Boku Narikazu 朴成和

… Alternative Names

BOKU Narikazu 朴成和

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Researcher Number	50505948
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 教授 2025: 聖マリアンナ医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京大学, 医科学研究所, 教授 2020: 国立研究開発法人国立がん研究センター, 中央病院, 科長 2015 – 2017: 国立研究開発法人国立がん研究センター, 中央病院, 科長 2015: 国立研究開発法人国立がん研究センター, その他部局等, その他 2014: 国立研究開発法人国立がん研究センター, 中央病院, 科長(課長・グループリーダークラス) 2014: 国立がん研究センター中央病院, 副院長 2011 – 2013: 聖マリアンナ医科大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Epidemiology and preventive medicine / Tumor biology / Clinical oncology / Tumor diagnosis
Keywords	Principal Investigator 抗PD-1抗体 / PD-1 / PD-L1 / S-1 / 5-FU / 胃癌 Except Principal Investigator 乳癌 / 免疫誘導 / 免疫誘導性細胞死 / がん治療 … More / 細胞死 / がん / 麻疹ウイルス / 腫瘍溶解性ウイルス / リン酸プロテオミクス / リン酸化プロテオミクス / 生検組織 / 精密医療 / がん多様性 / リン酸化プロテオーム解析 / レセプト分析 / 糖尿病 / DNA損傷 / BARD1 / BRCA1 / 治療 / 肺がん / スキルス胃がん / チロシンキナーゼ / 分子標的治療 / 非癌遺伝子依存性 / 癌化学療法 / 合成致死性 / DNA修復 Less

フッ化ピリミジン製剤による胃癌PD-L1発現制御機序の解明とPD-1抗体耐性の克服Principal Investigator
- Principal Investigator
  
  朴成和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
癌治療用組換え麻疹ウイルスによる細胞死メカニズムと免疫誘導性の解析
- Principal Investigator
  
  藤幸知子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Elucidation of cancer diversity mechanism by analysis of phosphorylation signal using biopsy tissue and application to precision medicine
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Research on new related diseases and conditions of diabetes mellitus using a large-scale database of medical claims data and data from health checkups
- Principal Investigator
  
  NODA MITSUHIKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Saitama Medical University
  National Center for Global Health and Medicine
Functional analysis of BRCA1 as the molecular basis of breast cancer therapy
- Principal Investigator
  
  OHTA Tomohiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  St. Marianna University School of Medicine
Cancer therapeutic target identification by comprehensive kinase profiling
- Principal Investigator
  
  KOH Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Wakayama Medical University
  Shizuoka Cancer Center Research Institute
Research on the breast cancer chemotherapy targeting synthetic lethality caused by the factors in the DNA damage repair pathways.
- Principal Investigator
  
  OHTA Tomohiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnosis
- Research Institution
  St. Marianna University School of Medicine

All 2023 2022 2020 2013 2011

All Journal Article Presentation

[Journal Article] Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines.2023
- Author(s)
  Nojima, Y., Aoki, M., Re, S., Hirano, H., Abe, Y., Narumi, R., Muraoka, S., Shoji, H., Honda, K., Tomonaga, T., Mizuguchi, K., Boku, N., and Adachi, J.
- Journal Title
  
  Comput Struct Biotechnol J
  
  Volume: 21 Pages: 2172-2187
- DOI
  10.1016/j.csbj.2023.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03544, KAKENHI-PROJECT-20K07333, KAKENHI-PROJECT-20K15422, KAKENHI-PROJECT-20K17069, KAKENHI-PROJECT-23K20389, KAKENHI-PROJECT-22K08068
[Journal Article] Association of probiotic use with nivolumab effectiveness against various cancers: A multicenter retrospective cohort study2023
- Author(s)
  Arai Junya、Niikura Ryota、Hayakawa Yoku、Suzuki Nobumi、Honda Tetsuro、Okamura Takuma、Hasatani Kenkei、Yoshida Naohiro、Nishida Tsutomu、Sumiyoshi Tetsuya、Kiyotoki Shu、Ikeya Takashi、Arai Masahiro、Boku Narikazu、Fujishiro Mitsuhiro
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 16 Pages: 16876-16880
- DOI
  10.1002/cam4.6313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08028, KAKENHI-PROJECT-23K07393, KAKENHI-PROJECT-23K07448, KAKENHI-PROJECT-21K07976
[Journal Article] Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer2022
- Author(s)
  Hirano H, Abe Y, Nojima Y, Aoki M, Shoji H, Isoyama J, Honda K, Boku N, Mizuguchi K, Tomonaga T, Adachi J.
- Journal Title
  
  Sci Rep.
  
  Volume: 12(1) Issue: 1 Pages: 4419-4419
- DOI
  10.1038/s41598-022-08430-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08432, KAKENHI-PROJECT-20H03544, KAKENHI-PROJECT-20H03749, KAKENHI-PROJECT-20K15422, KAKENHI-PROJECT-20K07333, KAKENHI-PROJECT-20K17069, KAKENHI-PROJECT-23K20389, KAKENHI-PROJECT-19H03856
[Journal Article] Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.2020
- Author(s)
  Abe Y, Hirano H, Shoji H, Tada A, Isoyama J, Kakudo A, Gunji D, Honda K, Boku N, Adachi J, Tomonaga T.
- Journal Title
  
  Theranostics
  
  Volume: 10（5） Issue: 5 Pages: 2115-2129
- DOI
  10.7150/thno.37623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08432, KAKENHI-PROJECT-20H03544, KAKENHI-PROJECT-19H03856
[Journal Article] Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum : WJOG 4007 trial2013
- Author(s)
  Hironaka S, Ueda S, Yasui H, Nishina T, Tsuda M, Tsumura T, Sugimoto N, Shimodaira H, Tokunaga S, Moriwaki T, Esaki T, Nagase M, Fujitani K, Yamaguchi K, Ura T, Hamamoto Y, Morita S, Okamoto I, Boku N, Hyodo I
- Journal Title
  
  J Clin Oncol
  
  Volume: 31(35) Issue: 35 Pages: 4438-44
- DOI
  10.1200/jco.2012.48.5805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300358
[Journal Article] HERC2 Interacts with Claspin and regulates DNA origin firingandr eplication fork progression2011
- Author(s)
  Izawa N, Wu W, Sato K, Nishikawa H, Kato A, Boku N, Itoh F, Ohta T
- Journal Title
  
  Cancer Research
  
  Volume: Volume 71 Issue: 17 Pages: 5621-5625
- DOI
  10.1158/0008-5472.can-11-0385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710053, KAKENHI-PUBLICLY-23131514, KAKENHI-PROJECT-23300358, KAKENHI-PROJECT-23590348
[Presentation] Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.2020
- Author(s)
  Shoji H, Abe Y, Hirano H, Adachi J, Aoki M, Honda K, Boku N, Tomonaga T.
- Organizer
  AACR Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03544
[Presentation] Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.2020
- Author(s)
  Shoji H, Abe Y, Hirano H, Adachi J, Aoki M, Honda K, Boku N, Tomonaga T
- Organizer
  2020 ASMS Reboot
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03544

1. OHTA Tomohiko (60233136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TSUGAWA Koichiro (60313657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAKADA Shinichiro (70548528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KOH Yasuhiro (80426519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAMAMOTO Nobuyuki (60298966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAJIMA Takashi (20124422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KONDO Haruhiko (60399590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NODA MITSUHIKO (90237850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHE Kazuhiko (40221121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Tomonaga Takeshi (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 櫻井孝 (50335444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 古川壽亮 (90275123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 竹内靖博 (50202164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 磯博康 (50223053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 後藤温 (80644822)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 足立淳 (20437255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 長山聡 (70362499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐藤友美 (10333353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 藤幸知子 (50610630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 森藤可南子 (90867524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐藤宏樹 (50418654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 鈴木伸三 (30723746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. YASUI Hirofumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ENDO Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HIKIMA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHOJI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
27. KATO Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 本田一文

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 庄司広和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Boku Narikazu 朴 成和

BOKU Narikazu 朴 成和

Research Projects

Research Products

Co-Researchers

フッ化ピリミジン製剤による胃癌PD-L1発現制御機序の解明とPD-1抗体耐性の克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌治療用組換え麻疹ウイルスによる細胞死メカニズムと免疫誘導性の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of cancer diversity mechanism by analysis of phosphorylation signal using biopsy tissue and application to precision medicine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on new related diseases and conditions of diabetes mellitus using a large-scale database of medical claims data and data from health checkups

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of BRCA1 as the molecular basis of breast cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cancer therapeutic target identification by comprehensive kinase profiling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the breast cancer chemotherapy targeting synthetic lethality caused by the factors in the DNA damage repair pathways.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Integration of pharmacoproteomic and computational approaches reveals the cellular signal transduction pathways affected by apatinib in gastric cancer cell lines.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of probiotic use with nivolumab effectiveness against various cancers: A multicenter retrospective cohort study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum : WJOG 4007 trial2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HERC2 Interacts with Claspin and regulates DNA origin firingandr eplication fork progression2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] Comprehensive characterization of the phosphoproteome of gastric cancer from endoscopic biopsy specimens.2020

Author(s)

Organizer

Boku Narikazu 朴成和

BOKU Narikazu 朴成和