MIZUNO Keiko 水野圭子

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Mizuno Keiko 水野圭子

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Researcher Number	50531414
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 鹿児島大学病院, 特例准教授
Affiliation (based on the past Project Information) *help	2025: 鹿児島大学, 鹿児島大学病院, 特例准教授 2021 – 2024: 鹿児島大学, 医歯学総合研究科, 特任准教授 2020 – 2021: 鹿児島大学, 医歯学域鹿児島大学病院, 講師 2019 – 2020: 鹿児島大学, 医歯学総合研究科, 講師 2017 – 2020: 鹿児島大学, 医歯学総合研究科, 助教 2017: 鹿児島大学, 医歯学域医学系, 助教 2012 – 2014: 鹿児島大学, 医学部・歯学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 治療抵抗性 / 小細胞肺癌 / マイクロRNA / スーパーエンハンサー / 機能性RNA / ATACシークエンス / 転写因子 / 転写調節領域 / CRISPR-Cas9 / ドラッグリポジショニング … More / MCMファミリー / 炎症性サイトカイン / IL-13 / microRNA / miR-1/133a / 遺伝子 / マイクロアレイ / 肺癌 … More Except Principal Investigator 肺癌 / マイクロRNA / 分子細胞呼吸器学 / 肺扁平上皮癌 / microRNA / KRAS変異陽性非小細胞肺癌 / 間質性肺炎合併肺癌 / 間質性肺炎 / 扁平上皮癌 / 間質性合併肺癌 / 治療標的分子 / パッセンジャー鎖 / 肺線維症 / 核酸 / 特発性肺線維症 / 薬剤耐性 / 次世代シーケンサー / DONSON / 小細胞肺癌 / 治療抵抗性 Less

機能性RNA時間的階層性の理解に基づく、肺腺癌・KRAS阻害薬耐性機構の解明
- Principal Investigator
  
  武田亜矢
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kagoshima University
合成致死性に基づいたKRAS変異陽性肺癌におけるソトラシブ併用新規治療法の開発
- Principal Investigator
  
  萩原陽子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
肺癌細胞が血液脳関門を破錠し、脳転移を可能にする機能性RNAネットワークの解明
- Principal Investigator
  
  末次隆行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
オープンクロマチン領域を指標とした小細胞肺癌薬物耐性に関する分子機構の解明
- Principal Investigator
  
  眞田宏樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
治療抵抗性獲得に関与する小細胞肺癌機能性RNA分子アトラスの構築Principal Investigator
- Principal Investigator
  
  水野圭子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
Exploration Study of Molecular Pathways and Novel Therapies in Lung Squamous Cell Carcinoma Initiated by MicroRNAs
- Principal Investigator
  
  Uchida Akifumi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
Devising drug repositioning based on functional RNA integration analysis of small cell lung cancer.Principal Investigator
- Principal Investigator
  
  Mizuno Keiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
Exploration of molecular pathways for lung cancer with interstitial pneumonia and development of new treatments based on understanding of functional RNA integration
- Principal Investigator
  
  Sanada Hiroki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kagoshima University
Development of innovative therapy for treatment-resistant small cell lung cancer based on functional RNA network analysis
- Principal Investigator
  
  KUMAMOTO TOMOHIRO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kagoshima University
Investigation of the common RNA networks in lung cancer and idiopathic pulmonary fibrosis for the new strategy of the diseases.
- Principal Investigator
  
  MATAKI Hiroko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kagoshima University
Elucidation of the involvement of the inflammatory response and development of a new marker and treatment in lung cancer growthPrincipal Investigator
- Principal Investigator
  
  MIZUNO Keiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kagoshima University

All 2023 2021 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target2021
- Author(s)
  Misono Shunsuke、Mizuno Keiko、Suetsugu Takayuki、Tanigawa Kengo、Nohata Nijiro、Uchida Akifumi、Sanada Hiroki、Okada Reona、Moriya Shogo、Inoue Hiromasa、Seki Naohiko
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 6 Pages: 1187-1187
- DOI
  10.3390/cancers13061187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08627, KAKENHI-PROJECT-19K08656, KAKENHI-PROJECT-19K17640
[Journal Article] Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma2021
- Author(s)
  Mizuno Keiko、Tanigawa Kengo、Misono Shunsuke、Suetsugu Takayuki、Sanada Hiroki、Uchida Akifumi、Kawano Minami、Machida Kentaro、Asai Shunichi、Moriya Shogo、Inoue Hiromasa、Seki Naohiko
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 12 Pages: 1883-1883
- DOI
  10.3390/biomedicines9121883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08627, KAKENHI-PROJECT-19K08656, KAKENHI-PROJECT-21K09577
[Journal Article] The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes2017
- Author(s)
  Mizuno Keiko、Mataki Hiroko、Arai Takayuki、Okato Atsushi、Kamikawaji Kazuto、Kumamoto Tomohiro、Hiraki Tsubasa、Hatanaka Kazuhito、Inoue Hiromasa、Seki Naohiko
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 62 Issue: 7 Pages: 671-678
- DOI
  10.1038/jhg.2017.27
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19458
[Journal Article] Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.2016
- Author(s)
  Kamikawaji K, Seki N, Watanabe M, Mataki H, Kumamoto T, Takagi K, Mizuno K, Inoue H.
- Journal Title
  
  J Hum GenetJ Hum Genet.
  
  Volume: 12 Pages: 985-993
- NAID
  40021022822
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19458
[Journal Article] Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C2015
- Author(s)
  Mataki H, Enokida H, Chiyomaru T, Mizuno K, Matsushita R, Goto Y, Nishikawa R, Higashimoto I, Samukawa T, Nakagawa M, Inoue H, Seki N.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 60 Issue: 2 Pages: 53
- DOI
  10.1038/jhg.2014.111
- NAID
  40020367992
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-24659407, KAKENHI-PROJECT-25293192
[Journal Article] Tumor-suppressive microRNA-206 as a dual inhibitor of MET and EGFR oncogenic signaling in lung squamous cell carcinoma2015
- Author(s)
  Mataki H, Seki N, Chiyomaru T, Enokida H, Goto Y, Kumamoto T, Machida K, Mizuno K, Nakagawa M, Inoue H.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Issue: 3 Pages: 1039
- DOI
  10.3892/ijo.2014.2802
- URL
  https://localhost/en/publications/fe60bff1-81a5-4b4c-8b1a-78995f8c63b0
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592590, KAKENHI-PROJECT-24659407, KAKENHI-PROJECT-25293192
[Presentation] RNAシークエンスに基づくマイクロRNA発現プロファイルの作成：治療性抵抗性小細胞肺癌での解析2023
- Author(s)
  冨岡勇也、谷川健悟、美園俊祐、萩原陽子、末次隆行、水野圭子、井上博雅
- Organizer
  第63回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-22K08260
[Presentation] Minichromosome maintenance complex component (MCM) genes in lung adenocarcinoma: MCM-family acts as a potential therapeutic target2021
- Author(s)
  cKengo Tanigawa, Keiko Mizuno, Shunsuke Misono, Minami Kawano, Takayuki Suetsugu, Hiromasa Inoue
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08627
[Presentation] Minichromosome maintenance complex component (MCM) genes in lung adenocarcinoma: MCM-family acts as a potential therapeutic target2021
- Author(s)
  Kengo Tanigawa, Keiko Mizuno, Shunsuke Misono, Minami Kawano, Takayuki Suetsugu, Hiromasa Inoue
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08656
[Presentation] microRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma2014
- Author(s)
  Hiroko Mataki, Naohiko Seki, Takeshi Chiyomaru, Hideki Enokida, Keiko Mizuno, Masayuki Nakagawa, Hiromasa Inoue
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24659407
[Presentation] 肺扁平上皮癌における腫瘍抑制性micro RNA-1/133aクラスタに関する検討
- Author(s)
  3)俣木浩子、水野圭子、井上博雅、他
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2015-04-17 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-24659407
[Presentation] MicroRNA-206 function as a tumor suppressor via targeting MET in lung squamous cell carcinoma.
- Author(s)
  俣木浩子、水野圭子、井上博雅、他
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24659407

1. Seki Naohiko (50345013)

# of Collaborated Projects: 10 results

# of Collaborated Products: 4 results
2. 末次隆行 (90862863)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. INOUE Hiromasa (30264039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. KUMAMOTO TOMOHIRO (20622517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Kamikawaji Kazuto (80633396)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Sanada Hiroki (10837777)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MATAKI Hiroko (60750750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Uchida Akifumi (40707923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 萩原陽子 (30992226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 五島悠介 (00710576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 武田亜矢 (80794700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 上村豪 (80927187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Keiko 水野 圭子

Mizuno Keiko 水野 圭子

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治療抵抗性獲得に関与する小細胞肺癌機能性RNA分子アトラスの構築Principal Investigator

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Devising drug repositioning based on functional RNA integration analysis of small cell lung cancer.Principal Investigator

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Elucidation of the involvement of the inflammatory response and development of a new marker and treatment in lung cancer growthPrincipal Investigator

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[Journal Article] Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target2021

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[Journal Article] Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma2021

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[Journal Article] The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes2017

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Journal Title

DOI

Data Source

[Journal Article] Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis.2016

Author(s)

MIZUNO Keiko 水野圭子

Mizuno Keiko 水野圭子