OOSHIRO Hiroko 大城浩子

… Alternative Names

OSHIRO Hiroko 大城浩子

HONNA Hiroko 本名浩子

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Researcher Number	50377537
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 医学研究員
Affiliation (based on the past Project Information) *help	2018 – 2024: 山梨大学, 大学院総合研究部, 医学研究員 2015: 山梨大学, 総合研究部, 助教 2011: 山梨大学, 医学部・附属病院, 助教 2011: 山梨大学, 医学部附属病院, 助教 2010: 山梨大学, 医学部・附属病院, 医員 … More 2010: 山梨大学, 医学部附属病院, 医員 2008 – 2009: University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 2008: University of Yamanashi, 大学院医学工学総合研究部, 医学研究員 2007: University of Yamanashi, 医学部・附属病院, 医員 2006: University of Yamanashi, University of Yamanashi Hospital, Medical Staff, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Biological Sciences
Keywords	Principal Investigator KIRリガンド不一致 / 臍帯血移植 / 急性リンパ性白血病 / NK細胞 / KIR ligand不一致 / alloreactivity / graft-versus-leukemia効果 Except Principal Investigator 白血病 / 急性リンパ性白血病 / 個別化治療 … More / ゲノム編集 / 薬剤感受性 / 難治性 / CD33 / NK細胞 / E2A-HLF / 17;19転座 / アポトーシス / 細胞傷害因子 / ゲノム編集技術 / ゲノム解析 / ゲノム情報 / がんゲノム / さい帯血 / TGF-β / 抗腫瘍効果 / 小児悪性腫瘍 / 小児難治性固形腫瘍 / TGF－β阻害剤 / TGF－β / 小児難治性腫瘍 / ALL / ヒアルロン酸 / ネクローシス / 細胞死 / CD44 / 超低分子量ヒアルロン酸 / LMO2 / t(17;19) / cytotoxic ligand / 11q23 translocation / apoptosis / childhood leukemia / FLT-3遺伝子 / PKC412 / BCR-ABL / Imatinib / 11q23転座型白血病 / Philadelphia染色体陽性白血病 / 難治性小児白血病 / 分子標的療法 / 細胞周期 / LMO2遺伝子 / 難治性白血病 / LM02 / 11q23転座 / 小児白血病 / 臍帯血 / KIRリガンド / GVL効果 / 同種移植 / KIR / 難治性腫瘍 / TRAIL / 細胞障害因子 / DR5受容体 / DR4 / 移植片対白血病効果 Less

難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究
- Principal Investigator
  
  犬飼岳史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia
- Principal Investigator
  
  Inukai Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
Enhancement of the antitumor effect of allogeneic NK cells by inhibition of TGF-beta pathway
- Principal Investigator
  
  GOI Kumiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Yamanashi
CD44-targetted therapy for CD44-high expressing tumors by ultra-low-molecular-weight hyaluronan
- Principal Investigator
  
  SUGITA Kanji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
The study of graft-versus-leukemia effect of cord blood NK cells Against refractory childhood leukemiaPrincipal Investigator
- Principal Investigator
  
  OHSHIRO Hiroko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
The cytotoxic effect by natural killer cells against pediatric malignant tumors.
- Principal Investigator
  
  GOI Kumiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
The study of graft-versus-leukemia (GVL) effect of NK cells from umbilical cord blood (CB)Principal Investigator
- Principal Investigator
  
  HONNA Hiroko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi
細胞傷害因子の移植片対白血病効果における意義と臨床応用に向けた研究
- Principal Investigator
  
  INUKAI Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Yamanashi
Establishment of new-therapy and analysis of mechanisms for resistance to apoptosis in poor-prognostic childhood leukemia
- Principal Investigator
  
  NAKAZAWA Shinpei
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  University of Yamanashi

All 2022 2019 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022
- Author(s)
  Akahane Koshi、Watanabe Atsushi、Somazu Shinpei、Harama Daisuke、Shinohara Tamao、Kasai Shin、Oshiro Hiroko、Goi Kumiko、Hasuda Norio、Ozawa Chihiro、Sugita Kanji、Inukai Takeshi
- Journal Title
  
  Medicine
  
  Volume: 101 Issue: 11
- DOI
  10.1097/md.0000000000029054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.2019
- Author(s)
  Akahane K, Watanabe A, Furuichi Y, Somazu S, Oshiro H, Goi K, Sakashita K, Muramatsu H, Hama A, Takahashi Y, Koike K, Kojima S, Sugita K, Inukai T.
- Journal Title
  
  Pediatr Transplant.
  
  Volume: 3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615
[Journal Article] Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.2019
- Author(s)
  Watanabe A, Inukai T, Kagami K, Abe M, Takagi M, Fukushima T, Fukushima H, Nanmoku T, Terui K, Ito T, Toki T, Ito E, Fujimura J, Goto H, Endo M, Look T, Kamps M, Minegishi M, Takita J, Inaba T, Takahashi H, Ohara A, Harama D, Shinohara T, Somazu S, Oshiro H, Akahane K, Goi K, Sugita K.
- Journal Title
  
  Cancer Med.
  
  Volume: 7 Issue: 11 Pages: 5274-5288
- DOI
  10.1002/cam4.2356
- NAID
  120007159553
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04039, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K19467
[Journal Article] Successful tandem (autologous-cord blood) SCT in advanced neuroblastomas with highly amplified MYCN.2010
- Author(s)
  Goi K, Inukai T, Honna H, et al
- Journal Title
  
  Bone Marrow Transplant.[Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591249
[Journal Article] 9;11転座を有するCD10陽性急性リンパ性白血病2010
- Author(s)
  本名(大城)浩子
- Journal Title
  
  日本小児血液学会雑誌
  
  Volume: 24巻 Pages: 97-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790971
[Journal Article] Revision of the cytological diagnosis of CNS relapse into aseptic meningitis in a patient with TEL-AMLI-positive acute lymphoblastic leukaemia by FISH analysis of mononuclear cells in cerebrospinal fluid2007
- Author(s)
  Inukai T, Akahane K, Kuroda I, Honna H, Sugita K, ら
- Journal Title
  
  Histopathology 50
  
  Pages: 947-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Monitoring neutrophil engraftment in allogeneic stem cell transplantation by flow cytometric analysis of neutrophil-specific antigens NA1 and NA22007
- Author(s)
  Inukai T, Akahane K, Honna H, Sugita K, ら
- Journal Title
  
  Br J Haematol 139
  
  Pages: 280-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Fms-like Tyrosine Kinase 3 Ligand Stimulation Induces MLL-Rearranged Leukemia Cells into Quiescence Resistant to Antileukemic Agents2007
- Author(s)
  Furuichi Y, Inukai T, Akahane K, Honna H, Kuroda I, Sugita K, ら
- Journal Title
  
  Cancer Res. 67
  
  Pages: 9852-9861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Resistance of infant leukemia with MLL rearrangement to TNF-related apoptosis-induc ng ligand : a possible mechanism for poor sensitivity to antitumor immunity.2006
- Author(s)
  Inukai T, Hirose K, Goi K, Honna H, T, Nakazawa S, Sugita K, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 2119-2129
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390297
[Journal Article] Natural pregnancy and delivery after allogeneic bone marrow transplantation in a Fanconi anaemia patient.2006
- Author(s)
  Goi K, Sugita K, Inukai T, Honna H, Hirose K, Nakazawa S, et al.
- Journal Title
  
  British Journal of Haematology 135
  
  Pages: 410-411
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390297
[Journal Article] Resistance of infant leukemia with MLL rearrangement to TNF-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antiumor immunity.2006
- Author(s)
  Inukai T, Hirose K, Goi K, Honna H, T, Nakazawa S, Sugita K, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 2119-2129
- Data Source
  KAKENHI-PROJECT-16390297
[Journal Article] Natural pregnancy and delivery after allogeneic bone marrow transplantation in a Fanconi anaemia patient.2006
- Author(s)
  Goi K, Sugita K, Nakamura M, Inukai T, Honna H, Hirose K, Kuroda I, Hoshi K, Nakazawa S
- Journal Title
  
  British Journal of Haematology 135
  
  Pages: 410-411
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Resistance of infant leukemia with MLL rearrangement to TNF-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antitumor immunity.2006
- Author(s)
  Inukai T, Hirose K, Goi K, Honna H, T, Nakazawa S, Sugita K, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 2119-2129
- Data Source
  KAKENHI-PROJECT-18015020
[Journal Article] Resistance of infant leukemia with MLL rearrangement to TNF-related apoptosis-inducing ligand : a possible mechanism for poor sensitivity to antitumor immunity.2006
- Author(s)
  Inukai T, Hirose K, Goi K, Honna H, T, Nakazawa S, Sugita K, et al.
- Journal Title
  
  Leukemia 20
  
  Pages: 2119-2129
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390297
[Journal Article] Natural pregnancy and delivery after allogeneic bone marrow transplantation in a Fanconi anaemia patient.2006
- Author(s)
  Goi K, Sugita K, Nakamura M, Inukai T, Honna H, Hirose K, Kuroda I, Hoshi K, Nakazawa S.
- Journal Title
  
  British Journal of Haematology 135
  
  Pages: 410-411
- Data Source
  KAKENHI-PROJECT-16390297
[Presentation] Eculizumab treatment followed by U-BMT for a pediatric PNH/AA patient2011
- Author(s)
  大城浩子
- Organizer
  日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22790971
[Presentation] Eculizumab treatment followed by U-BMT for a pediatric PNH/AA patient2011
- Author(s)
  大城浩子
- Organizer
  日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22790971
[Presentation] 2回目の同種移植7年後にALLの骨髄局所再発を来した1男児例2011
- Author(s)
  大城浩子
- Organizer
  日本小児血液・がん学会学術集会
- Place of Presentation
  前橋ベイシア文化ホール
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790971
[Presentation] 2回目の同種移植7年後にALLの骨髄局所再発を来した1男児例2011
- Author(s)
  大城浩子
- Organizer
  日本小児血液・がん学会学術集会
- Place of Presentation
  前橋ベイシア文化ホール(群馬県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790971
[Presentation] The cytotoxicity of cord blood NK cells against MLL-rearramged ALL is associated with SNPs of NKG2D2010
- Author(s)
  本名浩子、合井久美子
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-20591249
[Presentation] The cytotoxicity of cord blood NK cells against MLL-rearramged ALL is associated with SNPs of NKG2D2010
- Author(s)
  本名(大城)浩子
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790971
[Presentation] 同種臍帯血NK細胞のT 細胞性急性リンパ性白血病に対する細胞傷害活性に関する検討2009
- Author(s)
  本名浩子、合井久美子
- Organizer
  日本小児血液学会
- Place of Presentation
  千葉県浦安市
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20591249
[Presentation] 同種臍帯血NK細胞のT細胞性急性リンパ性白血病に対する細胞傷害活性に関する検討2009
- Author(s)
  本名浩子
- Organizer
  日本児血液学会
- Place of Presentation
  千葉県浦安市
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20591249
[Presentation] 同種臍帯血NK細胞のMLL遺伝子再構成陽性ALLに対する細胞傷害活性に関する検討2008
- Author(s)
  本名浩子、合井久美子
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591249
[Presentation] 同種臍帯血NK細胞のMLL遺伝子再構成陽性ALLに対する細胞傷害活性に関する検討2008
- Author(s)
  本名浩子
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19790711
[Presentation] 同種臍帯血NK細胞のMLL遺伝子再構成陽性ALLに対する細胞傷害活性に関する検討2008
- Author(s)
  本名浩子、合井久美子、廣瀬衣子、黒田格、犬飼岳史、加賀美恵子、中澤眞平、杉田完爾
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19790711
[Presentation] 11q23転座型白血病に対する同種NK細胞の抗腫瘍効果の検討2007
- Author(s)
  本名浩子、合井久美子、廣瀬衣子、黒田格、犬飼岳史、加賀美恵子、佐藤広樹、中澤眞平、杉田完爾
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-19790711
[Presentation] 11q23転座型白血病に対する同種NK細胞の抗腫瘍効果の検討2007
- Author(s)
  本名浩子
- Organizer
  American society of hematology
- Place of Presentation
  アメリカ,アトランタ
- Data Source
  KAKENHI-PROJECT-19790711
[Presentation] 11q23転座型白血病に対する同種NK細胞の抗腫瘍効果の検討2007
- Author(s)
  本名浩子、合井久美子、廣瀬衣子、黒田格、犬飼岳史、加賀美恵子、杉田完爾
- Organizer
  American society of hematology
- Place of Presentation
  アメリカ、アトランタ
- Data Source
  KAKENHI-PROJECT-19790711

1. GOI Kumiko (70324192)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. INUKAI Takeshi (30293450)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
3. AKAHANE Koshi (90377531)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. SUGITA Kanji (60138055)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 原間大輔 (10774078)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. NAKAZAWA Shinpei (90090034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 黒田格 (30402051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 渡邊敦 (30610498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 篠原珠緒 (80747452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 玉井望雅 (90747453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 伊藤悦朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 照井君典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 土岐力

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OOSHIRO Hiroko 大城 浩子

OSHIRO Hiroko 大城 浩子

HONNA Hiroko 本名 浩子

Research Projects

Research Products

Co-Researchers

難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhancement of the antitumor effect of allogeneic NK cells by inhibition of TGF-beta pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CD44-targetted therapy for CD44-high expressing tumors by ultra-low-molecular-weight hyaluronan

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of graft-versus-leukemia effect of cord blood NK cells Against refractory childhood leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The cytotoxic effect by natural killer cells against pediatric malignant tumors.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of graft-versus-leukemia (GVL) effect of NK cells from umbilical cord blood (CB)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞傷害因子の移植片対白血病効果における意義と臨床応用に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of new-therapy and analysis of mechanisms for resistance to apoptosis in poor-prognostic childhood leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful treatment of intractable gastrointestinal tract graft-vs-host disease with oral beclomethasone dipropionate in pediatric and young adult patients2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful hematopoietic stem cell transplantation from an HLA-mismatched parent for engraftment failure after unrelated cord blood transplantation in patients with juvenile myelomonocytic leukemia: Report of two cases.2019

Author(s)

Journal Title

Data Source

[Journal Article] Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Successful tandem (autologous-cord blood) SCT in advanced neuroblastomas with highly amplified MYCN.2010

Author(s)

Journal Title

Data Source

[Journal Article] 9;11転座を有するCD10陽性急性リンパ性白血病2010

OOSHIRO Hiroko 大城浩子

OSHIRO Hiroko 大城浩子

HONNA Hiroko 本名浩子