Suzuki Toshihiro 鈴木利宙

Researcher Number	50530135
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2021 – 2023: 帝京大学, 医学部, 助教 2020: 帝京大学, 公私立大学の部局等, 助教 2019: 帝京大学, 公私立大学の部局等, 講師 2018: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 49020:Human pathology-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 腫瘍応答性T細胞 / 個別化がん免疫療法 / 腫瘍内免疫環境 / ネオアンチゲン予測パイプライン / TCR遺伝子決定 / 自己腫瘍反応性の評価 / 肝胆膵領域がん / TCR導入T細胞療法 / 遺伝子治療 / 遺伝子マーカー … More / トランスクリプトーム解析 / TCR再構築 / グリピカン3 / TCR遺伝子 / 腫瘍内浸潤T細胞 / 共通がん抗原 / TCR遺伝子導入T細胞 / 非ウイルス性肝細胞がん / 自己腫瘍反応性 / ネオアンチゲン / がん抗原 / TCR導入T細胞 / 疲弊化機構 / シングル細胞解析 / 腫瘍浸潤T細胞 … More Except Principal Investigator 紡錘形細胞がん / 未分化がん / 肉腫様がん / Cas9 / polymeric micelles / Endosome escape / Cathepsin B / KRAS / Cancer / Gene editing / チロシンリン酸化シグナル / オルガネラ / 細胞内分子イメージング / 細胞内輸送阻害剤 / 分子標的薬 / FLT3-ITD / 変異型チロシンキナーゼ / FLT3 / 細胞内局在 / FLT3変異 / 急性骨髄性白血病 Less

ヒト肝がんにおけるがん反応性組織常在メモリーT細胞の腫瘍内活性化制御機構の解明Principal Investigator
- Principal Investigator
  
  鈴木利宙
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
Construction of the sarcomatoid carcinoma concept and pathological investigation
- Principal Investigator
  
  小嶋基寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
Development of Innovative Cancer Genome Editing Therapy Using Polymeric Micelles Implementing High Precision Intracellular Delivery Function
- Principal Investigator
  
  Cabral Horacio
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Understanding the organelle signaling of mutant FLT3 in Acute Myeloid Leukemia (AML) to develop novel therapeutic tactics
- Principal Investigator
  
  Abe Ryo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Teikyo University
Identification and application of tumor reactive T cells in hepatobiliary and pancreatic cancers to personalized cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Suzuki Toshihiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Teikyo University
  National Cancer Center Japan

All 2022 2021 2020 2019 2018 Other

All Journal Article Presentation Other

[Journal Article] Component with abundant immune‐related cells in combined hepatocellular cholangiocarcinoma identified by cluster analysis2022
- Author(s)
  Yagi Naoki、Suzuki Toshihiro、Mizuno Shoichi、Kojima Motohiro、Kudo Masashi、Sugimoto Motokazu、Kobayashi Shin、Gotohda Naoto、Ishii Genichiro、Nakatsura Tetsuya
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 5 Pages: 1564-1574
- DOI
  10.1111/cas.15313
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] ネオアンチゲンとがん免疫2022
- Author(s)
  鈴木　利宙、藤浪　紀洋、下村　真菜美、Charneau Jimmy、平糠　和志、山田　崇、三嶋　雄二、渡部　典子、中村徳弘、中面　哲也
- Journal Title
  
  腫瘍内科
  
  Volume: 29(2) Pages: 213-219
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Development of antigen‐prediction algorithm for personalized neoantigen vaccine using human leukocyte antigen transgenic mouse2022
- Author(s)
  Charneau Jimmy、Suzuki Toshihiro、Shimomura Manami、Fujinami Norihiro、Mishima Yuji、Hiranuka Kazushi、Watanabe Noriko、Yamada Takashi、Nakamura Norihiro、Nakatsura Tetsuya
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1113-1124
- DOI
  10.1111/cas.15291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma: Clinicopathologic, transcriptomic and immunologic analyses2021
- Author(s)
  Morisue Ryo、Kojima Motohiro、Suzuki Toshihiro、Nakatsura Tetsuya、Ojima Hidenori、Watanabe Reiko、Sugimoto Motokazu、Kobayashi Shin、Takahashi Shinichiro、Konishi Masaru、Ishii Genichiro、Gotohda Naoto、Fujiwara Toshiyoshi、Ochiai Atsushi
- Journal Title
  
  International Journal of Cancer
  
  Volume: - Issue: 3 Pages: 546-560
- DOI
  10.1002/ijc.33545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer.2021
- Author(s)
  Oka M, Xu L, Suzuki T, Yoshikawa T, Sakamoto H, Uemura H, Yoshizawa AC, Suzuki Y, Nakatsura T, Ishihama Y, Suzuki A, Seki M
- Journal Title
  
  Genome Biol.
  
  Volume: 22(1):9 Issue: 1 Pages: 1-9
- DOI
  10.1186/s13059-020-02240-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09297, KAKENHI-PLANNED-17H06306, KAKENHI-PROJECT-19K16108, KAKENHI-PROJECT-19K16792, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K08637, KAKENHI-ORGANIZER-17H06299
[Journal Article] FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells2021
- Author(s)
  Yamawaki Kouhei、Shiina Isamu、Murata Takatsugu、Tateyama Satoru、Maekawa Yutarou、Niwa Mariko、Shimonaka Motoyuki、Okamoto Koji、Suzuki Toshihiro、Nishida Toshirou、Abe Ryo、Obata Yuuki
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2021.01.01.424454
- Open Access
- Data Source
  KAKENHI-PROJECT-20K08719, KAKENHI-PROJECT-18K07208
[Journal Article] Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances2021
- Author(s)
  Charneau Jimmy、Suzuki Toshihiro、Shimomura Manami、Fujinami Norihiro、Nakatsura Tetsuya
- Journal Title
  
  Journal of Hepatocellular Carcinoma
  
  Volume: Volume 8 Pages: 1035-1054
- DOI
  10.2147/jhc.s291558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma2019
- Author(s)
  Akazawa Y, Suzuki T,　Yoshikawa T, Mizuno S, Nakamoto Y, and Nakatsura T
- Journal Title
  
  World J Metaanal.
  
  Volume: 7 Issue: 3 Pages: 80-95
- DOI
  10.13105/wjma.v7.i3.80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification.2018
- Author(s)
  Takahashi D, Kojima M, Suzuki T, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Gotohda N, Ikeda M, Nakatsura T, Ochiai A, Nagino M.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 13166-13166
- DOI
  10.1038/s41598-018-31383-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07035, KAKENHI-PROJECT-18K08637
[Journal Article] Infiltration into the Cancer Tissues2018
- Author(s)
  Akazawa Y, Suzuki T, Nakatsura T
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 45 Pages: 227-231
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] がん免疫療法の歴史と今後の課題2018
- Author(s)
  清水康弘、鈴木利宙、遠藤格、中面哲也
- Journal Title
  
  最新医学
  
  Volume: 73 Pages: 174-181
- Data Source
  KAKENHI-PROJECT-18K08637
[Journal Article] Cancer Immunotherapy Targeted Glypican-3 or Neoantigens.2018
- Author(s)
  Shimizu Y, Suzuki T, Yoshikawa T, Tsuchiya N, Sawada Y, Endo I, Nakatsura T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 109(3) Issue: 3 Pages: 531-541
- DOI
  10.1111/cas.13485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19990, KAKENHI-PROJECT-18K08637
[Presentation] Simultaneous analysis of TCR repertoire and transcriptome of tumor infiltrating T cells in hepatocellular carcinoma (HCC) by single-cell sequences identified clusters including tumor reactive CTLs with early effector like phenotype2021
- Author(s)
  鈴木利宙
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K08637
[Presentation] 個別化ペプチドワクチンの開発を目的としたネオアンチゲン予測とヒトHLA発現マウスによる予測ペプチドの抗原性の評価2021
- Author(s)
  鈴木利宙、下村　真菜美、藤浪　紀洋、吉川　聡明、平糠　和志、山田　崇、渡部　典子、三嶋　雄二、中村　徳弘、中面　哲也
- Organizer
  第18回日本免疫治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08637
[Presentation] Development of a novel personalized immunotherapy targeting common cancer antigen, glypican-3 (GPC3).2021
- Author(s)
  Charneau Jimmy, Suzuki Toshihiro, Kojima Motohiro, Gothoda Naoto, Takahashi Shinichiro, Sugimoto Motokazu, Suzuki Yutaka, Seki Masahide, Shimomura Manami, Kanaseki Takayuki, Nakatsura Tetsuya
- Organizer
  第18回日本免疫治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08637
[Presentation] Analysis of tumor-reactive CTLs and its application to personalized immunotherapy in Hepatobiliary and pancreatic carcinoma2020
- Author(s)
  Suzuki T, Aazawa Y, Shimizu Y, Yoshikawa T, Kojima M, Gotohda N, Takahashi S, Sugimoto M, Suzuki Y, Seki M, NakatsuraT
- Organizer
  日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-18K08637
[Presentation] The investigation of personalized immunotherapy targeting neoantigen for Liver, Pancreas, and Biliary tract cancer2018
- Author(s)
  鈴木利宙、赤澤悠、清水康博、吉川聡明、小嶋基寛、杉本元一、高橋進一郎、後藤田直人、関真秀、鈴木穣、中面哲也
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18K08637
[]

1. 小嶋基寛 (30338470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Abe Ryo (20159453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 中面哲也 (30343354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. 小幡裕希 (20609408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Cabral Horacio (10533911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 佐藤守俊 (00323501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 持田祐希 (60739134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高阪真路 (00627119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 吉川聡明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Suzuki Toshihiro 鈴木 利宙

Research Projects

Research Products

Co-Researchers

ヒト肝がんにおけるがん反応性組織常在メモリーT細胞の腫瘍内活性化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of the sarcomatoid carcinoma concept and pathological investigation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Innovative Cancer Genome Editing Therapy Using Polymeric Micelles Implementing High Precision Intracellular Delivery Function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the organelle signaling of mutant FLT3 in Acute Myeloid Leukemia (AML) to develop novel therapeutic tactics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and application of tumor reactive T cells in hepatobiliary and pancreatic cancers to personalized cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Component with abundant immune‐related cells in combined hepatocellular cholangiocarcinoma identified by cluster analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ネオアンチゲンとがん免疫2022

Author(s)

Journal Title

Data Source

[Journal Article] Development of antigen‐prediction algorithm for personalized neoantigen vaccine using human leukocyte antigen transgenic mouse2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma: Clinicopathologic, transcriptomic and immunologic analyses2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Infiltration into the Cancer Tissues2018

Author(s)

Suzuki Toshihiro 鈴木利宙