Hisamori Shigeo 久森重夫

Researcher Number	50534351
Other IDs	https://orcid.org/0000-0003-0163-6978
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 京都大学, 医学研究科, 講師 2016 – 2022: 京都大学, 医学研究科, 助教 2016: 京都大学, 医学研究科, 特定病院助教 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 胃癌 / マイクロRNA / 大腸癌 / 免疫チェックポイント阻害剤 / 抗PD-1抗体 / iRGD / セルライン / .胃癌 / 腹膜播種 / 癌 … More / 外科 / DCLK1 / 正常大腸幹細胞 / 大腸癌幹細胞 … More Except Principal Investigator 胃癌 / 大腸癌 / セラノスティクス / LDH阻害剤 / ワールバーグ効果 / 乳酸脱水素酵素 / がん代謝 / 代謝阻害療法 / 超偏極13CMRI / 代謝 / 膵癌 / OxPhos / 解糖系 / LDH阻害 / ピルビン酸代謝 / 超偏極13C-MRI / LDH阻害薬 / LDH / 癌代謝 / トラスツズマブ耐性 / HER2陽性胃癌 / 耐性 / Trastuzumab / BEZ235 / PTEN欠失 / トラスツズマブ / 食道腺癌 / HER2 / 転写因子ネットワーク / 薬剤排泄能 / 多様性形成 / 大腸癌幹細胞 / 転写因子 / iPS細胞技術 / 幹細胞生物学 / 人工癌幹細胞 / 癌幹細胞 Less

iRGDによる胃癌免疫チェックポイント阻害剤併用化学療法の選択的増強効果の可能性Principal Investigator
- Principal Investigator
  
  久森重夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Dynamic Imaging of LDH Inhibition in Tumors by 13C-MRI to Treat Colon Cancer
- Principal Investigator
  
  OSHIMA NOBU
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Elucidating the mechanism of peritoneal dissemination of gastric cancerPrincipal Investigator
- Principal Investigator
  
  Hisamori Shigeo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyoto University
Novel therapeutic strategy for Trastuzumab resistance in HER2-overexpressing gastroesophageal adenocarcinoma.
- Principal Investigator
  
  DEGUCHI YASUNORI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1Principal Investigator
- Principal Investigator
  
  Hisamori Shigeo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Application of induced colon cancer stem cells to elucidation of the molecular basis of cancer stem cell property in colon cancer stem cells
- Principal Investigator
  
  OSHIMA NOBU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022
- Author(s)
  Hisamori Shigeo、Mukohyama Junko、Koul Sanjay、Hayashi Takanori、Rothenberg Michael Evan、Maeda Masao、Isobe Taichi、Valencia Salazar Luis Enrique、Qian Xin、Johnston Darius Michael、Qian Dalong、Lao Kaiqin、Asai Naoya、Kakeji Yoshihiro、Gennarino Vincenzo Alessandro、Sahoo Debashis、Dalerba Piero、Shimono Yohei
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: Online ahead of print Issue: 6 Pages: 407-422
- DOI
  10.1007/s00535-022-01865-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09076, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-22K07010, KAKENHI-PROJECT-20K17687, KAKENHI-PROJECT-23K21387
[Journal Article] 超偏極13CMRIを用いた膵癌に対するLDH阻害治療効果の動的な可視化2020
- Author(s)
  大嶋野歩, 岸本俊, 石田諒, 愛須佑樹, 岡田倫明, 錦織達人, 板谷喜朗, 久森重夫, 角田茂, 肥田侯矢, 河田健二, 兵藤文紀, 松尾政之, 中本裕士, 小濱和貴, Neckers LM, Krishna MC, 坂井義治
- Journal Title
  
  胆と膵
  
  Volume: 41 Pages: 751-6
- Data Source
  KAKENHI-PROJECT-20K09054
[Journal Article] miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK12018
- Author(s)
  Sakaguchi M, Hisamori S, Oshima N, Sato F, Shimono Y, Sakai Y
- Journal Title
  
  Mol Cancer Res
  
  Volume: 14 Pages: 354-362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10539
[Journal Article] miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the inhibition of DCLK12017
- Author(s)
  M Sakaguchi, S Hisamori, N Oshima, F Sato, Y Shimono, Y Sakai
- Journal Title
  
  Molecular Cancerh Research
  
  Volume: 14 Pages: 354-362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10539
[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
- Organizer
  American College of Surgeons: Owen H Wangensteen Scientific Forum 2022, Excellence in reserach
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Shigeo Hisamori, Shigeru Tsunoda, Hiroki Hashida, Kenji Uryuhara, Hiroyuki Kobayashi, Masato Kondo, Koji Kitamura, Satoshi Kaihara, Kazutaka Obama, Krishna C. Murali, Len M. Neckers.
- Organizer
  The AACR Annual Meeting　2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 超偏極13C-MRIによる腫瘍組織内でのピルビン酸代謝の動的観察とセラノスティクスへの展開2022
- Author(s)
  大嶋野歩, 愛須佑樹, 久森重夫, 角田茂, 兵藤文紀, 松尾政之, 板谷喜朗, 橋田裕毅, 貝原聡, 小濱和貴
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022
- Author(s)
  Nobu Oshima, Yuki Aisu, Ryo Ishida, Shun kishimoto, Shigeo Hisamori, Shigeru Tsunoda, Satoshi Kaihara, Kazutaka Obama, Murali C. Krishna, Len Neckers
- Organizer
  American College of Surgeons, Clinical Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 消化器癌でのピルビン酸代謝モニタリングと治療応用2022
- Author(s)
  愛須佑樹, 大嶋野歩, 花田圭太, 岡田倫明, 板谷喜朗, 久森重夫, 角田茂, 河田健二, 兵藤文紀, 松尾政之, 小濱和貴
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 進行再発大腸癌に対する集学的アプローチの最先端超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021
- Author(s)
  大嶋野歩, 兵藤文紀, 松尾政之, 角田茂, 久森重夫, 板谷喜郎, 岡田倫明, 小林裕之, 橋田裕毅, 瓜生原健嗣, 近藤正人, 北村好史, 喜多亮介, 貝原聡, 小濱和貴
- Organizer
  第121回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 食道癌におけるこだわりの手術手技臓器鞘コンセプトに基づくロボット支援胸腔鏡下上縦隔リンパ節郭清2021
- Author(s)
  角田茂, 久森重夫, 錦織達人, 岡村亮輔, 前川久継, 大森敦仁, 板谷喜朗, 岡田倫明, 大嶋野歩, 肥田侯矢, 河田健二, 喜安佳之, 山本高正, 星野伸明, 村上克宏, 樽本浩司, 小濱和貴
- Organizer
  第121回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] Monitoring of pyruvate metabolism in tumors: application of 13C-MRSI to a novel treatment of targeting cancer metabolism2021
- Author(s)
  Nobu Oshima, Hiroki Hashida, Shigeo Hisamori, Shigeru Tsunoda, Kazutaka Obama2, Krishna MC, Neckers LM
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 超偏極13C-MRI用いた，薬剤による腫瘍組織内におけるピルビン酸代謝変容のモニタリング2021
- Author(s)
  大嶋野歩, 石田諒,　愛須佑樹, 久森重夫, 板谷喜郎, 兵藤文紀, 松尾政之, 角田茂, 貝原聡, 小濱和貴
- Organizer
  第76回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] 胃癌におけるピルビン酸代謝のモニタリングと代謝阻害療法の開発2021
- Author(s)
  愛須佑樹, 大嶋野歩, 花田圭太, 岡田倫明, 板谷喜朗, 久森重夫, 角田茂, 兵藤文紀, 松尾政之, 小濱和貴
- Organizer
  第76回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] MRIを用いた大腸癌におけるセラノスティクスー超偏極13C-MRIを用いた腫瘍内における代謝阻害剤効果のDynamic Monitoring～2020
- Author(s)
  大嶋野歩, 小濱和貴, 河田健二, 肥田候矢, 久森重夫, 出口靖記, 板谷喜郎, 水野礼, 和田聡朗, 錦織達人, 奥知慶久, 岡田倫明, 我如古理規, Krishna Murali, Neckers Leonard, 坂井義治
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-20K09054
[Presentation] PTEN欠失はHER2陽性胃・食道胃接合部癌におけるTrastuzumab治療抵抗性の予測因子である2019
- Author(s)
  横山大受、久森重夫、出口靖記、錦織達人、角田茂、小濱和貴、岡部寛、坂井義治
- Organizer
  第74回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-17K10585
[Presentation] PTEN欠失はHER2陽性胃・食道胃接合部腺癌におけるTrastuzumab治療抵抗性の予測因子である2019
- Author(s)
  横山大受、久森重夫、出口靖記、錦織達人、角田茂、小濱和貴、岡部寛、坂井義治
- Organizer
  第74回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10585
[Presentation] MicroRNA-137 regulates the tumorigenicity of colon cancer stem cells through the inhibition of DCLK12017
- Author(s)
  久森重夫、坂口正純　他
- Organizer
  第71回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10539
[Presentation] microRNA-137/DCLK1 axis: A novel mechanism regulating tumorigenicity of colon cancer stem cell2016
- Author(s)
  Masazumi Sakaguchi, Shigeo Hisamori, Nobu Oshima, Yoshiharu Sakai
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, LA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10139
[Presentation] 大腸癌幹細胞におけるmiR-137/DCLK1 axisの重要性2016
- Author(s)
  坂口正純、久森重夫、大嶋野歩、坂井義治
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K10139

1. OSHIMA NOBU (70571454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. AOI Takashi (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. DEGUCHI YASUNORI (50795581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 坂井義治 (60273455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 小濱和貴 (50322649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 兵藤文紀 (10380693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 板谷喜朗 (80814029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. Sakaguchi Masazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. Shimono Yohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Hisamori Shigeo 久森 重夫

Research Projects

Research Products

Co-Researchers

iRGDによる胃癌免疫チェックポイント阻害剤併用化学療法の選択的増強効果の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dynamic Imaging of LDH Inhibition in Tumors by 13C-MRI to Treat Colon Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the mechanism of peritoneal dissemination of gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic strategy for Trastuzumab resistance in HER2-overexpressing gastroesophageal adenocarcinoma.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of induced colon cancer stem cells to elucidation of the molecular basis of cancer stem cell property in colon cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 超偏極13CMRIを用いた膵癌に対するLDH阻害治療効果の動的な可視化2020

Author(s)

Journal Title

Data Source

[Journal Article] miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK12018

Author(s)

Journal Title

Data Source

[Journal Article] miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the inhibition of DCLK12017

Author(s)

Journal Title

Data Source

[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022

Author(s)

Organizer

Data Source

[Presentation] Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules2022

Author(s)

Organizer

Data Source

[Presentation] 超偏極13C-MRIによる腫瘍組織内でのピルビン酸代謝の動的観察とセラノスティクスへの展開2022

Author(s)

Organizer

Data Source

[Presentation] Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-time monitoring of pyruvate metabolic fluxes in vivo and targeting intra-tumor metabolic plasticity with small molecules2022

Author(s)

Organizer

Data Source

[Presentation] 消化器癌でのピルビン酸代謝モニタリングと治療応用2022

Author(s)

Organizer

Data Source

[Presentation] 進行再発大腸癌に対する集学的アプローチの最先端 超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021

Author(s)

Organizer

Hisamori Shigeo 久森重夫

[Presentation] 進行再発大腸癌に対する集学的アプローチの最先端超偏極13C-MRIによる、大腸癌腫瘍内における代謝反応の動的な可視化2021

[Presentation] 食道癌におけるこだわりの手術手技臓器鞘コンセプトに基づくロボット支援胸腔鏡下上縦隔リンパ節郭清2021

[Presentation] 超偏極13C-MRI用いた，薬剤による腫瘍組織内におけるピルビン酸代謝変容のモニタリング2021