Kihara Akio 木原章雄

… Alternative Names

KIHARA Akio 木原章雄

Less

Researcher Number	50333620
Other IDs	https://orcid.org/0000-0001-5889-0788
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 北海道大学, 薬学研究院, 教授 2011 – 2015: 北海道大学, 薬学研究科(研究院), 教授 2008 – 2012: Hokkaido University, 大学院・薬学研究院, 教授 2010: 北海道大学, 薬学研究院, 教授 2007: Hokkaido University, Faculty of Pharmaceutical Sciences, Associate Professor … More 2006: 北海道大学, 大学院薬学研究院, 助教授 2006: 大学院薬学研究院, 助教授 2004 – 2005: 北海道大学, 大学院・薬学研究科, 助教授 2003: 北海道大学, 薬学研究科, 助手 2001 – 2003: 北海道大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Biological Sciences / Cell biology / Broad Section H / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological pharmacy Except Principal Investigator Functional biochemistry / Functional biochemistry / Biological Sciences
Keywords	Principal Investigator 脂質 / スフィンゴ脂質 / 生体膜 / 代謝 / シグナル伝達 / スフィンゴシン1-リン酸 / 極長鎖脂肪酸 / 脂肪酸 / グリセロリン脂質 / アルデヒドデヒドロゲナーゼ … More / 脂質非対称 / 翻訳後修飾 / パルミトイル化 / セラミド / 皮膚 / ノックアウトマウス / 脂質メディエーター / タンパク質 / 遺伝子 / 脂質修飾 / 細胞膜 / 質量分析 / バリア形成 / アルファ酸化 / バリア / 小胞体 / 蛋白質 / 生体分子 / 細胞・組織 / フロッパーゼ / ユビキチン化 / アルカリ / リン脂質 / 脂質二重層 / Rim101経路 / Gタンパク質共役型受容体 / プロテインアシルトランスフェラーゼ / ゲラニルゲラニル化 / 脂肪族アルデヒドデヒドロゲナーゼ / 代謝異常症 / シェーグレン・ラルソン症候群 / 神経疾患 / 皮膚疾患 / センサー / リポソーム / エンドソーム / 皮膚バリア機能 / 小胞輪送 / 小胞輸送 / 代謝異常 / 皮膚バリア / アシルCoA合成酵素 / 生理活性脂質 / 3-ヒドロキシアシルCoA脱水酵素 / アシルCoA / 縮合酵素 / 脂質輸送 / ホスファチジルイノシトール / 細胞内輸送 / アシルトランスフェラーゼ / リゾホスファチジン酸 / 受容体 / 三量体Gタンパク質共役型受容体 / 長鎖塩基 / アルカリ応答 / Rim101 / 長鎖塩基1-リン酸 / 脂質二重膜 / 脂質分子 / トランスロカーゼ / トランスポート / 細胞内動態 / 蛋白質輸送 / 酵母 / スフィンゴシンキナーゼ … More Except Principal Investigator スフィンゴシン1-リン酸 / 生理活性脂質 / スフィンゴシンキナーゼ / Edg受容体 / セラミド / 糖脂質 / スフィンゴ脂質 / immunusupressant / mast cell / ceramide / C1P / Sphingosine 1-phosphate (S1P) / bioactive / biomolecule / sphingolipid / 血漿 / セミラド1-リン酸 / セミラド / 免疫抑制剤 / マスト細胞 / セラミド1-リン酸 / 生理活性 / 生体分子 / 脂質 / lipid signaling / alycolipids / sphingosine kinase / ABC transporter / lysophosphatidic acid / Edg Receptors / sphingosine1-phosphate / bioactive lipids / GPCR / リゾボスファチジン酸 / 脂質シグナリング / ABCトランスポーター / リゾホスファチジン酸 / G蛋白質 / 細胞内脂質輸送 / 細胞膜ミクロドメイン / アポトーシス / シグナル伝達 Less

Formation of biological barriers by diverse ceramidesPrincipal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Hokkaido University
Regulation of biological functions by very long-chain lipids and molecular mechanism of the related pathologyPrincipal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Hokkaido University
Metabolic pathways creating and maintaining ceramide diversity, and molecular mechanism of the pathology due to their impairmentPrincipal Investigator
- Principal Investigator
  
  Kihara Akio
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Hokkaido University
Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolismPrincipal Investigator
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
スフィンゴシン1-リン酸代謝経路に関わる遺伝子の同定と関連疾患の解析Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
パルミトイル化によるタンパク質機能調節と病態の分子機構Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Elucidation of the molecular mechanism sensing lipid asymmetry and transducing the signalsPrincipal Investigator
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
スフィンゴシン１－リン酸代謝経路の解明とシェーグレン・ラルソン症候群の原因究明Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acidsPrincipal Investigator
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Identification of the sensor molecule that senses lipid asymmetry and elucidation of the molecular mechanism of its intracellular signalingPrincipal Investigator
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Hokkaido University
三量体Gタンパク質共役型受容体の脂質修飾による新たな制御機構の解明Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 familyPrincipal Investigator
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Biological functions of Sphingolipids and their relevance to pathological phenomena
- Principal Investigator
  
  YASUYUKI Igarashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
細胞膜脂質非対称の制御機構及び脂質非対称シグナルの解明Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
細胞内スフィンゴシン1-リン酸の機能と動態の解明Principal Investigator
- Principal Investigator
  
  木原章雄
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Molecular Mechanism of production and secretion of platelet-derived bioactive lysolipids
- Principal Investigator
  
  IGARASHI Yasuyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析
- Principal Investigator
  
  IGARASHI Yasuyuki
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University

[Book] 進化する皮膚科学2021
- Author(s)
  椛島健治，一條遼，豊島文子，久保允人，森山麻里子，森山博由，鈴木浩也，徳増玲太郎，田中啓雄，田村淳，月田早智子，佐藤隆，木原章雄，髙山喜晴，山野美怜，亀井大嗣，伊藤良樹，冨田秀太，橋田裕美子，大畑雅典，その他
- Total Pages
  426
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860437336
- Data Source
  KAKENHI-PROJECT-18H03976
[Book] セラミド研究の新展開　～基礎から応用へ～2019
- Author(s)
  木原章雄
- Total Pages
  12
- Publisher
  食品化学新聞社
- ISBN
  9784916143358
- Data Source
  KAKENHI-PROJECT-18H03976
[Book] セラミド研究の新展開　～基礎から応用へ～2019
- Author(s)
  木原章雄
- Total Pages
  12
- Publisher
  セラミド研究会
- ISBN
  9784916143358
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Book] Bioactive lipid mediators: current reviews and protocols2015
- Author(s)
  Kihara A
- Total Pages
  426
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-26251010
[Book] 「極長鎖脂肪酸伸長とセラミド合成」ここまできたセラミド研究最前線セラミドー基礎と応用ー2011
- Author(s)
  大野祐介, 木原章雄
- Publisher
  食品化学新聞社
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases2024
- Author(s)
  Kato Ryoya, Takenaka Yuka, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 2 Pages: 105656-105656
- DOI
  10.1016/j.jbc.2024.105656
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04986
[Journal Article] Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains2024
- Author(s)
  Yamamoto Yuta, Sassa Takayuki, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 113 Issue: 1 Pages: 10-17
- DOI
  10.1016/j.jdermsci.2023.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Determining the structure of protein-bound ceramides, essential lipids for skin barrier function2023
- Author(s)
  Ohno Yusuke, Nakamura Tetsuya, Iwasaki Takafumi, Katsuyama Akira, Ichikawa Satoshi, Kihara Akio
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 11 Pages: 108248-108248
- DOI
  10.1016/j.isci.2023.108248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides2023
- Author(s)
  Ota Ai, Morita Hiroya, Naganuma Tatsuro, Miyamoto Masatoshi, Jojima Keisuke, Nojiri Koki, Matsuda Junko, Kihara Akio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 10 Issue: 4 Pages: 104603-104603
- DOI
  10.1016/j.jbc.2023.104603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K08792
[Journal Article] Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production via α-oxidation in vivo2023
- Author(s)
  Mori Keisuke、Naganuma Tatsuro、Kihara Akio
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 34 Issue: 9
- DOI
  10.1091/mbc.e23-02-0042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06583, KAKENHI-PROJECT-22H04986
[Journal Article] 多様なセラミドによる皮膚の透過性バリア形成2023
- Author(s)
  木原章雄
- Journal Title
  
  Farumashia
  
  Volume: 59 Issue: 1 Pages: 34-38
- DOI
  10.14894/faruawpsj.59.1_34
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22H04986
[Journal Article] Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS32023
- Author(s)
  Jojima Keisuke、Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1868 Issue: 8 Pages: 159335-159335
- DOI
  10.1016/j.bbalip.2023.159335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KJ0087, KAKENHI-PROJECT-22H04986
[Journal Article] Involvement of ω-O-acylceramides and protein-bound ceramides in oral permeability barrier formation2023
- Author(s)
  Sassa Takayuki, Kihara Akio
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 4 Pages: 112363-112363
- DOI
  10.1016/j.celrep.2023.112363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Incomplete elongation of ultra-long-chain polyunsaturated acyl-CoAs by the fatty acid elongase ELOVL4 in spinocerebellar ataxia type 342023
- Author(s)
  Tamura Yuka, Sassa Takayuki, Nishizawa Takumi, Kihara Akio
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 43 Issue: 2 Pages: 85-101
- DOI
  10.1080/10985549.2023.2169563
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] スフィンゴ脂質の多様性とセラミドの皮膚バリア機能2023
- Author(s)
  木原章雄
- Journal Title
  
  実験医学
  
  Volume: 41 Pages: 49-56
- Data Source
  KAKENHI-PROJECT-22H04986
[Journal Article] An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis2022
- Author(s)
  Bhaduri Satarupa, Aguayo Analine, Ohno Yusuke, Proietto Marco, Jung Jasmine, Wang Isabel, Kandel Rachel, Singh Narinderbir, Ibrahim Ikran, Fulzele Amit, Bennett Eric J, Kihara Akio, Neal Sonya E
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 4
- DOI
  10.15252/embj.2022112275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Hypomyelinating spastic dyskinesia and ichthyosis caused by a homozygous splice site mutation leading to exon skipping in ELOVL12022
- Author(s)
  Takahashi Taiko, Mercan Sevcan, Sassa Takayuki, Akcapinar Gunseli Bayram, Yararbas Kanay, Susgun Seda, Iseri Sibel Aylin Ugur, Kihara Akio, Akcakaya Nihan Hande
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 6 Pages: 391-400
- DOI
  10.1016/j.braindev.2022.03.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA12022
- Author(s)
  Nohara Tomohiro, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 107 Issue: 2 Pages: 89-94
- DOI
  10.1016/j.jdermsci.2022.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Formation of fatty alcohols -components of meibum lipids- by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention2022
- Author(s)
  Otsuka Kento, Sawai‐Ogawa Megumi, Kihara Akio
- Journal Title
  
  The FASEB Journal
  
  Volume: 36 Issue: 4
- DOI
  10.1096/fj.202101733r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19J22148
[Journal Article] Ceramide Analysis in Combination With Genetic Testing May Provide a Precise Diagnosis for Self-Healing Collodion Babies2022
- Author(s)
  Takeichi Takuya, Ohno Yusuke, Tanahashi Kana, Ito Yasutoshi, Shiraishi Ken, Utsunomiya Ryo, Yoshida Satoshi, Ikeda Kenta, Nomura Hayato, Morizane Shin, Sayama Koji, Ogi Tomoo, Muro Yoshinao, Kihara Akio, Akiyama Masashi
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 63 Issue: 12 Pages: 100308-100308
- DOI
  10.1016/j.jlr.2022.100308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-21H02941
[Journal Article] Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases2022
- Author(s)
  Suzuki Madoka, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 63 Issue: 7 Pages: 100235-100235
- DOI
  10.1016/j.jlr.2022.100235
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08372, KAKENHI-PROJECT-22H04986
[Journal Article] Ceramide profiling of stratum corneum in Sjogren-Larsson syndrome2022
- Author(s)
  Arai Ayami, Takeichi Takuya, Wakamoto Hiroyuki, Sassa Takayuki, Ito Yasutoshi, Murase Yuya, Ogi Tomoo, Akiyama Masashi, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 107 Issue: 3 Pages: 114-122
- DOI
  10.1016/j.jdermsci.2022.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-21H02941
[Journal Article] Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations2021
- Author(s)
  Yamamoto Moe、Sassa Takayuki、Kyono Yuki、Uemura Hiroyasu、Kugo Masaaki、Hayashi Hideki、Imai Yasutomo、Yamanishi Kiyofumi、Kihara Akio
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Issue: 4 Pages: 447-456
- DOI
  10.1111/1346-8138.15725
- NAID
  120007186306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals2021
- Author(s)
  Tanno Honoka, Sassa Takayuki, Sawai Megumi, Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1866 Issue: 1 Pages: 158842-158842
- DOI
  10.1016/j.bbalip.2020.158842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K07060
[Journal Article] Direct uptake of sphingosine-1-phosphate independent of phospholipid phosphatases2021
- Author(s)
  Goto Hirotaka, Miyamoto Masatoshi, Kihara Akio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100605-100605
- DOI
  10.1016/j.jbc.2021.100605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] Protein‐bound ceramide levels in the epidermis of transglutaminase 1‐deficient mice2021
- Author(s)
  Sassa Takayuki、Imai Yasutomo、Kihara Akio、Yamanishi Kiyofumi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Issue: 11 Pages: 1799-1801
- DOI
  10.1111/1346-8138.16113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome2021
- Author(s)
  Nojiri Koki、Fudetani Shuhei、Arai Ayami、Kitamura Takuya、Sassa Takayuki、Kihara Akio
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 41 Issue: 10
- DOI
  10.1128/mcb.00352-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations2021
- Author(s)
  Nohara Tomohiro, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 101 Issue: 1 Pages: 69-71
- DOI
  10.1016/j.jdermsci.2020.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS2020
- Author(s)
  Kawana Momoko、Miyamoto Masatoshi、Ohno Yusuke、Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61 Issue: 6 Pages: 884-895
- DOI
  10.1194/jlr.ra120000671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06556, KAKENHI-PROJECT-18H03976
[Journal Article] Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast2020
- Author(s)
  Mori Keisuke, Obara Takashi, Seki Naoya, Miyamoto Masatoshi, Naganuma Tatsuro, Kitamura Takuya, Kihara Akio
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 61 Issue: 7 Pages: 1104-1114
- DOI
  10.1194/jlr.ra120000803
- NAID
  120007126048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K17816
[Journal Article] Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease2020
- Author(s)
  Miyamoto Masatoshi、Sassa Takayuki、Sawai Megumi、Kihara Akio
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.53582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production2020
- Author(s)
  Miyamoto Masatoshi、Itoh Narumi、Sawai Megumi、Sassa Takayuki、Kihara Akio
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 140 Issue: 2 Pages: 319-326
- DOI
  10.1016/j.jid.2019.07.689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976
[Journal Article] Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide2020
- Author(s)
  Yamamoto Haruka，Hattori Miku，Chamulitrat Walee，Ohno Yusuke，Kihara Akio
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 117 Issue: 6 Pages: 2914-2922
- DOI
  10.1073/pnas.1917525117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K06556
[Journal Article] Biosynthesis of the anti‐lipid‐microdomain sphingoid base 4,14‐sphingadiene by the ceramide desaturase FADS32020
- Author(s)
  Jojima Keisuke，Edagawa Mai，Sawai Megumi，Ohno Yusuke，Kihara Akio
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 2 Pages: 3318-3335
- DOI
  10.1096/fj.201902645r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976
[Journal Article] The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function2019
- Author(s)
  Hirabayashi Tetsuya、Murakami Makoto、Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1864 Issue: 6 Pages: 869-879
- DOI
  10.1016/j.bbalip.2018.09.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06978, KAKENHI-PLANNED-15H05905, KAKENHI-PUBLICLY-18H04664, KAKENHI-PUBLICLY-18H05025, KAKENHI-PROJECT-16H02613, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K22483, KAKENHI-ORGANIZER-15H05897
[Journal Article] スフィンゴ脂質クオリティによる生体防御2019
- Author(s)
  木原章雄
- Journal Title
  
  The Lipid
  
  Volume: 30 Pages: 28-34
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Journal Article] 極長鎖脂質による表皮および涙液における透過性バリア形成2019
- Author(s)
  木原章雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 269 Pages: 983-988
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy2019
- Author(s)
  Mueller Noomi, Sassa Takayuki, Morales-Gonzalez Susanne, Schneider Joanna, Salchow Daniel J, Seelow Dominik, Knierim Ellen, Stenzel Werner, Kihara Akio, Schuelke Markus
- Journal Title
  
  Journal of Medical Genetics
  
  Volume: 56 Issue: 3 Pages: 164-175
- DOI
  10.1136/jmedgenet-2018-105711
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-16K08220
[Journal Article] 小胞体における新たな脂肪酸α酸化経路2019
- Author(s)
  木原章雄
- Journal Title
  
  酵素工学ニュース
  
  Volume: 82 Pages: 22-25
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Journal Article] Yeast Mpo1 is a novel dioxygenase that catalyzes the α-oxidation of a 2-hydroxy fatty acid in an Fe2+-dependent manner2019
- Author(s)
  Seki Naoya, Mori Keisuke, Kitamura Takuya, Miyamoto Masatoshi, Kihara Akio
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 39 Issue: 5
- DOI
  10.1128/mcb.00428-18
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976
[Journal Article] 小胞体における新たな脂肪酸α酸化経路2019
- Author(s)
  木原章雄
- Journal Title
  
  酵素工学ニュース
  
  Volume: 82 Pages: 22-25
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] Neural symptoms in a gene knockout mouse model of Sjogren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide2019
- Author(s)
  Kanetake Tsukasa, Sassa Takayuki, Nojiri Koki, Sawai Megumi, Hattori Satoko, Miyakawa Tsuyoshi, Kitamura Takuya, Kihara Akio
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 1 Pages: 928-941
- DOI
  10.1096/fj.201800291r
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976
[Journal Article] スフィンゴ脂質クオリティによる生体防御2019
- Author(s)
  木原章雄
- Journal Title
  
  The Lipid
  
  Volume: 30 Pages: 28-34
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl12019
- Author(s)
  Isokawa Masashi、Sassa Takayuki、Hattori Satoko、Miyakawa Tsuyoshi、Kihara Akio
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Issue: 12 Pages: 747-759
- DOI
  10.1096/fba.2019-00067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07400, KAKENHI-PROJECT-19K07060, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-16H06276
[Journal Article] 脂質による皮膚バリア形成と疾患制御2018
- Author(s)
  村上誠, 木原章雄
- Journal Title
  
  実験医学
  
  Volume: 36 Pages: 160-167
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Journal Article] 鎖長の違いによる脂肪酸クオリティ - 極長鎖・超長鎖脂肪酸の産生機構と病態2018
- Author(s)
  木原章雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 264 Pages: 966-971
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Molecular mechanism of the ichthyosis pathology of Chanarin-Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5.2018
- Author(s)
  Ohno Y., Nara A., Nakamichi S., and Kihara A.
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: 92 Issue: 3 Pages: 245-253
- DOI
  10.1016/j.jdermsci.2018.11.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10113, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-15H05589
[Journal Article] Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice.2018
- Author(s)
  Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 4 Pages: 741-749
- DOI
  10.1016/j.jid.2017.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-17K15452
[Journal Article] スフィンゴ脂質長鎖塩基の代謝と脂肪酸α酸化2018
- Author(s)
  木原章雄
- Journal Title
  
  Plant Morphology
  
  Volume: 30 Pages: 5-14
- NAID
  130007622407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] スフィンゴ脂質代謝と疾患制御2018
- Author(s)
  木原章雄
- Journal Title
  
  実験医学
  
  Volume: 36 Pages: 46-52
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Journal Article] Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals2018
- Author(s)
  Edagawa Mai, Sawai Megumi, Ohno Yusuke, Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1863 Issue: 12 Pages: 1441-1448
- DOI
  10.1016/j.bbalip.2018.09.002
- NAID
  120006776810
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-15H05589
[Journal Article] スフィンゴ脂質長鎖塩基の代謝と脂肪酸α酸化2018
- Author(s)
  木原章雄
- Journal Title
  
  Plant Morphology
  
  Volume: 30 Pages: 5-14
- NAID
  130007622407
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Journal Article] Sphingolipids activate the endoplasmic reticulum stress surveillance pathway2018
- Author(s)
  Pina F, Yagisawa F, Obara K, Gregerson JD, Kihara A, Niwa M
- Journal Title
  
  J. Cell Biol.
  
  Volume: 217 Issue: 2 Pages: 495-505
- DOI
  10.1083/jcb.201708068
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice2018
- Author(s)
  Sassa T, Tadaki M, Kiyonari H, Kihara A
- Journal Title
  
  FASEB J.
  
  Volume: 印刷中 Issue: 6 Pages: 2966-2978
- DOI
  10.1096/fj.201700947r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16K08220
[Journal Article] Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor2018
- Author(s)
  M.M.M. Swamy, Y Murai, Y Ohno, K Jojima, A Kihara, S Mitsutake, Y Igarashi, J Yu, M Yao, Y Suga, M Anetai and K Monde
- Journal Title
  
  Chem. Commun.
  
  Volume: 54 Issue: 90 Pages: 12758-12761
- DOI
  10.1039/c8cc05595e
- NAID
  120006767539
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07794, KAKENHI-PROJECT-17K19188, KAKENHI-PROJECT-18K14350, KAKENHI-PUBLICLY-17H05424, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-15H05589
[Journal Article] スフィンゴ脂質代謝と疾患制御2018
- Author(s)
  木原章雄
- Journal Title
  
  実験医学
  
  Volume: 36 Pages: 46-52
- Data Source
  KAKENHI-PROJECT-18H03976
[Journal Article] PNPLA1 is a transacylase essential for the generation of the skin barrier lipid omega-O-acylceramide2017
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Journal Title
  
  Nat. Commun.
  
  Volume: 8 Issue: 1 Pages: 14610-14610
- DOI
  10.1038/ncomms14610
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589
[Journal Article] Systematic analysis of Ca2+ homoeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles2017
- Author(s)
  Farzan Ghanegolmohammadi, Mitsunori Yoshida, Shinsuke Ohnuki, Yuko Sukegawa, Hiroki Okada, Keisuke Obara, Akio Kihara, Kuninori Suzuki, Tetsuya Kojima, Nozomu Yachie, Dai Hirata, Yoshikazu Ohya
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 28 Issue: 23 Pages: 3415-3427
- DOI
  10.1091/mbc.e17-04-0216
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01195, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H04402, KAKENHI-PROJECT-15H04483, KAKENHI-PROJECT-16K14691
[Journal Article] Phytosphingosine degradation pathway includes fatty acid alpha-oxidation reactions in the endoplasmic reticulum2017
- Author(s)
  Kitamura T, Seki N, Kihara A
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 114 Issue: 13 Pages: 2616-2623
- DOI
  10.1073/pnas.1700138114
- NAID
  120006347207
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-14J02202
[Journal Article] The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.2017
- Author(s)
  Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 37 Pages: 11538-11551
- DOI
  10.1074/jbc.m117.803171
- NAID
  120006517686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010
[Journal Article] Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia.2017
- Author(s)
  Takeichi T, Torrelo A, Lee JYW, Ohno Y, Lozano ML, Kihara A, Liu L, Yasuda Y, Ishikawa J, Murase T, Rodrigo AB, Fernández-Crehuet P, Toi Y, Mellerio J, Rivera J, Vicente V, Kelsell DP, Nishimura Y, Okuno Y, Kojima D, Ogawa Y, Sugiura K, Simpson MA, McLean WHI, Akiyama M, McGrath JA.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 137 Issue: 11 Pages: 2344-2353
- DOI
  10.1016/j.jid.2017.06.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19717, KAKENHI-PROJECT-15H04887, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-16K15546, KAKENHI-PROJECT-17K16247
[Journal Article] Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides2016
- Author(s)
  Kihara A
- Journal Title
  
  Prog. Lipid Res.
  
  Volume: 63 Pages: 50-69
- DOI
  10.1016/j.plipres.2016.04.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region2016
- Author(s)
  Sassa T, Hirayama T, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 14 Pages: 7477-7487
- DOI
  10.1074/jbc.m115.695858
- NAID
  120006024351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16K08220
[Journal Article] Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases2016
- Author(s)
  Narita T, Naganuma T, Sase Y, Kihara A
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 25469-25469
- DOI
  10.1038/srep25469
- NAID
  120005819300
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Disruption of the Sjogren-Larsson syndrome gene Aldh3a2 in mice increases keratinocyte growth and retards skin barrier recovery2016
- Author(s)
  Tatsuro Naganuma, Shuyu Takagi, Tsukasa Kanetake, Takuya Kitamura, Satoko Hattori, Tsuyoshi Miyakawa, Takayuki Sassa, Akio Kihara
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 印刷中 Issue: 22 Pages: 11676-11688
- DOI
  10.1074/jbc.m116.714030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J00744, KAKENHI-PROJECT-14J02202, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16H06276
[Journal Article] Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains2015
- Author(s)
  Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino K, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1851 Issue: 12 Pages: 1554-1565
- DOI
  10.1016/j.bbalip.2015.09.004
- NAID
  120005890015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] セラミドによる皮膚バリア形成2015
- Author(s)
  木原章雄
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 117-122
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.2015
- Author(s)
  Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 25 Pages: 7707-12
- DOI
  10.1073/pnas.1503491112
- NAID
  120005690012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15414, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-26670526
[Journal Article] HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth2015
- Author(s)
  Blondelle J, Ohno Y, Gache V, Guyot S, Storck S, Blanchard-Gutton N, Barthelemy I, Walmsley G, Rahier A, Gadin S, Maurer M, Guillaud L, Prola A, Ferry A, Aubin-Houzelstein G, Demarquoy J, Relaix F, Piercy RJ, Blot S, Kihara A, Tiret L, Pilot-Storck F
- Journal Title
  
  J. Mol. Cell Biol.
  
  Volume: 7 Issue: 5 Pages: 429-440
- DOI
  10.1093/jmcb/mjv049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589
[Journal Article] Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry.2015
- Author(s)
  Yamauchi S, Obara K, Uchibori K, Kamimura A, Azumi K, and Kihara A
- Journal Title
  
  J Cell Sci
  
  Volume: 128 Pages: 61-69
- DOI
  10.1242/jcs.153890
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440038, KAKENHI-PROJECT-25650059
[Journal Article] スフィンゴ脂質の多様性と多機能性2015
- Author(s)
  木原章雄
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 50-56
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.2015
- Author(s)
  Kitamura T, Takagi S, Naganuma T, Kihara A
- Journal Title
  
  Biochem J
  
  Volume: 465 Issue: 1 Pages: 79-87
- DOI
  10.1042/bj20140624
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J00744, KAKENHI-PROJECT-14J02202, KAKENHI-PUBLICLY-25116701, KAKENHI-PUBLICLY-25117701
[Journal Article] Phs1 and the synthesis of very long chain fatty acids are required for ballistospore formation2014
- Author(s)
  Ianiri G, Abhyankar R, Kihara A, Idnurm A
- Journal Title
  
  PLos One
  
  Volume: 9 Issue: 8 Pages: e105147-e105147
- DOI
  10.1371/journal.pone.0105147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26251010
[Journal Article] Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle.2014
- Author(s)
  Naganuma T, Kihara A
- Journal Title
  
  PLos One
  
  Volume: 9 Issue: 7 Pages: e101823-e101823
- DOI
  10.1371/journal.pone.0101823
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J00744, KAKENHI-PROJECT-26251010
[Journal Article] Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine-1-phosphate metabolic pathway and in fatty acid elongation2014
- Author(s)
  Wakashima T, Abe K, Kihara A
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289 Issue: 36 Pages: 24736-24748
- DOI
  10.1074/jbc.m114.571869
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25116701, KAKENHI-PROJECT-26251010
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  Journal of lipid research
  
  Volume: 55 Issue: 3 Pages: 524-530
- DOI
  10.1194/jlr.m044586
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073
[Journal Article] Signaling events of the Rim101 pathway occur at the plasma membrane in a ubiquitination-dependent manner.2014
- Author(s)
  Obara K and Kihara A
- Journal Title
  
  Mol Cell Biol
  
  Volume: 34 Issue: 18 Pages: 3525-3534
- DOI
  10.1128/mcb.00408-14
- NAID
  120005525215
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440038, KAKENHI-PROJECT-25650059
[Journal Article] Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids2014
- Author(s)
  Kihara A
- Journal Title
  
  Biochimica et biophysica acta
  
  Volume: 1841 Issue: 5 Pages: 766-772
- DOI
  10.1016/j.bbalip.2013.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116701
[Journal Article] スフィンゴ脂質の代謝と関連疾患2014
- Author(s)
  木原章雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 248 Pages: 1112-1118
- Data Source
  KAKENHI-PUBLICLY-25116701
[Journal Article] Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress2014
- Author(s)
  Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 111 Issue: 8 Pages: 3080-3085
- DOI
  10.1073/pnas.1311022111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790322, KAKENHI-PUBLICLY-25116701, KAKENHI-PROJECT-26460577
[Journal Article] Metabolism of very long-chain fatty acids : genes and pathophysiology2014
- Author(s)
  Sassa T, Kihara A
- Journal Title
  
  Biomol. Ther
  
  Volume: 22 Issue: 2 Pages: 83-92
- DOI
  10.4062/biomolther.2014.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073
[Journal Article] スフィンゴ脂質の代謝と関連疾患2014
- Author(s)
  木原章雄
- Journal Title
  
  医学のあゆみ
  
  Volume: 248 Pages: 1112-1118
- Data Source
  KAKENHI-PUBLICLY-25117701
[Journal Article] Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids.2014
- Author(s)
  Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, Naganuma T, Kihara A
- Journal Title
  
  Nat Commun
  
  Volume: 5 Issue: 1 Pages: 5338-5338
- DOI
  10.1038/ncomms6338
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J00744, KAKENHI-PUBLICLY-25116701
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  J. Lipid Res.
  
  Volume: 55 Pages: 524-530
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] スフィンゴシン1-リン酸の代謝経路の全容と中間代謝体としての重要性2013
- Author(s)
  木原章雄
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 553-557
- NAID
  10031190084
- Data Source
  KAKENHI-PUBLICLY-25116701
[Journal Article] Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B12013
- Author(s)
  Kitamura T, Naganuma T, Abe K, Nakahara K, Ohno Y, Kihara A
- Journal Title
  
  Biochimica et biophysica acta
  
  Volume: 1831 Issue: 8 Pages: 1395-1401
- DOI
  10.1016/j.bbalip.2013.05.007
- NAID
  120005316992
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116701, KAKENHI-PUBLICLY-25117701
[Journal Article] スフィンゴシン1-リン酸の代謝経路2013
- Author(s)
  木原章雄
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 24 Pages: 175-179
- Data Source
  KAKENHI-PUBLICLY-25116701
[Journal Article] Effects on vesicular transport pathways at the late endosome in cells with limited very long-chain fatty acids2013
- Author(s)
  Obara K, Kojima R, Kihara A
- Journal Title
  
  J. Lipid Res.
  
  Volume: 54 Issue: 3 Pages: 831-842
- DOI
  10.1194/jlr.m034678
- NAID
  120005228358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Congenital myopathy is caused by mutation of HACD12013
- Author(s)
  Muhammad E, Reish O, Ohno Y, Scheetz T, Deluca A, Searby C, Regev M, Benyamini L, Fellig Y, Kihara A, Sheffield VC, Parvari R
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 22 Issue: 25 Pages: 5229-5236
- DOI
  10.1093/hmg/ddt380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-25870001
[Journal Article] Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile2013
- Author(s)
  Abe K, Ohno Y, Sassa T, Taguchi R, Çali şkan, M, Ober C, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 51 Pages: 36741-36749
- DOI
  10.1074/jbc.m113.493221
- NAID
  120005385316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PUBLICLY-25116701, KAKENHI-PROJECT-25870001
[Journal Article] Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway2013
- Author(s)
  Ohkuni A, Ohno Y, Kihara A
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 442 Issue: 3-4 Pages: 195-201
- DOI
  10.1016/j.bbrc.2013.11.036
- NAID
  120005385315
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116701
[Journal Article] Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation2013
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Genes Cells
  
  Volume: 18 Issue: 8 Pages: 650-659
- DOI
  10.1111/gtc.12062
- NAID
  120005367401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-25440038
[Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 33 Issue: 14 Pages: 2787-2796
- DOI
  10.1128/mcb.00192-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249058, KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-25670494
[Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation2013
- Author(s)
  Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 6 Pages: e67317-e67317
- DOI
  10.1371/journal.pone.0067317
- NAID
  120005322424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Identification of residues important for the catalysis, structure maintenance, and substrate specificity of yeast 3-hydroxyacyl-CoA dehydratase Phs12013
- Author(s)
  Yazawa T, Naganuma T, Yamagata M, Kihara A
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Issue: 6 Pages: 804-809
- DOI
  10.1016/j.febslet.2013.02.006
- NAID
  120005228604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] 生理活性脂質とは2012
- Author(s)
  木原章雄
- Journal Title
  
  臨床検査
  
  Volume: 56 Pages: 107-116
- Data Source
  KAKENHI-PUBLICLY-23116501
[Journal Article] A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells2012
- Author(s)
  Sassa T, Suto S, Okayasu Y, Kihara A
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1821 Issue: 7 Pages: 1031-1037
- DOI
  10.1016/j.bbalip.2012.04.008
- NAID
  120005946698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Sphingolipids regulate the yeast high osmolarity-responsive HOG pathway2012
- Author(s)
  Tanigawa M, Kihara A, Terashima M, Takahara T, Maeda T
- Journal Title
  
  Mol. Cell. Biol
  
  Volume: 32 Issue: 14 Pages: 2861-2870
- DOI
  10.1128/mcb.06111-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-23651233
[Journal Article] Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae2012
- Author(s)
  Obara, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 46 Pages: 38473-38481
- DOI
  10.1074/jbc.m112.394205
- NAID
  120005090608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657120, KAKENHI-PROJECT-23770135, KAKENHI-PROJECT-24770182
[Journal Article] Very long-chain fatty acids : elongation, physiology and related disorders2012
- Author(s)
  Kihara A
- Journal Title
  
  J. Biochem.
  
  Volume: 152 Issue: 5 Pages: 387-395
- DOI
  10.1093/jb/mvs105
- NAID
  10031166154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] The fatty aldehyde dehydrogenase ALDH3A2 is involved in the sphingosine 1-phosphate metabolic pathway2011
- Author(s)
  Kihara, A.
- Journal Title
  
  Chem.Phys.Lipids
  
  Volume: 164 Pages: S32-S32
- DOI
  10.1016/j.chemphyslip.2011.05.103
- Data Source
  KAKENHI-PUBLICLY-23116501
[Journal Article] Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae2011
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 410 Issue: 4 Pages: 786-791
- DOI
  10.1016/j.bbrc.2011.06.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-23770135
[Journal Article] Involvement of sphingolipids in autophagy in Saccharomyces cerevisiae2011
- Author(s)
  Yamagata M, Obara K, Kihara A
- Journal Title
  
  Chem. Phys. Lipids
  
  Volume: 164 Pages: S34-S35
- DOI
  10.1016/j.chemphyslip.2011.05.110
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Biochemical characterization of the very long-chain fatty acid elongase ELOVL72011
- Author(s)
  Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Issue: 20 Pages: 3337-3341
- DOI
  10.1016/j.febslet.2011.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients.2010
- Author(s)
  Konishi, H., Okuda, A., Ohno, Y., Kihara, A.
- Journal Title
  
  J.Biochem. 148
  
  Pages: 617-622
- NAID
  10027879523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Hetero-oligomeric interactions of an ELOVL4 mutant protein : implications in the molecular mechanism of Stargardt-3 macular dystrophy2010
- Author(s)
  Okuda A, Kihara A, et al.
- Journal Title
  
  Mol.Vision
  
  Volume: 16 Pages: 2438-2445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Hetero-oligomeric interactions of an ELOVL4 mutant protein : implications in the molecular mechanism of Stargardt-3 macular dystrophy.2010
- Author(s)
  Okuda, A., Naganuma, T., Ohno, Y., Abe, K., Yamagata, M., Igarashi, Y., Kihara, A.
- Journal Title
  
  Mol.Vis. 16
  
  Pages: 2438-2445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] 脂肪酸の多彩な代謝,生理機能と関連疾患2010
- Author(s)
  木原章雄
- Journal Title
  
  生化学 82
  
  Pages: 591-605
- NAID
  10026607547
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis2010
- Author(s)
  Ohno Y, Kihara A, et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 18439-18444
- NAID
  120002934261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients2010
- Author(s)
  Konishi H, Kihara A, et al.
- Journal Title
  
  J.Biochem.
  
  Volume: 148 Pages: 617-622
- NAID
  10027879523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.2010
- Author(s)
  Ohno, Y., Suto, S., Yamanaka, M., Mizutani, Y., Mitsutake, S., Igarashi, Y., Sassa, T., Kihara, A.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 107
  
  Pages: 18439-18444
- NAID
  120002934261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Ceramide biosynthesis in keratinocyte and its role in skin function.2009
- Author(s)
  Mizutani, Y., Mitsutake, S., Tsuji, K., Kihara, A., Igarashi, Y.
- Journal Title
  
  Biochimie 91
  
  Pages: 784-790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, Denpoh A, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell 19(5)
  
  Pages: 1922-1931
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation.2008
- Author(s)
  Kihara, A., Sakuraba, H., Ikeda, M., Denpoh, A., Igarashi, Y.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 11199-11209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.2008
- Author(s)
  Ikeda, M., Kanao, Y., Yamanaka, M., Sakuraba, H., Mizutani, Y., Igarashi, Y., Kihara, A.
- Journal Title
  
  FEBS Lett. 582
  
  Pages: 2435-2440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation.2008
- Author(s)
  Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y.
- Journal Title
  
  J. Biol. Chem. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, Denpoh A, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The Rim101 pathway is involved in Rsbl expression induced by altered lipid asymmetry2008
- Author(s)
  Ikeda M, Kihara A, DenpohA, Igarashi Y.
- Journal Title
  
  Mol. Biol. Cell 19(5)
  
  Pages: 1922-1931
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation.2008
- Author(s)
  Kihara A.
- Journal Title
  
  The Journal of Biological Chemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17687011
[Journal Article] Membrane topology and essential amino acid residues of Phsl, a 3-hydroxyacylCoA dehydratase involved in very long-chain fatty acid elongation2008
- Author(s)
  Kihara A.
- Journal Title
  
  The Journal of Biological Chemistry 283
  
  Pages: 11199-11209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] 2-Hydroxy-ceramide synthesis by ceramide synthase family : enzymatic basis for the preference of FA chain length.2008
- Author(s)
  Mizutani, Y., Kihara, A., Chiba, H., Tojo, H., Igarashi, Y.
- Journal Title
  
  J.Lipid Res. 49
  
  Pages: 2356-2364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Journal Article] Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation2008
- Author(s)
  Kihara A, Sakuraba H, Ikeda M, Denpoh A, Igarashi Y.
- Journal Title
  
  J. Biol. Chem (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The immunomodulator FTY720 is phosphorylated and released from platelets.2007
- Author(s)
  Anada Y, Igarashi Y, Kihara A.
- Journal Title
  
  Eur J Pharm. 30;568(1-3)
  
  Pages: 106-111
- NAID
  120000970269
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphoryl ceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.2007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem. 23;282(12)
  
  Pages: 8613-8621
- NAID
  120000969952
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res. Mar; 46(2)
  
  Pages: 126-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] スフィンゴ脂質の生理活性と代謝調節2007
- Author(s)
  五十嵐靖之、木原章雄
- Journal Title
  
  バイオとナノの融合II 新生命科学の応用北海道大学COE研究成果編集委員会編
  
  Pages: 117-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. May25;357(1)
  
  Pages: 212-217
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/Iysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res. Jul 15;313(12)
  
  Pages: 2651-2666
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.2007
- Author(s)
  Iwaki S, Sano T, Takagi T, Osumi M, Kihara A, and Igarashi Y
- Journal Title
  
  J. Biol. Chem. vol.282 no.39
  
  Pages: 28485-28492
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma SIP in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 357(1)
  
  Pages: 212-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] スフィンゴ脂質の生理活性と代謝調節2007
- Author(s)
  五十嵐靖之、木原章雄
- Journal Title
  
  バイオとナノの融合II新生命科学の応用北海道大学COE研究成果編集委員会編
  
  Pages: 117-131
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res 46(2)
  
  Pages: 126-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res. 0715;313(12)
  
  Pages: 2651-2666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets.2007
- Author(s)
  Ito K, Anada Y, Tani M, Ikeda M, Sano T, Kihara A, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun. May 25;357(1)
  
  Pages: 212-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphoryl ceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg22007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem. 23;282(12)
  
  Pages: 8613-8621
- NAID
  120000969952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomesllysosomes.2007
- Author(s)
  Kasahara K, Nakayama Y, Kihara A, Matsuda D, Ikeda K, Kuga T, Fukumoto Y, Igarashi Y, Yamaguchi N.
- Journal Title
  
  Exp. Cell Res 313(12)
  
  Pages: 2651-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.2007
- Author(s)
  Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.
- Journal Title
  
  Prog. Lipid Res. Mar;46(2)
  
  Pages: 126-44
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation.2007
- Author(s)
  Iwaki S, Sano T, Takagi T, Osumi M, Kihara A, and Igarashi Y.
- Journal Title
  
  J. Biol. Chem 282(39)
  
  Pages: 28485-28492
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csgl and Cshl by the Ca2+-binding protein Csg2.2007
- Author(s)
  Uemura S, Kihara A, Iwaki S, Inokuchi JI, Igarashi Y.
- Journal Title
  
  J Biol Chem 282(12)
  
  Pages: 8613-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] The immunomodulator FTY720 is phosphorylated and released from platelets.2007
- Author(s)
  Anada Y, Igarashi Y, KiharaA.
- Journal Title
  
  Eur J Pharm 568(1-3)
  
  Pages: 106-11
- NAID
  120000970269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization2006
- Author(s)
  Kihara , et. al.
- Journal Title
  
  The Journal of Biological Chemistry 281・7
  
  Pages: 4532-4539
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Mouse sphingosine kinase isoforms SPHK1a and SPHKIb differ in enzymatic traits including stability, localization, modification, and oligomerization.2006
- Author(s)
  Kihara A, Anada Y, Igarashi Y.
- Journal Title
  
  J Biol Chem 281(7)
  
  Pages: 4532-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] LASS3 is a testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.2006
- Author(s)
  Mizutani Y, KiharaA, Igarashi Y.
- Journal Title
  
  Biochem. J 398(3)
  
  Pages: 531-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.2006
- Author(s)
  Ohno Y, Kihara A, Sano T, Igarashi Y.
- Journal Title
  
  Biochim Biophys Acta 1761(4)
  
  Pages: 474-83
- NAID
  120000959467
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization2006
- Author(s)
  Kihara, et al.
- Journal Title
  
  The Journal of Biological Chemistry 281・7
  
  Pages: 4532-4539
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.2006
- Author(s)
  Kobayashi N, Nishi T, Hirata T, Kihara A, Sano T, Igarashi Y, Yamaguchi A.
- Journal Title
  
  J Lipid Res 47(3)
  
  Pages: 614-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Changes in SIP1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.2006
- Author(s)
  HiragaY, KiharaA, Sano T, Igarashi Y.
- Journal Title
  
  Biochem Biophys Res Commun 344(3)
  
  Pages: 852-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Journal Article] Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization2006
- Author(s)
  Kihara et al.
- Journal Title
  
  The Journal of Biological Chemistry 281・7
  
  Pages: 4532-4539
- Data Source
  KAKENHI-PROJECT-17687011
[Journal Article] Long-chain base kinase Lcb4 is anchored to the membrane through its palmitoylation by Akrl2005
- Author(s)
  Kihara et al.
- Journal Title
  
  Molecular and Cellular Biology 25・21
  
  Pages: 9189-9197
- Data Source
  KAKENHI-PROJECT-17687011
[Journal Article] FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane2004
- Author(s)
  Kihara, A., Igarashi, Y.
- Journal Title
  
  The Journal of Biological Chemistry 279・47
  
  Pages: 49243-49250
- Data Source
  KAKENHI-PROJECT-15770078
[Journal Article] Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry2004
- Author(s)
  Kihara A.
- Journal Title
  
  Mol.Biol.Cell 15(11)
  
  Pages: 4949-4959
- Data Source
  KAKENHI-PROJECT-12140201
[Journal Article] Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry2004
- Author(s)
  Kihara, A., Igarashi, Y.
- Journal Title
  
  Molecular Biology of the Cell 15・11
  
  Pages: 4949-4959
- Data Source
  KAKENHI-PROJECT-15770078
[Journal Article] FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic Reticulum Membrane.2004
- Author(s)
  Kihara A.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 49243-49250
- Data Source
  KAKENHI-PROJECT-12140201
[Journal Article] Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm2003
- Author(s)
  Kihara A. et al.
- Journal Title
  
  The Journal of Biological Chemistry 278・16
  
  Pages: 14578-14585
- Data Source
  KAKENHI-PROJECT-15770078
[Presentation] Skin permeability barrier formation by ceramides2023
- Author(s)
  Kihara Akio
- Organizer
  The 11th Annual Congress of Pan Asian-Pacific Skin Barrier Research Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] Formation of skin permeability barrier by diverse ceramides2023
- Author(s)
  Kihara Akio
- Organizer
  29th annual meeting of Korean Society of Skin Barrier Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 角質層の遊離セラミド組成と皮膚の乾燥・外観指標との相関解析2023
- Author(s)
  高橋夏海, 秋山史成, 上田悠人, 多田静乃, 竹内伸之, 大野祐介, 木原章雄
- Organizer
  第16回セラミド研究会学術集会，第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 多様なセラミドによる皮膚透過性バリア形成2023
- Author(s)
  木原章雄
- Organizer
  第2回アトピー性皮膚炎とバリア機能について考える会
- Invited
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] SREBF1変異を有する先天性魚鱗癬IFAP症候群患者の角質層脂質組成解析2023
- Author(s)
  水野佑香, 城島啓佑, 滝奉樹, 武市拓也, 秋山真志, 木原章雄
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 先天性魚鱗癬IFAP症候群患者の角質層脂質組成解析2023
- Author(s)
  水野佑香, 城島啓佑, 滝奉樹, 武市拓也, 秋山真志, 木原章雄
- Organizer
  日本薬学会北海道支部150回例会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] Molecular mechanism of permeability barrier formation by ceramides2023
- Author(s)
  Kihara Akio
- Organizer
  2023 International BioLipids Interactomics Research Center annual symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 神経系における長鎖脂肪族アルコール産生酵素FAR1の機能2023
- Author(s)
  髙橋典雅, 大塚賢人, 佐々貴之, 木原章雄
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 口腔バリア形成へのセラミドの関与2023
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第16回セラミド研究会学術集会，第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 表皮結合型セラミドの構造決定：マイケル付加反応により産生されるシステイン結合型セラミド2023
- Author(s)
  大野祐介, 中村哲也, 勝山彬, 市川聡, 木原章雄
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] ELOVL4ミスセンス変異による脊髄小脳失調症34型における超長鎖多価不飽和脂肪酸の不完全伸長2023
- Author(s)
  田村優花, 佐々貴之, 西澤卓海, 木原章雄
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] セラミド不飽和化酵素FADS3の基質特異性とスフィンガジエンの代謝2023
- Author(s)
  城島啓佑, 木原章雄
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 皮膚バリア形成に重要な結合型セラミドの構造決定2023
- Author(s)
  大野祐介, 中村哲也, 岩崎貴文, 勝山彬, 市川聡, 木原章雄
- Organizer
  第16回セラミド研究会学術集会，第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 表皮におけるフィトセラミドの産生機構とDEGS2の基質特異性の解明2022
- Author(s)
  森田洋哉, 太田愛, 野尻光希, 城島啓佑, 木原章雄
- Organizer
  日本薬学会北海道支部149回例会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] セミノリピド合成と精子形成における脂肪族アシルCoA還元酵素Far1の役割2022
- Author(s)
  玉澤彩乃, 大塚賢人, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 表皮フィトセラミド産生におけるDEGS2の寄与と水酸化・不飽和化の二機能活性における基質特異性の違い2022
- Author(s)
  森田洋哉, 太田愛, 宮本政宗, 城島啓佑, 野尻光希, 永沼達郎, 松田純子, 木原章雄
- Organizer
  第15回セラミド研究会学術集会，第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 脂肪酸伸長酵素ELOVLにより産生される極長鎖脂肪酸の多様な機能2022
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 魚鱗癬原因遺伝子Nipal4欠損マウス表皮におけるセラミド組成解析2022
- Author(s)
  山地まりの, 大野祐介, 木原章雄
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] Comprehensive analysis of human stratum corneum ceramides by LC-MS/MS-based targeted lipidomics.2022
- Author(s)
  Ohno Y, Suzuki M, Kawana M, Kihara A.
- Organizer
  10th International Singapore Lipid Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] セラミド不飽和化酵素FADS3の基質特異性と4,14-スフィンガジエンの代謝2022
- Author(s)
  城島啓佑, 木原章雄
- Organizer
  第15回セラミド研究会学術集会，第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] ヒト三次元培養表皮を用いた結合型セラミド組成解析と肌機能評価への活用2022
- Author(s)
  秋山史成, 井野口友紀, 大塚彩加, 竹内伸之, 大野祐介, 木原章雄, 高岡彰子
- Organizer
  第15回セラミド研究会学術集会，第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 皮膚バリアの維持におけるアシルセラミド及び結合型セラミドの役割2022
- Author(s)
  平沼大雅, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] LC-MS/MSを用いたターゲットリピドミクスによるヒト角質層セラミド分子種の包括的解析2022
- Author(s)
  大野祐介, 鈴木まどか, 川名桃子, 木原章雄
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] トランス-2-エノイルCoA還元酵素Tsc13/TECRの触媒残基の同定と脂肪酸縮合反応に対する促進作用2022
- Author(s)
  竹中優佳, 加藤稜也, 大野祐介, 木原章雄
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] LIPN変異による魚鱗癬発症メカニズムの解明2022
- Author(s)
  白井綜, 城島啓佑, 大野祐介, 木原章雄
- Organizer
  日本薬学会北海道支部149回例会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] 2-水酸化スフィンゴ脂質から奇数鎖スフィンゴ脂質を生み出すα酸化の分子機構2022
- Author(s)
  毛利圭佑, 永沼達郎, 木原章雄
- Organizer
  第15回セラミド研究会学術集会，第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-22H04986
[Presentation] スフィンガジエン中のシス二重結合形成に関わるFADS3の同定2021
- Author(s)
  城島啓佑, 木原章雄
- Organizer
  第20回次世代を担うファーマ・バイオフォーラム2021
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 長鎖塩基鎖長の多様性を含めたヒト角質層セラミドの包括的解析2021
- Author(s)
  鈴木まどか, 大野祐介, 木原章雄
- Organizer
  第14回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシルセラミド／結合型セラミドは口腔粘膜上皮の物質透過性バリア形成に関わる2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第14回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 皮膚バリア脂質アシルセラミド／結合型セラミドの口腔および食道の粘膜上皮における存在と機能2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] スフィンガジエン含有スフィンゴ脂質の生合成と代謝機構の解明2021
- Author(s)
  城島啓佑, 澤井恵, 木原章雄
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 鱗癬原因遺伝子Nipal4欠損によるマウス表皮の脂質組成変化2021
- Author(s)
  山地まりの, 大野祐介, 木原章雄
- Organizer
  第14回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 脂肪酸ω-水酸化酵素CYP4F22及びトランスアシラーゼPNPLA1の魚鱗癬変異による皮膚バリア脂質アシルセラミド産生への影響2021
- Author(s)
  野原知博, 大野祐介, 木原章雄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシルセラミド／結合型セラミドによる口腔粘膜上皮バリア形成2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] ヒト角質層セラミドの長鎖塩基鎖長の多様性2021
- Author(s)
  鈴木まどか, 大野祐介, 木原章雄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] セラミドの多様性と皮膚バリア機能2021
- Author(s)
  木原章雄
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 哺乳類セラミドの多様性を生み出す分子機構2020
- Author(s)
  木原章雄
- Organizer
  第14回スフィンゴテラピィ研究会
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] 脂肪族アシルCoA還元酵素FAR2による極長鎖アルコールの産生とドライアイ防止における役割2020
- Author(s)
  大塚賢人, 澤井恵, 木原章雄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシルCoA還元酵素FAR2による極長鎖脂肪族アルコール産生とドライアイ防止2020
- Author(s)
  大塚賢人, 澤井恵, 木原章雄
- Organizer
  日本薬学会北海道支部147回例会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 哺乳類セラミドの多様性を生み出す分子機構2020
- Author(s)
  木原章雄
- Organizer
  第14回スフィンゴテラピィ研究会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] セラミドの多様性と皮膚透過性バリア機能2020
- Author(s)
  木原章雄
- Organizer
  第13回セラミド研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 魚鱗癬を引き起こすセラミド合成酵素CERS3変異の活性および角質層セラミド組成への影響2020
- Author(s)
  山本萌恵, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部147回例会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] ω水酸化脂質による涙液油層中の極性勾配形成がドライアイを防止する2020
- Author(s)
  宮本政宗, 佐々貴之, 澤井恵, 木原章雄
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシル基転移酵素Awat1および2が生み出す多様なエステル分子種と涙液油層における役割2020
- Author(s)
  澤井恵, 大塚賢人, 宮本政宗, 丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 魚鱗癬を引き起こすセラミド合成酵素CERS3変異の活性および角質層セラミド組成への影響2020
- Author(s)
  山本萌恵, 佐々貴之, 京野由紀, 上村裕保, 久呉真章, 林秀樹, 今井康友, 山西清文, 木原章雄.
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシルCoA還元酵素FAR2による極長鎖脂肪族アルコールの産生とドライアイ防止における役割2020
- Author(s)
  大塚賢人, 澤井恵, 木原章雄
- Organizer
  第19回次世代を担うファーマ・バイオフォーラム2020
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] シス二重結合を有するスフィンガジエン含有スフィンゴ脂質の生合成と機能2020
- Author(s)
  城島啓佑, 枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 極長鎖分岐鎖脂肪酸の伸長と代謝及び組織分布の解明2020
- Author(s)
  丹野歩乃佳, 佐々貴之, 澤井恵, 木原章雄
- Organizer
  第19回次世代を担うファーマ・バイオフォーラム2020
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 新規ELOVL1変異を持つ魚鱗癬患者の角質層の包括的セラミドプロファイリング2020
- Author(s)
  高橋多衣子, 佐々貴之, 木原章雄
- Organizer
  第13回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] ジヒドロセラミドの水酸化と不飽和化を担う二機能酵素DEGS2の反応に依存した鎖長の特異性2020
- Author(s)
  太田愛, 城島啓佑, 宮本政宗, 木原章雄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 脂肪酸ω-水酸化酵素遺伝子変異によるアシルセラミド産生低下と魚鱗癬病態との関連2020
- Author(s)
  野原知博, 宮本政宗, 大野祐介, 木原章雄
- Organizer
  日本薬学会北海道支部147回例会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] アシルCoA合成酵素FATP4／ACSVL4は皮膚バリア脂質アシルセラミドの合成に関与する2019
- Author(s)
  山本春佳, 服部未来, 大野祐介, 木原章雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] シス二重結合をもつ長鎖塩基4,14-スフィンガジエンの広範な哺乳類組織分布と代謝2019
- Author(s)
  城島啓佑, 枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Acylceramide production and skin barrier formation by the fatty acid omega-hydroxylase CYP4F22/Cyp4f392019
- Author(s)
  Itoh N, Ohno Y, Sassa T, Kihara A
- Organizer
  FEBS Special Meeting on Sphingolipid Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Decreases in chain lengths and level of myelin sphingolipids are associated with hypomyelination and deficient motor coordination in mice lacking fatty acid elongase ELOVL12019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  第42回日本神経科学大会／第62回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] スフィンガジエンの組織分布，代謝，機能及び，生合成経路の解明2019
- Author(s)
  城島啓佑, 枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  日本薬学会北海道支部146回例会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Acylceramide production and skin barrier formation by the fatty acid omega-hydroxylase CYP4F22/Cyp4f392019
- Author(s)
  Itoh N, Ohno Y, Sassa T, Kihara A
- Organizer
  FEBS Special Meeting on Sphingolipid Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] 分岐鎖脂肪酸の伸長と組織分布の解明2019
- Author(s)
  丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部146回例会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Very long-chain lipids produced by the fatty acid elongase ELOVL1 are important for myelin formation and motor coordination2019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] スフィンゴシン1-リン酸のリン脂質ホスファターゼ非依存的な取り込み機構2019
- Author(s)
  後藤大空, 宮本政宗, 木原章雄
- Organizer
  第12回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Decreases in chain lengths and level of myelin sphingolipids are associated with hypomyelination and deficient motor coordination in mice lacking fatty acid elongase ELOVL12019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  第42回日本神経科学大会／第62回日本神経化学会大会
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] Very long-chain lipids produced by the fatty acid elongase ELOVL1 are important for myelin formation and motor coordination2019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] スフィンガジエン含有スフィンゴ脂質の生合成経路の解明2019
- Author(s)
  枝川茉生, 城島啓佑, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第12回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] LC-MS/MSを用いた測定によるヒトおよびマウス角質層セラミドプロファイルのアップデート2019
- Author(s)
  川名桃子, 宮本政宗, 大野祐介, 木原章雄
- Organizer
  第12回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 分岐鎖脂肪酸の伸長酵素および組織分布の解明2019
- Author(s)
  丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Molecular mechanism producing the skin barrier lipid acylceramide2019
- Author(s)
  Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] シェーグレン・ラルソン症候群皮膚病態モデルマウスの確立と病態発症機構の解明2019
- Author(s)
  野尻光希, 筆谷周平, 佐々貴之, 木原章雄
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Establishment of Sjogren-Larsson syndrome model mouse leading to elucidation of the skin pathogenesis mechanism2019
- Author(s)
  Nojiri K, Fudetani S, Sassa T, Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 皮膚バリア脂質アシルセラミドの合成経路と魚鱗癬病態の分子機構の解明2018
- Author(s)
  木原章雄
- Organizer
  第42回蛋白質と酵素の構造に関する九州シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] A decrease in 2-hydroxygalactosylceramide in the brain of the Sjogren-Larsson syndrome gene knockout mice2018
- Author(s)
  Kanetake T, Sassa T, Nojiri K, Kihara A
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Long-chain base metabolism and α-oxidation in the ER2018
- Author(s)
  Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 哺乳類におけるスフィンガジエン含有スフィンゴ脂質の組織分布と代謝2018
- Author(s)
  城島啓佑, 枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Impaired fatty aldehyde oxidation in a gene knockout mouse model of Sjogren-Larsson syndrome is associated with behavioral abnormalities and reduced myelin 2-hydroxygalactosylceramide levels2018
- Author(s)
  Sassa T, Kanetake T, Nojiri K, Kihara A
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] 脳ミエリンにおける脂肪酸伸長酵素ELOVL1の機能解析2018
- Author(s)
  磯川昌志, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部145回例会
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] Very long-chain lipids as barrier lipids at the body surface2018
- Author(s)
  Sassa T, Kihara A
- Organizer
  2nd Japan-Korea Lipid Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] シェーグレン・ラルソン症候群モデルマウスの神経症状とミエリンにおける2-水酸化ガラクトシルセラミドの減少2018
- Author(s)
  佐々貴之, 金武司, 野尻光希, 澤井恵, 北村拓也, 木原章雄
- Organizer
  第11回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] スフィンガジエン含有スフィンゴ脂質の組織分布と代謝の解明2018
- Author(s)
  枝川茉生, 城島啓佑, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第11回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] Skin analysis using knockout mice of phytoceramide producing gene Degs2: discovery of novel ceramide species2018
- Author(s)
  Miyamoto M, Kitamura T, Sawai M, Kihara A
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664
[Presentation] Skin analysis using knockout mice of phytoceramide producing gene Degs2: discovery of novel ceramide species2018
- Author(s)
  Miyamoto M, Kitamura T, Sawai M, Kihara A
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03976
[Presentation] ABHD5 stimulates acylceramide synthesis by recruiting PNPLA1 to lipid droplets2018
- Author(s)
  Ohno Y, Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群モデルマウスにおけるミエリン脂質2-ヒドロキシガラクトシルセラミドの低下2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム2017
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ミオパチー原因遺伝子HACD1の生理機能と基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 新規セラミド分子種：β水酸化脂肪酸含有セラミドの同定2017
- Author(s)
  宮本政宗, 北村拓也, 澤井恵, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子NIPAL4の欠損によるアシルセラミド産生低下と皮膚バリア機能異常2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム2017
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Skin barrier formation by acylceramide2017
- Author(s)
  Kihara A
- Organizer
  Hokkaido University - Korean Society for Molecular and Cellular Biology Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] C24:2多価不飽和スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  第10回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] マウス表皮における水酸化セラミドの解析とジヒドロセラミドC-4水酸化酵素（DEGS2）の関与2017
- Author(s)
  宮本政宗, 北村拓也, 関直哉, 澤井恵, 松田純子, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 多価不飽和脂肪酸含有スフィンゴ脂質の組織分布及び生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第54回支部例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 哺乳類におけるC24:2多価不飽和脂肪酸含有スフィンゴ脂質の存在と生合成経路の解明2017
- Author(s)
  枝川茉生, 澤井恵, 大野祐介, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸2位水酸化酵素FA2H機能低下によるシェーグレン・ラルソン症候群の神経症状発症2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] マウスCYP4F39による超長鎖脂肪酸のω位水酸化はアシルセラミド産生および皮膚バリア形成に必須である2017
- Author(s)
  伊藤成美, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂質による体表面バリア形成機構と病態2017
- Author(s)
  木原章雄
- Organizer
  九州大学公開講演会　最新化学談話シリーズ　平成29年度第1回談話会
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 極長鎖脂肪酸／脂肪族アルコール含有マイバム脂質は涙液のバリア機能に必須である2017
- Author(s)
  佐々貴之, 只木雅人, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア脂質アシルセラミド生合成経路の全容解明2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア脂質アシルセラミド合成におけるトランスアシラーゼPNPLA1の同定とABHD5の関与2017
- Author(s)
  大野祐介, 中路翔太, 神山望, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] スフィンゴ脂質代謝酵素の同定と脂質修飾による調節2017
- Author(s)
  木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸伸長サイクル不全によるミオパチー発症の分子機構およびHACDの基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子Nipal4ノックアウトマウスにおける皮膚バリア脂質アシルセラミドの減少2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群の神経症状発症メカニズムの解明2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第54回支部例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸2位水酸化酵素FA2H機能低下によるシェーグレン・ラルソン症候群の神経症状発症2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Decrease in 2-hydroxygalactosylceramide and impairment in behavioral tests in Aldh3a2 knockout mice2016
- Author(s)
  Sassa T, Kanetake T, Takagi S, Nojiri K, Naganuma T, Kitamura T, Kihara A
- Organizer
  57th International Conference on the Bioscience of Lipids
- Place of Presentation
  シャモニー（フランス）
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] フィトスフィンゴシン分解に関わる新規哺乳類アルファ酸化経路2016
- Author(s)
  北村拓也, 関直哉, 木原章雄
- Organizer
  第9回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都中央区）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] アシルCoA合成酵素ACSVL4はアシルセラミド合成に関与する2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Retarded skin barrier recovery and an increased keratinocyte growth in Sjogren-Larsson syndrome gene Aldh3a2 knockout mice2016
- Author(s)
  Naganuma T, Takagi S, Kanetake T, Kitamura T, Sassa T, Kihara A
- Organizer
  1st Korea-Japan Bioactive Lipid Joint Symposium
- Place of Presentation
  チェジュ（韓国）
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Human CYP4F22 in production of acylceramide for skin permeability barrier formation2016
- Author(s)
  Kihara A
- Organizer
  21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  デービス（アメリカ）
- Year and Date
  2016-10-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] セラミド多様性の分子機構2016
- Author(s)
  木原章雄
- Organizer
  第9回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都中央区）
- Year and Date
  2016-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂質に由来する脂肪族アルデヒドの代謝酵素：ALDH3ファミリーの解析2016
- Author(s)
  北村拓也, 木原章雄
- Organizer
  第11回スフィンゴテラピィ研究会
- Place of Presentation
  ホテルアローレ（石川県河北郡）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] セラミド合成酵素CERS2-6のリン酸化による活性制御2016
- Author(s)
  佐々貴之, 平山泰佑, 原田由貴, 木原章雄
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田市にぎわい交流館AU（秋田県秋田市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群モデルマウスを用いた病態のメカニズム解析2016
- Author(s)
  木原章雄, 永沼達郎, 金武司, 佐々貴之
- Organizer
  第11回スフィンゴテラピィ研究会
- Place of Presentation
  ホテルアローレ（石川県河北郡）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Identification of genes involved in epidermal acylceramide production2016
- Author(s)
  Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Place of Presentation
  ルッカ（イタリア）
- Year and Date
  2016-03-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Identification of the genes responsible for the synthesis of acylceramide, an essential ceramide class for skin barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  Gordon Research Conference on Glycolipid & Sphingolipid Biology
- Place of Presentation
  ルッカ（イタリア）
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Identification of human CYP4F22 as an ultra-long-chain fatty acid-specific omega-hydroxylase responsible for the synthesis of acylceramide, an essential lipid for skin permeability barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  デービス（アメリカ）
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 涙液バリア形成に必須なマイバム脂質産生の分子機構の解明2016
- Author(s)
  只木雅人, 佐々貴之, 木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 表皮アシルセラミド合成におけるアシルCoA合成酵素ACSVL4の機能解析2016
- Author(s)
  服部未来, 大野祐介, 木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Epidermal acylceramide: production mechanism and importance in skin barrier formation2016
- Author(s)
  Ohno Y, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  1st Korea-Japan Bioactive Lipid Joint Symposium
- Place of Presentation
  チェジュ（韓国）
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ドライアイ防止に関わるマイバム脂質の産生機構の解明2016
- Author(s)
  只木雅人, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] セラミドによる皮膚バリア形成の分子機構と病態2016
- Author(s)
  木原章雄
- Organizer
  第41回日本薬学会関東支部学術講演会
- Place of Presentation
  日本薬学会長井記念館（東京都渋谷区）
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 遺伝子欠損マウスを用いた魚鱗癬原因遺伝子NIPAL4/ICHTHYINの皮膚バリア形成における機能解析2016
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 木原章雄
- Organizer
  第9回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都中央区）
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア形成に必須なアシルセラミドの合成に関与する遺伝子の同定2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  日本生化学会北海道支部第52回支部例会
- Place of Presentation
  北海道大学フロンティア応用科学研究棟鈴木章ホール（北海道札幌市）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 超高質量分解能イメージング質量分析装置によるスフィンゴミエリン分子種の組織内分布可視化に関する検討2015
- Author(s)
  杉本正志, 志水陽一, 若林雅人, 吉岡健, 東野賢一, 沼田義人, 酒井祥太, 木原章雄, 五十嵐靖之, 久下裕司
- Organizer
  第10回分子イメージング学会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリアに重要なアシルセラミドの産生におけるCYP4F22の機能解析2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  日本薬学会北海道支部142回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Regulation of mammalian ceramide synthases by phosphorylation2015
- Author(s)
  Sassa T, Hirayama T, Kihara A
- Organizer
  International Conference of the Korean Society for Molecular and Cellular Biology 2015
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Ceramide metabolism and skin barrier formation2015
- Author(s)
  Kihara A
- Organizer
  niversitInternational Conference of Chung-Ang Uy on Life Science and Medical Reseach
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-09-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Metabolism, function in skin barrier formation, and pathology of ceramide2015
- Author(s)
  Kihara A
- Organizer
  International Conference of the Korean Society for Molecular and Cellular Biology 2015
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-09-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリアを形成するアシルセラミドの合成経路解明2015
- Author(s)
  大野祐介, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] リン酸化によるセラミド合成酵素の活性制御2015
- Author(s)
  佐々貴之, 平山泰祐, 木原章雄
- Organizer
  第8回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子産物PNPLA1はアシルセラミドの生合成に関与している2015
- Author(s)
  神山望, 大野祐介, 中路翔太, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Molecular mechanism of the production of acylceramide, the key lipid for skin barrier formation2015
- Author(s)
  Kihara A
- Organizer
  8th International Ceramide Conference (iCC8)/ 11th Sphingolipid Club (SLC) Joint Meeting
- Place of Presentation
  イズミール（トルコ）
- Year and Date
  2015-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Molecular mechanism generating acylceramide essential for skin barrier2015
- Author(s)
  Kihara A
- Organizer
  第10回スフィンゴテラピィ研究会
- Place of Presentation
  ホテルアローレ（石川県河北郡）
- Year and Date
  2015-06-16
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬の原因遺伝子産物PNPLA1はアシルセラミド合成に関与する2015
- Author(s)
  大野祐介, 神山望, 木原章雄
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Molecular imaging of tissue distribution of sphingomyelin species produced by particular ceramide synthase and sphingomyelin synthase2015
- Author(s)
  Sugimoto M, Shimizu Y, Wakabayashi M, Yoshioka T, Tanaka Y, Higashino K, Numata Y, Sakai S, Kihara A, Kuge Y, Igarashi Y
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
- Place of Presentation
  ブダペスト（ハンガリー）
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] A novel ultrahigh resolution imaging mass spectrometry visualizes distribution of sphingomyelin molecular species in the mouse tissue section2015
- Author(s)
  Sugimoto M, Shimizu Y, Wakabayashi M, Yoshioka T, Tanaka Y, Higashino K, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y
- Organizer
  8th Annual Meeting for the World Molecular Imaging Congress 2015
- Place of Presentation
  ハワイ（アメリカ）
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Biochemical analysis of the mutation for non-syndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation2015
- Author(s)
  Abe K, Wakashima T, Ohno Y, Kihara A
- Organizer
  6th International Singapore Lipid Symposium
- Place of Presentation
  シンガポール（シンガポール）
- Year and Date
  2015-11-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 皮膚バリア形成に必須なアシルセラミドの産生にシトクロームP450ファミリータンパク質CYP4F22が関与する2015
- Author(s)
  中路翔太, 大野祐介, 神山望, 木原章雄
- Organizer
  第88回日本生化学会大会／第38回日本分子生物学会年会合同大会
- Place of Presentation
  神戸ポートピアホテル／神戸国際会議場／神戸国際展示場／神戸商工会議所（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Metabolic pathways and genes involved in the synthesis and degradation of ceramides2015
- Author(s)
  Kihara A
- Organizer
  6th International Singapore Lipid Symposium
- Place of Presentation
  シンガポール（シンガポール）
- Year and Date
  2015-11-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 分子イメージングを用いたスフィンゴミエリン分子種の組織内分布と制御機構の解明2015
- Author(s)
  杉本正志, 志水陽一, 若林雅人, 吉岡健, 東野賢一, 沼田義人, 酒井祥太, 木原章雄, 五十嵐靖之, 久下裕司
- Organizer
  第8回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 表皮におけるアシルセラミド産生の分子機構の解明2015
- Author(s)
  木原章雄
- Organizer
  第8回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Year and Date
  2015-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群における皮膚魚鱗癬発症メカニズムの解析2014
- Author(s)
  永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第51回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] The fatty acid elongase ELOVL1 and the P450 family member CYP4F22 are involved in the production of epidermal acylceramide2014
- Author(s)
  Kihara A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The fatty acid elongase ELOVL1 and the P450 family member CYP4F22 are involved in the production of epidermal acylceramide2014
- Author(s)
  Kihara, A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Ventura, USA
- Year and Date
  2014-01-16
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The condensation reaction by the fatty acid elongase ELOVL6 is stimulated by the following reduction reaction by KAR in fatty acid elongation cycle2014
- Author(s)
  Naganuma T, Kihara A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Fatty acid elongase Elovl1 is essential for the synthesis of ≧C26 ceramides and epidermal permeability barrier formation2014
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] スフィンゴ脂質・極長鎖脂肪酸とバリア機能2014
- Author(s)
  木原章雄
- Organizer
  シンポジウム「分子から生命へ」
- Place of Presentation
  京都大学益川ホール（京都府京都市）
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪滴に局在する脂肪族アルデヒド脱水素酵素Aldh3b2の解析2014
- Author(s)
  北村拓也, 永沼達郎, 木原章雄
- Organizer
  日本生化学会北海道支部第51回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 脂肪滴に局在する脂肪族アルデヒド脱水素酵素Aldh3b2の解析2014
- Author(s)
  北村拓也, 永沼達郎, 木原章雄
- Organizer
  日本生化学会北海道支部第51回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PUBLICLY-25117701
[Presentation] 常染色体劣性遺伝精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘（仙台市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The cytochrome P450 4F subfamily protein CYP4F22 catalyzes omega-hydroxylation of ultra long-chain-containing ceramides in the epidermis2013
- Author(s)
  Ohno Y, Ohkuni A, Kamiyama N, Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Identification of long-chain base 1-phosphate metabolic pathway2013
- Author(s)
  Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ニセコヒルトンビレッジ（北海道）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] スフィンゴシン1－リン酸代謝経路における還元酵素の同定2013
- Author(s)
  若島健志, 安部健介, 木原章雄
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京大学本郷キャンパス（東京）
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] ユビキチン化が脂質非対称および外界アルカリ化シグナルを細胞膜上で媒介する2013
- Author(s)
  小原圭介, 木原章雄
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] 極長鎖脂肪酸伸長酵素Elovl1は表皮において層特異的な制御を受け皮膚バリアに必須の役割を果たす2013
- Author(s)
  佐々貴之, 大野祐介, 鈴木翔多朗, 乃村俊史, 秋山真志, 田口良, 清水宏, 糸原重美, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 家族性精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部140回例会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 極長鎖脂肪酸伸長酵素ELOVL6の生化学的解析2013
- Author(s)
  永沼達郎, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 皮膚アシルセラミド産生における脂肪酸伸長酵素と水酸化酵素の解析2013
- Author(s)
  木原章雄
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 皮膚アシルセラミド産生における脂肪酸伸長酵素と水酸化酵素の解析2013
- Author(s)
  木原章雄
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  札幌
- Year and Date
  2013-11-07
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] フィトスフィンゴシンの代謝経路の同定と奇数鎖脂肪酸への代謝2013
- Author(s)
  大野祐介, 近藤菜月, 山形麻旗, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 細胞膜脂質非対称センサーの同定2013
- Author(s)
  小原圭介, 山本林, 木原章雄
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインク愛知（愛知県）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] フィトスフィンゴシンは奇数鎖脂肪酸へと代謝される2013
- Author(s)
  大野祐介, 近藤菜月, 山形麻旗, 木原章雄
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘（仙台市）
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 家族性精神遅滞原因遺伝子TER P182L変異体の生化学的解析とスフィンゴ脂質代謝への影響について2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] アシルセラミドの合成に関与するシトクロムP450の同定2013
- Author(s)
  大國礼, 大野祐介, 神山望, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] リン脂質のフロップに関与する新規酵母因子Opt2の単離・解析2013
- Author(s)
  山内佐織, 小原圭介, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] 極長鎖脂肪酸の生理機能の解明2012
- Author(s)
  木原章雄
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The complete sphingosine 1-phosphate metabolic pathway involves the Sjogren-Larsson syndrome gene2012
- Author(s)
  Kihara, A.
- Organizer
  Gordon Research Conference (Glycolipid Sphingolipid Biology)
- Place of Presentation
  Renaissance Tuscany Il Ciocco Resort（イタリア）
- Year and Date
  2012-04-22
- Invited
- Data Source
  KAKENHI-PUBLICLY-23116501
[Presentation] スフィンゴシン1-リン酸の代謝経路の全容解明2012
- Author(s)
  木原章雄
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌)(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PUBLICLY-23116501
[Presentation] 極長鎖脂肪酸の皮膚バリア, 小胞輸送における役割2012
- Author(s)
  木原章雄
- Organizer
  第54回日本脂質生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] スフィンゴシン1-リン酸代謝経路の全容解明とシェーグレン・ラルソン症候群原因遺伝子の関与2012
- Author(s)
  木原章雄
- Organizer
  第5回セラミド研究会　学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都）
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PUBLICLY-23116501
[Presentation] 極長鎖脂肪酸の生理機能の解明2012
- Author(s)
  木原章雄
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場／マリンメッセ福岡（福岡県）
- Invited
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 極長鎖脂肪酸の皮膚バリア，小胞輸送における役割2012
- Author(s)
  木原章雄
- Organizer
  第54回日本脂質生化学会
- Place of Presentation
  九州大学（福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] The Sjogren-Larsson syndrome-causative gene ALDH3A2 is involved in the sphingosine 1-phosphate-metabolic pathway2011
- Author(s)
  Kihara, A.
- Organizer
  The 30th Naito Conference on Membrane Dynamics and Lipid Biology [II]
- Place of Presentation
  Chateraise Gateaux Kingdom Sapporo(北海道)
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PUBLICLY-23116501
[Presentation] スフィンゴシン1-リン酸代謝経路の解明:シェーグレン・ラルソン症候群原因遺伝子ALDH3A2の関与2011
- Author(s)
  木原章雄
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  ホテル東京ガーデンパレス(東京)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PUBLICLY-23116501
[Presentation] C24アシルCoAの産生とC24セラミド合成による制御機構2010
- Author(s)
  木原章雄
- Organizer
  第3回セラミド研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] Specificity of elongation of saturated, very long-chain fatty acids provides a link to C24 sphingolipid synthesis2010
- Author(s)
  Kihara, A.
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  ガトーキングダム札幌(北海道)(招待講演)
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] C24アシルCoAの産生とC24セラミド合成による制御機構2010
- Author(s)
  木原章雄
- Organizer
  第3回セラミド研究会学術集会
- Place of Presentation
  東京大学(東京都)(招待講演)
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] Specificity of elongation of saturated, very long-chain fatty acids provides a link to C24 sphingolipid synthesis.2010
- Author(s)
  Kihara, A.
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] 極長鎖脂肪酸の代謝経路と調節機構2010
- Author(s)
  木原章雄
- Organizer
  神戸大学医学部グローバルCOE学術講演会
- Place of Presentation
  神戸大学(兵庫県)(招待講演)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] Synthesis of very long-chain fatty acid and its relationship to sphingolipid metabolism.2009
- Author(s)
  Kihara, A., Igarashi, Y.
- Organizer
  50th International Conference on the Bioscience of Lipids
- Place of Presentation
  Regensburg, Germany
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] Metabolism and functions of sphingosine 1-phosphate and FTY720.2009
- Author(s)
  木原章雄
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学(大阪府)
- Year and Date
  2009-11-30
- Data Source
  KAKENHI-PROJECT-20659007
[Presentation] Synthesis of very long-chain fatty acid and its relationship to sphingolipid metabolism2009
- Author(s)
  Kihara A.
- Organizer
  50^<th> International Conference on the Bioscience of Lipids
- Place of Presentation
  Regensburg(ドイツ)
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] 細胞膜脂質非対称感知システムによるスフィンゴイド塩基トランスロカーゼRsb1の発現誘導機構2008
- Author(s)
  木原章雄
- Organizer
  第176回酵母細胞研究会例会
- Place of Presentation
  アサヒビール(株)本社 (東京)
- Year and Date
  2008-12-08
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] 脂質非対称変化による酵母スフィンゴイド塩基トランスロカーゼ発現誘導の分子機構2008
- Author(s)
  木原章雄
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] 免疫抑制剤FTY720の代謝と血小板からの放出2007
- Author(s)
  山中雅夫、穴田佳大、木原章雄、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)JCBL49:228-231
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] Phs1ファミリーによるホスファチジルイノシトール輸送とスフィンゴ脂質代謝に及ぼす影響、Traffikingof PI and effects on sphingolipid metabolism by Psh1 family.2007
- Author(s)
  木原章雄、五十嵐靖之
- Organizer
  第80回日本生化学会大会・第30回日本分子生物学会年会合同大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] スフィンゴシン1-リン酸受容体S1P1のパルミトイル化およびパルミトイルトランスフェラーゼDHHCファミリーの解析2007
- Author(s)
  大野祐介, 伊藤彩子、木原章雄、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)、JCBL49:30-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 出芽酵母におけるスフィンゴ糖脂質合成の調節機構2007
- Author(s)
  上村聡志, 木原章雄, 岩城壮一郎、井ノ口仁一、五十嵐靖之
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道大学(札幌)、JCBL49:103-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] Phs1ファミリーによるスフィンゴ脂質輸送・代謝調節2007
- Author(s)
  木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)JCBL48:20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] Phs1ファミリーによるホスファチジルイノシトール輸送とスフィンゴ脂質代謝に及ぼす影響2007
- Author(s)
  木原章雄
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-17687011
[Presentation] 酵母スフィンゴイド塩基キナーゼLcb4pにおいて見られる細胞膜-ER間新規輸送機構2006
- Author(s)
  岩城壮一郎、佐野孝光、高木智子、大隅正子、木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)JCBL48:271-274
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 赤血球/血小板におけるスフィンゴシン1-リン酸およびFTY720Pの生成放出機構2006
- Author(s)
  穴田佳大, 伊藤清春、谷元洋、池田未佳、佐野孝光、木原章雄、五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京),JCBL48:219-222
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] ヒトパルミトイルトランスフェラーゼDHHCファミリーの細胞内局在と組織分布2006
- Author(s)
  大野祐介, 木原章雄、佐野孝光, 五十嵐靖之
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  日本科学未来館(東京)、JCBL48:215-218
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370050
[Presentation] 長鎖塩基のグリセロ脂質への代謝経路と代謝酵素の同定
- Author(s)
  木原章雄
- Organizer
  日本植物学会第78回大会
- Place of Presentation
  明治大学生田キャンパス（神奈川県川崎市）
- Year and Date
  2014-09-12 – 2014-09-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] セラミドの合成と分解の経路・遺伝子の同定
- Author(s)
  木原章雄
- Organizer
  第9回スフィンゴテラピィ研究会
- Place of Presentation
  山中温泉河鹿荘ロイヤルホテル（石川県加賀市）
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Phytosphingosine is a source of odd-numbered fatty acids via a novel pathway involving the MPO1 gene
- Author(s)
  Kondo N, Ohno Y, Yamagata M, Nagamuma T, Kihara A
- Organizer
  6th International conference on phospholipase A2 and lipid mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 脂肪族アルデヒド脱水素酵素Aldh3bファミリーの活性と細胞内局在
- Author(s)
  北村拓也, 永沼達郎, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25117701
[Presentation] Rim21 senses alteration in plasma membrane lipid asymmetry and elicits the signal at the plasma membrane in a ubiquitination-dependent manner
- Author(s)
  Obara K, Nishino K, Kihara A
- Organizer
  FEBS-EMBO
- Place of Presentation
  パリ（フランス）
- Year and Date
  2014-08-30 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] Aldh3a2 knockout mice as a potential model for Sjogren-Larsson syndrome
- Author(s)
  Sassa T, Kanetake T, Nagamuma T, Takagi S, Kitamura T, Kihara A
- Organizer
  6th International conference on phospholipase A2 and lipid mediators
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] シェーグレン・ラルソン症候群原因遺伝子ALDH3A2の表皮における機能解析
- Author(s)
  高木秀侑, 永沼達郎, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 長鎖塩基の吸収と代謝の分子メカニズム
- Author(s)
  近藤菜月, 成田智美, 大野祐介, 永沼達郎, 木原章雄
- Organizer
  第7回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場CANVAS（東京都中央区）
- Year and Date
  2014-10-30 – 2014-10-31
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 脂肪族アルデヒド脱水素酵素Aldh3bファミリーの活性と細胞内局在
- Author(s)
  北村拓也, 永沼達郎, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の中枢神経系における機能解析
- Author(s)
  金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  日本薬学会北海道支部141回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2 KOマウスを用いた脳における生化学的解析
- Author(s)
  金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 魚鱗癬原因遺伝子CYP4F22の皮膚における生理機能解析
- Author(s)
  神山望, 大野祐介, 大國礼, 中路翔太, 木原章雄
- Organizer
  日本薬学会北海道支部141回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-05-24 – 2014-05-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の欠損はマウスケラチノサイトにおいて細胞増殖の亢進とアシルセラミド量の低下を引き起こす
- Author(s)
  永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] 表皮セラミドと長鎖塩基の代謝と生理機能
- Author(s)
  木原章雄
- Organizer
  ifia JAPAN 2014（第19回国際食品素材／添加物展・会議）
- Place of Presentation
  東京ビッグサイト（東京都江東区）
- Year and Date
  2014-05-21 – 2014-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Regulation of fatty aldehyde dehydrogenases by lipid modification
- Author(s)
  Kihara A
- Organizer
  International symposium on protein modification in pathogenic dysregulation of signaling
- Place of Presentation
  東京大学医科学研究所（東京都港区）
- Year and Date
  2015-01-23 – 2015-01-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-25117701
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2ノックアウトマウスを用いた神経症状発症の分子機構の解析
- Author(s)
  佐々貴之, 金武司, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PUBLICLY-25116701
[Presentation] リン脂質のフロップに関わる新規因子Opt2の発見
- Author(s)
  小原圭介, 山内佐織, 木原章雄
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂／東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25650059
[Presentation] パルミトイルトランスフェラーゼによる蛋白質の機能制御機構解析
- Author(s)
  大野祐介, 小潟廉, 石富暁博, 樫尾睦, 山崎勇貴, 木原章雄
- Organizer
  「修飾シグナル病」第3回若手ワークショップ
- Place of Presentation
  湯河原温泉ホテルあかね（神奈川県足柄下郡）
- Year and Date
  2014-09-30 – 2014-10-02
- Data Source
  KAKENHI-PUBLICLY-25117701
[Presentation] Identification of the cytochrome P450 4F subfamily protein CYP4F22 as a ceramide ω-hydroxylase involved in the synthesis of acylceramide in epidermis
- Author(s)
  Ohno Y, Ohkuni A, Kamiyama N, Nakamichi S, Kihara A
- Organizer
  55th International Conference on the Bioscience of Lipids
- Place of Presentation
  Aberdeen（英国）
- Year and Date
  2014-06-23 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] アシルセラミド合成に関与する超長鎖脂肪酸特異的ω水酸化酵素 CYP4F22 の同定
- Author(s)
  大野祐介, 大國礼, 神山望, 中路翔太, 木原章雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府東大阪市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26251010

1. OBARA Keisuke (30419858)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. IGARASHI Yasuyuki (70091965)

# of Collaborated Projects: 3 results

# of Collaborated Products: 36 results
3. MITSUTAKE Susumu (10344475)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. SASSA Takayuki (20342793)

# of Collaborated Projects: 3 results

# of Collaborated Products: 41 results
5. YATOMI Yutaka (60200523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHNO Yusuke (50611498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 49 results
7. 和田淳 (00301953)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIZUTANI Yukiko (30396296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. IWAKI Soichiro (60399962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. 岡島史和 (30142748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 井ノ口仁一 (70131810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HATTORI Satoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. AKIYAMA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. SUGIURA Kazumitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 平林哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 奈良篤樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 鈴木邦律

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 永沼達郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 黒滝大翼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 武市拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kihara Akio 木原 章雄

KIHARA Akio 木原 章雄

Research Projects

Research Products

Co-Researchers

Formation of biological barriers by diverse ceramidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of biological functions by very long-chain lipids and molecular mechanism of the related pathologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Metabolic pathways creating and maintaining ceramide diversity, and molecular mechanism of the pathology due to their impairmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スフィンゴシン1-リン酸代謝経路に関わる遺伝子の同定と関連疾患の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

パルミトイル化によるタンパク質機能調節と病態の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism sensing lipid asymmetry and transducing the signalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スフィンゴシン１－リン酸代謝経路の解明とシェーグレン・ラルソン症候群の原因究明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the sensor molecule that senses lipid asymmetry and elucidation of the molecular mechanism of its intracellular signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

三量体Gタンパク質共役型受容体の脂質修飾による新たな制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological functions of Sphingolipids and their relevance to pathological phenomena

Principal Investigator

Project Period (FY)

Research Category

Kihara Akio 木原章雄

KIHARA Akio 木原章雄

[Book] セラミド研究の新展開　～基礎から応用へ～2019

[Book] セラミド研究の新展開　～基礎から応用へ～2019