Sakakibara Jun 榊原純 (小西純)

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小西純

sakakibara jun 榊原純

小西純

SAKAKIBARA Jun 榊原純(小西純)

榊原純サカキバラジュン

榊原純(小西純) サカキバラジュン

KONISHI Jun 小西純

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Researcher Number	50374278
Other IDs
Affiliation (Current)	2025: 北海道大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 大学病院, 教授 2016 – 2023: 北海道大学, 大学病院, 講師 2011 – 2014: 北海道大学, 大学病院, 助教 2011: 北海道大学, 北海道大学病院, 助教 2010: 北海道大学, 病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 58060:Clinical nursing-related / Basic Section 49020:Human pathology-related / Radiation science / Clinical nursing
Keywords	Principal Investigator 肺癌 / Notch / 治療標的 / Prox1 / 小細胞肺癌 / Numbの機能 / Numb / 組織系 / 非小細胞肺癌 / 肺扁平上皮癌 … More / 肺腺癌 / 国際情報交換 / Lung cancer / Bcl2 family / Ｂｉｍ / Ｎｏｔｃｈ / 併用治療効果 / 放射線治療 … More Except Principal Investigator RCT / 実用性試験 / 症状マネジメント / ライフサポートプログラム / 症状クラスター / 進行非小細胞肺がん / 認知行動介入 / 高度サポート開発 / 高度実践 / 進行非小細胞肺がん患者 / 患者報告型成果指標 / ユビキチン / 中皮腫 / 上皮間葉移行 / OTUB-1 / 悪性胸膜中皮腫 / OTUB1 / 脱ユビキチン化酵素 / 悪性中皮腫 / 放射線 / FMISO / 低酸素イメージング / 低酸素 / 体幹部定位放射線治療 / 原発性肺癌 / 一群事前事後テスト / リダクション Less

小細胞肺癌におけるmidkineを標的とした汎用性の高い治療開発の検討Principal Investigator
- Principal Investigator
  
  榊原純 (小西純)
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
小細胞肺癌におけるProx1によるNotch pathwayの制御機構、治療開発Principal Investigator
- Principal Investigator
  
  榊原純 (小西純)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
A project intended for new diagnostic marker and therapy for mesothelioma based on ubiquitin-proteasome system
- Principal Investigator
  
  Tanino Mishie
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
Numb has distinct roles in lung adenocarcinoma and squamous cell carcinomaus usPrincipal Investigator
- Principal Investigator
  
  sakakibara jun
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
Development and evaluation of an Advanced Support Program for Symptom Clusters for advanced non-small cell lung cancer patients
- Principal Investigator
  
  Hamada Tamami
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58060:Clinical nursing-related
- Research Institution
  Asahikawa Medical College
Real-time tumor tracking radiotherapy for patients with hypoxic primary lung cancer
- Principal Investigator
  
  INOUE TETSUYA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Life support program for symptom cluster reduction in patients with advanced non-small cell lung cancers (NSCLCs)
- Principal Investigator
  
  Hamada Tamami
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical nursing
- Research Institution
  Asahikawa Medical College
Combined antitumor effec ot g-secretase inbitiro and ABT-737Principal Investigator
- Principal Investigator
  
  SAKAKIBARA Jun
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
γ-secretase Inhibitor Enhances Antitumor Effect of Radiation in Notch Expressing Lung CancerPrincipal Investigator
- Principal Investigator
  
  SAKAKIBARA Jun (KONISHI Jun)
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University

All 2020 2019 2018 2014 2012 2010

All Journal Article Presentation

[Journal Article] Evaluating the immunoproteasome as a potential therapeutic target in cisplatin-resistant small cell and non-small cell lung cancer2020
- Author(s)
  Shoji T, Kikuchi E, Kikuchi J, Takashima Y, Furuta M, Takahashi H, Tsuji K, Maeda M, Kinoshita I, Dosaka-Akita H, Sakakibara-Konishi J, Konno S
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: in print Issue: 5 Pages: 843-853
- DOI
  10.1007/s00280-020-04061-9
- NAID
  120007032615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876, KAKENHI-PROJECT-19K23903
[Journal Article] Bromodomain and extraterminal domain inhibition synergizes with WEE1‐inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer2020
- Author(s)
  Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Suzuki Motofumi、Kikuchi Hajime、Maeda Makie、Shoji Tetsuaki、Furuta Megumi、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun、Konno Satoshi
- Journal Title
  
  International Journal of Cancer
  
  Volume: 146 Issue: 4 Pages: 1114-1124
- DOI
  10.1002/ijc.32515
- NAID
  120006958367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130, KAKENHI-PROJECT-19K23876
[Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019
- Author(s)
  Furuta Megumi、Kikuchi Hajime、Shoji Tetsuaki、Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun
- Journal Title
  
  Cancer Science
  
  Volume: in print Issue: 5 Pages: 1599-1608
- DOI
  10.1111/cas.13997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
[Journal Article] Stereotactic body radiotherapy to treat small lung lesions clinicallydiagnosed as primary lung cancer by radiological examination: a prospective observational study.2018
- Author(s)
  Tetsuya Inoue, Norio Katoh, Yoichi M Ito, Tomoki Kimura, Yasushi Nagata, Kengo Kuriyama, Hiroshi Onishi, Tadamasa Yoshitake, Yoshiyuki Shioyama, Yusuke Iizuka, Koji Inaba, Koji Konishi, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kensuke Tanaka, Jun Sakakibara-Konishi, Ichiro Kinoshita, Hiroki Shirato
- Journal Title
  
  Lung Cancer
  
  Volume: 122 Pages: 107-112
- DOI
  10.1016/j.lungcan.2018.05.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10478, KAKENHI-PROJECT-16K10378
[Journal Article] Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma2018
- Author(s)
  Kikuchi Hajime、Sakakibara-Konishi Jun、Furuta Megumi、Kikuchi Eiki、Kikuchi Junko、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Nishimura Masaharu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 50 Pages: 29379-29391
- DOI
  10.18632/oncotarget.25585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
[Journal Article] γ-secretase Inhibitor enhances antitumoreffect of radiation in Notch expressing lungcancer2012
- Author(s)
  Hidenori Mizugaki, Jun Sakakibara-Konishi, et al
- Journal Title
  
  British Journal of Cancer
  
  Volume: 106(4) Pages: 1953-1959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790742
[Journal Article] Expression of Bim, Noxa, and Puma in non-small cell lung cancer.2012
- Author(s)
  Sakakibara-Konishi J, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
- Journal Title
  
  BMC Cancer.
  
  Volume: 12 Issue: 1 Pages: 286-286
- DOI
  10.1186/1471-2407-12-286
- NAID
  120004756336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591146
[Journal Article] Notch3cooperates with the EGFR pathway to modulate apoptosis through the induction of bim2010
- Author(s)
  Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP
- Journal Title
  
  Oncogene
  
  Volume: 29(4) Pages: 589-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790742
[Presentation] Analysis of DLL3 and ASCL1 in surgically resected small cell lung cancer (HOT1702)2019
- Author(s)
  Megumi Furuta, Jun Sakakibara-Konishi, Hajime Kikuchi,
- Organizer
  AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] 小細胞肺癌切除検体におけるDLL3、ASCL1に関する検討2019
- Author(s)
  峯村　浩之、古田　恵、榊原　純
- Organizer
  日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] Analysis of DLL3 and ASCL1 in surgically resected small cell lung cancer (HOT1702)2019
- Author(s)
  Masao Harada, Megumi Furuta, Jun Sakakibara-Konishi
- Organizer
  日本臨床腫瘍学会総会
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] DLL3 regulates migration and invasion of Small Cell Lung Cancer2018
- Author(s)
  Megumi Furuta1, Jun Sakakibara-Konishi1, Tetsuaki Shoji1, Yuta Takashima1, Hajime Kikuchi 1, Eiki Kikuchi1, Junko Kikuchi1, Ichiro Kinoshita2, Hirotoshi Dosaka-Akita2, Masaharu Nishimura1
- Organizer
  AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] 肺癌におけるγセクレターゼインヒビターとBcl-2 inhibitorの併用治療効果の検討2014
- Author(s)
  榊原　純、池澤靖元、水柿秀紀、菊地順子、菊地英毅、品川尚文、大泉聡史、西村正治
- Organizer
  第55回日本肺癌学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-24591146
[Presentation] combination of g-secretase inhibitor and ABT-737 shows synergistic antitumor effect in Notch expressing lung cancer2014
- Author(s)
  榊原　純、池澤靖元、水柿秀紀、菊地順子、菊地英毅、大泉聡史、西村正治
- Organizer
  第73回日本癌学会総会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-24591146

1. KINOSHITA Ichiro (40343008)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. Hamada Tamami (00374273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 石川洋子 (30550660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 西村直樹 (60572203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. INOUE TETSUYA (10431363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Tanino Mishie (90360908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大泉聡史 (10421968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 志賀哲 (80374495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 北村秀光 (40360531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 畠山鎮次 (70294973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 伊藤俊弘 (20271760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIMURA Tomoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 永田靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakakibara Jun 榊原 純 (小西 純)

小西 純

sakakibara jun 榊原 純

小西純

SAKAKIBARA Jun 榊原 純(小西純)

榊原 純 サカキバラ ジュン

榊原 純(小西純) サカキバラ ジュン

KONISHI Jun 小西 純

Research Projects

Research Products

Co-Researchers

小細胞肺癌におけるmidkineを標的とした汎用性の高い治療開発の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小細胞肺癌におけるProx1によるNotch pathwayの制御機構、治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A project intended for new diagnostic marker and therapy for mesothelioma based on ubiquitin-proteasome system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Numb has distinct roles in lung adenocarcinoma and squamous cell carcinomaus usPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and evaluation of an Advanced Support Program for Symptom Clusters for advanced non-small cell lung cancer patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Real-time tumor tracking radiotherapy for patients with hypoxic primary lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Life support program for symptom cluster reduction in patients with advanced non-small cell lung cancers (NSCLCs)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combined antitumor effec ot g-secretase inbitiro and ABT-737Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

γ-secretase Inhibitor Enhances Antitumor Effect of Radiation in Notch Expressing Lung CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluating the immunoproteasome as a potential therapeutic target in cisplatin-resistant small cell and non-small cell lung cancer2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Bromodomain and extraterminal domain inhibition synergizes with WEE1‐inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019

Author(s)

Journal Title

Sakakibara Jun 榊原純 (小西純)

小西純

sakakibara jun 榊原純

SAKAKIBARA Jun 榊原純(小西純)

榊原純サカキバラジュン

榊原純(小西純) サカキバラジュン

KONISHI Jun 小西純