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Yamashita Atsuo  山下 敦生

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YAMASHITA Atsuo  山下 敦生

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Researcher Number 50379971
Other IDs
Affiliation (Current) 2025: 山口大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 山口大学, 大学院医学系研究科, 准教授
2021: 山口大学, 医学部附属病院, 准教授
2017 – 2020: 山口大学, 医学部附属病院, 講師
2007 – 2017: 山口大学, 医学部附属病院, 助教
2007 – 2009: Yamaguchi University, 医学部・附属病院, 助教
2006: Yamaguchi Univ., Hospital, Research Associate, 医学部附属病院, 助手
2005: 山口大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology
Except Principal Investigator
Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology
Keywords
Principal Investigator
脳・神経 / 胸腹部大動脈瘤 / 脊髄虚血保護 / 麻酔科学 / 再灌流障害 / 脊髄虚血 / 側副血行 / 対麻痺 / 炎症反応 / 脳・神経科学 … More / 虚血 / 脊髄 / 高二酸化炭素血症 / 脊髄血流 / 交感神経遮断 / 傍脊椎神経ブロック / 神経ブロック / サイトカイン / 血管新生 / 大動脈瘤手術 / 周術期管理 / 神経保護 / 脳・脊髄・神経 / インフリキシマブ / 抗TNF-α抗体 / 遅発性対麻痺 / 神経科学 / 麻酔学 / 予防医学 … More
Except Principal Investigator
脊髄虚血 / 家兎 / 術後高次脳機能障害 / インスリン様成長因子1 / リラグルチド / Glucagon-like peptide 1 / insulin / paraplegia / rabbit / spinal cord ischemia / インスリン / 脳血管炭酸ガス反応性 / 脳虚血 / エリスロポエチン / グルカゴン様ペプチド1 / グルカゴン様ペプチド-1受容体作動薬 / エクセナチド / Liraglutide / Exendin-4 / Glucagon-like peptide-1 / 脊髄保護 / 人工心肺 / 大動脈弁置換術 / 動脈硬化病変 / インターロイキン6 / 心臓大血管手術 / アクロレイン / Basal lamina / Astrocyte / Vascular endothelial growth factor / Fat emboli / Brain ischemia / Brain edema / 血管内皮増速因子 / basal lamina / アストロサイト / 血管内皮増殖因子 / 脂肪塞栓 / 脳浮腫 / insulin-like growth factor-1 / insulin-like growth factor1 / 対麻痺 / 脳血管反応性 / 心臓手術 / EPA/AA比 / アラキドン酸 / エイコサペンタエン酸 / off-pump CABG / 非対称性ジメチルアルギニン / L-arginine / 非対称性ジメチルアルギニン(ADMA) / クレアチニン / 尿素窒素 / 腎障害 / 硬膜外電気刺激 / 脊髓虚血 / Akt / 内非依存性弛緩反応 / 活性酸素種 / 内皮依存性弛緩反応 / 脳血流 / 免疫ブロッティング法 / HE染色 / 海馬 / プロテアソーム / スナネズミ / 前脳虚血 / 神経細胞傷害 / 虚血耐性 Less
  • Research Projects

    (18 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (11 People)
  •  Investigation of spinal blood flow elevation for hypercapnia and protective effect of spinal cord ischemiaPrincipal Investigator

    • Principal Investigator
      山下 敦生
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Yamaguchi University
  •  血糖コントロールを重視したAkt2活性化による新たな脊髄保護法の開発

    • Principal Investigator
      松本 美志也
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Yamaguchi University
  •  Research of the protective strategy against spinal cord ischemia focus on an increase in spinal cord blood flow due to sympathetic blockade upon paravertebral block.Principal Investigator

    • Principal Investigator
      YAMASHITA Atsuo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Yamaguchi University
  •  Spinal cord protection using glucagon-like peptide-1 receptor agonists

    • Principal Investigator
      Matsumoto Mishiya
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Yamaguchi University
  •  Research of inflammatory responses with the progress of ischemic spinal cord injury.Principal Investigator

    • Principal Investigator
      YAMASHITA Atsuo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Yamaguchi University
  •  体内細胞毒性アルデヒド、アクロレインが心臓術後高次脳機能障害に与える影響

    • Principal Investigator
      石田 和慶
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Yamaguchi University
  •  The strategy of protection against ischemic spinal cord injury by development of perivertebral collateral circulation through segmental artery ligation.Principal Investigator

    • Principal Investigator
      YAMASHITA Atsuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Yamaguchi University
  •  The association of eicosapentaenoic acid and arachidonic acid ratio to the cerebrovascular CO2 reactivity and development of postoperative cognitive dysfunction in cardiac surgery

    • Principal Investigator
      ISHIDA KAZUYOSHI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Yamaguchi University
  •  Evaluation for clinical utilization of anti-inflammatory agents in spinal cord ischemia.Principal Investigator

    • Principal Investigator
      YAMASHITA Atsuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  Influence of circulating asymmetric dimethylarginine on cerebrovascular reactivity during general anesthesia and developingof postoperative cognitive dysfunction

    • Principal Investigator
      ISHIDA Kazuyoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  Spinal cord protection by the activation of Akt(protein kinase B)

    • Principal Investigator
      MATSUMOTO Mishiya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  The influence of inflammatory mediators on the pathophysiology of delayed paraplegia after spinal cord ischemia.Principal Investigator

    • Principal Investigator
      YAMASHITA Atsuo
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  Effects of erythropoietin and insulin-like growth factor 1 on the outcome after transient spinal cord ischemia and the mechanism in the signal transduction

    • Principal Investigator
      MATSUMOTO Mishiya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  The effects of reactive oxygen species on the cerebral vascular reactivity after transient cerebral ischemia

    • Principal Investigator
      IIDA Yasuhiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  ヒスチジン・ヒスタミンによる抗炎症作用と脊髄保護効果に関する研究Principal Investigator

    • Principal Investigator
      山下 敦生
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  プロテアソームを介する虚血耐性現象の獲得に関する研究

    • Principal Investigator
      FUKUDA Shiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  A new role of insulin in the protection against ischemic spinal cord injury

    • Principal Investigator
      MATSUMOTO Mishiya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University
  •  The contribution and modulation of vascular endothelial growth factor for brain edema formation

    • Principal Investigator
      IIDA Yasuhiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamaguchi University

All 2024 2023 2022 2020 2013 2012 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] 麻薬は虚血性脊髄障害を増悪させない2012

    • Author(s)
      松本美志也、白澤由美子、石田和慶、福田志朗、山下敦生
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 32巻 Pages: 359-365

    • NAID

      10030763200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591974
  • [Journal Article] Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?2009

    • Author(s)
      Yumiko Shirasawa, Mishiya Matsumoto, Manabu Yoshimura, Atsuo Yamashita, Shiro Fukuda, Kazuyoshi Ishida, Takefumi Sakabe
    • Journal Title

      J Anesth

      Volume: vol23 Pages: 242-248

    • NAID

      10025382229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591974
  • [Presentation] グルカゴン様ペプチド1受容体作動薬とインスリンの併用による脊髄保護効果2024

    • Author(s)
      山下敦生、山下理、松本美志也
    • Organizer
      日本麻酔科学会第71回学術集会
    • Data Source
      KAKENHI-PROJECT-22K09096
  • [Presentation] グルカゴン様ペプチド1受容体作動薬とインスリンの併用による脊髄保護効果2023

    • Author(s)
      山下敦生、山下理、若松弘也、松本美志也
    • Organizer
      日本麻酔科学会第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K09096
  • [Presentation] グルカゴン様ペプチド1受容体作動薬による脊髄保護と遺伝子発現2022

    • Author(s)
      山下敦生、山下理、若松弘也、松本美志也
    • Organizer
      日本麻酔科学会第69回大会
    • Data Source
      KAKENHI-PROJECT-19K09327
  • [Presentation] Glucagon-like peptide-1受容体作動薬による脊髄保護効果2020

    • Author(s)
      山下敦生、松本美志也
    • Organizer
      日本麻酔科学会第67回学術集会
    • Data Source
      KAKENHI-PROJECT-19K09327
  • [Presentation] Influence of circulating asymmetric dimethylarginine and arginine concentrations on cerebrovascular CO_2reactivity during general anesthesia in patients with chronic renal failure2013

    • Author(s)
      Ishida K、Yamashita A、Matsumoto M et al
    • Organizer
      Submitted to 2013 annual meeting of American society of anesthesiologists
    • Place of Presentation
      San Francisco (USA)
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] 腎障害患者における血中非対称性ジメチルアルギニンおよびアルギニン値が全身麻酔中の脳血管炭酸ガス反応性に与える影響2013

    • Author(s)
      石田和慶、山下敦生、松本美志也他
    • Organizer
      第17回日本神経麻酔・集中治療研究会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2013-04-13
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] Association between change in intraoperative regional cerebral oxygen saturation and development of postoperative cognitive dysfunction after off-pump coronary artery bypass graft surgery2012

    • Author(s)
      Ishida K、Yamashita A、Matsumoto M et al
    • Organizer
      Society for neuroscience in anesthesiology and critical care 40thAnnual Meeting
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2012-10-12
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] 人工心肺を用いない冠動脈バイパス術での術後高次脳機脳障害と術中局所脳酸素飽和度、microembolic signalsとの関連2012

    • Author(s)
      石田和慶、山下敦生、松本美志也他
    • Organizer
      第15回日本栓子検出と治療学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2012-10-06
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] 人工心肺を用いない冠動脈バイパス術での術中術局所脳酸素飽和度の変化と術後高次脳機能障害2012

    • Author(s)
      石田和慶、山下敦生、松本美志也
    • Organizer
      日本心臓血管麻酔学会第17回学術大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2012-09-15
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] Postoperative cognitive dysfunction in patients after off-pump coronary artery bypass graft under regional cerebral oxygen monitoring2012

    • Author(s)
      Ishida K、Yamashita A、 Matsumoto M et al
    • Organizer
      The 3rdinternational symposium for cardiac anesthesia. Sendai symposium
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2012-09-14
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] 人工心肺を用いない冠動脈バイパス術(off-pump CABG)における術後高次脳機能障害と局所脳酸素飽和度2012

    • Author(s)
      石田和慶、山下敦生、松本美志也
    • Organizer
      第18回日本脳代謝モニタリング学会
    • Place of Presentation
      島津製作所イベントホール(東京)
    • Year and Date
      2012-07-14
    • Data Source
      KAKENHI-PROJECT-22591734
  • [Presentation] エリスポエチンの脳・脊髄保護効果2010

    • Author(s)
      松本美志也、吉村学、山下敦生、福田志朗、石田和慶
    • Organizer
      日本心臓血管麻酔学会第15回学術大会
    • Place of Presentation
      ザ・プリンスパークタワー東京東京
    • Year and Date
      2010-10-10
    • Data Source
      KAKENHI-PROJECT-21591974
  • [Presentation] Kazuyoshi Ishida Neuroprotective synergy of erythropoietin and insulin-like growth factor 1 in spinal cord ischemia2010

    • Author(s)
      Mishiya Matsumoto, Manabu Yoshimura, Atsuo Yamashita, Shiro Fukuda
    • Organizer
      American Society of Anesthesiologists Annual Meeting 2010
    • Place of Presentation
      米国San Diego
    • Year and Date
      2010-10-18
    • Data Source
      KAKENHI-PROJECT-21591974
  • [Presentation] 一過性脊髄虚血後の神経障害に対するerythropoietinとinsulin-like growth factor 1の保護効果2009

    • Author(s)
      吉村学、松本美志也、山下敦生、若松弘也、福田志朗、石田和慶、坂部武史
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸ポートピアホテル神戸
    • Year and Date
      2009-08-18
    • Data Source
      KAKENHI-PROJECT-21591974
  • [Presentation] 一過性脊髄虚血後の神経障害に対するerythropoietin とinsulin-like growth factor 1 の保護効果2009

    • Author(s)
      吉村学、松本美志也、山下敦生、若松弘也、福田志朗、石田和慶、坂部武史
    • Organizer
      第13回日本神経麻酔・集中治療研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-19591797
  • [Presentation] Neuroprotective synergy of erythropoietin and insulin-like growth factor 1 demonstrated in a spinal cord ischemia model in rabbits2008

    • Author(s)
      Mishiya Matsumoto, Manabu Yoshimura, Atsuo Yamashita, Hiroya Wakamatsu, Shiro Fukuda, kazuyoshi Ishida, Takefumi Sakabe
    • Organizer
      First congress of Asian society for neuroanesthesia and critical care
    • Place of Presentation
      中国北京
    • Year and Date
      2008-11-30
    • Data Source
      KAKENHI-PROJECT-19591797
  • 1.  MATSUMOTO Mishiya (60243664)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 18 results
  • 2.  ISHIDA Kazuyoshi (80314813)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 7 results
  • 3.  YAMASHITA Satoshi (20610885)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  FUKUDA Shiro (70322245)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 5.  WAKAMATSU Hiroya (80379966)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 6.  SAKABE Takeshi (40035225)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 7.  IIDA Yasuhiko (90304485)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  SAEKI Hiroshi (80379958)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  水上 洋一 (80274158)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  吉田 光剛 (60379972)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOSHIMURA Manabu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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