Kubo Akiko 久保亜紀子

… Alternative Names

AKIKO Kubo 久保亜紀子

KUBO Akiko 久保亜希子

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Researcher Number	50455573
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 特命講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 神戸大学, 医学研究科, 特命講師 2018 – 2022: 慶應義塾大学, 医学部(信濃町), 助教 2017 – 2018: 慶應義塾大学, 医学部(信濃町), 特任助教 2017: 慶應義塾大学, 医学部(信濃町), 共同研究員 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 特任講師 … More 2016: 慶應義塾大学, 医学部, 特任講師 2015: 慶應義塾大学, 医学部, 講師 2014: 慶應義塾大学, 医学部, 特任講師 2013: 慶應義塾大学, 医学部, 特任講師(非常勤) 2007 – 2008: Mitsubishi Kagaku Institute of Life Sciences, 研究部門・分子加齢医学研究グループ, 特別研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Basic Section 49010:Pathological biochemistry-related / Genome biology / オミクス計測科学 / Experimental pathology Except Principal Investigator Basic Section 53050:Dermatology-related / Pathological medical chemistry / Basic Section 90140:Medical technology assessment-related / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related … More / Basic Section 46030:Function of nervous system-related / Parasitology (including sanitary zoology) / Medium-sized Section 50:Oncology and related fields / Genome biology / Kidney internal medicine / Dermatology / Anesthesiology/Resuscitation studies / Genome biology Less
Keywords	Principal Investigator メタボロミクス / 糖尿病性腎症 / イメージング質量分析 / 質量分析イメージング / 代謝変動 / ストレプトゾトシン / 糖尿病 / アミノ酸代謝 / I型糖尿病性腎症発症モデル / 代謝解析 … More / I型糖尿病 / 栄養学 / 質量分析 / メタボローム / 代謝 / エピジェネティクス / プロテオーム / 神経科学 / 老化 / 病理学 / 脳神経疾患 … More Except Principal Investigator 代謝 / 低酸素 / 質量分析イメージング / 低酸素応答 / ミトコンドリア / メタボロミクス / NSDHL / コレステロール合成 / CHILD症候群 / ケブネル現象 / エネルギー代謝 / PHD / HIF / クローン性増殖 / エピゲノム変異 / 汗孔角化症 / モザイク疾患 / 細胞競合 / がん層別化 / リキッドバイオプシー / モザイク / セカンドヒット / 血管腫 / 悪性黒色種 / ストレプトゾトシン / 糖尿病 / アミノ酸 / 身体能力 / 間欠絶食 / ヒストンアセチル化 / エピゲノム / BCAA / サルコペニア / 免疫チェックポイント阻害薬 / 免疫抑制 / 脂質代謝 / がん遺伝子 / がん微小環境 / cerebral ischemia / microcirculation / molecular hydrogen / metabolism / stroke / Neurovascular coupling / Neurovascular unit / 脳虚血 / 分子状水素 / メタボライト / 植物ホルモン / 休眠 / 原虫 / マラリア / 固形腫瘍 / 免疫 / 腫瘍血管 / mitochondria / respiratory chain / interferon-gamma / mTORC1 / p62 / Nrf2 / がん細胞 / IFNg / 腫瘍浸潤CD8T細胞 / IFNγ / Glut-1 / NRF2 / CD8TIL / 活性酸素 / 酸化的リン酸化 / 解糖系 / インターフェロンγ / CD8T細胞 / 腫瘍微小環境 / CD1a / 乾癬様皮膚炎 / モデルマウス / コレステロール代謝物 / CHILD症候群モデルマウス / 乾癬様皮疹 / 皮膚炎 / プロテオミクス / 代謝生化学 / プロリン水酸化酵素 / 阻害薬 / HIF-PH / プロリン / 水酸化 / 老化 / 細胞周期 / 癌化 / 不死化 / 細胞老化 / 腎虚血 / 急性腎不全 / 代謝産物可視化 / 腎臓 / ATP / アデノシン / コレステロール代謝 / 虚血再灌流障害 / 心肺蘇生 / 心停止 / Cori回路 / PHD2 / 心筋梗塞 / メタボローム解析 / 虚血再灌流 / メタボローム / 虚血再灌流傷害 / iscemia / metabolomics / hypoxia Less

角層天然保湿因子の質量分析イメージング解析による魚鱗癬の病態解明と治療評価Principal Investigator
- Principal Investigator
  
  久保亜紀子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
一次繊毛のエピゲノム制御に着目した悪性黒色腫のBRAF阻害剤耐性獲得機序の解明
- Principal Investigator
  
  福本毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
多発血管腫に着目した皮膚血管内皮「セカンドヒット病」の探索と新規原因遺伝子の同定
- Principal Investigator
  
  小野竜輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
がん細胞の脂肪酸代謝特性を活用した高精度がん早期診断モデルの構築と社会実装
- Principal Investigator
  
  加藤果野子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90140:Medical technology assessment-related
- Research Institution
  Nihon University
Understanding the mechanism of cell competition and clonal expansion in porokeratosis to develop novel therapeutics
- Principal Investigator
  
  久保亮治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
Elucidation of the mechanism of diabetic nephropathy pathogenesis and development of preventive methods focusing on the metabolism of branched-chain amino acids during hyperglycaemia.Principal Investigator
- Principal Investigator
  
  Kubo Akiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kobe University
  Keio University
Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.
- Principal Investigator
  
  Miyashita Kazutoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
Elucidation and control of immunosuppressive mechanisms by oncogenes and abnormal lipid metabolism in the tumor microenvironment
- Principal Investigator
  
  Kawakami Yutaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  International University of Health and Welfare
  Keio University
Effects of molecular hydrogen on ischemic brain injury
- Principal Investigator
  
  Kajimura Mayumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Keio University
Mechanism of lipid antigen presentation via CD1a and induction of skin inflammation
- Principal Investigator
  
  Arao Noriko
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Tokyo Women's Medical University
  Keio University
Metabolism-based dissection of tumor microenvironment infiltrated by immune cells
- Principal Investigator
  
  UDONO Heiichiro
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Okayama University
Visualization of small metabolites in the kidney for elucidation of pathophysiology of ischemic nephropathy
- Principal Investigator
  
  Itoh Hiroshi
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
In vivo metabolomic analysis and metabolic alteration-targeted treatment on diabetic nephropathy model .Principal Investigator
- Principal Investigator
  
  KUBO Akiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  Keio University
Elucidation of the regulatory mechanism of metabolism in response to hypoxia by hydroxylation omics analysis
- Principal Investigator
  
  Minamishima Yoji Andrew
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Gunma University
  Kyushu University
Mechanism of Koebner phenomenon in CHILD syndrome
- Principal Investigator
  
  Umegaki Noriko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Deciphering hypnozoite formation of Plasmodium vivax
- Principal Investigator
  
  KANEKO Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Nagasaki University
Identification of the specific metabolic system for cellular senescence and tumorigenesis
- Principal Investigator
  
  Minamishima Yoji Andrew
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
  Keio University
Analysis of epigenetic regulation by visualizing S-adenosylmethionine metabolism in cancer cells using imaging mass spectrometry.Principal Investigator
- Principal Investigator
  
  Kubo Akiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  オミクス計測科学
- Research Institution
  Keio University
Elucidation of activating Cori cycle caused by inhibition of PHD2 in liver
- Principal Investigator
  
  KASAHARA Masataka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Hypoxic response as a new treatment of Post cardiac arrest syndrome
- Principal Investigator
  
  MINAMISHIMA Shizuka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Keio University
New concept for treatment of iscgemia/reperfusion injuries brought by metabolomics
- Principal Investigator
  
  MINAMISHIMA Yoji Andrew
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genome biology
- Research Institution
  Keio University
Analyses of the TUBG2 deficient mouse showing Parkinsonian like behaviorPrincipal Investigator
- Principal Investigator
  
  KUBO Akiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Experimental pathology
- Research Institution
  Mitsubishi Kagaku Institute of Life Sciences

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All Journal Article Presentation Book Patent

[Book] 腎臓内科・泌尿器科2015
- Author(s)
  南嶋洋司、久保亜紀子
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26670163
[Journal Article] Histological analysis of psoriasiform eruption associated with myelin oligodendrocyte glycoprotein antibody-associated disease2024
- Author(s)
  Itoi-Ochi Saori、Kurosaki Yukiho、Ota Asako、Miyazaki Akiko、Hosokawa Akiko、Nakano Misa、Takahashi Toshiyuki、Umegaki-Arao Noriko、Fujimoto Manabu
- Journal Title
  
  JAAD Case Reports
  
  Volume: 46 Pages: 1-4
- DOI
  10.1016/j.jdcr.2023.12.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08310
[Journal Article] 角化症の遺伝学的モザイク2024
- Author(s)
  久保亮治
- Journal Title
  
  皮膚科
  
  Volume: 4 Pages: 138-145
- Data Source
  KAKENHI-PROJECT-23K27622
[Journal Article] Gene-specific somatic epigenetic mosaicism of FDFT1 underlies a non-hereditary localized form of porokeratosis2024
- Author(s)
  Saito S, Saito Y, Sato S, Aoki S, Fujita H, Ito Y, Ono N, Funakoshi T, Kawai T, Suzuki H, Sasaki T, Tanaka T, Inoie M, Hata K, Kataoka K, Kosaki K, Amagai M, Nakabayashi K, Kubo A
- Journal Title
  
  American Journal of Human Genetics
  
  Volume: 111 Issue: 5 Pages: 896-912
- DOI
  10.1016/j.ajhg.2024.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27622
[Journal Article] こどもによくみられる遺伝性皮膚疾患2023
- Author(s)
  小野紀子，久保亮治
- Journal Title
  
  MB Derma
  
  Volume: 334 Pages: 93-103
- Data Source
  KAKENHI-PROJECT-23K27622
[Journal Article] CD8+ T-cell responses are boosted by dual PD-1/VEGFR2 blockade after EGFR inhibition in Egfrmutant lung cancer.2022
- Author(s)
  Nishii K, Ohashi K, Tomida S, Nakasuka T, Hirabae A,Okawa S, Nishimura J, Higo H, Watanabe H, Kano H, Ando C, Makimoto G, Ninomiya K, Kato Y, Kubo T, Ichihara E, Hotta K, Tabata M, Toyooka S, Udono H, Maeda Y, Kiura K.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 10 Issue: 9 Pages: 1111-1126
- DOI
  10.1158/2326-6066.cir-21-0751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19409, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-18H04033, KAKENHI-PROJECT-19H03667, KAKENHI-PROJECT-20H03771, KAKENHI-PROJECT-23K24339
[Journal Article] Superimposition of checkerboard distribution of ephelides and neurofibromas in a patient with segmental neurofibromatosis2022
- Author(s)
  Iriki Hisato、Umegaki-Arao Noriko、Kakuta Risa、Fujita Harumi、Aoki Satomi、Amagai Masayuki、Sasaki Takashi、Hamamoto Yasuo、Nakayama Robert、Kubo Akiharu
- Journal Title
  
  JAAD Case Reports
  
  Volume: 25 Pages: 89-92
- DOI
  10.1016/j.jdcr.2022.05.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08310
[Journal Article] Palmar whitish change after water exposure in a familial mild case of loricrin keratoderma (loricrin ichthyosis)2022
- Author(s)
  Saito Sonoko、Tanaka Ryo、Ono Noriko、Umegaki‐Arao Noriko、Sasaki Takashi、Aoki Satomi、Amagai Masayuki、Kubo Akiharu
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 49 Issue: 11
- DOI
  10.1111/1346-8138.16481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08310
[Journal Article] Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody2022
- Author(s)
  Yuki Katoh, Tomonori Yaguchi, Akiko Kubo, Takashi Iwata, Kenji Morii, Daiki Kato, Shigeki Ohta, Ryosuke Satomi, Yasuhiro Yamamoto, Yoshitaka Oyamada, Kota Ouchi, Shin Takahashi, Chikashi Ishioka, Ryo Matoba, Makoto Suematsu, Yutaka Kawakami
- Journal Title
  
  J Immunotherapy Cancer
  
  Volume: 10(7) Issue: 7 Pages: e004616-e004616
- DOI
  10.1136/jitc-2022-004616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07199, KAKENHI-PROJECT-21K15602, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H03534, KAKENHI-PROJECT-21H02785
[Journal Article] Guidelines for clinical evaluation of anti‐cancer drugs2021
- Author(s)
  Minami Hironobu、Kiyota Naomi、Kimbara Shiro、Ando Yuichi、Shimokata Tomoya、Ohtsu Atsushi、Fuse Nozomu、Kuboki Yasutoshi、Shimizu Toshio、Yamamoto Noboru、Nishio Kazuto、Kawakami Yutaka、Nihira Shin‐ichi、Sase Kazuhiro、Nonaka Takahiro、Takahashi Hideaki、Komori Yukiko、Kiyohara Koshin
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 7 Pages: 2563-2577
- DOI
  10.1111/cas.14967
- NAID
  120007169038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K12134, KAKENHI-PROJECT-20H03534
[Journal Article] Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study)2021
- Author(s)
  Yamazaki Naoya、Takenouchi Tatsuya、Nakamura Yasuhiro、Takahashi Akira、Namikawa Kenjiro、Kitano Shigehisa、Fujita Tomonobu、Kubota Kazumi、Yamanaka Takeharu、Kawakami Yutaka
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 51 Issue: 8 Pages: 1232-1241
- DOI
  10.1093/jjco/hyab064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03534
[Journal Article] DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation2021
- Author(s)
  Akihito Hishikawa, Kaori Hayashi (corresponding author), Akiko Kubo, Kazutoshi Miyashita, Akinori Hashiguchi, Kenichiro Kinouchi, Norifumi Yoshimoto, Ran Nakamichi, Riki Akashio, Erina Sugita, Tatsuhiko Azegami, Toshiaki Monkawa, Makoto Suematsu, Hiroshi Itoh.
- Journal Title
  
  iScience.
  
  Volume: 24(12) Issue: 12 Pages: 103436-103436
- DOI
  10.1016/j.isci.2021.103436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08688, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-21K06876, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K17291
[Journal Article] Eosinophilic pustular folliculitis with palmoplantar lesions and nail deformity2020
- Author(s)
  Umegaki‐Arao Noriko、Tanemoto Sae、Tanese Keiji、Kubo Akiharu、Takahashi Hayato、Kurihara Yuichi、Yanagisawa Erika、Kameyama Kaori、Amagai Masayuki、Saito Masataka
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Issue: 10
- DOI
  10.1111/1346-8138.15503
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08310
[Journal Article] Successful treatment with secukinumab of three psoriatic patients undergoing dialysis2019
- Author(s)
  Mukai Miho、Kurihara Yuichi、Ito Yoshihiro、Shintani Yuka、Takahashi Hayato、Kubo Akiharu、Amagai Masayuki、Umegaki‐Arao Noriko
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Issue: 1
- DOI
  10.1111/1346-8138.15132
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08310
[Journal Article] A nonepidermolytic keratinocytic epidermal naevus associated with a postzygotic mutation in the gene encoding epidermal growth factor receptor2019
- Author(s)
  Umegaki‐Arao N.、Ono N.、Tanaka R.、Sasaki T.、Fujita H.、Shiohama A.、Aoki S.、Amagai M.、Kubo A.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: - Issue: 5 Pages: 1303-1305
- DOI
  10.1111/bjd.18729
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10252, KAKENHI-PROJECT-18K08310
[Journal Article] Clonal Expansion of Second-Hit Cells with Somatic Recombinations or C>T Transitions Form Porokeratosis in MVD or MVK Mutant Heterozygotes2019
- Author(s)
  Kubo Akiharu、Sasaki Takashi、Suzuki Hisato、Shiohama Aiko、Aoki Satomi、Sato Showbu、Fujita Harumi、Ono Noriko、Umegaki-Arao Noriko、Kawai Tomoko、Nakabayashi Kazuhiko、Hata Kenichiro、Yamada Daisuke、Matsubara Yoichi、Kosaki Kenjiro、Amagai Masayuki
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 139 Issue: 12 Pages: 2458-2466.e9
- DOI
  10.1016/j.jid.2019.05.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08310, KAKENHI-PROJECT-17K10252
[Journal Article] Unique clinical and serological features of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors2018
- Author(s)
  Horikawa H.、Kurihara Y.、Funakoshi T.、Umegaki-Arao N.、Takahashi H.、Kubo A.、Tanikawa A.、Kodani N.、Minami Y.、Meguro S.、Itoh H.、Izumi K.、Nishie W.、Shimizu H.、Amagai M.、Yamagami J.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: * Issue: 6 Pages: 1462-1463
- DOI
  10.1111/bjd.16479
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] A familial case of nail patella syndrome with a heterozygous in-frame indel mutation in the LIM domain of LMX1B2018
- Author(s)
  Mukai Miho、Fujita Harumi、Umegaki-Arao Noriko、Sasaki Takashi、Yasuda-Sekiguchi Fumiyo、Isojima Tsuyoshi、Kitanaka Sachiko、Amagai Masayuki、Kubo Akiharu
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 90 Issue: 1 Pages: 90-93
- DOI
  10.1016/j.jdermsci.2017.12.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07887, KAKENHI-PROJECT-16K09985, KAKENHI-PROJECT-15K09782
[Journal Article] Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors.2018
- Author(s)
  Kubo T, Ninomiya T, Hotta K, Kozuki T, Toyooka S, Okada H, Fujiwara T, Udono H, Kiura K.
- Journal Title
  
  Clin Lung Cancer.
  
  Volume: 19 Issue: 6 Pages: e861-e864
- DOI
  10.1016/j.cllc.2018.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19598, KAKENHI-PROJECT-18H04033, KAKENHI-PROJECT-15H04830
[Journal Article] Distinct phenotype of epidermolysis bullosa simplex with infantile migratory circinate erythema due to frameshift mutations in the V2 domain of KRT5.2017
- Author(s)
  Kumagai Y, Umegaki-Arao N, Sasaki T, Nakamura Y, Takahashi H, Ashida A, Tsunemi Y, Kawashima M, Shimizu A, Ishiko A, Nakamura K, Tsuchihashi H, Amagai M, Kubo A.
- Journal Title
  
  J Eur Acad Dermatol Venereol.
  
  Volume: May;31(5) Issue: 5
- DOI
  10.1111/jdv.14005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Somatic HRAS p.G12S mosaic mutation causes unilaterally distributed epidermal nevi, woolly hair and palmoplantar keratosis2017
- Author(s)
  Honda Aki、Umegaki-Arao Noriko、Sasaki Takashi、Nakabayashi Kazuhiko、Hata Kenichiro、Matsubara Yoichi、Tanikawa Akiko、Amagai Masayuki、Kubo Akiharu
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 44 Issue: 6
- DOI
  10.1111/1346-8138.13801
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Targeting oxygen sensing prolyl hydroxylase (PHD) for metformin-associated lactic acidosis treatment.2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 37 (16) Issue: 16
- DOI
  10.1128/mcb.00248-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01937, KAKENHI-PROJECT-16H04723, KAKENHI-PROJECT-16K07203
[Journal Article] Inflammatory Linear Verrucous Epidermal Nevus with a Postzygotic GJA1 Mutation Is a?Mosaic Erythrokeratodermia Variabilis et?Progressiva2017
- Author(s)
  Umegaki-Arao Noriko、Sasaki Takashi、Fujita Harumi、Aoki Satomi、Kameyama Kaori、Amagai Masayuki、Seishima Mariko、Kubo Akiharu
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 137 Issue: 4 Pages: 967-970
- DOI
  10.1016/j.jid.2016.11.016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Inflammatory Linear Verrucous Epidermal Nevus with a Postzygotic GJA1 Mutation Is a Mosaic Erythrokeratodermia Variabilis et Progressiva.2017
- Author(s)
  Umegaki-Arao N, Sasaki T, Fujita H, Aoki S, Kameyama K, Amagai M, Seishima M, Kubo A.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: Apr;137(4) Pages: 967-970
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Case of dominant dystrophic epidermolysis bullosa with amniotic band syndrome.2017
- Author(s)
  Sakiyama T, Umegaki-Arao N, Sasaki T, Kosaki K, Amagai M, Kubo A.
- Journal Title
  
  J Dermatol
  
  Volume: Jan;44(1) Issue: 1 Pages: 102-103
- DOI
  10.1111/1346-8138.13449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>A LIPH mutation.2017
- Author(s)
  Kinoshita-Ise M, Kubo A, Sasaki T, Umegaki-Arao N, Amagai M, Ohyama M.
- Journal Title
  
  Br J Dermatol.
  
  Volume: Jan;176(1) Issue: 1 Pages: 138-144
- DOI
  10.1111/bjd.14836
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] 質量分析イメージング2017
- Author(s)
  久保亜紀子
- Journal Title
  
  Medical Science Digest
  
  Volume: 43 Pages: 647-648
- Data Source
  KAKENHI-PROJECT-16K07203
[Journal Article] Case of lymphoplasmacytic plaque in children: Analysis of the distribution of infiltrating immune cells.2016
- Author(s)
  Mukai M, Tanese K, Umegaki-Arao N, Kubo A, Takahashi H, Amagai M.
- Journal Title
  
  J Dermatol.
  
  Volume: Nov;43(11) Issue: 11 Pages: 1368-1370
- DOI
  10.1111/1346-8138.13413
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Journal Article] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle2015
- Author(s)
  Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr., Suematsu M, Minamishima YA§. (§Corresponding author)
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 112 Issue: 37 Pages: 11642-7
- DOI
  10.1073/pnas.1515872112
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163, KAKENHI-PLANNED-26111006, KAKENHI-PROJECT-25513008
[Journal Article] Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia2015
- Author(s)
  2.Takenouchi T, Sugiura Y, Morikawa T, Nakanishi T, Nagahata Y, Sugioka T, Honda K, Kubo A, Hishiki T, Matsuura T, Hoshino T, Takahashi T, Suematsu M, and Kajimura M
- Journal Title
  
  Journal of Cerebral Blood Flow & Metabolism
  
  Volume: 35 Issue: 5 Pages: 1-12
- DOI
  10.1038/jcbfm.2014.253
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-25513008, KAKENHI-PLANNED-26111006, KAKENHI-PROJECT-26560469, KAKENHI-PROJECT-26860854
[Journal Article] Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays oftransparent boehmite,2015
- Author(s)
  1.Yamazoe S, Naya M, Shiota M, Morikawa M, Kubo A, Tani T, Hishiki T, Horiuchi T, Suematsu M, and Kajimura M
- Journal Title
  
  ACS Nano
  
  Volume: 8 Issue: 6 Pages: 5622-5632
- DOI
  10.1021/nn4065692
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500448, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.2014
- Author(s)
  Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H and Suematsu M
- Journal Title
  
  Nitric Oxide
  
  Volume: pii: S1089-8603 Pages: 495-499
- DOI
  10.1016/j.niox.2014.11.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-25870717, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-25513008
[Journal Article] Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway.2014
- Author(s)
  Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, Takako Hishiki, and Makoto Suematsu.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 3480-3480
- DOI
  10.1038/ncomms4480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Journal Article] 「持ちつ持たれつ・・・がんの代謝」―グルタミノリシス2014
- Author(s)
  久保亜紀子
- Journal Title
  
  実験医学増刊
  
  Volume: 32 Pages: 92-98
- Data Source
  KAKENHI-PROJECT-25513008
[Journal Article] Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts.2014
- Author(s)
  Toue S, Sugiura Y, Kubo A, Ohmura M, Karakawa S, Mizukoshi T, Yoneda J, Miyano H, Noguchi Y, Kobayshi T, Kabe Y, Suematsu M.
- Journal Title
  
  Proteomics
  
  Volume: 14 Issue: 7-8 Pages: 810-819
- DOI
  10.1002/pmic.201300041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570172, KAKENHI-PROJECT-25513008
[Journal Article] Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo.2013
- Author(s)
  Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA.
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 11 Issue: 9 Pages: 973-985
- DOI
  10.1158/1541-7786.mcr-12-0669-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310136, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-24651265, KAKENHI-PROJECT-25513008
[Patent] MALDI 用試料調製方法及び試料調製装置2015
- Inventor(s)
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Holder
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-510153
- Filing Date
  2015-10-02
- Overseas
- Data Source
  KAKENHI-PROJECT-25513008
[Patent] 分析データ表示処理装置及び表示処理プログラム2015
- Inventor(s)
  後藤信一　梶村眞弓　久保亜紀子　末松誠　池上将弘　緒方是嗣
- Industrial Property Rights Holder
  後藤信一　梶村眞弓　久保亜紀子　末松誠　池上将弘　緒方是嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-161543
- Filing Date
  2015-08-19
- Data Source
  KAKENHI-PROJECT-25513008
[Patent] MALDI 用試料調製方法及び試料調製装置2014
- Inventor(s)
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Holder
  緒方是嗣　高橋和輝　久保亜紀子　末松誠　山本卓志
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-04
- Data Source
  KAKENHI-PROJECT-25513008
[Patent] 質量分析を用いたアンモニア測定方法2013
- Inventor(s)
  久保亜紀子　末松誠　緒方是嗣
- Industrial Property Rights Holder
  久保亜紀子　末松誠　緒方是嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-209000
- Filing Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-25513008
[Patent] 多系統萎縮症治療薬のスクリーニング方法2008
- Inventor(s)
  久保亜紀子, 他2名
- Industrial Property Rights Holder
  三菱化学株式会社
- Industrial Property Number
  2008-299597
- Filing Date
  2008-11-25
- Data Source
  KAKENHI-PROJECT-19890283
[Presentation] 皮膚モザイク疾患から迫る多細胞生命自律性2023
- Author(s)
  久保亮治
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] スキンタッグはなぜできる？　身近な症状に潜む遺伝学的モザイク2023
- Author(s)
  久保亮治
- Organizer
  日本皮膚科学会東京支部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] 遺伝子から眺める皮膚科学　~身近な疾患から稀少疾患まで~2023
- Author(s)
  久保亮治
- Organizer
  日本小児皮膚科学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] 遺伝学的モザイクから考えるクローン性増殖疾患の皮膚科学2023
- Author(s)
  久保亮治
- Organizer
  日本皮膚悪性腫瘍学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] Genetic Mosaicism in the Pathogenesis of Common and Rare Skin Diseases2023
- Author(s)
  Akiharu Kubo
- Organizer
  Annual Autumn Meeting of the Korean Dermatology Association
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] 皮膚疾患・症状に見られるモザイクの考え方2023
- Author(s)
  久保亮治
- Organizer
  日本臨床皮膚科医会総会・臨床学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27622
[Presentation] A non-epidermolytic epidermal nevus associated with a postzygotic EGFR mutation.2023
- Author(s)
  Umegaki-Arao N, Ono N, Tanaka R, Sasaki T, Fujita H, Shiohama A, Amagai M, Kubo A.
- Organizer
  1st. International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 2023.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08310
[Presentation] Combination immunotherapy trageting stearoyl-CoA desaturase 1 (SCD1) with immunosuppressive activity2022
- Author(s)
  Yuki Katoh, Tomonori Yaguchi , Akiko Kubo ,Takashi Iwata , Kenji Morii , Daiki Kato, Shigeki Ohta , Makoto Suematsu , Yutaka Kawakami
- Organizer
  第51回日本免疫学術総会
- Data Source
  KAKENHI-PROJECT-20H03534
[Presentation] A SEMI-QUANTITAIVE IMAGING MASS SPECTROMETRY REVEALED THE RENO-PROTECTIVE EFFECT OF FEBUXOSTAT IN THE ISCHEMIC KIDNEY BY PROMOTING ATP RECOVERY IN THE CORTEX.2018
- Author(s)
  K. Fujii, K. Miyashita, A. Kubo, M. Sato, A. Hagiwara, H. Inoue, M. Suematsu, H. Itoh
- Organizer
  55th ERA-EDTA congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] 急性虚血性腎障害におけるフェブキスソタットによるATPブーストを介した腎保護メカニズムのマスイメージングを用いた可視化解析2018
- Author(s)
  藤井健太郎, 宮下和季, 久保亜紀子, 佐藤正明, 萩原あいか, 井上博之, 竜崎正毅, 末松誠, 伊藤裕
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] キサンチンオキシダーゼ阻害による虚血腎保護メカニズムのマスイメージングを用いた可視化解析2018
- Author(s)
  藤井健太郎, 宮下和季, 久保亜紀子, 佐藤正明, 萩原あいか, 井上博之, 竜崎正毅, 末松誠, 伊藤裕
- Organizer
  第91回日本内分泌学会総会
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] Febuxostat exerted reno-protective effects after transient ischemia by promoting ATP recovery in the cortex: visualization of renal adenine nucleotides by an imaging mass-spectrometry technique2018
- Author(s)
  K. Miyashita, K. Fujii, A. Kubo, M. Sato, A. Hagiwara, H. Inoue, M. Suematsu, H. Itoh
- Organizer
  27th Scientific Meeting of International Society of Hypertension,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] A mass imaging technique revealed a reno-protective effect of the xanthine oxidase inhibitor febuxostat in the ischemic kidney by promoting ATP recovery in the cortex2018
- Author(s)
  K. Miyashita, K. Fujii, A. Kubo, M. Sato, A. Hagiwara, H. Inoue, M. Suematsu, H. Itoh
- Organizer
  28th Scientific Meeting of European Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] A semi-quantitative mass imaging technique revealed region-specific alteration of adenylates in the murine kidney after transient ischemia and reno-protective effect of febuxostat by ameliorating ATP levels in the cortex.2018
- Author(s)
  藤井健太郎, 宮下和季, 久保亜紀子, 佐藤正明, 萩原あいか, 井上博之, 竜崎正毅, 末松誠, 伊藤裕
- Organizer
  第61回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] GJA1モザイク変異を同定したInflammatory linear verrucous epidermal nevusの世界第１例2017
- Author(s)
  梅垣知子、佐々木貴史、藤田春美、青木里美、亀山香織、天谷雅行、清島真理子、久保亮治
- Organizer
  第116回　日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-15K09782
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Azathioprine-induced anagen effluvium and leukopenia associated with NUDT15 polymorphisms2017
- Author(s)
  Hisashi Nomura, Yuichi Kurihara, Masataka Saito, Jun Yamagami Takeru Funakoshi, Masayuki Amagai, Noriko Umegaki-Arao, Akiharu Kubo
- Organizer
  第10回　国際毛髪科学研究会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Presentation] 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~2017
- Author(s)
  壽原朋宏*, 菱木貴子, 笠原正貴, 早川典代, 小柳津智子, 中西豪, 久保亜紀子, 末松誠, 南嶋洋司, 森崎浩
- Organizer
  第43回日本集中治療医学会学術集会
- Place of Presentation
  神戸国際展示場・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答による細胞内エネルギー代謝制御機構2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第17回日本高気圧環境・潜水医学会関東地方会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] LMX1B with an inframe indel mutation in a familial case of nail patella syndrome shows loss of its transcriptional activity2017
- Author(s)
  Miho Mukai, Harumi Fujita, Noriko Umegaki-Arao, Takashi Sasaki, Fumiyo Yasuda, Hayato Takahashi, Tsuyoshi Isojima, Sachiko Kitanaka, Masayuki Amagai, Akiharu Kubo,
- Organizer
  第42回　日本研究皮膚科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Presentation] The identification of a postzygotic GJA1 mutation in a patient with an inflammatory linear verrucous epidermal nevus suggests that the disease is a mosaic of erythrokeratodermia variabilis et progressiva2017
- Author(s)
  Noriko Umegaki-Arao, Takashi Sasaki, Harumi Fujita, Satomi Aoki, Masayuki Amagai, Mariko Seishima, Akiharu Kubo
- Organizer
  ESDR 2017 in Salzburg
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09782
[Presentation] Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール/長崎新聞文化ホール
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA)2017
- Author(s)
  Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Minamishima S, Kubo A, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA*
- Organizer
  Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”
- Place of Presentation
  Whistler Conference Centre , Whistler, BC, Canada
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 低酸素応答メカニズムを標的としたメトホルミン関連乳酸アシドーシス (MALA)の新規治療法の開発2017
- Author(s)
  小柳津-寅丸智子、壽原朋宏、早川典代、中村貴、南嶋しづか、久保亜紀子、山口京二、菱木貴子、森﨑浩、末松誠、南嶋洋司
- Organizer
  第60回日本糖尿病学会/第4回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04723
[Presentation] 質量分析イメージングによる腎皮髄境界におけるアデノシン集積の発見とアデノシン集積機構の解析2016
- Author(s)
  藤井健太郎, 宮下和季, 久保亜紀子, 佐藤正明, 萩原あいか, 井上博之, 末松誠, 伊藤裕
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] Dense accumulation of adenosine in the outer stripes of outer medulla in murine kidney identified by microscopic MALDI-imaging mass spectrometry2016
- Author(s)
  久保亜紀子・藤井健太郎・宮下和季・菱木貴子・伊藤　裕・末松　誠
- Organizer
  21st International Mass Spectrometry Conference
- Place of Presentation
  Toronto, canada
- Year and Date
  2016-08-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] Dense accumulation of adenosine in the outer stripes of outer medulla in murine kidney identified by microscopic MALDI-imaging mass spectrometry2016
- Author(s)
  Akiko Kubo, Kentaro Fujii, Kazutoshi Miyashita, Takako Hishiki, Hiroshi Itoh, Makoto Suematsu
- Organizer
  21st International Mass Spectrometry Conference 2016
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15471
[Presentation] ACCUMULATION OF ADENOSINE IN THE OUTER STRIPES OF OUTER MEDULLA IN MURINE KIDNEY IDENTIFIED BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION IMAGING MASS SPECTROMETRY.2016
- Author(s)
  K. Fujii, K. Miyashita, A. Kubo, M. Sato, A. Hagiwara, H. Inoue, M. Suematsu, H. Itoh
- Organizer
  26th Scientific Meeting of International Society of Hypertension,
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15471
[Presentation] 質量分析イメージングが解く腎アデニル酸代謝のパラドクス2016
- Author(s)
  久保亜紀子・藤井健太郎・中西　豪・宮下和季・伊藤　裕・末松　誠
- Organizer
  第64回質量分析総合討論会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] Analysis of renal adenine nucleotides with an imaging mass spectrometry and their alteration by acute ischemia2016
- Author(s)
  宮下和季, 藤井健太郎, 佐藤正明, 久保亜紀子, 末松誠, 伊藤裕
- Organizer
  第20回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  東京コンベンションホール（東京都中央区）
- Year and Date
  2016-12-16
- Invited
- Data Source
  KAKENHI-PROJECT-16K15471
[Presentation] ACCUMULATION OF ADENOSINE IN THE OUTER STRIPES OF OUTER MEDULLA IN MURINE KIDNEY IDENTIFIED BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION IMAGING MASS SPECTROMETRY.2016
- Author(s)
  K. Fujii, K. Miyashita, A. Kubo, M. Sato, A. Hagiwara, H. Inoue, M. Suematsu, H. Itoh
- Organizer
  26th Scientific Meeting of International Society of Hypertension
- Place of Presentation
  Seoul, South Korea
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] MALDI質量分析イメージング法によるマウス急性腎虚血におけるアデニル酸代謝解析2016
- Author(s)
  久保亜紀子・藤井健太郎・宮下和季・菱木貴子・伊藤裕・末松誠
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K15471
[Presentation] MALDI質量分析イメージング法によるマウス急性腎虚血におけるアデニル酸代謝解析2016
- Author(s)
  久保亜紀子・藤井健太郎・宮下和季・菱木貴子・伊藤　裕・末松　誠
- Organizer
  第89回日本生化学会年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K07203
[Presentation] 多発性子宮筋腫と皮膚平滑筋腫症を認めた Hereditary Leiomyomatosis and Renal Cell Cancerの2例2016
- Author(s)
  梅垣知子、木島俊英、小峰佑奈、伊勢美咲、舩越建、進伸幸、常深祐一郎、林伸和、白石英馨、天谷雅行、久保亮治
- Organizer
  日本皮膚科学会総会2016
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K09782
[Presentation] 低酸素応答によるCori回路の制御機構の解明～肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発～2015
- Author(s)
  壽原朋宏*、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Inactivating HIF-prolyl hydroxylase PHD2 in liver improves survival after lactic acidosis by activating Cori cycle2015
- Author(s)
  Tomohiro Suhara, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima*
- Organizer
  Keystone Symposia “Hypoxia: From Basic Mechanisms to Therapeutics (E3)”.
- Place of Presentation
  Royal Dublin Society (Dublin, Ireland)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] ヒト大腸がん肝転移病巣のin vivo細胞周期依存的エネルギー代謝を質量分析イメージングで可視化する2015
- Author(s)
  久保亜紀子・鮑彦・向井邦晃・菱木貴子・大村光代・南嶋洋司・末松誠
- Organizer
  第８８回日本生化学会大会(BMB2015)
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] 肝臓における低酸素応答はCori回路の活性化を介して血中乳酸レベルを制御している2015
- Author(s)
  壽原朋宏、菱木貴子、笠原正貴、早川典代、小柳津智子、中西豪、久保亜紀子、森崎浩、William G. Kaelin Jr.、末松誠、南嶋洋司*
- Organizer
  第13回がんとハイポキシア研究会
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] 担がん組織切片における過硫化グルタチオン蓄積の質量イメージングによる評価2015
- Author(s)
  久保亜紀子・大村光代・中西　豪・菱木貴子・山本雄広・末松　誠
- Organizer
  第63回質量分析総合討論会
- Place of Presentation
  つくば国際会議場　エポカルつくば（茨城県つくば市）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle2015
- Author(s)
  Tomohiro Suhara*, Takako Hishiki, Masataka Kasahara, Noriyo Hayakawa, Tomoko Oyaizu, Tsuyoshi Nakanishi, Akiko Kubo, Hiroshi Morisaki, William G. Kaelin Jr., Makoto Suematsu, Yoji Andrew Minamishima
- Organizer
  第3回低酸素研究会
- Place of Presentation
  早稲田大学先端生命医科学センター（東京都新宿区）
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26670163
[Presentation] Detection of ammonia on human colon cancer-bearing livers of superimmunideficient NOG mice by MALDI MS imaging2014
- Author(s)
  久保亜紀子・大村　光代・中西　豪・末松　誠
- Organizer
  第62回American Society of Mass Spectrometry 年会
- Place of Presentation
  ボルチモア（米国）
- Year and Date
  2014-06-17
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro2014
- Author(s)
  Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto, Ryo Fukuda, Hideyuki Saya, Makoto Suematsu and Yoji Andrew Minamishima
- Organizer
  Keystone Symposia "Tumor Metabolism (X6)"
- Place of Presentation
  Whistler, BC, Canada
- Data Source
  KAKENHI-PROJECT-23310136
[Presentation] 生体組織切片に含まれるアンモニアの質量イメージング法による評価2014
- Author(s)
  久保亜紀子・大村　光代・中西　豪・末松　誠
- Organizer
  第62回質量分析総合討論会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪府吹田市）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] ヒト大腸がん細胞のin vitro同調培養およびin vivoにおける細胞周期依存的エネルギー代謝2013
- Author(s)
  久保亜紀子・鮑彦・向井邦晃・菱木貴子・大村光代・南嶋洋司・末松誠
- Organizer
  第61回質量分析総合討論会
- Place of Presentation
  つくば国際会議場　エポカルつくば
- Data Source
  KAKENHI-PROJECT-25513008
[Presentation] g-tubulin 2 is required for proper synaptic function2008
- Author(s)
  Akiko Kubo, 他
- Organizer
  日本細胞生物学会第60回年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19890283
[Presentation] -Tubulin2 regulates mitochondrial morphology in neurons2008
- Author(s)
  Akiko Kubo, 他
- Organizer
  48th Annual Meeting The American Society for Cell Biology
- Place of Presentation
  MOSCONE center(サンフランシスコ市)
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-19890283
[Presentation] γ-Tubulin2 regulates mitochondrial morphology in neurons2008
- Author(s)
  Akiko Kubo, 他
- Organizer
  48^<th> Annual Meeting The American Society for Cell Biology
- Place of Presentation
  MOSCONE center (サンフランシスコ市)
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-19890283
[Presentation] γ-tubulin 2 is required for proper synaptic function2008
- Author(s)
  Akiko Kubo, 他
- Organizer
  日本細胞生物学会第60回年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19890283

1. HISHIKI Takako (10338022)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
2. MINAMISHIMA Yoji Andrew (20593966)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
3. MIYASHITA Kazutoshi (50378759)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. 久保亮治 (70335256)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
5. 福本毅 (80778770)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. Umegaki Noriko (80397629)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
7. YACHIE Ayako (10453549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KASAHARA Masataka (30328265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MINAMISHIMA Shizuka (20622088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAKOTO Suematsu (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Takehiro (50383774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. Itoh Hiroshi (40252457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. Yuki Sugiura (30590202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UDONO Heiichiro (50260659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. KANEKO Osamu (50325370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Kajimura Mayumi (10327497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. Kawakami Yutaka (50161287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 城口克之 (00454059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 永宗喜三郎 (90314418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 潮見隆之 (80348797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 木内謙一郎 (50528578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 藤原進 (40645389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 小野竜輔 (50595486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 吉岡愛育 (60988228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 加藤果野子 (40928587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 加藤侑希 (60733649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. FUJII Kentaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
28. SATO Masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
29. MIYAZAKI Shinya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. CHAIYAWONG Nattawat

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. SATTABONGKOT Jetsumon

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. ROOBSOONG Wanlapa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. JENWITHISUK Rachaneeporn

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. KANGWANRANGSAN Niwat

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. PATRAPUVICH Rapatbhorn

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. RATHOD Pradipsinh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. ISOJIMA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. HAYASHI Kaori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. OHTA Shigeki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 佐瀬一洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 大津洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 佐谷秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 佐々木貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 塩濱愛子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 加部泰明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 岩田卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubo Akiko 久保 亜紀子

AKIKO Kubo 久保 亜紀子

KUBO Akiko 久保 亜希子

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角層天然保湿因子の質量分析イメージング解析による魚鱗癬の病態解明と治療評価Principal Investigator

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Elucidation of the mechanism of diabetic nephropathy pathogenesis and development of preventive methods focusing on the metabolism of branched-chain amino acids during hyperglycaemia.Principal Investigator

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In vivo metabolomic analysis and metabolic alteration-targeted treatment on diabetic nephropathy model .Principal Investigator

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Kubo Akiko 久保亜紀子

AKIKO Kubo 久保亜紀子

KUBO Akiko 久保亜希子