Hara Kazuo 原一雄

… Alternative Names

HARA Kazuo 原一雄

Less

Researcher Number	50359600
External Links
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授 2025: 東京医科大学, 医学部, 兼任教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 東京医科大学, 医学部, 兼任教授 2014: 東京大学, 医学部附属病院糖尿病・代謝内科 2011 – 2012: 東京大学, 医学部附属病院, 特任准教授 2010: 東京大学, 医学部附属病院, 准教授 2007 – 2009: 東京大学, 医学部附属病院, 講師 … More 2007 – 2008: The University of Tokyo, Faculty of Medicine, Lecturer 2005 – 2006: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 2005: 東京大学, 医学部付属病院, 助手 2004 – 2005: 東京大学, 医学部附属病院, 科学技術振興特任教員 2004: 東京大学, 医学部・附属病院, 科学技術振興特任教員 2004: 東京大学, 医学部附属病院, 研究拠点形成特任教員 2004: University of Tokyo Hospital, Department of Metabolic Diseases, Assistant, 医学部附属病院糖尿病・代謝内科, 助手 2003: 東京大学, 医学部・附属病院, 特任教員(常勤形態) 2003: 東京大学, 医学部付属病院, 特任教員(常勤形態) 2003: the University of Tokyo, faculty of Medicine, Visiting Medical Staff, 医学部附属病院, 科学技術振興特任教員(常勤形態) Less
Review Section/Research Field	Principal Investigator Metabolomics / Pathological medical chemistry / Applied genomics Except Principal Investigator Metabolomics / Biological Sciences / Metabolomics / Medical genome science
Keywords	Principal Investigator インスリン抵抗性 / 2型糖尿病 / SNP / 遺伝子多型 / メタボリックシンドローム / 脂肪細胞 / 遺伝子 / ゲノム / 遺伝素因 / 疾患感受性遺伝子 … More / 感受性遺伝子 / ゲノム解析 / adiponectin / affected sib pair / diabetes / Haplotype / 連鎖不平衡 / 相関解析 / 遺伝子発現 / バイオテクノロジー … More Except Principal Investigator 糖尿病 / diabetes / アディポネクチン / アディポカイン / adipokine / インスリン抵抗性 / 動脈硬化 / Stra13 / IRS-2 / IRS-1 / receptor / 受容体 / PPAR / AMP kinase / obesity / AMPキナーゼ / 肥満 / adiponectin / アディポネクチン受容体 / SNP / 一塩基多型 / ゲノム / promoter / プロモーター / exocytosis / glucokinase / high-fat diet / pancreatic beta-cells / 開口放出 / グルコキナーゼ / 高脂肪食 / 膵β細胞 / gene targeting / insulin resistance / Diabetes / 遺伝子欠損マウス / nuclear receptors / glucose uptake / fatty acid oxidation / adiponectin resistance / adiponectin receptors / レプチン / PPARγ / 脂質代謝異常 / 核内受容体型転写因子 / 糖取り込み / 脂肪酸燃焼 / アディポネクチン抵抗性 / affected sib pair / Haplotype / 全ゲノムスキャン / 罹患同胞対法 / 個人情報匿名化 / 脂肪細胞 / 2型糖尿病 / 連鎖不平衡 / 相関解析 / 罹患同胞対 / ハプロタイプ / 疾患関連遺伝子 / 脂質代謝 / 糖代謝 / AdipoR / インスリン / アゴニスト / 生命システム / 虚血性心疾患 / 転写制御 / ゲノム解析 / 臨床情報 / 生活習慣病 / データベース Less

Function of type 2 diabetes susceptibility genes SLC16A11/13Principal Investigator
- Principal Investigator
  
  Hara Kazuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical University
Assessing the clinical utility of the genetic information using the genotype data for GWAS-derived type 2 diabetes susceptibility variants in a Japanese population.
- Principal Investigator
  
  IWATA MINORU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  University of Toyama
Clarification of genetic architecture of type 2 diabetes using expression analysisPrincipal Investigator
- Principal Investigator
  
  HARA Kazuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Integrated elucidation of metabolic pathway in the physiology and pathology
- Principal Investigator
  
  KADOWAKI Takashi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Clarification of developing metabolic syndrome by using expressionanalysis of human visceral adipose tissuePrincipal Investigator
- Principal Investigator
  
  HARA Kazuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
アディポネクチン受容体アゴニストの植物からの探索と糖尿病の根本的治療薬・食品開発
- Principal Investigator
  
  YAMAUCHI Toshimasa
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Physiological and pathophysiological roles ofAdiponectin receptors and identification of molecular targets for treatment of life-style related diseases
- Principal Investigator
  
  KADOWAKI Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Identification of transcription factor which regulates obesity-linked downregulation of adiponectin gene and development of treatment modality for metabolic syndrome
- Principal Investigator
  
  YAMAUCHI Toshimasa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
The systematic analysis on the diseases through the integration of the clinical data with the genomic information
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Physiological and pathophysiological roles and signal transduction of adiponectin receptors
- Principal Investigator
  
  KADOWAKI Takashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Differentiation, proliferation, and function of pancreatic beta-cells
- Principal Investigator
  
  YAMAUCHI toshimasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Identification of type 2 diabetes susceptibility genes in the Japanese population by linkage disequilibrium mapping in the chromosomal regions harboring type 2 diabetes susceptibility genesPrincipal Investigator
- Principal Investigator
  
  HARA Kazuo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied genomics
- Research Institution
  The University of Tokyo
The pathophysiological roles of adiponectin in the regulation of type 2 diabetes, hyperlipidemia and atherosclerosis
- Principal Investigator
  
  KADOWAKI Takashi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  the University of Tokyo
Identification of type 2 diabetes susceptibility genes in the Japanese population by genome mapping and candidate gene approach and functional analysis
- Principal Investigator
  
  KADOWAKI Takashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo

[Book] 【メタボリックシンドロームup to date】検査・診断アディポネクチン2007
- Author(s)
  山内敏正、原一雄、門脇孝
- Publisher
  日本医師会雑誌
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] 日本人における2型糖尿病感受性遺伝子の同定2016
- Author(s)
  原一雄
- Journal Title
  
  BIO Clinica
  
  Volume: 12 Pages: 1316-1321
- Data Source
  KAKENHI-PROJECT-16K08631
[Journal Article] 2型糖尿病リスク遺伝子SLC16A13の機能に関する検討2016
- Author(s)
  原一雄, 熊谷勝義, 小田原雅人
- Journal Title
  
  日本成人病(生活習慣病)学会会誌
  
  Volume: 42 Pages: 65-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08631
[Journal Article] Genome-wide association study identifies three novel loci for type 2 diabetes2014
- Author(s)
  Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, et al
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23 Issue: 1 Pages: 239-246
- DOI
  10.1093/hmg/ddt399
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591361, KAKENHI-PROJECT-24510276, KAKENHI-PROJECT-25221307
[Journal Article] Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX42013
- Author(s)
  Ma R. C. W., Hu C., Tam C. H.,..., Hara K.,..., Yamauchi T.,..., Kadowaki T., Tai E. S., Zeggini E., McCarthy M. I., Hon K. L., Baum L., Tomlinson B., So W. Y., Bao Y., Chan J. C. N., Jia W
- Journal Title
  
  Diabetologia
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Genome-wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India2013
- Author(s)
  Saxena R, Yamauchi T, Hara K Saxena R, Yamauchi T, Hara K DIAGRAM MuTHER; TGEN, Kadowaki T
- Journal Title
  
  Diabetes
  
  Volume: 62 Issue: 5 Pages: 1746-1755
- DOI
  10.2337/db12-1077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-23591327, KAKENHI-PROJECT-24510276, KAKENHI-PROJECT-25253068
[Journal Article] Expression-based genome-wide association study links CD44 in adipose tissue with type 2 diabetes2012
- Author(s)
  Kodama K,…Hara K, et al.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: (採択)(未定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals2012
- Author(s)
  Iwata M, Hara K, Kadowaki T
- Journal Title
  
  Diabetes Care
  
  Volume: 35 Issue: 8 Pages: 1763-1770
- DOI
  10.2337/dc11-2006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22591021, KAKENHI-PROJECT-24510276
[Journal Article] Expression-based genome-gide association study links CD44 in adipose tissue with type 2 diabetes2012
- Author(s)
  Kodama K, Hara K, Kadowaki T, Butte AJ
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Issue: 18 Pages: 7049-7054
- DOI
  10.1073/pnas.1114513109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T: A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012
- Author(s)
  Imamura M,1,Yamauchi T, Hara K, Okada-Iwabu M, Iwabu M
- Journal Title
  
  Human Molecular Genatics
  
  Volume: 21 Pages: 3042-3049
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice2012
- Author(s)
  Shojima N, Hara K, Kubota N, Yamauchi T, Ueki K, Kadowaki T
- Journal Title
  
  Diabetologia
  
  Volume: 55 Issue: 12 Pages: 3318-3330
- DOI
  10.1007/s00125-012-2711-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Erectile dysfunction and cardiovascular events in diabetic menmeta-analysis of observational studies2012
- Author(s)
  Yamada T, Hara K, Umematsu H, Suzuki R, Kadowaki T.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 9 Pages: e43673-e43673
- DOI
  10.1371/journal.pone.0043673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-23689047
[Journal Article] Diabetes Genetics Replication and Meta-analysis(DIAGRAM) Consortium, Nakamura Y, Kadowaki T. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations2012
- Author(s)
  Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Iwata M, Hirose H, KakuK, Ito C, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Kasuga M, Kamatani N
- Journal Title
  
  Hum Mol Genet
  
  Pages: 22456796-22456796
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes2012
- Author(s)
  Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109(18) Pages: 7049-54
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.2012
- Author(s)
  Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K,..., Okada-Iwabu M, Iwabu M, Shojima N,..., Nakamura Y, Kadowaki T
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 21 Issue: 13 Pages: 3042-3049
- DOI
  10.1093/hmg/dds113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22591021, KAKENHI-PROJECT-23591361, KAKENHI-PROJECT-24510276, KAKENHI-PROJECT-23689048, KAKENHI-PROJECT-24790908
[Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies.2012
- Author(s)
  Yamada T, Hara K, Kadowaki T
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 7 Pages: e42031-e42031
- DOI
  10.1371/journal.pone.0042031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits2012
- Author(s)
  Fujita H, Hara K, Kadowaki T
- Journal Title
  
  J Hum Genet
  
  Volume: 57 Issue: 12 Pages: 776-779
- DOI
  10.1038/jhg.2012.110
- NAID
  10031145885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22790862, KAKENHI-PROJECT-24229007, KAKENHI-PROJECT-24510276
[Journal Article] Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARγ-Dependent Nongenomic Signaling2011
- Author(s)
  Endo Y, Suzuki M, Yamada H, Horita s, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
- Journal Title
  
  Cell Metabolism
  
  Volume: 13 Pages: 550-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage妖erived IL-6 dependent pathway2011
- Author(s)
  Awazawa M, Ueki K, Yamauchi T, Kubota, Kadowaki T
- Journal Title
  
  Cell Metabolism
  
  Volume: 13 Issue: 4 Pages: 401-412
- DOI
  10.1016/j.cmet.2011.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-21390278, KAKENHI-PROJECT-23791019
[Journal Article] Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells2011
- Author(s)
  Kitajima, K,Miura S, Yamauchi T, Uehara Y, Kiya Y, Rye KA, Kadowaki T, Saku K
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 411 Issue: 2 Pages: 305-311
- DOI
  10.1016/j.bbrc.2011.06.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.2011
- Author(s)
  Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itch S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki 0, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, TsutsuiM, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
- Journal Title
  
  Cell Metab.
  
  Volume: 13 Pages: 294-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency2011
- Author(s)
  Saheki T, Inoue K, Ono H, Tushima A, Katsura N, Yokogawa M, Yoshidumi Y, Kuhara T, Ohse M, Eto K, Kadowaki T, Sinasac DS, Kobayashi K
- Journal Title
  
  Mol Genet Metab
  
  Volume: 104 Issue: 4 Pages: 492-500
- DOI
  10.1016/j.ymgme.2011.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians2011
- Author(s)
  Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, KimHL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, NgDP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman AK, Morris AP, McCarthy MI ; DIAGRAM Consortium ; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M
- Journal Title
  
  Nat Genet
  
  Volume: 44(1) Pages: 67-72
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] Meta-analysis of genome-wide asso- ciation studies identifies eight new loci for type 2 diabetes in east Asians2011
- Author(s)
  Cho YS, Yamauchi T, Hara K, Kadowaki T
- Journal Title
  
  Nature Genatics
  
  Volume: 44 Issue: 1 Pages: 67-72
- DOI
  10.1038/ng.1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-21390209, KAKENHI-PROJECT-21591124, KAKENHI-PROJECT-23390247, KAKENHI-PROJECT-23591327, KAKENHI-PROJECT-24591347
[Journal Article] Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle.2011
- Author(s)
  Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
- Journal Title
  
  Cell Metabolism 13
  
  Pages: 294-307
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Blockade of class lB phosphor inositide-3 kinase ameliorates obesity induced inflammation and insulin resistance2011
- Author(s)
  Kobayashi N, Ueki, Kubota N, Hara K, Kadowaki T
- Journal Title
  
  Proc. Nat/. Acad. Sci. U.S.A.
  
  Volume: 108 Pages: 5753-5758
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via macrophage-derived IL-6 dependent pathway.2011
- Author(s)
  Awazawa M, Ueki K, Inabe K, Yamauchi T, Kubota N, Kaneko K, Kobayashi M, Iwane A, Sasako T, Ohsugi M, Takamoto I, Yamashita S, Asahara H, Akira S, Kasuga M, Kadowaki T
- Journal Title
  
  Cell Metabolism 13
  
  Pages: 401-412
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance2011
- Author(s)
  Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, Awazawa M, Kobayashi M, Sasako T, Kaneko K, Suzuki M, Nishikawa Y, Hara K, Yoshimura K, Koshima I, Goyama s, Murakami K, Sasaki J, Nagai R, Kurokawa M, Sasaki T, Kadowaki T
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Issue: 14 Pages: 5753-5758
- DOI
  10.1073/pnas.1016430108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21390278, KAKENHI-PROJECT-21591124
[Journal Article] Evaluating Japanese patients with the Marfan syndrome using high-through put microarray-based mutational analysis of fibrillin-1 gene2011
- Author(s)
  Ogawa N, Imai Y, Takahashi Y, Nawata K, Hara K, et al.
- Journal Title
  
  Am J Cardiol
  
  Volume: 108 Issue: 12 Pages: 1801-7
- DOI
  10.1016/j.amjcard.2011.07.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591124, KAKENHI-PROJECT-22590923
[Journal Article] Evaluating Japanese patients with the Marfan syndrome using high-throughput microarray-based mutational analysis of fibrillin-1 gene2011
- Author(s)
  Ogawa N, Imai Y, Takahashi Y, Nawata K, Hara K, Nishimura H, Kato M, Takeda N, Kohro T, Morita H, Taketani T, Morota T, Yamazaki T, Goto J, Tsuji S, Takamoto S, Nagai R, Hirata Y
- Journal Title
  
  Am J Cardiol
  
  Volume: 108(12) Pages: 1801-7
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals2011
- Author(s)
  Grarup N, Yamauchi T, Hara K, Kadowaki T
- Journal Title
  
  Diabetologia
  
  Volume: 54 Issue: 4 Pages: 789-794
- DOI
  10.1007/s00125-010-2031-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Adiponectin and AdipoRl regulate PGCI and mitochondria by Ca^<2+> and AMPK/SIRTI.2010
- Author(s)
  Iwabu M, Yamauchi T, Okada-lwabu M, Sato K, Nakagawa T, Funata M, Pamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, .Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
- Journal Title
  
  Nature
  
  Volume: 464 Pages: 1313-1319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associaed with human hypertension.2010
- Author(s)
  Oishi Y, Manabe I, Imai Y, Hara K, Horikoshi M, Fujiu K, Tanaka T, Aizawa T, Kadowaki T, Nagai R
- Journal Title
  
  FASEB J (published online Jan.26, 2010)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.2010
- Author(s)
  Yamauchi T, Hara K, Maeda S, et al
- Journal Title
  
  Nat. Genet.
  
  Volume: 42 Pages: 864-868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] Adiponectin and AdipoR1 regulate PGC1・and mitochondria by Ca^<2+> and AMPK/SIRT1.2010
- Author(s)
  Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
- Journal Title
  
  Nature 464
  
  Pages: 1313-1319
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms.2010
- Author(s)
  Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
- Journal Title
  
  Cell Metabolism 12
  
  Pages: 619-632
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin 11 and is associated with human hypertension2010
- Author(s)
  Oishi Y, Hara K, Kadowaki T
- Journal Title
  
  FASBB J
  
  Volume: 24 Issue: 6 Pages: 1780-1788
- DOI
  10.1096/fj.09-146589
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBEZE2 and C2CD4A-C2CD4B.2010
- Author(s)
  Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujito H, Grarup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-lwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jorgensen T, Lauritzen T, Sandbak A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwag A, Kawamori R, Kasuga M, Frogue P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T
- Journal Title
  
  Nature Genetics
  
  Volume: 42 Pages: 864-868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms.2010
- Author(s)
  Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkami RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
- Journal Title
  
  Cell Metab.
  
  Volume: 12 Pages: 619-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Adiponectin and AdipoR1 regulate PGC-lalpha and mitochondria by Ca(2+) and AMPK/SIRT1.2010
- Author(s)
  Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T.
- Journal Title
  
  Nature (published online Mar.31, 2010)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009
- Author(s)
  Nishimura S, Hara K, Ueki K, Kadowaki T
- Journal Title
  
  Nature Medicine
  
  Volume: 15 Issue: 8 Pages: 914-920
- DOI
  10.1038/nm.1964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-21390278, KAKENHI-PROJECT-21390321
[Journal Article] Successful desensitization by glargine administration in patient with insulin allergy : a case report.2009
- Author(s)
  Hara M, Izumida Y, Sato N, Ohashi K, Osuga JI, Tobe K, Tsukamoto K, Kadowaki T
- Journal Title
  
  Diabetes Res Clin Pract 84
  
  Pages: 48-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association.2009
- Author(s)
  Miyake K, Yang W, Hara K, et al.
- Journal Title
  
  J Hum Genet 54
  
  Pages: 236-41
- NAID
  10030730081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591124
[Journal Article] Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6, 244 Japanese individuals2009
- Author(s)
  Omori S, Tanaka Y, Horikoshi M, Takahashi A, Hara K, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Kadowaki T, Nakamura Y, Maeda S.
- Journal Title
  
  Diabetologia 52(8)
  
  Pages: 1554-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
- Journal Title
  
  Nat Med 15(8)
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
- Journal Title
  
  Nat Med 15
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association2009
- Author(s)
  Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MC, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Wang HY, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RC, So WY, Chan JC, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M.
- Journal Title
  
  J Hum Genet 54(4)
  
  Pages: 236-41
- NAID
  10030730081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] How controlling of hypertension might matter-Beyond blood pressure-2009
- Author(s)
  Hara K, Kadowaki T
- Journal Title
  
  Circulation J 73
  
  Pages: 2208-2209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008
- Author(s)
  Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.
- Journal Title
  
  Nat Genet 40(9)
  
  Pages: 1092-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population2008
- Author(s)
  Wang G, Watanabe M, Imai Y, Hara K, Manabe I, Maemura K, Horikoshi M, Kohro T, Amiya E, Sugiyama T, Fujita T, Kadowaki T, Yamazaki T, Nagai R.
- Journal Title
  
  Int Heart J. 49(3)
  
  Pages: 313-327
- NAID
  130000069020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008
- Author(s)
  Okamoto M, Ohara-Imaizumi M, Kubota N, Hashimoto S, Eto K, Kanno T, Kubota T, Wakui M, Nagai R, Noda M, Nagamatsu S, Kadowaki T.
- Journal Title
  
  Diabetologia 51(5)
  
  Pages: 827-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Yasuda Ket al.Association of TCF7L2polymorphisms with susceptibility to type 2diabetes in 4,087 Japanesesubjects2008
- Author(s)
  Miyake K, Horikawa Y, Hara K
- Journal Title
  
  J Hum Genet. 53(2)
  
  Pages: 174-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] SNPs in KCNQI are associated with susceptibility to type 2 diabetes in East Asian and European populations.2008
- Author(s)
  Unoki H, Takahashi A, Kawaguchi T, Hara K. et al.
- Journal Title
  
  Nature Genetics 40
  
  Pages: 1098-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Variants in KCNQ1 areassociated with susceptibility to type2 diabetes mellitus2008
- Author(s)
  Yasuda K, Miyake K, Horikawa Y,Hara K et.al.
- Journal Title
  
  Nature Genetics 40(9)
  
  Pages: 1092-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008
- Author(s)
  Yasuda K, Hara K, Kadowaki T
- Journal Title
  
  Nature Genetics
  
  Volume: 40 Issue: 9 Pages: 1092-1097
- DOI
  10.1038/ng.207
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008
- Author(s)
  Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S.
- Journal Title
  
  Nat Genet 40(9)
  
  Pages: 1098-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Genetic variations ofMrf-2/ARID5B confer risk of coronaryatherosclerosis in theJapanese population2008
- Author(s)
  Wang G, Watanabe M, Imai Y,Hara K et.al.
- Journal Title
  
  Int Heart J 49(3)
  
  Pages: 313-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008
- Author(s)
  Unoki H, Hara K, Kadowaki T
- Journal Title
  
  Nature Genetics
  
  Volume: 40 Issue: 9 Pages: 1098-1102
- DOI
  10.1038/ng.208
- Data Source
  KAKENHI-PROJECT-20229008
[Journal Article] SNPs in KCNQ1are associated with susceptibility totype 2 diabetes in East Asian andEuropean populations2008
- Author(s)
  Unoki H, Takahashi A,KawaguchiT, Hara K et.al.
- Journal Title
  
  Nature Genetics 40(9)
  
  Pages: 1098-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japnese population based on 11 genes with strong evidence of the association.2008
- Author(s)
  Miyake K, Yang W, Hara K et al.
- Journal Title
  
  J Hum Genet 54
  
  Pages: 236-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Variants in KCNQI are associated with susceptibility to type 2 diabetes mellitus.2008
- Author(s)
  Yasuda K, Miyake K, Horikawa Y, Hara K et al.
- Journal Title
  
  Nature Genetics 40
  
  Pages: 1092-1097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid.2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clin Chem. 53
  
  Pages: 1541-1544
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Improved EHSA for selective measmement of adiponectin multimers and identification of adipollectin in human cerebrospinal fluid2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clin Chem 53
  
  Pages: 1541-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Targeted disruption of AdipoRl and AdipoR2 causes abrogation of adiponectin binding and metabohc actions2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tbkuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
- Journal Title
  
  Nat Med 13
  
  Pages: 332-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid.2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clin Chem. 53
  
  Pages: 1541-1544
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clin Chem. 53
  
  Pages: 1541-1544
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara
- Journal Title
  
  Nat Med. 13
  
  Pages: 332-339
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population2007
- Author(s)
  Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.
- Journal Title
  
  Diabetologia. 50(4)
  
  Pages: 747-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K,Tobe K,Nagai R,Ueki K,Kadowaki T.
- Journal Title
  
  Nat Med. 13
  
  Pages: 332-339
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y,Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
- Journal Title
  
  Nat Med. 13(3)
  
  Pages: 332-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Frequency of the G/G genotypeof resistin single nucleotide polymorphism at-420 appears to beincreased in younger-onset type 2diabetes2007
- Author(s)
  Ochi M, Osawa H, Hirota Y, HaraK et.al.
- Journal Title
  
  Diabetes 56(11)
  
  Pages: 2834-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Ito C,Shojima N et al.Variations in theHHEXgene are associated with increased risk of type 2 diabetes in the Japanesepopulation2007
- Author(s)
  Horikoshi M, Hara K
- Journal Title
  
  Diabetologia 50(12)
  
  Pages: 2461-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population2007
- Author(s)
  Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T.
- Journal Title
  
  Diabetologia 50(12)
  
  Pages: 2461-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Ito C,Nagai R et al. A genetic variation ofthe transcription factor 7-like 2 geneis associated with risk of type 2 diabetes in the Japanese population2007
- Author(s)
  Horikoshi M, Hara K
- Journal Title
  
  Diabetologia 50(4)
  
  Pages: 747-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591038
[Journal Article] Targeted disruption of AdipoRl and AdipoR2 causes abrogation of adiponectin binding and metabolic actions2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
- Journal Title
  
  Nat Med. 13
  
  Pages: 332-339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Targeted disruption ofAdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions2007
- Author(s)
  Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
- Journal Title
  
  Nat Med. 13
  
  Pages: 322-339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clim Chem 53
  
  Pages: 1541-1544
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Improved EHSA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluid2007
- Author(s)
  Ebinuma H, Miida T, Yamauchi T, Hada Y, Hara K, Kubota N, Kadowaki T.
- Journal Title
  
  Clin Chem 53
  
  Pages: 1541-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Measurement of the high- molecular- weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006
- Author(s)
  Hara T, Yamauchi T, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population2006
- Author(s)
  Horikoshi, M., Hara, K., Ohashi, J., Miyake, K., Tokunaga, K., Ito, C., Kasuga, M., Nagai, R.,, Kadowaki, T.
- Journal Title
  
  Diabetes. 55(4)
  
  Pages: 919-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome2006
- Author(s)
  Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes Care 29(6)
  
  Pages: 1357-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Measurement of the high- molecular- weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006
- Author(s)
  Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population2006
- Author(s)
  Hara, K., Horikoshi, M., Kitazato, H., Ito, C., Noda, M., Ohashi, J., Froguel, P., Tokunaga, K., Tobe, K., Nagai, R., Kadowaki, T.
- Journal Title
  
  Diabetes 55(5)
  
  Pages: 1260-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Measurement of the high-molecular-weight form of adiponectin in plasmais useful for the prediction of insulih resistance and metabolic syndrome.2006
- Author(s)
  Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Measurement of the high- molecular- weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006
- Author(s)
  Hara T, Yamauchi T, Kadowaki T
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Data Source
  KAKENHI-PROJECT-18659265
[Journal Article] Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.2006
- Author(s)
  Hara K
- Journal Title
  
  Diabetes 55・5
  
  Pages: 1260-1264
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Association of Hepatocyte Nuclear Factor-4a P2 Promoter Haplotypes With Type 2 Diabetes in the Japanese Population.2006
- Author(s)
  Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Tokunaga K, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Hepatocyte Nuclear Factor-4α P2 Promoter haplotypes are associated with Type 2 diabetes in the Japanese population.2006
- Author(s)
  Hara K.et al.
- Journal Title
  
  Diabetes (未定)
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Adiponectin and adiponectin receptors in insulin resistance, diabetes,and the metabolic syndrome.2006
- Author(s)
  Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K.
- Journal Title
  
  J.Clin. Invest. 116
  
  Pages: 1784-1792
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Association of Hepatocyte Nuclear Factor-4αP2 Promoter Haplotypes With Type 2 Diabetes in the Japanese Population.2006
- Author(s)
  Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Tokunaga K, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome2006
- Author(s)
  Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K.
- Journal Title
  
  J. Clin. Invest 116
  
  Pages: 1784-1792
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] A polymorphism in the AMPKα2 subunit gene is associated with insulin resistance and type 2 diabetes in Japanese.2006
- Author(s)
  Horikoshi M, Hara K, Ohashi J, Miyake K, Ito C, Kasuga M, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.2006
- Author(s)
  Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K.
- Journal Title
  
  J. Clin. Invest. 116
  
  Pages: 1784-1792
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Measurement of the high-molecular-weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome2006
- Author(s)
  Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Measurement of the high- molecular- weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006
- Author(s)
  Hara T, Yamauchi T, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Data Source
  KAKENHI-PROJECT-18209033
[Journal Article] Hepatocyte Nuclear Factor-4α P2 Promoter haplotypes are associated with Type 2 diabetes in the Japanese population2006
- Author(s)
  Hara K.et al.
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006
- Author(s)
  Hara K
- Journal Title
  
  Diabetes Care 29・6
  
  Pages: 1357-1362
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Measurement of the high- molecular- weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome2006
- Author(s)
  Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes Care 29
  
  Pages: 1357-1362
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] Association of Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes With Type 2 Diabetes in the Japanese Population.2006
- Author(s)
  Hara K
- Journal Title
  
  Diabetes (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome2006
- Author(s)
  Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K.
- Journal Title
  
  J. Clin. Invest. 116
  
  Pages: 1784-1792
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390270
[Journal Article] A polymorphism in the AMPKα2 subunit gene is associated with insulin resistance and type 2 diabetes in Japanese.2006
- Author(s)
  Horikoshi M, Hara K, Ohashi J, Miyake K, Ito C, Kasuga M, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetes (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Expression of DGAT2 in white adipose tissue is regulated by central leptin action.2005
- Author(s)
  Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 3331-3337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.2005
- Author(s)
  Hara K, et al.
- Journal Title
  
  Diabetologia 48
  
  Pages: 1307-1314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209030
[Journal Article] Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population2005
- Author(s)
  Iwasaki N, Horikawa Y, Tsuchiya T, Kitamura Y, Nakamura T, Tanizawa Y, Oka Y, Hara K, Kadowaki T, Awata T, Honda M, Yamashita K, Oda N, Yu L, Yamada N, Ogata M, Kamatani N, Iwamoto Y, Del Bosque-Plata L, Hayes MG, Cox NJ, Bell GI.
- Journal Title
  
  J Hum Genet Feb 5
- NAID
  10014513339
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.2005
- Author(s)
  Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetologia 48
  
  Pages: 1307-1314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Adiponectin : An adipokine linking adipocytes and type 2 diabetes in humans.2005
- Author(s)
  Hara K., et al.
- Journal Title
  
  Current Diabetes Reports (In press)
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Expression of DGAT2 in white adipose tissue is regulated by central leptin action.2005
- Author(s)
  Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 3331-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes2005
- Author(s)
  Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetologia 48(7)
  
  Pages: 1307-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019008
[Journal Article] Absence of an association between SNPs in the gene encoding adiponectin receptors and type 2 diabetes or insulin resistance in the Japanese population2005
- Author(s)
  K.Hara, M.Horikoshi, H.Kitazato, T.Yamauchi, C.Ito, M.Noda, J.Ohnishi, P.Froguel, K.Tokunaga, R.Nagai, T.Kadowaki
- Journal Title
  
  Diabetologia (未定)
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Absence of an association between SNPs in the gene encoding adiponectin receptors and type 2 diabetes or insuln resistance in the Japanese population2005
- Author(s)
  Hara K.et al.
- Journal Title
  
  Diabetologia 48(7)
  
  Pages: 1307-1314
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type2 diabetes.2005
- Author(s)
  Hara K, et al.
- Journal Title
  
  Diabetologia 48(7)
  
  Pages: 1307-1314
- Data Source
  KAKENHI-PROJECT-16209030
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes2005
- Author(s)
  Hara K
- Journal Title
  
  Diabetologia 48
  
  Pages: 1307-1314
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.2005
- Author(s)
  Hara K, et al.
- Journal Title
  
  Diabetologia 48
  
  Pages: 1307-1314
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390263
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.2005
- Author(s)
  Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T.
- Journal Title
  
  Diabetologia 48
  
  Pages: 1307-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Absence of an association between SNPs in the gene encoding adiponectin receptors and type 2 diabetes or insulin resistance in the Japanese population2005
- Author(s)
  Hara K.et al.
- Journal Title
  
  Diabetologia 48(7)
  
  Pages: 1307-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.2005
- Author(s)
  Hara K, et al.
- Journal Title
  
  Diabetologia 48(7)
  
  Pages: 1307-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390263
[Journal Article] Expression of DGAT2 in White Adipose Tissue Is Regulated by Central Leptin Action2005
- Author(s)
  Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T
- Journal Title
  
  J Biol Chem 280・5
  
  Pages: 3331-3337
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Dysadipocytokinemia in werner syndrome and its recovery by treatment with pioglitazone2004
- Author(s)
  Yokote K, Hara K, Mori S, Kadowaki T, Saito Y, Goto M
- Journal Title
  
  Diabetes Care 27・10
  
  Pages: 2562-2563
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity2004
- Author(s)
  Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga
- Journal Title
  
  J Biol Chem 279・29
  
  Pages: 30817-30822
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] SH2-containing inositol phosphatase 2 predominantly regulates akt2, and not akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.2004
- Author(s)
  Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 14835-14843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Insulin/Foxol pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.2004
- Author(s)
  Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 30817-30822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Establishment of a method of anonymization of DNA samples in genetic research.2003
- Author(s)
  Hara K, Ohe K, Kadowaki T, Kato N, Imai Y, Tokunaga K, Nagai R, Omata M.
- Journal Title
  
  J Hum Genet 48
  
  Pages: 327-330
- NAID
  10011595061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Molecular mechanism of insulin resistance and obesity.2003
- Author(s)
  Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R.
- Journal Title
  
  Exp.Biol.Med. 228
  
  Pages: 1111-1117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.2003
- Author(s)
  Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T.
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 40352-40363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Establishment of a method of anonymization of DNA samples in genetic research.2003
- Author(s)
  Hara K, Ohe K, Kadowaki T, Kato N, Imai Y, Tokunaga K, Nagai R, Omata M.
- Journal Title
  
  J Hum Genet 48
  
  Pages: 327-330
- NAID
  10011595061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.2003
- Author(s)
  Yamauchi T, Hara K, Kubota N, Terauchi Y, Tobe K, Froguel P, Nagai R, Kadowaki T.
- Journal Title
  
  Curr Drug Targets Immune Endocr Metabol Disord 3
  
  Pages: 243-254
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.2003
- Author(s)
  Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 40352-40363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.2003
- Author(s)
  Yamauchi T, Hara K, Kubota N, Terauchi Y, Tobe K, Froguel P, Nagai R, Kadowaki T.
- Journal Title
  
  Curr Drug Targets Immune Endocr Metabol Disord 3
  
  Pages: 243-254
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Molecular mechanism of insulin resistance and obesity.2003
- Author(s)
  Kadowaki T, Hara K, Yamauchi T, Terauchi Y, Tobe K, Nagai R.
- Journal Title
  
  Exp. Biol. Med. 228
  
  Pages: 1111-1117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Establishment of a method of anonymization of DNA samples in genetic research.2003
- Author(s)
  Hara K et al.
- Journal Title
  
  J Hum Genet 48
  
  Pages: 327-330
- NAID
  10011595061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310138
[Journal Article] Establishment of a method of anonymization of DNA samples in genetic research2003
- Author(s)
  Hara K
- Journal Title
  
  J Hum Genet 48
  
  Pages: 327-330
- NAID
  10011595061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] The role of PPAR gamma in high-fat diet-induced obesity and insulin resistance.2002
- Author(s)
  Kadowaki T, Hara K, Kubota N, Tobe K, Terauchi Y, Yamauchi T, Eto K, Kadowaki H, Noda M, Hagura R, Akanuma Y.
- Journal Title
  
  J Diabetes Complications 16
  
  Pages: 41-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.2002
- Author(s)
  Hara K
- Journal Title
  
  Diabetologia 45
  
  Pages: 740-743
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] The Pro12→Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population : possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.2002
- Author(s)
  Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J, Inoue I, Seino Y, Yasuda K, Hanafusa T, Yamagata K, Awata T, Kadowaki T, Hara K, Yamada N, Gotoda T, Iwasaki N, Iwamoto Y, Sanke T, Nanjo K, Oka Y, Matsutani A, Maeda E, Kasuga M.
- Journal Title
  
  Diabetes 50
  
  Pages: 891-894
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.2002
- Author(s)
  Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T.
- Journal Title
  
  Diabetes 51
  
  Pages: 536-540
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.2002
- Author(s)
  Hara K, Noda M, Waki H, Tobe K, Yamauchi T, Kadowaki H, Satou H, Tsukamoto K, Nagamatsu S, Yamagata K, Matsuzawa Y, Akanuma Y, Kimura S, Kadowaki T.
- Journal Title
  
  Intern Med 41
  
  Pages: 848-852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.2002
- Author(s)
  Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P.
- Journal Title
  
  Hum Mol Genet 11
  
  Pages: 2607-2614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene.2002
- Author(s)
  Hara K
- Journal Title
  
  Intern Med 41
  
  Pages: 848-852
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.2002
- Author(s)
  Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, Kimura S, Kadowaki T.
- Journal Title
  
  Diabetologia 45
  
  Pages: 740-743
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.2002
- Author(s)
  Hara K
- Journal Title
  
  Diabetes 51
  
  Pages: 536-540
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects.2001
- Author(s)
  Okada T, Tobe K, Hara K, Yasuda K, Kawaguchi Y, Ikegami H, Ito C, Kadowaki T.
- Journal Title
  
  Diabetologia 44
  
  Pages: 241-244
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.2001
- Author(s)
  Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, AkanumaY, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T.
- Journal Title
  
  Nature Medicine 7
  
  Pages: 941-946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Journal Article] Association of adenovirus 36 infection with obesity and metabolic markers in humans: a meta-analysis of observational studies
- Author(s)
  Yamada T, Hara K, Kadowaki T
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-20229008
[Patent] 2型糖尿病の診断又は検査方法2002
- Inventor(s)
  原一雄, 門脇孝他3名
- Industrial Property Rights Holder
  科学技術振興事業団
- Patent Publication Number
  2004-049033
- Filing Date
  2002-07-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14013008
[Presentation] 2型糖尿病感受性遺伝子SLC16A13の機能解析2017
- Author(s)
  原　一雄
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K08631
[Presentation] Genetics of Type 2 diabetes in East Asia2011
- Author(s)
  Hara K.
- Organizer
  16th Japan-Korea Symposium on Diabetes Mellitus
- Place of Presentation
  Tokyo
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-21591124
[Presentation] Comprehensive evaluation of type 2 diabetes susceptibility in the Japanese population by genome-wide imputation analysis using the 1000 Genomes Project data2011
- Author(s)
  Hara K, Fujita H, Johnson TA, Horikoshi M, Maeda S, Tsunoda T, Kubo M, Nakamura Y, Kadowaki T.
- Organizer
  12th ICHG/61thASHG
- Place of Presentation
  montreal, Canada
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-21591124
[Presentation] 全ゲノム遺伝子発現解析をもとにした新規2型糖尿病遺伝子の同定2010
- Author(s)
  原一雄
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21591124
[Presentation] Ito C, Shojima N, Genomic Disorders 20082008
- Author(s)
  Horikoshi M, Hara K,
- Organizer
  Wellcome TrustConference Centre
- Place of Presentation
  Cambridge UK
- Data Source
  KAKENHI-PROJECT-19591038
[Presentation] Variations in the TCF7L2 and HHEXgenes independently confer Type 2 DiabetesSusceptibility on Japanese Population.68^<th> Scientific Sessions of the American2008
- Author(s)
  Horikoshi M, Hara K, Shojima N, Ito C et.al.
- Organizer
  Diabetes Association. 1146-P
- Place of Presentation
  SanFrancisco, USA.
- Data Source
  KAKENHI-PROJECT-19591038
[Presentation] Ito C, Froguel P etal. A polymorphism in the TCF7L2 isassociated with the risk of type 2 diabetesin the Japanese population. 67^<th> Scientific2007
- Author(s)
  Horikoshi M, Hara K
- Organizer
  Sessions of the American DiabetesAssociation. 1146-P
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-19591038
[Presentation] メタボリックシンドロームアディポネクチン/AdipoRの病態生理的意義2007
- Author(s)
  山内敏正, 原一雄, 窪田直人, 植木浩二郎, 戸辺一之, 門脇孝
- Organizer
  第44回日本臨床分子医学会学術総会
- Place of Presentation
  和歌山
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-18390270
[Presentation] Variations in the HHEX gene areassociated with increased risk of type 2diabetes in the Japanese population.2007
- Author(s)
  Horikoshi M, Hara K, Ito C, Shojima N et.al.
- Organizer
  FirstMeeting of EASD Study Group of Genetics ofDiabetes (EASD-SGGD)
- Place of Presentation
  Malaga, Spain.
- Data Source
  KAKENHI-PROJECT-19591038
[Presentation] Pathophysiological roles of Adiponectin and Adiponectin Receptors2007
- Author(s)
  Toshmasa Yamauchi, Naoto Kubota, Kazuo Hara, Kohjio Ueki, Kazuyuki Tobe and Takashi Kadowaki
- Organizer
  Okazaki Symposium 2007 on Obesity & Diabetes
- Place of Presentation
  Okazaki
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-18390270

1. KADOWAKI Takashi (30185889)

# of Collaborated Projects: 11 results

# of Collaborated Products: 89 results
2. YAMAUCHI Toshimasa (40372370)

# of Collaborated Projects: 8 results

# of Collaborated Products: 51 results
3. KUBOTA Naoto (50396719)

# of Collaborated Projects: 8 results

# of Collaborated Products: 32 results
4. TOBE Kazuyuki (30251242)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
5. UEKI Kohjiro (00396714)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
6. TERAUCHI Yasuo (40359609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NAGAI Ryozo (60207975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. MORITA Hiroyuki (60323573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IWATA MINORU (20345565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAEDA Shiro (50314159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 稲津正人 (00297269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 熊谷勝義 (20567911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 藤田英俊 (90571802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAMURA Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAGAWA Hajime

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKANO Atsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KATO Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TEMARU Rie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUKUSHIMA Yasuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HIGUCHI Kiyohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TAKI Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IGARASHI Yasuhumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SAWASAKI Shigeki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 今村美菜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Kazuo 原 一雄

HARA Kazuo 原 一雄

Research Projects

Research Products

Co-Researchers

Function of type 2 diabetes susceptibility genes SLC16A11/13Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of genetic architecture of type 2 diabetes using expression analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of developing metabolic syndrome by using expressionanalysis of human visceral adipose tissuePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of type 2 diabetes susceptibility genes in the Japanese population by linkage disequilibrium mapping in the chromosomal regions harboring type 2 diabetes susceptibility genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 【メタボリックシンドロームup to date】検査・診断アディポネクチン2007

Hara Kazuo 原一雄

HARA Kazuo 原一雄