SHIMASAKI Takeo 島崎猛夫

… Alternative Names

SHIMAZAKI Takeo 島崎猛夫

島崎猛夫シマサキタケオ

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Researcher Number	50377420
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 総合医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2023: 金沢医科大学, 総合医学研究所, 准教授 2012 – 2013: 金沢医科大学, 総合医学研究所, 講師 2011: 金沢医科大学, 医学部, 講師 2007 – 2009: Kanazawa Medical University, 医学部, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 56050:Otorhinolaryngology-related / Neurosurgery / Orthopaedic surgery / General internal medicine (including Psychosomatic medicine) / Biological Sciences
Keywords	Principal Investigator EMT / 抗がん剤 / 共培養 / エクソソーム / 膵臓癌 / 浸潤性伝播 / exosome / 表面マーカー / 耐性株 / 頭頚部癌 … More / 伝播 / 浸潤 / 膵癌 / 癌細胞 / HSP90 / 膵がん / 抗癌剤 / GSK3β / 膵臓癌治療薬 / 化学療法誘導性EMT / GSK３β / 膵臓がん / ドラッグリポジショニング / 化学療法 / 遺伝子解析 / 遊走能 / 転移・浸潤 / GEMCITABINE / 塩酸ゲムシタビン … More Except Principal Investigator がん幹細胞 / GSK 3β / がん微小環境 / GSK3β / 抗癌剤治療耐性 / エクソソーム / 低濃度抗癌剤 / 細胞老化 / 治療抵抗性 / がん関連線維芽細胞 / 膵癌 / 化学予防 / STAT3 / がん悪性形質 / 逆流性食道炎 / 食道発癌 / RNA結合因子 / 神経膠腫 / 神経膠芽腫 / RNA / 腫瘍マーカー / 細胞間相互作用 / 成長板軟骨細胞 / iPS細胞 / 成長軟骨 / NLRP3 / CINCA症候群 / 抗がん剤 / 臨床 / 内科 / 癌 / 人参栄養湯 / 漢方 / 人参養栄湯 / 末梢神経障害 / オキサリプラチン / 大腸癌 / 消化器がん / 分子標的 Less

治療抵抗性膵癌のがん幹細胞性とがん関連性線維芽細胞老化を統御する分子経路の解明
- Principal Investigator
  
  宮下知治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
低濃度抗癌剤による癌細胞の動態変化とエクソソームの変化について
- Principal Investigator
  
  石坂智
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kanazawa Medical University
Inhibitor of GSK3beta impedes the development of reflux-induced esophageal cancer
- Principal Investigator
  
  Miyashita Tomoharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
  Kanazawa Medical University
Elucidation of invasive propagation of pancreatic cancer cells via exosomes and discovery of inhibitors of invasive propagationPrincipal Investigator
- Principal Investigator
  
  SHIMASAKI Takeo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa Medical University
The glioma convalescence marker development which targeted an RNA-binding factor.
- Principal Investigator
  
  NAKAMURA Yuka
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  Kanazawa Medical University
The elucidation of the molecular mechanism about the acquisition of pancreatic cancer invasion ability and application to cancer therapyPrincipal Investigator
- Principal Investigator
  
  SHIMASAKI Takeo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa Medical University
Functional analyses of mutant NLRP3 on the growth and differentiation of growth plate chondrocytes
- Principal Investigator
  
  Toguchida Junya
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
Development of the pancreatic cancer therapy by identification of EMT inducer by chemotherapyPrincipal Investigator
- Principal Investigator
  
  SHIMASAKI Takeo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa Medical University
Clinical efficacy and its molecular mechanisms of ninjinyoeito on oxaliplatin-induced peripheral neuropathy
- Principal Investigator
  
  MOTOO Yoshiharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kanazawa Medical University
GSK3βのがん促進機能の分子機構解明とその阻害に基づく消化器がん治療法の開発
- Principal Investigator
  
  源利成
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
塩酸ゲムシタビンによる膵がん細胞のEMT誘導の検証と分子細胞機構の解明Principal Investigator
- Principal Investigator
  
  島崎猛夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa Medical University

[Book] In:Colorectal cancer biology from genes to tumor2012
- Author(s)
  Minamoto T,Kotake M,Nakada M,Shimasaki T,Motoo Y,Kawakami K.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22590669
[Book] The Primo Vascular System:Its Role in Cancer and Regeneration2012
- Author(s)
  Motoo Y,Xia QS,Nakaya N,Shimasaki T,Nakajima H,Ishigaki Y.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22590669
[Journal Article] Novel platform for regulation of extracellular vesicles and metabolites secretion from cells using a multi-linkable horizontal co-culture plate2021
- Author(s)
  Shimasaki Takeo、Yamamoto Satoko、Omura Risa、Ito Kagenori、Nishide Yumiko、Yamada Hideki、Ohtomo Kazumi、Ishisaka Tomo、Okano Keiichiro、Ogawa Takenori、Tsuji Hiroyuki、Matsuo Yoichi、Minamoto Toshinari、Tomosugi Naohisa、Ferain Etienne、Ochiya Takahiro
- Journal Title
  
  Micromachines
  
  Volume: 12 Issue: 11 Pages: 1431-1431
- DOI
  10.3390/mi12111431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03727, KAKENHI-PROJECT-18K07983
[Journal Article] Exosome research and co-culture study2018
- Author(s)
  Takeo Shimasaki, Satoko Yamamoto,
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: Vol.41 No.9
- NAID
  130007479891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09051
[Journal Article] 膵癌細胞の微小環境における戦略2017
- Author(s)
  島崎猛夫
- Journal Title
  
  バイオエクスプレス
  
  Volume: 1 Pages: 2-6
- Data Source
  KAKENHI-PROJECT-15K09051
[Journal Article] High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma.2017
- Author(s)
  Higashi K, Ueda Y, Shimasaki M, Ishigaki Y, Nakamura Y, Oguchi M, Takegami T, Watanabe N.
- Journal Title
  
  Ann Nucl Med.
  
  Volume: 31（8） Issue: 8 Pages: 590-595
- DOI
  10.1007/s12149-017-1187-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15649
[Journal Article] 抗がん剤により膵癌細胞に誘導されるＥＭＴ促進因子の同定と機能解析2016
- Author(s)
  島崎猛夫、山本聡子、石垣靖人、高田尊信、有沢富康、元雄良治、友杉直久、源利成
- Journal Title
  
  膵臓
  
  Volume: 31 Pages: 76-84
- NAID
  130005137841
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09051
[Journal Article] Aberrant glycogen synthase kinase 3βis involved in pancreatic cancer cell invasion and resistance to therapy2013
- Author(s)
  Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T.
- Journal Title
  
  PLoS One
  
  Volume: 8(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591016
[Journal Article] GSK3β阻害作用を持つ医薬品を用いた難治性膵癌の新規治療法の開発2013
- Author(s)
  島崎猛夫、上田順彦、源利成
- Journal Title
  
  がん治療のあゆみ
  
  Volume: 第33巻
- Data Source
  KAKENHI-PROJECT-23591016
[Journal Article] Aberrant glycogen synthase kinase 3β in pancreatic cancer development, progression and resistance to therapy.2013
- Author(s)
  Shimasaki T, Kitano A, Motoo Y, Minamoto T
- Journal Title
  
  J Carcinog
  
  Volume: 11 Issue: 1 Pages: 15-15
- DOI
  10.4103/1477-3163.100866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-23591016, KAKENHI-PROJECT-23659643
[Journal Article] Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy2013
- Author(s)
  Kitano A
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 2 Pages: 15-15
- DOI
  10.1371/journal.pone.0055289
- URL
  http://www.kanazawa-u.ac.jp/~ganken/shuyoseigyo/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-22790542, KAKENHI-PUBLICLY-23120703, KAKENHI-PROJECT-23390321, KAKENHI-PROJECT-23590356, KAKENHI-PROJECT-23591016, KAKENHI-PROJECT-23591955, KAKENHI-PROJECT-23592117, KAKENHI-PROJECT-23659643, KAKENHI-PROJECT-25460793, KAKENHI-PROJECT-25670572
[Journal Article] Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine2012
- Author(s)
  Shimasaki T, Kawakami K, Minamoto T, et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 (3) Issue: 3 Pages: 321-33
- DOI
  10.1007/s00535-011-0484-9
- NAID
  10030560208
- URL
  http://www.kanazawa-u.ac.jp/~ganken/shuyoseigyo/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-23390321, KAKENHI-PROJECT-23591016, KAKENHI-PROJECT-23591955, KAKENHI-PROJECT-23659643
[Journal Article] Glycogen synthase kinase 3βinhibition sensitizes pancreatic cancer cells to gemcitabine2012
- Author(s)
  Shimasaki T, Ishigaki Y, Nakamura Y, Takata T, Nakaya N, Nakajima H, Sato I, Zhao X, Kitano A, Kawakami K, Tanaka T, Takegami T, Tomosugi N, Minamoto T, Motoo Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 47(3) Pages: 321-33
- NAID
  10030560208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591016
[Journal Article] ホルモン不応性前立腺癌に対するドセタキセル/UFT療法2011
- Author(s)
  島崎猛夫
- Journal Title
  
  泌尿紀要
  
  Volume: 57 Pages: 163-166
- Data Source
  KAKENHI-PROJECT-22590669
[Journal Article] Metabolic disorder, inflammation and deregulated molecular pathways converging in pancreatic cancer development: implications for new therapeutic strategies.2011
- Author(s)
  Motoo Y, et al, Minamoto T
- Journal Title
  
  Cancers
  
  Volume: 3(1) Issue: 1 Pages: 446-60
- DOI
  10.3390/cancers3010446
- NAID
  120003141569
- URL
  http://www.kanazawa-u.ac.jp/~ganken/shuyoseigyo/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249051, KAKENHI-PROJECT-22590669, KAKENHI-PROJECT-23591955, KAKENHI-PROJECT-23659643
[Journal Article] Deregulated glycogen synthase kinase 3β sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase.2009
- Author(s)
  Mai W, Kawakami K, Shimasaki T, et al., Minamoto T.
- Journal Title
  
  Clinical Cancer Research 15
  
  Pages: 6810-6819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015018
[Journal Article] An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3β.2009
- Author(s)
  Miyashita K, Shimasaki T, et al., Kawakami K, Minamoto T.
- Journal Title
  
  Anti-Cancer Agents in Medicinal Chemistry 9
  
  Pages: 1114-1122
- NAID
  120001856980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015018
[Journal Article] 消化器がんの新しい治療標的2007
- Author(s)
  源利成・島崎猛夫, 他
- Journal Title
  
  消化器科 44巻
  
  Pages: 468-467
- Data Source
  KAKENHI-PROJECT-19659190
[Journal Article] 膵癌細胞における塩酸ゲムシタビンによるアポトーシス関連遺伝子発現の変化2007
- Author(s)
  島崎猛夫, 他
- Journal Title
  
  膵臓 22巻
  
  Pages: 65-71
- NAID
  10024366179
- Data Source
  KAKENHI-PROJECT-19659190
[Patent] 膵臓癌治療剤2013
- Inventor(s)
  島崎猛夫、中田光俊、源利成
- Industrial Property Rights Holder
  学校法人金沢医科大学、国立大学法人金沢大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-093072
- Filing Date
  2013-04-25
- Overseas
- Data Source
  KAKENHI-PROJECT-23591016
[Patent] 細胞培養容器2013
- Inventor(s)
  島崎猛夫、北野裕美子、山田秀樹
- Industrial Property Rights Holder
  学校法人金沢医科大学、伸晃化学株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-164907
- Filing Date
  2013-08-08
- Overseas
- Data Source
  KAKENHI-PROJECT-23591016
[Patent] 膵臓癌治療剤2013
- Inventor(s)
  島崎　猛夫
- Industrial Property Rights Holder
  島崎　猛夫
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-093072
- Filing Date
  2013-04-25
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 膵癌細胞エクソソームの抗がん剤による動態変化とその生物学的意義2019
- Author(s)
  島崎猛夫，山本聡子，林祐一,松尾洋一, 源利成
- Organizer
  第30回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] Analysis of intracellular dynamics of exosomes and changes of surface markers2019
- Author(s)
  島崎猛夫，山本聡子，林祐一,松尾洋一, 源利成
- Organizer
  国際細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] 膵がん細胞の抗がん剤によるエクソソーム動態変化の解析2019
- Author(s)
  島崎猛夫，山本聡子，林祐一,松尾洋一, 源利成
- Organizer
  第50回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] 抗がん剤ゲムシタビンによる膵がん細胞のエクソソーム分泌及びエクソソーム表面マーカーへの影響2019
- Author(s)
  山本聡子，林祐一,松尾洋一, 源利成，島崎猛夫
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] 膵癌細胞エクソソームの抗がん剤による動態変化2019
- Author(s)
  島崎猛夫，山本聡子，林祐一,松尾洋一, 源利成
- Organizer
  第6回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] エクソソーム研究を目的とした新しい共培養容システム開発とフィルターの選択2018
- Author(s)
  島崎猛夫、山本聡子
- Organizer
  第5回細胞外小胞学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] 新しい共培養容器によるエクソソームの細胞内動態の解析2018
- Author(s)
  島崎猛夫、山本聡子
- Organizer
  日本分子生物学会第41回年会
- Data Source
  KAKENHI-PROJECT-18K07983
[Presentation] 膵癌細胞のエクソソーム動態に影響する因子の検討2017
- Author(s)
  島崎猛夫
- Organizer
  金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
- Place of Presentation
  ホテル日航金沢（石川県金沢市）
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 膵癌細胞のエクソソーム動態の解析2017
- Author(s)
  島崎猛夫、山本聡子、堂本貴寛、源利成
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 抗がん剤による膵癌細胞のエクソソーム動態への影響2017
- Author(s)
  島崎猛夫、山本聡子、堂本貴寛、清川悦子、有沢富康、源利成
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 抗がん剤による膵がん細胞のエクソソーム動態への影響2017
- Author(s)
  島崎猛夫、山本聡子、堂本貴寛、源利成
- Organizer
  第27回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 膵癌細胞のエクソソーム動態に影響する因子の検討2016
- Author(s)
  島崎猛夫
- Organizer
  第７５回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 細胞間相互作用観察が容易な新しい培養容器による新たな研究的視点2016
- Author(s)
  島崎猛夫
- Organizer
  細胞治療・再生医療実用化に向けての最前線2016
- Place of Presentation
  大手町ファーストスクエアカンファレンス（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] ゲムシタビンにより膵癌細胞に誘導されるEMT促進因子の同定と機能解析：ＧＳＫ　３β阻害による制御2015
- Author(s)
  島崎猛夫、山本聡子、源利成
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 抗がん剤により膵がん細胞に誘導される分子とエクソソームを介した細胞間相互作用の解析2015
- Author(s)
  島崎猛夫、山本聡子、源利成
- Organizer
  第26回日本消化器癌発生学会総会
- Place of Presentation
  米子全日空ホテル（鳥取県米子市）
- Year and Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] 抗癌剤により膵癌細胞に誘導されるＥＭＴ促進因子の同定と機能解析：ＧＳＫ３β阻害による制御2015
- Author(s)
  島崎猛夫、元雄良治、源利成、友杉直久
- Organizer
  第46回日本膵臓学会大会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-15K09051
[Presentation] Phase I clinical trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistant advanced pancreatic cancer patients2014
- Author(s)
  Shimasaki T, Tomosugi N, Minamoto T, et al.
- Organizer
  DDW 2014
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3βを標的治療とした既存医薬品による膵がんの新規治療2013
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第44回日本膵臓学会大会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3βis an emerging therapeutic target in pancreatic cancer : its implication for cancer cell migration and invasion2013
- Author(s)
  Shimasaki T, Ishigaki Y, Tomosugi N, Minamoto T, et al.
- Organizer
  DDW 2013
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β is an emerging therapeutic target in pancreatic cancer: its implication for cancer cell migration and invasion2013
- Author(s)
  島崎猛夫
- Organizer
  DDW　2013
- Place of Presentation
  アメリカ、オーランド、Orange County Convention Center.
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β標的治療を併用した膵癌の新規治療戦略と分子基盤2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第20回JDDW
- Place of Presentation
  神戸国際展示場・ポートピアホテル・神戸こうくさい会議場
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 膵癌の新規治療標的としてのglycogen synthase kinase (GSK) 3β:がん浸潤に対する作用2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β標的治療と化学療法を併用する膵がんの新規治療戦略と分子基盤2012
- Author(s)
  島崎猛夫,石垣靖人,源利成,友杉直久他
- Organizer
  第43回日本膵臓学会大会
- Place of Presentation
  ホテルメトロポリタン山形
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] ゲムシタビン単剤療法の壁への挑戦: 新規標的分子の同定と膵癌化学療法への展望2011
- Author(s)
  島崎猛夫
- Organizer
  第42回日本膵臓学会大会
- Place of Presentation
  ホテルニューキャッスル（青森県）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 膵癌の新規治療標的としてのglycogen synthase kinase (GSK) 3β:化学療法戦略の新展開2011
- Author(s)
  島崎猛夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 切除不能進行膵癌に対するGSK3βを標的とした新規治療戦略2011
- Author(s)
  島崎猛夫
- Organizer
  第53回日本消化器病学会大会
- Place of Presentation
  マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 微粒子可視化装置を用いたシミュレーションによる抗がん剤調整時の暴露状況の検討2011
- Author(s)
  島崎猛夫
- Organizer
  第9回日本臨床腫瘍学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 切除不能進行膵癌に対するGSK3βを標的とした新規治療戦略2011
- Author(s)
  島崎猛夫
- Organizer
  第53回日本消化器病学会大会
- Place of Presentation
  マリンメッセ福岡(福岡県)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 膵癌の新規治療標的としてのglycogen synthase kinase(GSK)3β: 化学療法戦略の新展開2011
- Author(s)
  島崎猛夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] ホルモン不応性前立腺癌に対するドセタキセル/UFT療法2011
- Author(s)
  島崎猛夫
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 障癌細胞におけるgemcitabine誘導性EMTに関連する新規分子の同定2011
- Author(s)
  島崎猛夫
- Organizer
  第22回日本消化器癌発生学会
- Place of Presentation
  ホテルニューオータニ佐賀(佐賀県)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 膵癌細胞におけるgemcitabine誘導性EMTに関連する新規分子の同定2011
- Author(s)
  島崎猛夫
- Organizer
  第22回日本消化器癌発生学会
- Place of Presentation
  ホテルニューオータニ佐賀（佐賀県）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] ゲムシタビン単剤療法の壁への挑戦:新規標的分子の同定と膵癌化学療法への展望2011
- Author(s)
  島崎猛夫
- Organizer
  第42回日本膵臓学会大会
- Place of Presentation
  ホテルニューキャッスル(青森県)
- Year and Date
  2011-07-29
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] 膵癌細胞の抗がん剤誘導性上皮間葉移行とGSK38阻害による制御機構2010
- Author(s)
  島崎猛夫
- Organizer
  第21回日本消化器癌発生学会総会
- Place of Presentation
  軽井沢プリンスホテル(長野県)
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22590669
[Presentation] Glycogen synthase kinase(GSK)3β sustains colon cancer cells survival by modulating JNK-mediated pathway.2009
- Author(s)
  Jin M, Kawakami K, Shimasaki T, et al., Minamoto T
- Organizer
  第68回日本癌学会繊学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] GSK3βによる膵がん細胞の増殖と浸潤の制御.2009
- Author(s)
  北野綾子, 島崎猛夫, ほか, 川上和之, 源利成
- Organizer
  第20回消化器癌発生学会総会:ミニシンポジウム(5)-3消化器癌の分子基盤:浸潤・転移-3
- Place of Presentation
  オリエンタルホテル広島(広島県)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] 膵癌に対する塩酸ゲムシタビンとGSK 3 β阻害剤併用の抗腫瘍効果とマイクロアレイ及びマイクロRNAによる解析2009
- Author(s)
  島崎猛夫
- Organizer
  第6回日本臨床腫瘍学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] Chemotherapy-induced changes in morphology and invasion ability of pancreatic cancer cells2009
- Author(s)
  Shimasaki T, Kawakami K, Minamoto T, et al.
- Organizer
  第68回日本癌学会総会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] Pathological roles for glycogen synthase kinase(GSK)3β in proliferation and motility of pancreatic cancer cells2009
- Author(s)
  Kitano A, Shimasaki T, et al., Kawakami K, Minamoto T
- Organizer
  第68回日本癌学会総会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] GSK3β阻害剤と塩酸ゲムシタビンの併用による膵癌の新規治療戦略と分子基盤.2009
- Author(s)
  島崎猛夫, 川上和之, 源利成, ほか
- Organizer
  第40回日本膵臓病学会大会,シンポジウム2
- Place of Presentation
  京王プラザホテル(東京都)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] GSK3β阻害による抗がん剤誘導性上皮-間葉移行の制御に基づく新規膵癌治療ストラテジー.2009
- Author(s)
  島崎猛夫, 川上和之, 源利成, ほか
- Organizer
  第20回消化器癌発生学会総会:シンポジウム(2)消化器癌治療の新展開
- Place of Presentation
  オリエンタルホテル広島(広島県)
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] 膵癌の臨床試験を目指したGSK3β阻害剤と塩酸ゲムシタビンの併用療法に関する基礎的解析2008
- Author(s)
  島崎猛夫, 川上和之, 源利成, ほか
- Organizer
  第19回日本消化器癌発生学会総会
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] 癌に対するGSK3β阻害剤とジェムシタビンによる治療効果 : 臨床試験を目指した基礎的検討2008
- Author(s)
  島崎猛夫
- Organizer
  日本癌学会学術総会(シンポジウム)
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] 膵癌における新しい分子標的としてのGSK3βとその関連遺伝子群の解析2008
- Author(s)
  島崎猛夫
- Organizer
  第19回日本消化器癌発生学会総会(シンポジウム)
- Place of Presentation
  別府
- Year and Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] Combined effect of gemcitabine and GSK3β inhibitor against pancreatic cancer : basic analysis for future clinical trial2008
- Author(s)
  Shimasaki T, Kawakami K, et.al., Minamoto T
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20015018
[Presentation] Combined effect of gemcitabine and GSK3β inhibitor against human pancreas cancer : GSK3β as a new therapeutic molecular target2007
- Author(s)
  島崎猛夫, 他
- Organizer
  38th Annual Meeting of the American Pancreatic Association
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] 膵癌に対する塩酸ゲムシタビンとGSK3β阻害剤併用の抗腫瘍効果とその分子機構2007
- Author(s)
  島崎猛夫, 他
- Organizer
  第38回日本膵臓学会大会シンポジウム
- Place of Presentation
  博多
- Year and Date
  2007-06-29
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] Combined effect of gemcitabine and GSK3β ; inhibitor against human pancreas cancer : GSK3β ; as a new therapeutic target2007
- Author(s)
  島崎猛夫, 他
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] 膵癌に対する塩酸ゲムシタビンとGSK3β阻害剤併用の抗腫瘍効果とその分子機構2007
- Author(s)
  島崎猛夫, 他
- Organizer
  第18回消化器癌発生学会ワークショップ
- Place of Presentation
  札幌
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19659190
[Presentation] GSK3βの異常活性に起因する膵がん細胞の浸潤と治療抵抗性
- Author(s)
  島崎猛夫
- Organizer
  第10回日本臨床腫瘍学会学術集会
- Place of Presentation
  大阪（大阪国際会議場）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β標的治療と化学療法を併用する膵がんの新規治療戦略と分子基盤
- Author(s)
  島崎猛夫
- Organizer
  第43回日本膵臓学会大会
- Place of Presentation
  山形（ホテルメトロポリタン山形）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] 膵癌の新規治療標的としてのglycogen synthase kinase(GSK)3Bβ: がん浸潤に対する作用
- Author(s)
  島崎猛夫
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌(札幌市教育文化会館）
- Data Source
  KAKENHI-PROJECT-23591016
[Presentation] GSK3β標的治療を併用した膵癌の新規治療戦略と分子基盤
- Author(s)
  島崎猛夫
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  神戸(神戸国際展示場)
- Data Source
  KAKENHI-PROJECT-23591016

1. MINAMOTO Toshinari (50239323)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
2. ISHIGAKI Yasuhito (20232275)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
3. MOTOO Yoshiharu (80210095)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. TOMOSUGI Naohisa (80155580)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. NAKAMURA Yuka (00565632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. Miyashita Tomoharu (30397210)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 山本聡子 (00768161)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
8. SAIKI Ikuo (80133776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKANO Fumihide (20236251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAKINO Toshikaki (80326561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OCHIYA Takahiro (60192530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Toguchida Junya (40273502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AKAI Takuya (50222500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKADA Mitsutoshi (20334774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKADA Satoko (30569091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 川上和之 (00293358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
17. 池谷真 (20442923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 金永輝 (90620344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 太田哲生 (40194170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高村博之 (40377396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 石坂智 (70862530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 小川武則 (50375060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 北村守正 (60543262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 松尾洋一 (40381800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

SHIMASAKI Takeo 島崎 猛夫

SHIMAZAKI Takeo 島崎 猛夫

島崎 猛夫 シマサキ タケオ

Research Projects

Research Products

Co-Researchers

治療抵抗性膵癌のがん幹細胞性とがん関連性線維芽細胞老化を統御する分子経路の解明

Principal Investigator

Project Period (FY)

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低濃度抗癌剤による癌細胞の動態変化とエクソソームの変化について

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Inhibitor of GSK3beta impedes the development of reflux-induced esophageal cancer

Principal Investigator

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Review Section

Research Institution

Elucidation of invasive propagation of pancreatic cancer cells via exosomes and discovery of inhibitors of invasive propagationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The glioma convalescence marker development which targeted an RNA-binding factor.

Principal Investigator

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Research Institution

The elucidation of the molecular mechanism about the acquisition of pancreatic cancer invasion ability and application to cancer therapyPrincipal Investigator

Principal Investigator

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Functional analyses of mutant NLRP3 on the growth and differentiation of growth plate chondrocytes

Principal Investigator

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Development of the pancreatic cancer therapy by identification of EMT inducer by chemotherapyPrincipal Investigator

Principal Investigator

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Research Institution

Clinical efficacy and its molecular mechanisms of ninjinyoeito on oxaliplatin-induced peripheral neuropathy

Principal Investigator

Project Period (FY)

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Research Institution

GSK3βのがん促進機能の分子機構解明とその阻害に基づく消化器がん治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

塩酸ゲムシタビンによる膵がん細胞のEMT誘導の検証と分子細胞機構の解明Principal Investigator

Principal Investigator

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Research Institution

[Book] In:Colorectal cancer biology from genes to tumor2012

Author(s)

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[Book] The Primo Vascular System:Its Role in Cancer and Regeneration2012

Author(s)

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Data Source

SHIMASAKI Takeo 島崎猛夫

SHIMAZAKI Takeo 島崎猛夫

島崎猛夫シマサキタケオ