Shimizu Shino 清水志乃

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SHIMIZU Shino 清水志乃

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Researcher Number	50505592
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 医学部, 客員講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 滋賀医科大学, 医学部, 客員講師 2010 – 2022: 滋賀医科大学, 医学部, 医員
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 好酸球性副鼻腔炎 / 好酸球性鼻副鼻腔炎 / 鼻茸線維芽細胞 / アルツハイマー病 / VEGF / 好酸球 / トロンビン / COVID-19 / ブレインフォグ / 嗅上皮 … More / 嗅覚障害 / カニクイザル / SARS-CoV-2 / 慢性副鼻腔炎 / 鼻腔洗浄液 / 細胞外小胞 / エクソソーム / 凝固系因子 / 耳鼻咽喉科学 / PARs / fibronectin / GM-CSF / 活性化第１０因子 / 線維芽細胞 / EGF受容体インヒビター / RANTES / eotaxin / TGF-beta / フィブロネクチン / 血液凝固因子 / 嗅粘膜 / タウ蛋白 / アミロイドβ / ヒト鼻腔 / 早期診断 / 鼻茸形成 / 粘液産生亢進 / トロンビン-アンチトリンビン複合体 / 好酸球性副腔炎 / 粘液産生 / 組織因子経路インヒビター / 杯細胞化生 / 凝固因子 / 組織因子 / ヘパリン / 鼻茸 … More Except Principal Investigator スギ花粉症 / 好酸球性副鼻腔炎 / amphiregulin / TGF-alpha / 慢性副鼻腔炎 / ＭＵＣ５ＡＣ / 鼻茸形成 / ＥＧＦ受容体 / 組織リモデリング / 上皮細胞 / 好酸球 / 抗原特異的免疫グロブリン / 末梢血単核球サブセット / ダニアレルギー性鼻炎 / アポトーシス / 抗原親和性 / IL-35 / IL-10 / メモリーT細胞 / 制御性T細胞 / 抗原特異的IgE抗体 / スギ・ヒノキ花粉症 / 舌下免疫療法 / ＨＭＧＢ１ / Ｓ１００蛋白 / 好酸球性鼻副鼻腔炎 / ＩＬ－１８ / プロテアーゼ / アレルギー性鼻炎 / HMGB-1 / アラーミン / NADPH oxidase / TSLP / IL-33 / IL-25 / Calprotectin / HMGB1 / 酸化ストレス / 神経病理 / 鼻粘膜 / 診断 / 認知症 / アルツハイマー病 / 脳神経疾患 / IL-8 / ＴＮＦ－alpha / 杯細胞化生 / ＬＰＳ / ＩＬ－８ / ＥＧF受容体阻害薬 / サイトカイン / 線維芽細胞 / 鼻粘膜上皮細胞 / ラット鼻粘膜 / ＥＧＦ受容体阻害薬 / ADAM / EGFR / ムチン / 気道上皮細胞 / MUC5AC / 鼻茸 / 粘液産生 / 鼻副鼻腔炎 Less

カニクイザルのSARS-Cov-2感染モデルを利用した嗅覚障害発症機序の解明Principal Investigator
- Principal Investigator
  
  清水志乃
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
New understanding of the immune mechanism of sublingual immunotherapy
- Principal Investigator
  
  清水猛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
Development of new diagnostic methods by extracellular vesicles in nasal lavage fluidsPrincipal Investigator
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
Role of innate immunity in the pathogenesis of eosinophilic chronic rhinosinusitis: Alermin and IL-18
- Principal Investigator
  
  Takao Ogawa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophilsPrincipal Investigator
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Tissue remodering of eosinophilic chronic rhinosinusitis
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's DiseasePrincipal Investigator
- Principal Investigator
  
  Shimizu Shino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling
- Principal Investigator
  
  SHIMIZU TAKESHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science
Role of coagulation factors in the eosinophilic inflammation of upper airwaysPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Shino
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shiga University of Medical Science

[Book] Recent Advances in Rhinosinusitis and Nasal Polyposis2015
- Author(s)
  Shimizu T, Shimzu S, Ogawa T, Takezawa K, Kouzaki H
- Publisher
  Kugler Publications, Amsterdam
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates2024
- Author(s)
  Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, Ichiro Tojima, Hideaki Kouzaki, and Takeshi Shimizu
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 387 Pages: 578288-578288
- DOI
  10.1016/j.jneuroim.2024.578288
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09704, KAKENHI-PROJECT-23K07921
[Journal Article] Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites2023
- Author(s)
  Murao Takuya、Kouzaki Hideaki、Arai Hiroyuki、Matsumoto Koji、Nakamura Keigo、Kawakita Kento、Tojima Ichiro、Shimizu Shino、Yuta Atsushi、Shimizu Takeshi
- Journal Title
  
  International Forum of Allergy & Rhinology
  
  Volume: 14 Issue: 1 Pages: 57-67
- DOI
  10.1002/alr.23221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CLINICAL EFFICASY OF HOUSE DUST MITE SUBLINGUAL IMMUNOTHERAPY WITH MITICURE® TABLETS IN 115 PAITENTS FOR 3 YEARS2023
- Author(s)
 湯田厚司、小川由起子、神前英明、清水猛史
- Journal Title
 
 Japanese Journal of Allergology
 
 Volume: 72 Issue: 3 Pages: 273-280
- DOI
 10.15036/arerugi.72.273
- ISSN
 0021-4884, 1347-7935
- Language
 Japanese
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] Sublingual immunotherapy decreases the avidity of antigen‐specific IgE in patients with Japanese cedar pollinosis2023
- Author(s)
  Nakamura Keigo、Kouzaki Hideaki、Murao Takuya、Kawakita Kento、Arai Hiroyuki、Matsumoto Koji、Kubo Yoshihito、Tojima Ichiro、Shimizu Shino、Ogawa Yukiko、Yuta Atsushi、Sakai Rika、Ohno Hitoshi、Kido Hiroshi、Shimizu Takeshi
- Journal Title
  
  Allergy
  
  Volume: 78 Issue: 12 Pages: 3268-3271
- DOI
  10.1111/all.15900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CLINICAL EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH CEDAR POLLEN IN A YEAR OF MASSIVE CEDAR POLLEN DISPERSAL AND ITS EFFECT ON JAPANESE CYPRESS POLLINOSIS2023
- Author(s)
  湯田厚司、小川由起子、神前英明、清水猛史
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 72 Issue: 10 Pages: 1230-1239
- DOI
  10.15036/arerugi.72.1230
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] CROSSTALK BETWEEN INNATE AND ACQUIRED IMMUNITY IN ALLERGEN IMMUNOTHERAPY2022
- Author(s)
  神前英明、中村圭吾、湯田厚司、清水猛史
- Journal Title
  
  Japanese Journal of Allergology
  
  Volume: 71 Issue: 10 Pages: 1207-1210
- DOI
  10.15036/arerugi.71.1207
- ISSN
  0021-4884, 1347-7935
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24492
[Journal Article] Sublingual immunotherapy with Japanese cedar pollen extract induces apoptosis of memory CD4 + T cells2022
- Author(s)
 Arai Hiroyuki、Kouzaki Hideaki、Murao Takuya、Nakamura Keigo、Kawakita Kento、Matsumoto Koji、Kikuoka Hirotaka、Yuta Atsushi、Shimizu Takeshi
- Journal Title
 
 Clinical & Experimental Allergy
 
 Volume: 52 Issue: 8 Pages: 974-978
- DOI
 10.1111/cea.14183
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] ENHANCED CLINICAL EFFECTS OF CEDARCURE® TABLETS OF SUBLINGUAL IMMUNOTHERAPY OVER THE YEARS OF TREATMENT AND THE IMPACT OF OUTCOME BY COMBINED USE OF MITE SUBLINGUAL IMMUNOTHERAPY (DUAL SLIT) FOR JAPANESE CEDAR POLLINOSIS2022
- Author(s)
 湯田厚司、小川由起子、村尾拓哉、神前英明、清水猛史
- Journal Title
 
 Japanese Journal of Allergology
 
 Volume: 71 Issue: 9 Pages: 1122-1128
- DOI
 10.15036/arerugi.71.1122
- ISSN
 0021-4884, 1347-7935
- Language
 Japanese
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23K24492
[Journal Article] Nasal polyp fibroblasts (NPFs)-derived exosomes are important for the release of vascular endothelial growth factor from cocultured eosinophils and NPFs2021
- Author(s)
  Shino Shimizu, IchiroTojima, Keigo Nakamura, Hiroyuki Arai, Hideaki Kouzaki, Takeshi Shimizu
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: - Issue: 3 Pages: 407-414
- DOI
  10.1016/j.anl.2021.10.002
- NAID
  120007172340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09843
[Journal Article] The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways2018
- Author(s)
  Shimizu Shino, Takezawa-Yasuoka Kumiko, Ogawa Takao, Tojima Ichiro, Kouzaki Hideaki, Shimizu Takeshi
- Journal Title
  
  Clinical Immunology
  
  Volume: 188 Pages: 1-6
- DOI
  10.1016/j.clim.2017.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20200, KAKENHI-PROJECT-16K11212
[Journal Article] Thrombin and activated coagulation factor X stimulate the release of cytokines and fibronectin from nasal polyp fibroblasts via protease-activated receptors2017
- Author(s)
  Shimizu S, Tojima I, Takezawa K, Matsumoto K, Kouzaki H, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 31 Issue: 1 Pages: 13-18
- DOI
  10.2500/ajra.2017.31.4400
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462581, KAKENHI-PROJECT-16K11212, KAKENHI-PROJECT-15K20200
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor(EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelialium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, Shimizu T
- Journal Title
  
  Ａｍ　Ｊ　Ｒｈｉｎｏｌ　Ａｌｌｅｒｇｙ
  
  Volume: ３０ Issue: 1 Pages: 1-6
- DOI
  10.2500/ajra.2016.30.4263
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] 難治性上気道炎症に対する新たな局所治療薬としてのEpidermal growth factor (EGF)受容体阻害薬の可能性2016
- Author(s)
  竹澤公美子、小河孝夫、清水志乃、清水猛史
- Journal Title
  
  耳鼻免疫アレルギー
  
  Volume: ３４ Pages: 1-7
- NAID
  130005141309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2016
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Journal Title
  
  Recent advances in thinosinusitis and nasal polyposis
  
  Volume: 0 Pages: 111-116
- Data Source
  KAKENHI-PROJECT-26462581
[Journal Article] Development of a method to measure Aβ42 in nasal cavity samples and its appilication in normal human volunteers.2014
- Author(s)
  Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamotyo T, Tooyama I
- Journal Title
  
  Journal of Brain Science
  
  Volume: 4 Pages: 5-23
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26640042
[Journal Article] Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in tissue remodeling2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezaka K, Tojima I, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Pages: 103-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] Eosinophil epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling2014
- Author(s)
  Shimizu S, Kouzaki H, Ogawa T, Takezawa K, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 28 Issue: 2 Pages: 103-109
- DOI
  10.2500/ajra.2014.28.4018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23592509, KAKENHI-PROJECT-24791770, KAKENHI-PROJECT-26462581
[Journal Article] The effect of heparin on antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats2013
- Author(s)
  Ogawa T, Shimizu S, Shimizu T.
- Journal Title
  
  Allergol Int
  
  Pages: 77-83
- NAID
  130004477169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791591
[Journal Article] 好酸球性副鼻腔炎の疑問-ニカワ様鼻汁の本態は何か?好酸球は何をしているのか?2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] 好酸球性副鼻腔炎の疑問－ニカワ様鼻汁の本態は何か？好酸球は何をしているのか？2012
- Author(s)
  清水猛史
- Journal Title
  
  耳鼻臨床
  
  Volume: 105 Pages: 803-812
- NAID
  10031012193
- Data Source
  KAKENHI-PROJECT-23592509
[Journal Article] 上気道炎症に対する新たな局所治療薬としてのヘパリンの可能性2011
- Author(s)
  小河孝夫、清水志乃、戸嶋一郎、神前英明、清水猛史
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
  
  Volume: 29 Pages: 221-227
- NAID
  10030647004
- URL
  http://mol.medicalonline.jp/library/archive/search?jo=ch6menek&ye=2011&vo=29&nu=3&st=221
- Data Source
  KAKENHI-PROJECT-22791591
[Journal Article] Role of thrombin in chronic rhinosinusitis-associated tissue remodeling.2011
- Author(s)
  Shimizu S, Gabazza EC, Ogawa T, Tojima I, Hoshi E, Kouzaki H, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 25 Issue: 1 Pages: 7-11
- DOI
  10.2500/ajra.2011.25.3535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791591
[Journal Article] Role of thrombin in chronic rhinosinusitis-associated tissue remodeling2011
- Author(s)
  Shino Shimizu, et.al.
- Journal Title
  
  American Journal of Rhinology & Allergy
  
  Volume: 25-1 Pages: 7-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791591
[Journal Article] Heparin inhibits mucus hypersecretion in airway epithelial cells2011
- Author(s)
  Ogawa T, Shimizu S, Tojima I, Kouzaki H, Shimizu T
- Journal Title
  
  Am J Rhinol Allergy
  
  Volume: 25 Issue: 2 Pages: 69-74
- DOI
  10.2500/ajra.2011.25.3562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791591
[Journal Article] Role of Coagulation System in Inflammatory Responses of the Airways2010
- Author(s)
  清水志乃
- Journal Title
  
  Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)
  
  Volume: 49 Issue: 1 Pages: 1-7
- DOI
  10.7248/jjrhi.49.1
- NAID
  130004546007
- ISSN
  0910-9153, 1883-7077
- Language
  English
- Data Source
  KAKENHI-PROJECT-22791591
[Patent] 採取パーツと採取パーツを備える生体組織採取具2014
- Inventor(s)
  南條俊文、福原崇臣、濱中健一、遠山育夫、清水志乃
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-011126
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Patent] 生体組織採取器具2014
- Inventor(s)
  森分優太、篠原紀行、南條俊文、濱中健一、遠山育夫、清水志乃等
- Industrial Property Rights Holder
  パナソニックヘルスケア株式会社
- Industrial Property Rights Type
  意匠
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462663
[Presentation] ダニ舌下免疫療法115例の3年間の治療成績2024
- Author(s)
  湯田厚司、小川由起子、神前英明、清水猛史
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] New understanding of the immune mechanism of sublingual innunotherapy2024
- Author(s)
  Shimizu T
- Organizer
  日韓耳鼻咽喉科学会2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] A Transcription Factor Blimp1 in CD4 + T cells Promotes Type 2 Immune Responses in the Lungs While it Suppresses IgE Antibody Production in Mice2023
- Author(s)
  Koji Matsumoto, HIrohito Kita, Takeshi Shimizu
- Organizer
  IFOS DUBAI ENT WORLD CONGRESS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 非ヒト霊長類の嗅上皮から嗅球におけるSARS-CoV-2感染の病態2023
- Author(s)
  清水志乃、仲山美沙子、石垣宏仁、Thanh Cong Nguyen、北川善紀、伊藤靖、清水猛史
- Organizer
  第3回日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] SARS-CoV-2-induced inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates.2023
- Author(s)
  Takeshi Shimizu, Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Yasushi Itoh
- Organizer
  ISIAN2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] Role of infiltrating eosinophils in pathophysiology of CRS2023
- Author(s)
  Takeshi Shimizu
- Organizer
  IFOS DUBAI ENT WORLD CONGRESS 2023
- Invited
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] ダニ舌下免疫療法における濾胞性制御性T細胞の増加と臨床症状スコアの関連について2023
- Author(s)
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Organizer
  第71回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] SARS-CoV-2感染非ヒト霊長類における嗅上皮の変化と嗅神経を介した頭蓋内感染の可能性2023
- Author(s)
  清水猛史、清水志乃、仲山美沙子、石垣宏仁、Nguyen Thanh Cong、北川善紀、伊藤　靖
- Organizer
  第40回耳鼻咽喉科ニューロサイエンス研究会
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] 上気道炎症の病態と制御ー臨床における疑問に挑むー2023
- Author(s)
  清水猛史
- Organizer
  第124回日本耳鼻咽喉科頭頸部外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 舌下免疫療法における濾胞性制御性T細胞の変化と臨床症状スコアについて2022
- Author(s)
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Organizer
  村尾拓哉、神前英明、湯田厚司、清水猛史
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] 抗原特異的IgE抗体の抗原親和性からみた舌下免疫療法の新たな作用機序2022
- Author(s)
  中村圭吾、神前英明、坂井利香、湯田厚司、木戸博、清水猛史
- Organizer
  第2回日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] シダキュア錠1-3年目治療例の2022年治療成績とDual SLITが花粉期成績に及ぼす影響2022
- Author(s)
  湯田厚司、村尾拓哉、清水猛史
- Organizer
  第61回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-23K24492
[Presentation] SARS-CoV-2感染非ヒト霊長類の鼻腔組織の観察2022
- Author(s)
  清水志乃、仲山美沙子、石垣宏仁、Nguyen Thanh Cong、北川善紀、伊藤　靖、清水猛史
- Organizer
  第8回嗅覚冬のセミナー
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] サルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染についてサルにおける嗅上皮から嗅神経を介したSARS-CoV-2の頭蓋内感染について2022
- Author(s)
  清水志乃、仲山美沙子、石垣宏仁、Nguyen Thanh Cong、北川善紀、伊藤　靖、清水猛史
- Organizer
  第61回日本鼻科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] 鼻腔で検出されるアルツハイマー病特異的タンパク質について2022
- Author(s)
  清水志乃、松本晃治、赤津裕康、遠山育夫、清水猛史
- Organizer
  第39回耳鼻咽喉科ニューロサイエンス研究会
- Data Source
  KAKENHI-PROJECT-22K09704
[Presentation] 好酸球と鼻茸線維芽細胞の細胞間相互作用におけるエクソソームの役割について2021
- Author(s)
  清水志乃、戸嶋一郎、中村圭吾、神前英明、清水猛史
- Organizer
  第122回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K09843
[Presentation] 好酸球と鼻茸線維芽細胞の細胞間相互作用におけるエクソソームの役割について2021
- Author(s)
  清水志乃、戸嶋一郎、中村圭吾、神前英明、清水猛史
- Organizer
  日本鼻科学会
- Data Source
  KAKENHI-PROJECT-19K09843
[Presentation] Role of epithelial-derived cytokine, IL-33 in the pathogenesis of eosinophilic chronic rhinosinusitis2020
- Author(s)
  Kouzaki H, Shimizu S, ShimizuT
- Organizer
  American Academy of Otolaryngology-Head and Neck Surgery 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09317
[Presentation] Role of DUOX1 in the productions of epithelial-derived cytokines (IL-25, IL-33, TSLP) in eosinophilic chronic rhinosinusitis2019
- Author(s)
  Kouzaki H, Shimizu S, Shimizu T
- Organizer
  5th Rhinology Research Forum in Asia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09317
[Presentation] Role of innate immunity in the pathophysiology of eosinophilic chronic rhinosinusitis2018
- Author(s)
  Shimizu T, Shimizu S, Kouzaki H
- Organizer
  17th Koera-Japan joint meeting of Otorhinolaryngology-Head and Neck Surgery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09317
[Presentation] 上気道炎症における組織リモデリングとその制御2018
- Author(s)
  清水志乃
- Organizer
  第67回日本アレルギー学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of eosinophils in pathophysiology of eosinophilic CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  The 9th annual meeting of the Thai Rhinologic Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of infiltrating eosinophils in pathophysiology of CRS2017
- Author(s)
  Takeshi Shimizu
- Organizer
  Rhinology World Congress Hong Kong
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion and neutrophil infiltration in airway epithelium2016
- Author(s)
  Takezawa K, Ogawa T, Shimizu S, ShimizuT
- Organizer
  35th Congress of the International Society of Inflammation & Allergy of the Nose
- Place of Presentation
  Stockholm
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] 上気道炎症の組織リモデリングにおける凝固系因子と好酸球の役割2016
- Author(s)
  清水志乃
- Organizer
  日本鼻科学会
- Place of Presentation
  宇都宮市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16K11212
[Presentation] Role of EGFR in upperairway inflammation2016
- Author(s)
  Shimizu T
- Organizer
  2nd Rhinology Research Forum in Asia
- Place of Presentation
  Singapore
- Year and Date
  2016-12-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Eosinophil-epithelial cell interaactions stimulate the production of MUC5AC mucin and profibrotic cytokines through the transactivation of epidermal growth factor receptor in airway epithelial cells2015
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  16th World Congress of Rhinology
- Place of Presentation
  San Paulo, Brazil
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  17th Asian Research Symposium in Rhinology
- Place of Presentation
  Beijing, China
- Year and Date
  2015-04-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Our research interests and pathogenesis of eosinophilic chronic rhinosinusitis2015
- Author(s)
  Shimizu T
- Organizer
  11th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Korea
- Year and Date
  2015-10-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Interaction between coagulation and upper airway inflammation2015
- Author(s)
  Shimizu T
- Organizer
  13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-12-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] Tsissue remodeling of eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  Kyung Hee International Rhinologic Symposium 2013
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhunosinusitis2013
- Author(s)
  Shimizu T, Shimizu S, Ogawa T, Takezawa K, Kouzaki H
- Organizer
  VIIInternational Syumposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
- Place of Presentation
  Matsue
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 鼻副鼻腔における Tissue factor と Tissue factor pathway inhibitor2013
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  The 12th Taiwan-Japan conference on Otolaryngology-Head and Neck Surgery
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 鼻副鼻腔におけるTissue factorとTissue factor pathway inhibitor2013
- Author(s)
  清水志乃
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
 Shimizu T, Shimizu S
- Organizer
 The 12^<th> Taiwan-Japan Conference on Otolarynggology-Head and Neck Surgery
- Place of Presentation
 Taipei
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  16th Asian Research Symposium in Rhinology
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Symposium, Up-to-date Research in CRS : Role of eosinophils in tissue remodeling of chronic rhinosinusitis2013
- Author(s)
 Shimizu T, Shimizu S
- Organizer
 16^<th> Asian Research Symposium in Rhinology
- Place of Presentation
 Tokyo
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] Role of coagulation factors and eosinophils in the pathogenesis of mucus hypersecretion in eosinophil-associated chronic rhinosinusitis2013
- Author(s)
  Shimizu T
- Organizer
  VII International symposium on recent advances in rhinosinusitis and nasal polyposis
- Place of Presentation
  Matsue, Shimane
- Invited
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイニン分泌における好酸球と上皮細胞の交互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、清水猛史
- Organizer
  アレルギー・好酸球研究会2012
- Place of Presentation
  東京
- Year and Date
  2012-06-23
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 粘液・サイトカイン分泌における好酸球と上皮細胞の相互作用2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第31回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2012-04-07
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Eosinophil- epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
 Shimizu S, Kouzaki H, Shimizu T
- Organizer
 The 14^<th> Japan-Korea Joint Meeting of Otorhinolaryngology -Head and Neck Surgery
- Place of Presentation
 Kyoto
- Data Source
 KAKENHI-PROJECT-23592509
[Presentation] Eosinophil-epithelial cell interaction enhances mucin production and tissue remodeling2012
- Author(s)
  Shino Shimizu, Hideaki Kouzaki, Takeshi Shimizu
- Organizer
  The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  ソウル、大韓民国
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] 鼻副鼻腔における組織因子と組織因子経路インヒビター2012
- Author(s)
  清水志乃
- Organizer
  第62回日本アレルギー学会秋季学術大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Eosinophil-epithelial cell interaction enhances mucin production and tissue remodeling.2012
- Author(s)
  Shino Shimizu
- Organizer
  第14回日韓耳鼻咽喉科頭頸部外科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 鼻副鼻腔における組織因子と組織因子経路インヒビター2012
- Author(s)
  清水志乃、神前英明、清水猛史
- Organizer
  第62回日本耳鼻咽喉科免疫アレルギー学会秋季学術大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Heparin Inhibits Mucus Hypersecretion in Rat Nasal Epithelium2011
- Author(s)
  Takao Ogawa, Shino Shimizu, et.al.
- Organizer
  IRS & ISIAN 2011
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Role of Coagulation System in Tissue Remodeling of Sinonasal Inflammation2011
- Author(s)
  Takeshi Shimizu, Shino Shimizu, Takao Ogawa, Ichiro Tojima, Hideaki Kouzaki
- Organizer
  IRS & ISIAN 2011
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用2011
- Author(s)
  小河孝夫、清水志乃, その他
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大分全日空ホテルオアシスタワー(大分県)
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用2011
- Author(s)
  小河孝夫、清水志乃、戸嶋一郎、神前英明、清水猛史
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 凝固系因子と鼻副鼻腔リモデリング2011
- Author(s)
  清水志乃
- Organizer
  第14回滋賀県耳鼻咽喉科オープンセミナー
- Place of Presentation
  滋賀
- Year and Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] アレルギー性炎症によるラット鼻粘膜上皮の粘液産生と好酸球・好中球浸潤に対するヘパリンの抑制作用2011
- Author(s)
  小河孝夫、清水志乃, その他
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  東京
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 上気道炎症に対するヘパリンの抗炎症作用の検討2010
- Author(s)
  小河孝夫、清水志乃, その他
- Organizer
  第111回日本耳鼻咽喉科学会
- Place of Presentation
  仙台国際センター(宮城県)
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] In Vivo and in Vitro Effects of Heparin on Mucus Secretion in Airway Epithelial Cells2010
- Author(s)
  Shino Shimizu, et.al.
- Organizer
  The 13th Korea Japan Joint Meeting of Otorhinolaryngo logy-Head and Neck Surgery
- Place of Presentation
  Korea Seoul
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 気道炎症に対するヘパリンの抗炎症作用について2010
- Author(s)
  小河孝夫, 清水志乃, 戸嶋一郎, 柴山将之,瀬野悟史,星恵理子,清水猛史
- Organizer
  第28回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 上気道炎症に対するヘパリンの抗炎症作用の検討2010
- Author(s)
  小河孝夫、清水志乃、戸嶋一郎、柴山将之、瀬野悟史、清水猛史
- Organizer
  第111回日本耳鼻咽喉科学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] In vivo and in vitro effects of heparin on mucus secretion in airway epithelial cells2010
- Author(s)
  Shino Shimizu, Takao Ogawa, Ichiro Tojima, Takeshi Shimizu
- Organizer
  ERS&ISIAN
- Place of Presentation
  Geneva
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] Role of Coagulation System in Tissue Remodeling of Sinonasal Inflammation2010
- Author(s)
  Takeshi Shimizu, Shino Shimizu, et.al.
- Organizer
  The 13th Korea Japan Joint Meeting of Otorhinolaryngo logy-Head and Neck Surgery
- Place of Presentation
  Korea Seoul
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] In Vivo and in Vitro Effects of Heparin on Mucus Secretion in Airway Epithelial Cells2010
- Author(s)
  Shino Shimizu, Takao Ogawa, Ichiro Tojima, Takeshi Shimizu
- Organizer
  The 13th Korea Japan Joint Meeting of OtorhinolaryngologyHead and Neck Surgery
- Place of Presentation
  Korea
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] In vivo and in vitro effects of heparin on mucus secretion in airway epithelial cells.2010
- Author(s)
  Shino Shimizu, et.al.
- Organizer
  ERS&ISIAN 2010
- Place of Presentation
  Switzerland Geneve
- Data Source
  KAKENHI-PROJECT-22791591
[Presentation] 気道上皮細胞と好酸球の相互作用による粘液・サイトカイン分泌
- Author(s)
  清水志乃、小河孝夫、戸嶋一郎、神前英明、清水猛史
- Organizer
  第112回日本耳鼻咽喉科学会学術講演会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23592509
[Presentation] Mucus hypersecretion in the pathogenesis of upper airway inflammation; its merits and demerits
- Author(s)
  Shimizu T
- Organizer
  10th Research Symposium on Human Natural Defense System
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2014-10-18 – 2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-26462581
[Presentation] ROle of eosinophils in tissue remodeling of chronic rhinosinusitis
- Author(s)
  Shimizu T, Shimizu S
- Organizer
  32nd International Symposium of Infection & Allergy of Nose
- Place of Presentation
  Amsterdam, Kingdom of the Netherlands
- Year and Date
  2014-06-22 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-26462581

1. SHIMIZU TAKESHI (00206202)

# of Collaborated Projects: 5 results

# of Collaborated Products: 48 results
2. OGAWA Takao (90549908)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
3. TOJIMA Ichiro (80567347)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. KOUZAKI Hideaki (10402710)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. Akatsu Hiroyasu (00399734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Inoue Koichi (30339519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Michikawa Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Matsukawa Noriyuki (20305543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中多祐介 (80794958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松本晃治 (40750138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 中村圭吾 (50848380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 川北憲人 (50915121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 新井宏幸 (60816627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 湯田厚司 (80293778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
16. 竹澤公美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Shino 清水 志乃

SHIMIZU Shino 清水 志乃

Research Projects

Research Products

Co-Researchers

カニクイザルのSARS-Cov-2感染モデルを利用した嗅覚障害発症機序の解明Principal Investigator

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New understanding of the immune mechanism of sublingual immunotherapy

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Development of new diagnostic methods by extracellular vesicles in nasal lavage fluidsPrincipal Investigator

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Role of innate immunity in the pathogenesis of eosinophilic chronic rhinosinusitis: Alermin and IL-18

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Elucidation of the pathophysiology of eosinophilic chronic rhinosinusitis focusing on the action of coagulation factors on fibroblasts and eosinophilsPrincipal Investigator

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Tissue remodering of eosinophilic chronic rhinosinusitis

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Determinations of nasal biomarkers for dementia and development of a novel diagnostic method for Alzheimer's disease using nasal samples.

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Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's DiseasePrincipal Investigator

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Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling

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Role of coagulation factors in the eosinophilic inflammation of upper airwaysPrincipal Investigator

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[Book] Recent Advances in Rhinosinusitis and Nasal Polyposis2015

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[Journal Article] SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates2024

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[Journal Article] Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites2023

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[Journal Article] CLINICAL EFFICASY OF HOUSE DUST MITE SUBLINGUAL IMMUNOTHERAPY WITH MITICURE<sup>®</sup> TABLETS IN 115 PAITENTS FOR 3 YEARS2023

Shimizu Shino 清水志乃

SHIMIZU Shino 清水志乃