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ROKUDAI Susumu  勝本 拓夫

ORCIDConnect your ORCID iD *help
Researcher Number 50469970
Other IDs
Affiliation (based on the past Project Information) *help 2010 – 2012: 独立行政法人国立がん研究センター, 研究所, 研究員
2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 分子腫瘍学部, 研究員
2008 – 2009: 国立がんセンター(研究所及び東病院臨床開発センター), 分子腫瘍学部, 研究員
2007: 国立がんセンター研究所, 分子腫瘍学部, 研究員
Review Section/Research Field
Principal Investigator
Hematology
Except Principal Investigator
Hematology
Keywords
Principal Investigator
遺伝子発現制御 / 融合遺伝子 / 急性骨髄性白血病 / 発生・分化 / 幹細胞 / 癌 / 発現制御 / ヒストンアセチル化酵素 / 転写制御因子 / 自己複製 / 造血幹細胞 … More
Except Principal Investigator
… More 白血病 / 幹細胞 / NPMc / NPM / YB-1 / nucleophosmin / acute myeloid leukemia / 血液腫瘍学 / PML / 細胞分化 / GATA / PU.1 / MOZ / 造血幹細胞 / 転写制御 Less
  • Research Projects

    (4 results)
  • Research Products

    (49 results)
  • Co-Researchers

    (4 People)
  •  Analysis of acute myeloid leukemia development mechanisms induced by MOZ/MLL fusion genesPrincipal Investigator

    • Principal Investigator
      KATSUMOTO Takuo
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Japan
  •  Development of the novel AML treatments by targeting leukemia stem cells

    • Principal Investigator
      KITABAYASHI Issay
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Japan
  •  Roles of leukemia related factor MOZ and MORF in self-renewal of hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      KATSUMOTO Takuo
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  Study for regulatory mechanism of normal and leukemic stem cells through transcription factors

    • Principal Investigator
      KITABAYASHI Issay
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] MOZ increases p53 acetylation and premature senescence through its complex formation with PML.2013

    • Author(s)
      Rokudai S
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 10 Pages: 3895-3900

    • DOI

      10.1073/pnas.1300490110

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-22390197, KAKENHI-PLANNED-22130006
  • [Journal Article] MOZ increases p53 acetylation and premature senescence through its complex formation with PML.2013

    • Author(s)
      Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Pages: 3895-3900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390197
  • [Journal Article] 造血器腫瘍学―転写制御2012

    • Author(s)
      勝本 拓夫
    • Journal Title

      日本臨床

      Volume: 70 Pages: 75-78

    • Data Source
      KAKENHI-PROJECT-23791094
  • [Journal Article] 造血器腫瘍 転写制御2012

    • Author(s)
      勝本拓夫、北林一生
    • Journal Title

      日本臨床

      Volume: 70 Pages: 75-78

    • Data Source
      KAKENHI-PROJECT-23791094
  • [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011

    • Author(s)
      Mishima Y
    • Journal Title

      Blood

      Volume: 118 Issue: 9 Pages: 2443-2453

    • DOI

      10.1182/blood-2011-01-331892

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22116513, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-23791094
  • [Journal Article] 転写共役因子を介した造血幹細胞と白血病幹細胞の制御機構2011

    • Author(s)
      勝本拓夫、北林一生
    • Journal Title

      Mebio

      Volume: 28 Pages: 9-17

    • Data Source
      KAKENHI-PROJECT-23791094
  • [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.2011

    • Author(s)
      Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Takaho A. Endo, Tetsuro Toyoda, Jun Shinga, Takuo Katsumoto, Tetsuhiro Chiba, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama
    • Journal Title

      Blood

      Volume: 118 Pages: 2443-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.2011

    • Author(s)
      Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
    • Journal Title

      Blood

      Volume: 118 Pages: 2443-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390197
  • [Journal Article] Characterization of Spheres Derived from Canine Mammary Gland Adenocarcinoma Cell Lines.2010

    • Author(s)
      Masaki Michishita, Rui Akiyoshi, Hisashi Yoshimura, Takuo Katsumoto, Hitoshi Ichikawa, Kozo Ohkusu-Tsukada, Takayuki Nakagawa, Nobuo Sasaki, Kimimasa Takahashi
    • Journal Title

      Research in Veterinary Science (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Journal Article] PU.1-mediated upregulation of M-CSFR is critical for MOZ-leukemia stem cell potential2010

    • Author(s)
      Yukiko Aikawa, Takuo Katsumoto, Pu Zhang, Haruko Shima, Mika Shino, Kiminori Terui, Etsuro Ito, Hiroaki Ohno, E.Richard Stanley, Harinder Singh, Daniel G Tenen, Issay Kitabayashi
    • Journal Title

      Nat.Med. 16

      Pages: 580-585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Journal Article] 1-mediated upregulation of M-CSFR is critical for leukemia stem cell potential induced by MOZ-TIF2.2010

    • Author(s)
      Aikawa Y, Katsumoto K, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I. PU.
    • Journal Title

      Nat Med 16

      Pages: 580-585

    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] PU.1-mediated upregulation of M-CSFR is critical for leukemia stem cell potential induced by MOZ-TIF2.2010

    • Author(s)
      Aikawa Y, Katsumoto K, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I
    • Journal Title

      Nat Med

      Volume: 16 Pages: 580-585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390197
  • [Journal Article] Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons2009

    • Author(s)
      Kenta Hibiya, Takuo Katsumoto, Takashi Kondo, Issay Kitabayashi, Akira Kudo
    • Journal Title

      Dev Biol. 329

      Pages: 176-190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Journal Article] Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons.2009

    • Author(s)
      Kenta Hibiya, Takuo Katsumoto
    • Journal Title

      Developmental Biology 329

      Pages: 176-190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Journal Article] MOZ interacts with p53 to induce p21 expression and cell-cycle arrest2009

    • Author(s)
      Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I.
    • Journal Title

      J Biol Chem. 284

      Pages: 237-244

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] MOZ interacts with p53 to induce p21 expression and cell-cycle arrest.2009

    • Author(s)
      Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I.
    • Journal Title

      J Biol Chem. 284

      Pages: 237-244

    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bonemarrow hematopoiesis and thymocyte differentiation2008

    • Author(s)
      Tachibana M, Tezuka C, Muroi S, Nishimoto S, Katsumoto T, Nakajima A, Kitabayashi I
    • Journal Title

      Biochem Biophys Res Commun 368

      Pages: 536-542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008

    • Author(s)
      Katsumoto T, Yoshida N, Kitabayashi I
    • Journal Title

      Cancer Sci. 99

      Pages: 1523-7

    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Phosphorylation of Runx1 at Ser249,Ser266,and Ser276 is dispensable for bonemarrow hematopoiesis and thymocyte differentiation.2008

    • Author(s)
      Tachibana M, Tezuka C, Muroi S, Nishimoto S, Katsumoto T, Nakajima A, Kitabayashi I, Taniuchi I.
    • Journal Title

      Biochem Biophys Res Commun. 368

      Pages: 536-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis.2008

    • Author(s)
      T. Katsumoto, H. Yoshida, I. Kitabayashi.
    • Journal Title

      Cancer Sci. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Roles of the histone acetyltransferase MOZ in normal and malignant hematopoiesis2008

    • Author(s)
      Katsumoto T, Yoshida N, Kitabayashi I
    • Journal Title

      Cancer Sci 99

      Pages: 1523-1527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription.2007

    • Author(s)
      Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
    • Journal Title

      Oncogene. 26

      Pages: 7231-7239

    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] PML-RARA inhibits PML IV enhancement of PU.1-induced C/EBPe induced-expression in myeloid differentiation.2007

    • Author(s)
      Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
    • Journal Title

      Mol.Cell.Biol. 27

      Pages: 5819-5834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] PML-RARA inhibits PML IV enhancement of PU. 1-induced C/EBPe induced-expression in myeloid differentiation.2007

    • Author(s)
      Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 5819-5834

    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1-and p53-mediated transcription.2007

    • Author(s)
      Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I.
    • Journal Title

      Oncogene 26

      Pages: 7231-7239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Journal Article] PU.1-mediated upregulation of M-CSFR is critical for MOZ-leukemia stem cell potential.

    • Author(s)
      Yukiko Aikawa, Takuo Katsumoto
    • Journal Title

      Nature Medicine (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] ヒストンアセチル化酵素MOZの急性骨髄性白血病における役割2012

    • Author(s)
      勝本拓夫
    • Organizer
      平成23年度個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      琵琶湖ホテル
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Roles of MOZ in leukemia development and HoxA9/Meis1 expression2012

    • Author(s)
      勝本拓夫、山形和恒、北林一生
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌, 他
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] MOZ is critical for MOZ/MLL-fusion-induced HoxA9/Meis1 expression and leukemia development2012

    • Author(s)
      勝本拓夫、北林一生
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Critical pathways for maintenance of stem cells in acute myeloid leukemia2012

    • Author(s)
      嶋晴子、相川祐規子、篠美花、山形和恒、勝本拓夫、古関明彦、渡邊利雄、北林一生
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路夢舞台
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Histone acetyltransferase MORF and MOZ are essential for hematopoiesis and self renewal of hematopoietic stem cells2012

    • Author(s)
      Takuo Katsumoto
    • Organizer
      10th ISSCR annual meeting
    • Place of Presentation
      Pacifico Yokohama
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Histone acetyltransferase MORF and MOZ are essential for hematopoiesis and self renewal of hematopoietic stem cells2012

    • Author(s)
      Takuo Katsumoto, Issay Kitabayashi
    • Organizer
      10^<th> ISSCR annual meeting
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] ヒストンアセチル化酵素MOZの急性骨髄性白血病における役割2012

    • Author(s)
      勝本 拓夫
    • Organizer
      「個体レベルでのがん研究支援活動」ワークショップ
    • Place of Presentation
      琵琶湖ホテル
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] MOZ is critical for MOZ/MLL-fusion induced HoxA9/Meis1 expression and leukemia development2011

    • Author(s)
      Takuo Katsumoto, Issay Kiyabayashi
    • Organizer
      53^<rd> ASH annual meeting and exposition
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Histone acetyltransferase MOZ and MORF are essential for hematopoiesis and self renewal of hematopoietic stem cells2011

    • Author(s)
      勝本拓夫、北林一生
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      泉ガーデンギャラリー
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] MOZ is critical for MOZ/MLL-fusion-induced HoxA9/Meis1 expression and leukemia development2011

    • Author(s)
      Takuo katsumoto
    • Organizer
      53rd ASH annual meeting and exposition
    • Place of Presentation
      San Diego Convention Center (USA)
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] The critical role of YB-1 in NPMc-induced acute myeloid leukemia2011

    • Author(s)
      小川原陽子、勝本拓夫、内海健、河野公俊、北林一生
    • Organizer
      第73回日本血液学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23791094
  • [Presentation] Roles of histone acetyltransferase MORF and MOZ in hematopoiesis2010

    • Author(s)
      勝本拓夫、北林一生
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] The role of YB-1, a binding partner of nucleophosmin, in hematopoiesis and nucleophosmin mutant (NPMc)-associated acute myeloid leukemia.2010

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Takeshi Uchiumi, Kimitoshi Kohno, Issay Kitabayashi
    • Organizer
      2010 AACR/JCR Joint Conference Hilton waikoloa Village in Hawaii
    • Place of Presentation
      USA
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Presentation] Roles of Ring1A/B and ROS in stem cell potential of MOZ and other myeloid leukemias2010

    • Author(s)
      嶋晴子、山中久美子、相川祐規子、勝本拓夫、篠美花、古関明彦、北林一生
    • Organizer
      第72回日本血液学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Roles of histone acetyltransferase MORF and MOZ in hematopoiesis2009

    • Author(s)
      勝本拓夫、北林一生
    • Organizer
      第71回日本血液学会学術総会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Roles of histone acetyltransferase MORF and MOZ in hematopoiesis.2009

    • Author(s)
      T.Katsumoto
    • Organizer
      51^<st> ASH annual meeting and exposition
    • Place of Presentation
      Ernest N. Morial Convention Center (USA)
    • Year and Date
      2009-12-06
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Roles of histone actyltransferases MOZ/MORF in hematopoiesis and leukemia2009

    • Author(s)
      Yukiko Aikawa, Takuo Katsumoto, Issay Kitabayashi
    • Organizer
      Runx Meeting 2009
    • Place of Presentation
      Oxford University
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Presentation] PU. 1-mediated upregulation of M-CSFR is critical for MOZ-leukemia stem cell potential2009

    • Author(s)
      Yukiko Aikawa1, Takuo Katsumoto1, Daniel G Tenen, Issay Kitabayashi1
    • Organizer
      51th annual meeting of American Society of Hemaology Ernest N.
    • Place of Presentation
      Merial Convention Center New Orleans
    • Data Source
      KAKENHI-PROJECT-19390268
  • [Presentation] MOZは、MOZ/MLL融合遺伝子による白血病細胞化に必須である2009

    • Author(s)
      勝本拓夫、相川祐規子、北林一生
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Histone acetyltransferase MOZ and MORF are essential for self-renewal of hematopoietic stem cells2009

    • Author(s)
      勝本拓夫
    • Organizer
      第7回幹細胞シンポジウム
    • Place of Presentation
      泉ガーデンギャラリー(東京都)
    • Year and Date
      2009-05-16
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Roles of histone acetyltransferase MORF and MOZ in hematopoiesis2009

    • Author(s)
      Takuo Katsumoto, Issay Kitabayashi
    • Organizer
      51^<st> ASH annual meeting and exposition
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] Histone acetyltransferase MOZ and MORF are essential for self-renewal of hematopoietic stem cells2009

    • Author(s)
      勝本拓夫、北林一生
    • Organizer
      第7回幹細胞シンポジウム
    • Place of Presentation
      泉ガーデンタワー
    • Data Source
      KAKENHI-PROJECT-21790927
  • [Presentation] PU.1-mediated upregulation of CSF1R/cFMSIM-CSFR is critical for MOZ- and MLL-leukemia stem cell potential2008

    • Author(s)
      Yukiko Aikawa, Takuo Katsumoto, Naomi Yoshida, Kazutsune Yamagata, Akihiko Yokoyama, Issay Kitabayashi
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19390268
  • 1.  YOSHIDA Hitoshi (10506710)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 2.  KITABAYASHI Issay (20261175)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 3.  YAMAGATA Kazutsune (70311412)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  WATANABE Toshio (60201208)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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