Matsumoto GEN 松本弦

… Alternative Names

MATSUMOTO Gen 松本弦

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Researcher Number	50415303
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 准教授 2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Affiliation (based on the past Project Information) *help	2024: 大阪公立大学, 大学院医学研究科, 准教授 2015 – 2024: 長崎大学, 医歯薬学総合研究科(医学系), 講師 2014: 独立行政法人理化学研究所, 脳科学総合研究センター, 客員研究員 2014: 独立行政法人理化学研究所, 視床発生研究チーム, 研究員 2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2008 – 2012: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員
Review Section/Research Field	Principal Investigator Biological Sciences / Nerve anatomy/Neuropathology / Basic Section 51030:Pathophysiologic neuroscience-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Complex systems / Biological Sciences
Keywords	Principal Investigator 選択的オートファジー / p62 / SQSTM1 / アグリファジー / 神経変性疾患 / タンパク質分解 / アグリソーム / オートファジー / タウ / p62/SQSTM1 … More / タウオパチー / p62/sqstm1 / リン酸化 / ポリユビキチン / アグリファジー促進 / 凝集体分解 / p６２ / 認知症治療薬 / タウタンパク質分解 / タウアミロイド / 脳神経疾患 / タンパク質凝集 / タンパク質凝集体 / アシルドーパミン / 神経老化 / マイトファジー / 薬剤ライブラリー / レポーターアッセイ / レポーター / 薬剤スクリーニング / オートファゴソーム / ユビキチン / シクエストソーム / プロテアソーム / ライブセルイメージング / ビメンチン / NES / 核外移行 / ハンチンチン / FRET / 核外移行シグナル / ハンチントン病 / 神経変成疾患 … More Except Principal Investigator 認知症 / 凝集体 / 神経変性疾患 / α-シヌクレイン / リゾリン脂質 / パーキンソン病 / プローブ / シンギュラリティ生物学 / イメージング / ゲノム編集 / タンパク質凝集 / プローブ開発 / １分子イメージング / 脳神経疾患 / アルツハイマー病 / 光遺伝学 / タウ / シンギュラリティ / ネットワーク / 蛍光タンパク質 / 細胞特異性 / 神経変性 / 遺伝子発現 / 有棘神経細胞 / 線条体 / beta4 subunit / sodium channel / 無髄線維 / セルソーター / NF-Y / p62 / FUS/TLS / 大脳基底核 / ポリグルタミン病 Less

Novel aggrephagy pathway for Tau amyloid degradationPrincipal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Regulatory Mechanisms of Aggrephagy that Promote Degradation of Tau AggregatesPrincipal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka Metropolitan University
  Nagasaki University
Elucidation of alpha-synuclein aggregation inhibition mechanism by lysophospholipids and development of drug discovery for neurodegenerative diseases
- Principal Investigator
  
  塚原完
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nagasaki University
molecular mechanism of p62/SQSTM1-mediated aggrephagyPrincipal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Research on the molecular mechanism of singularity phenomenon in neurological disorders
- Principal Investigator
  
  Bannai Hiroko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Waseda University
Regulation mechanism of the selective autophagy though p62/SQSTM1 expressionPrincipal Investigator
- Principal Investigator
  
  MATSUMOTO Gen
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
老化神経細胞モデルによる神経変性疾患発症機構の解析Principal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
ストレス条件下における選択的オートファジーの制御機構Principal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Regulatory mechanism of p62 gene expressionPrincipal Investigator
- Principal Investigator
  
  MATSUMOTO Gen
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
The development and analysis of selective neuronal pathology
- Principal Investigator
  
  NUKINA Nobuyuki
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
  The Institute of Physical and Chemical Research
Molecular mechanism underlying selective autophagy of aggregated proteinPrincipal Investigator
- Principal Investigator
  
  MATSUMOTO Gen
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research
ストレス条件下における異常タンパク質隔離の分子機構Principal Investigator
- Principal Investigator
  
  松本弦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Molecular mechanism behind the nuclear export of huntingtin protiensPrincipal Investigator
- Principal Investigator
  
  MATSUMOTO Gen
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research

[Journal Article] 認知症治療薬開発と線維化タウモデル2023
- Author(s)
  松本　弦
- Journal Title
  
  コスモ・バイオニュース
  
  Volume: 198 Pages: 1-4
- Open Access
- Data Source
  KAKENHI-PROJECT-23K24214
[Journal Article] 認知症治療薬開発と線維化タウモデル2023
- Author(s)
  松本弦
- Journal Title
  
  コスモ・バイオニュース
  
  Volume: 198 Pages: 1-4
- Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04651
[Journal Article] Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.2023
- Author(s)
  Ayami Okuzumi Taku Hatano Gen Matsumoto Nobutaka Hattori et al
- Journal Title
  
  Nature medicine
  
  Volume: 29 Issue: 6 Pages: 1448-1455
- DOI
  10.1038/s41591-023-02358-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14785, KAKENHI-PROJECT-21K07283, KAKENHI-PROJECT-21K07424, KAKENHI-PROJECT-21K07444, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-21H04820, KAKENHI-PROJECT-23K24214
[Journal Article] The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis2023
- Author(s)
  Hatanaka Atsushi、Nakada Sota、Matsumoto Gen、Satoh Katsuya、Aketa Iori、Watanabe Akira、Hirakawa Tomoaki、Tsujita Tadayuki、Waku Tsuyoshi、Kobayashi Akira
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 14405-14405
- DOI
  10.1038/s41598-023-41492-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07417, KAKENHI-PUBLICLY-22H04651, KAKENHI-PUBLICLY-22H04659, KAKENHI-PROJECT-23K24214, KAKENHI-PROJECT-23K24772, KAKENHI-PROJECT-23K28007
[Journal Article] Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022
- Author(s)
  Ono Maiko、Komatsu Masaaki、Ji Bin、Takado Yuhei、Shimojo Masafumi、Minamihisamatsu Takeharu、Warabi Eiji、Yanagawa Toru、Matsumoto Gen、Aoki Ichio、Kanaan Nicholas M.、Suhara Tetsuya、Sahara Naruhiko、Higuchi Makoto
- Journal Title
  
  Aging Cell
  
  Volume: 21 Issue: 7
- DOI
  10.1111/acel.13615
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07580, KAKENHI-PROJECT-22K07529, KAKENHI-PUBLICLY-21H05705, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PLANNED-18H05414, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PUBLICLY-21H00446, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-23K24214
[Journal Article] Detection of Prions in a Cadaver for Anatomical Practice2022
- Author(s)
  Nakagaki Takehiro、Kaneko Miho、Satoh Katsuya、Murai Kiyohito、Saiki Kazunobu、Matsumoto Gen、Ogami-Takamura Keiko、Ikematsu Kazuya、Akagi Akio、Iwasaki Yasushi、Tsurumoto Toshiyuki、Nishida Noriyuki
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 386 Issue: 23 Pages: 2245-2246
- DOI
  10.1056/nejmc2204116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07276, KAKENHI-PROJECT-21K07417, KAKENHI-PROJECT-20K16183, KAKENHI-PLANNED-18H05414, KAKENHI-PUBLICLY-22H04651, KAKENHI-PROJECT-23K21396, KAKENHI-PROJECT-23K24214
[Journal Article] A central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy2022
- Author(s)
  Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M. Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
- Journal Title
  
  Aging Cell
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Journal Article] SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells2022
- Author(s)
  Kawase Naoyuki、Sugihara Atsuya、Kajiwara Kentaro、Hiroshima Michio、Akamatsu Kanako、Nada Shigeyuki、Matsumoto Kunio、Ueda Masahiro、Okada Masato
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 3 Pages: 101630-101630
- DOI
  10.1016/j.jbc.2022.101630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03504, KAKENHI-PLANNED-18H05414, KAKENHI-PROJECT-19H00982, KAKENHI-PROJECT-19H03499, KAKENHI-PROJECT-20K06623, KAKENHI-PROJECT-21K18250, KAKENHI-PROJECT-19K07639
[Journal Article] Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients2019
- Author(s)
  Kawamura Miwako、Sato Shigeto、Matsumoto Gen、Fukuda Takahiro、Shiba-Fukushima Kahori、Noda Sachiko、Takanashi Masashi、Mori Nozomu、Hattori Nobutaka
- Journal Title
  
  Neuroscience Letters
  
  Volume: 699 Pages: 59-63
- DOI
  10.1016/j.neulet.2019.01.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-17K07098
[Journal Article] Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy2018
- Author(s)
  Matsumoto Gen、Matsumoto Kazuki、Kimura Taeko、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko、Mori Nozomu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 5 Pages: 1497-1497
- DOI
  10.3390/ijms19051497
- NAID
  120006988072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PROJECT-17K07113, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17J06398
[Journal Article] 超解像蛍光顕微鏡でみるアグリファジーと凝集化タウ2018
- Author(s)
  松本　弦、森望
- Journal Title
  
  Dementia Japan
  
  Volume: 31 Pages: 2-11
- Data Source
  KAKENHI-PROJECT-17K07098
[Journal Article] N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression2018
- Author(s)
  Matsumoto Gen、Inobe Tomonao、Amano Takanori、Murai Kiyohito、Nukina Nobuyuki、Mori Nozomu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-018-27872-6
- NAID
  120006988003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07098, KAKENHI-PROJECT-17K07111, KAKENHI-PUBLICLY-17H05664, KAKENHI-PUBLICLY-18H04544, KAKENHI-PROJECT-17H01564
[Journal Article] マイトファジー：オートファジーアダプターによるユビキチン鎖の認識機構2017
- Author(s)
  松本　弦
- Journal Title
  
  実験医学７月号特集「オルガネロファジー」
  
  Volume: 35 Pages: 1800-1805
- Data Source
  KAKENHI-PROJECT-17K07098
[Journal Article] 選択的オートファジーにおけるオートファジーレセプター2017
- Author(s)
  松本　弦
- Journal Title
  
  実験医学増刊号「Theオートファジー」
  
  Volume: 35 Pages: 2549-2556
- Data Source
  KAKENHI-PROJECT-17K07098
[Journal Article] erine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases2015
- Author(s)
  Kurosawa,M., Matsumoto,G., Sumikura,H., Hatsuta,H., Murayama,S., Sakurai,T., Shimogori,T., Hattori,N. and Nukina,N.
- Journal Title
  
  Neurosci. Res.
  
  Volume: 103 Pages: 64-70
- DOI
  10.1016/j.neures.2015.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01561, KAKENHI-PUBLICLY-15H01567, KAKENHI-PROJECT-25253066, KAKENHI-PROJECT-15K15342, KAKENHI-PROJECT-16H06277
[Journal Article] Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.2015
- Author(s)
  4)Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 4 Pages: 1092-105
- DOI
  10.1093/hmg/ddu522
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-23300128, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-25220103
[Journal Article] TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation.2015
- Author(s)
  Matsumoto G, Shimogori T, Hattori N, Nukina N.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 24 Issue: 15 Pages: 4429-42
- DOI
  10.1093/hmg/ddv179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15342, KAKENHI-PUBLICLY-15H01561, KAKENHI-PUBLICLY-15H01567, KAKENHI-PROJECT-25253066
[Journal Article] The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.2015
- Author(s)
  Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R
- Journal Title
  
  PLoS Genet.
  
  Volume: 11 Issue: 9 Pages: e1005503-e1005503
- DOI
  10.1371/journal.pgen.1005503
- NAID
  120005946994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06773, KAKENHI-PROJECT-26860219, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-15H01561, KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15H04842, KAKENHI-PROJECT-26670442
[Journal Article] Dysregulation of the Proteasome Enhances the Toxicity of ALS-linked Mutant SOD12014
- Author(s)
  Kitamura, A., Inada, N., Kubota, H., Matsumoto, G., Kinjo, M., Morimoto, R.I., Nagata, K
- Journal Title
  
  Genes to Cells
  
  Volume: 3 Issue: 3 Pages: 209-224
- DOI
  10.1111/gtc.12125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-23770215, KAKENHI-PUBLICLY-24111554, KAKENHI-PROJECT-24227009
[Journal Article] マイトファジーの認識機構ー選択的オートファジーの一形態としてー2014
- Author(s)
  松本　弦
- Journal Title
  
  医学のあゆみ
  
  Volume: 250 Pages: 489-494
- Data Source
  KAKENHI-PROJECT-23500434
[Journal Article] Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.2014
- Author(s)
  Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
- Journal Title
  
  PLoS Genet.
  
  Volume: 10 Issue: 12 Pages: 1004861-1004861
- DOI
  10.1371/journal.pgen.1004861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23111003, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24241062, KAKENHI-PROJECT-24390224, KAKENHI-PUBLICLY-26117727, KAKENHI-PROJECT-26293070, KAKENHI-PROJECT-26461280, KAKENHI-PROJECT-26860219
[Journal Article] NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization2014
- Author(s)
  Yamanaka, T., Tosaki, A., Kurosawa, M., Matsumoto, G., Koike, M., Uchiyama, Y., Maity, S.N., Shimogori, T., Hattori, N. & Nukina, N.
- Journal Title
  
  Nat. Commun.
  
  Volume: 5 Issue: 1 Pages: 3354-3354
- DOI
  10.1038/ncomms4354
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-23700430, KAKENHI-PUBLICLY-24111553, KAKENHI-PUBLICLY-24111554, KAKENHI-PROJECT-24659436, KAKENHI-PROJECT-25253066, KAKENHI-PROJECT-25460276
[Journal Article] p62のリン酸化とオートファジー2013
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  Annual Review 2013 神経, 編集：鈴木則宏、祖父江元、荒木信夫、宇川義一、川原信隆
  
  Volume: 1 Pages: 29-36
- Data Source
  KAKENHI-PUBLICLY-24111554
[Journal Article] p62のリン酸化とオートファジー2013
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  Annual Review 2013 神経, 編集：鈴木則宏、祖父江元、荒木信夫、宇川義一、川原信隆
  
  Volume: 1 Pages: 29-36
- Data Source
  KAKENHI-PROJECT-23500434
[Journal Article] 選択的オートファジーによるユビキチン化タンパク質の処理機構2012
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  生体の科学細胞の分子構造と機能ー核以外の細胞小器官
  
  Volume: 63 Pages: 490-491
- Data Source
  KAKENHI-PUBLICLY-24111554
[Journal Article] p62のリン酸化と選択的オートファジー2012
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  BIO Clinica 「神経筋疾患の分子標的治療開発」の各論
  
  Volume: 27 Pages: 18-22
- Data Source
  KAKENHI-PUBLICLY-24111554
[Journal Article] 選択的オートファジーによるユビキチン化タンパク質の処理機構2012
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  生体の科学細胞の分子構造と機能ー核以外の細胞小器官
  
  Volume: 63 Pages: 490-491
- Data Source
  KAKENHI-PROJECT-23500434
[Journal Article] p62のリン酸化と選択的オートファジー2012
- Author(s)
  松本　弦、貫名信行
- Journal Title
  
  BIO Clinica 「神経筋疾患の分子標的治療開発」の各論
  
  Volume: 27 Pages: 18-22
- Data Source
  KAKENHI-PROJECT-23500434
[Journal Article] ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT2012
- Author(s)
  Bauer PO
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 7(1) Issue: 1 Pages: 43-43
- DOI
  10.1186/1750-1326-7-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220007, KAKENHI-PROJECT-22240037, KAKENHI-PROJECT-23500434, KAKENHI-PROJECT-24659436, KAKENHI-PLANNED-22110004, KAKENHI-PUBLICLY-24111554
[Journal Article] Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins2011
- Author(s)
  Matsumoto, G., et al
- Journal Title
  
  Mol.Cell
  
  Volume: 44 Issue: 2 Pages: 279-289
- DOI
  10.1016/j.molcel.2011.07.039
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110004, KAKENHI-PROJECT-22240037, KAKENHI-PROJECT-23500434
[Journal Article] Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases2009
- Author(s)
  Furukawa Y, Kaneko K, Matsumoto G, Kurosawa M, Nukina N.
- Journal Title
  
  J Neurosci. 29
  
  Pages: 5153-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700331
[Patent] タンパク質凝集体の分解促進用組成物、およびタンパク質凝集体形成を伴う神経変性疾患の予防または治療用医薬組成物2023
- Inventor(s)
  松本　弦、水田賢志
- Industrial Property Rights Holder
  国立大学法人　長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-030021
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24214
[Patent] タンパク質凝集体の分解促進用組成物、およびタンパク質凝集体形成を伴う神経変性疾患の予防または治療用医薬組成物2023
- Inventor(s)
  松本　弦、水田賢志
- Industrial Property Rights Holder
  国立大学法人　長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-030021
- Filing Date
  2023
- Data Source
  KAKENHI-PUBLICLY-22H04651
[Patent] タンパク質凝集体の分解促進用組成物、およびタンパク質凝集体形成2023
- Inventor(s)
  松本　弦、水田賢志
- Industrial Property Rights Holder
  松本　弦、水田賢志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-030021
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24214
[Patent] タンパク質凝集体の分解促進用組成物、およびタンパク質凝集体形成2023
- Inventor(s)
  松本弦、水田賢志
- Industrial Property Rights Holder
  長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-030021
- Filing Date
  2023
- Data Source
  KAKENHI-PUBLICLY-22H04651
[Patent] パーキンソン病と多系統萎縮症の鑑別診断2021
- Inventor(s)
  服部信孝波田野琢、奥住文美、松本弦
- Industrial Property Rights Holder
  順天堂大学・長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-000188
- Filing Date
  2021
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] タウ凝集検出プローブの発光率とタウ凝集の相関解析2023
- Author(s)
  内田智也,加藤尚己,服部満,永井健治, 松本弦, 吉村英哲, 高島明彦, 櫻木繁雄, 坂内博子
- Organizer
  新学術領域　シンギュラリティ生物学成果報告シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] Research and Development of Oral Therapeutics for Neurodegenerative Diseases by Aggrepohagy Inducing Compounds2023
- Author(s)
  松本　弦
- Organizer
  BioJapan 2023
- Data Source
  KAKENHI-PROJECT-23K24214
[Presentation] アグリファジー促進化合物 (ADI) による in vivo タウ凝集抑制2023
- Author(s)
  松本弦
- Organizer
  タウ研究ミーティング2023
- Data Source
  KAKENHI-PUBLICLY-22H04651
[Presentation] タウオリゴマー光誘導モデル細胞を用いた多様なタウ凝集の誘導2023
- Author(s)
  櫻木繁雄 ,坂田佳大,Nathaniel Sebastian H. ,松本弦, 添田義行 ,吉村英哲, 高島明彦,坂内博子
- Organizer
  新学術領域　シンギュラリティ生物学成果報告シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] ２分割ルシフェラーゼ再構成法を利用したタウ凝集検出プローブのスクリーニング2023
- Author(s)
  加藤尚己，内田智也，服部満，永井健治，松本弦，吉村英哲，櫻木繁雄，坂内博子
- Organizer
  新学術領域　シンギュラリティ生物学成果報告シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05414
[Presentation] Research and Development of Oral Therapeutics for Neurodegenerative Diseases by Aggrepohagy Inducing Compounds2023
- Author(s)
  松本　弦
- Organizer
  BioJapan 2023
- Data Source
  KAKENHI-PUBLICLY-22H04651
[Presentation] アグリファジー促進化合物 (ADI) による in vivo タウ凝集抑制2023
- Author(s)
  松本　弦
- Organizer
  タウ研究ミーティング2023
- Data Source
  KAKENHI-PROJECT-23K24214
[Presentation] 海洋微生物抽出物をもちいたタウ凝集抑制物質のスクリーニング2022
- Author(s)
  永尾通章, 黒田愛子, 村井清人,松本弦
- Organizer
  第127回日本解剖学会総会　学生セッション
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] S403リン酸化型p62による in vivoタウ凝集抑制2022
- Author(s)
  安田万梨奈, 黒田愛子, 村井清人,松本弦
- Organizer
  第127回日本解剖学会総会　学生セッション
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] タウ凝集細胞モデルによるタウ凝集抑制剤の開発2021
- Author(s)
  松本　弦
- Organizer
  第64回日本神経化学会　シンポジウム「ヒトと社会に役立つタウバイオロジー」
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] アグリファジー制御による線維化タウ凝集体の細胞内分解2021
- Author(s)
  松本　弦
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] p62/SQSTM1リン酸化促進剤によるアグリファジー制御の新規経路2021
- Author(s)
  松本　弦
- Organizer
  新学術研究「マルチモードオートファジー」第3回班会議／第１４回オートファジー研究会
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] 超解像顕微鏡による細胞内タンパク質凝集体の形態解析2020
- Author(s)
  松本　弦、柴田恭明、小路武彦
- Organizer
  第62回日本顕微鏡学会九州支部会・学術講演会
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] アグリファジー促進による線維化タウの細胞内分解2020
- Author(s)
  松本　弦
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05333
[Presentation] Enhancement of aggrephagy by small molecules through S403-phosphorylation of p62/SQSTM12019
- Author(s)
  Gen Matsumoto
- Organizer
  The 9th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] Prion-like propagation of filamentous tau inclusions in cultured neuronal cells,2018
- Author(s)
  Gen Matsumoto
- Organizer
  Asian Pacific Prion Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] p62/SQSTM1-mediated selective autophagy for protein aggregates2018
- Author(s)
  Gen Matsumoto
- Organizer
  Keystone Symposia, “Selective Autophagy” joint with the conference on “Mitochondrial Biology”; N-acyldopamines modulate
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] タウ凝集伝播細胞株における線維化タウ封入体の形成と分解2018
- Author(s)
  松本　弦
- Organizer
  第41回日本分子生物学会年会　ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] アシルドーパミンによるプロテアソーム阻害を伴わないアグリソーム形成2017
- Author(s)
  天野貴徳、松本弦、伊野部智由、村井清人、貫名信行、森望
- Organizer
  第122回日本解剖学会 1STpmE-5
- Place of Presentation
  長崎大学医学部　長崎県長崎市
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] マウス初代培養神経細胞の長期培養による老化神経細胞モデルの構築2017
- Author(s)
  淵野萌子、松本弦、村井清人、森望
- Organizer
  第122回日本解剖学会 3P-15
- Place of Presentation
  長崎大学医学部　長崎県長崎市
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] Tau prion propergation and aggregate formation in cultured neuronal cells2017
- Author(s)
  Gen Matsumoto, Taeko Kimura, Kazuki Matsumoto, Naruhiko Sahara, Nozomu Mori
- Organizer
  Brain Protein Aging and Dementia Control 2nd International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] N-acyldopamine induces p62/SQSTM1 and modulates selective autophagy2017
- Author(s)
  Gen Matsumoto, Tomonao Inobe, Takanori Amano, Nobuyuki Nukina, Nozomu Mori
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07098
[Presentation] 老化神経細胞モデルによる選択的オートファジーの解析2016
- Author(s)
  松本　弦
- Organizer
  千葉大学「時間軸から迫る脳機能」シンポジウム
- Place of Presentation
  千葉県千葉市　千葉大学薬学部120周年記念講堂
- Year and Date
  2016-03-08
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] タンパク質分解の障害を伴わずにアグリソーム形成を誘導する脳内物質2016
- Author(s)
  松本　弦
- Organizer
  第39回日本分子生物学会年会　シンポジウム「神経変性疾患研究の最前線：蛋白質分解の観点から神経変性をみなおす」
- Place of Presentation
  パシフィコ横浜, 神奈川県横浜市
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] 超解像顕微鏡でみる神経細胞のアグリファジー2016
- Author(s)
  松本　弦
- Organizer
  第35回日本認知症学会学術集会　シンポジウム4「神経病理学と新技術」
- Place of Presentation
  東京国際フォーラム　東京都千代田区
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] p62-mediated selective clearance of damaged mitochondria in aged neurons2016
- Author(s)
  Gen Matsumoto
- Organizer
  The 6th Busan-Nagasaki Joint Seminar on Aging Research
- Place of Presentation
  Seacloud Hotel, Busan, Korea
- Year and Date
  2016-03-11
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] 神経老化における神経変性疾患と選択的オートファジー2015
- Author(s)
  松本　弦
- Organizer
  第38回日本基礎老化学会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] p62/SQSTM1依存性選択的オートファジーの神経細胞における制御機構2015
- Author(s)
  松本　弦
- Organizer
  第9回オートファジー研究会
- Place of Presentation
  兵庫県淡路市　淡路夢舞台国際会議場
- Year and Date
  2015-11-17
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] 選択的オートファジーと神経変性疾患2015
- Author(s)
  松本　弦
- Organizer
  難治性疾患実用化研究事業「筋萎縮性側索硬化症(ALS)新規治療法開発を目指した病態解明」平成27年度ワークショップ
- Place of Presentation
  東京都千代田区　都市センターホテル
- Year and Date
  2015-09-25
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] 神経細胞における選択的オートファジー2015
- Author(s)
  松本　弦
- Organizer
  日本解剖学会　第71回九州支部学術集会
- Place of Presentation
  熊本県熊本市　熊本大学医学部
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PUBLICLY-15H01561
[Presentation] TBK1 controls PINK1/Parkin-dependent mitophagy through p62/SQSTM1 phosphorylation2014
- Author(s)
  Gen Matsumoto
- Organizer
  第37回日本神経科学会大会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2014-09-14
- Data Source
  KAKENHI-PROJECT-23500434
[Presentation] p62/SQSTM1リン酸化によるPINK1/Parkin依存性マイトファジーの制御機構2014
- Author(s)
  松本　弦
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県奈良市　奈良県新公会堂
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-23500434
[Presentation] p62のリン酸化による選択的オートファジーの分子機構2013
- Author(s)
  松本　弦
- Organizer
  第7回オートファジー研究会
- Place of Presentation
  静岡県掛川市
- Data Source
  KAKENHI-PUBLICLY-24111554
[Presentation] p62タンパク質のリン酸化による選択的オートファジーの制御2013
- Author(s)
  松本　弦
- Organizer
  第65回　細胞生物学会「プロテオスタシス：細胞内タンパク質の恒常性」
- Place of Presentation
  名古屋市
- Invited
- Data Source
  KAKENHI-PROJECT-23500434
[Presentation] p62タンパク質のリン酸化による選択的オートファジーの制御2013
- Author(s)
  松本　弦
- Organizer
  第65回　細胞生物学会「プロテオスタシス：細胞内タンパク質の恒常性」
- Place of Presentation
  名古屋市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111554
[Presentation] p62のリン酸化による選択的オートファジーの分子機構2013
- Author(s)
  松本　弦
- Organizer
  第7回オートファジー研究会兼新学術領域「オートファジー」第1回班会議
- Place of Presentation
  静岡県掛川市
- Data Source
  KAKENHI-PROJECT-23500434
[Presentation] Phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated protein2011
- Author(s)
  Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., Nukina, N.
- Organizer
  The 2011 Cold Spring Harbor Laboratory meeting on "The Ubiquitin Family", Cold Spring Harbor
- Place of Presentation
  NY, USA(口頭発表)
- Data Source
  KAKENHI-PROJECT-21700398
[Presentation] Phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated protein2011
- Author(s)
  Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., and Nukina, N.
- Organizer
  The 2011 Cold Spring Harbor Laboratory meeting on "The Ubiquitin Family"
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Data Source
  KAKENHI-PROJECT-23500434
[Presentation] Requirement of phosphorylation of p62/SQSTM1 for autophagic degradation of polyubiquitinated proteins2010
- Author(s)
  Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., Nukina, N.
- Organizer
  3rd international symposium on Protein Community,(ポスター)
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-21700398
[Presentation] Requirement of phosphorylation of p62/SQSTM1 for autophagic degradation of polyubiquitinated proteins2010
- Author(s)
  Gen Matsumoto
- Organizer
  3^<rd> international symposium on Protein Community
- Place of Presentation
  奈良
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21700398
[Presentation] Phosphorylation at p62/SQSTM1 promotes selective autophagy of ubiquitinated protein2009
- Author(s)
  Gen Matsumoto
- Organizer
  The 4^<th> International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  北海道・札幌市
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21700398
[Presentation] Phosphorylation at p62/SQSTM1 promotes selective autophagy of ubiquitinated protein2009
- Author(s)
  Gen Matsumoto
- Organizer
  The 4^<th> International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  北海道・札幌
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-20059037
[Presentation] Phosphorylation at p62/SQSTM1 promotes selective autophagy of ubiquitinated protein2009
- Author(s)
  Matsumoto, G., Wada, K., Nukina, N.
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21700398
[Presentation] 転写因子NF-Yの機能破壊はユビキチン・p62の蓄積、小胞体異常を伴う神経変性を誘導する.
- Author(s)
  1.山中智行, 戸崎麻子, 黒澤大, 松本弦, 小池正人, 内山安男, MAITY SN, 下郡智美, 服部信孝, 貫名信行.
- Organizer
  第66回日本細胞生物学会大会.
- Place of Presentation
  奈良（奈良県新公会堂、東大寺総合文化センター）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PLANNED-22110004

1. NUKINA Nobuyuki (10134595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. MIYAZAKI Haruko (80525890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMANAKA Tomoyuki (00381575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Bannai Hiroko (40332340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 高島明彦 (00154774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 廣島通夫 (20392087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松田恵子 (40383765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 塚原完 (00529943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 羽二生久夫 (30252050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 片上幸美 (60722296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大塚俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 下條雅文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 奥住文美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 服部信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 佐藤克也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 中垣岳大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsumoto GEN 松本 弦

MATSUMOTO Gen 松本 弦

Research Projects

Research Products

Co-Researchers

Novel aggrephagy pathway for Tau amyloid degradationPrincipal Investigator

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Regulatory Mechanisms of Aggrephagy that Promote Degradation of Tau AggregatesPrincipal Investigator

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Elucidation of alpha-synuclein aggregation inhibition mechanism by lysophospholipids and development of drug discovery for neurodegenerative diseases

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molecular mechanism of p62/SQSTM1-mediated aggrephagyPrincipal Investigator

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Research on the molecular mechanism of singularity phenomenon in neurological disorders

Principal Investigator

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Regulation mechanism of the selective autophagy though p62/SQSTM1 expressionPrincipal Investigator

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Research Institution

老化神経細胞モデルによる神経変性疾患発症機構の解析Principal Investigator

Principal Investigator

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Research Institution

ストレス条件下における選択的オートファジーの制御機構Principal Investigator

Principal Investigator

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Review Section

Research Institution

Regulatory mechanism of p62 gene expressionPrincipal Investigator

Principal Investigator

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Research Institution

The development and analysis of selective neuronal pathology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism underlying selective autophagy of aggregated proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ストレス条件下における異常タンパク質隔離の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism behind the nuclear export of huntingtin protiensPrincipal Investigator

Principal Investigator

Project Period (FY)

Matsumoto GEN 松本弦

MATSUMOTO Gen 松本弦