Yamahara Kenichi 山原研一

… Alternative Names

山原研一ヤマハラケンイチ

YAMAHARA Kenichi 山原研一

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Researcher Number	50450888
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 兵庫医科大学, 医学部, 教授 2022 – 2023: 兵庫医科大学, 医学部, 教授 2017 – 2021: 兵庫医科大学, 医学部, 准教授 2017: 国立研究開発法人国立循環器病研究センター, その他部局等, その他 2015: 国立研究開発法人国立循環器病研究センター, その他部局等, その他 … More 2014: 国立循環器病研究センター, 研究所, 室長 2013 – 2014: 独立行政法人国立循環器病研究センター, 研究所・再生医療部, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, その他部局等, その他 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2012: 国立循環器病研究センター, 再生医療部, 室長 2009 – 2012: National Cardiovascular Center Research Institute, 再生医療部, 室長 2009 – 2011: 国立循環器病センター, 再生医療部, 室長 2008: National Cardiovascular Center Research Institute, 再生医療部, 室長 2007 – 2008: 国立循環器病センター研究所, 再生医療部, 室長 2007: National Cardiovascular Center Research Institute, 研究所・再生医療部, 室長 Less
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Cardiovascular surgery / Circulatory organs internal medicine / Endocrinology Except Principal Investigator Basic Section 56010:Neurosurgery-related / Radiation science / Obstetrics and gynecology / Cardiovascular surgery / Embryonic/Neonatal medicine / Applied pharmacology / Thoracic surgery / Kidney internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator 血管新生 / 再生医療 / M2マクロファージ / 臍帯血 / 血管平滑筋 / オートファジー / 循環器・高血圧 / マイクロアレイ / EPC(内皮前駆細胞) / iPS細胞 … More / 血管前駆細胞 / 血管平滑筋細胞 / 血管内皮細胞 / マイクロRNA(miRNA) / ES細胞 / 炎症 / リンパ管新生 / アドレノメデュリン / リンパ管 / 血管内皮 / 脂肪 / メタボリックシンドローム / アディポサイトカイン / 生理活性物質 … More Except Principal Investigator 間葉系幹細胞 / 脳出血 / iPS細胞 / 細胞治療 / 分子イメージング / 再生医療 / 幹細胞 / 臍帯間葉系幹細胞 / 炎症抑制 / 臍帯由来間葉系幹細胞 / 羊膜 / 羊膜由来幹細胞 / 羊膜由来間葉系幹細胞 / 器官芽 / 胎盤機能再生 / ヒトiPS細胞 / 妊娠高血圧症候群 / 胎盤機能不全 / 人工胎盤 / 胎児機能不全 / 妊娠高血圧腎症 / 胎盤機能再生医療 / 胎盤形成不全 / placental organoid / 核医学（PETを含む） / 抗炎症療法 / 脳傷害 / 低酸素性虚血 / 脳梗塞 / 虚血 / 脳障害 / 新生児 / CD34陽性細胞 / 中大脳動脈閉塞 / 臍帯血幹細部 / 脳血流 / マウス / 臍帯血 / 新生児低酸素性虚血性脳症 / 新生児脳症 / 新生児脳梗塞 / 心筋梗塞 / 他家移植 / 細胞シート / 卵膜 / 胎児付属物 / 細胞・組織 / レンチウイルス / 血管リモデリング / エレクトロポレーション / 冠動脈バイパス術 / 虚血性心疾患 / miRNA / 内膜肥厚 / 血管平滑筋 / ミクロRNA / 再生治療 / 心臓移植 / 遺伝子治療 / 循環器 / 核医学(PETを含む) / 虚血再還流傷害 / サイトカイン / 間葉系線細胞移植 / 尿細管細胞 / 卵膜由来幹細胞 / 間葉系幹細胞移植 / 再生 / 虚血再灌流傷害 / 腎炎 / 移植 / 薬理学 / 発現抑制 / 循環器・高血圧 / シグナル伝達 / 核酸 Less

骨髄由来血管新生誘導細胞を用いた脳梗塞後遺症に対する細胞治療研究Principal Investigator
- Principal Investigator
  
  山原研一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
Cell therapy research using human umbilical cord blood-derived hemangioblast-like cells for the treatment of cerebral infarctionPrincipal Investigator
- Principal Investigator
  
  山原研一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
Development of a novel treatment method using umbilical cord-derived mesenchymal stem cells for cerebral hemorrhage and investigation of their mechanism
- Principal Investigator
  
  吉村紳一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
Novel treatment for intracranial hemorrhage using amnion derived mesenchymal stem cells
- Principal Investigator
  
  Yoshimura Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hyogo Medical University
Three-dimensional human placental buds synthesized from induced pluripotent stem cells for regenerative therapy that can restore placental function
- Principal Investigator
  
  Kondoh Eiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Molecular Imaging of Transplanted Stem Cells Derived from Original NIS Transgenic Mouse
- Principal Investigator
  
  INUBUSHI Masayuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kawasaki Medical School
ヒトiPS細胞由来間葉系細胞による心臓外科領域の全身炎症反応制御法の開発
- Principal Investigator
  
  丸井晃
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular surgery
- Research Institution
  Kyoto University
Modulation of autophagic cell death to develop a new therapy for cardiovascular diseasesPrincipal Investigator
- Principal Investigator
  
  YAMAHARA KENICHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular surgery
- Research Institution
  National Cardiovascular Center Research Institute
Umbilical cord blood cell therapies in a novel neonatal stroke model
- Principal Investigator
  
  TSUJI MASAHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of method for the systemic separation of fetal membrane-derived MSCs to establish the cell-specific transplantation therapy
- Principal Investigator
  
  IKEDA TOMOAKI
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  National Cardiovascular Center Research Institute
Molecular Imaging Research for Forefront of Cardiovascular Medicine
- Principal Investigator
  
  INUBUSHI Masayuki
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kawasaki Medical School
  National Institute of Radiological Sciences
Development of novel treatment method forcardiovascular disorders with phenotype regulation of vascular cells using micro RNAs
- Principal Investigator
  
  MINAKATA Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyoto University
Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protect kidney
- Principal Investigator
  
  ISAKA Yoshitaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Osaka University
Development of new vascular regenerative therapy by replacement of bone marrow cells with pluripotent stem cell-derived vascular progenitor cells.Principal Investigator
- Principal Investigator
  
  YAMAHARA Kenichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
siRNAを用いた肺高血圧治療法の開発
- Principal Investigator
  
  永谷憲歳
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of new regenerative therapy for cardiovascular, neural, and metabolic diseases using bioactive peptidesPrincipal Investigator
- Principal Investigator
  
  YAMAHARA Kenichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  National Cardiovascular Center Research Institute

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All Journal Article Presentation Book Patent

[Book] 血管の再生-血管再生医学の夜明け:近づく実用化2008
- Author(s)
  山原研一、伊藤裕
- Total Pages
  251
- Publisher
  真興交易(株)医書出版部
- Data Source
  KAKENHI-PROJECT-19790656
[Book] 血管の再生-血管再生医学の夜明げ:近づく実用化2008
- Author(s)
  山原研一, 他
- Total Pages
  251
- Publisher
  真興交易(株)医書出版部
- Data Source
  KAKENHI-PROJECT-19790656
[Book] 血管の再生2008
- Author(s)
  山原研一、曽根正勝、伊藤裕
- Publisher
  真興出版
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Enhanced angiogenic properties of umbilical cord blood primed by OP9 stromal cells ameliorates neurological deficits in cerebral infarction mouse model2023
- Author(s)
  Yoshida Yasunori、Takeda Yuki、Yamahara Kenichi、Yamamoto Hanae、Takagi Toshinori、Kuramoto Yoji、Nakano-Doi Akiko、Nakagomi Takayuki、Soma Toshihiro、Matsuyama Tomohiro、Doe Nobutaka、Yoshimura Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 262-262
- DOI
  10.1038/s41598-023-27424-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09221
[Journal Article] Early-phase administration of human amnion-derived stem cells ameliorates neurobehavioral deficits of intracerebral hemorrhage by suppressing local inflammation and apoptosis2022
- Author(s)
  Kuramoto Yoji、Fujita Mitsugu、Takagi Toshinori、Takeda Yuki、Doe Nobutaka、Yamahara Kenichi、Yoshimura Shinichi
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 19 Issue: 1 Pages: 48-48
- DOI
  10.1186/s12974-022-02411-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09539, KAKENHI-PROJECT-20K09378
[Journal Article] ntraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia2015
- Author(s)
  Ohshima M, Taguchi A, Tsuda H, Sato Y, Yamahara K, Harada-Shiba M, Miyazato M, Ikeda T, Iida H, Tsuji M
- Journal Title
  
  Brain Dev
  
  Volume: 37 Issue: 4 Pages: 376-386
- DOI
  10.1016/j.braindev.2014.06.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591617, KAKENHI-PROJECT-26461630
[Journal Article] Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats.2015
- Author(s)
  Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N.
- Journal Title
  
  Cell Transplant.
  
  Volume: -
- NAID
  120005690898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390145
[Journal Article] Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke.2014
- Author(s)
  Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T.
- Journal Title
  
  Neuroscience
  
  Volume: 263 Pages: 148-158
- DOI
  10.1016/j.neuroscience.2014.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23500448, KAKENHI-PROJECT-23791220, KAKENHI-PROJECT-24591617, KAKENHI-PROJECT-25640031, KAKENHI-PROJECT-26461630
[Journal Article] Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells.2014
- Author(s)
  Yamahara K, Harada K, Ohshima M, Ishikane S, Ohnishi S, Tsuda H, Otani K, Taguchi A, Soma T, Ogawa H, Katsuragi S, Yoshimatsu J, Harada-Shiba M, Kangawa K, Ikeda T.
- Journal Title
  
  PLoS One. 2014 Feb 14;9(2):e88319.
  
  Volume: 9 Issue: 2 Pages: e88319-e88319
- DOI
  10.1371/journal.pone.0088319
- NAID
  40020640332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390145, KAKENHI-PROJECT-23700569, KAKENHI-PROJECT-24591434, KAKENHI-PROJECT-26861319
[Journal Article] Transplantation of allogenic fetal membrane-derived mesenchymal stem cells protect against ischemia-reperfusion-induced acute kidney injury.2013
- Author(s)
  Tsuda H, Yamahara K, Otani K, Okumi M, Yazawa K, Kaimori JY, Taguchi A, Kangawa K, Ikeda T, Takahara S, Isaka Y.
- Journal Title
  
  Cell transplantation
  
  Volume: in press Issue: 7 Pages: 889-899
- DOI
  10.3727/096368913x665594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390145
[Journal Article] Human umbilical cord provides a significant source of unexpanded mesenchymal stromal cells2012
- Author(s)
  Kikuchi-Taura A, Taguchi A, Ogawa H, et al.(13人中12人)
- Journal Title
  
  Cytotherapy
  
  Volume: 14 Issue: 4 Pages: 441-450
- DOI
  10.3109/14653249.2012.658911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591252, KAKENHI-PROJECT-23390145, KAKENHI-PROJECT-24591434
[Journal Article] Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis.2012
- Author(s)
  Ohshima M, Yamahara K, Ishikane S, Harada K, Tsuda H, Otani K, Taguchi A, Miyazato M, Katsuragi S, Yoshimatsu J, Kodama M, Kangawa K, Ikeda T.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 53(3) Issue: 3 Pages: 420-428
- DOI
  10.1016/j.yjmcc.2012.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390145, KAKENHI-PROJECT-23700569
[Journal Article] Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers.2011
- Author(s)
  Harada K, Yamahara K, Ohnishi S, Otani K, Kanoh H, Ishibashi-Ueda H, Minamino N, Kangawa K, Nagaya N, Ikeda T.
- Journal Title
  
  RegulPept.
  
  Volume: 168 Pages: 21-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] of microRNA-145 in human embryonic stem cell differentiation into vascu2011
- Author(s)
  Shintaro Y, Yamahara K, et al
- Journal Title
  
  Atherosclerosis
  
  Volume: 219 Pages: 468-474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390265
[Journal Article] The role of microRNA-145 in human embryonic stem cell differentiation into vascular cells2011
- Author(s)
  Yamaguchi S、Yamahara K et al、
- Journal Title
  
  Atherosclerosis
  
  Volume: 219(2) Pages: 468-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390265
[Journal Article] Adrenomedullin reduces expression of adhesion molecules on lymphatic endothelial cells.2011
- Author(s)
  Jin D, Otani K, Yamahara K, Ikeda T, Nagaya N, Kangawa K.
- Journal Title
  
  RegulPept.
  
  Volume: 166 Pages: 21-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] 血管平滑筋分化とマイクロRNA2011
- Author(s)
  山原研一, ほか
- Journal Title
  
  血管医学
  
  Volume: 12巻3号 Pages: 33-37
- Data Source
  KAKENHI-PROJECT-22390265
[Journal Article] Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.2010
- Author(s)
  Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T.
- Journal Title
  
  J Mol Cell Cardiol. 49(5)
  
  Pages: 753-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis.2010
- Author(s)
  Tsuda H, Yamahara K, Ishikane S, Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hosoda H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 299 Pages: 1004-1013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis2010
- Author(s)
  Tsuda H, Yamahara K, Ishikane S, Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hododa H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T.
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 299 Pages: 1004-1013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591028
[Journal Article] Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.2010
- Author(s)
  Ishikane S, Yamahara K, Sada M, Harada K, Kodama M, Ishibashi-Ueda H, Hayakawa K, Mishima K, Iwasaki K, Fujiwara M, Kangawa K, Ikeda T.
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 49 Pages: 753-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Allogenic fetal membrane-derived mesenchymal stem cells contribute to renal repair in experimental glomerulonephritis.2010
- Author(s)
  Tsuda H, Yamahara K, Ishikane S.Otani K, Nakamura A, Sawai K, Ichimaru N, Sada M, Taguchi A, Hosoda H, Tsuji M, Kawachi H, Horio M, Isaka Y, Kangawa K, Takahara S, Ikeda T.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: 299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591028
[Journal Article] Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells.2010
- Author(s)
  Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K.
- Journal Title
  
  Atherosclerosis. 212(1)
  
  Pages: 42-7
- NAID
  120002598375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells.2010
- Author(s)
  Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 212 Pages: 42-47
- NAID
  120002598375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Angiogenic properties of sustained release platelet-rich plasma: characterization in-vitro and in the ischemic hind limb of the mouse.2009
- Author(s)
  Bir SC, Esaki J, Marui A, Yamahara K, Tsubota H, Ikeda T, Sakata R.
- Journal Title
  
  J Vasc Surg. 50(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Potential use of endothelial progenitor cells for regeneration of the vasculature.2009
- Author(s)
  Yamahara K, Itoh H.
- Journal Title
  
  Ther Adv Cardiovasc Dis 3(1)
  
  Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases.2009
- Author(s)
  Park K, Itoh H, Yamahara K, Sone M, Miyashita K, Oyamada N, Sawada N, Taura D, Inuzuka M, Sonoyama T, Tsujimoto H, Fukunaga Y, Tamura N, Nakao K.
- Journal Title
  
  Endocrinology. 149
  
  Pages: 483-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Pathological role of angiostatin in heart failure: an endogenous inhibitor of mesenchymal stem-cell activation.2009
- Author(s)
  Yamahara K, Min KD, Tomoike H, Kangawa K, Kitamura S, Nagaya N
- Journal Title
  
  Heart 95(4)
  
  Pages: 283-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides.2009
- Author(s)
  Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29(10)
  
  Pages: 1516-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Pathological role of angiostatin in heart failure : an endogenous inhibitor of mesenchymal stem-cell activation.2009
- Author(s)
  Yamahara K, Min KD, Tomoike H, Kangawa K, Kitamura S, Nagaya N.
- Journal Title
  
  Heart. 95(4)
  
  Pages: 283-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Potential use of endothelial progenitor cells for regeneration of the vasculature.2009
- Author(s)
  Yamahara K, Itoh H
- Journal Title
  
  Ther Adv Cardiovasc Dis 58
  
  Pages: 2880-2892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790757
[Journal Article] Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells.2008
- Author(s)
  Nakanishi C, Yamagishi M, Yamahara K, Hagino I, Mori H, Sawa Y, Yagihara T, Kitamura S, Nagaya N
- Journal Title
  
  Biochem Biophys Res Commun 12 ; 374(1)
  
  Pages: 11-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Augmentatio of neovascularizaiton in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells2008
- Author(s)
  Yamahara K, et. al.
- Journal Title
  
  PLoS One 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart.2008
- Author(s)
  Takahashi K, Fukushima S, Yamahara K, Yashiro K, Shintani Y, Coppen SR, Salem HK, Brouilette SW, Yacoub MH, Suzuki K
- Journal Title
  
  Circulation 118(14 Suppl)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema.2008
- Author(s)
  Jin D, Harada K, Ohnishi S, Yamahara K, Kangawa K, Nagaya N
- Journal Title
  
  Cardiovasc Res 80(3)
  
  Pages: 324-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases.2008
- Author(s)
  Park K, Itoh H, Yamahara K, Sone M, Miyashita K, Oyamada N, Sawada N, Taura D, Inuzuka M, Sonoyama T, Tsujimoto H, Fukunaga Y, Tamura N, Nakao K
- Journal Title
  
  Endocrinology 149(2)
  
  Pages: 483-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema.2008
- Author(s)
  Jin D, Harada K, Ohnishi S, Yamahara K, Kangawa K, Nagaya N.
- Journal Title
  
  Cardiovasc Res. 80
  
  Pages: 339-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases.2008
- Author(s)
  Park K, Itoh H, Yamahara K, et. al.
- Journal Title
  
  Endocrinology 149
  
  Pages: 483-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Journal Article] Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration2007
- Author(s)
  Sone M, Itoh H, Yamahara K, et. al.
- Journal Title
  
  Arterioscler Tbromb Vasc Biol. 27
  
  Pages: 2127-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790656
[Patent] 血管新生を誘導する細胞集団の製造方法2023
- Inventor(s)
  山原研一他
- Industrial Property Rights Holder
  山原研一他
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-22K09221
[Patent] 血管新生を誘導する細胞集団の製造方法2022
- Inventor(s)
  山原研一他
- Industrial Property Rights Holder
  兵庫医科大学、株式会社シーテックス
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-154854
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K09221
[Patent] 羊膜間葉系細胞組成物の製造方法及び凍結保存方法、並びに治療剤2014
- Inventor(s)
  山原研一、田口明彦、相馬俊裕、大西俊介、小林明
- Industrial Property Rights Holder
  山原研一、田口明彦、相馬俊裕、大西俊介、小林明
- Industrial Property Rights Type
  特許
- Filing Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-23390145
[Presentation] フィーダー細胞OP9を用いた効率的M2マクロファージ・Angiogenesisーinducing cells（AiC）の誘導2024
- Author(s)
  山原研一、武田由紀、高木俊範、藏本要二、土居亜紀子、土江伸誉、相馬俊裕、松山知弘、中込隆之、吉村紳一
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K09221
[Presentation] OP9 共培養による臍帯血の血管新生特性変化と脳梗塞モデルへの移植による治療効果の検討2023
- Author(s)
  山原　研一
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K09221
[Presentation] フィーダー細胞 OP9 を用いた血管新生を誘導する血球系細胞の樹立2023
- Author(s)
  山原　研一
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K09221
[Presentation] 遺伝子発現イメージング法を用いた移植幹細胞の非侵襲的追跡法の開発．2014
- Author(s)
  大谷健太郎, 銭谷勉, 河嶋秀和, 福田肇, 橋川美子, 森口哲朗, 犬伏正幸, 飯田秀博, 山原研一
- Organizer
  第30回NCVC-RIカンファレンス
- Place of Presentation
  新大阪ワシントンホテルプラザ，大阪
- Data Source
  KAKENHI-PROJECT-22390239
[Presentation] 、microRNA-145 Prevents Intimal Hyperplasia in Rabbit Vein Graft Disease Model by Regulation of Smooth Muscle Cell Phenotype2013
- Author(s)
  Ohnaka M、Marui A、Yamahara K、Minakata K、Yamazaki K、Kumagai M、Masumoto H、IkedaT、Sakata R、Poster1
- Organizer
  The 21st Annual Meeting Of The Asian Society For Cardiovascular And Thoracic Surgery (ASCVTS2013)
- Place of Presentation
  Kobe、Japan
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] Noninvasive spatial and temporal tracking of multilayered cell sheet on infarcted heart using reporter gene imaging.2013
- Author(s)
  Otani K, Zeniya T, Kawashima H, Fukuda H, Hashikawa Y, Moriguchi T, Inubushi M, Iida H, Yamahara K.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas Convention Center, Dallas, USA
- Data Source
  KAKENHI-PROJECT-22390239
[Presentation] レポーター遺伝子とSPECTを用いた心筋梗塞モデルラットにおける移植細胞シートの機能定量イメージング．2013
- Author(s)
  銭谷勉、大谷健太郎、河嶋秀和、福田肇、橋川美子、森口哲朗、越野一博、堀祐樹、圓見純一郎、井口智史、山本明秀、山原研一、犬伏正幸、飯田秀博
- Organizer
  第8回日本分子イメージング学会総会・学術集会
- Place of Presentation
  横浜赤レンガ倉庫１号館，横浜
- Data Source
  KAKENHI-PROJECT-22390239
[Presentation] Noninvasive spatial and temporal tracking of multilayered cell sheet on infarcted heart using reporter gene imaging2013
- Author(s)
  Otani K, Zeniya T, Kawashima H, Fukuda H, Hashikawa Y, Moriguchi T, Inubushi M, Iida H, Yamahara K
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas Convention Center, Dallas, TX
- Data Source
  KAKENHI-PROJECT-22390239
[Presentation] Systemic Administration of Allogenic Fetal Membrane-derived MSC Ameliorates Experimental Autoimmune Myocarditis via Suppression of Th1/Th17 Immunity.2012
- Author(s)
  Kenichi Yamahara,
- Organizer
  American Heart Association 2012 Scientific Sessions. Circulation.
- Place of Presentation
  Los Angeles　USA
- Data Source
  KAKENHI-PROJECT-23390145
[Presentation] Systemic administration of allogenic fetal membrane-derived mesenchymal stem cells suppressed Th1 and Th17 T-cell immunity in experimental autoimmune myocarditis.2012
- Author(s)
  Kenichi Yamahara,
- Organizer
  European Society of Cardiology Congress 2012. European Heart Journal
- Place of Presentation
  Munich Germany
- Data Source
  KAKENHI-PROJECT-23390145
[Presentation] Intravenous administration of human CD34+ cord blood cells after neonatal stroke ameliorates brain damage in a mouse model.2012
- Author(s)
  Masahiro Tsuji, Akihiko Taguchi, Yukiko Kasahara, Makiko Ohshima, Kenichi Yamahara, Tomohiro Matsuyama, Tomoaki Ikeda.
- Organizer
  The 8th Hershey Conference on Developmental Brain Injury
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-24591617
[Presentation] 新生児脳梗塞モデルマウスに対するヒト臍帯血CD34陽性細胞静脈内投与の効果.2012
- Author(s)
  辻雅弘, 田口明彦, 笠原由紀子, 大嶌麻妃子, 山原研一, 池田智明, 松山知弘.
- Organizer
  第11回日本再生医療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591617
[Presentation] Impact of MicroRNA - 145 to prevent vein graft disease in rabbit by regulation of smooth muscle cell phenotype2012
- Author(s)
  Ohnaka M、Marui A、Yamahara K、 Ikeda Tet al
- Organizer
  American Heart Association 、 Scientific Sessions 2012 (AHA 84th)
- Place of Presentation
  Los Angeles、USA、
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] ヒトES細胞由来血管構成細胞におけるmicroRNA 145の役割2011
- Author(s)
  山原研一, ほか
- Organizer
  第11回日本抗加齢医学会総会
- Place of Presentation
  京都市(国立京都国際会館)
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] The role of microRNA-145 in the differentiation of human embryonic stem cells into smooth muscle cells2011
- Author(s)
  K.Yamahara, et al
- Organizer
  欧州心臓病学会2011
- Place of Presentation
  仏・パリ
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] ヒトES細胞由来血管平滑筋細胞の分化誘導におけるmiR-145の役割2010
- Author(s)
  山原研一, ほか
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] The role of Microrna-145 in human embryonic stem cell differentiation into smooth muscle cells2010
- Author(s)
  K Yamahara, et al
- Organizer
  米国心臓病学会2010
- Place of Presentation
  米国・シカゴ
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22390265
[Presentation] The Role of Microrna-145 in Human Embryonic Stem Cell Differentiation Into Smooth Muscle Cells2010
- Author(s)
  Yamaguchi S, Yamahara K, Homma K, Takesue S, Itoh H.
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  シカゴ、米国
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] ヒトES細胞由来血管平滑筋細胞の分化誘導におけるmiR-145の役割2010
- Author(s)
  山口慎太郎、山原研一、本間康一郎、武末園子、伊藤裕
- Organizer
  日本高血圧学会
- Place of Presentation
  福岡
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] Aging of human ES cell-derived vascular cells: analysis of early and late passage cells.2010
- Author(s)
  Yamahara K, Nishi T, Homma K, Takesue S, Yamaguchi S, Sone M, Itoh H.
- Organizer
  XX World Congress of the International Society for Heart Research (ISHR)
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] ES・iPS細胞を用いた血管細胞分化・老化研究2010
- Author(s)
  山原研一
- Organizer
  第5回慶應臨床血管フォーラム
- Place of Presentation
  慶應義塾大学総合医科学研究センター
- Year and Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] iPS細胞由来血管前駆細胞を用いた新規下肢動脈閉塞性疾患治療法の開発2009
- Author(s)
  山原研一
- Organizer
  第50回日本脈管学会共催シンポジウム
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] iPS細胞由来血管前駆細胞を用いた新規下肢動脈閉塞性疾患治療法の開発2009
- Author(s)
  山原研一
- Organizer
  第50回日本脈管学会
- Place of Presentation
  ハイアットリージェンシー東京
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21790757
[Presentation] 内因性ANP、BNPの血管新生、血管形成における役割2008
- Author(s)
  徳留健、岸本一郎、山原研一、堀尾武史、澤井一智、宮里幹也、河野雄平、佐田政隆、河野雅和、中尾一和、寒川賢治
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] アドレノメデュリンによるリンパ管再生作用とそのリンパ浮腫治療効果2008
- Author(s)
  金東浩、山原研一、原田和彦、大谷健太郎、永谷憲歳、寒川賢治
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  熊本
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] Adrenomedullin Induces Lymphangiogenesis and Ameriolates Secondary Lymphedema.2008
- Author(s)
  DongHao Jin, Kenichi Yamahara, Kazuhiko Harada, Shunsuke Ohnishi, Kenji Kangawa, Noritoshi Nagaya
- Organizer
  American Heart Association Scientific Session 2008
- Place of Presentation
  ニューオリンズ、米国
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] メタボリックシンドロームにおける脂肪細胞と血管内皮細胞の相互作用-アドレノメデュリンの役割2008
- Author(s)
  山原研一、永谷憲歳、寒川賢治
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] 重症心不全患者における間葉系幹細胞活性化抑制因子の探索2008
- Author(s)
  山原研一、永谷憲歳、北村惣一郎、寒川賢治
- Organizer
  第12回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] 間葉系幹細胞の心臓内幹細胞に対するパラクライン効果の検討2007
- Author(s)
  中西千明、山岸正和、山原研一、永谷憲歳
- Organizer
  第11回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] メタボリックシンドロームにおける脂肪組織血管内皮機能障害一共培養系における検討2007
- Author(s)
  山原研一, 他
- Organizer
  日本心血管内分泌代謝学会
- Place of Presentation
  東京コンファレンスセンター(品川)
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] 褥瘡に対するアドレノメデュリンの効果2007
- Author(s)
  原田和彦、大西俊介、山原研一、池田智明、藤原道弘、北村惣一郎、寒川賢治、永谷憲歳
- Organizer
  第11回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] メタボリックシンドロームにおける脂肪細胞血管内皮機能障害-共培養系における検討2007
- Author(s)
  山原研一、大西俊介、永谷憲歳
- Organizer
  第11回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京
- Year and Date
  2007-11-16
- Data Source
  KAKENHI-PROJECT-19790656
[Presentation] Intravenous administration of umbilical cord blood CD34+ cells ameliorates brain injury in a mouse model of neonatal stroke
- Author(s)
  Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T
- Organizer
  The 11th Asian Society for Pediatric Research
- Place of Presentation
  Osaka, Japan
- Year and Date
  2015-04-15 – 2015-04-18
- Data Source
  KAKENHI-PROJECT-24591617

1. OTANI Kentaro (50470191)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. INUBUSHI Masayuki (70399830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. MARUI Akira (60402856)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. Yoshimura Shinichi (40240353)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. 藏本要二 (10604275)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MATSUYAMA Tomohiro (10219529)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SAKATA Ryuzo (20325781)

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8. 曽根正勝 (40437207)

# of Collaborated Projects: 2 results

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9. 中込隆之 (80434950)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. ISAKA Yoshitaka (00379166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. TAKAHARA Shiro (70179547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. ITOH Hiroshi (40252457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
13. SAGA Tsuneo (40273445)

# of Collaborated Projects: 1 results

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14. KOIZUMI Mitsuru (20136352)

# of Collaborated Projects: 1 results

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15. JIN Yong-nan (50568285)

# of Collaborated Projects: 1 results

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16. LI Xiao-kang (60321890)

# of Collaborated Projects: 1 results

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17. HATAYAMA Naoyuki (80534792)

# of Collaborated Projects: 1 results

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18. MINAKATA Kenji (60539675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. IKEDA Tadashi (40281092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. TABATA Yasuhiko (50211371)

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21. IKEDA TOMOAKI (80202894)

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22. TSUJI MASAHIRO (80579467)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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24. IIDA Hidehiro (30322720)

# of Collaborated Projects: 1 results

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25. ENMI Junichiro (80393205)

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26. HAYAKAWA Masahiro (40343206)

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27. SATO Yoshiaki (30435862)

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28. MISHIMA Kenichi (00320309)

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38. 石兼真 (40470190)

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40. 恒吉裕史 (40645412)

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43. 道川祐市 (20360688)

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47. 白川学 (50425112)

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48. 藤田貢 (40609997)

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# of Collaborated Products: 0 results
49. HOMMA Koichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
50. TAKEUCHI Yasuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. XU Hua

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. SAITO Yoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. KURAMOTO YOJI

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
54. 松山知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
55. 猪原匡史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 小川啓恭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamahara Kenichi 山原 研一

山原 研一 ヤマハラ ケンイチ

YAMAHARA Kenichi 山原 研一

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骨髄由来血管新生誘導細胞を用いた脳梗塞後遺症に対する細胞治療研究Principal Investigator

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Cell therapy research using human umbilical cord blood-derived hemangioblast-like cells for the treatment of cerebral infarctionPrincipal Investigator

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Modulation of autophagic cell death to develop a new therapy for cardiovascular diseasesPrincipal Investigator

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Development of new vascular regenerative therapy by replacement of bone marrow cells with pluripotent stem cell-derived vascular progenitor cells.Principal Investigator

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Yamahara Kenichi 山原研一

山原研一ヤマハラケンイチ

YAMAHARA Kenichi 山原研一