Ohta Hiroshi 大田浩

… Alternative Names

OHTA Hiroshi 大田浩

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Researcher Number	50391892
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都大学, 医学研究科, 准教授 2016 – 2018: 京都大学, 医学研究科, 助教 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Medium-sized Section 48:Biomedical structure and function and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related / Integrative animal science / Laboratory animal science / Laboratory animal science Except Principal Investigator Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Keywords	Principal Investigator 始原生殖細胞 / 培養 / 卵子形成 / ES細胞 / ヒト / 再構成卵巣 / 卵母細胞 / 卵原細胞 / 試験管内 / 細胞分化 … More / 細胞培養 / 分化 / 増殖 / 分化誘導 / 卵巣 / 原始卵胞 / 卵胞 / 卵子 / 支持細胞 / 体細胞 / 生殖巣 / マウス / PGCLC / 前顆粒膜細胞 / 雌性生殖巣体細胞 / in vitro / iPS細胞 / 胎生期生殖巣 / 始原生殖細胞様細胞 / 多能性幹細胞 / 試験管内誘導 / 細胞増殖 / 配偶子形成 / EpiLC / high-throughput screening / chemical libray / 精子形成 / 増殖・分化 / 小分子化合物 … More Except Principal Investigator 生殖細胞体外再構築 / ラット / マウス / 胚盤胞補完法 / アマミトゲネズミ / 生殖細胞 / 生殖巣 / iPS細胞 / 絶滅危惧種 / 性決定 Less

Establishment of an in vitro induction system from human oogonia to oocytes.Principal Investigator
- Principal Investigator
  
  大田浩
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Establish a culture system for somatic ovarian cells that can support in vitro oogenesisPrincipal Investigator
- Principal Investigator
  
  Ohta Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kyoto University
Elucidation of the gene expression cascade responsible for male sexuality and acquisition of fertility
- Principal Investigator
  
  本多新
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
- Research Institution
  Jichi Medical University
Establishment of culture system for inducing oocytes from primordial germ cell-like cellsPrincipal Investigator
- Principal Investigator
  
  Ohta Hiroshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
Establishment of efficient induction system for primordial germ cells from ES cells in vitroPrincipal Investigator
- Principal Investigator
  
  Ohta Hiroshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
Analysis of proliferation and differentiation of primordial germ cell-like cells derived from ES cellsPrincipal Investigator
- Principal Investigator
  
  Ohta Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Integrative animal science
- Research Institution
  Kyoto University
Establishment of novel technique using primordial germ cells induced from embryonic stem cellsPrincipal Investigator
- Principal Investigator
  
  OHTA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2018 2017 2013

All Journal Article Patent

[Journal Article] Generation of functional oocytes from male mice in vitro2023
- Author(s)
  Murakami Kenta、Hamazaki Nobuhiko、Hamada Norio、Nagamatsu Go、Okamoto Ikuhiro、Ohta Hiroshi、Nosaka Yoshiaki、Ishikura Yukiko、Kitajima Tomoya S.、Semba Yuichiro、Kunisaki Yuya、Arai Fumio、Akashi Koichi、Saitou Mitinori、Kato Kiyoko、Hayashi Katsuhiko
- Journal Title
  
  Nature
  
  Volume: 615 Issue: 7954 Pages: 900-906
- DOI
  10.1038/s41586-023-05834-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-21H02407, KAKENHI-PROJECT-20K21500, KAKENHI-ORGANIZER-18H05544, KAKENHI-PLANNED-18H05545, KAKENHI-PLANNED-18H05549, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-22K19604, KAKENHI-PROJECT-21H02950
[Journal Article] Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells2022
- Author(s)
  Ishikura Yukiko、Ohta Hiroshi、Nagano Masahiro、Saitou Mitinori
- Journal Title
  
  STAR Protocols
  
  Volume: 3 Issue: 3 Pages: 101544-101544
- DOI
  10.1016/j.xpro.2022.101544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-17H06098
[Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development2022
- Author(s)
  Nagano Masahiro, Hu Bo, Yokobayashi Shihori et al.
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 13
- DOI
  10.15252/embj.2022110600
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02613, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-21K20635, KAKENHI-PROJECT-23K23804, KAKENHI-PROJECT-21K20740, KAKENHI-PROJECT-17H06098
[Journal Article] <i>Ex vivo</i> reconstitution of fetal oocyte development in humans and cynomolgus monkeys2022
- Author(s)
  Mizuta Ken、Katou Yoshitaka、Nakakita Baku、Kishine Aoi、Nosaka Yoshiaki、Saito Saki、Iwatani Chizuru、Tsuchiya Hideaki、Kawamoto Ikuo、Nakaya Masataka、Tsukiyama Tomoyuki、Nagano Masahiro、Kojima Yoji、Nakamura Tomonori、Yabuta Yukihiro、Horie Akihito、Mandai Masaki、Ohta Hiroshi、Saitou Mitinori
- Journal Title
  
  The EMBO Journal
  
  Volume: 41 Issue: 18
- DOI
  10.15252/embj.2022110815
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06066, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-21K20740
[Journal Article] In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells2021
- Author(s)
  Ishikura Yukiko、Ohta Hiroshi、Sato Takuya、Murase Yusuke、Yabuta Yukihiro、Kojima Yoji、Yamashiro Chika、Nakamura Tomonori、Yamamoto Takuya、Ogawa Takehiko、Saitou Mitinori
- Journal Title
  
  Cell Stem Cell
  
  Volume: 28 Issue: 121 Pages: 2167-2179.e9
- DOI
  10.1016/j.stem.2021.08.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05546, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-20K21657, KAKENHI-PROJECT-17H06802, KAKENHI-PROJECT-23K20313
[Journal Article] The embryonic ontogeny of the gonadal somatic cells in mice and monkeys2021
- Author(s)
  Sasaki Kotaro、Oguchi Akiko、Cheng Keren、Murakawa Yasuhiro、Okamoto Ikuhiro、Ohta Hiroshi、Yabuta Yukihiro、Iwatani Chizuru、Tsuchiya Hideaki、Yamamoto Takuya、Seita Yasunari、Saitou Mitinori
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 5 Pages: 109075-109075
- DOI
  10.1016/j.celrep.2021.109075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21407, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-20KK0186
[Journal Article] Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†2020
- Author(s)
  Ohta Hiroshi、Yabuta Yukihiro、Kurimoto Kazuki、Nakamura Tomonori、Murase Yusuke、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Biology of Reproduction
  
  Volume: 104 Issue: 2 Pages: 344-360
- DOI
  10.1093/biolre/ioaa195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21500, KAKENHI-PLANNED-18H05553, KAKENHI-PROJECT-20H00471, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-18K19295, KAKENHI-PROJECT-17H06098, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714
[Journal Article] Long‐term expansion with germline potential of human primordial germ cell‐like cells in?vitro2020
- Author(s)
  Murase Yusuke、Yabuta Yukihiro、Ohta Hiroshi、Yamashiro Chika、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 21 Pages: 104929-104929
- DOI
  10.15252/embj.2020104929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21500, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-17H06098, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714
[Journal Article] Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys.2020
- Author(s)
  Sakai Y, Nakamura T, Okamoto I, Gyobu-Motani S, Ohta H, Yabuta Y, Tsukiyama T, Iwatani C, Tsuchiya H, Ema M, Morizane A, Takahashi J, Yamamoto T, Saitou M.
- Journal Title
  
  Biol Reprod
  
  Volume: 102(3) Issue: 3 Pages: 620-638
- DOI
  10.1093/biolre/ioz205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06030, KAKENHI-PROJECT-19K16013, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-18K14714, KAKENHI-PROJECT-17H06098
[Journal Article] ZGLP1 is a determinant for the oogenic fate in mice2020
- Author(s)
  Nagaoka So I.、Nakaki Fumio、Miyauchi Hidetaka、Nosaka Yoshiaki、Ohta Hiroshi、Yabuta Yukihiro、Kurimoto Kazuki、Hayashi Katsuhiko、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  Science
  
  Volume: 367 Issue: 6482 Pages: 4115-4115
- DOI
  10.1126/science.aaw4115
- NAID
  120006850276
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19295, KAKENHI-PLANNED-18H05553, KAKENHI-PROJECT-19H03618, KAKENHI-PROJECT-20K15801, KAKENHI-PROJECT-17H06098, KAKENHI-PLANNED-20H05761, KAKENHI-PROJECT-18K14714
[Journal Article] Induction of fetal primary oocytes and the meiotic prophase from mouse pluripotent stem cells.2018
- Author(s)
  Miyauchi H, Ohta H, Saitou M.
- Journal Title
  
  Methods Cell Biol.
  
  Volume: 144 Pages: 409-429
- DOI
  10.1016/bs.mcb.2018.03.035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05636, KAKENHI-PROJECT-17H06098
[Journal Article] Expansion of mouse primordial germ cell-like cells in culture reconstitutes an epigenetic blank slate.2017
- Author(s)
  Hiroshi Ohta, Kazuki Kurimoto, Ikuhiro Okamoto, Tomonori Nakamura, Yukihiro Yabuta, Hidetaka Miyauchi, Takuya Yamamoto, Yukiko Okuno, Masatoshi Hagiwara, Kenjiro Shirane, Hiroyuki Sasaki, Mitinori Saitou.
- Journal Title
  
  The EMBO Journal
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05636
[Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.2017
- Author(s)
  Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M
- Journal Title
  
  EMBO J
  
  Volume: 36 Issue: 13 Pages: 1888-1907
- DOI
  10.15252/embj.201695862
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01216, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112010, KAKENHI-PROJECT-16H04720, KAKENHI-PROJECT-15H05636, KAKENHI-PROJECT-21249013, KAKENHI-PROJECT-17H06098
[Journal Article] Fertile offspring from sterile sex chromosome trisomic mice2017
- Author(s)
  Hirota Takayuki、Ohta Hiroshi、Powell Benjamin E.、Mahadevaiah Shantha K.、Ojarikre Obah A.、Saitou Mitinori、Turner James M. A.
- Journal Title
  
  Science
  
  Volume: 357 Issue: 6354 Pages: 932-935
- DOI
  10.1126/science.aam9046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05636, KAKENHI-PROJECT-17H06098
[Journal Article] Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice2017
- Author(s)
  Miyauchi Hidetaka、Ohta Hiroshi、Nagaoka So、Nakaki Fumio、Sasaki Kotaro、Hayashi Katsuhiko、Yabuta Yukihiro、Nakamura Tomonori、Yamamoto Takuya、Saitou Mitinori
- Journal Title
  
  The EMBO Journal
  
  Volume: 36 Issue: 21 Pages: 3100-3119
- DOI
  10.15252/embj.201796875
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25114006, KAKENHI-PROJECT-15H05636, KAKENHI-PROJECT-16K14740, KAKENHI-INTERNATIONAL-15K21736, KAKENHI-PROJECT-17H01395, KAKENHI-PROJECT-17H06098
[Journal Article] Induction of mouse germ-cell fate by transcription factors in vitro.2013
- Author(s)
  Nakaki F, Hayashi K, Ohta H, Kurimoto K, Yabuta Y, Saitou M.
- Journal Title
  
  Nature
  
  Volume: 501 Issue: 7466 Pages: 222-226
- DOI
  10.1038/nature12417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03853, KAKENHI-PROJECT-21677003, KAKENHI-PROJECT-24680045, KAKENHI-PROJECT-24681039, KAKENHI-PROJECT-25290033, KAKENHI-PROJECT-25650065, KAKENHI-PROJECT-25650077
[Patent] 始原生殖細胞/始原生殖細胞様細胞の維持増幅及び分化誘導方法2023
- Inventor(s)
  斎藤通紀、大田浩、宮内英孝
- Industrial Property Rights Holder
  京都大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-24680045
[Patent] 始原生殖細胞/始原生殖細胞様細胞の維持増幅及び分化誘導方法2017
- Inventor(s)
  斎藤通紀、大田浩、宮内英孝
- Industrial Property Rights Holder
  京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-231294
- Filing Date
  2017-11-30
- Data Source
  KAKENHI-PROJECT-24680045

1. 本多新 (10373367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 磯谷綾子 (20444523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 的場章悟 (20585202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSUCHIYA Hideaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 小川毅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 栗本一基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 横林しほり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中家雅隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 林克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡本郁弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 村川泰裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohta Hiroshi 大田 浩

OHTA Hiroshi 大田 浩

Research Projects

Research Products

Co-Researchers

Establishment of an in vitro induction system from human oogonia to oocytes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establish a culture system for somatic ovarian cells that can support in vitro oogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the gene expression cascade responsible for male sexuality and acquisition of fertility

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of culture system for inducing oocytes from primordial germ cell-like cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of efficient induction system for primordial germ cells from ES cells in vitroPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of proliferation and differentiation of primordial germ cell-like cells derived from ES cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel technique using primordial germ cells induced from embryonic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of functional oocytes from male mice in vitro2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleome programming is required for the foundation of totipotency in mammalian germline development2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>Ex vivo</i> reconstitution of fetal oocyte development in humans and cynomolgus monkeys2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The embryonic ontogeny of the gonadal somatic cells in mice and monkeys2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†2020

Author(s)

Journal Title

Ohta Hiroshi 大田浩

OHTA Hiroshi 大田浩