Yamaguchi Shintaro 山口慎太郎

… Alternative Names

YAMAGUCHI Shintaro 山口慎太郎

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Researcher Number	50464855
Other IDs	https://orcid.org/0000-0002-4917-033X
Affiliation (Current)	2024: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 慶應義塾大学, 医学部(信濃町), 講師 2020: 慶應義塾大学, 医学部(信濃町), 助教 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 特任助教 2014 – 2016: 慶應義塾大学, 医学部, 特任助教 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Kidney internal medicine Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator インスリン抵抗性 / NMN / 肥満 / 2型糖尿病 / 脂肪組織 / 血管内皮細胞NAD(+)合成系 / NAD(+)中間代謝産物 / 血管内皮細胞 / NAD(+)合成系 / NAMPT … More / NAD中間代謝産物NMN / 腸管NAMPT-NAD合成系 / インクレチン / NAMPT-NAD+合成系 / インクレチン分泌 / インスリン初期分泌不全 / 腸管NAD+合成系 / 腸管NAMPT / 食後高血糖 / インクレンチン / 腸管 / NAD合成系 / 尿細管前駆細胞 / tubular organoids / 尿細管細胞 / ヒトES・iPS細胞 / ヒト多能性幹細胞 / 尿細管 / 腎臓再生 … More Except Principal Investigator ヒトES細胞 / 腎臓構成細胞 / 尿細管上皮細胞 / 糸球体内皮細胞 / ヒトiPS細胞 / 尿細管細胞 / 内皮細胞 / 慢性腎臓病 Less

脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防Principal Investigator
- Principal Investigator
  
  山口慎太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Keio University
Therapeutic potential of intestinal epithelial NAMPT-mediated NAD+ biosynthesis in insulin resistancePrincipal Investigator
- Principal Investigator
  
  Yamaguchi Shintaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Keio University
The use of human pluripotent stem-cell-derived renal/vascular precursors and organ decellularization for the generation of a kidney organoidPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Shintaro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Generation of kidney tubular cells from human pluripotent stem cells
- Principal Investigator
  
  Homma Koichiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University
Clarification of new pathological mechanisms for chronic kidney disease using technology that induces endothelial cells from human ES/iPS cells
- Principal Investigator
  
  HOMMA Koichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2016 2013

All Journal Article Presentation

[Journal Article] Compared effectiveness of sodium zirconium cyclosilicate and calcium polystyrene sulfonate on hyperkalemia in patients with chronic kidney disease.2023
- Author(s)
  Nakayama T, Yamaguchi S (corresponding author), Hayashi K, Uchiyama K, Tajima T, Azegami T, Morimoto K, Yoshida T, Yoshino J, Monkawa T, Kanda T, Itoh H.
- Journal Title
  
  Frontiers in Medicine (Lausanne)
  
  Volume: 10 Pages: 1137981-1137981
- DOI
  10.3389/fmed.2023.1137981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07377
[Journal Article] Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism.2023
- Author(s)
  Nagahisa T, Kosugi S, Yamaguchi S (last and corresponding author).
- Journal Title
  
  Nutrients
  
  Volume: 15(6) Issue: 6 Pages: 1494-1494
- DOI
  10.3390/nu15061494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07377
[Journal Article] Intestinal epithelial NAD(+) biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice2022
- Author(s)
  Nagahisa Taichi, Yamaguchi Shintaro, Kosugi Shotaro, Homma Koichiro, Miyashita Kazutoshi, Irie Junichiro, Yoshino Jun, Itoh Hiroshi
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 4 Pages: 1-12
- DOI
  10.1210/endocr/bqac023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K08584, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20H00535
[Journal Article] Nicotinamide mononucleotide prevents retinal dysfunction in a mouse model of retinal ischemia/reperfusion injury.2022
- Author(s)
  Lee D, Tomita Y, Miwa Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 23 Issue: 19 Pages: 11228-11228
- DOI
  10.3390/ijms231911228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20K18393
[Journal Article] Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion.2022
- Author(s)
  Yamamoto R, Suzuki S, Homma K, Yamaguchi S, Sujino T, Sasaki J.
- Journal Title
  
  World J Gastrointest Surg.
  
  Volume: 14(12) Issue: 12 Pages: 1329-1339
- DOI
  10.4240/wjgs.v14.i12.1329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-22K16631, KAKENHI-PROJECT-20K17873
[Journal Article] Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion.2022
- Author(s)
  Lee D, Tomita Y, Miwa Y, Jeong H, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 14711-14711
- DOI
  10.3390/ijms232314711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20K18393
[Journal Article] Circadian transcription factor NPAS2 and the NAD(+)‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward2022
- Author(s)
  Becker‐Krail Darius D., Parekh Puja K., Ketchesin Kyle D., Yamaguchi Shintaro, Yoshino Jun, Hildebrand Mariah A., Dunham Brandan, Ganapathiraju Madhavi K., Logan Ryan W., McClung Colleen A.
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 55 Issue: 3 Pages: 675-693
- DOI
  10.1111/ejn.15596
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382
[Journal Article] Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection. Journal of Clinical Medicine2022
- Author(s)
  Nakayama T, Nishioka K, Uchiyama K, Morimoto K, Kusahana E, Washida N, Yamaguchi S, Azegami T, Yoshida T, Itoh H.
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 13 Issue: 14 Pages: 4042-4042
- DOI
  10.3390/jcm11144042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07377
[Journal Article] Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility2021
- Author(s)
  Franczyk Michael P、Qi Nathan、Stromsdorfer Kelly L、Li Chengcheng、Yamaguchi Shintaro、Itoh Hiroshi、Yoshino Mihoko、Sasaki Yo、Brookheart Rita T、Finck Brian N、DeBosch Brian J、Klein Samuel、Yoshino Jun
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 3 Pages: 1-12
- DOI
  10.1210/endocr/bqab006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-20K23382
[Journal Article] 超高齢社会日本におけるNAD+生物学トランスレーショナル研究の意義と可能性2020
- Author(s)
  山口慎太郎、伊藤裕、吉野純
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 57 Issue: 3 Pages: 213-223
- DOI
  10.3143/geriatrics.57.213
- NAID
  130007896410
- Data Source
  KAKENHI-PROJECT-18K15399
[Journal Article] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men2020
- Author(s)
  Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H
- Journal Title
  
  Endocr J
  
  Volume: 67 Issue: 2 Pages: 153-160
- DOI
  10.1507/endocrj.EJ19-0313
- NAID
  130007802884
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08526, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-17H04353, KAKENHI-PROJECT-20H00535
[Journal Article] Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors.2019
- Author(s)
  Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, Kimura H, Chikazawa-Nohtomi N, Sato S, Ishiguro K, Yamaguchi S, Suzuki S, Morizane R, Ko SBH, Itoh H, Ko MSH
- Journal Title
  
  Scientific reports
  
  Volume: 9 Issue: 1 Pages: 913-913
- DOI
  10.1038/s41598-018-37485-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K19304, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-17H03634, KAKENHI-PROJECT-17K15129
[Journal Article] Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice2019
- Author(s)
  Yamaguchi Shintaro、Franczyk Michael P.、Chondronikola Maria、Qi Nathan、Gunawardana Subhadra C.、Stromsdorfer Kelly L.、Porter Lane C.、Wozniak David F.、Sasaki Yo、Rensing Nicholas、Wong Michael、Piston David W.、Klein Samuel、Yoshino Jun
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 47 Pages: 23822-23828
- DOI
  10.1073/pnas.1909917116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15399
[Journal Article] NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism2018
- Author(s)
  Lane C. Porter, Michael P. Franczyk, Terri Pietka, Shintaro Yamaguchi, Jonathan B. Lin, Yo Sasaki, Eric Verdin, Rajendra S. Apte, Jun Yoshino
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 315 Issue: 4 Pages: E520-E530
- DOI
  10.1152/ajpendo.00057.2018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15399
[Journal Article] NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward2018
- Author(s)
  Logan Ryan W.、Parekh Puja K.、Kaplan Gabrielle N.、Becker-Krail Darius D.、Williams Wilbur P.、Yamaguchi Shintaro、Yoshino Jun、Shelton Micah A.、Zhu Xiyu、Zhang Hui、Waplinger Spencer、Fitzgerald Ethan、Oliver-Smith Jeffrey、Sundarvelu Poornima、Enwright John F.、Huang Yanhua H.、McClung Colleen A.
- Journal Title
  
  Molecular Psychiatry
  
  Volume: - Issue: 11 Pages: 1668-1684
- DOI
  10.1038/s41380-018-0061-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15399
[Journal Article] Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People.2018
- Author(s)
  Shintaro Yamaguchi, Anna C Moseley, Paloma Almeda-Valdes, Kelly L Stromsdorfer, Michael P Franczyk, Adewole L Okunade, Bruce W Patterson, Samuel Klein, Jun Yoshino
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 103 Issue: 3 Pages: 1068-1076
- DOI
  10.1210/jc.2017-02230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15399
[Journal Article] Generation of kidney tubular organoids from human pluripotent stem cells2016
- Author(s)
  Yamaguchi S, Morizane R, Homma K, Monkawa T, Suzuki S, Fujii S, Koda M, Hiratsuka K, Yamashita M, Yoshida T, Wakino S, Hayashi K, Sasaki J, Hori S, Itoh H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 38353-38353
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461231
[Presentation] 肥満に伴う腸管NAMPT-NAD+合成系の障害によりインクレチン合成・全身の糖代謝は悪化する2022
- Author(s)
  永久太一, 山口慎太郎, 小杉将太郎, 宮下和季, 入江潤一郎, 吉野純, 伊藤裕
- Organizer
  第42回日本肥満学会・第39回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] The role of intestinal NAMPT-mediated NAD+ biosynthesis in whole-body energy and glucose metabolism.2022
- Author(s)
  Yamaguchi S, Nagahisa T, Kosugi S, Nishioka K, Watanabe Y, Homma K, Miyashita K, Irie J, Yoshino J, Itoh H.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension (Japan・Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] NAD+生物学が与える抗肥満・抗老化法の可能性.2022
- Author(s)
  吉野純、山口慎太郎、伊藤裕.
- Organizer
  第43回日本肥満学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] エネルギー代謝制御における脂肪細胞NAD+合成系の役割2022
- Author(s)
  山口慎太郎, 吉野純, 伊藤裕
- Organizer
  第42回日本肥満学会・第39回日本肥満症治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] NAMPT-mediated NAD+ biosynthesis in intestinal epithelium regulates GLP-1 production and postprandial glucose levels in mice.2022
- Author(s)
  Yamaguchi S, Nagahisa T, Kosugi S, Nishioka K, Watanabe Y, Yoshino J, Itoh H.
- Organizer
  The 43rd Annual Meeting of the Japan Society for the Study of Obesity International Satellite Symposium: The 5Gｓon Obesity and Diabetes Research
- Invited
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] 腸管NAMPT-NAD+合成系を標的としたGLP-1分泌制御による食後高血糖への介入.2022
- Author(s)
  山口慎太郎、永久太一、小杉将太郎、西岡謙、渡辺康博、宮下和季、入江潤一郎、吉野純、伊藤裕.
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] エネルギー代謝制御における脂肪細胞NAD+合成系の役割.2022
- Author(s)
  山口慎太郎、吉野純、伊藤裕.
- Organizer
  第42回日本肥満学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] Vascular endothelial NAMPT-mediated NAD+ biosynthesis regulates whole-body blood pressure and insulin resistance.2022
- Author(s)
  Kosugi S, Yamaguchi S, Homma K, Nagahisa T, Nishioka K, Watanabe Y, Kinouchi K, Hayashi K, Miyashita K, Kanda T, Irie J, Yoshino J, Itoh H.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension (Japan・Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377
[Presentation] 腸管NAMPT-NAD+合成系はインクレチン合成調節により全身の糖代謝を制御する2020
- Author(s)
  山口慎太郎、永久太一、小杉将太郎、宇都飛鳥、宮下和季、吉野純、入江潤一郎、伊藤裕
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15399
[Presentation] 腸管N A M P T- N A D +合成系はインクレチン合成調節により全身の糖代謝を制御する2020
- Author(s)
  山口慎太郎、永久太一、小杉将太郎、宇都飛鳥、宮下和季、吉野純、入江潤一郎、伊藤裕
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K15399
[Presentation] NAD+合成系賦活化に基づく2型糖尿病およびその合併症予防・治療の試み2020
- Author(s)
  山口慎太郎、吉野純、永久太一、小杉将太郎、三石正憲、入江潤一郎、脇野修、伊藤裕
- Organizer
  第35回日本糖尿病合併症学会年次学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15399
[Presentation] The pathophysiological roles of intestinal NAMPT-mediated NAD+ biosynthesis in whole body glucose metabolism.2019
- Author(s)
  Shintaro Yamaguchi, Taichi Nagahisa, Junichiro Irie and Hiroshi Itoh.
- Organizer
  The 10th APRU Population Aging Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15399
[Presentation] ヒトES細胞を用いた尿細管上皮細胞の分化誘導の試み2013
- Author(s)
  山口慎太郎、本間康一郎、門川俊明、森実隆司、鈴木さゆり、藤井静花、脇野修、林晃一、伊藤裕
- Organizer
  第56回日本腎臓学会総会
- Place of Presentation
  東京
- Year and Date
  2013-05-10
- Data Source
  KAKENHI-PROJECT-23790953

1. HOMMA Koichiro (10383762)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. SUZUKI Sayuri (90445445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 木内謙一郎 (50528578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. ODA Mayumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 伊藤裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamaguchi Shintaro 山口 慎太郎

YAMAGUCHI Shintaro 山口 慎太郎

Research Projects

Research Products

Co-Researchers

脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic potential of intestinal epithelial NAMPT-mediated NAD+ biosynthesis in insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The use of human pluripotent stem-cell-derived renal/vascular precursors and organ decellularization for the generation of a kidney organoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of kidney tubular cells from human pluripotent stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of new pathological mechanisms for chronic kidney disease using technology that induces endothelial cells from human ES/iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Compared effectiveness of sodium zirconium cyclosilicate and calcium polystyrene sulfonate on hyperkalemia in patients with chronic kidney disease.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal epithelial NAD(+) biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nicotinamide mononucleotide prevents retinal dysfunction in a mouse model of retinal ischemia/reperfusion injury.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circadian transcription factor NPAS2 and the NAD(+)‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection. Journal of Clinical Medicine2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility2021

Author(s)

Journal Title

DOI

Data Source

Yamaguchi Shintaro 山口慎太郎

YAMAGUCHI Shintaro 山口慎太郎