INOUE ASUKA 井上飛鳥

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INOUE Asuka 井上飛鳥

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Researcher Number	50525813
Other IDs
Affiliation (Current)	2025: 京都大学, 薬学研究科, 教授 2025: 東北大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 京都大学, 薬学研究科, 教授 2021 – 2024: 東北大学, 薬学研究科, 教授 2016 – 2021: 東北大学, 薬学研究科, 准教授 2014 – 2015: 東北大学, 薬学研究科(研究院), 助教 2012 – 2013: 東北大学, 薬学研究科(研究院), 助手 2009 – 2010: Tohoku University, 大学院・薬学研究科, 助手
Review Section/Research Field	Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy / Transformative Research Areas, Section (II) / Biological Sciences / Functional biochemistry Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Broad Section G / Transformative Research Areas, Section (II) / Basic Section 43030:Functional biochemistry-related / Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator GPCR / シグナル伝達 / リゾリン脂質 / TRPチャネル / Gタンパク質共役型受容体 / LPA / TGFα / リゾホスファチジン酸 / 作動薬 / タンパク質分解 … More / DREADD / G12 / バイアス / 計算科学 / オピオイド受容体 / オピオイド / 薬理学 / 薬学 / シグナル / バイアスリガンド / 生理活性 / 脂質 / TGFα切断アッセイ / Gタンパク質共役型受容体（GPCR） / リゾホスファチジン酸（LPA） / 精巣 / 脂質メディエーター / 雄性生殖 / 雄性生殖器 / Lysosphatidic acid (LPA) / GPR174 / P2Y10 / オーファン / エクトドメイン切断 / HEK293 / CRISPR / リゾホスファチジルセリン / TGFalpha / 体毛形成 / 毛根 / 産生酵素 / 受容体 / 毛包 … More Except Principal Investigator GPCR / オピオイド受容体 / リン脂質 / リゾリン脂質 / 構造シグナル相関研究 / Gバイアス型リガンド / アルカロイド / オピオイド作動薬 / 鎮痛活性 / パーシャルアゴニスト / バイアス型アゴニスト / インドール / 構造活性相関研究 / ミトラガイナアルカロイド / クライオ電子顕微鏡 / 生体膜 / 作動薬 / 神経科学 / 構造生物学 / オピオイド / 創薬化学 / 神経回路 / クライオ電子顕微鏡単粒子解析 / シグナル伝達 / Gタンパク質共役型受容体 / Gタンパク質共役受容体 / 質量分析 / すい臓がん / イノシトールリン脂質 / オートタキシン / 脂質メディエーター / グリア / リゾホスファチジン酸１受容体 / うつ病バイオマーカー / DHA-LPA / 抗うつ薬創薬 / LPA受容体 / 抗うつ薬受容体 / バイオマーカー / LPA1受容体 / 栄養療法 / 創薬 / 抗うつ薬 / リゾフォスファチジン酸受容体１ / リゾフォスファチジン酸 / リゾリン脂質代謝 / うつ病 Less

G13共役型デザイナーGPCRの開発と遺伝薬理学論の概念実証Principal Investigator
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyoto University
受容体分解の制御機構解明から開拓する分解誘導薬の合理的設計論Principal Investigator
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyoto University
ミトラガイナアルカロイドを基盤とする副作用を示さないオピオイド作動性鎮痛薬の創製
- Principal Investigator
  
  石川勇人
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University
Multi-scale platform for untangling physiological complexity
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
Identification of pharmacologically relevant signaling pathways at opioid receptorsPrincipal Investigator
- Principal Investigator
  
  Inoue Asuka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Tohoku University
Manipulation of G12/13 signaling and and drug development strategyPrincipal Investigator
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Structural dynamics of GPCR in cells
- Principal Investigator
  
  濡木理
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  The University of Tokyo
A study of novel lysophospholipids and exploration of their targets
- Principal Investigator
  
  Hasegawa Junya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)
- Principal Investigator
  
  Takebayashi Minoru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kumamoto University
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Signaling basis of GPCR-acting drugs and their therapeutic mechanismsPrincipal Investigator
- Principal Investigator
  
  Inoue Asuka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Understanding lipid-regulated TRP channels and their roles in thermal biologyPrincipal Investigator
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
A role of lysophosphatidic acid signaling in male organPrincipal Investigator
- Principal Investigator
  
  Asuka Inoue
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Screening for ligands of G protein-coupled receptors using the newly developed TGFalpha shedding assayPrincipal Investigator
- Principal Investigator
  
  INOUE Asuka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Lysophosphatidic acid regulates hair follicle developmentPrincipal Investigator
- Principal Investigator
  
  INOUE Asuka
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University

[Book] リゾホスファチジン酸(LPA)の生理的機能」(総説)、医学のあゆみ,生命を支える脂質−最新の研究と臨床2482014
- Author(s)
  井上飛鳥、青木淳賢
- Data Source
  KAKENHI-PROJECT-24790064
[Book] 【最新生理活性脂質研究-実験手法、基礎的知識とその応用-】(第1章)技術編TGFα切断を用いたGPCR活性化の新しい検出法(解説)2013
- Author(s)
  井上飛鳥
- Data Source
  KAKENHI-PROJECT-24790064
[Book] TGFα切断を用いたGPCRの高感度・高精度な活性化検出法」(解説)、実験医学312013
- Author(s)
  井上飛鳥、青木淳賢
- Data Source
  KAKENHI-PROJECT-24790064
[Book] 「【最新生理活性脂質研究-実験手法、基礎的知識とその応用-】(第1章)技術編TGFα切断を用いたGPCR活性化の新しい検出法」(解説)、遺伝子医学MOOK 242013
- Author(s)
  井上飛鳥、青木淳賢
- Data Source
  KAKENHI-PROJECT-24790064
[Journal Article] Basal interaction of the orphan receptor GPR101 with arrestins leads to constitutive internalization2024
- Author(s)
  Abboud Dayana、Abboud Clauda、Inoue Asuka、Twizere Jean-Claude、Hanson Julien
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 220 Pages: 116013-116013
- DOI
  10.1016/j.bcp.2023.116013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] GPCR signaling bias: an emerging framework for opioid drug development2024
- Author(s)
  Kise Ryoji、Inoue Asuka
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 175 Issue: 4 Pages: 367-376
- DOI
  10.1093/jb/mvae013
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins2024
- Author(s)
  Moller Thor C.、Moo Ee Von、Inoue Asuka、Pedersen Mie F.、Brauner-Osborne Hans
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1871 Issue: 1 Pages: 119584-119584
- DOI
  10.1016/j.bbamcr.2023.119584
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor2024
- Author(s)
  Hoshina Motoki、Ojima Shiomi、Kawasaki Atsushi、Doi Kosuke、Ohta Satoshi、Inoue Asuka、Murayama Hiroshi
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 528 Pages: 113655-113655
- DOI
  10.1016/j.jim.2024.113655
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression.2024
- Author(s)
  Kajitani, N., Okada-Tsuchioka, M., Inoue, A., Miyano, K., Masuda, T., Boku, S., Iwamoto, K., Ohtsuki, S., Uezono, Y., Aoki, J., Takebayashi, M.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 49 Issue: 3 Pages: 561-572
- DOI
  10.1038/s41386-023-01727-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07750, KAKENHI-PROJECT-21K07501, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K27530
[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024
- Author(s)
  Imamura Kayo、Akagi Ken-Ichi、Miyanoiri Yohei、Tsujimoto Hirokazu、Hirokawa Takatsugu、Ashida Hideo、Murakami Kaori、Inoue Asuka、Suno Ryoji、Ikegami Takahisa、Sekiyama Naotaka、Iwata So、Kobayashi Takuya、Tochio Hidehito
- Journal Title
  
  Structure
  
  Volume: 32 Issue: 3 Pages: 352-361
- DOI
  10.1016/j.str.2023.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05653, KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PLANNED-22H05090, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428
[Journal Article] Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq2024
- Author(s)
  Ham Donghee、Inoue Asuka、Xu Jun、Du Yang、Chung Ka Young
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 362-362
- DOI
  10.1038/s42003-024-06056-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation2024
- Author(s)
  McNeill Samantha M.、Lu Jessica、Marion C. Carino Carlo、Inoue Asuka、Zhao Peishen、Sexton Patrick M.、Wootten Denise
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 222 Pages: 116119-116119
- DOI
  10.1016/j.bcp.2024.116119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics2024
- Author(s)
  Zecchin Davide、Knopfel Nicole、Gluck Anna K.、Stevenson Mark、Sauvadet Aimie、Polubothu Satyamaanasa、Barberan-Martin Sara、Michailidis Fanourios、Bryant Dale、Inoue Asuka、Lines Kate E.、Hannan Fadil M.、Semple Robert K.、Thakker Rajesh V.、Kinsler Veronica A.
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 144 Issue: 4 Pages: 811-819.e4
- DOI
  10.1016/j.jid.2023.08.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor2024
- Author(s)
  Jayakody Tharindunee、Inoue Asuka、Kannan Srinivasaraghavan、Nakamura Gaku、Kawakami Kouki、Mendis Krishan、Nguyen Thanh-Binh、Li Jianguo、Herr Deron R.、Verma Chandra S.、Dawe Gavin S.
- Journal Title
  
  Science Signaling
  
  Volume: 17 Issue: 823
- DOI
  10.1126/scisignal.abl5880
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural and functional characterization of the endogenous agonist for orphan receptor GPR32024
- Author(s)
  Chen Geng、Staffen Nico、Wu Zhangsong、Xu Xinyu、Pan Jinheng、Inoue Asuka、Shi Tingyi、Gmeiner Peter、Du Yang、Xu Jun
- Journal Title
  
  Cell Research
  
  Volume: 34 Issue: 3 Pages: 262-265
- DOI
  10.1038/s41422-023-00919-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor2023
- Author(s)
  Burghi Valeria、Paradis Justine S.、Officer Adam、Adame-Garcia Sendi Rafael、Wu Xingyu、Matthees Edda S.F.、Barsi-Rhyne Benjamin、Ramms Dana J.、Clubb Lauren、Acosta Monica、Tamayo Pablo、Bouvier Michel、Inoue Asuka、von Zastrow Mark、Hoffmann Carsten、Gutkind J. Silvio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 11 Pages: 105293-105293
- DOI
  10.1016/j.jbc.2023.105293
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor2023
- Author(s)
  Xu Jun、Wang Qinggong、Hubner Harald、Hu Yunfei、Niu Xiaogang、Wang Haoqing、Maeda Shoji、Inoue Asuka、Tao Yuyong、Gmeiner Peter、Du Yang、Jin Changwen、Kobilka Brian K.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 376-376
- DOI
  10.1038/s41467-022-35726-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural basis of CXC chemokine receptor 1 ligand binding and activation2023
- Author(s)
  Ishimoto Naito、Park Jae-Hyun、Kawakami Kouki、Tajiri Michiko、Mizutani Kenji、Akashi Satoko、Tame Jeremy R. H.、Inoue Asuka、Park Sam-Yong
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4107-4107
- DOI
  10.1038/s41467-023-39799-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19236, KAKENHI-PLANNED-19H05774, KAKENHI-PLANNED-19H05779, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H02449
[Journal Article] Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML3142023
- Author(s)
  Bumbak Fabian、Bower James B.、Zemmer Skylar C.、Inoue Asuka、Pons Miquel、Paniagua Juan Carlos、Yan Fei、Ford James、Wu Hongwei、Robson Scott A.、Bathgate Ross A. D.、Scott Daniel J.、Gooley Paul R.、Ziarek Joshua J.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 3328-3328
- DOI
  10.1038/s41467-023-38894-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity2023
- Author(s)
  Yin Han、Inoue Asuka、Ma Zhengxiong、Zhu Xinyan、Xia Ruixue、Xu Zhenmei、Wang Na、Duan Yaning、Zhang Anqi、Guo Changyou、He Yuanzheng
- Journal Title
  
  Cell Research
  
  Volume: 33 Issue: 8 Pages: 644-647
- DOI
  10.1038/s41422-023-00835-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Insights into distinct signaling profiles of the μOR activated by diverse agonists2023
- Author(s)
  Qu Qianhui、Huang Weijiao、Aydin Deniz、Paggi Joseph M.、Seven Alpay B.、Wang Haoqing、Chakraborty Soumen、Che Tao、DiBerto Jeffrey F.、Robertson Michael J.、Inoue Asuka、Suomivuori Carl-Mikael、Roth Bryan L.、Majumdar Susruta、Dror Ron O.、Kobilka Brian K.、Skiniotis Georgios
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 19 Issue: 4 Pages: 423-430
- DOI
  10.1038/s41589-022-01208-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor2023
- Author(s)
  Heng Jie、Hu Yunfei、Perez-Hernandez Guillermo、Inoue Asuka、Zhao Jiawei、Ma Xiuyan、Sun Xiaoou、Kawakami Kouki、Ikuta Tatsuya、Ding Jienv、Yang Yujie、Zhang Lujia、Peng Sijia、Niu Xiaogang、Li Hongwei、Guixa-Gonzalez Ramon、Jin Changwen、Hildebrand Peter W.、Chen Chunlai、Kobilka Brian K.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2005-2005
- DOI
  10.1038/s41467-023-37233-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors2023
- Author(s)
  Voss Jan H.、Crusemann Max、Bartling Christian R.O.、Kehraus Stefan、Inoue Asuka、Konig Gabriele M.、Stromgaard Kristian、Muller Christa E.
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106492-106492
- DOI
  10.1016/j.isci.2023.106492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs2023
- Author(s)
  Ono Yuki、Kawakami Kouki、Nakamura Gaku、Ishida Satoru、Aoki Junken、Inoue Asuka
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 112-112
- DOI
  10.1038/s42003-023-04465-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J20669
[Journal Article] Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 22023
- Author(s)
  Park Jae-Hyun、Kawakami Kouki、Ishimoto Naito、Ikuta Tatsuya、Ohki Mio、Ekimoto Toru、Ikeguchi Mitsunori、Lee Dong-Sun、Lee Young-Ho、Tame Jeremy R. H.、Inoue Asuka、Park Sam-Yong
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 7150-7150
- DOI
  10.1038/s41467-023-42764-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05779, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H02449
[Journal Article] Class B1 GPCR activation by an intracellular agonist2023
- Author(s)
  Kobayashi Kazuhiro、Kawakami Kouki、Kusakizako Tsukasa、Tomita Atsuhiro、Nishimura Michihiro、Sawada Kazuhiro、Okamoto Hiroyuki H.、Hiratsuka Suzune、Nakamura Gaku、Kuwabara Riku、Noda Hiroshi、Muramatsu Hiroyasu、Shimizu Masaru、Taguchi Tomohiko、Inoue Asuka、Murata Takeshi、Nureki Osamu
- Journal Title
  
  Nature
  
  Volume: 618 Issue: 7967 Pages: 1085-1093
- DOI
  10.1038/s41586-023-06169-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15072, KAKENHI-PROJECT-22KJ1017, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach2023
- Author(s)
  Matic Marin、Miglionico Pasquale、Tatsumi Manae、Inoue Asuka、Raimondi Francesco
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4361-4361
- DOI
  10.1038/s41467-023-40045-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ0224, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels2023
- Author(s)
  Tatsumi Manae、Kishi Takayuki、Ishida Satoru、Kawana Hiroki、Uwamizu Akiharu、Ono Yuki、Kawakami Kouki、Aoki Junken、Inoue Asuka
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 1 Pages: e0280448-e0280448
- DOI
  10.1371/journal.pone.0280448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15273, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J20669, KAKENHI-PROJECT-22KJ0224
[Journal Article] Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization2023
- Author(s)
  Kjaer Viktoria M.S.、Daugvilaite Viktorija、Stepniewski Tomasz M.、Madsen Christian M.、Jorgensen Astrid S.、Bhuskute Kaustubh R.、Inoue Asuka、Ulven Trond、Benned-Jensen Tau、Hjorth Siv A.、Hjorto Gertrud M.、Moo Ee Von、Selent Jana、Rosenkilde Mette M.
- Journal Title
  
  Science Signaling
  
  Volume: 16 Issue: 779
- DOI
  10.1126/scisignal.abl4283
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation2023
- Author(s)
  Liang Jiale、Inoue Asuka、Ikuta Tatsuya、Xia Ruixue、Wang Na、Kawakami Kouki、Xu Zhenmei、Qian Yu、Zhu Xinyan、Zhang Anqi、Guo Changyou、Huang Zhiwei、He Yuanzheng
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1012-1012
- DOI
  10.1038/s41467-023-36575-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Chemogenetic activation of G12 signaling enhances adipose tissue browning2023
- Author(s)
  Ono Y, Ito R, Arai K, Singh G, Saitoh T, Russell RB, Raimondi F, Aoki J, Sakai J, Inoue A.
- Journal Title
  
  Signal Transduction and Targeted Therapy
  
  Volume: 8 Issue: 1 Pages: 307-307
- DOI
  10.1038/s41392-023-01524-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18411, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H04826
[Journal Article] Molecular mechanism of fatty acid activation of FFAR12023
- Author(s)
  Kumari Punita、Inoue Asuka、Chapman Karen、Lian Peng、Rosenbaum Daniel M.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 22
- DOI
  10.1073/pnas.2219569120
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023
- Author(s)
  Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 8 Pages: 5453-5464
- DOI
  10.1021/acs.jmedchem.2c01773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20H03361
[Journal Article] Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system2023
- Author(s)
  Sarma Parishmita、Carino Carlo Marion C.、Seetharama Deeksha、Pandey Shubhi、Dwivedi-Agnihotri Hemlata、Rui Xue、Cao Yubo、Kawakami Kouki、Kumari Poonam、Chen Yu-Chih、Luker Kathryn E.、Yadav Prem N.、Luker Gary D.、Laporte Stephane A.、Chen Xin、Inoue Asuka、Shukla Arun K.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 4808-4808
- DOI
  10.1038/s41467-023-40482-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction2023
- Author(s)
  Ogawa Akiko、Ohira Seiya、Kato Yuri、Ikuta Tatsuya、Yanagida Shota、Mi Xinya、Ishii Yukina、Kanda Yasunari、Nishida Motohiro、Inoue Asuka、Wei Fan-Yan
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-023-04888-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18088, KAKENHI-PROJECT-22K19395, KAKENHI-PUBLICLY-22H04628, KAKENHI-PLANNED-21H05269, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-23K24075
[Journal Article] Eriodictyol and thymonin act as GPR35 agonists2023
- Author(s)
  Nakashima Fumie、Qi Loh Wei、Wakabayashi Mayuka、Shimomura Sayako、Hattori Hiroyuki、Kita Masaki、Inoue Asuka、Uchida Koji、Shibata Takahiro
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 12 Pages: 1514-1522
- DOI
  10.1093/bbb/zbad125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17374, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase2023
- Author(s)
  Furumura Sho、Ozaki Taro、Sugawara Akihiro、Morishita Yohei、Tsukada Kento、Ikuta Tatsuya、Inoue Asuka、Asai Teigo
- Journal Title
  
  Journal of Natural Products
  
  Volume: 86 Issue: 2 Pages: 398-405
- DOI
  10.1021/acs.jnatprod.2c01027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19095, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-23K24038
[Journal Article] Phenotypic evaluation of constitutive GPCR/G-protein signaling in zebrafish embryos and larvae2022
- Author(s)
  Shibata Takeaki、Kawakami Kouki、Kawana Hiroki、Aoki Junken、Inoue Asuka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 602 Pages: 70-76
- DOI
  10.1016/j.bbrc.2022.02.098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15273, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-2548902022
- Author(s)
  Randolph Clinita E.、Dwyer Morgan B.、Aumiller Jenna L.、Dixon Alethia J.、Inoue Asuka、Osei-Owusu Patrick、Wedegaertner Philip B.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 11 Pages: 102538-102538
- DOI
  10.1016/j.jbc.2022.102538
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody2022
- Author(s)
  Baidya Mithu、Chaturvedi Madhu、Dwivedi-Agnihotri Hemlata、Ranjan Ashutosh、Devost Dominic、Namkung Yoon、Stepniewski Tomasz Maciej、Pandey Shubhi、Baruah Minakshi、Panigrahi Bhanupriya、Sarma Parishmita、Yadav Manish K.、Maharana Jagannath、Banerjee Ramanuj、Kawakami Kouki、Inoue Asuka、et al
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4634-4634
- DOI
  10.1038/s41467-022-32386-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics2022
- Author(s)
  Janetzko John、Kise Ryoji、Barsi-Rhyne Benjamin、Siepe Dirk H.、Heydenreich Franziska M.、Kawakami Kouki、Masureel Matthieu、Maeda Shoji、Garcia K. Christopher、von Zastrow Mark、Inoue Asuka、Kobilka Brian K.
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 24 Pages: 4560-4573
- DOI
  10.1016/j.cell.2022.10.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Endogenous ligand recognition and structural transition of a human PTH receptor2022
- Author(s)
  Kobayashi Kazuhiro、Kawakami Kouki、Kusakizako Tsukasa、Miyauchi Hirotake、Tomita Atsuhiro、Kobayashi Kan、Shihoya Wataru、Yamashita Keitaro、Nishizawa Tomohiro、Kato Hideaki E.、Inoue Asuka、Nureki Osamu
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 18 Pages: 3468-3483
- DOI
  10.1016/j.molcel.2022.07.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15072, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J21820, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands2022
- Author(s)
  Iio Keita、Kutsumura Noriki、Nagumo Yasuyuki、Saitoh Tsuyoshi、Tokuda Akihisa、Hashimoto Kao、Yamamoto Naoshi、Kise Ryoji、Inoue Asuka、Mizoguchi Hirokazu、Nagase Hiroshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 56 Pages: 128485-128485
- DOI
  10.1016/j.bmcl.2021.128485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05710, KAKENHI-PUBLICLY-20H04763, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21K06602
[Journal Article] Common coupling map advances GPCR-G protein selectivity2022
- Author(s)
  Hauser Alexander S、Avet Charlotte、Normand Claire、Mancini Arturo、Inoue Asuka、Bouvier Michel、Gloriam David E
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.74107
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.2022
- Author(s)
  Suenaga R, Takemoto M, Inoue A, Ishitani R＊, Nureki O＊
- Journal Title
  
  PLoS. One.
  
  Volume: 17 Issue: 2 Pages: e0263296-e0263296
- DOI
  10.1371/journal.pone.0263296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H05037
[Journal Article] Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα <sub>i</sub> :β-arrestin complexes2022
- Author(s)
  Zheng Kevin、Smith Jeffrey S.、Eiger Dylan S.、Warman Anmol、Choi Issac、Honeycutt Christopher C.、Boldizsar Noelia、Gundry Jaimee N.、Pack Thomas F.、Inoue Asuka、Caron Marc G.、Rajagopal Sudarshan
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 726
- DOI
  10.1126/scisignal.abg5203
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04791
[Journal Article] Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface2022
- Author(s)
  Heo Yunseok、Ishimoto Naito、Jeon Ye-Eun、Yun Ji-Hye、Ohki Mio、Anraku Yuki、Sasaki Mina、Kita Shunsuke、Fukuhara Hideo、Ikuta Tatsuya、Kawakami Kouki、Inoue Asuka、Maenaka Katsumi、Tame Jeremy R. H.、Lee Weontae、Park Sam-Yong
- Journal Title
  
  PLOS Biology
  
  Volume: 20 Issue: 8 Pages: e3001714-e3001714
- DOI
  10.1371/journal.pbio.3001714
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H02449, KAKENHI-PLANNED-19H05779
[Journal Article] PRECOGx: exploring GPCR signaling mechanisms with deep protein representations2022
- Author(s)
  Matic Marin、Singh Gurdeep、Carli Francesco、De Oliveira Rosa Natalia、Miglionico Pasquale、Magni Lorenzo、Gutkind J Silvio、Russell Robert B、Inoue Asuka、Raimondi Francesco
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: W1 Pages: W598-W610
- DOI
  10.1093/nar/gkac426
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors2022
- Author(s)
  El Khamlichi Chayma、Reverchon Flora、Hervouet-Coste Nadege、Robin Elodie、Chopin Nicolas、Deau Emmanuel、Madouri Fahima、Guimpied Cyril、Colas Cyril、Menuet Arnaud、Inoue Asuka、Bojarski Andrzej J.、Guillaumet Gerald、Suzenet Franck、Reiter Eric、Morisset-Lopez Severine
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 21
- DOI
  10.1073/pnas.2118847119
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113
[Journal Article] Heterotrimeric Gq proteins?act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias2022
- Author(s)
  Kawakami Kouki、Yanagawa Masataka、Hiratsuka Suzune、Yoshida Misaki、Ono Yuki、Hiroshima Michio、Ueda Masahiro、Aoki Junken、Sako Yasushi、Inoue Asuka
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 870-870
- DOI
  10.1038/s41467-022-28056-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05414, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H05647, KAKENHI-PROJECT-19H00982, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20J20669, KAKENHI-PROJECT-20K05760, KAKENHI-PROJECT-20H03475
[Journal Article] Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble2022
- Author(s)
  Dixon Austin D.、Inoue Asuka、Robson Scott A.、Culhane Kelly J.、Trinidad Jonathan C.、Sivaramakrishnan Sivaraj、Bumbak Fabian、Ziarek Joshua J.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 23 Pages: 10241-10250
- DOI
  10.1021/jacs.2c00828
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] G protein-biased LPAR1 agonism promotes prototypic antidepressant effects2022
- Author(s)
  Kajitani Naoto、Okada-Tsuchioka Mami、Inoue Asuka、Miyano Kanako、Masuda Takeshi、Boku Shuken、Iwamoto Kazuya、Ohtsuki Sumio、Uezono Yasuhito、Aoki Junken、Takebayashi Minoru
- Journal Title
  
  bioRxiv
  
  Volume: - Pages: 514841-514841
- DOI
  10.1101/2022.11.02.514841
- Open Access
- Data Source
  KAKENHI-PROJECT-21K07501, KAKENHI-PROJECT-18H02756
[Journal Article] Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol2022
- Author(s)
  Nureki Ikko、Kobayashi Kazuhiro、Tanaka Tatsuki、Demura Kanae、Inoue Asuka、Shihoya Wataru、Nureki Osamu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 611 Pages: 158-164
- DOI
  10.1016/j.bbrc.2022.04.065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-21H05037, KAKENHI-PROJECT-23K24014, KAKENHI-PLANNED-19H05777
[Journal Article] Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex2022
- Author(s)
  Chen Geng、Xu Jun、Inoue Asuka、Schmidt Maximilian F.、Bai Chen、Lu Qiuyuan、Gmeiner Peter、Liu Zheng、Du Yang
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2375-2375
- DOI
  10.1038/s41467-022-30081-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex2022
- Author(s)
  Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
- Journal Title
  
  Cell Rep.
  
  Volume: 40(11) Issue: 11 Pages: 111323-111323
- DOI
  10.1016/j.celrep.2022.111323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428, KAKENHI-PUBLICLY-22H04753, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-20H03434
[Journal Article] Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism2021
- Author(s)
  Xu Zhenmei、Ikuta Tatsuya、Kawakami Kouki、Kise Ryoji、Qian Yu、Xia Ruixue、Sun Ming-Xia、Zhang Anqi、Guo Changyou、Cai Xue-Hui、Huang Zhiwei、Inoue Asuka、He Yuanzheng
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 18 Issue: 3 Pages: 281-288
- DOI
  10.1038/s41589-021-00930-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791
[Journal Article] Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.2021
- Author(s)
  Nagiri, C., Kobayashi, K., Tomita, A., Kato, M., Kobayashi, K., Yamashita, K., Nishizawa, T., Inoue, A., Shihoya, W. and Nureki, O.
- Journal Title
  
  Mol. Cell
  
  Volume: 81 Issue: 15 Pages: 3205-3215
- DOI
  10.1016/j.molcel.2021.06.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PUBLICLY-20H05437, KAKENHI-PROJECT-20J13299, KAKENHI-PROJECT-20K15728, KAKENHI-PROJECT-21H05037
[Journal Article] Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)2021
- Author(s)
  Katayama Kota、Suzuki Kohei、Suno Ryoji、Kise Ryoji、Tsujimoto Hirokazu、Iwata So、Inoue Asuka、Kobayashi Takuya、Kandori Hideki
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1-10
- DOI
  10.1038/s42003-021-02836-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05440, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-21H04969, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-23K21097
[Journal Article] Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors2021
- Author(s)
  Pandey Shubhi、Kumari Punita、Baidya Mithu、Kise Ryoji、Cao Yubo、Dwivedi-Agnihotri Hemlata、Banerjee Ramanuj、Li Xaria X.、Cui Cedric S.、Lee John D.、Kawakami Kouki、Maharana Jagannath、Ranjan Ashutosh、Chaturvedi Madhu、Jhingan Gagan Deep、Laporte St?phane A.、Woodruff Trent M.、Inoue Asuka、Shukla Arun K.
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 22 Pages: 4605-4621.e11
- DOI
  10.1016/j.molcel.2021.09.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04791
[Journal Article] Cryo-EM structure of the human MT1-Gi signaling complex.2021
- Author(s)
  Okamoto, H. H., Miyauchi, H., Inoue, A., Raimondi, F., Tsujimoto, H., Kusakizako, T., Shihoya, W., Yamashita, K., Suno, R., Nomura, N., Kobayashi, T., Iwata, S., Nishizawa, T. and Nureki, O.
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 28 Issue: 8 Pages: 694-701
- DOI
  10.1038/s41594-021-00634-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06294, KAKENHI-PLANNED-21H05112, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-19H03428, KAKENHI-PROJECT-21K19360, KAKENHI-PROJECT-20K15754, KAKENHI-PROJECT-22KJ0604, KAKENHI-PROJECT-21H05037, KAKENHI-PLANNED-19H05777
[Journal Article] Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors2021
- Author(s)
  Seibel-Ehlert Ulla、Plank Nicole、Inoue Asuka、Bernhardt Guenther、Strasser Andrea
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 18 Pages: 9739-9739
- DOI
  10.3390/ijms22189739
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04791
[Journal Article] Structure of the neurotensin receptor 1 in complex with β-arrestin 12020
- Author(s)
  Huang Weijiao、Masureel Matthieu、Qu Qianhui、Janetzko John、Inoue Asuka、Kato Hideaki E.、Robertson Michael J.、Nguyen Khanh C.、Glenn Jeffrey S.、Skiniotis Georgios、Kobilka Brian K.
- Journal Title
  
  Nature
  
  Volume: 579 Issue: 7798 Pages: 303-308
- DOI
  10.1038/s41586-020-1953-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-19H03163
[Journal Article] The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone2020
- Author(s)
  Asada Hidetsugu、Inoue Asuka、Ngako Kadji Francois Marie、Hirata Kunio、Shiimura Yuki、Im Dohyun、Shimamura Tatsuro、Nomura Norimichi、Iwanari Hiroko、Hamakubo Takao、Kusano-Arai Osamu、Hisano Hiromi、Uemura Tomoko、Suno Chiyo、Aoki Junken、Iwata So
- Journal Title
  
  Structure
  
  Volume: 28 Issue: 4 Pages: 418-425.e4
- DOI
  10.1016/j.str.2019.12.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05334, KAKENHI-PROJECT-18K16217, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-17K19349, KAKENHI-PROJECT-20K21392, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-18H02388
[Journal Article] Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein2020
- Author(s)
  Kobayashi Kazuhiro、Shihoya Wataru、Nishizawa Tomohiro、Kadji Francois Marie Ngako、Aoki Junken、Inoue Asuka、Nureki Osamu
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 27 Issue: 3 Pages: 274-280
- DOI
  10.1038/s41594-020-0386-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05000, KAKENHI-PROJECT-17J30010, KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-18K14634, KAKENHI-PROJECT-20J21820
[Journal Article] Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach2020
- Author(s)
  Sayama Misa、Uwamizu Akiharu、Otani Yuko、Inoue Asuka、Aoki Junken、Sekijima Masakazu、Ohwada Tomohiko
- Journal Title
  
  Biochemistry
  
  Volume: 59 Issue: 11 Pages: 1173-1201
- DOI
  10.1021/acs.biochem.0c00061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-19H03366
[Journal Article] Activation of the GLP-1 receptor by a non-peptidic agonist2020
- Author(s)
  Zhao Peishen、Liang Yi-Lynn、Belousoff Matthew J.、Deganutti Giuseppe、Fletcher Madeleine M.、Willard Francis S.、Bell Michael G.、Christe Michael E.、Sloop Kyle W.、Inoue Asuka、Truong Tin T.、Clydesdale Lachlan、Furness Sebastian G. B.、Christopoulos Arthur、Wang Ming-Wei、et al
- Journal Title
  
  Nature
  
  Volume: 577 Issue: 7790 Pages: 432-436
- DOI
  10.1038/s41586-019-1902-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-19K21176
[Journal Article] Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy2019
- Author(s)
  Wu Victoria、Yeerna Huwate、Nohata Nijiro、Chiou Joshua、Harismendy Olivier、Raimondi Francesco、Inoue Asuka、Russell Robert B.、Tamayo Pablo、Gutkind J. Silvio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 29 Pages: 11062-11086
- DOI
  10.1074/jbc.rev119.005601
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL25002019
- Author(s)
  Nagiri Chisae、Shihoya Wataru、Inoue Asuka、Kadji Francois Marie Ngako、Aoki Junken、Nureki Osamu
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 1-11
- DOI
  10.1038/s42003-019-0482-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J30010, KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-18K14634, KAKENHI-PROJECT-16H06294
[Journal Article] Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine2019
- Author(s)
  Kimura Kanako Terakado、Asada Hidetsugu、Inoue Asuka、Kadji Francois Marie Ngako、Im Dohyun、Mori Chihiro、Arakawa Takatoshi、Hirata Kunio、Nomura Yayoi、Nomura Norimichi、Aoki Junken、Iwata So、Shimamura Tatsuro
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 26 Issue: 2 Pages: 121-128
- DOI
  10.1038/s41594-018-0180-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-18K05334, KAKENHI-PROJECT-17K19349, KAKENHI-PROJECT-18H02388, KAKENHI-PROJECT-19H00923, KAKENHI-PLANNED-19H05777
[Journal Article] Illuminating G-Protein-Coupling Selectivity of GPCRs2019
- Author(s)
  Inoue Asuka、Raimondi Francesco、Kadji Francois Marie Ngako、Singh Gurdeep、Kishi Takayuki、Uwamizu Akiharu、Ono Yuki、Shinjo Yuji、Ishida Satoru、Arang Nadia、Kawakami Kouki、Gutkind J. Silvio、Aoki Junken、Russell Robert B.
- Journal Title
  
  Cell
  
  Volume: 177 Issue: 7 Pages: 1933-1947.e25
- DOI
  10.1016/j.cell.2019.04.044
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Conformational transitions of a neurotensin receptor?1?Gi1?complex2019
- Author(s)
  Kato Hideaki E.、Zhang Yan、Hu Hongli、Suomivuori Carl-Mikael、Kadji Francois Marie Ngako、Aoki Junken、Krishna Kumar Kaavya、Fonseca Rasmus、Hilger Daniel、Huang Weijiao、Latorraca Naomi R.、Inoue Asuka、Dror Ron O.、Kobilka Brian K.、Skiniotis Georgios
- Journal Title
  
  Nature
  
  Volume: 572 Issue: 7767 Pages: 80-85
- DOI
  10.1038/s41586-019-1337-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03163, KAKENHI-PROJECT-17K08264
[Journal Article] PRECOG: PREdicting COupling probabilities of G-protein coupled receptors2019
- Author(s)
  Singh Gurdeep、Inoue Asuka、Gutkind J Silvio、Russell Robert B、Raimondi Francesco
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Issue: W1 Pages: W395-W401
- DOI
  10.1093/nar/gkz392
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation2019
- Author(s)
  Mackenzie Amanda E.、Quon Tezz、Lin Li-Chiung、Hauser Alexander S.、Jenkins Laura、Inoue Asuka、Tobin Andrew B.、Gloriam David E.、Hudson Brian D.、Milligan Graeme
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 4 Pages: 5005-5017
- DOI
  10.1096/fj.201801956r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins2019
- Author(s)
  Bowin Carl-Fredrik、Inoue Asuka、Schulte Gunnar
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 31 Pages: 11677-11684
- DOI
  10.1074/jbc.ac119.009412
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis2019
- Author(s)
  Hoare Bradley L.、Bruell Shoni、Sethi Ashish、Gooley Paul R.、Lew Michael J.、Hossain Mohammed A.、Inoue Asuka、Scott Daniel J.、Bathgate Ross A.D.
- Journal Title
  
  iScience
  
  Volume: 11 Pages: 93-113
- DOI
  10.1016/j.isci.2018.12.004
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm2019
- Author(s)
  Raimondi Francesco、Inoue Asuka、Kadji Francois M. N.、Shuai Ni、Gonzalez Juan-Carlos、Singh Gurdeep、de la Vega Alicia Alonso、Sotillo Rocio、Fischer Bernd、Aoki Junken、Gutkind J. Silvio、Russell Robert B.
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 38 Pages: 6491-6506
- DOI
  10.1038/s41388-019-0895-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Variable G protein determinants of GPCR coupling selectivity2019
- Author(s)
  Okashah Najeah、Wan Qingwen、Ghosh Soumadwip、Sandhu Manbir、Inoue Asuka、Vaidehi Nagarajan、Lambert Nevin A.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 116 Issue: 24 Pages: 12054-12059
- DOI
  10.1073/pnas.1905993116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes2019
- Author(s)
  Hisano Yu、Kono Mari、Cartier Andreane、Engelbrecht Eric、Kano Kuniyuki、Kawakami Kouki、Xiong Yanbao、Piao Wenji、Galvani Sylvain、Yanagida Keisuke、Kuo Andrew、Ono Yuki、Ishida Satoru、Aoki Junken、Proia Richard L.、Bromberg Jonathan S.、Inoue Asuka、Hla Timothy
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 216 Issue: 7 Pages: 1582-1598
- DOI
  10.1084/jem.20181895
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Targeting GLP-1 receptor trafficking to improve agonist efficacy2018
- Author(s)
  Jones Ben、Buenaventura Teresa、Kanda Nisha、Chabosseau Pauline、Owen Bryn M.、Scott Rebecca、Goldin Robert、Angkathunyakul Napat、Corr?a Jr Ivan R.、Bosco Domenico、Johnson Paul R.、Piemonti Lorenzo、Marchetti Piero、Shapiro A. M. James、Cochran Blake J.、Hanyaloglu Aylin C.、Inoue Asuka、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-018-03941-2
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation2018
- Author(s)
  Shihoya Wataru、Izume Tamaki、Inoue Asuka、Yamashita Keitaro、Kadji Francois Marie Ngako、Hirata Kunio、Aoki Junken、Nishizawa Tomohiro、Nureki Osamu
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41467-018-07094-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08264, KAKENHI-PROJECT-18K14634, KAKENHI-PROJECT-17J30010, KAKENHI-PROJECT-16H06294, KAKENHI-PROJECT-17H05000
[Journal Article] Genome Editing Provides New Insights into Receptor Controlled Signalling Pathways.2018
- Author(s)
  Milligan G, Inoue A.
- Journal Title
  
  Trends Pharmacol Sci.
  
  Volume: in press Issue: 5 Pages: 481-493
- DOI
  10.1016/j.tips.2018.02.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Human GIP(3-30)NH 2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors2018
- Author(s)
  Gabe Maria Buur Nordskov、Sparre-Ulrich Alexander Hovard、Pedersen Mie Fabricius、Gasbjerg L?rke Smidt、Inoue Asuka、Br?uner-Osborne Hans、Hartmann Bolette、Rosenkilde Mette Marie
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 150 Pages: 97-107
- DOI
  10.1016/j.bcp.2018.01.040
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor2018
- Author(s)
  Valkovic Adam L.、Leckey Miranda B.、Whitehead Alice R.、Hossain Mohammed A.、Inoue Asuka、Kocan Martina、Bathgate Ross A. D.
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 6 Issue: 5
- DOI
  10.1002/prp2.432
- NAID
  120006873133
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] On the G protein-coupling selectivity of the native A2B adenosine receptor.2018
- Author(s)
  Gao ZG, Inoue A, Jacobson KA
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 39 Pages: 481-493
- DOI
  10.1016/j.bcp.2017.12.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes2018
- Author(s)
  O'Brien Shannon L.、Johnstone Elizabeth K.M.、Devost Dominic、Conroy Jacinta、Reichelt Melissa E.、Purdue Brooke W.、Ayoub Mohammed A.、Kawai Tatsuo、Inoue Asuka、Eguchi Satoru、H?bert Terence E.、Pfleger Kevin D.G.、Thomas Walter G.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 158 Pages: 232-242
- DOI
  10.1016/j.bcp.2018.10.017
- Data Source
  KAKENHI-PROJECT-17K08264
[Journal Article] Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo2014
- Author(s)
  Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A, Aoki J
- Journal Title
  
  J. Biochem
  
  Volume: 155 Issue: 4 Pages: 235
- DOI
  10.1093/jb/mvt114
- NAID
  40020035029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J05211, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-24770114, KAKENHI-PROJECT-24790064, KAKENHI-PROJECT-24890014, KAKENHI-PROJECT-25430135, KAKENHI-PROJECT-25860021, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26293012, KAKENHI-PROJECT-26640064
[Journal Article] A novel mutation, c.699C>G (p.C233W), in the LIPH gene leads to a loss of the hydrolytic activity and the LPA6 activation ability of PA-PLA1α in autosomal recessive wooly hair/hypotrichosis.2013
- Author(s)
  Yoshizawa M, Nakamura M, Farooq M, Inoue A, Aoki J, Shimomura Y.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 72 Issue: 1 Pages: 61-4
- DOI
  10.1016/j.jdermsci.2013.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790064
[Journal Article] 新規GPCR活性化検出法を利用したオーファン受容体のリガンドの同定2013
- Author(s)
  井上飛鳥
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 1029-33
- NAID
  40019893957
- Data Source
  KAKENHI-PROJECT-24790064
[Journal Article] Mitochondria-type GPAT is required for mitochondrial fusion2013
- Author(s)
  Yohsuke Ohba, Takeshi Sakuragi, Eriko Kage-Nakadai, Naoko H Tomioka, Nozomu Kono, Rieko Imae, Asuka Inoue, Junken Aoki, Naotada Ishihara, Takao Inoue, Shohei Mitani and Hiroyuki Arai
- Journal Title
  
  The EMBO Journal
  
  Volume: 32 Issue: 9 Pages: 1265
- DOI
  10.1038/emboj.2013.77
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J10377, KAKENHI-PROJECT-23227004, KAKENHI-PROJECT-23790256, KAKENHI-PROJECT-24390053, KAKENHI-PROJECT-24790064, KAKENHI-PROJECT-24790092, KAKENHI-PROJECT-25460060
[Journal Article] Prestwich GD. Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA) : metabolically stabilized LPA receptor agonists2013
- Author(s)
  Jiang G, Inoue A, Aoki J
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 6 Pages: 1865-9
- DOI
  10.1016/j.bmcl.2013.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790064, KAKENHI-ORGANIZER-22116001
[Journal Article] TGFα shedding assay: An accurate and versatile method for detecting GPCR activation2012
- Author(s)
  Asuka Inoue
- Journal Title
  
  Nat Methods
  
  Volume: 9 Issue: 10 Pages: 1021
- DOI
  10.1038/nmeth.2172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659025, KAKENHI-PROJECT-24659280, KAKENHI-PROJECT-24790064, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PUBLICLY-23112513
[Journal Article] Synthesis and biological evaluation of optically active Ki164252012
- Author(s)
  Sato, T. Sugimoto, K. Inoue, A. Okudaira, S. Aoki, J. Tokuyama, H.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 22 Issue: 13 Pages: 4323-4326
- DOI
  10.1016/j.bmcl.2012.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790064
[Journal Article] Crystal structure of autotaxin and insight into GPCR activation by lipid mediators2011
- Author(s)
  Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O.
- Journal Title
  
  Nat Struct Mol Biol.
  
  Volume: 18(2) Pages: 205-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790058
[Journal Article] Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLAlalpha in autosomal recessive hypotrichosis2010
- Author(s)
  Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H.
- Journal Title
  
  Hum Mutat.
  
  Volume: 31(5) Pages: 602-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790058
[Journal Article] 第二世代の生理活性脂質としてのリゾリン脂質2009
- Author(s)
  井上飛鳥、青木淳賢
- Journal Title
  
  実験医学
  
  Volume: 27(13) Pages: 2059-2067
- Data Source
  KAKENHI-PROJECT-21790058
[Journal Article] 第二世代の生理活性脂質としてのリゾリン脂質2009
- Author(s)
  井上飛鳥、青木淳賢
- Journal Title
  
  実験医学 27
  
  Pages: 2059-2067
- Data Source
  KAKENHI-PROJECT-21790058
[Patent] Gタンパク質共役型受容体のシグナル伝達の検出方法2014
- Inventor(s)
  青木淳賢、井上飛鳥
- Industrial Property Rights Holder
  青木淳賢、井上飛鳥
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24790064
[Patent] Gタンパク質共役型受容体のシグナル伝達の検出方法2014
- Inventor(s)
  青木淳賢、井上飛鳥
- Industrial Property Rights Holder
  青木淳賢、井上飛鳥
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24790064
[Patent] 自己免疫疾患治療薬2012
- Inventor(s)
  青木淳賢、巻出久美子、井上飛鳥、大和田智彦他
- Industrial Property Rights Holder
  青木淳賢、巻出久美子、井上飛鳥、大和田智彦他
- Industrial Property Rights Type
  特許
- Filing Date
  2012-05-18
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] レポーターアッセイを用いたGPCRシグナルネットワークの解明2023
- Author(s)
  齋藤郁貴、木瀬亮次、川上耕季、井上飛鳥
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] GPCRとβアレスチンの結合多様性と機能的役割の解析2023
- Author(s)
  中村楽、桑原莉来、川上耕季、井上飛鳥
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] Alternate activation mechanisms of β-arrestins and G proteins2023
- Author(s)
  Asuka Inoue
- Organizer
  Structure, Function and Dynamics International Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] ケモジェネティクスを用いたG12シグナルの脂肪肝抑制効果とその機構解析2023
- Author(s)
  荒井魁斗、小野雄基、井上飛鳥
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] Non-canonical activation of β-arrestin and G protein2023
- Author(s)
  Asuka Inoue
- Organizer
  GPCR Workshop 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] GPCR におけるバイアスシグナル創出基点とその機構の解析2023
- Author(s)
  中村楽、川上耕季、生田達也、井上飛鳥
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] Non-canonical activation of β-arrestin and G protein2023
- Author(s)
  Asuka Inoue
- Organizer
  GPCR Workshop 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] 化学遺伝学的手法を用いた脂肪肝におけるG12共役型GPCRの機能解析2023
- Author(s)
  荒井魁斗、小野雄基、井上飛鳥
- Organizer
  第22回次世代を担う若手のためのファーマ・バイオフォーラム2023
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] GPCRに対する結合様式によってβアレスチンは機能を区別する2023
- Author(s)
  桑原莉来、柳川正隆、中村楽、井上飛鳥
- Organizer
  第22回次世代を担う若手のためのファーマ・バイオフォーラム2023
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 日本人に特徴的なGPCR遺伝子バリアントの探索2022
- Author(s)
  鈴木璃子、生田達也、川上耕季、井上飛鳥
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 第三の結合様式におけるアレスチンの機能の解明2022
- Author(s)
  桑原莉来、川上耕季、倉本律輝、生田達也、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] オピオイド受容体のシグナル解読とバイアス型リガンドによる自在制御2022
- Author(s)
  井上飛鳥
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] オピオイド受容体のシグナル解読とバイアス型リガンドによる自在制御2022
- Author(s)
  井上飛鳥
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] デザイナーGPCRを用いたG12シグナルの表皮における機能解析2022
- Author(s)
  平井夏実、古川史歩、小野雄基、井上飛鳥
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] GRK-independent arrestin activation2022
- Author(s)
  Asuka Inoue
- Organizer
  FASEB SRC: The G Protein-coupled Receptor Kinases and Arrestins Conference: Key Modulators of Signal Transduction
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] GRK-independent arrestin activation2022
- Author(s)
  Asuka Inoue
- Organizer
  FASEB SRC: The G Protein-coupled Receptor Kinases and Arrestins Conference: Key Modulators of Signal Transduction
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] Gαタンパク質を起点としたGRK-βアレスチン機能制御機構2022
- Author(s)
  川上耕季、柳川正隆、平塚寿々音、佐甲靖志、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 固有振動解析によるGPCRの多様なリガンドポケットの生成2022
- Author(s)
  生田達也、井上飛鳥
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 細分化して見えてくるGPCRシグナル原理2022
- Author(s)
  井上飛鳥
- Organizer
  第17回 GPCR研究会
- Invited
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 固有振動解析によって生成したGPCRコンフォメーションの評価2022
- Author(s)
  生田達也、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PLANNED-21H05113
[Presentation] 細分化して見えてくるGPCRシグナル原理第17回 GPCR研究会2022
- Author(s)
  井上飛鳥
- Organizer
  第17回 GPCR研究会
- Invited
- Data Source
  KAKENHI-ORGANIZER-21H05111
[Presentation] G12共役型DREADDを用いたG12シグナルの脂肪肝抑制作用の評価とその機構解析2022
- Author(s)
  荒井魁斗、小野雄基、井上飛鳥
- Organizer
  第17回 GPCR研究会
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] 結合様式の違いによる beta アレスチンの機能的、構造的差異2022
- Author(s)
  桑原莉来、川上耕季、井上飛鳥
- Organizer
  日本生化学会東北支部第88回例会
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] Biased ligands and GRK-subtype selectivity: negative regulations of GRK5/6 by Gq and its consequence for β-arrestin functionality2021
- Author(s)
  Asuka Inoue
- Organizer
  TARGET 2035-Chemical Probes for GPCRs
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] Back and forth between purified and cellular systems for GPCR biology2021
- Author(s)
  井上飛鳥
- Organizer
  第59回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] 酸化ストレス代謝物の標的膜受容体とその活性化検出2021
- Author(s)
  井上飛鳥
- Organizer
  第74回日本酸化ストレス学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] GPCR effector-KO HEK293 cell lines - how to dissect complexity of GPCR signaling2021
- Author(s)
  Asuka Inoue
- Organizer
  British Pharmacological Society Pharmacology 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04791
[Presentation] GPCR配列にコードされるGタンパク質シグナル選択性の解明2019
- Author(s)
  井上飛鳥
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] Abnormality in metabolism of docosahexaenoic acid-lysophosphatidic acid(DHA-LPA) in major depressive disorder and schizophrenia2019
- Author(s)
  Omori W，Kano K，Hattori K，Kajitani N，Itagaki K，Okada-Tsuchioka M，Abe H，Machino A，Inoue A，Kunugi H，Aoki J，Takebayashi M．
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02756
[Presentation] Decoding G-protein Coupling Selectivity with a Large Functional Dataset2019
- Author(s)
  Asuka Inoue
- Organizer
  GPCR Workshop 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] スプリットルシフェラーゼを用いた三量体Gタンパク質活性化の検出法の確立とGPCR研究への応用2018
- Author(s)
  井上飛鳥、Francois Marie Ngako Kadji、青木淳賢
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] A crystal structure of the lysophospholipid receptor LPA6and insights into lipid ligand entry and a hereditary hair disease2018
- Author(s)
  Asuka Inoue
- Organizer
  International GPCR Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] 三量体Gタンパク質の活性化センサーの開発2017
- Author(s)
  井上飛鳥、Francois Marie Marie Kadji、川上耕季、青木淳賢
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] NanoBiT-based G protein sensors2017
- Author(s)
  Asuka Inoue, FMN Kadji, Junken Aoki
- Organizer
  GPCR Workshop 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08264
[Presentation] LPA6の欠損は精原細胞の減少を引き起こす2016
- Author(s)
  岸田真輝、可野邦行、井上飛鳥、青木淳賢
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26440043
[Presentation] GPCR解析ツールの開発とGPCRを標的とするアカデミア創薬2016
- Author(s)
  井上飛鳥、青木淳賢
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PUBLICLY-16H01377
[Presentation] LPA6 欠損マウスにおける精巣の形成不全の解析2015
- Author(s)
  岸田真輝、可野邦行、井上飛鳥、青木淳賢
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26440043
[Presentation] Development of a versatile method to quantify coupling of all the four heterotrimeric G proteins2014
- Author(s)
  Asuka Inoue and Junken Aoki
- Organizer
  Keystone Symposia Z1: G Protein-Coupled Receptors: Structural Dynamics and Functional Implications (2014), USA
- Place of Presentation
  Snowbird Resort, Snowbird, Utah, USA
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] Dissecting G protein coupling of GPCRs using chimeric Gαsubunits and TGFαshedding assay2013
- Author(s)
  Inoue A, Aoki J
- Organizer
  International Conference on Pharmacology and Drug Development (ICoPaDD)
- Place of Presentation
  University of Singapore, Singapore
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] A tool to comprehensively dissect G protein coupling of GPCRs: application of TGFα shedding assay and co-expression of chimeric Gα subunits2013
- Author(s)
  Asuka Inoue and Junken Aoki
- Organizer
  Gordon Research Conferences, Molecular Pharmacology
- Place of Presentation
  Renaissance Tuscany Il Ciocco Resort, Lucca (Barga), Italy
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] TGFα切断を用いたGPCRと三量体Gタンパク質の共役活性の評価系の確立2013
- Author(s)
  井上飛鳥、青木淳賢
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] 酸化リン脂質を認識するGタンパク質共役型受容体2013
- Author(s)
  井上飛鳥、石黒純、青木淳賢
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  松島、宮城
- Invited
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] TGFα切断を用いたGPCRと三量体Gタンパク質の共役活性の評価系の確立2013
- Author(s)
  井上飛鳥、青木淳賢
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] A tool to comprehensively dissect G protein coupling of GPCRs : application of TGFαshedding assay and co-expression of chimeric Gαsubunits2013
- Author(s)
  Inoue A, Aoki J
- Organizer
  Gordon Research Conferences, Molecular Pharmacology. Renaissance Tuscany Il Ciocco Resort
- Place of Presentation
  Lucca (Barga), Italy.
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] A new tool to analyze G protein coupling of lipid mediator receptors2013
- Author(s)
  Asuka Inoue and Junken Aoki
- Organizer
  FASEB Summer Research Conferences, Lysophospholipid and other Related Mediators - From Bench to Clinic
- Place of Presentation
  ニセコ、北海道
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] Identification and analysis of GPCRs that recognize oxidized phospholipids2013
- Author(s)
  Inoue A, Ishiguro J, Aoki J
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜、神奈川
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] Dissecting G protein coupling of GPCRs using chimeric Gα subunits and TGFα shedding assay2013
- Author(s)
  Asuka Inoue and Junken Aoki
- Organizer
  International Conference on Pharmacology and Drug Development (ICoPaDD) Singapore
- Place of Presentation
  University of Singapore, Singapore
- Invited
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] TGFαのエクトドメイン切断を利用した新規GPCRリガンド探索のアッセイ系2013
- Author(s)
  井上飛鳥、青木淳賢
- Organizer
  第10回GPCR研究会
- Place of Presentation
  お台場、東京
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] A new tool to analyze G protein coupling of lipid mediator receptors2013
- Author(s)
  Inoue A, Aoki J
- Organizer
  FASEB Summer Research Conferences, Lysophospholipid and other Related Mediators - From Bench to Clinic
- Place of Presentation
  Niseko, Hokkaido, Japan.
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] TGFα切断を用いた脂質メディエーター受容体の検出法の開発2012
- Author(s)
  井上飛鳥、石黒純、巻出久美子、青木淳賢
- Organizer
  第54回日本脂質生化学
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] Development of a versatile GPCR assay and its application for ligand identification of orphan GPCRs2012
- Author(s)
  Asuka Inoue, Jun Ishiguro, Kumiko Makide and Junken Aoki
- Organizer
  LIPID MAPS Annual Meeting 2012
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] 毛髪形成メカニズムから派生したGタンパク質共役型受容体(GPCR)の新規検出系の開発とその応用2012
- Author(s)
  井上飛鳥、石黒純、巻出久美子、青木淳賢
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡、福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] 毛髪形成メカニズムから派生したGタンパク質共役型受容体（GPCR）の新規検出系の開発とその応用2012
- Author(s)
  井上飛鳥、石黒純、巻出久美子、青木淳賢
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] TGFα切断を用いた脂質メディエーター受容体の検出法の開発2012
- Author(s)
  井上飛鳥、石黒純、巻出久美子、青木淳賢
- Organizer
  第54回日本脂質生化学
- Place of Presentation
  福岡、九州大学
- Data Source
  KAKENHI-PROJECT-24790064
[Presentation] LC-ESI-MS/MSを用いた生理活性リゾリン脂質定量系の開発2011
- Author(s)
  井上飛鳥
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡、静岡県コンベンションアーツセンター
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LC-ESI-MS/MSを用いた生理活性リゾリン脂質定量系の開発2011
- Author(s)
  井上飛鳥
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LC-ESI-MS/MSを用いたリゾリン脂質定量系の開発2010
- Author(s)
  井上飛鳥
- Organizer
  第52回日本脂質生化学会
- Place of Presentation
  群馬、秋森旅館
- Year and Date
  2010-06-15
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGF-alpha release and EGFR transactivation2010
- Author(s)
  井上飛鳥
- Organizer
  The 27th Naito Conference on Menmbrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo, CHATERAISE Gateaux Kingdom SAPPORO
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LC-ESI-MS/MSを用いたリゾリン脂質定量系の開発2010
- Author(s)
  井上飛鳥
- Organizer
  第52回日本脂質生化学会
- Place of Presentation
  群馬
- Year and Date
  2010-06-15
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Cleavage of membrane-bound TGFa as a useful readout for GPCR activation2010
- Author(s)
  Asuka Inoue
- Organizer
  Satellite Symposium of the 14th International Congress of Endocrinology (ICE2010)
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LC-ESI-MS/MSを用いたリゾリン脂質定量系の開発2010
- Author(s)
  井上飛鳥
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGF-alpha release and EGFR transactivation2010
- Author(s)
  Asuka Inoue
- Organizer
  he 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Cleavage of membrane-bound TGFa as a useful readout for GPCR activation2010
- Author(s)
  Asuka Inoue, Jun Ishiguro, Naoaki Arima, Shigeki Higashiyama, Junken Aoki
- Organizer
  Satellite Symposium of the 14th International Congress of Endocrinology(ICE2010)
- Place of Presentation
  京都
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGFa release and EGFR transactivation2010
- Author(s)
  Asuka Inoue
- Organizer
  Keystone Symposia Bioactive Lipids: Biochemistry and Diseases (D2)
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGFa release and EGFR transactivation2010
- Author(s)
  井上飛鳥
- Organizer
  Keystone Symposia Bioactive Lipids : Biochemistry and Diseases (D2)
- Place of Presentation
  Kyoto, Westin Miyako Kyoto
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGFa cleavage2009
- Author(s)
  Asuka Inoue
- Organizer
  FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
- Place of Presentation
  Arizona, USA
- Year and Date
  2009-06-30
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid is involved in hair follicle formation2009
- Author(s)
  Asuka Inoue
- Organizer
  he 5th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] EGF受容体リガンド切断アッセイを用いた新規リゾホスファチジン酸受容体P2Y5の機能解析2009
- Author(s)
  井上飛鳥
- Organizer
  第6回GPCR研究会
- Place of Presentation
  東京
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LYSOPHOSPHATIDIC ACID PLAYS A CRITICAL ROLE IN HAIR FOLLICLE FORMATION THROUGH TGF-ALPHA SHEDDING2009
- Author(s)
  Asuka Inoue, Naoaki Arima, Hiroyuki Arai, Junken Aoki
- Organizer
  4th International Conference on Phospholipase A2 and Lipid Mediators(PLM2009)
- Place of Presentation
  東京
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid is involved in hair follicle formation2009
- Author(s)
  Asuka Inoue, Naoaki Arima, Hiroyuki Arai, Junken Aoki
- Organizer
  The 5th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  東京
- Year and Date
  2009-05-25
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] 広範囲のGPCRシグナル検出を目的としたGαタンパク質共発現によるTGFα切断アッセイ系の確立2009
- Author(s)
  井上飛鳥
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical roles in hair follicle formation via EGFR transactivation2009
- Author(s)
  井上飛鳥、有馬直明、新井洋由、青木淳賢
- Organizer
  第十回文部科学省特定領域研究「がん」5領域若手研究者ワークショップ
- Place of Presentation
  蓼科
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] Lysophosphatidic acid plays a critical role in hair follicle formation through TGFa cleavage2009
- Author(s)
  Asuka Inoue, Naoaki Arima, Hiroyuki Arai, Junken Aoki
- Organizer
  FASEB Summer Research Conference "Lysophospholipid Mediators in Health and Disease"
- Place of Presentation
  アメリカ合衆国、アリゾナ州ケアフリー
- Year and Date
  2009-06-30
- Data Source
  KAKENHI-PROJECT-21790058
[Presentation] LYSOPHOSPHATIDIC ACID PLAYS A CRITICAL ROLE IN HAIR FOLLICLE FORMATION THROUGH TGF-ALPHA SHEDDING2009
- Author(s)
  Asuka Inoue
- Organizer
  4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009)
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-21790058

1. Takebayashi Minoru (60304440)

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# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 沓村憲樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 宮野加奈子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 上園保仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. くぬ刀浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 朴三用

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 今村香代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 廣島通夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 酒井寿郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 梶谷直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 柳沢正史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 小川亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 内田浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 小林拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 井上明俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE ASUKA 井上 飛鳥

INOUE Asuka 井上 飛鳥

Research Projects

Research Products

Co-Researchers

G13共役型デザイナーGPCRの開発と遺伝薬理学論の概念実証Principal Investigator

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受容体分解の制御機構解明から開拓する分解誘導薬の合理的設計論Principal Investigator

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ミトラガイナアルカロイドを基盤とする副作用を示さないオピオイド作動性鎮痛薬の創製

Principal Investigator

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Multi-scale platform for untangling physiological complexity

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Identification of pharmacologically relevant signaling pathways at opioid receptorsPrincipal Investigator

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Manipulation of G12/13 signaling and and drug development strategyPrincipal Investigator

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Structural dynamics of GPCR in cells

Principal Investigator

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A study of novel lysophospholipids and exploration of their targets

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Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)

Principal Investigator

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Signaling basis of GPCR-acting drugs and their therapeutic mechanismsPrincipal Investigator

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Understanding lipid-regulated TRP channels and their roles in thermal biologyPrincipal Investigator

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A role of lysophosphatidic acid signaling in male organPrincipal Investigator

Principal Investigator

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Screening for ligands of G protein-coupled receptors using the newly developed TGFalpha shedding assayPrincipal Investigator

Principal Investigator

Project Period (FY)

INOUE ASUKA 井上飛鳥

INOUE Asuka 井上飛鳥