Zako Tamotsu 座古保

… Alternative Names

ZAKO Tamotsu 座古保

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Researcher Number	50399440
Other IDs
Affiliation (Current)	2025: 愛媛大学, 理工学研究科(理学系), 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 愛媛大学, 理工学研究科(理学系), 教授 2015: 愛媛大学, 理工学研究科, 教授 2010 – 2014: 独立行政法人理化学研究所, 前田バイオ工学研究室, 専任研究員 2008: The Institute of Physical and Chemical Research, 前田バイオ工学研究室, 専任研究員 2007: The Institute of Physical and Chemical Research, 前田バイオ工学研究室, 研究員 2005 – 2006: 独立行政法人理化学研究所, 前田バイオ工学研究室, 研究員
Review Section/Research Field	Principal Investigator Basic Section 27040:Biofunction and bioprocess engineering-related / Structural biochemistry / Biophysics / Medium-sized Section 37:Biomolecular chemistry and related fields Except Principal Investigator Basic Section 34020:Analytical chemistry-related / Basic Section 14030:Applied plasma science-related / Basic Section 43030:Functional biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Internal medicine of the bio-information integration and related fields / Plasma electronics / Applied pharmacology / Nanomaterials chemistry / Nanomaterials/Nanobioscience
Keywords	Principal Investigator プレフォルディン / 一分子計測 / 高感度検出 / 金ナノ粒子 / アミロイド / 暗視野顕微鏡 / アミロイド凝集 / アルツハイマー病 / タンパク質ミスフォールディング病 / 分子シャペロンタンパク質 … More / リフォールディング / 分子間相互作用 / シャペロニン / 分子シャペロン / 好熱菌タンパク質 / スペクトルイメージング / 単一クラスター解析 / ナノ粒子 / 生体化合物 / 内分泌撹乱性 / トランスサイレチン / 内分泌撹乱性評価 / １分子計測 / 暗視野イメージング / 高感度分子検出 / バイオ分析 / 暗視野観察 / 散乱光 / スモールヒートショックプロテイン / 一分子蛍光イメージング / タンパク質凝集 / アミロイドβ / 細胞毒性 / 可溶性オリゴマー / ミスフォールディングタンパク質凝集 / アップコンバージョンナノ粒子 / 変性タンパク質 / 蛍光偏光異方性解消法 / 1分子イメージング … More Except Principal Investigator タンパク質 / 過硝酸 / 大気圧プラズマ / プラズマ医療 / 酵素 / 電気泳動法 / 殺菌 / アミノ酸 / プラズマ誘起液中化学反応場 / 活性窒素種 / プラズマ誘起液中化学反応 / プラズマ殺菌 / 自己組織化 / DNA / プラズマバイオ / 生体高分子反応 / 機能と構造 / 糖鎖修飾 / オスモライト / 深共晶溶媒 / インフラマソーム / 液-液相分離 / 液液層分離 / インタラクトーム / ASC-speck / 分離分析法 / 天然超分子 / 酵素活性 / 天然酵素 / タンパク質複合体 / 機能制御 / 非変性 / 分離と溶出 / 電気泳動 / 超分子 / 活性窒素酸素種 / 反応速度論 / プラズマ消毒 / 難病 / コンパニオン診断 / インフラマソーム病 / 細胞内酸化ストレス / 化学反応速度 / 低温プラズマ / 活性酸素 / 液中プラズマプロセス / 人工細胞 / リポソーム / 酸化ストレス / プラズマ処理水 / シャペロン / ラジカル解離 / 液中プラズマ / 毒性 / 構造 / 予後 / MRI / 病態 / アミロイドーシス / インスリン / 一次元配列構造 / 1次元配列構造 / フレンケル励起子 / 量子ドット / メタマテリアル Less

酵素の本来の活性を引き出す天然溶媒の設計
- Principal Investigator
  
  白木賢太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  University of Tsukuba
タンパク質の機能・構造とその糖鎖修飾の状態との関係を分析する新規電気泳動法の構築
- Principal Investigator
  
  島崎洋次
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Ehime University
スペクトルイメージングを駆使した超高感度・構造多型評価可能な多元的バイオ分析Principal Investigator
- Principal Investigator
  
  座古保
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Ehime University
アミロイド凝集を指標とした生体化合物の内分泌撹乱性評価法の創出Principal Investigator
- Principal Investigator
  
  座古保
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Ehime University
Establish of aberrant liquid-liquid phase separation disease and identification of causative target molecules
- Principal Investigator
  
  Masumoto Junya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Ehime University
Role of chemical modifications to biomolecules in plasma bioprocessing
- Principal Investigator
  
  北野勝久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 14030:Applied plasma science-related
- Research Institution
  Osaka University
Construction of high resolution separation analysis and function control methods for natural supramolecules
- Principal Investigator
  
  島崎洋次
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Ehime University
Sensitive molecular sensing using single molecule analysis of target-induced gold nanoparticle aggregationPrincipal Investigator
- Principal Investigator
  
  Zako Tamotsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Ehime University
Deepening of plasma induced chemical reaction in liquid considering RNS and its distribution in liquid
- Principal Investigator
  
  KITANO Katsuhisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 14030:Applied plasma science-related
- Research Institution
  Osaka University
Acceleration of the definition of "inflammasome disease" based on molecular mechanism of diseases
- Principal Investigator
  
  MASUMOTO Junya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Internal medicine of the bio-information integration and related fields
- Research Institution
  Ehime University
Pathophysiology and developing mechanism, and structure and toxicity of insulin-derived amyloidosis
- Principal Investigator
  
  Terumasa Nagase
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo Medical University
Understanding the plasma biological interaction based on intracellular oxidative stress
- Principal Investigator
  
  Kitano Katsuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Plasma electronics
- Research Institution
  Osaka University
Synthesis and Characterization of Closely-Spaced Ultrasmall Quantum Dot Chains Towards Artificial Frenkel-type Exciton Formation
- Principal Investigator
  
  Oda Masaru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nanomaterials chemistry
- Research Institution
  Kyushu Institute of Technology
Role of molecular chaperone protein in aggregation of misfolded proteinsPrincipal Investigator
- Principal Investigator
  
  ZAKO TAMOTSU
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Ehime University
  The Institute of Physical and Chemical Research
Fabrication of metamaterials working in visible region by using DNA self-organization
- Principal Investigator
  
  TAKEYASU Nobuyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Osaka University
Effect of molecular chaperone on misfolding protein aggregationPrincipal Investigator
- Principal Investigator
  
  ZAKO Tamotsu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Molecular mechanism of chaperone networkPrincipal Investigator
- Principal Investigator
  
  ZAKO Tamotsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research
シャペロンダイナミクスの1分子イメージングPrincipal Investigator
- Principal Investigator
  
  座古保
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Heat shock proteins : New Research Chapter XXI2008
- Author(s)
  Zako, T.
- Total Pages
  23
- Publisher
  Nova Science Publishers Inc., New York, USA
- Data Source
  KAKENHI-PROJECT-19770137
[Book] "Chaperonin and prefoldin - Two molecular chaperones that work cooperatively in archaea and eukaryote" (Invited Review) in Heat shock proteins : New Research (Edited by Emma Moreland and Camille Vincent)2008
- Author(s)
  Zako, T., Iizuka, R., Kanzaki, T., Maeda, M. and Yohda, M.
- Publisher
  Nova Science Publishers, Inc., New York, USA
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Polyallylamine Binds to Aβ Amyloid and Inhibits Antibody Recognition2024
- Author(s)
  Tsuchie Yusuke、Kusuda Soichiro、Kawabe Haruka、Mori Wakako、Lindgren Mikael、Watanabe Yutaka、Zako Tamotsu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 6 Pages: 3112-3112
- DOI
  10.3390/ijms25063112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19114, KAKENHI-PROJECT-23K26471
[Journal Article] Peroxynitric acid inhibits amyloid b aggregation2023
- Author(s)
  Haruka Kawabe, Satoshi Ikawa, Katsuhisa Kitano, Tamotsu Zako
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 660 Pages: 1-5
- DOI
  10.1016/j.bbrc.2023.03.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19114, KAKENHI-PROJECT-23K22482, KAKENHI-PROJECT-23K26471
[Journal Article] Analysis of the enzymatic degradation of lysozyme fibrils using a combination method of non-denaturing gel electrophoresis and double staining with Coomassie brilliant blue G-250 and R-250 dyes2023
- Author(s)
  Kenichiro Nagata, Ryo Ashikaga, Wakako Mori, Tamotsu Zako, Youji Shimazaki
- Journal Title
  
  Analytical Sciences
  
  Volume: 39 Pages: 267-274
- DOI
  10.1007/s44211-022-00229-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05128, KAKENHI-PROJECT-22K19114, KAKENHI-PROJECT-19H02527
[Journal Article] Effect of DNA density immobilized on gold nanoparticles on nucleic acid detection2023
- Author(s)
  Hirao Gen、Fukuzumi Nanami、Ogawa Atsushi、Asahi Tsuyoshi、Mizuo Maeda、Zako Tamotsu
- Journal Title
  
  RSC Advances
  
  Volume: 13 Issue: 44 Pages: 30690-30695
- DOI
  10.1039/d3ra06528f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19114, KAKENHI-PROJECT-23K26471
[Journal Article] Inflammasome assembly is required for intracellular formation of β2-microglobulin amyloid fibrils, leading to IL-1β secretion2022
- Author(s)
  Kaneko Naoe、Mori Wakako、Kurata Mie、Yamamoto Toshihiro、Zako Tamotsu、Masumoto Junya
- Journal Title
  
  International Journal of Immunopathology and Pharmacology
  
  Volume: 36 Pages: 039463202211045-039463202211045
- DOI
  10.1177/03946320221104554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19438, KAKENHI-PROJECT-20H03719, KAKENHI-PROJECT-22H04356, KAKENHI-PROJECT-19H02527
[Journal Article] Differences in interaction lead to the formation of different types of insulin amyloid2022
- Author(s)
  Mori Wakako、Kawakami Ryosuke、Niko Yosuke、Haruta Tomohiro、Imamura Takeshi、Shiraki Kentaro、Zako Tamotsu
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 8556-8556
- DOI
  10.1038/s41598-022-12212-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H03056, KAKENHI-PROJECT-19H02527
[Journal Article] Recent advances in research on biointerfaces: From cell surfaces to artificial interfaces2022
- Author(s)
  Hori Katsutoshi、Yoshimoto Shogo、Yoshino Tomoko、Zako Tamotsu、Hirao Gen、Fujita Satoshi、Nakamura Chikashi、Yamagishi Ayana、Kamiya Noriho
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 133 Issue: 3 Pages: 195-207
- DOI
  10.1016/j.jbiosc.2021.12.004
- NAID
  210000159547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00841, KAKENHI-PROJECT-19H02527
[Journal Article] Colorimetric detection of thrombin based on signal amplification by transcription-reverse transcription concerted reaction using non-crosslinking aggregation of gold nanoparticles2022
- Author(s)
  Yu Muto and Tamotsu Zako
- Journal Title
  
  Analytical Sciences
  
  Volume: 38 Issue: 1 Pages: 3-7
- DOI
  10.1007/s44211-022-00050-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] DNA密生金ナノ粒子で分子を検出！――環境中の微量なホルモン分子の簡易検出法へ道を拓く2022
- Author(s)
  平尾元、座古保
- Journal Title
  
  化学
  
  Volume: 77 Pages: 47-51
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] Inhibition of amyloid formation of amyloid β(1-42), amylin and insulin by 1,5-diazacyclooctanes, as spermine-acrolein conjugate2021
- Author(s)
  R. Kunitomi, A. R. Pradipta, H. Kawabe, N. Lobsiger, K. Tanaka, T. Zako
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 46 Pages: 116391-116391
- DOI
  10.1016/j.bmc.2021.116391
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H02527
[Journal Article] Protein-Functionalized Gold Nanoparticles for Antibody Detection Using the Darkfield Microscopic Observation of Nanoparticle Aggregation2021
- Author(s)
  YOSHIMURA Ken、PATMAWATI、MAEDA Mizuo、KAMIYA Noriho、ZAKO Tamotsu
- Journal Title
  
  Anal. Sci.
  
  Volume: 37 Issue: 3 Pages: 507-511
- DOI
  10.2116/analsci.20SCP12
- NAID
  130007996243
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2021-03-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] Insulin amyloid fibrils interact directly with the NLRP3, resulting in inflammasome activation and pyroptotic cell death2021
- Author(s)
  Wakako Mori, Naoe Kaneko, Ayaka Nakanishi, Tamotsu Zako and Junya Masumoto
- Journal Title
  
  International Journal of Immunopathology and Pharmacology
  
  Volume: 35 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] Transcription-Based Amplified Colorimetric Thrombin Sensor Using Non-Crosslinking Aggregation of DNA-Modified Gold Nanoparticles2021
- Author(s)
  Yu Muto, Gen Hirao and Tamotsu Zako
- Journal Title
  
  Sensors
  
  Volume: 21 Issue: 13 Pages: 4318-4318
- DOI
  10.3390/s21134318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] 金ナノ粒子を用いるカロリメトリックバイオセンサー2021
- Author(s)
  武藤悠、座古保
- Journal Title
  
  分析化学
  
  Volume: 70 Pages: 661-670
- NAID
  130008162185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation2021
- Author(s)
  Yano-Ozawa Yuki、Lobsiger Nadine、Muto Yu、Mori Takahiro、Yoshimura Ken、Yano Yuki、Stark Wendelin Jan、Maeda Mizuo、Asahi Tsuyoshi、Ogawa Atsushi、Zako Tamotsu
- Journal Title
  
  RSC Advances
  
  Volume: 11 Issue: 20 Pages: 11984-11991
- DOI
  10.1039/d0ra05149g
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02527, KAKENHI-PROJECT-19K05697
[Journal Article] Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates2021
- Author(s)
  Mori Wakako、Yuzu Keisuke、Lobsiger Nadine、Nishioka Hideo、Sato Hisako、Nagase Terumasa、Iwaya Keiichi、Lindgren Mikael、Zako Tamotsu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 6857-6857
- DOI
  10.1038/s41598-021-86001-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08708, KAKENHI-PROJECT-19H02527
[Journal Article] Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity2020
- Author(s)
  Keisuke Yuzu, Mikael Lindgren, Sofie Nystrom, Jun Zhang, Wakako Mori, Risako Kunitomi, Terumasa Nagase, Keiichi Iwaya, Per Hammarstrom, Tamotsu Zako
- Journal Title
  
  RSC Adv
  
  Volume: 10 Issue: 62 Pages: 37721-37727
- DOI
  10.1039/d0ra07742a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08708, KAKENHI-PROJECT-19H02527
[Journal Article] Detection of Gold Nanoparticles Aggregation Using Light Scattering for Molecular Sensing2019
- Author(s)
  Yuki Yano, Masamichi Nisougi, Yuki Yano-Ozawa, Tsuyoshi Ohguni, Atsushi Ogawa, Mizuo Maeda, Tsuyoshi Asahi, Tamotsu Zako
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 6 Pages: 685-690
- DOI
  10.2116/analsci.18P571
- NAID
  130007661696
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-06-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05846, KAKENHI-PROJECT-19H02527
[Journal Article] Toxicity of insulin-derived amyloidosis: a case report2019
- Author(s)
  Iwaya K., Zako T., Fukunaga J., Sorgjerd KM., Ogata K., Kogure K, Kosano H., Noritake M., Maeda M., Ando Y., Katsura Y., Nagase T.
- Journal Title
  
  BMC Endocr Disord
  
  Volume: 26 Issue: 1 Pages: 61-61
- DOI
  10.1186/s12902-019-0385-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03565, KAKENHI-PROJECT-19H02527
[Journal Article] Analysis of the degradation of amyloid beta fibrils after separation via the combination of non‐denaturing agarose electrophoresis and Congo red dye staining2019
- Author(s)
  Kawano Risa、Nakanishi Ayaka、Zako Tamotsu、Shimazaki Youji
- Journal Title
  
  SEPARATION SCIENCE PLUS
  
  Volume: 2 Issue: 9 Pages: 322-328
- DOI
  10.1002/sscp.201900049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02527
[Journal Article] Insulin-derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases2019
- Author(s)
  Nagase T., Iwaya K., Kogure K., Zako T., Misumi Y., Kikuchi M., Matsumoto K., Noritake M., Kawachi Y., Kobayashi M., Ando Y., Katsura Y.
- Journal Title
  
  J Diabetes Investig
  
  Volume: - Issue: 4 Pages: 1002-1005
- DOI
  10.1111/jdi.13199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03565, KAKENHI-PROJECT-17K08708, KAKENHI-PROJECT-19H02527
[Journal Article] Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion2019
- Author(s)
  Yovita Djohan, Tomoki Azukizawa, Patmawati, Kotaro Sakai, Yuki Yano, Fumiya Sato, Ryoji Takahashi, Masafumi Yohda, Mizuo Maeda, Noriho Kamiya and Tamotsu Zako*
- Journal Title
  
  Biomaterials Science
  
  Volume: 7 Issue: 5 Pages: 1801-1804
- DOI
  10.1039/c8bm01026a
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K04705, KAKENHI-PROJECT-16H04572, KAKENHI-PUBLICLY-18H04690, KAKENHI-PROJECT-19H02527
[Journal Article] Construction of Quenchbodies to detect and image amyloid β oligomers2018
- Author(s)
  Dong Jinhua、Fujita Richi、Zako Tamotsu、Ueda Hiroshi
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 550 Pages: 61-67
- DOI
  10.1016/j.ab.2018.04.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08597, KAKENHI-PROJECT-18H03851
[Journal Article] Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system2018
- Author(s)
  Nakanishi Ayaka、Kaneko Naoe、Takeda Hiroyuki、Sawasaki Tatsuya、Morikawa Shinnosuke、Zhou Wei、Kurata Mie、Yamamoto Toshihiro、Akbar Sheikh Mohammad Fazle、Zako Tamotsu、Masumoto Junya
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 38 Issue: 1 Pages: 27-27
- DOI
  10.1186/s41232-018-0085-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-17H04656, KAKENHI-PROJECT-17K19685, KAKENHI-PROJECT-18H00464, KAKENHI-PLANNED-16H06579
[Journal Article] IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation2018
- Author(s)
  Morikawa S, Kaneko N, Okumura C, Taguchi H, Kurata M, Yamamoto T, Osawa H, Nakanishi A, Zako T, Masumoto J.
- Journal Title
  
  International Journal of Immunopathology and Pharmacology
  
  Volume: 32 Pages: 205873841878874-205873841878874
- DOI
  10.1177/2058738418788749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04656, KAKENHI-PROJECT-17K19685, KAKENHI-PROJECT-18H00464
[Journal Article] Dark Field Microscopic Sensitive Detection of Amyloid Fibrils Using Gold Nanoparticles Modified with Antibody2016
- Author(s)
  Tong Bu, Tamotsu Zako他
- Journal Title
  
  Anal. Sci.
  
  Volume: 32 Issue: 3 Pages: 307-311
- DOI
  10.2116/analsci.32.307
- NAID
  130005131631
- ISSN
  0910-6340, 1348-2246
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24570143, KAKENHI-PROJECT-25286015
[Journal Article] Contribution of the C-Terminal Region of a Group II Chaperonin to its Interaction with Prefoldin and Substrate Transfer.2016
- Author(s)
  Zako T, Sahlan M, Fujii S, Yamamoto YY, Tai PT, Sakai K, Maeda M, Yohda M.
- Journal Title
  
  J Mol Biol.
  
  Volume: 印刷中 Issue: 11 Pages: 2405-2417
- DOI
  10.1016/j.jmb.2016.04.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102511, KAKENHI-PROJECT-24570143, KAKENHI-PUBLICLY-16H00753, KAKENHI-PROJECT-16H04572
[Journal Article] Adsorption and separation of amyloid beta aggregates using ferromagnetic nanoparticles coated with charged polymer brushes2015
- Author(s)
  Tong Bu, Tamotsu Zako他
- Journal Title
  
  Journal of Materials Chemistry B
  
  Volume: 3 Issue: 16 Pages: 3351-3357
- DOI
  10.1039/c4tb02029d
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570143
[Journal Article] Cysteine inhibits the fibrillisation and cytotoxicity of amyloid-β 40 and 42 : implications for the contribution of the thiophilic interaction2014
- Author(s)
  Eisuke Takai, Ken Uda, Tomonori Yoshida, Tamotsu Zako, Mizuo Maeda, Kentaro Shiraki
- Journal Title
  
  Physical Chemistry Chemical Physics
  
  Volume: 16 Issue: 8 Pages: 3566-3572
- DOI
  10.1039/c3cp54245a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00669, KAKENHI-PROJECT-23246063, KAKENHI-PROJECT-23550189, KAKENHI-PROJECT-24570143
[Journal Article] Degeneration of amyloid-β fibrils by low temperature atmospheric pressure plasma in solution2014
- Author(s)
  Eisuke Takai, Gai Ohashi, Tomonori Yoshida, Karin Margareta Sorgjerd, Tamotsu Zako, Mizuo Maeda, Katsuhisa Kitano, Kentaro Shiraki
- Journal Title
  
  Applied Physics Letters
  
  Volume: 104 Issue: 2 Pages: 23701-23701
- DOI
  10.1063/1.4861842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00669, KAKENHI-PROJECT-23340176, KAKENHI-PROJECT-23550189, KAKENHI-PROJECT-24570143, KAKENHI-PUBLICLY-25108505
[Journal Article] Application of biomaterials for the detection of amyloid aggregates2014
- Author(s)
  Tamotsu Zako他
- Journal Title
  
  Biomaterials Science
  
  Volume: 2 Issue: 7 Pages: 951-955
- DOI
  10.1039/c4bm00026a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570143
[Journal Article] Cysteine inhibit amyloid fibril formation and direct to amorphous aggregation of lysozyme by non-covalent interactions2014
- Author(s)
  Eisuke Takai, Ken Uda, Shuhei Matsushita, Yui Shikiya, Yoichi Yamada, Zako Tamotsu, Mizuo Maeda, Kentaro Shiraki
- Journal Title
  
  Biotechnology Progress
  
  Volume: (印刷中) Issue: 2 Pages: 470-478
- DOI
  10.1002/btpr.1866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00669, KAKENHI-PROJECT-24570143
[Journal Article] Rapid Surface- Biostructure Interaction Analysis using strong Metal-based Nanomagnets2013
- Author(s)
  Aline C.C. Rotzetter, Tamotsu Zako他
- Journal Title
  
  Langmuir
  
  Volume: 29 Issue: 46 Pages: 14117-14123
- DOI
  10.1021/la4026427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570143
[Journal Article] A structure-toxicity study of Abeta42 reveals a new anti-parallel aggregation pathway2013
- Author(s)
  Helene Vignaud, Tamotsu Zako他
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e80262-e80262
- DOI
  10.1371/journal.pone.0080262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570143
[Journal Article] Human prefoldin inhibits Aβfibrillation and contributes to formation of non-toxic Aβaggregates2013
- Author(s)
  K.M. Sörgjerd, T. Zako, M. Sakono, P.C. Stirling, M.R. Leroux, T. Saito, P. Nilsson, M. Sekimoto, T.C.Saido, M. Maeda
- Journal Title
  
  Biochemistry
  
  Volume: 52 Issue: 20 Pages: 3532-3542
- DOI
  10.1021/bi301705c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680039, KAKENHI-PROJECT-23760758, KAKENHI-PROJECT-24570143
[Journal Article] Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation.2013
- Author(s)
  Tashiro E, Zako T, Muto H, Itoo Y, Sorgjerd K, Terada N, Abe A, Miyazawa M, Kitamura A, Kitaura H, Kubota H, Maeda M, Momoi T, Iguchi-Ariga SM, Kinjo M, Ariga H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 27 Pages: 19958-19972
- DOI
  10.1074/jbc.m113.477984
- NAID
  120005323603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570220, KAKENHI-PROJECT-23770215, KAKENHI-PROJECT-24570143, KAKENHI-PROJECT-24651223
[Journal Article] Cell interaction study of amyloid using luminescent conjugated polythiophene : Implication that amyloid cytotoxicity is correlated with prolonged cellular binding2012
- Author(s)
  Tamotsu Zako
- Journal Title
  
  ChemBioChem
  
  Volume: (in press) Issue: 3 Pages: 358-363
- DOI
  10.1002/cbic.201100467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117, KAKENHI-PROJECT-23760758
[Journal Article] Application of two morphologically different fibrillar and filamentous insulin amyloids as a biomaterial for cell culture surfaces2011
- Author(s)
  Sakono M, Akiyama S, Zako T., Sakaki S, Waku T, Tanaka N, Maeda M
- Journal Title
  
  React. Funct. Polymer
  
  Volume: 71 Pages: 324-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Immobilized Insulin Amyloid Enhances Cell Adhesion and Proliferation due to Interaction with Fibronectin2011
- Author(s)
  Sakono M, Akiyama S, Zako T., Sakaki S, Waku T, Tanaka N, Maeda M
- Journal Title
  
  Chem. Lett
  
  Volume: 40 Pages: 315-317
- NAID
  10027815991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Analysis of interaction mode between hyperthermophilic archaeal group II chaperonin and prefoldin using a platform of chaperonin oligomers of various subunit arrangements2010
- Author(s)
  Sahlan M., Kanzaki T., Zako T., Maeda M. and Yohda M.
- Journal Title
  
  Biochimica et Biophysica Acta-Proteins and Proteomics
  
  Volume: 1804 Pages: 1810-1816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] A facile method towards cyclic assembly of gold nanoparticles using DNA template alone2010
- Author(s)
  T. Ohshiro, T. Zako, R. Watanabe-Tamaki, T. Tanaka, M. Maeda
- Journal Title
  
  Chem. Commun
  
  Volume: 46 Pages: 6132-6132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651045
[Journal Article] Size-selective recognition of gold nanoparticles by a molecular chaperone2010
- Author(s)
  Sakono M, Zako T., Drakulic S, Valpuesta J. M, Yohda M and Maeda M
- Journal Title
  
  Chem. Phys. Lett
  
  Volume: 501 Pages: 108-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Hyperthermophilic archaeal prefoldin shows refolding activity at low temperature2010
- Author(s)
  Tamotsu Zako
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 391 Pages: 467-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Amyloid oligomers : Formation and toxicity of Abeta oligomers2010
- Author(s)
  Sakono M. and Zako T.
- Journal Title
  
  FEBS J.
  
  Volume: 277 Pages: 1348-1358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Thermodynamic Characterization of the Interaction between Prefoldin and Group II Chaperonin2010
- Author(s)
  Sahlan M., Zako T., Tai Phan The, Ohtaki A., Noguchi K., Maeda M., Miyatake H., Dohmane N. and Yohda M.
- Journal Title
  
  J. Mol. Biol
  
  Volume: 399 Pages: 628-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] A facile method towards cyclic assembly of gold nanoparticles using DNA template alone2010
- Author(s)
  T.Ohshiro, T.Zako, R.Watanabe-Tamaki, T.Tanaka, M.Maeda
- Journal Title
  
  Chemical Communications
  
  Volume: 46 Pages: 6132-6134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651045
[Journal Article] Bio-Supramolecular Photochirogenesis with Molecular Chaperone : Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Prefoldin2010
- Author(s)
  Bando K., Zako T., Sakono M., Maeda M., Wada T., Nishijima M., Fukuhara G., Yang C., Mori T., Pace TCS., Bohne C. and Inoue Y.
- Journal Title
  
  Photochem. & Photobiol. Sci
  
  Volume: 9 Pages: 655-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Amyloid oligomers2010
- Author(s)
  Tamotsu Zako
- Journal Title
  
  FEBS Journal
  
  Volume: 277 Pages: 1347-1347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Hyperthermophilic archaeal prefoldin shows refolding activity at low temperature2010
- Author(s)
  Zako T., Banba S., Sahlan M., Sakono M., Terada N., Yohda M. and Maeda M.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 391 Pages: 467-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770117
[Journal Article] Dynamics of group II chaperonin and prefoldin probed by 13C NMR spectroscopy2008
- Author(s)
  Kurimoto, E., Nishi, Y., Yamaguchi, Y., Zako, T., Iizuka, R., Ide, N., Yohda, M. and Kato, K.
- Journal Title
  
  Proteins 70
  
  Pages: 1257-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Effect of the C-terminal truncation on the functional cycle of chaperonin groel : Implication that the C-terminal region facilitates the transition from the folding-arrested to the folding-competent state.2008
- Author(s)
  Suzuki M, Ueno T, Iizuka R, Miura T, Zako T, Akahori R, Miyake T, Shimamoto N, Aoki M, Tanii T, Ohdomari I, Funatsu T.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 23931-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe2008
- Author(s)
  Zako, T., Nagata, H., Terada, N., Sakono, M, Soga, K and Maeda, M.
- Journal Title
  
  J. Materials Sci. 43
  
  Pages: 5325-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Improvement of dispersion stability and characterization of upcbnversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe2008
- Author(s)
  Zako, T.
- Journal Title
  
  Journal of Materials Science 43
  
  Pages: 5325-5330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Kinetic Analysis of Conformational Changes of GroEL Based on the Fluorescence of Tyrosine 506.2008
- Author(s)
  Hosono K, Ueno T, Taguchi H, Motojima F, Zako T, Yoshida M, Funatsu T.
- Journal Title
  
  Protein J. 27
  
  Pages: 461-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Complex formation of CdSe/ZnS/TOPO nanocrystal vs. molecular chaperone in aqueous solution by hydrophobic interaction2007
- Author(s)
  Horiuchi, H., Iwami, N., Tachibana, F., Ohtaki, A., Iizuka, R., Zako, T., Oda, M., Yohda, M. and Tani, T.
- Journal Title
  
  J. Luminescence 127
  
  Pages: 192-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Selectivity improvement in protein nanopatterning with a hydroxy-terminated self-assembled monolayer template2007
- Author(s)
  Miyake, T, Tanii, T., Kato, K., Zako, T., Funatsu, T. and Ohdomari I.
- Journal Title
  
  Nanotechnology 18
  
  Pages: 305304-305304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Journal Article] Localization of Prefoldin Interaction Sites in the Hyperthermophilic Group II Chaperonin and Correlations between Binding Rate and Protein Transfer Rate2006
- Author(s)
  Zako, T.
- Journal Title
  
  Journal of Molecular Biology 364
  
  Pages: 110-120
- Data Source
  KAKENHI-PROJECT-17770134
[Journal Article] Facilitated release of substrate protein from prefoldin by chaperonin2005
- Author(s)
  Zako T.
- Journal Title
  
  FEBS Letters 579
  
  Pages: 3718-3724
- Data Source
  KAKENHI-PROJECT-17770134
[Journal Article] Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin
- Author(s)
  Sakono, M., Zako, T., Ueda, H., Yohda, M. and Maeda, M.
- Journal Title
  
  FEBS Journal (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770137
[Patent] 分子の検出方法2020
- Inventor(s)
  座古保、武藤悠
- Industrial Property Rights Holder
  愛媛大学、東ソー株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] バイオ分子凝集を用いた新規分析手法2024
- Author(s)
  座古保
- Organizer
  九州大学未来化学創造センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] Sensitive Biosensing Using Gold Nanoparticles"2024
- Author(s)
  Tamotsu Zako
- Organizer
  11TH KYOTO INTERNATIONAL FORUM FOR ENVIRONMENT AND ENERGY
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] バイオ分子凝集を用いた新規分析手法2024
- Author(s)
  座古保
- Organizer
  九州大学未来化学創造センターセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] インスリンアミロイド凝集体に対する過硝酸(PNA)の影響2024
- Author(s)
  村上唯人、渡辺嵩大、土江祐介、井川聡、北野勝久、座古保
- Organizer
  2024 Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] 金ナノ粒子凝集の光化学的観察手法を用いたバイオセンシング2024
- Author(s)
  座古保
- Organizer
  先端分析化学研究セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] アミロイド凝集の構造多型制御及びキラル化合物による影響評価2024
- Author(s)
  渡辺嵩大、土江祐介、佐藤久子、座古保
- Organizer
  2024 Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] 金ナノ粒子凝集の高感度検出のための簡易・安価な光散乱比色分析装置の開発2023
- Author(s)
  朝日剛、鎌田留理子、近藤亘、座古保、福住奈那実
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] アミロイド凝集を指標とした化合物の内分泌撹乱性評価法の創出2023
- Author(s)
  座古保、福永隼大、国末達也
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] タンパク質のアミロイド凝集にまつわるエトセトラ2023
- Author(s)
  座古保
- Organizer
  14th Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 核酸アプタマー修飾金ナノ粒子を用いた炎症バイオマーカータンパク質の検出2023
- Author(s)
  福住奈那実、中川貴鼓、平尾元、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] インスリンアナログ製剤のアミロイド形成に重要な相互作用の解明2023
- Author(s)
  土江祐介、森若子、永瀬晃正、菊地実、岩屋啓一、Mikael Lindgren、Per Hammarstrom、白木賢太郎、座古保
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] 暗視野顕微鏡による金ナノ粒子1粒子観察を利用するデジタルイムノアッセイ2023
- Author(s)
  平尾元、武藤悠、朝日剛、前田瑞夫、座古保
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] インスリンアミロイド形成における相分離現象および構造・毒性相関2023
- Author(s)
  座古保
- Organizer
  第二回相分離生物物理学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] タンパク質のナノ分析研究2023
- Author(s)
  座古保
- Organizer
  生物化学工学シンポジウム2023
- Invited
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 異種金属ナノ粒子複合体由来の輝点解析による生体分子検出法の開発2023
- Author(s)
  平尾元・小川敦司・朝日剛・前田瑞夫・田中拓男・横田秀夫・座古保
- Organizer
  14th Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] DNA固定化金ナノ粒子表面へのアルカンチオール修飾による架橋型凝集に基づく標的分子検出への影響2023
- Author(s)
  田中優稀、福住奈那実、平尾元、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] 核酸アプタマー修飾異種金属ナノ粒子の架橋による混合色輝点形成を用いた生体分子検出2023
- Author(s)
  平尾元、小川敦司、朝日剛、前田瑞夫、田中拓男、横田秀夫、座古保
- Organizer
  第83回分析化学討論会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] インスリンアナログのアミロイド形成における重要な相互作用の差異2023
- Author(s)
  土江祐介、森若子、永瀬晃正、菊池実、岩谷啓一、 Mikael Lindgren 、 Per Hammarström 、白木賢太郎、座古保
- Organizer
  14th Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] キラル化合物が構造多型を有するアミロイド凝集に及ぼす影響2023
- Author(s)
  渡辺嵩大、土江祐介、佐藤久子、座古保
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] DNA固定化金ナノ粒子表面へのアルカンチオール修飾による分散安定性及び標的分子検出感度への影響：塩基配列依存性評価を中心に2023
- Author(s)
  福住奈那実、平尾元、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  第83回分析化学討論会
- Data Source
  KAKENHI-PROJECT-23K26471
[Presentation] 金ナノ粒子を用いたバイオセンシング2022
- Author(s)
  座古保
- Organizer
  生物化学的測定研究会第27回学術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] DNA固定化金ナノ粒子を用いた核酸検出における DNA密度の検出感度への影響2022
- Author(s)
  平尾元、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  第82回分析討論会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] インスリンアミロイド形成における相分離現象および構造・毒性相関2022
- Author(s)
  座古保
- Organizer
  第二回相分離生物物理学研究会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] DNA固定化金ナノ粒子の表面修飾による分散安定性と標的分子検出感度への影響2022
- Author(s)
  福住奈那実、平尾元、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  日本分析化学会第71年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] DNA固定化金ナノ粒子の DNA構造による核酸検出感度への影響2022
- Author(s)
  平尾元、福住奈那実、朝日剛、前田瑞夫、小川敦司、座古保
- Organizer
  日本分析化学会第71年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] タンパク質のアミロイド凝2022
- Author(s)
  座古保
- Organizer
  14th Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] インスリン製剤由来のアミロイド形成に重要な相互作用2022
- Author(s)
  土江祐介、森若子、 Mikael Lindgren 、Per Hammarstrom 、岩屋啓一、永瀬晃正、座古保
- Organizer
  第22回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 金ナノ粒子を用いたバイオセンシング2022
- Author(s)
  座古保
- Organizer
  生物化学的測定研究会第27回学術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] 先端ナノ・バイオ分析研究の進展について2022
- Author(s)
  座古保
- Organizer
  ナノ・プラズマバイオ研究会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] インスリン製剤由来のアミロイド形成に重要な相互作用2022
- Author(s)
  土江祐介、森若子、 Mikael Lindgren 、Per Hammarstrom 、岩屋啓一、永瀬晃正、座古保
- Organizer
  第22回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-22K19114
[Presentation] β2ミクログロブリンのアミロイド線維形成にはインフラマソームの形成が必須である2022
- Author(s)
  金子直恵、森若子、倉田美恵、山本敏弘、座古保、増本純也
- Organizer
  第45回日本分子生物学会年会(千葉)2022/11/30-12/2
- Data Source
  KAKENHI-PROJECT-22K19438
[Presentation] Degradation of human insulin amyloid by minocycline2021
- Author(s)
  Wakako Mori, Keisuke Yuzu, Keiichi Iwaya, Terumasa Nagase, Nadine Obsiger, Mikael LIndgren, Sofie Nystrom, Per Hammarstrom and Tamots Zako
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 金ナノ粒子凝集を用いた高感度分子検出2021
- Author(s)
  座古保
- Organizer
  日本化学会岡山地区化学講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Molecular detection using dark field imaging of functionalized nanoparticles2021
- Author(s)
  Tamotsu Zako
- Organizer
  Pacifichem2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] インスリンアミロイドとNLRP3の直接的相互作用によるインフラマソーム活性化とハイプロトーシス2021
- Author(s)
  森若子、金子直恵、中西文香、座古保、増本純也
- Organizer
  第44回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] DDNA固定化ナノ粒子を用いた核酸検出へ向けたナノ粒子及びDNA固定化条件の検討2021
- Author(s)
  平尾元・矢野湧暉・小川敦司・前田瑞夫・朝日剛・座古保
- Organizer
  日本分析化学会第70年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] ミノサイクリンによるインスリンアミロイド分解生成物の構造・毒性評価2021
- Author(s)
  森若子・柚佳祐・Nadine Lobsiger・佐藤久子・永瀬晃正・岩屋啓一・Mikael Lindgren・座古保
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Inhibition of aggregation of Amyloid β protein by peroxynitric acid2021
- Author(s)
  Haruka Kawabe, Katsuhisa Kitano, Satoshi Ikawa and Tamostu Zako
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 過硝酸によるアミロイドβタンパク質の凝集および細胞毒性抑制2021
- Author(s)
  川邊春花・井川聡・北野勝久・座古保
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 過硝酸によるアミロイドβタンパク質の凝集抑制2020
- Author(s)
  川邊春花・井川聡・北野勝久・座古保
- Organizer
  2020日本化学会中国四国支部大会島根大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Haruka Kawabe, Sotoshi Ikawa, Katsuhisa Kitano and Tamotsu Zako "Effect Of Peroxynitric Acid On Aggregation Of Amyloid β Protein2020
- Author(s)
  Wakako Mori, Keisuke Yuzu, Keiichi Iwaya, Terumasa Nagase, Nadine Lobsiger, Mikael Lindgren, Sofie Nystrom, Peter Nilsson, Per Hammastrom and Tamotsu Zako
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Effect of peroxynitric acid on aggregation of Amyloid β protein2020
- Author(s)
  川邊春花, 井川聡, 北野勝久, 座古保
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H01205
[Presentation] 過硝酸によるアミロイドβタンパク質の凝集抑制2020
- Author(s)
  川邊春花, 井川聡, 北野勝久, 座古保
- Organizer
  日本化学会中国四国支部大会
- Data Source
  KAKENHI-PROJECT-18H01205
[Presentation] 異なる2種の金属ナノ粒子の架橋による混合色輝点の形成を利用した抗体検出2020
- Author(s)
  吉村健、矢野湧暉、Wahyudin Patmawati、神谷典穂、武藤悠、朝日剛、前田瑞夫、座古保
- Organizer
  日本分析化学会第69年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] インスリンアミロイドに対する抗生物質ミノサイクリンの影響評価2020
- Author(s)
  森若子・柚佳祐・Nadine Lobsiger・永瀬晃正・岩屋啓一・Mikael Lindgren・座古保
- Organizer
  2020日本化学会中国四国支部大会島根大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] プラズマ誘起液中化学反応場における生体高分子の化学修飾2020
- Author(s)
  北野勝久, 井川聡, 横山高史, 座古保, 白木賢太郎
- Organizer
  第81回応用物理学会秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18H01205
[Presentation] 高機能化ナノ粒子を用いたバイオ分析2020
- Author(s)
  座古保
- Organizer
  生物工学Webシンポジウム2020
- Invited
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] タンパク質修飾金ナノ粒子の合成および凝集体の暗視野顕微鏡観察による抗体分子検出2020
- Author(s)
  吉村健・Wahyudin Patmawati・神谷典穂・前田瑞夫・座古保
- Organizer
  2020日本化学会中国四国支部大会島根大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Effect Of Peroxynitric Acid On Aggregation Of Amyloid β Protein2020
- Author(s)
  Haruka Kawabe, Sotoshi Ikawa, Katsuhisa Kitano and Tamotsu Zako
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 2種の核酸アプタマー修飾ナノ粒子の架橋による混合色輝点の形成を利用したトロンビン検出2020
- Author(s)
  吉村健、矢野湧暉、矢野雄暉、小川敦司、前田瑞夫、朝日剛、齋藤伸吾、吉本敬太郎、座古保
- Organizer
  第80回分析化学討論会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] アミロイドβタンパク質の凝集に対する過硝酸の影響評価2020
- Author(s)
  川邊春花、井川聡、北野勝久、座古保
- Organizer
  2020 Biomedical Interface Workshop
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 固定化DNAを介して核酸アプタマーを就職した金ナノ粒子によるトロンビンタンパク質の検出2019
- Author(s)
  吉村健、矢野湧暉、矢野雄暉、小川敦司、前田瑞夫、古性均、斎藤伸吾、吉本敬太郎、座古保
- Organizer
  第７８回分析討論会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 分子シャペロンプレフォルディンの新規な活性2019
- Author(s)
  座古保
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] ポリアミン由来８員環化合物を用いたヘパリンによるアミロイド凝集促進効果の抑制2019
- Author(s)
  國富理紗子、 Ambara RachmatPradipta、田中克典、座古保
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] ヘパリンによるアミロイド凝集促進効果に対するポリアミン由来８員環化合物の影響評価2019
- Author(s)
  國富理紗子、Pradipta Ambara R、田中克典、座古保
- Organizer
  第71回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 塩添加による金ナノ粒子凝集過程の実時間観測2019
- Author(s)
  冨永康樹、座古保、朝日剛
- Organizer
  第７８回分析討論会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 異なる2種のナノ粒子の架橋による混合色輝点の形成を利用したトロンビン検出2019
- Author(s)
  吉村健、矢野湧暉、矢野雄暉、小川敦司、前田瑞夫、朝日剛、齋藤伸吾、吉本敬太郎、座古保
- Organizer
  日本分析化学会第68回年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 固定化DNAを介した核酸アプタマー修飾金ナノ粒子を用いた選択的分子検出2019
- Author(s)
  矢野雄暉、矢野湧暉、小川敦司、朝日剛、前田瑞夫、座古保
- Organizer
  第７８回分析討論会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 非変性条件アガロースゲル電気泳動法とコンゴーレッドによるアミロイドβ凝集体の分離分析法の構築2019
- Author(s)
  島崎洋次、川野莉沙、足利諒、座古保
- Organizer
  日本プロテオーム学会2019年大会・第70回日本電気泳動学会総会合同大会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 種々色素とネイティブ電気泳動法の組み合わせによるタンパク質及びタンパク質凝集体のネイティブ分離分析法の検討2019
- Author(s)
  島崎洋次、井上蒼士、足利諒、座古保
- Organizer
  日本分析化学会第68回年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] 高密度固定化DNAを介した核酸アプタマー修飾金ナノ粒子を用いた夾雑試料中からの分子検出2019
- Author(s)
  矢野雄暉、矢野湧暉、小川敦司、前田瑞夫、朝日剛、座古保
- Organizer
  日本分析化学会第68回年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Sensitive detection of biomolecules with functionalized nanoparticles2019
- Author(s)
  Tamotsu Zako
- Organizer
  YABEC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] オリゴチオフェン系新規蛍光プローブを用いたインスリンアミロイド凝集の評価2019
- Author(s)
  柚佳祐、Mikael Lindgren、Sofie Nystrom、Jun Zhang、Per Hammarstrom、Peter Nilsson、國富理紗子、岩屋啓一、永瀬晃正、座古保
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19H02527
[Presentation] Clinical and MRI characteristics and follow-up studies of insulin-derived amyloidosis2018
- Author(s)
  Terumasa Nagase, Keiichi Iwaya, Tamotsu Zako, Tomotada Odaka, Kouichiro Kogure, Yoko Nemoto, Yohei Misumi, Masayuki Noritake, Yukio Ando, Yoshiya Katsura
- Organizer
  The XVIth International Symposium on Amyloidosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] アミロイドAβの重合化は試験管内無細胞インフラマソームの形成を促進する2018
- Author(s)
  金子直恵、中西文香、座古保、増本純也.
- Organizer
  第39回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-17K19685
[Presentation] Aβのアミロイド凝集体によるNLRP3インフラマソームの活性化2018
- Author(s)
  中西文香、金子直恵、座古保、増本純也.
- Organizer
  第41回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19685
[Presentation] 腫瘤を触知しないインスリン由来アミロイドーシスの臨床的影響と画像2018
- Author(s)
  永瀬晃正、岩屋啓一、座古保、小高以直、小暮晃一郎、三井雅子、根本洋子、則武昌之、桂善也
- Organizer
  第61日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] インスリンボールの毒性と構造及びミノサイクリンによる影響の調査2017
- Author(s)
  福永隼大、永瀬晃正、岩屋啓一、座古保
- Organizer
  第17回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2017-06-21
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] インスリン由来アミロイドーシス（インスリンボール）の臨床的影響と長期予後2017
- Author(s)
  永瀬晃正、小高以直、柿崎雄介、岩城祥樹、三井雅子、根本洋子、則武昌之、座古保、岩屋啓一、桂善也
- Organizer
  第60回日本糖尿病学会年次学術集会
- Place of Presentation
  名古屋
- Year and Date
  2017-05-18
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] インスリンボールの超微形態2017
- Author(s)
  岩屋啓一、永瀬晃正、座古　保、伊藤喜之、桂　善也
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2017-04-29
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] ナノ粒子を用いた高感度生体分子検出2016
- Author(s)
  座古　保
- Organizer
  第３回ISITナノ・バイオフォーラム
- Place of Presentation
  福岡市産学連携交流センター（福岡県）
- Year and Date
  2016-02-15
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] ナノ粒子を用いた生体分析化学2016
- Author(s)
  座古　保
- Organizer
  第13回プラスモニクスシンポジウム
- Place of Presentation
  愛媛大学（愛媛県）
- Year and Date
  2016-01-22
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] インスリン由来アミロイドーシス（インスリンボール）の細胞毒性とアミロイド構造2016
- Author(s)
  永瀬晃正、岩屋啓一、座古保、内田龍志、小高以直、岩城祥樹、三井雅子、根本洋子、則武昌之、桂善也
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] Nanoparticles for sensitive bio-detection and bioimaging2016
- Author(s)
  Tamotsu Zako
- Organizer
  2016 International Biomedical Interface Symposium
- Place of Presentation
  台北医学大（台湾）
- Year and Date
  2016-03-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] インスリン由来アミロイドーシス（インスリンボール）は血糖コントロール悪化及びインスリン量増加の原因となる2016
- Author(s)
  永瀬晃正、岩屋啓一、岩城祥樹、小高以直、柿崎雄介、根本洋子、則武昌之、座古保、桂善也
- Organizer
  第4回アミロイドーシス研究会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-15K08597
[Presentation] DNAを用いた量子ドット1次元配列構造の作製とその分離・精製法の開発2016
- Author(s)
  西輝，赤木啓人，早川賢治，松尾公祐，小田勝，座古保，前田瑞夫，谷俊朗
- Organizer
  ナノ学会第14回大会
- Place of Presentation
  北九州国際会議場
- Year and Date
  2016-06-14
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] 金ナノ粒子凝集を利用した、タンパク質アミロイド凝集体の高感度検出2015
- Author(s)
  座古　保他
- Organizer
  第75回分析化学討論会
- Place of Presentation
  山梨大学（山梨県）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] Self-Assembled Quantum-Dot Chains Linked by DNA: Synthesis, Characterization and Optical Properties2015
- Author(s)
  Masaru Oda, Hiroto Akagi, Kousuke Matsuo, Tamotsu Zako, Mizuo Maeda, Sachio Naemura, Takahiro Mukasa, Toshiro Tani
- Organizer
  12th International Conference on Hole Burning, Single Molecule and Related Spectroscopies: Science and Applications
- Place of Presentation
  Tartu, Estnia
- Year and Date
  2015-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] Nanoparticle engineering for sensitive bio-detection and bioimaging2015
- Author(s)
  Tamotsu Zako
- Organizer
  International Sympoisum of KSBB
- Place of Presentation
  Seoul（韓国）
- Year and Date
  2015-10-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 金ナノ粒子凝集を利用した、単一クラスター観察によるタンパク質アミロイド凝集体の高感度検出2015
- Author(s)
  座古　保他
- Organizer
  日本分析化学会第64年会
- Place of Presentation
  九州大学（福岡県）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] DNAを利用した一次元量子ドット配列構造の合成とその物性評価2015
- Author(s)
  赤木啓人，松尾公祐，小田勝，座古保，前田瑞夫，谷俊朗
- Organizer
  第76回応用物理学会秋季学術講演会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] Ultrasensitive detection of biomolecules using aggregation of functionalized gold nanoparticles2015
- Author(s)
  Tamotsu Zako他
- Organizer
  Pacifichem2015
- Place of Presentation
  ホノルル（USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] Biomolecule detection using functionalized nanoparticles2015
- Author(s)
  Tamotsu Zako
- Organizer
  The 21th Symposium of Young Asian Biochemical Engineers’Community
- Place of Presentation
  春川（韓国）
- Year and Date
  2015-10-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] DNA を利用した一次元量子ドット配列構造の作製とその光物性2015
- Author(s)
  松尾公祐，赤木啓人，小田勝，座古保，前田瑞夫，谷俊朗
- Organizer
  第121回日本物理学会九州支部例会
- Place of Presentation
  九州工業大学
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] 産業応用にむけた分子シャペロンタンパク質の機能探索2015
- Author(s)
  座古　保
- Organizer
  第67回日本生物工学会
- Place of Presentation
  城山観光ホテル（鹿児島県）
- Year and Date
  2015-10-28
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] プレフォルディンとの協調作用におけるグループII型シャペロニンC末端の機能解明2014
- Author(s)
  座古保他
- Organizer
  GE Life Sience Day
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-08-01
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] プレフォルディンとの協調作用におけるグループII型シャペロニンC末端の機能解明2014
- Author(s)
  座古保他
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（神奈川県横浜市）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 抗体担持金ナノ粒子を用いた高感度アミロイドベータ凝集検出2014
- Author(s)
  Tong Bu,座古保他
- Organizer
  第66会日本生物工学会年会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 分子シャペロンタンパク質の新機能探索2014
- Author(s)
  座古保
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（神奈川県横浜市）
- Year and Date
  2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] Synthesis and PL properties of one-dimensional chains composed of colloidal CdSe/ZnS QDs linked by DNA2013
- Author(s)
  Masaru Oda, Sachio Naemura, Takahiro Mukasa, Tamotsu Zako, Mizuo Maeda, and Toshiro Tani
- Organizer
  18th International Conference on Dynamical Processes in Excited States of Solids (DPC’13)
- Place of Presentation
  Fuzhou (China)
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] オリゴDNAを利用した一次元量子ドット近距離配列構造の作製とその光学特性2013
- Author(s)
  小田勝，苗村祥央，武笠峻大，座古保，前田瑞夫，谷俊朗
- Organizer
  日本物理学会2013年秋季大会
- Place of Presentation
  徳島大学（徳島）
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] Function and application of protein molecules and bio-nanoparticles2011
- Author(s)
  Tamotsu Zako and Mizuo Maeda
- Organizer
  Japan-Canada Nanotechnology Workshop
- Place of Presentation
  Toronto, Canada
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Development of new photon counting histogram method towards precise analysis of oligomerization2011
- Author(s)
  Naofumi Terada, Tamotsu Zako, Masafumi Sakono and Mizuo Maeda
- Organizer
  第49回生物物理年会
- Place of Presentation
  姫路
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Noodle'-like filaments of bovine insulin and ss2 microglobulin were non-cytotoxic due to abbreviated cell binding2011
- Author(s)
  Tamotsu Zako
- Organizer
  EMBO meeting
- Place of Presentation
  Vienna, Austria
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Noodle'-like filaments of bovine insulin andβ2 microglobulin were non-cytotoxic due to abbreviated cell binding2011
- Author(s)
  Tamotsu Zako, Masafumi Sakono, Takahiro Kobayashi, K. Peter R. Nilsson, Per Hammarstrom, Mikael Lindgren and Mizuo Maeda
- Organizer
  EMBO meeting 2011
- Place of Presentation
  Vienna
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] 近赤外光を用いたバイオイメージングのためのナノ粒子開発とその応用2011
- Author(s)
  座古保
- Organizer
  第63回日本生物工学会大会
- Place of Presentation
  東京農工大学(東京)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Formation of non-toxic Abeta amyloids by small heat shock protein(sHsp) under stress condition2010
- Author(s)
  Tamotsu Zako, Masafumi Sakono, Arata Utsum, Chika Sugino, Masafumi Yohda, Mizuo Maeda
- Organizer
  EMBO meeting
- Place of Presentation
  Barcelona Spain
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Formation of non-toxic Abeta fibrils by small heat shock protein (sHsp) under stress condition2010
- Author(s)
  Tamotsu Zako
- Organizer
  Cold Spring Harbor Meeting Molecular Chaperons & Stress responses
- Place of Presentation
  New York, USA
- Year and Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Amyloid Beta Oligomer Studied By photon counting histogram2010
- Author(s)
  Naofumi Terada, Tamotsu Zako, Masafumi Sakono and Mizuo Maeda
- Organizer
  第48回日本生物物理学会
- Place of Presentation
  仙台
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Supramolecular photochirogenesis with biomolecular hosts2010
- Author(s)
  Y. Inoue, M. Nishijima, C. Yang, T. Mori, T. Wada, K. Bando, T. Zako, M. Sakon, M. Maeda, T. Pace, C. Bohne
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] ポリグルタミンタンパク質凝集における分子シャペロンプレフォルディンの役割2010
- Author(s)
  伊藤禎宣、座古保、Karin Sorgjerd、寺田尚史、田代絵梨佳、北村朗、久保田広志、武藤秀樹、金城政孝、有賀寛芳、前田瑞夫
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Formation of non-toxic Abeta amyloids by small heat shock protein (sHsp) under stress condition2010
- Author(s)
  Tamotsu Zako
- Organizer
  EMBO meeting
- Place of Presentation
  Barcelona Spain
- Year and Date
  2010-09-06
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Molecular chaperone prefoldin blocks the formation of mutant Huntingtin oligomer and inclusion body, resulting in reduction of its cytotoxity2010
- Author(s)
  Erika Tashiro, Hideki Muto, Tamotsu Zako, Makoto Miyazawa, Hirotake Kitaura, Akira Kitamura, Hiroshi Kubota, Mizuo Maeda, Masataka Kinjo, Hiroyoshi Ariga
- Organizer
  Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] 分子シャペロンPrefoldinは変異ハンチンチンのオリゴマーおよび凝集体形成を阻害して細胞死を減少させる2010
- Author(s)
  田代絵梨佳,武藤秀樹,座古保,宮澤誠,北浦廣剛,北村朗,久保田広志,前田瑞夫,金城政孝,有賀寛芳
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] The Molecular Chaperone Prefoldin can Capture Aggregation Prone States of A-Beta and Might Play a Role in the Progress of Alzheimer's Disease2010
- Author(s)
  Karin Sorgjerd, Tamotsu Zako, Masafumi Sakono, Peter Stirling, Michel Leroux, Mizuo Maeda
- Organizer
  第59回高分子学会年次大会
- Place of Presentation
  仙台
- Year and Date
  2010-05-24
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] 分子シャペロンをめぐる分子間相互作用の解析2010
- Author(s)
  養王田正文、阿部哲也、Sahlan Muhamad, Phan The tai,神埼太郎、岡俊彦、座古保、前田瑞夫
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] The molecular chaperone prefoldin can capture aggregation prone states of A-beta and might play a role in the progress of Alzheimers disease2010
- Author(s)
  Karin Sorgjerd, Tamotsu Zako, Masafumi Sakono, Peter Stirling, Michel Leroux, Mizuo Maeda
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Formation of non-toxic Abeta fibrils by small heat shock protein(sHsp) under stress condition2010
- Author(s)
  Tamotsu Zako, Masafumi Sakono, Arata Utsum, Chika Sugino, Masafumi Yohda, Mizuo Maeda
- Organizer
  Cold Spring Harbor Meeting Molecular Chaperons & Stress responses
- Place of Presentation
  New York, USA
- Year and Date
  2010-05-07
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Toxic amyloid oligomer detection system using molecular chaperone2010
- Author(s)
  Masafumi Sakono, Tamotsu Zako, Masafumi Yohda and Mizuo Maeda
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-22770117
[Presentation] Development of PEGylated upconversion nanophosphors as a fluorescence bioimaging probe and its application for tumor cell imaging2008
- Author(s)
  Zako, T.
- Organizer
  YABEC2008
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Detection and diagnostics of amyloidic proteins using luminescent conjugated polymers2008
- Author(s)
  Mikael Lindgren, Tamotsu Zako, Mizuo Maeda, Per Hammarstrom and K. Peter R. Nilsson
- Organizer
  Joint Meeting of the Japanese Biochemical Society and the Molecular Biology Society of Japan
- Place of Presentation
  Kobe
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Small heat shock protein (sHsp)はストレス条件下においてアミロイドβと複合化し無毒のアミロイド様繊維を生成する2008
- Author(s)
  座古保、迫野昌文、内海現太、養王田正文、前田瑞夫
- Organizer
  第3回臨床ストレス応答学会
- Place of Presentation
  秋田
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Prefoldin prudentially interacts with group II chaperonin in its ADP bound open conformation2008
- Author(s)
  Tamotsu Zako, Yosuke Murase, Ryo Iizuka, Taro Kanzaki, Masafumi Shimizu, Masafumi Yohda and Mizuo Maeda
- Organizer
  33^<rd> FEBS congress and 11^<th> IUBMB conference
- Place of Presentation
  Athens, Greece
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Small heat shock protein (sHsp)はストレス条件下においてアミロイド6と複合化し無毒のアミロイド様繊維を生成する2008
- Author(s)
  座古保
- Organizer
  第3回臨床ストレス応答学会
- Place of Presentation
  秋田
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Detection and diagnostics of amyloidic proteins using luminescent conjugated polymers2008
- Author(s)
  Zako, T.
- Organizer
  Joint Meeting of the Japanese Biochemical Society and the Molecular Biology Society of Japan
- Place of Presentation
  Kobe, Japan
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Formation of Novel Non-toxic Insulin Amyloid Filaments by reducing agent2008
- Author(s)
  Tamotsu Zako, Masafumi Sakono, Naomi Hashimoto, Masaki Ihara and Mizuo Maeda
- Organizer
  8^<th> World Biomaterial Congress
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Development of PEGylated upconversion nanophosphors as a fluorescence bioimaging probe and its application for tumor cell imaging2008
- Author(s)
  Tamotsu Zako, Hiroyasu Nagata, Naofumi Terada, Arata Utsumi, Masafumi Sakono, Hiroshi Ueda, Masafumi Yohda, Kohei Soga and Mizuo Maeda
- Organizer
  YABEC2008
- Place of Presentation
  Tokyo
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] 分子シャペロンによる新規なアミロイド形成2008
- Author(s)
  座古保、迫野昌文、内海現太、養王田正文、前田瑞夫
- Organizer
  化学工学会沖縄大会
- Place of Presentation
  沖縄
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin2008
- Author(s)
  Masafumi Sakono, Tamotsu Zako, Hiroshi Ueda, Masafumi Yohda and Mizuo Maeda
- Organizer
  Cold Spring Harbor Meeting Molecular Chaperons & Stress responses
- Place of Presentation
  New York, USA
- Year and Date
  2008-05-05
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] プレフォルディンーシャペロニンの相互作用解析による基質受け渡し機構の解明2007
- Author(s)
  座古保
- Organizer
  蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Interaction of prefoldin with group II chaperonin in the presence of various nucleotides2007
- Author(s)
  Tamotsu Zako
- Organizer
  2nd World conference of Stress
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2007-08-25
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] プレフォルディン-シャペロニンの相互作用解析による基質受け渡し機構の解明2007
- Author(s)
  座古保, 村瀬陽介, 清水雅史, 飯塚怜, 前田瑞夫, 養王田正文
- Organizer
  蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Interaction of prefoldin with group II chaperonin in the presence of various nucleotides2007
- Author(s)
  Tamotsu Zako, Yosuke Murase, Andrei Zhukov, Robert Karlsson, Masafumi Shimizu, Ryo Iizuka, Mizuo Maeda, and Masafumi Yohda
- Organizer
  2^<nd> World conference of Stress
- Place of Presentation
  Budapest, Hunagry
- Year and Date
  2007-08-25
- Data Source
  KAKENHI-PROJECT-19770137
[Presentation] Formation of protein aggregates and their toxicity
- Author(s)
  Tamotsu Zako
- Organizer
  KIFIEE 2014 Meeting
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] Chaperone engineering - New bio-functions of molecular chaperone protein
- Author(s)
  Tamotsu Zako
- Organizer
  KIFEE 2012
- Place of Presentation
  Tronheim (Norway)
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 分子シャペロンタンパク質の機構解明と機能探索
- Author(s)
  座古　保
- Organizer
  九州大学未来化学創造センターナノバイオアセンブリワークショップ
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 分子シャペロンタンパク質の新しい機能探索
- Author(s)
  座古　保
- Organizer
  第64回生物工学会年会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] 分子シャペロンsHsp（small heat shock protein）の会合状態のアミロイドβ凝集への影響
- Author(s)
  吉田知識, 座古保　他
- Organizer
  第６５回日本生物工学会年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24570143
[Presentation] コロイド状半導体量子ドットによる一次元配列構造の作製とその光学評価
- Author(s)
  小田勝，松尾公祐，赤木啓人,苗村祥央,武笠峻大,谷俊朗,座古保,前田瑞夫
- Organizer
  応用物理学会九州支部学術講演会
- Place of Presentation
  大分大学(旦野原キャンパス)
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-25286015
[Presentation] 分子シャペロンsHspの会合状態のアミロイドβ凝集への影響
- Author(s)
  吉田知識, 座古保他
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-24570143

1. 白木賢太郎 (90334797)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. Kitano Katsuhisa (20379118)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. MASUMOTO Junya (20334914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 朝日剛 (20243165)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 島崎洋次 (80284389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. TAKEYASU Nobuyuki (90373323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TANAKA Takuo (40283733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Oda Masaru (30345334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. Terumasa Nagase (10408114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. KATSURA YOSHIYA (90266487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. Tani Atsushi (10335333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Ikawa Satoshi (80393297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岩屋啓一 (50312012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
14. 大澤春彦 (90294800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小川敦司 (30442940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
16. 国末達也 (90380287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 平野篤 (90613547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 横田秀夫 (00261206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. Kaneko naoe

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. KITAMURA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 安東由喜雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. PRADIPTA AMBARA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 今村健志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 神谷典穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 斉藤貴志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 澤崎達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 金城政孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 久保田広志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 養王田正文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 高橋亮治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 佐藤文哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Zako Tamotsu 座古 保

ZAKO Tamotsu 座古 保

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スペクトルイメージングを駆使した超高感度・構造多型評価可能な多元的バイオ分析Principal Investigator

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アミロイド凝集を指標とした生体化合物の内分泌撹乱性評価法の創出Principal Investigator

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Sensitive molecular sensing using single molecule analysis of target-induced gold nanoparticle aggregationPrincipal Investigator

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Role of molecular chaperone protein in aggregation of misfolded proteinsPrincipal Investigator

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Zako Tamotsu 座古保

ZAKO Tamotsu 座古保