744-747

    • DOI

      10.1126/science.aav8912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
  • [Journal Article] Architecture of the RNA polymerase II elongation complex: new insights into Spt4/5 and Elf12018

    • Author(s)
      Ehara Haruhiko、Sekine Shun-ichi
    • Journal Title

      Transcription

      Volume: 9 Issue: 5 Pages: 286-291

    • DOI

      10.1080/21541264.2018.1454817

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Journal Article] Structural basis of the nucleosome transition during RNA polymerase II passage2018

    • Author(s)
      Kujirai Tomoya、Ehara Haruhiko、Fujino Yuka、Shirouzu Mikako、Sekine Shun-ichi、Kurumizaka Hitoshi
    • Journal Title

      Science

      Volume: 362 Issue: 6414 Pages: 595-598

    • DOI

      10.1126/science.aau9904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
  • [Journal Article] Crystal structure of RNA polymerase II from Komagataella pastoris2017

    • Author(s)
      Ehara Haruhiko、Umehara Takashi、Sekine Shun-ichi、Yokoyama Shigeyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 487 Issue: 2 Pages: 230-235

    • DOI

      10.1016/j.bbrc.2017.04.039

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-16H05089
  • [Journal Article] A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation2017

    • Author(s)
      Ooi Wei-Yang、Murayama Yuko、Mekler Vladimir、Minakhin Leonid、Severinov Konstantin、Yokoyama Shigeyuki、Sekine Shun-ichi
    • Journal Title

      Nucleic Acids Research

      Volume: 46 Issue: 1 Pages: 431-441

    • DOI

      10.1093/nar/gkx1162

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15082, KAKENHI-PROJECT-15H04344
  • [Journal Article] Structure of the complete elongation complex of RNA polymerase II with basal factors2017

    • Author(s)
      Ehara Haruhiko、Yokoyama Takeshi、Shigematsu Hideki、Yokoyama Shigeyuki、Shirouzu Mikako、Sekine Shun-ichi
    • Journal Title

      Science

      Volume: 357 Issue: 6354 Pages: 921-924

    • DOI

      10.1126/science.aan8552

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05897, KAKENHI-PROJECT-15H04344
  • [Journal Article] The ratcheted and ratchetable structural States of RNA polymerase underlie multiple transcriptional functions.2015

    • Author(s)
      Sekine, S., Murayama, Y., Svetlov, V., Nudler, E., Yokoyama, S.
    • Journal Title

      Mol. Cell

      Volume: 57 Issue: 3 Pages: 408-421

    • DOI

      10.1016/j.molcel.2014.12.014

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Journal Article] Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations.2015

    • Author(s)
      Sekine, S., Murayama, Y., Svetlov, V., Nudler, E. and Yokoyama, S.
    • Journal Title

      Transcription

      Volume: 6 Issue: 3 Pages: 56-60

    • DOI

      10.1080/21541264.2015.1059922

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Journal Article] Time-resolved Raman and polyacrylamide gel electrophoresis observations of nucleotide incorporation and misincorporation in RNA within a bacterial RNA polymerase crystal.2015

    • Author(s)
      Antonopoulos, I.H., Murayama, Y., Warner, B.A., Sekine, S., Yokoyama, S., Carey, P.R.
    • Journal Title

      Biochemistry

      Volume: 54 Issue: 3 Pages: 652-665

    • DOI

      10.1021/bi501166r

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Journal Article] Molecular basis of RNA polymerase promoter specificity switch revealed through studies of Thermus bacteriophage transcription regulator.2014

    • Author(s)
      Severinov, K,. Minakhin, L., Sekine, S., Lopatina, A., Yokoyama, S.
    • Journal Title

      Bacteriophage

      Volume: 4

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Journal Article] Structural basis for promoter specificity switching of RNA polymerase by a phage factor2014

    • Author(s)
      Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K. and Yokoyama, S.
    • Journal Title

      Genes & Development

      Volume: 28 Issue: 5 Pages: 521-531

    • DOI

      10.1101/gad.233916.113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Journal Article] Development of a hexahistidine-3× FLAG-tandem affinity purification method for endogenous protein complexes in Pichia pastoris2014

    • Author(s)
      Toshiaki Higo, Noriyuki Suka, Haruhiko Ehara, Masatoshi Wakamori, Shin Sato, Hideaki Maeda, Shun-ichi Sekine, Takashi Umehara, and Shigeyuki Yokoyama
    • Journal Title

      J Struct Funct Genomics

      Volume: 15 Issue: 4 Pages: 191-199

    • DOI

      10.1007/s10969-014-9190-1

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23114005, KAKENHI-PROJECT-23370048, KAKENHI-PROJECT-24613007
  • [Journal Article] Structural basis of transcription by bacterial and eukaryotic RNA polymerases2012

    • Author(s)
      Sekine, S., Tagami, S. and Yokoyama, S.
    • Journal Title

      Curr. Opin. Struct. Biol.

      Volume: 22 Pages: 110-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structural basis of transcription by bacterial and eukaryotic RNA polymerases.2012

    • Author(s)
      Sekine, S., et al.
    • Journal Title

      Curr Opin Struct Biol.

      Volume: 22 Issue: 1 Pages: 110-118

    • DOI

      10.1016/j.sbi.2011.11.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23370048, KAKENHI-PROJECT-23770130
  • [Journal Article] 転写因子によるRNAポリメラーゼの制御のメカニズム-細菌の転写を阻害する新たな仕組みの解明2011

    • Author(s)
      関根俊一, et al.
    • Journal Title

      化学と生物

      Volume: 49 Pages: 732-734

    • Data Source
      KAKENHI-PROJECT-23370048
  • [Journal Article] Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA Polymerase III2011

    • Author(s)
      Ehara, H., Sekine, S. and Yokoyama, S.
    • Journal Title

      Protein Sci

      Volume: 20 Pages: 1558-1565

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] セレンをタンパク質に正確に取り込む:セレノシステインtRNA認識の構造基盤2011

    • Author(s)
      関根俊一, 横山茂之
    • Journal Title

      生物物理

      Volume: 51(6) Pages: 272-273

    • NAID

      10030038012

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] A novel conformation of RNA polymerase sheds light on the mechanism of transcription2011

    • Author(s)
      Tagami, S., Sekine, S. and Yokoyama, S.
    • Journal Title

      Transcription

      Volume: 2 Pages: 162-167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystallization and preliminary X-ray crystallographic analysis of Thermus thermophilus transcription elongation complex bound to Gfh1.2010

    • Author(s)
      Tagami S, Sekine S, Kumarevel T, Yamamoto M, Yokoyama S.
    • Journal Title

      Acta Crystallogr.Sect F. 66

      Pages: 64-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structural basis for the major role of O-phosphoseryl-tRNA kinase in the UGA-specific encoding of selenocysteine2010

    • Author(s)
      Chiba, S., Itoh, Y., Sekine, S. and Yokoyama, S.
    • Journal Title

      Mol. Cell

      Volume: 39 Pages: 410-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin2010

    • Author(s)
      Kuratani, M., Hirano, M., Goto-Ito, S., Itoh, Y., Hikida, Y., Nishimoto, M., Sekine, SI., Bessho, Y., Ito, T., Grosjean, H. and Yokoyama, S.
    • Journal Title

      J. Mol. Biol

      Volume: 401(3) Pages: 323-333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structural basis for the major role of O-phosphoseryl-tRNA kinase in the UGA-specific encoding of selenocysteine.2010

    • Author(s)
      Chiba, S., Itoh, Y., Sekine, S., Yokoyama, S.
    • Journal Title

      Mol.Cell 39

      Pages: 410-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein.2010

    • Author(s)
      Tagami, S., Sekine, S., Kumarevel, T., Hino, N., Murayama, Y., Kamegamori, S., Yamamoto, M., Sakamoto, K., Yokoyama, S.
    • Journal Title

      Nature 468

      Pages: 978-982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structural basis for the major role of O-phosphoseryl-tRNA kinase in the UGA-specific encoding of selenocysteine.2010

    • Author(s)
      Chiba, S., Itoh, Y., Sekine, S. and Yokoyama, S.
    • Journal Title

      Mol. Cell

      Volume: 39 Pages: 410-420

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein2010

    • Author(s)
      Tagami, S., Sekine, S., Kumarevel, T., Hino, N., Murayama, Y., Kamegamori, S., Yamamoto, M., Sakamoto, K. and Yokoyama, S.
    • Journal Title

      Nature

      Volume: 468 Pages: 978-982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structure of an archaeal homologue of the bacterial Fmu/RsmB/RrmB rRNA cytosine 5-methyltransferase2010

    • Author(s)
      Hikida, Y., Kuratani, M., Bessho, Y., Sekine, SI. and Yokoyama, S.
    • Journal Title

      Acta Crystallogr. D Biol. Crystallogr

      Volume: 66(12) Pages: 1301-1307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystallization and preliminary X-ray crystallographic analysis of Thermus thermophilus transcription elongation complex bound to Gfh12010

    • Author(s)
      Tagami, S., Sekine, SI., Kumarevel, T., Yamamoto, M. and Yokoyama, S.
    • Journal Title

      Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun

      Volume: 66(1) Pages: 64-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Structure of selenophosphate synthetase essential for selenium incorporation into proteins and RNAs.2009

    • Author(s)
      Itoh, Y., Sekine, S., Matsumoto, E., Akasaka, R., Takemoto, C., Shirouzu, M. and Yokoyama, S.
    • Journal Title

      J. Mol. Biol

      Volume: 385 Pages: 1456-1469

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization.2009

    • Author(s)
      Naganuma, M., Sekine, S., Fukunaga, R., Yokoyama, S.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 106

      Pages: 8489-8494

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Unique protein architecture of alanyl-tRNA synthetase for aminoacylation, editing, and dimerization2009

    • Author(s)
      Naganuma, M., Sekine, SI., Fukunaga, R. and Yokoyama, S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 106 Pages: 8489-8494

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystal structure of human selenocysteine tRNA.2009

    • Author(s)
      Itoh Y, Chiba S, Sekine S, Yokoyama S.
    • Journal Title

      Nucleic Acids Research 37

      Pages: 6259-6268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] Crystal structure of human selenocysteine tRNA.2009

    • Author(s)
      Itoh, Y., Chiba, S., Sekine, S. and Yokoyama S.
    • Journal Title

      Nucleic Acids Res

      Volume: 37 Pages: 6259-6268

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] Structure of selenophosphate synthetase essential for selenium incorporation into proteins and RNAs2009

    • Author(s)
      Itoh, Y., Sekine, SI., Matsumoto, E., Akasaka, R., Takemoto, C., Shirouzu, M. and Yokoyama, S.
    • Journal Title

      J. Mol. Biol

      Volume: 385 Pages: 1456-1469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystal structure of human selenocysteine tRNA2009

    • Author(s)
      Itoh, Y., Chiba, S., Sekine, SI. and Yokoyama, S.
    • Journal Title

      Nucleic Acids Res

      Volume: 37 Pages: 6259-6268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Journal Article] Crystallographic and mutational studies of seryl-tRNA synthetase from the archaeon Pyrococcus horikoshii.2008

    • Author(s)
      Itoh, Y., Sekine, S., Kuroishi, C., Terada, T., Shirouzu, M., Kuramitsu, S. and Yokoyama, S.
    • Journal Title

      RNA Biol

      Volume: 5 Pages: 169-177

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Journal Article] Structure of an N-terminally truncated selenophosphate synthetase from Aquifex aeolicus.2008

    • Author(s)
      Matsumoto, E., Sekine, S., Akasaka, R., Otta, Y., Katsura, K., Inoue, M., Kaminishi, T., Terada, T., Shirouzu, M. and Yokoyama, S.
    • Journal Title

      Acta Crystallogr

      Volume: F64 Pages: 453-458

    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] RNAポリメラーゼによる転写伸長と終結のメカニズム2023

    • Author(s)
      関根俊一
    • Organizer
      よこはまNMR研究会 第70回ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] 転写におけるヌクレオソームの崩壊と再構築の構造解析2023

    • Author(s)
      鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
    • Organizer
      第16回日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] Cryo-EM analysis on the nucleosome disassembly and reassembly during transcription elongation2023

    • Author(s)
      Ehara H, Kujirai Y, Shirouzu M, Kurumizaka H, Sekine S
    • Organizer
      CSHL MECHANISMS OF EUKARYOTIC TRANSCRIPTION
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] デングウイルスのゲノム複製複合体のクライオ電子顕微鏡解析2023

    • Author(s)
      関根俊一
    • Organizer
      第70回 日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] クロマチン転写の構造生物学2023

    • Author(s)
      江原晴彦、鯨井智也、白水美香子、胡桃坂仁志、関根俊一
    • Organizer
      第23回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] Structural basis of nucleosome transcription by the RNAPII elongation complex2023

    • Author(s)
      Sekine S, Ehara H, Kujirai Y, Kurumizaka H
    • Organizer
      CSHL MECHANISMS OF EUKARYOTIC TRANSCRIPTION
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] 転写伸長におけるヌクレオソームの崩壊と再構築機構の構造生物学的解析2022

    • Author(s)
      鯨井 智也、江原 晴彦、白水 美香子、関根 俊一、胡桃坂 仁志
    • Organizer
      第40 回染色体ワークショップ・第21 回核ダイナミクス研究会
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] Structural basis of nucleosome transcription by the RNAPII elongation complex2022

    • Author(s)
      Sekine Shun-ichi
    • Organizer
      SBDR Webinar
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] 転写におけるヌクレオソーム構造のダイナミクス2022

    • Author(s)
      鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
    • Organizer
      第15回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] 転写におけるヌクレオソーム構造変換のクライオEM構造解析2022

    • Author(s)
      鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
    • Organizer
      生理研研究会「新世代のクライオ電子顕微鏡」
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] Structural basis of RNA polymerase II transcription on nucleosomal DNA2021

    • Author(s)
      Shun-ichi Sekine
    • Organizer
      RIKEN BDR symposium 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] クライオ電子顕微鏡による核内での転写の構造基盤2021

    • Author(s)
      関根俊一
    • Organizer
      よこはまNMR研究会 第66回ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] 理研横浜クライオ電子顕微鏡施設2021

    • Author(s)
      関根俊一
    • Organizer
      日本分子生物学会 第44回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] Structural Basis of Nucleosome Transcription by RNA Polymerase II2020

    • Author(s)
      Shun-ichi Sekine
    • Organizer
      3rd HKUST IAS Focused Program on Mechanisms of Gene Transcription and Its Regulations
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05690
  • [Presentation] RNA ポリメラーゼ II によるクロマチン転写の構造基盤2019

    • Author(s)
      関根俊一
    • Organizer
      日本植物学会第83回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Structural basis of cellular transcription by RNA polymerase II2019

    • Author(s)
      関根俊一
    • Organizer
      第19回日本蛋白質科学会年会 第71回日本細胞生物学会年会 合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Structural basis of chromatin transcription by RNA polymerase II2019

    • Author(s)
      関根俊一
    • Organizer
      Gordon Research Conference Mechanisms of Microbial Transcription
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Structural basis of the RNA polymerase II elongation complex with basal factors2019

    • Author(s)
      関根俊一
    • Organizer
      CSHL Meeting Mechanisms of Eukaryotic Transcription
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Structural basis of nucleosome transcription by RNA polymerase II2019

    • Author(s)
      関根俊一
    • Organizer
      日本生物物理学会 第57回年会
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Architecture of the RNA polymerase II elongation complex with basal elongation factors2018

    • Author(s)
      Shun-ichi Sekine
    • Organizer
      IAS Focused Program on Mechanisms of Gene Transcription and its Regulations
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] RNAポリメラーゼIIによるクロマチン転写のメカニズム2018

    • Author(s)
      関根 俊一
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] RNAポリメラーゼIIによるクロマチン転写のメカニズム2018

    • Author(s)
      関根 俊一
    • Organizer
      蛋白質研究所セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Structural basis of host RNA polymerase inhibition by a Thermus phage protein gp762017

    • Author(s)
      Shun-ichi Sekine
    • Organizer
      FASEB SRC “Mechanisms and Regulation of Prokaryotic Transcription"
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] バクテリオファージによる宿主RNAポリメラーゼ調節の構造基盤2016

    • Author(s)
      関根 俊一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] Ratcheting of RNA polymerase for the multiple transcription functions2015

    • Author(s)
      関根 俊一
    • Organizer
      FASEB SRC Mechanism and Regulation of Prokaryotic Transcription
    • Place of Presentation
      Saxtons River, USA
    • Year and Date
      2015-06-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04344
  • [Presentation] SMART: an S-S based method to detect RNA polymerase conformational change2013

    • Author(s)
      関根俊一
    • Organizer
      The 65th Fujihara Seminar International Symposium on Synthetic Biology of Unnatural Base Pairs and Amino Acids
    • Place of Presentation
      苫小牧 グランドホテルニュー王子
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] Structural basis for promoter switching of RNA polymerase by a phage-encoded protein2013

    • Author(s)
      関根俊一
    • Organizer
      The 7th International Conference on Structural Genomics 2013 - Structural Life Science (ICSG2013-SLS)
    • Place of Presentation
      札幌 京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] R/T conformational switching of RNA polymerase for the multiple transcription functions.2013

    • Author(s)
      関根俊一
    • Organizer
      FASEB Science Research Conference, Mechanism & Regulation of Prokaryotic Transcription
    • Place of Presentation
      Saxtons River, USA
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] Structural basis for promoter switching of RNA polymerase by a phage-encoded factor2013

    • Author(s)
      関根俊一
    • Organizer
      FASEB Science Research Conference, Mechanism & Regulation of Prokaryotic Transcription
    • Place of Presentation
      Saxtons River, USA
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] 転写の校正反応においてRNAポリメラーゼの構造と活性を切りかえるメカニズム2012

    • Author(s)
      関根 俊一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] 転写校正においてRNAポリメラーゼの構造と活性を切りかえるメカニズム2012

    • Author(s)
      関根 俊一
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23370048
  • [Presentation] Crystallographic Studies of Aminoacyl-tRNA Synthesis and tRNA Modification2010

    • Author(s)
      Itoh, Y., Chiba, S., Naganuma, M., Goto-ito, S., Fukunaga, R., Kuratani, M., Bessho, Y., Ito, T., Sekine, SI., Yokoyama, S.
    • Organizer
      23rd tRNA Workshop
    • Place of Presentation
      Aveiro, Portugal
    • Year and Date
      2010-01-29
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Presentation] ヒトのセレノシステインtRNAの結晶構造解析2009

    • Author(s)
      伊藤弓弦、千葉志穂、関根俊一、横山茂之
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] セレノシステイン合成酵素の結晶構造解析2009

    • Author(s)
      伊藤弓弦、関根俊一、横山茂之
    • Organizer
      第11回RNAミーティング
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] Structural basis of transcription regulation revealed by the crystal structure of Thermus thermophilus RNA polymerase elongation complex bound with a transcriptional regulator Gfh12009

    • Author(s)
      関根俊一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Presentation] Structural basis of transcription regulation revealed by the crystal structure of Thermus thermophilus RNA polymerase elongation complex bound with a transcriptional regulator Gfh1.2009

    • Author(s)
      関根俊一、田上俊輔、Thirumananseri Kumarevel、横山茂之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Presentation] セレノシステイン合成酵素の結晶構造解析2009

    • Author(s)
      伊藤弓弦、関根俊一、横山茂之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] Crystal structure of an RNA polymerase translocation intermediate.2009

    • Author(s)
      田上俊輔、関根俊一、Thirumananseri Kumarevel、横山茂之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20247008
  • [Presentation] Implications for selenophosphate generation by crystal structure of selenophosphate synthetase2008

    • Author(s)
      Sekine, S., et al.
    • Organizer
      IUCR 2008
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] セレノリン酸合成酵素SPSの結晶構造2008

    • Author(s)
      関根俊一
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] Implications for selenophosphate generation by crystal structure of selenophosphate synthetase2008

    • Author(s)
      関根俊一
    • Organizer
      XXI Congress of the international Union of Crystallography (IUCr2008)
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2008-08-23
    • Data Source
      KAKENHI-PROJECT-20570148
  • [Presentation] 新生RNAによるRNAポリメラーゼの構造変化と機能との相関

    • Author(s)
      関根俊一
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-23370048
  • 1.  鯨井 智也 (70823566)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  ITO Takuhiro (70401164)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 3.  FUJII Yoshifumi (30392096)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  YOKOYAMA Shigeyuki (00159229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 18 results
  • 5.  松下 智直 (20464399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  多田 安臣 (40552740)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  花田 耕介 (50462718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  鈴木 孝征 (50535797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  関 真秀 (90749326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  江原 晴彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  森 貴治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  村山 祐子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  滝沢 由政
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  大澤 拓生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  重松 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  須賀 則之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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