Sekiya Motohiro 関谷元博

… Alternative Names

関谷元博セキヤモトヒロ

SEKIYA Motobiro 関谷元博

Less

Researcher Number	50420245
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 筑波大学, 医学医療系, 准教授 2018 – 2020: 筑波大学, 医学医療系, 准教授 2017: 筑波大学, 医学医療系, 講師 2009 – 2010: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, Hospital, Research fellow 2006 – 2007: 東京大学, 医学部附属病院, 医員 2006: 東大, 医学部附属病院
Review Section/Research Field	Principal Investigator Metabolomics / Medium-sized Section 52:General internal medicine and related fields / Basic Section 54040:Metabolism and endocrinology-related / Health science and related fields Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Metabolomics
Keywords	Principal Investigator 代謝産物センサー / センサー / 代謝産物 / 低出生体重 / 発達障害 / 周産期異常 / 小分子化合物 / ジヌクレオチド / 脂肪酸 / 脂肪酸CoA … More / NADH / メタボリックシンドローム / 肥満 / ゲノム / 脂質 / 糖尿病 / 内科 / 発現制御 / 代謝 / 膵β細胞 / インスリン / エピゲノム / 水解 / 泡沫化 / マクロファージ / コレステロールエステル / コレステロール … More Except Principal Investigator 脂質代謝 / 転写因子 / 脂肪酸 / 脂質 / エネルギーセンサー / 脂肪肝炎 / 代謝制御 / オルガネラリピッドコード / 脂肪酸伸長酵素 / 脂肪毒性 / ライブセルイメージング / 酵素 / リピドミクス / オルガネラ / ミトコンドリア / 小胞体 / 多価不飽和脂肪酸 / transcrintional regulation / triglycerides / obesity / 転写調節 / 中性脂肪 / 肥満 Less

代謝産物センサー分子を標的した低出生体重児、発達障害児増加の理解と医療応用Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  University of Tsukuba
Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application
- Principal Investigator
  
  島野仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
Unraveling and exploitation of novel metabolic system regulated by a metabolite sensorPrincipal Investigator
- Principal Investigator
  
  Sekiya Motohiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  University of Tsukuba
Molecular mechanism of organella homeostasis regulated by quantity and quality of lipids
- Principal Investigator
  
  SHIMANO HITOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  University of Tsukuba
unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator
- Principal Investigator
  
  Sekiya Motohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Health science and related fields
- Research Institution
  University of Tsukuba
マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator
- Principal Investigator
  
  関谷元博
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
in vivo promoter analysis of lipogenic genes
- Principal Investigator
  
  YAHAGI Naoya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2020 2019 2018 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] 医学のあゆみ[TOPICS]2022
- Author(s)
  関谷　元博
- Total Pages
  2
- Publisher
  石躍出版
- Data Source
  KAKENHI-PROJECT-20K08855
[Journal Article] Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia2024
- Author(s)
  Furuta Yasuhisa、Osaki Yoshinori、Nakagawa Yoshimi、Han Song-Iee、Araki Masaya、Shikama Akito、Ohuchi Nami、Yamazaki Daichi、Suzuki Hiroaki、Shimano Hitoshi et al.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 31 Issue: 9 Pages: 1304-1318
- DOI
  10.5551/jat.64579
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2024-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19886, KAKENHI-PROJECT-22K17769, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-23K23562
[Journal Article] C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity2024
- Author(s)
  Sekiya Motohiro、Kainoh Kenta、Saito Kenji、Yamazaki Daichi、Tsuyuzaki Tomomi、Chen Wanpei、Kobari Yuto、Nakata Ayumi、Babe Haruka、Shimano Hitoshi
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 31 Issue: 2 Pages: 109-116
- DOI
  10.5551/jat.RV22014
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00474
[Journal Article] Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids2023
- Author(s)
  Han Song-Iee、Nakakuki Masanori、Nakagawa Yoshimi、Takeda Hiroyuki、Mizunoe Yuhei、Kainoh Kenta、Murayama Yuki、Aita Yuichi、Takeuchi Yoshinori、Osaki Yoshinori、Miyamoto Takafumi、Sekiya Motohiro、Matsuzaka Takashi、Yahagi Naoya、Sone Hirohito、Daitoku Hiroaki、Sato Ryuichiro、Kawano Hiroyuki、Shimano Hitoshi
- Journal Title
  
  PNAS Nexus
  
  Volume: 2 Issue: 11 Pages: 1-14
- DOI
  10.1093/pnasnexus/pgad351
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18342, KAKENHI-PROJECT-23K18444, KAKENHI-PROJECT-23K19886, KAKENHI-PROJECT-22K11851, KAKENHI-PROJECT-22K17769, KAKENHI-PROJECT-20H00408, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-23K23562
[Journal Article] Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure2023
- Author(s)
  Motomura K, Matsuzaka T, Shichino S, Ogawa T, Pan H, Nakajima T, Asano Y, Okayama T, Takeuchi T, Ohno H, Han SI, Miyamoto T, Takeuchi Y, Sekiya M, Sone H, Yahagi N, Nakagawa Y, Oda T, Ueha S, Ikeo K, Ogura A, Matsushima K, Shimano H.
- Journal Title
  
  Diabetes
  
  Volume: 73 Issue: 1 Pages: 75-92
- DOI
  10.2337/db23-0212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18444, KAKENHI-PROJECT-22K12043, KAKENHI-PROJECT-22K17769, KAKENHI-PLANNED-22H05064, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-23K23562
[Journal Article] Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity2023
- Author(s)
  Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, Araki M, Ohno H, Takeuchi Y, Tsuyuzaki T, Yamazaki D, Wanpei C, Hada L, Watanabe S, Paramita Adi Putri PI, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Miyamoto T, Matsuzaka T, Shimano H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 7 Pages: 104890-104890
- DOI
  10.1016/j.jbc.2023.104890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18444, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-23K23562
[Journal Article] Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function2023
- Author(s)
  Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H.
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 8 Pages: 112914-112914
- DOI
  10.1016/j.celrep.2023.112914
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18444, KAKENHI-PROJECT-22H00474, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-23K23562
[Journal Article] A case of early-onset diabetes with impaired insulin secretion carrying a PAX6 gene Gln135* mutation2022
- Author(s)
  Motohiro Sekiya 1, Mikiko Yuhara 1, Yuki Murayama 1, Mariko Ohyama Osawa 1, Rikako Nakajima 1, Nami Ohuchi 1, Nako Matsumoto 1, Daichi Yamazaki 1, Sayuri Mori 1, Takaaki Matsuda 1, Yoko Sugano 1, Yoshinori Osaki 1, Hitoshi Iwasaki 1, Hiroaki Suzuki 1, Hitoshi Shimano 1
- Journal Title
  
  Endocrinol Diabetes Metab Case Rep .
  
  Volume: Aug 1 Pages: 22-0271
- DOI
  10.1530/edm-22-0271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08855
[Journal Article] A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction.2022
- Author(s)
  Nakajima R, Sekiya M, Furuta Y, Miyamoto T, Sato M, Fukuda K, et, al.
- Journal Title
  
  Endocrinol Diabetes Metab Case Rep.
  
  Volume: 22 Pages: 0368-0368
- DOI
  10.1530/edm-22-0368
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08072, KAKENHI-PROJECT-21H03371, KAKENHI-PROJECT-20K08855, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-19K17820, KAKENHI-PROJECT-23K21443, KAKENHI-PROJECT-23K23562, KAKENHI-PROJECT-21K16262
[Journal Article] Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion2020
- Author(s)
  Sekiya Motohiro、Matsuda Takaaki、Yamamoto Yuki、Furuta Yasuhisa、Ohyama Mariko、Murayama Yuki、Sugano Yoko、Ohsaki Yoshinori、Iwasaki Hitoshi、Yahagi Naoya、Yatoh Shigeru、Suzuki Hiroaki、Shimano Hitoshi
- Journal Title
  
  BMC Medical Genetics
  
  Volume: 21 Issue: 1 Pages: 91-91
- DOI
  10.1186/s12881-020-01031-z
- NAID
  120007147873
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21611, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051
[Journal Article] CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms2020
- Author(s)
  Satoh Aoi、Han Song-iee、Araki Masaya、Nakagawa Yoshimi、Ohno Hiroshi、Mizunoe Yuhei、Kumagai Kae、Murayama Yuki、Osaki Yoshinori、Iwasaki Hitoshi、Sekiya Motohiro、Konishi Morichika、Itoh Nobuyuki、Matsuzaka Takashi、Sone Hirohito、Shimano Hitoshi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 3 Pages: 100930-100930
- DOI
  10.1016/j.isci.2020.100930
- NAID
  120006891020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07095, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-19H00449, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-19K11737, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18KT0065
[Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice2020
- Author(s)
  Matsuzaka T、Kuba M、Koyasu S、Yamamoto Y、Motomura K、Arulmozhiraja S、Ohno H、Sharma R、Shimura T、Okajima Y、Han SI、Aita Y、Mizunoe Y、Osaki Y、Iwasaki H、Yatoh S、Suzuki H、Sone H、Takeuchi Y、Yahagi N、Miyamoto T、Sekiya M、Nakagawa Y、Ema M、Takahashi S、Tokiwa H、Shimano H
- Journal Title
  
  Hepatology
  
  Volume: 71 Issue: 5 Pages: 1609-1625
- DOI
  10.1002/hep.30953
- NAID
  120007132717
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20175, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-20K21611, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18K06206
[Journal Article] Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT12020
- Author(s)
  Ma Yang、Sekiya Motohiro、Kainoh Kenta、Matsuda Takaaki、Iwasaki Hitoshi、Osaki Yoshinori、Sugano Yoko、Suzuki Hiroaki、Takeuchi Yoshinori、Miyamoto Takafumi、Yahagi Naoya、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 2 Pages: 354-360
- DOI
  10.1016/j.bbrc.2019.12.070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-18K19724, KAKENHI-PROJECT-20K07272, KAKENHI-PROJECT-18K06206
[Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex2019
- Author(s)
  Murayama Yuki, Takafumi Miyamoto, et al.
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 4 Pages: 423-432
- DOI
  10.1002/1873-3468.13328
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17K12895, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H05060, KAKENHI-PROJECT-17K00846
[Journal Article] Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism2019
- Author(s)
  Sharma Rahu, Takafumi Miyamoto, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 5169-5169
- DOI
  10.1038/s41598-019-41631-1
- NAID
  120007133465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06206, KAKENHI-PROJECT-18K19724, KAKENHI-PLANNED-17H06395, KAKENHI-PUBLICLY-18H04854, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] Molecular association model of PPARα and its new specific and efficient ligand, pemafibrate: Structural basis for SPPARMα2018
- Author(s)
  Yamamoto Yuta、Takei Kenta、Arulmozhiraja Sundaram、Sladek Vladimir、Matsuo Naoya、Han Song-iee、Matsuzaka Takashi、Sekiya Motohiro、Tokiwa Takaki、Shoji Mitsuo、Shigeta Yasuteru、Nakagawa Yoshimi、Tokiwa Hiroaki、Shimano Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 2 Pages: 239-245
- DOI
  10.1016/j.bbrc.2018.03.135
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16H03253, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16K01811
[Journal Article] Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.2018
- Author(s)
  Ohno H, Matsuzaka T, Tang N, Sharma R, Motomura K, Shimura T, Satoh A, Han SI, Takeuchi Y, Aita Y, Iwasaki H, Yatoh S, Suzuki H, Sekiya M, Nakagawa Y, Sone H, Yahagi N, Yamada N, Higami Y, Shimano H.
- Journal Title
  
  Endocrinology.
  
  Volume: 159(6) Issue: 6 Pages: 2308-2323
- DOI
  10.1210/en.2017-03179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19724, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-18H03189, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K13217, KAKENHI-PROJECT-17H05060
[Journal Article] The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice2018
- Author(s)
  Araki Masaya、Nakagawa Yoshimi、Oishi Asayo、Han Song-iee、Wang Yunong、Kumagai Kae、Ohno Hiroshi、Mizunoe Yuhei、Iwasaki Hitoshi、Sekiya Motohiro、Matsuzaka Takashi、Shimano Hitoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 7 Pages: 2148-2148
- DOI
  10.3390/ijms19072148
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-16J00187, KAKENHI-PROJECT-16K01811
[Journal Article] Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Biochem Biophys Res Commun 387
  
  Pages: 511-515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.2009
- Author(s)
  Sekiya M., et al.
- Journal Title
  
  Cell Metab 10(3)
  
  Pages: 219-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890053
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008
- Author(s)
  Sekiya M, et. al.
- Journal Title
  
  J Lipid Res (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis2008
- Author(s)
  Sekiya M, Osuga J, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yanagi N, et al.
- Journal Title
  
  J Lipid Res (in press)
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein (SREBP)-1-independent regulation of lipogenic gene expression in adipocytes.2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590979
[Journal Article] Sterol regulatory element-binding protein(SREBP) -1-independent regulation of lipogenic gene expression in adipocytes2007
- Author(s)
  Sekiya M, Yahagi N, et. al.
- Journal Title
  
  J Lipid Res 48
  
  Pages: 1581-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 分岐鎖アミノ酸(BCAA)は高齢2型糖尿病患者のQIDSスコアを有意に改善する　探索的ランダム化比較試験2024
- Author(s)
  松田　高明、鈴木　浩明、菅野　洋子、鈴木　康裕、山中　大介、荒木　理沙、矢作　直也、関谷　元博、川上　康、大崎　芳典、岩崎　仁、橋本　幸一、高橋　信一郎、羽田　康司、島野　仁
- Organizer
  第27回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 脂質・リポ蛋白代謝研究の最前線:創薬の鍵を探る　代謝産物センサー分子CtBP2の代謝制御における重要な役割とその医療応用の可能性2023
- Author(s)
  関谷　元博、馬　洋、戒能　健太、斎藤　賢治、山崎　大地、露崎　朋美、陳　婉培、島野　仁
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 酸化ストレス応答におけるレドックスセンサー分子CtBP2の転写調節機能の解明2023
- Author(s)
  戒能　賢太、関谷　元博、斎藤　賢治、山崎　大地、露崎　朋未、陳　婉培、Putu lndah、大越　萌子、馬部　遥香、島野　仁
- Organizer
  第58回日本臨床分子医学会学術総会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 代謝産物センサー分子CtBP2を中心とした新しい代謝病態の理解2023
- Author(s)
  関谷　元博
- Organizer
  第11回AAA研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08855
[Presentation] チルゼパチドへの切り替えが奏功したCABG術前の2型糖尿病の一例2023
- Author(s)
  松本　なこ、村山　友樹、東　尭世、相馬　奈生、江面　彩、佐藤　大輔、三谷　優太、菊池　裕一、松田　高明、大崎　芳典、菅野　洋子、岩崎　仁、関谷　元博、鈴木　浩明、島野　仁
- Organizer
  第33回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] チルゼパチドにより食欲抑制、体重減少した肥満合併糖尿病の一例2023
- Author(s)
  相馬　奈生、菊池　裕一、村山　友樹、東　尭世、江面　彩、佐藤　大輔、三谷　優太、松本　なこ、松田　高明、大崎　芳典、菅野　洋子、岩崎　仁、関谷　元博、鈴木　浩明、島野　仁
- Organizer
  第33回臨床内分泌代謝Update
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 代謝産物センサーCtBP2は肥満における膵β細胞機能不全に重要な役割を果たす2023
- Author(s)
  関谷　元博、馬　洋、戒能　賢太、斎藤　賢治、山崎　大地、露崎　朋美、島野　仁
- Organizer
  第96回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] アテゾリズマブ投与後に急性発症1型糖尿病を発症した1例2023
- Author(s)
  大内　奈美、大崎　芳典、菊池　裕一、村山　友樹、菅野　洋子、岩崎　仁、関谷　元博、矢作　直也、鈴木　浩明、島野　仁
- Organizer
  第686回日本内科学会関東地方会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 代謝産物センサー分子CtBP2は肥満における膵β細胞機能不全の病態に重要な役割を果たす2023
- Author(s)
  関谷　元博、馬　洋、戒能　賢太、斎藤　賢治、山崎　大地、露崎　朋美、陳　婉培、大越　萌子、島野　仁
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 転写抑制因子であるCtBP2はPPARαと結合しその転写活性を抑制する2023
- Author(s)
  斎藤　賢治、関谷　元博、戒能　賢太、山崎　大地、露崎　朋未、陳　婉培、Putu lndah、大越　萌子、馬部　遥香、島野　仁
- Organizer
  第58回日本臨床分子医学会学術総会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 肥満・脂肪細胞・インスリン抵抗性　代謝産物センサー分子CtBP2は肥満におけるメタボリックシンドローム病態形成に重要な役割を果たしている2023
- Author(s)
  関谷　元博、戒能　賢太、斎藤　賢治、馬　洋、山崎　大地、露崎　朋美、陳　婉培、小針　悠斗、島野　仁
- Organizer
  第38回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] SREBP-1aによる脂質合成の制御と食餌誘導性脂肪肝炎の病態2023
- Author(s)
  荒木　雅弥、韓　松伊、大崎　芳典、松坂　賢、矢作　直也、関谷　元博、宮本　崇史、中川　嘉、島野　仁
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 分岐鎖アミノ酸補充が高齢2型糖尿病患者の骨格筋,耐糖能,腎機能に与える影響　探索的ランダム化比較試験2023
- Author(s)
  松田　高明、鈴木　浩明、菅野　洋子、鈴木　康裕、山中　大介、荒木　理沙、矢作　直也、関谷　元博、川上　康、大崎　芳典、岩崎　仁、橋本　幸一、高橋　伸一郎、羽田　康司、島野　仁
- Organizer
  第66回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-22H00474
[Presentation] 代謝産物センサー分子CtBP2を中心としたメタボリックシンドローム病態形成の新しい理解2022
- Author(s)
  関谷　元博、馬　洋、戒能　賢太、斎藤　賢治、島野　仁
- Organizer
  第8回　肝臓と糖尿病・代謝研究会
- Data Source
  KAKENHI-PROJECT-20K08855
[Presentation] 代謝産物センサー分子CtBP2を中心とした脂肪肝病態形成の新しい理解2022
- Author(s)
  関谷　元博、馬　洋、斎藤　賢治、戒能　賢太、島野　仁
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K08855
[Presentation] 代謝産物センサーCtBP2は肥満における肝臓の糖・脂質代謝異常に重要な役割を果たす2022
- Author(s)
  関谷　元博、馬　洋、斎藤　賢治、戒能　賢太、島野　仁
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08855
[Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020
- Author(s)
  松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博, 中川嘉, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 腸肝転写因子CREBHはSREBPの活性を制御し、動脈硬化発症を抑制する(会議録)2020
- Author(s)
  中川嘉, 王雨農, 韓松伊, 水之江雄平, 荒木雅弥, 関谷元博, 松坂賢, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 亜急性甲状腺炎発症後バセドウ病が明らかになった2症例2020
- Author(s)
  菅野洋子, 中島里佳子, 大山真理子, 村山友樹, 大崎芳典, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 患側と考えられた副腎摘出後も改善が無く治療に苦慮した副腎髄質過形成の一例2020
- Author(s)
  古田泰久, 大崎芳典, 山本由季, 大山真理子, 村山友樹, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 笹野公伸, 竹越一博, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] メタボリックシンドロームの病態形成に重要と考えられる代謝産物センサー分子CtBP2の活性化化合物の探索2020
- Author(s)
  戒能賢太, 関谷元博, 松田高明, 馬洋, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 肝臓特異的Elovl6欠損マウスの肝臓ではC18-ceramideが減少することによりインスリン感受性が亢進する2020
- Author(s)
  松坂賢, 久芳素子, 小安さおり, 本村香織, 大野博, Rahul Sharma, 武内謙憲, 矢作直也, 宮本崇史, 関谷元博, 中川嘉, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 栄養環境センシングと制御(の分子基盤)　代謝産物センサー分子CtBP2を中心とした新しい代謝制御システムの同定2020
- Author(s)
  関谷元博, 戒能賢太, 馬洋, 松田高明, Gokhan Hotamisligil, 島野仁
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 成人後の治療自己中断中に糖尿病を契機に指摘された、POUF1/PIT-1遺伝子異常によると考えられる複合型下垂体機能低下症の一例2020
- Author(s)
  新田葉月, 村山友樹, 中島里佳子, 大山真理子, 大崎芳典, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 鈴木浩明, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 機械学習を用いた原発性アルドステロン症病型診断の試み2020
- Author(s)
  鈴木浩明(筑波大学医学医療系内分泌代謝・糖尿病内科), 松田えりか, 松田高明, 古田泰久, 村山友樹, 戒能賢太, 大崎芳典, 菅野洋子, 岩崎仁, 関谷元博, 矢作直也, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 中年期2型糖尿病者の認知機能低下の特徴と、におい、バランスとの関連2020
- Author(s)
  緑川学, 鈴木浩明, 鈴木康裕, 椿拓海, 田邉裕基, 山内一由, 佐藤泰之, 根本清貴, 菅野洋子, 岩崎仁, 関谷元博, 矢藤繁, 矢作直也, 羽田康司, 新井哲明, 島野仁
- Organizer
  第 63 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] グルココルチコイドによるGR-Bmal/Clock複合体を介した時計遺伝子Nr1d1の抑制性転写制御機構2020
- Author(s)
  村山友樹, 矢作直也, 武内謙憲, 會田雄一, 何敏煕, Mehrazad Saber Zahra, 志鎌明人, 升田紫, 泉田欣彦, 宮本崇史, 関谷元博, 中川嘉, 松坂賢, 大崎芳典, 菅野洋子, 岩崎仁, 鈴木浩明, 川上康, 島野仁
- Organizer
  第89回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 脂肪酸伸長酵素Elovl6による神経新生の制御機構解明2020
- Author(s)
  大野博, 松坂賢, 本村香織, 志村拓哉, 宮本崇史, 関谷元博, 中川嘉, 島野
- Organizer
  日本臨床分子医学会学術総会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 学際研究で切り拓く脂質とアミノ酸のメタボダイナミズム　脂肪酸の量と質とセンシングの視点からみた脂質多様性とメタボダイナミズム2020
- Author(s)
  島野仁, 松坂賢, 関谷元博, 宮本崇史
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] A metabolite sensor CtBP2 integrates metabolic flux to orchestrate glucose and lipid homeostasis in liver2019
- Author(s)
  Motohiro Sekiya, Hitoshi Shimano, Gokhan Hotamisligil
- Organizer
  60th International Conference on the Bioscience of Lipids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 転写因子CREBHの未成熟型・成熟型による動脈硬化形成に対する二重支配の分子メカニズム2018
- Author(s)
  中川嘉、韓松伊、大石麻代、王雨農、関谷元博、松坂賢、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 代謝産物センサーによる新しい脂質・糖代謝制御システムの解明と医療応用2018
- Author(s)
  関谷元博、菅澤威仁、馬　洋、戒能賢太、関根七海、Gokhan Hotamisligil、島野仁
- Organizer
  第50回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H04051
[Presentation] 新規に同定されたリパーゼNCEHはマクロファージの主要な中性コレステロールエステラーゼである2009
- Author(s)
  関谷元博
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] A Novel Lipase, Neutral Cholesterol Ester Hydrolase, is a major regulator of Neutral Cholesterol Ester Hydrolysis in Macrophages.2009
- Author(s)
  関谷元博
- Organizer
  第41回日本動脈硬化学会総会・学術集会
- Place of Presentation
  山口
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21890053
[Presentation] 新規に同定されたマクロファージコレステロールエズテラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラーゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博、他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたマクロファージコレステロールエステラゼ(MCEH)は泡沫化現象を規定するリパーゼである2007
- Author(s)
  関谷元博, 他
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] 新規に同定されたコレステロールエステラーゼ(MCEH)は未同定であったマクロファージの中性コレステロールエステラーゼである2006
- Author(s)
  関谷元博, 他
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージに発現する新規コレステロールエステラーゼ(macrophage cholesteryl ester hydrolase, MCEH)ノックアウトマウスの解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第38回日本動脈硬化学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979
[Presentation] マクロファージにおいて新規に同定されたコレステロールエステラーゼ(MCEH)のin vivo解析2006
- Author(s)
  関谷元博, 他
- Organizer
  第49回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590979

1. SHIMANO HITOSHI (20251241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
2. 松坂賢 (70400679)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. YAHAGI Naoya (60420246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. OSUGA Jun-ichi (10334400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IIZUKA Yoko (40420244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 韓松伊 (80729541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 中川嘉 (80361351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. 大野博 (20847909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮本崇史 (50740346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. FUKUDA Kuniaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小西守周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 佐藤隆一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 會田雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekiya Motohiro 関谷 元博

関谷 元博 セキヤ モトヒロ

SEKIYA Motobiro 関谷 元博

Research Projects

Research Products

Co-Researchers

代謝産物センサー分子を標的した低出生体重児、発達障害児増加の理解と医療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fatty acid diversity and its sensing mechanism for metabolic control and therapeutic application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling and exploitation of novel metabolic system regulated by a metabolite sensorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of organella homeostasis regulated by quantity and quality of lipids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

unraveling an epigenetic system by targeting a novel metabolite sensor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージ泡沫化における新規代謝調節因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪組織における新規中性脂肪分解酵素遺伝子欠損マウスの表現型解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

in vivo promoter analysis of lipogenic genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ[TOPICS]2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] C-Terminal Binding Protein 2 Emerges as a Critical Player Linking Metabolic Imbalance to the Pathogenesis of Obesity2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids2023

Author(s)

Journal Title

DOI

Data Source

Sekiya Motohiro 関谷元博

関谷元博セキヤモトヒロ

SEKIYA Motobiro 関谷元博