HASUWA HIDETOSHI 蓮輪英毅

… Alternative Names

蓮輪英毅ハスワヒデトシ

HASUWA Hidetoshi 蓮輪英毅

運輪英毅ハスワヒデトシ

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Researcher Number	50343249
Other IDs
External Links
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 医学部(信濃町), 講師 2020 – 2023: 慶應義塾大学, 医学部(信濃町), 講師 2013 – 2014: 慶應義塾大学, 医学部, 講師 2007 – 2012: Osaka University, 微生物病研究所, 助教 2005 – 2006: 大阪大学, 微生物病研究所, 助手 2002 – 2004: 大阪大学, 遺伝情報実験センター, 助手
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Endocrinology / Biological Sciences / Biological Sciences / Laboratory animal science Except Principal Investigator Biological Sciences / Biological Sciences / Laboratory animal science
Keywords	Principal Investigator 遺伝子改変動物 / ゴールデンハムスター / マイクロRNA / ノックアウトマウス / miRNA / ゲノム編集 / non-coding RNA / RNAi / ヒトモデル動物 / piRNA … More / PIWI / 小分子RNA / 遺伝子発現制御 / トランスポゾン / エピジェネティクス / 機能性RNA / PIWI遺伝子 / 生殖細胞 / ovulation / pituitary / RNA / 非コードRNA / 生殖内分泌 / 生殖 / 翻訳制御 / レンチウイルス / がん / RNAポリメラーゼIIIプロモーター / polIII / EGFP / トランスジェニックマウス / siRNA … More Except Principal Investigator loxPシステム / cre / 遺伝子破壊 / 遺伝子改変動物 / レンチウイルスベクター / 多能性 / 全能性 / 胚発生 / クラスター遺伝子 / トランスポゾン / MAPC cells / chimera / implantation / red mouse / green rat / green mouse / 妊娠 / マウス / ラット / 異種移植 / GFP / 幹細胞 / 骨髄細胞 / loxP / トランスジェニックマウス / Creリコンビナーゼ / ジフテリアトキシン / 異種胚キメラ / MAPC細胞 / キメラ / 着床 / レッドマウス / グリーンラット / グリーンマウス / 排卵 / 性転換マウス / ゲノム・インプリント / 異種キメラ / 受精 / 分子シャペロン / 不妊 / 遺伝子組換え動物 / 生殖細胞 / ノックアウトマウス / エピジェネティック / マイクロRNA / ジーントラップ Less

Understanding of embryonic development by fathoming multi-copy genetic elements
- Principal Investigator
  
  塩見春彦
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
遺伝子改変ゴールデンハムスターを用いた初期胚発生に保存された生命現象の解明Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Keio University
トランスジェニックゴールデンハムスターの作製と精子凍結保存法の開発Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Keio University
PIWI-piRNA pathway analysis in female germ cellPrincipal Investigator
- Principal Investigator
  
  HASUWA HIDETOSHI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Keio University
高次生命現象を指標としたｍｉＲＮＡ－標的遺伝子作用マシナリーの解明Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  Osaka University
Analysis of pituitary function regulated by miRNAPrincipal Investigator
- Principal Investigator
  
  HIDETOSHI Hasuwa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Keio University
  Osaka University
Mechanism of mammalian fertilization and epigenomic regulation of germline cells.
- Principal Investigator
  
  OKABE Masaru
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of miRNA functions from miRNA knockout mousePrincipal Investigator
- Principal Investigator
  
  HASUWA Hidetoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
ノックアウトマウスを用いた生体内におけるマイクロRNAの機能解析Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
RNAiを用いた新しいがん治療法の開発Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
レンチウイルスベクターを用いた網羅的ノックアウトマウスライブラリーの構築
- Principal Investigator
  
  伊川正人
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
レンチウイルスベクターを用いた網羅的ノックアウトマウスライブラリーの構築
- Principal Investigator
  
  伊川正人
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
哺乳類におけるRNAiの確立とRNAiを用いた受精機能の解析Principal Investigator
- Principal Investigator
  
  蓮輪英毅
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University
Study of implantation using molecular biological means using xeno-chimeric embryos.
- Principal Investigator
  
  OKABE Masaru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Osaka University

All 2023 2021 2014 2013 2011 2010 2008 2007 2005 2004 2002 Other

All Journal Article Presentation Book

[Book] RNA工学の最前線2005
- Author(s)
  蓮輪英毅
- Total Pages
  10
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-17016047
[Journal Article] Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation2021
- Author(s)
  Ishino Kyoko、Hasuwa Hidetoshi、Yoshimura Jun、Iwasaki Yuka W、Nishihara Hidenori、Seki Naomi M、Hirano Takamasa、Tsuchiya Marie、Ishizaki Hinako、Masuda Harumi、Kuramoto Tae、Saito Kuniaki、Sakakibara Yasubumi、Toyoda Atsushi、Itoh Takehiko、Siomi Mikiko C、Morishita Shinichi、Siomi Haruhiko
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 5 Pages: 2700-2720
- DOI
  10.1093/nar/gkab059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05466, KAKENHI-PUBLICLY-19H05268, KAKENHI-PLANNED-19H05753, KAKENHI-PROJECT-18H02421, KAKENHI-PROJECT-18J22025, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-17K19424, KAKENHI-PROJECT-20H03175, KAKENHI-PROJECT-16H06276
[Journal Article] Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters2021
- Author(s)
  Hasuwa Hidetoshi、Iwasaki Yuka W.、Au Yeung Wan Kin、Ishino Kyoko、Masuda Harumi、Sasaki Hiroyuki、Siomi Haruhiko
- Journal Title
  
  Nature Cell Biology
  
  Volume: 23 Issue: 9 Pages: 1002-1012
- DOI
  10.1038/s41556-021-00745-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05753, KAKENHI-PUBLICLY-21H00259, KAKENHI-PROJECT-20H03175, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18H05214
[Journal Article] miR-200b and miR-429 function in mouse ovulation and are essential for female fertility2013
- Author(s)
  Hasuwa H, Ueda J, Ikawa M, Okabe M
- Journal Title
  
  Science
  
  Volume: 341 Pages: 71-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591363
[Journal Article] miR-200b and miR-429 function in mouse ovulation and are essential for female fertility2013
- Author(s)
  Hidetoshi Hasuwa, Jun Ueda, Masahito Ikawa, Masaru Okabe
- Journal Title
  
  Science
  
  Volume: 341 Pages: 71-73
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24115710
[Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model2011
- Author(s)
  Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Issue: 4 Pages: 1451-5
- DOI
  10.1073/pnas.1011293108
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008, KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22791528
[Journal Article] From the Cover : Pravastatin induces placental growth factor(PGF)and ameliorates preeclampsia in a mouse model.2011
- Author(s)
  Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M.
- Journal Title
  
  Proc Natl Acad Sci USA 108
  
  Pages: 1451-1455
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008
[Journal Article] Transgenic Mouse Sperm that Have Green Acrosome and Red Mitochondria Allow Visualization of Sperm and Their Acrosome Reaction in Vivo.2010
- Author(s)
  Hasuwa H, et.al.
- Journal Title
  
  Experimental Animals 59
  
  Pages: 105-107
- NAID
  10027852768
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008
[Journal Article] Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain.2004
- Author(s)
  Matsumura H, Hasuwa H, Inoue N, Ikawa M, Okabe M.
- Journal Title
  
  Biochem Biophys Res Commun 321
  
  Pages: 75-79
- Data Source
  KAKENHI-PROJECT-16011236
[Journal Article] Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain2004
- Author(s)
  H.Matsumura, H.Hasuwa, N.Inoue, M.Ikawa, M.Okabe
- Journal Title
  
  Biochem Biophys Res Commun 321(2)
  
  Pages: 275-279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380383
[Journal Article] Small interfering RNA and gene silencing in transgenic mice and rats2002
- Author(s)
  H.Hasuwa, K.Kaseda, T.Einarsdottir, M.Okabe
- Journal Title
  
  FEBS Lett 532(1-2)
  
  Pages: 227-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380383
[Journal Article] Small interfering RNA and gene silencing in transgenic mice and rats2002
- Author(s)
  H.Hasuwa et al.
- Journal Title
  
  FEBS Lett 532(1-2)
  
  Pages: 227-230
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14380383
[Journal Article] Micro RNAs miR-200b and miR-429 are Essential for Female Fertility in the Mouse by Ensuring Ovulation
- Author(s)
  Hasuwa H, Ueda J, Ikawa M, Okabe M
- Journal Title
  
  Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062008
[Presentation] ゴールデンハムスターを用いることで明らかとなった母性PIWI-piRNA 経路の必要性2023
- Author(s)
  蓮輪英毅
- Organizer
  第3回有性生殖研究会「生殖の多様性」
- Invited
- Data Source
  KAKENHI-PROJECT-20H03175
[Presentation] Disruption of miR-200b and miR-429 leads to anovulation in female mouse2014
- Author(s)
  Hidetoshi Hasuwa, Jun Ueda, Masahito Ikawa, Masaru Okabe
- Organizer
  KEYSTONE SYMPOSIA
- Place of Presentation
  Seattle, Washington, USA
- Data Source
  KAKENHI-PROJECT-24591363
[Presentation] Disruption of miR-200b and miR-429 leads to an ovulation in female mouse2014
- Author(s)
  Hidetoshi Hasuwa, Jun Ueda, Masahito Ikawa, Masaru Okabe
- Organizer
  KEYSTONE SYMPOSIA
- Place of Presentation
  Seattle, Washington, USA
- Data Source
  KAKENHI-PUBLICLY-24115710
[Presentation] マイクロRNAにより制御される排卵システム2014
- Author(s)
  蓮輪　英毅
- Organizer
  第32回日本受精着床学会総会学術講演会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-24591363
[Presentation] miR-200b欠損マウスの解析2008
- Author(s)
  蓮輪英毅
- Organizer
  日本実験動物科学技術2008
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20700364
[Presentation] Disruption of miR-200b Leads to Female Infertility2008
- Author(s)
  蓮輪英毅
- Organizer
  41st Annual SSR Meeting
- Place of Presentation
  Kailua-Kona, Hawaii
- Data Source
  KAKENHI-PROJECT-20700364
[Presentation] miR-200b欠損マウスの解析2008
- Author(s)
  蓮輪英毅
- Organizer
  日本実験動物科学技術2008
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-20700364
[Presentation] 遺伝子ノックアウト法により見えてきたmiRNAが寄与する生命現象2007
- Author(s)
  蓮輪英毅
- Organizer
  第30回日本分子生物学会年会 (シンポジウム)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18700397
[Presentation] マイクロRNAを必須の要素としていた排卵システム
- Author(s)
  蓮輪　英毅
- Organizer
  第55回日本卵子学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-05-17 – 2014-05-18
- Invited
- Data Source
  KAKENHI-PROJECT-24591363

1. 伊川正人 (20304066)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. OKABE Masaru (30089875)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. ISOTANI Ayako (20444523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 塩見春彦 (60202107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小嶋将平 (30851703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 坂下陽彦 (60893873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 塩見美喜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASUWA HIDETOSHI 蓮輪 英毅

蓮輪 英毅 ハスワ ヒデトシ

HASUWA Hidetoshi 蓮輪 英毅

運輪 英毅 ハスワ ヒデトシ

Research Projects

Research Products

Co-Researchers

Understanding of embryonic development by fathoming multi-copy genetic elements

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子改変ゴールデンハムスターを用いた初期胚発生に保存された生命現象の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

トランスジェニックゴールデンハムスターの作製と精子凍結保存法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PIWI-piRNA pathway analysis in female germ cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高次生命現象を指標としたｍｉＲＮＡ－標的遺伝子作用マシナリーの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of pituitary function regulated by miRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of mammalian fertilization and epigenomic regulation of germline cells.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of miRNA functions from miRNA knockout mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ノックアウトマウスを用いた生体内におけるマイクロRNAの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAiを用いた新しいがん治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

レンチウイルスベクターを用いた網羅的ノックアウトマウスライブラリーの構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

レンチウイルスベクターを用いた網羅的ノックアウトマウスライブラリーの構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

哺乳類におけるRNAiの確立とRNAiを用いた受精機能の解析Principal Investigator

HASUWA HIDETOSHI 蓮輪英毅

蓮輪英毅ハスワヒデトシ

HASUWA Hidetoshi 蓮輪英毅

運輪英毅ハスワヒデトシ